STXBP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the STXBP/unc-18/SEC1 family. The encoded protein is involved in intracellular trafficking, control of SNARE (soluble NSF attachment protein receptor) complex assembly, and the release of cytotoxic granules by natural killer cells. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)4.82657088
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.67459081
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.65571191
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.65571191
5positive regulation of B cell differentiation (GO:0045579)4.45994795
6positive regulation of gamma-delta T cell activation (GO:0046645)4.44610425
7antigen processing and presentation of endogenous antigen (GO:0019883)4.43279347
8macrophage activation involved in immune response (GO:0002281)4.22050239
9viral transcription (GO:0019083)4.06779735
10* neutrophil activation involved in immune response (GO:0002283)4.05123723
11negative regulation of interleukin-12 production (GO:0032695)3.99851694
12regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.87626591
13translational termination (GO:0006415)3.81673152
14regulation of B cell differentiation (GO:0045577)3.77203222
15detection of external biotic stimulus (GO:0098581)3.76388430
16regulation of B cell receptor signaling pathway (GO:0050855)3.74475211
17respiratory burst (GO:0045730)3.73101095
18SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.71923684
19ribosomal small subunit biogenesis (GO:0042274)3.71060496
20cotranslational protein targeting to membrane (GO:0006613)3.68797844
21protein targeting to ER (GO:0045047)3.66482198
22immunoglobulin mediated immune response (GO:0016064)3.64745870
23* regulation of mast cell degranulation (GO:0043304)3.52411936
24antigen processing and presentation via MHC class Ib (GO:0002475)3.49955263
25protein localization to endoplasmic reticulum (GO:0070972)3.49211353
26positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.48677955
27negative regulation of myeloid cell apoptotic process (GO:0033033)3.48375557
28positive regulation of mast cell activation (GO:0033005)3.48346612
29establishment of protein localization to endoplasmic reticulum (GO:0072599)3.47772550
30B cell receptor signaling pathway (GO:0050853)3.43414078
31leukocyte aggregation (GO:0070486)3.42767487
32mast cell activation (GO:0045576)3.42761434
33negative regulation of lymphocyte mediated immunity (GO:0002707)3.42530520
34response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.39069553
35response to host immune response (GO:0052572)3.39069553
36erythrocyte maturation (GO:0043249)3.38773218
37* regulation of myeloid leukocyte mediated immunity (GO:0002886)3.30857707
38response to interferon-beta (GO:0035456)3.30620749
39detection of biotic stimulus (GO:0009595)3.30481129
40negative regulation of leukocyte mediated immunity (GO:0002704)3.22289402
41defense response to protozoan (GO:0042832)3.20978724
42* regulation of leukocyte degranulation (GO:0043300)3.20892005
43positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.20634131
44detection of molecule of bacterial origin (GO:0032490)3.20104127
45response to protozoan (GO:0001562)3.18724217
46regulation of gamma-delta T cell differentiation (GO:0045586)3.17931018
47viral life cycle (GO:0019058)3.17291935
48lipopolysaccharide-mediated signaling pathway (GO:0031663)3.17242665
49* regulation of mast cell activation involved in immune response (GO:0033006)3.17024657
50translational elongation (GO:0006414)3.16942783
51positive regulation of mast cell activation involved in immune response (GO:0033008)3.14335061
52positive regulation of mast cell degranulation (GO:0043306)3.14335061
53cellular hyperosmotic response (GO:0071474)3.14288922
54response to host (GO:0075136)3.12072697
55response to host defenses (GO:0052200)3.12072697
56response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.12072697
57response to peptidoglycan (GO:0032494)3.10087247
58cellular response to type I interferon (GO:0071357)3.10059568
59type I interferon signaling pathway (GO:0060337)3.10059568
60Arp2/3 complex-mediated actin nucleation (GO:0034314)3.07857375
61amyloid precursor protein catabolic process (GO:0042987)3.07669576
62response to type I interferon (GO:0034340)3.07412420
63macrophage activation (GO:0042116)3.06627413
64negative regulation of calcium ion transport into cytosol (GO:0010523)3.05749219
65regulation of gamma-delta T cell activation (GO:0046643)3.05695714
66regulation of dendritic cell antigen processing and presentation (GO:0002604)3.02368427
67microglial cell activation (GO:0001774)3.00391773
68B cell mediated immunity (GO:0019724)2.99607419
69negative regulation of T cell mediated immunity (GO:0002710)2.98556412
70positive regulation of antigen processing and presentation (GO:0002579)2.96557853
71positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.95529567
72positive thymic T cell selection (GO:0045059)2.94593805
73negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.94162635
74regulation of T cell tolerance induction (GO:0002664)2.92898985
75negative regulation of cytokine production involved in immune response (GO:0002719)2.91961267
76neutrophil mediated immunity (GO:0002446)2.91729231
77regulation of T-helper 2 cell differentiation (GO:0045628)2.88775108
78regulation of tolerance induction (GO:0002643)2.87377751
79cellular protein complex disassembly (GO:0043624)2.84994570
80positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.83368961
81cellular response to interferon-beta (GO:0035458)2.82248204
82mature B cell differentiation involved in immune response (GO:0002313)2.82110978
83response to interleukin-15 (GO:0070672)2.81759369
84negative regulation of phagocytosis (GO:0050765)2.79496102
85* neutrophil activation (GO:0042119)2.78841764
86nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.78781189
87negative regulation of innate immune response (GO:0045824)2.77961513
88negative regulation of erythrocyte differentiation (GO:0045647)2.76853948
89negative thymic T cell selection (GO:0045060)2.76158880
90regulation of antigen processing and presentation (GO:0002577)2.72978621
91regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.72554973
92mature B cell differentiation (GO:0002335)2.71359000
93* leukocyte degranulation (GO:0043299)2.71280820
94myeloid dendritic cell activation (GO:0001773)2.70406540
95regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.70121475
96positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.68815380
97positive regulation of cellular amide metabolic process (GO:0034250)2.68787583
98negative regulation of interleukin-6 production (GO:0032715)2.68477814
99* myeloid cell activation involved in immune response (GO:0002275)2.67101744
100regulation of alpha-beta T cell proliferation (GO:0046640)2.66264114
101hepatocyte apoptotic process (GO:0097284)2.66201567
102platelet dense granule organization (GO:0060155)2.66032952
103cellular extravasation (GO:0045123)2.65788159
104T cell selection (GO:0045058)2.64821690
105regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.64712006
106regulation of natural killer cell mediated immunity (GO:0002715)2.64712006
107positive regulation of type 2 immune response (GO:0002830)2.64602141
108modulation by symbiont of host defense response (GO:0052031)2.63945096
109modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.63945096
110modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.63945096
111positive regulation by organism of defense response of other organism involved in symbiotic interact2.63945096
112modulation by symbiont of host immune response (GO:0052553)2.63945096
113positive regulation by symbiont of host defense response (GO:0052509)2.63945096
114megakaryocyte development (GO:0035855)2.62694185
115regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.61234871
116regulation of interferon-beta biosynthetic process (GO:0045357)2.60864529
117signal peptide processing (GO:0006465)2.56488312
118T cell homeostasis (GO:0043029)2.55726493
119translational initiation (GO:0006413)2.54176485
120* granulocyte activation (GO:0036230)2.54100168
121negative regulation of cell killing (GO:0031342)2.54012674
122negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.54012674
123detection of other organism (GO:0098543)2.52451443
124NIK/NF-kappaB signaling (GO:0038061)2.51730364
125mast cell activation involved in immune response (GO:0002279)2.51529964
126mast cell degranulation (GO:0043303)2.51529964
127regulation of T cell receptor signaling pathway (GO:0050856)2.51476186
128interferon-gamma-mediated signaling pathway (GO:0060333)2.46943836
129response to muramyl dipeptide (GO:0032495)2.44654328
130maturation of SSU-rRNA (GO:0030490)2.43120195
131protein targeting to membrane (GO:0006612)2.42742163
132detection of bacterium (GO:0016045)2.42314606
133protein complex disassembly (GO:0043241)2.41315985
134germinal center formation (GO:0002467)2.38372272
135* regulation of mast cell activation (GO:0033003)2.37237135
136tolerance induction (GO:0002507)2.36941464
137production of molecular mediator involved in inflammatory response (GO:0002532)2.34277252
138angiogenesis involved in wound healing (GO:0060055)2.33851718
139leukocyte migration involved in inflammatory response (GO:0002523)2.33415867
140T cell migration (GO:0072678)2.33156472
141amyloid precursor protein metabolic process (GO:0042982)2.32746156
142definitive hemopoiesis (GO:0060216)2.32443960
143regulation of response to osmotic stress (GO:0047484)2.31691831
144leukotriene biosynthetic process (GO:0019370)2.31586444
145tumor necrosis factor-mediated signaling pathway (GO:0033209)2.31557823

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.40656019
2IRF8_21731497_ChIP-ChIP_J774_Mouse3.87215409
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.50200092
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.39080167
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.32308401
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.21678060
7SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.02068389
8SCL_19346495_ChIP-Seq_HPC-7_Human2.99642458
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.82221190
10RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.81586800
11SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.73226611
12E2F7_22180533_ChIP-Seq_HELA_Human2.61046611
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.60006413
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.52333356
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.47854007
16SPI1_23547873_ChIP-Seq_NB4_Human2.47236974
17VDR_21846776_ChIP-Seq_THP-1_Human2.45350361
18IRF8_27001747_Chip-Seq_BMDM_Mouse2.45013141
19NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.30413418
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.29809188
21* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.29732646
22STAT4_19710469_ChIP-ChIP_TH1__Mouse2.28701459
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.11613480
24TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.04915481
25GATA1_22025678_ChIP-Seq_K562_Human2.02954323
26RUNX1_22412390_ChIP-Seq_EML_Mouse2.00602952
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.97491023
28* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.97137054
29MYB_26560356_Chip-Seq_TH2_Human1.96937695
30MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.95664993
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.95273002
32LXR_22292898_ChIP-Seq_THP-1_Human1.93771602
33KDM2B_26808549_Chip-Seq_SUP-B15_Human1.93162387
34LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.87780278
35VDR_24763502_ChIP-Seq_THP-1_Human1.87763279
36MYC_22102868_ChIP-Seq_BL_Human1.87745905
37ELK3_25401928_ChIP-Seq_HUVEC_Human1.87394400
38MAF_26560356_Chip-Seq_TH1_Human1.85891902
39KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.85276549
40CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.84838544
41LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.82414035
42VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.81426498
43* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.81245000
44ERG_20887958_ChIP-Seq_HPC-7_Mouse1.79336894
45STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.77095439
46MYB_26560356_Chip-Seq_TH1_Human1.75917646
47KDM2B_26808549_Chip-Seq_DND41_Human1.71831718
48BRD4_27068464_Chip-Seq_AML-cells_Mouse1.71240395
49NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.66650637
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.64876603
51GATA1_19941826_ChIP-Seq_K562_Human1.63072800
52GATA1_22383799_ChIP-Seq_G1ME_Mouse1.62814632
53FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.60155743
54GABP_17652178_ChIP-ChIP_JURKAT_Human1.58143172
55UTX_26944678_Chip-Seq_JUKART_Human1.55759568
56GATA2_22383799_ChIP-Seq_G1ME_Mouse1.55178521
57EGR1_19374776_ChIP-ChIP_THP-1_Human1.51758580
58* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.51720751
59RUNX_20019798_ChIP-Seq_JUKART_Human1.50163928
60RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.49561610
61E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.47021998
62KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.43901333
63ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.43094899
64GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.43088112
65VDR_23849224_ChIP-Seq_CD4+_Human1.42670146
66EST1_17652178_ChIP-ChIP_JURKAT_Human1.42357180
67STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.41641970
68KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.38654377
69NCOR1_26117541_ChIP-Seq_K562_Human1.38647697
70BCL6_27268052_Chip-Seq_Bcells_Human1.37848548
71BCOR_27268052_Chip-Seq_Bcells_Human1.36699139
72JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.35986861
73STAT6_21828071_ChIP-Seq_BEAS2B_Human1.34996105
74MAF_26560356_Chip-Seq_TH2_Human1.33682761
75GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.30634321
76SPI1_23127762_ChIP-Seq_K562_Human1.29857444
77FOXP3_21729870_ChIP-Seq_TREG_Human1.29636183
78RACK7_27058665_Chip-Seq_MCF-7_Human1.27943310
79CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26199783
80CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23575504
81VDR_24787735_ChIP-Seq_THP-1_Human1.22740061
82ETS1_20019798_ChIP-Seq_JURKAT_Human1.22705778
83Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.22574589
84* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21906498
85CTCF_27219007_Chip-Seq_ERYTHROID_Human1.21816027
86MYC_18555785_ChIP-Seq_MESCs_Mouse1.21699269
87ELF1_20517297_ChIP-Seq_JURKAT_Human1.20606020
88PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20105735
89TCF7_22412390_ChIP-Seq_EML_Mouse1.18731470
90SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16115311
91MYC_18358816_ChIP-ChIP_MESCs_Mouse1.15150914
92TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.14903724
93* SRF_21415370_ChIP-Seq_HL-1_Mouse1.14732327
94P68_20966046_ChIP-Seq_HELA_Human1.14606376
95GATA2_19941826_ChIP-Seq_K562_Human1.13868979
96CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13094225
97NOTCH1_21737748_ChIP-Seq_TLL_Human1.12304810
98FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.11798911
99PU_27001747_Chip-Seq_BMDM_Mouse1.10838605
100GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10368704
101* GATA3_27048872_Chip-Seq_THYMUS_Human1.10177069
102* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09600110
103GATA1_19941827_ChIP-Seq_MEL_Mouse1.09172672
104PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07970993
105* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05642138
106SRY_22984422_ChIP-ChIP_TESTIS_Rat1.04807046
107PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04703593
108TFEB_21752829_ChIP-Seq_HELA_Human1.04566309
109KDM2B_26808549_Chip-Seq_JURKAT_Human1.04426896
110* SA1_27219007_Chip-Seq_ERYTHROID_Human1.04033669
111XRN2_22483619_ChIP-Seq_HELA_Human1.03749343
112CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.02626368
113IKZF1_21737484_ChIP-ChIP_HCT116_Human1.02347124
114PPARA_22158963_ChIP-Seq_LIVER_Mouse1.00446364
115RARG_19884340_ChIP-ChIP_MEFs_Mouse1.00290706
116CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.00081748
117ELK1_19687146_ChIP-ChIP_HELA_Human0.99625854
118CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99340594
119CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98936659
120TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98329253
121GATA2_21666600_ChIP-Seq_HMVEC_Human0.97070865
122SPI1_20517297_ChIP-Seq_HL60_Human0.95684072
123GATA3_26560356_Chip-Seq_TH2_Human0.95419635
124CIITA_25753668_ChIP-Seq_RAJI_Human0.94807869
125PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.92593621
126FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.92003451
127CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.91595141
128CREB1_15753290_ChIP-ChIP_HEK293T_Human0.90914676
129DCP1A_22483619_ChIP-Seq_HELA_Human0.89361873
130* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88467944
131ETS1_22383799_ChIP-Seq_G1ME_Mouse0.86947568
132E2F1_18555785_ChIP-Seq_MESCs_Mouse0.86057236
133TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85475214
134PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.85470407

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.08848078
2MP0009785_altered_susceptibility_to3.06687642
3MP0003436_decreased_susceptibility_to2.78770440
4MP0005671_abnormal_response_to2.78458669
5MP0005000_abnormal_immune_tolerance2.73450329
6MP0000685_abnormal_immune_system2.69251164
7MP0005025_abnormal_response_to2.69217156
8MP0002148_abnormal_hypersensitivity_rea2.68819533
9MP0005387_immune_system_phenotype2.63001713
10MP0001790_abnormal_immune_system2.63001713
11MP0001800_abnormal_humoral_immune2.59397538
12MP0002419_abnormal_innate_immunity2.52800333
13MP0002452_abnormal_antigen_presenting2.49429067
14MP0005464_abnormal_platelet_physiology2.48852909
15MP0002723_abnormal_immune_serum2.45860894
16MP0002420_abnormal_adaptive_immunity2.42910077
17MP0001819_abnormal_immune_cell2.40753190
18MP0005058_abnormal_lysosome_morphology2.36372789
19MP0002166_altered_tumor_susceptibility2.30865727
20MP0002396_abnormal_hematopoietic_system2.28676874
21MP0003724_increased_susceptibility_to2.15904160
22MP0005174_abnormal_tail_pigmentation2.10916123
23MP0002398_abnormal_bone_marrow2.08603447
24MP0001873_stomach_inflammation2.04583513
25MP0005310_abnormal_salivary_gland2.03941960
26MP0003763_abnormal_thymus_physiology2.03934119
27MP0006082_CNS_inflammation2.02911487
28MP0000716_abnormal_immune_system1.97858598
29MP0000465_gastrointestinal_hemorrhage1.96724727
30MP0002405_respiratory_system_inflammati1.90756053
31MP0010155_abnormal_intestine_physiology1.89169551
32MP0005075_abnormal_melanosome_morpholog1.87401025
33MP0003866_abnormal_defecation1.86435283
34MP0000689_abnormal_spleen_morphology1.85106940
35MP0003303_peritoneal_inflammation1.85072212
36MP0004947_skin_inflammation1.81068960
37MP0005451_abnormal_body_composition1.78978969
38MP0002722_abnormal_immune_system1.76668568
39MP0001845_abnormal_inflammatory_respons1.76434959
40MP0002006_tumorigenesis1.73005558
41MP0002429_abnormal_blood_cell1.71157646
42MP0003172_abnormal_lysosome_physiology1.62624467
43MP0009333_abnormal_splenocyte_physiolog1.62005898
44MP0001853_heart_inflammation1.50624787
45MP0008469_abnormal_protein_level1.46470832
46MP0000490_abnormal_crypts_of1.46275228
47MP0008004_abnormal_stomach_pH1.44087261
48MP0003828_pulmonary_edema1.42748701
49MP0003183_abnormal_peptide_metabolism1.42020997
50MP0003806_abnormal_nucleotide_metabolis1.41796863
51MP0003300_gastrointestinal_ulcer1.41731457
52MP0004510_myositis1.41237361
53MP0001545_abnormal_hematopoietic_system1.41221683
54MP0005397_hematopoietic_system_phenotyp1.41221683
55MP0003075_altered_response_to1.40539799
56MP0003191_abnormal_cellular_cholesterol1.37374584
57MP0002998_abnormal_bone_remodeling1.29292637
58MP0004381_abnormal_hair_follicle1.26208014
59MP0000703_abnormal_thymus_morphology1.22478216
60MP0001533_abnormal_skeleton_physiology1.21922903
61MP0004808_abnormal_hematopoietic_stem1.20125715
62MP0002095_abnormal_skin_pigmentation1.19582743
63MP0000858_altered_metastatic_potential1.19561001
64MP0003693_abnormal_embryo_hatching1.14737808
65MP0002933_joint_inflammation1.14435849
66MP0002138_abnormal_hepatobiliary_system1.11194651
67MP0000015_abnormal_ear_pigmentation1.11164317
68MP0005166_decreased_susceptibility_to1.10229688
69MP0001851_eye_inflammation1.09746849
70MP0008057_abnormal_DNA_replication1.08136322
71MP0001986_abnormal_taste_sensitivity1.08023289
72MP0002009_preneoplasia1.06123474
73MP0009840_abnormal_foam_cell1.05769183
74MP0004147_increased_porphyrin_level1.05608319
75MP0003186_abnormal_redox_activity1.03889567
76MP0001663_abnormal_digestive_system1.01589438
77MP0004264_abnormal_extraembryonic_tissu0.98845595
78MP0001348_abnormal_lacrimal_gland0.97017224
79MP0009764_decreased_sensitivity_to0.94742706
80MP0004883_abnormal_blood_vessel0.94247130
81MP0004782_abnormal_surfactant_physiolog0.92591702
82MP0002019_abnormal_tumor_incidence0.85536953
83MP0009643_abnormal_urine_homeostasis0.83963287
84MP0000604_amyloidosis0.83801300
85MP0005409_darkened_coat_color0.82845580
86MP0009278_abnormal_bone_marrow0.82424583
87MP0003656_abnormal_erythrocyte_physiolo0.82359493
88MP0002132_abnormal_respiratory_system0.81695820
89MP0002254_reproductive_system_inflammat0.81561679
90MP0010234_abnormal_vibrissa_follicle0.80193795
91MP0005164_abnormal_response_to0.80157580
92MP0000920_abnormal_myelination0.80014984
93MP0005390_skeleton_phenotype0.79829849
94MP0000343_altered_response_to0.79063341
95MP0003448_altered_tumor_morphology0.78615720
96MP0002277_abnormal_respiratory_mucosa0.75908628
97MP0009765_abnormal_xenobiotic_induced0.75798444
98MP0003453_abnormal_keratinocyte_physiol0.74462806
99MP0009763_increased_sensitivity_to0.73971335
100MP0006054_spinal_hemorrhage0.73367824
101MP0002136_abnormal_kidney_physiology0.73173275
102MP0005083_abnormal_biliary_tract0.72976926
103MP0003795_abnormal_bone_structure0.72024432
104MP0003690_abnormal_glial_cell0.72009224
105MP0002693_abnormal_pancreas_physiology0.70587244
106MP0000249_abnormal_blood_vessel0.70551637
107MP0000313_abnormal_cell_death0.69682430
108MP0005076_abnormal_cell_differentiation0.69207534
109MP0005381_digestive/alimentary_phenotyp0.68656259
110MP0005636_abnormal_mineral_homeostasis0.68380362
111MP0008874_decreased_physiological_sensi0.67817100
112MP0001666_abnormal_nutrient_absorption0.67741252
113MP0003566_abnormal_cell_adhesion0.65905640
114MP0000470_abnormal_stomach_morphology0.65846906
115MP0000609_abnormal_liver_physiology0.63865765
116MP0005319_abnormal_enzyme/_coenzyme0.63738325
117MP0000371_diluted_coat_color0.61399916
118MP0005408_hypopigmentation0.61323569
119MP0008260_abnormal_autophagy0.60124279
120MP0002139_abnormal_hepatobiliary_system0.58082861
121MP0001849_ear_inflammation0.57972430
122MP0003045_fibrosis0.56987350
123MP0009931_abnormal_skin_appearance0.52257334
124MP0003091_abnormal_cell_migration0.51569105

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.40594191
2Recurrent bacterial skin infections (HP:0005406)5.05741288
3Eczematoid dermatitis (HP:0000976)4.38865196
4Petechiae (HP:0000967)4.33504735
5Chronic otitis media (HP:0000389)4.31101553
6Vacuolated lymphocytes (HP:0001922)4.23873111
7Elevated erythrocyte sedimentation rate (HP:0003565)4.11825068
8IgM deficiency (HP:0002850)4.00858161
9* Abnormality of macrophages (HP:0004311)3.98894043
10Thrombocytosis (HP:0001894)3.54032295
11Recurrent viral infections (HP:0004429)3.49077245
12Recurrent fungal infections (HP:0002841)3.48460211
13Myositis (HP:0100614)3.45184365
14Recurrent skin infections (HP:0001581)3.44684189
15Gastrointestinal infarctions (HP:0005244)3.38015147
16Reticulocytopenia (HP:0001896)3.29526860
17Obstructive lung disease (HP:0006536)3.26498406
18Chronic obstructive pulmonary disease (HP:0006510)3.26498406
19Prolonged bleeding time (HP:0003010)3.22720659
20Abnormality of cells of the erythroid lineage (HP:0012130)3.22364043
21Abnormal number of erythroid precursors (HP:0012131)3.12770714
22Recurrent gram-negative bacterial infections (HP:0005420)3.07457309
23Meningitis (HP:0001287)3.04320907
24Increased neuronal autofluorescent lipopigment (HP:0002074)2.99515962
25Cellulitis (HP:0100658)2.97303379
26Aplastic anemia (HP:0001915)2.95578045
27Interstitial pulmonary disease (HP:0006530)2.89529616
28Panhypogammaglobulinemia (HP:0003139)2.88237865
29Vasculitis (HP:0002633)2.86635704
30Mediastinal lymphadenopathy (HP:0100721)2.84281967
31Increased cerebral lipofuscin (HP:0011813)2.81664823
32Keratoconjunctivitis sicca (HP:0001097)2.81436701
33Recurrent bronchitis (HP:0002837)2.78847573
34Abnormality of T cell physiology (HP:0011840)2.77912378
35Agammaglobulinemia (HP:0004432)2.76190466
36Epistaxis (HP:0000421)2.75223879
37Inflammation of the large intestine (HP:0002037)2.74587550
38Abnormal delayed hypersensitivity skin test (HP:0002963)2.72789822
39Pustule (HP:0200039)2.69689645
40Chest pain (HP:0100749)2.69460600
41Amyloidosis (HP:0011034)2.69063090
42Gastrointestinal inflammation (HP:0004386)2.69053866
43Systemic lupus erythematosus (HP:0002725)2.67112737
44Purpura (HP:0000979)2.66634252
45Pulmonary infiltrates (HP:0002113)2.61768230
46Increased IgM level (HP:0003496)2.59381848
47Abnormal platelet function (HP:0011869)2.57638971
48Impaired platelet aggregation (HP:0003540)2.57638971
49Keratoconjunctivitis (HP:0001096)2.54953023
50Orchitis (HP:0100796)2.54937038
51Abnormality of T cells (HP:0002843)2.54703848
52Gingivitis (HP:0000230)2.51341830
53Chronic mucocutaneous candidiasis (HP:0002728)2.48553099
54Recurrent cutaneous fungal infections (HP:0011370)2.48553099
55Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.48407485
56Retrobulbar optic neuritis (HP:0100654)2.46927422
57Optic neuritis (HP:0100653)2.46927422
58Hemoptysis (HP:0002105)2.46867061
59Gingival bleeding (HP:0000225)2.46195676
60Colitis (HP:0002583)2.45880930
61Arterial thrombosis (HP:0004420)2.44739147
62Recurrent pneumonia (HP:0006532)2.44485148
63B lymphocytopenia (HP:0010976)2.38745819
64Abnormality of B cell number (HP:0010975)2.38745819
65Pallor (HP:0000980)2.38196662
66Lymphopenia (HP:0001888)2.37617223
67Nasal polyposis (HP:0100582)2.36187018
68Hypochromic anemia (HP:0001931)2.35994692
69Dysostosis multiplex (HP:0000943)2.34107004
70Menorrhagia (HP:0000132)2.33533723
71Leukocytosis (HP:0001974)2.32939007
72Abnormality of cells of the lymphoid lineage (HP:0012140)2.32427624
73Granulocytopenia (HP:0001913)2.31955678
74Abnormality of the prostate (HP:0008775)2.31803360
75Anorexia (HP:0002039)2.31526881
76Autoimmune thrombocytopenia (HP:0001973)2.28730745
77Gastrointestinal stroma tumor (HP:0100723)2.28101259
78Abnormality of the heme biosynthetic pathway (HP:0010472)2.28068519
79Periodontitis (HP:0000704)2.23368954
80Osteomyelitis (HP:0002754)2.22985234
81Hypochromic microcytic anemia (HP:0004840)2.22942262
82Spontaneous hematomas (HP:0007420)2.20823027
83Encephalitis (HP:0002383)2.20562350
84Increased IgE level (HP:0003212)2.19833596
85Pulmonary embolism (HP:0002204)2.19545456
86Poikiloderma (HP:0001029)2.19288734
87Stomatitis (HP:0010280)2.18920650
88Abnormality of T cell number (HP:0011839)2.17692254
89Neutropenia (HP:0001875)2.17645469
90Urticaria (HP:0001025)2.17314405
91Loss of speech (HP:0002371)2.16608422
92Hypertensive crisis (HP:0100735)2.16487772
93T lymphocytopenia (HP:0005403)2.14649965
94Polycythemia (HP:0001901)2.12889445
95Agnosia (HP:0010524)2.12166620
96Abnormality of the nasal mucosa (HP:0000433)2.11639635
97Malnutrition (HP:0004395)2.11603296
98Eosinophilia (HP:0001880)2.11130653
99Recurrent sinusitis (HP:0011108)2.10346198
100Abnormality of eosinophils (HP:0001879)2.09637376
101IgG deficiency (HP:0004315)2.09337888
102Macrocytic anemia (HP:0001972)2.09162978
103Abnormality of liposaccharide metabolism (HP:0010968)2.08994374
104Abnormality of glycosphingolipid metabolism (HP:0004343)2.08994374
105Abnormality of glycolipid metabolism (HP:0010969)2.08994374
106* Increased serum ferritin (HP:0003281)2.08596498
107Sepsis (HP:0100806)2.04684106
108Cheilitis (HP:0100825)2.02996200
109Recurrent lower respiratory tract infections (HP:0002783)2.01597019
110Premature loss of primary teeth (HP:0006323)2.00811347
111Thyroiditis (HP:0100646)1.99587042
112Progressive neurologic deterioration (HP:0002344)1.99361237
113Gangrene (HP:0100758)1.99087886
114Abnormality of mucopolysaccharide metabolism (HP:0011020)1.98972969
115Abnormality of polysaccharide metabolism (HP:0011012)1.98972969
116Abnormality of glycosaminoglycan metabolism (HP:0004371)1.98972969
117Skin rash (HP:0000988)1.98337878
118Increased mean platelet volume (HP:0011877)1.98330588
119* Episodic fever (HP:0001954)1.98282853
120* Hepatosplenomegaly (HP:0001433)1.97991207
121Type I transferrin isoform profile (HP:0003642)1.95234477
122Abnormal platelet volume (HP:0011876)1.94918965
123Skin ulcer (HP:0200042)1.94583745
124Microcytic anemia (HP:0001935)1.93718511
125Hypergammaglobulinemia (HP:0010702)1.93604476
126Joint swelling (HP:0001386)1.93552390
127Hemorrhage of the eye (HP:0011885)1.93000872
128Lymphoma (HP:0002665)1.92986445
129Erythema (HP:0010783)1.92740755
130Glomerulopathy (HP:0100820)1.90822208
131Abnormality of the pleura (HP:0002103)1.90727120

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.04610401
2BLK3.09849414
3IRAK42.94516362
4KIT2.84609189
5TAOK32.80412565
6PRPF4B2.54129955
7TYK22.48123456
8MST42.47087474
9IRAK32.46908552
10BTK2.46234397
11TEC2.21801636
12TXK2.17867617
13MAP3K142.17528475
14ZAP702.12610179
15SYK1.93900525
16MAP3K111.93849411
17TBK11.93494517
18MAP3K31.90754824
19TAOK11.85747343
20JAK31.83716107
21IKBKE1.82730748
22PIM21.80597673
23RIPK41.78306201
24CSF1R1.77391981
25FLT31.76078553
26STK101.65973809
27STK161.60517118
28TRIB31.59794806
29EPHB11.57040205
30IKBKB1.56631223
31LRRK21.51244746
32TAOK21.51234920
33EEF2K1.51063924
34NME21.46949518
35LCK1.43082169
36ITK1.39979992
37CLK11.37855299
38ERN11.36066085
39SMG11.34063391
40RPS6KB21.33718484
41FES1.31983069
42MAP3K11.31363635
43GRK61.28747735
44TESK21.22338273
45SIK11.20188249
46LYN1.19018571
47HCK1.14837090
48CSK1.14536487
49MAP3K131.14155274
50CDK191.09171674
51BMPR21.02348214
52JAK11.00989088
53MATK0.96934186
54TGFBR10.95899694
55BMPR1B0.95552030
56TRPM70.91649010
57MAP2K30.90591788
58MAPK150.88741672
59BMX0.88633109
60PTK60.88542865
61KSR20.87576903
62PDPK10.87380959
63PIM10.87065269
64PDK10.86991841
65MARK20.84640015
66PRKD20.84158018
67MAP2K20.84064118
68TGFBR20.83368873
69CHUK0.82579154
70VRK10.82059753
71CDC42BPA0.78621152
72MAPKAPK50.78236364
73IRAK20.70315209
74IRAK10.70051807
75PASK0.69553868
76HIPK20.68116705
77TNK20.66481959
78MAP3K60.65827647
79PIK3CG0.65025320
80TNIK0.64614298
81CDK120.63571132
82PRKCQ0.62998017
83EIF2AK30.62465538
84DYRK30.62407981
85WEE10.61980148
86EPHA20.60629768
87MAP3K120.59264137
88MAPK120.58109274
89KDR0.57489370
90RPS6KA60.55605140
91RPS6KA40.55551744
92ICK0.53712978
93PRKCD0.53194761
94FYN0.53070263
95JAK20.52836571
96STK40.51629136
97MST1R0.49931036
98MAPKAPK20.47929388
99BCKDK0.47045871
100PAK40.46494907
101INSRR0.46374970
102ARAF0.45693436
103PKN20.44066299
104RPS6KC10.43794707
105RPS6KL10.43794707
106FGFR40.43504325
107TESK10.43330398
108MAP3K20.42579389
109PTK2B0.42424420
110MAPK70.41454423
111MAP3K50.41411547
112MAP3K80.40731762
113MAP2K60.40478524
114MAP3K70.39696156
115DYRK1B0.39309569
116RET0.38834404
117MAPKAPK30.38787967
118CDK70.37743673
119MARK30.37610532
120MAPK110.37313909
121OXSR10.37161035
122TSSK60.36982302
123CDK40.35639405
124GRK70.34874143
125RPS6KA50.34346394
126SIK30.34325698
127PRKG20.34134352
128STK240.33145047
129ACVR1B0.32788640
130ABL10.32203475
131RPS6KA20.31786930
132ADRBK20.31363138
133MAPK40.31147902
134YES10.31060601
135FGR0.30882685
136SIK20.30113386
137STK390.29469628
138RAF10.27041955
139FGFR30.24773270

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.55789113
2Primary immunodeficiency_Homo sapiens_hsa053403.07927295
3Hematopoietic cell lineage_Homo sapiens_hsa046402.63251367
4Leishmaniasis_Homo sapiens_hsa051402.43497815
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.39426073
6Other glycan degradation_Homo sapiens_hsa005112.33952803
7Protein export_Homo sapiens_hsa030602.30823519
8B cell receptor signaling pathway_Homo sapiens_hsa046622.07590860
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.01544354
10NF-kappa B signaling pathway_Homo sapiens_hsa040641.91941079
11Antigen processing and presentation_Homo sapiens_hsa046121.86795197
12Type I diabetes mellitus_Homo sapiens_hsa049401.84559888
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.83335596
14Measles_Homo sapiens_hsa051621.73877487
15DNA replication_Homo sapiens_hsa030301.73184203
16Osteoclast differentiation_Homo sapiens_hsa043801.70579367
17Glycosaminoglycan degradation_Homo sapiens_hsa005311.66741114
18Lysosome_Homo sapiens_hsa041421.63200325
19Folate biosynthesis_Homo sapiens_hsa007901.56339155
20Allograft rejection_Homo sapiens_hsa053301.56315808
21Viral myocarditis_Homo sapiens_hsa054161.54509249
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.52262438
23NOD-like receptor signaling pathway_Homo sapiens_hsa046211.50511163
24Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.49444991
25Jak-STAT signaling pathway_Homo sapiens_hsa046301.43216394
26Asthma_Homo sapiens_hsa053101.37936352
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.37333674
28Herpes simplex infection_Homo sapiens_hsa051681.36740278
29Rheumatoid arthritis_Homo sapiens_hsa053231.32301342
30Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.30207048
31Pertussis_Homo sapiens_hsa051331.29312312
32Graft-versus-host disease_Homo sapiens_hsa053321.27726258
33RNA polymerase_Homo sapiens_hsa030201.26882276
34Mismatch repair_Homo sapiens_hsa034301.24356985
35Legionellosis_Homo sapiens_hsa051341.24101249
36Tuberculosis_Homo sapiens_hsa051521.21321157
37Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.21282031
38Sulfur metabolism_Homo sapiens_hsa009201.20074068
39Shigellosis_Homo sapiens_hsa051311.18990512
40Base excision repair_Homo sapiens_hsa034101.18654058
41SNARE interactions in vesicular transport_Homo sapiens_hsa041301.13901168
42Staphylococcus aureus infection_Homo sapiens_hsa051501.13420822
43T cell receptor signaling pathway_Homo sapiens_hsa046601.12498592
44Proteasome_Homo sapiens_hsa030501.11669769
45Sulfur relay system_Homo sapiens_hsa041221.09689645
46Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.09626371
47Autoimmune thyroid disease_Homo sapiens_hsa053201.09590508
48African trypanosomiasis_Homo sapiens_hsa051431.09219776
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.07507026
50Influenza A_Homo sapiens_hsa051641.06796727
51Leukocyte transendothelial migration_Homo sapiens_hsa046701.06533848
52Homologous recombination_Homo sapiens_hsa034401.04492380
53Sphingolipid metabolism_Homo sapiens_hsa006001.01380855
54Non-homologous end-joining_Homo sapiens_hsa034501.00917004
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98257785
56Non-small cell lung cancer_Homo sapiens_hsa052230.98091051
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.96535385
58Pyrimidine metabolism_Homo sapiens_hsa002400.96324373
59Malaria_Homo sapiens_hsa051440.93383029
60Pancreatic cancer_Homo sapiens_hsa052120.91622913
61VEGF signaling pathway_Homo sapiens_hsa043700.90950452
62Apoptosis_Homo sapiens_hsa042100.90237948
63Chronic myeloid leukemia_Homo sapiens_hsa052200.89628380
64Toxoplasmosis_Homo sapiens_hsa051450.89409976
65Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.87350769
66Pentose phosphate pathway_Homo sapiens_hsa000300.85621191
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.84470431
68Acute myeloid leukemia_Homo sapiens_hsa052210.84315537
69Chemokine signaling pathway_Homo sapiens_hsa040620.82384031
70Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.80803877
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.80730171
72Salmonella infection_Homo sapiens_hsa051320.79938921
73Endocytosis_Homo sapiens_hsa041440.78455968
74Hepatitis B_Homo sapiens_hsa051610.77505354
75Fatty acid elongation_Homo sapiens_hsa000620.76451161
76Glutathione metabolism_Homo sapiens_hsa004800.75265636
77Epstein-Barr virus infection_Homo sapiens_hsa051690.74279695
78Maturity onset diabetes of the young_Homo sapiens_hsa049500.73868293
79Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.73334485
80Nucleotide excision repair_Homo sapiens_hsa034200.72474465
81Histidine metabolism_Homo sapiens_hsa003400.72183705
82Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.71926001
83Caffeine metabolism_Homo sapiens_hsa002320.71405915
84Arachidonic acid metabolism_Homo sapiens_hsa005900.70822002
85Hepatitis C_Homo sapiens_hsa051600.69819093
86Phagosome_Homo sapiens_hsa041450.68918834
87Steroid biosynthesis_Homo sapiens_hsa001000.66018370
88Spliceosome_Homo sapiens_hsa030400.65964491
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.65229485
90Platelet activation_Homo sapiens_hsa046110.64614476
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.64610712
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.62515367
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61055315
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60721846
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60695717
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60375756
97Renal cell carcinoma_Homo sapiens_hsa052110.60163867
98Notch signaling pathway_Homo sapiens_hsa043300.60022007
99Prolactin signaling pathway_Homo sapiens_hsa049170.59554663
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58640363
101AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58396340
102Neurotrophin signaling pathway_Homo sapiens_hsa047220.58359177
103Amoebiasis_Homo sapiens_hsa051460.57968767
104TNF signaling pathway_Homo sapiens_hsa046680.57763988
105Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56203160
106HTLV-I infection_Homo sapiens_hsa051660.55996408
107Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54092506
108ABC transporters_Homo sapiens_hsa020100.53788200
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.53443261
110Bladder cancer_Homo sapiens_hsa052190.52813049
111Regulation of autophagy_Homo sapiens_hsa041400.51968458
112Fanconi anemia pathway_Homo sapiens_hsa034600.51244486
113Phospholipase D signaling pathway_Homo sapiens_hsa040720.50707267
114Galactose metabolism_Homo sapiens_hsa000520.50591479
115Viral carcinogenesis_Homo sapiens_hsa052030.47697729
116HIF-1 signaling pathway_Homo sapiens_hsa040660.47665282
117Choline metabolism in cancer_Homo sapiens_hsa052310.47510519
118N-Glycan biosynthesis_Homo sapiens_hsa005100.47121977
119Ether lipid metabolism_Homo sapiens_hsa005650.46529629
120p53 signaling pathway_Homo sapiens_hsa041150.45731676
121Insulin resistance_Homo sapiens_hsa049310.43698877
122Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41931065
123Collecting duct acid secretion_Homo sapiens_hsa049660.40115049
124One carbon pool by folate_Homo sapiens_hsa006700.40114793
125Endometrial cancer_Homo sapiens_hsa052130.39127668
126Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37591800
127Renin-angiotensin system_Homo sapiens_hsa046140.36229149
128Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35829218
129Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35309502
130GnRH signaling pathway_Homo sapiens_hsa049120.35051304
131Vibrio cholerae infection_Homo sapiens_hsa051100.34639057
132Fructose and mannose metabolism_Homo sapiens_hsa000510.34376113
133mTOR signaling pathway_Homo sapiens_hsa041500.32997407
134FoxO signaling pathway_Homo sapiens_hsa040680.32149595
135Type II diabetes mellitus_Homo sapiens_hsa049300.30151929
136Complement and coagulation cascades_Homo sapiens_hsa046100.29689867
137Inositol phosphate metabolism_Homo sapiens_hsa005620.27675591
138Insulin signaling pathway_Homo sapiens_hsa049100.26223849

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