STX16-NPEPL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.22844984
2negative regulation of cell killing (GO:0031342)5.89768503
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.89768503
4positive regulation by symbiont of host defense response (GO:0052509)5.26207821
5modulation by symbiont of host defense response (GO:0052031)5.26207821
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.26207821
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.26207821
8positive regulation by organism of defense response of other organism involved in symbiotic interact5.26207821
9modulation by symbiont of host immune response (GO:0052553)5.26207821
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.81028759
11regulation of B cell receptor signaling pathway (GO:0050855)4.63994072
12regulation of gamma-delta T cell activation (GO:0046643)4.59574870
13leukocyte aggregation (GO:0070486)4.53111995
14negative thymic T cell selection (GO:0045060)4.47989054
15cellular extravasation (GO:0045123)4.46636638
16antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.43756874
17antigen processing and presentation of endogenous antigen (GO:0019883)4.43076690
18detection of other organism (GO:0098543)4.34512705
19negative T cell selection (GO:0043383)4.33129541
20positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.21293288
21response to muramyl dipeptide (GO:0032495)4.20511850
22macrophage activation involved in immune response (GO:0002281)4.16339651
23response to peptidoglycan (GO:0032494)4.15287428
24positive thymic T cell selection (GO:0045059)4.11678943
25response to interleukin-15 (GO:0070672)4.11170273
26detection of bacterium (GO:0016045)4.09343253
27negative regulation of lymphocyte mediated immunity (GO:0002707)4.08531287
28regulation of gamma-delta T cell differentiation (GO:0045586)4.06843349
29antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.01028545
30detection of molecule of bacterial origin (GO:0032490)3.88265686
31positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.87994875
32B cell receptor signaling pathway (GO:0050853)3.84907126
33germinal center formation (GO:0002467)3.82906218
34activated T cell proliferation (GO:0050798)3.82886838
35negative regulation of T cell mediated immunity (GO:0002710)3.79239646
36tolerance induction (GO:0002507)3.77467026
37positive T cell selection (GO:0043368)3.75776392
38detection of external biotic stimulus (GO:0098581)3.74721814
39negative regulation of interleukin-12 production (GO:0032695)3.70872568
40regulation of interferon-beta biosynthetic process (GO:0045357)3.69326821
41neutrophil mediated immunity (GO:0002446)3.67033513
42neutrophil activation involved in immune response (GO:0002283)3.66728084
43negative regulation of erythrocyte differentiation (GO:0045647)3.64332027
44T cell selection (GO:0045058)3.62196957
45thymic T cell selection (GO:0045061)3.60914001
46response to host immune response (GO:0052572)3.60184125
47response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.60184125
48negative regulation of leukocyte mediated immunity (GO:0002704)3.53335593
49leukocyte migration involved in inflammatory response (GO:0002523)3.45979766
50respiratory burst (GO:0045730)3.43457797
51histone H3-K36 demethylation (GO:0070544)3.39339852
52negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.38323039
53T cell migration (GO:0072678)3.36454775
54neutrophil activation (GO:0042119)3.35984829
55detection of biotic stimulus (GO:0009595)3.35821692
56response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.33750003
57response to host (GO:0075136)3.33750003
58response to host defenses (GO:0052200)3.33750003
59cellular response to interleukin-15 (GO:0071350)3.26404707
60positive regulation of B cell differentiation (GO:0045579)3.25644002
61regulation of B cell differentiation (GO:0045577)3.20645373
62microglial cell activation (GO:0001774)3.20156882
63interferon-gamma production (GO:0032609)3.19980585
64myeloid leukocyte mediated immunity (GO:0002444)3.19374161
65defense response to protozoan (GO:0042832)3.19244386
66positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.19050766
67macrophage activation (GO:0042116)3.15094465
68regulation of T cell tolerance induction (GO:0002664)3.12611059
69positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.09827200
70negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.08083897
71regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.07850961
72regulation of T-helper 2 cell differentiation (GO:0045628)3.07529851
73myeloid cell activation involved in immune response (GO:0002275)3.05054084
74positive regulation of granulocyte differentiation (GO:0030854)3.03932724
75regulation of mast cell degranulation (GO:0043304)3.02880203
76regulation of myeloid leukocyte mediated immunity (GO:0002886)3.02250671
77regulation of tolerance induction (GO:0002643)3.01330905
78granulocyte activation (GO:0036230)3.00066254
79negative regulation of innate immune response (GO:0045824)2.95536985
80negative regulation of cytokine production involved in immune response (GO:0002719)2.93091959
81regulation of mast cell activation involved in immune response (GO:0033006)2.91191490
82regulation of mast cell activation (GO:0033003)2.87099464
83immunoglobulin mediated immune response (GO:0016064)2.84354425
84response to protozoan (GO:0001562)2.82909846
85negative regulation of toll-like receptor signaling pathway (GO:0034122)2.82494620
86negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.82473687
87positive regulation of mast cell activation (GO:0033005)2.78190563
88production of molecular mediator involved in inflammatory response (GO:0002532)2.77822860
89regulation of ARF protein signal transduction (GO:0032012)2.77511701
90regulation of leukocyte degranulation (GO:0043300)2.76641382
91negative regulation of type 2 immune response (GO:0002829)2.76176269
92mannose metabolic process (GO:0006013)2.76101215
93negative regulation of B cell mediated immunity (GO:0002713)2.75144628
94negative regulation of immunoglobulin mediated immune response (GO:0002890)2.75144628
95type I interferon signaling pathway (GO:0060337)2.74515297
96cellular response to type I interferon (GO:0071357)2.74515297
97negative regulation of T-helper cell differentiation (GO:0045623)2.74321445
98negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.74321445
99response to type I interferon (GO:0034340)2.73633076
100negative regulation of interleukin-6 production (GO:0032715)2.72159926

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.38439092
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.29591506
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.47751244
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.43672990
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.32287473
6RUNX_20019798_ChIP-Seq_JUKART_Human3.04940996
7VDR_21846776_ChIP-Seq_THP-1_Human2.99252839
8MYC_22102868_ChIP-Seq_BL_Human2.97611201
9VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.95182846
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.91638208
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.83276882
12MAF_26560356_Chip-Seq_TH1_Human2.62104674
13TCF7_22412390_ChIP-Seq_EML_Mouse2.54999044
14KDM2B_26808549_Chip-Seq_SUP-B15_Human2.54504928
15FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.45863578
16E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.45792640
17VDR_24763502_ChIP-Seq_THP-1_Human2.44911510
18IRF8_27001747_Chip-Seq_BMDM_Mouse2.44889218
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.43626288
20UTX_26944678_Chip-Seq_JUKART_Human2.43241746
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.42409796
22KDM2B_26808549_Chip-Seq_DND41_Human2.34612499
23KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.29844452
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.27563350
25KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.26491192
26SPI1_23127762_ChIP-Seq_K562_Human2.22399622
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.18662734
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.15979577
29SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.15691084
30MYB_26560356_Chip-Seq_TH2_Human2.15554991
31MAF_26560356_Chip-Seq_TH2_Human2.12050332
32MYB_26560356_Chip-Seq_TH1_Human2.07129085
33* SPI1_23547873_ChIP-Seq_NB4_Human2.06885018
34RUNX1_22412390_ChIP-Seq_EML_Mouse2.05756646
35IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.03678751
36SCL_19346495_ChIP-Seq_HPC-7_Human2.01069387
37EGR1_19374776_ChIP-ChIP_THP-1_Human1.95612635
38MYB_21317192_ChIP-Seq_ERMYB_Mouse1.94543632
39RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.93961380
40BRD4_27068464_Chip-Seq_AML-cells_Mouse1.91206208
41IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.90675447
42STAT4_19710469_ChIP-ChIP_TH1__Mouse1.79949275
43NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.77341104
44KDM2B_26808549_Chip-Seq_JURKAT_Human1.76354597
45GATA1_19941827_ChIP-Seq_MEL_Mouse1.75081016
46MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.67362281
47GATA3_27048872_Chip-Seq_THYMUS_Human1.66490381
48TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58448877
49GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.55776018
50VDR_24787735_ChIP-Seq_THP-1_Human1.55098682
51EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53677824
52TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.51875781
53LXR_22292898_ChIP-Seq_THP-1_Human1.51179304
54CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.50202565
55ELK3_25401928_ChIP-Seq_HUVEC_Human1.35747860
56CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34294141
57KDM2B_26808549_Chip-Seq_K562_Human1.29434845
58ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.28563542
59Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.25614199
60DROSHA_22980978_ChIP-Seq_HELA_Human1.25392272
61PU.1_20513432_ChIP-Seq_Bcells_Mouse1.25014578
62PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24201632
63CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23670341
64IKZF1_21737484_ChIP-ChIP_HCT116_Human1.22675691
65PU_27001747_Chip-Seq_BMDM_Mouse1.22605564
66LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.20411068
67CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19544564
68PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18376518
69PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16922260
70CIITA_25753668_ChIP-Seq_RAJI_Human1.16756296
71STAT6_21828071_ChIP-Seq_BEAS2B_Human1.15874741
72CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14992043
73RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.14353223
74GATA2_22383799_ChIP-Seq_G1ME_Mouse1.13227666
75CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08864462
76SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06945020
77GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06208760
78GATA3_26560356_Chip-Seq_TH2_Human1.05518388
79EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04322894
80RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01923193
81FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01268782
82GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01241644
83SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00357341
84DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99304595
85SA1_27219007_Chip-Seq_ERYTHROID_Human0.98607195
86BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.98004278
87ZFP281_27345836_Chip-Seq_ESCs_Mouse0.96804492
88BCOR_27268052_Chip-Seq_Bcells_Human0.96738647
89VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.96194210
90LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.95907867
91SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.95305350
92SMC4_20622854_ChIP-Seq_HELA_Human0.94872849
93GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.94630164
94GATA1_19941826_ChIP-Seq_K562_Human0.94499772
95SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.94038842
96ZFP281_18757296_ChIP-ChIP_E14_Mouse0.93716739
97SMAD_19615063_ChIP-ChIP_OVARY_Human0.93632694
98BCL6_27268052_Chip-Seq_Bcells_Human0.93281190
99NCOR1_26117541_ChIP-Seq_K562_Human0.92618826
100RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.91328896

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to4.30413831
2MP0003724_increased_susceptibility_to4.07358266
3MP0003303_peritoneal_inflammation3.68024806
4MP0001835_abnormal_antigen_presentation3.16521932
5MP0001800_abnormal_humoral_immune2.97585222
6MP0003172_abnormal_lysosome_physiology2.89738512
7MP0005451_abnormal_body_composition2.79663315
8MP0002419_abnormal_innate_immunity2.78997494
9MP0003763_abnormal_thymus_physiology2.77856592
10MP0000685_abnormal_immune_system2.70691304
11MP0005671_abnormal_response_to2.66821788
12MP0005000_abnormal_immune_tolerance2.64220065
13MP0008260_abnormal_autophagy2.61056409
14MP0001790_abnormal_immune_system2.60135615
15MP0005387_immune_system_phenotype2.60135615
16MP0005025_abnormal_response_to2.59827345
17MP0002723_abnormal_immune_serum2.50433709
18MP0002420_abnormal_adaptive_immunity2.42783074
19MP0001819_abnormal_immune_cell2.39653230
20MP0002452_abnormal_antigen_presenting2.31559472
21MP0003300_gastrointestinal_ulcer2.22918720
22MP0009278_abnormal_bone_marrow2.11833068
23MP0009785_altered_susceptibility_to2.01351405
24MP0002405_respiratory_system_inflammati1.98876073
25MP0002398_abnormal_bone_marrow1.97876980
26MP0003191_abnormal_cellular_cholesterol1.94766831
27MP0002132_abnormal_respiratory_system1.92925207
28MP0000716_abnormal_immune_system1.91930975
29MP0002396_abnormal_hematopoietic_system1.82703538
30MP0006082_CNS_inflammation1.79473808
31MP0001533_abnormal_skeleton_physiology1.77643021
32MP0005464_abnormal_platelet_physiology1.75986066
33MP0004510_myositis1.72602616
34MP0004947_skin_inflammation1.68125153
35MP0000703_abnormal_thymus_morphology1.67154842
36MP0000689_abnormal_spleen_morphology1.63511437
37MP0002722_abnormal_immune_system1.63265576
38MP0003122_maternal_imprinting1.63055216
39MP0004381_abnormal_hair_follicle1.62758608
40MP0009333_abnormal_splenocyte_physiolog1.60082431
41MP0003866_abnormal_defecation1.55003387
42MP0003828_pulmonary_edema1.50045406
43MP0002429_abnormal_blood_cell1.45193701
44MP0001845_abnormal_inflammatory_respons1.41892623
45MP0002009_preneoplasia1.40886865
46MP0003690_abnormal_glial_cell1.40839470
47MP0010155_abnormal_intestine_physiology1.40383730
48MP0002148_abnormal_hypersensitivity_rea1.33671736
49MP0001986_abnormal_taste_sensitivity1.32796386
50MP0004883_abnormal_blood_vessel1.32186143
51MP0000465_gastrointestinal_hemorrhage1.31992258
52MP0002277_abnormal_respiratory_mucosa1.26038186
53MP0001851_eye_inflammation1.23267548
54MP0008469_abnormal_protein_level1.22922436
55MP0005310_abnormal_salivary_gland1.22057772
56MP0001545_abnormal_hematopoietic_system1.20645357
57MP0005397_hematopoietic_system_phenotyp1.20645357
58MP0003221_abnormal_cardiomyocyte_apopto1.18524355
59MP0002933_joint_inflammation1.10906890
60MP0004130_abnormal_muscle_cell1.07803950
61MP0002166_altered_tumor_susceptibility1.06862220
62MP0005058_abnormal_lysosome_morphology1.06038511
63MP0001873_stomach_inflammation1.05807117
64MP0000858_altered_metastatic_potential1.05668287
65MP0002998_abnormal_bone_remodeling1.04848743
66MP0003787_abnormal_imprinting1.03771061
67MP0005076_abnormal_cell_differentiation0.99560380
68MP0002822_catalepsy0.94371226
69MP0003183_abnormal_peptide_metabolism0.93234368
70MP0000604_amyloidosis0.89475865
71MP0009764_decreased_sensitivity_to0.84320406
72MP0008961_abnormal_basal_metabolism0.82339987
73MP0004808_abnormal_hematopoietic_stem0.77259464
74MP0003656_abnormal_erythrocyte_physiolo0.76056508
75MP0001853_heart_inflammation0.74861444
76MP0003075_altered_response_to0.72888751
77MP0001663_abnormal_digestive_system0.72294463
78MP0005164_abnormal_response_to0.71162306
79MP0002928_abnormal_bile_duct0.68143918
80MP0008569_lethality_at_weaning0.64695977
81MP0009763_increased_sensitivity_to0.61608295
82MP0003329_amyloid_beta_deposits0.61551940
83MP0005075_abnormal_melanosome_morpholog0.61525179
84MP0009840_abnormal_foam_cell0.60829342
85MP0002006_tumorigenesis0.58287273
86MP0000249_abnormal_blood_vessel0.57627654
87MP0005167_abnormal_blood-brain_barrier0.57289708
88MP0003121_genomic_imprinting0.55925538
89MP0000609_abnormal_liver_physiology0.54626559
90MP0003091_abnormal_cell_migration0.53830517
91MP0001348_abnormal_lacrimal_gland0.53798879
92MP0002693_abnormal_pancreas_physiology0.52253509
93MP0008874_decreased_physiological_sensi0.51999936
94MP0000920_abnormal_myelination0.51980023
95MP0009115_abnormal_fat_cell0.51062307
96MP0003045_fibrosis0.48596734
97MP0005377_hearing/vestibular/ear_phenot0.48517089
98MP0003878_abnormal_ear_physiology0.48517089
99MP0002332_abnormal_exercise_endurance0.48345718
100MP0005360_urolithiasis0.47787115

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.19659678
2Recurrent bacterial skin infections (HP:0005406)5.28629894
3Myositis (HP:0100614)5.12650079
4Recurrent abscess formation (HP:0002722)5.02038955
5Optic neuritis (HP:0100653)4.87586264
6Retrobulbar optic neuritis (HP:0100654)4.87586264
7Orchitis (HP:0100796)4.77657275
8Abnormality of macrophages (HP:0004311)4.45101368
9Recurrent gram-negative bacterial infections (HP:0005420)4.39028109
10Recurrent fungal infections (HP:0002841)4.18537906
11Stomatitis (HP:0010280)4.14617278
12Abnormal delayed hypersensitivity skin test (HP:0002963)4.10481875
13Gastrointestinal infarctions (HP:0005244)4.07666043
14Mediastinal lymphadenopathy (HP:0100721)3.85381658
15Meningitis (HP:0001287)3.81600865
16Recurrent skin infections (HP:0001581)3.71850292
17Elevated erythrocyte sedimentation rate (HP:0003565)3.70711728
18Recurrent cutaneous fungal infections (HP:0011370)3.59481376
19Chronic mucocutaneous candidiasis (HP:0002728)3.59481376
20Encephalitis (HP:0002383)3.58464282
21Pustule (HP:0200039)3.55698355
22Panhypogammaglobulinemia (HP:0003139)3.52409475
23Increased IgE level (HP:0003212)3.46966358
24Vasculitis (HP:0002633)3.35445378
25Obstructive lung disease (HP:0006536)3.31999444
26Chronic obstructive pulmonary disease (HP:0006510)3.31999444
27Keratoconjunctivitis sicca (HP:0001097)3.29494263
28Prolonged bleeding time (HP:0003010)3.22888366
29Colitis (HP:0002583)3.15047237
30Inflammation of the large intestine (HP:0002037)3.07567943
31Gastrointestinal inflammation (HP:0004386)3.05074474
32Spontaneous hematomas (HP:0007420)3.01969694
33Keratoconjunctivitis (HP:0001096)2.96508342
34Gingival bleeding (HP:0000225)2.93038402
35Gingivitis (HP:0000230)2.91485507
36Deep venous thrombosis (HP:0002625)2.86500387
37Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.85196831
38Chest pain (HP:0100749)2.85157015
39Recurrent viral infections (HP:0004429)2.78570833
40Episodic fever (HP:0001954)2.77063409
41T lymphocytopenia (HP:0005403)2.76158887
42Pulmonary embolism (HP:0002204)2.69124689
43Hemoptysis (HP:0002105)2.67500965
44Cellulitis (HP:0100658)2.65177588
45Pulmonary infiltrates (HP:0002113)2.63972820
46Epistaxis (HP:0000421)2.62346300
47Viral hepatitis (HP:0006562)2.61822148
48Abnormality of T cell number (HP:0011839)2.57867124
49Arterial thrombosis (HP:0004420)2.56043133
50Abnormality of T cells (HP:0002843)2.51311305
51Urticaria (HP:0001025)2.51214812
52Leukocytosis (HP:0001974)2.44786439
53Hypochromic anemia (HP:0001931)2.44510646
54Granulocytopenia (HP:0001913)2.44190300
55Papilledema (HP:0001085)2.42609049
56Abnormality of the fingertips (HP:0001211)2.41797506
57Agammaglobulinemia (HP:0004432)2.32724396
58Increased IgM level (HP:0003496)2.31705451
59Joint hemorrhage (HP:0005261)2.29768143
60Slow saccadic eye movements (HP:0000514)2.25788003
61Anorexia (HP:0002039)2.24942528
62Amyloidosis (HP:0011034)2.23887516
63Abnormality of the endocardium (HP:0004306)2.20497788
64Abnormality of T cell physiology (HP:0011840)2.18670234
65Subacute progressive viral hepatitis (HP:0006572)2.18580572
66Peritonitis (HP:0002586)2.16503811
67Gangrene (HP:0100758)2.16320376
68Lymphopenia (HP:0001888)2.14424868
69Abnormality of the pleura (HP:0002103)2.11745776
70Joint swelling (HP:0001386)2.09797488
71Abnormality of the peritoneum (HP:0002585)2.07612569
72IgM deficiency (HP:0002850)2.05643532
73Sepsis (HP:0100806)1.99615951
74Verrucae (HP:0200043)1.96473461
75Papilloma (HP:0012740)1.96473461
76Acute hepatic failure (HP:0006554)1.93865362
77Hemorrhage of the eye (HP:0011885)1.93275434
78Abnormality of cells of the lymphoid lineage (HP:0012140)1.92888405
79Glomerulopathy (HP:0100820)1.92323212
80Peripheral hypomyelination (HP:0007182)1.92222180
81Eosinophilia (HP:0001880)1.90860423
82Keratitis (HP:0000491)1.90192981
83Recurrent sinusitis (HP:0011108)1.89946547
84Osteomyelitis (HP:0002754)1.87748361
85Supernumerary ribs (HP:0005815)1.85335773
86Hypochromic microcytic anemia (HP:0004840)1.83930737
87Neuronal loss in central nervous system (HP:0002529)1.82451859
88Vertigo (HP:0002321)1.82425280
89Metaphyseal cupping (HP:0003021)1.82422361
90Difficulty running (HP:0009046)1.80091868
91Menorrhagia (HP:0000132)1.77886585
92Segmental peripheral demyelination/remyelination (HP:0003481)1.77537053
93Acne (HP:0001061)1.77412743
94Fatigue (HP:0012378)1.76568962
95Dislocated radial head (HP:0003083)1.76420313
96Thrombophlebitis (HP:0004418)1.76105798
97Basal cell carcinoma (HP:0002671)1.75356599
98Cheilitis (HP:0100825)1.75327285
99Abnormality of the radial head (HP:0003995)1.75236660
100Gastrointestinal stroma tumor (HP:0100723)1.74549345

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.71127114
2RIPK43.37004515
3PRPF4B3.12531274
4SIK22.99709486
5IRAK42.55351145
6TYK22.41983573
7BLK2.39344462
8MAP2K32.17308544
9FGFR42.13241319
10FES2.00100310
11SIK31.99451909
12TNK21.98087808
13CSK1.81387961
14GRK61.79465618
15TRIB31.74870233
16ZAP701.71728194
17TAOK31.62945255
18BTK1.61239153
19TXK1.61193279
20ERN11.58937034
21MARK21.57979126
22FGFR31.54904643
23IKBKE1.54701102
24MAP3K141.49362433
25EPHB11.46878884
26MAP3K131.46714993
27HCK1.44110722
28FGR1.43961238
29SYK1.39296071
30CDK121.39227325
31TAOK11.36468941
32KSR21.30606256
33ITK1.30193796
34JAK31.28002543
35PKN21.23749149
36MAP3K111.21007893
37JAK21.17151858
38TBK11.17150868
39JAK11.16200978
40SIK11.15905285
41MAP3K71.14871341
42DYRK1B1.06389400
43LCK1.05547803
44IRAK21.04576014
45ICK1.04143688
46CSF1R1.02562817
47MAP3K11.02454242
48MAP3K101.00737522
49LYN0.99313039
50RET0.99224323
51TYRO30.97232752
52MAPK120.96786968
53MARK30.91741128
54PDK10.91608419
55MAP2K40.91557681
56PASK0.86376351
57PRKD20.86009609
58MAP3K60.85295500
59CDC42BPA0.84625077
60CAMKK10.82312700
61IRAK10.81394674
62MAP3K30.79755176
63SGK30.77479340
64PTK60.77424381
65MAPK70.75800923
66SGK20.74307996
67IKBKB0.70630546
68PDPK10.69440754
69CAMK40.68879706
70YES10.65954629
71MATK0.65937202
72EPHA30.64278339
73MAP3K20.62299739
74BRD40.62104469
75CDK190.58587847
76FYN0.57804464
77SGK4940.57563512
78SGK2230.57563512
79HIPK20.56470606
80TEC0.56385548
81STK110.55254927
82NLK0.54313394
83FGFR20.53254581
84WNK10.48844895
85RPS6KC10.48185084
86RPS6KL10.48185084
87KIT0.48078692
88UHMK10.47927075
89KSR10.47797049
90NTRK20.46805474
91CHUK0.46461428
92MAPK110.45744221
93SMG10.43244969
94STK380.42232220
95RPS6KA60.41999562
96DYRK30.41188946
97PRKCQ0.40278586
98PRKCH0.40278032
99MAP3K50.40036188
100CDK40.39305446

Predicted pathways (KEGG)

RankGene SetZ-score
1Osteoclast differentiation_Homo sapiens_hsa043802.68638130
2Leishmaniasis_Homo sapiens_hsa051402.44426251
3B cell receptor signaling pathway_Homo sapiens_hsa046622.39960731
4Staphylococcus aureus infection_Homo sapiens_hsa051502.16224595
5Primary immunodeficiency_Homo sapiens_hsa053402.15466417
6Fc epsilon RI signaling pathway_Homo sapiens_hsa046642.04691617
7Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.01512969
8T cell receptor signaling pathway_Homo sapiens_hsa046601.99234476
9Acute myeloid leukemia_Homo sapiens_hsa052211.98823616
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.95595450
11Toll-like receptor signaling pathway_Homo sapiens_hsa046201.84972305
12Other glycan degradation_Homo sapiens_hsa005111.76963609
13NOD-like receptor signaling pathway_Homo sapiens_hsa046211.76601472
14Tuberculosis_Homo sapiens_hsa051521.72084588
15Non-small cell lung cancer_Homo sapiens_hsa052231.67539745
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.59968429
17Measles_Homo sapiens_hsa051621.58545687
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.56193574
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.53189997
20Graft-versus-host disease_Homo sapiens_hsa053321.52338439
21Chemokine signaling pathway_Homo sapiens_hsa040621.48980794
22Allograft rejection_Homo sapiens_hsa053301.39161501
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.34374129
24Toxoplasmosis_Homo sapiens_hsa051451.34183804
25Influenza A_Homo sapiens_hsa051641.33907361
26Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.32874466
27Hepatitis B_Homo sapiens_hsa051611.31495409
28Autoimmune thyroid disease_Homo sapiens_hsa053201.31151853
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.29701698
30VEGF signaling pathway_Homo sapiens_hsa043701.28601262
31TNF signaling pathway_Homo sapiens_hsa046681.27048799
32Phosphatidylinositol signaling system_Homo sapiens_hsa040701.22293757
33Neurotrophin signaling pathway_Homo sapiens_hsa047221.19283593
34Endometrial cancer_Homo sapiens_hsa052131.18400916
35Prolactin signaling pathway_Homo sapiens_hsa049171.18241388
36Chronic myeloid leukemia_Homo sapiens_hsa052201.17942383
37Legionellosis_Homo sapiens_hsa051341.15537058
38Herpes simplex infection_Homo sapiens_hsa051681.14330249
39Hematopoietic cell lineage_Homo sapiens_hsa046401.13785752
40Choline metabolism in cancer_Homo sapiens_hsa052311.13124789
41Pancreatic cancer_Homo sapiens_hsa052121.11265379
42Renal cell carcinoma_Homo sapiens_hsa052111.09780462
43Malaria_Homo sapiens_hsa051441.05804672
44Hepatitis C_Homo sapiens_hsa051601.05364549
45Type I diabetes mellitus_Homo sapiens_hsa049401.04415546
46mTOR signaling pathway_Homo sapiens_hsa041501.04391126
47Platelet activation_Homo sapiens_hsa046111.03166122
48Inositol phosphate metabolism_Homo sapiens_hsa005621.02173922
49GnRH signaling pathway_Homo sapiens_hsa049121.01808171
50Leukocyte transendothelial migration_Homo sapiens_hsa046701.00668107
51Notch signaling pathway_Homo sapiens_hsa043300.99857192
52Type II diabetes mellitus_Homo sapiens_hsa049300.99792699
53Phospholipase D signaling pathway_Homo sapiens_hsa040720.97622688
54Colorectal cancer_Homo sapiens_hsa052100.95933893
55FoxO signaling pathway_Homo sapiens_hsa040680.95755435
56Carbohydrate digestion and absorption_Homo sapiens_hsa049730.95376115
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.95137194
58Viral myocarditis_Homo sapiens_hsa054160.93838266
59Pertussis_Homo sapiens_hsa051330.93809431
60Intestinal immune network for IgA production_Homo sapiens_hsa046720.91925230
61Antigen processing and presentation_Homo sapiens_hsa046120.90981263
62African trypanosomiasis_Homo sapiens_hsa051430.86278024
63ErbB signaling pathway_Homo sapiens_hsa040120.86206719
64Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84007101
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80954685
66MAPK signaling pathway_Homo sapiens_hsa040100.79234193
67Insulin resistance_Homo sapiens_hsa049310.77889527
68HIF-1 signaling pathway_Homo sapiens_hsa040660.77251620
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.77177734
70Apoptosis_Homo sapiens_hsa042100.77046325
71Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.75354515
72Long-term potentiation_Homo sapiens_hsa047200.75139384
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.74795748
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73833551
75Viral carcinogenesis_Homo sapiens_hsa052030.70658981
76Phagosome_Homo sapiens_hsa041450.70066372
77Endocytosis_Homo sapiens_hsa041440.68983519
78Epstein-Barr virus infection_Homo sapiens_hsa051690.68230779
79Dorso-ventral axis formation_Homo sapiens_hsa043200.67897465
80Insulin signaling pathway_Homo sapiens_hsa049100.67742032
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64481559
82Glioma_Homo sapiens_hsa052140.63755020
83Regulation of autophagy_Homo sapiens_hsa041400.62160886
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61640875
85Salmonella infection_Homo sapiens_hsa051320.60826408
86Estrogen signaling pathway_Homo sapiens_hsa049150.60629164
87Shigellosis_Homo sapiens_hsa051310.60445461
88Prostate cancer_Homo sapiens_hsa052150.58182144
89Complement and coagulation cascades_Homo sapiens_hsa046100.57518671
90Cholinergic synapse_Homo sapiens_hsa047250.54722577
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53473725
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.53115541
93HTLV-I infection_Homo sapiens_hsa051660.52369705
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50708862
95Rap1 signaling pathway_Homo sapiens_hsa040150.49244317
96Glycosaminoglycan degradation_Homo sapiens_hsa005310.47630112
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47120882
98Ras signaling pathway_Homo sapiens_hsa040140.45886679
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45656096
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41045758

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