STRIP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vitamin A metabolic process (GO:0006776)8.81248249
2diterpenoid biosynthetic process (GO:0016102)7.72877514
3terpenoid biosynthetic process (GO:0016114)6.18270339
4righting reflex (GO:0060013)5.47355450
5regulation of lipoprotein metabolic process (GO:0050746)5.27048678
6muscle filament sliding (GO:0030049)5.23737563
7actin-myosin filament sliding (GO:0033275)5.23737563
8regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)5.18055418
9ketone body metabolic process (GO:1902224)4.85289942
10membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.82866736
11regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.64456827
12sarcoplasmic reticulum calcium ion transport (GO:0070296)4.64311905
13positive regulation of osteoblast proliferation (GO:0033690)4.63312071
14retinal metabolic process (GO:0042574)4.61764276
15negative regulation of cytosolic calcium ion concentration (GO:0051481)4.59711354
16cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.57581267
17regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.37463820
18regulation of synapse structural plasticity (GO:0051823)4.34189079
19negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.34113397
20regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.26631034
21positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.21085094
22regulation of membrane repolarization (GO:0060306)4.19491543
23actin-mediated cell contraction (GO:0070252)4.17862694
24regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.17620068
25regulation of short-term neuronal synaptic plasticity (GO:0048172)4.12284360
26striatum development (GO:0021756)4.10166526
27positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.08715950
28cell communication by electrical coupling (GO:0010644)4.08285747
29negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.07730977
30melanin biosynthetic process (GO:0042438)4.05981118
31response to inactivity (GO:0014854)4.04296866
32cardiac myofibril assembly (GO:0055003)3.96296961
33prepulse inhibition (GO:0060134)3.92532718
34cell communication involved in cardiac conduction (GO:0086065)3.92313692
35secondary metabolite biosynthetic process (GO:0044550)3.87313516
36behavioral response to nicotine (GO:0035095)3.87095037
37negative regulation of potassium ion transmembrane transport (GO:1901380)3.86429649
38locomotory exploration behavior (GO:0035641)3.85479465
39inositol metabolic process (GO:0006020)3.82296003
40regulation of voltage-gated calcium channel activity (GO:1901385)3.81710253
41short-term memory (GO:0007614)3.81449945
42vocalization behavior (GO:0071625)3.80815540
43regulation of skeletal muscle contraction (GO:0014819)3.80514253
44negative regulation of lipid storage (GO:0010888)3.80181025
45detection of calcium ion (GO:0005513)3.79938242
46positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.77282011
47regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.76087557
48regulation of cell communication by electrical coupling (GO:0010649)3.74351054
49striated muscle contraction (GO:0006941)3.71932118
50ionotropic glutamate receptor signaling pathway (GO:0035235)3.71815123
51interkinetic nuclear migration (GO:0022027)3.71546993
52cardiac conduction (GO:0061337)3.69310636
53regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.68019015
54synapsis (GO:0007129)3.66098743
55adult heart development (GO:0007512)3.61721114
56synaptic vesicle maturation (GO:0016188)3.55739749
57regulation of glutamate receptor signaling pathway (GO:1900449)3.53196279
58regulation of actin filament-based movement (GO:1903115)3.52430170
59cardiac muscle contraction (GO:0060048)3.51792929
60response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.51343924
61melanin metabolic process (GO:0006582)3.50802812
62synaptic transmission, dopaminergic (GO:0001963)3.49908301
63glutamate receptor signaling pathway (GO:0007215)3.45619818
64positive regulation of potassium ion transmembrane transport (GO:1901381)3.44562637
65neuron-neuron synaptic transmission (GO:0007270)3.42385172
66regulation of heart rate by cardiac conduction (GO:0086091)3.38717149
67myofibril assembly (GO:0030239)3.38369358
68regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.38323966
69regulation of relaxation of muscle (GO:1901077)3.36150563
70cellular potassium ion homeostasis (GO:0030007)3.35140267
71synaptic transmission, glutamatergic (GO:0035249)3.34504214
72regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.31913567
73relaxation of cardiac muscle (GO:0055119)3.31300770
74sarcomere organization (GO:0045214)3.31295587
75G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.30397800
76membrane repolarization during action potential (GO:0086011)3.29676424
77regulation of the force of heart contraction (GO:0002026)3.29493855
78regulation of calcium ion transmembrane transporter activity (GO:1901019)3.28791699
79regulation of calcium ion transmembrane transport (GO:1903169)3.28791699
80ventricular cardiac muscle cell action potential (GO:0086005)3.25778614
81neurotransmitter-gated ion channel clustering (GO:0072578)3.24772251
82regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.24321119
83membrane depolarization during action potential (GO:0086010)3.23712817
84neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.22901812
85reflex (GO:0060004)3.22850724
86regulation of cardiac muscle cell contraction (GO:0086004)3.22223897
87multicellular organismal signaling (GO:0035637)3.22177198
88long-term memory (GO:0007616)3.22013515
89regulation of DNA endoreduplication (GO:0032875)3.21458865
90auditory behavior (GO:0031223)3.19659732
91positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.19579794
92synaptic vesicle docking involved in exocytosis (GO:0016081)3.19044313
93cardiac muscle cell action potential (GO:0086001)3.18477293
94potassium ion export (GO:0071435)3.18001879
95regulation of sequestering of triglyceride (GO:0010889)3.17951533
96synaptic vesicle exocytosis (GO:0016079)3.17378091
97regulation of excitatory postsynaptic membrane potential (GO:0060079)3.16552147
98positive regulation of potassium ion transport (GO:0043268)3.16489403
99cardiac muscle cell action potential involved in contraction (GO:0086002)3.15486392
100membrane repolarization (GO:0086009)3.15371558
101positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.14797542
102sodium ion export (GO:0071436)3.13308734
103behavioral response to cocaine (GO:0048148)3.11727070
104regulation of long-term neuronal synaptic plasticity (GO:0048169)3.11259731
105negative regulation of systemic arterial blood pressure (GO:0003085)3.09886799
106regulation of sarcomere organization (GO:0060297)3.08825001
107resolution of meiotic recombination intermediates (GO:0000712)3.08552121
108protein localization to synapse (GO:0035418)3.07513237
109negative chemotaxis (GO:0050919)3.07271092
110adenosine receptor signaling pathway (GO:0001973)3.05489818
111activation of protein kinase A activity (GO:0034199)3.04025460
112muscle cell cellular homeostasis (GO:0046716)3.03501653
113regulation of synaptic vesicle exocytosis (GO:2000300)3.02886396
114response to auditory stimulus (GO:0010996)3.02632658
115cardiac muscle cell development (GO:0055013)3.02199310
116positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.01947887
117regulation of postsynaptic membrane potential (GO:0060078)3.01843896
118regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.00617576
119response to muscle activity (GO:0014850)2.98446275
120positive regulation of synaptic transmission, GABAergic (GO:0032230)2.97179574
121positive regulation of neurotransmitter transport (GO:0051590)2.96724460
122positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.96407107
123regulation of cation channel activity (GO:2001257)2.96247788
124negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.95990978
125negative regulation of calcium ion transmembrane transport (GO:1903170)2.95990978
126membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.95007009
127neuronal action potential propagation (GO:0019227)2.94975360
128isoprenoid biosynthetic process (GO:0008299)2.92591797
129neurotransmitter secretion (GO:0007269)2.92380545
130actomyosin structure organization (GO:0031032)2.92161212
131potassium ion import (GO:0010107)2.91702795
132response to amphetamine (GO:0001975)2.90320840
133dopamine receptor signaling pathway (GO:0007212)2.89986683
134cAMP catabolic process (GO:0006198)2.89021910
135myotube differentiation (GO:0014902)2.88592788
136membrane hyperpolarization (GO:0060081)2.88551648
137regulation of neuronal synaptic plasticity (GO:0048168)2.88033380
138cardiac muscle hypertrophy (GO:0003300)2.87122699
139cAMP biosynthetic process (GO:0006171)2.86576667
140membrane depolarization (GO:0051899)2.86336036
141regulation of synaptic vesicle transport (GO:1902803)2.85131801
142regulation of synaptic transmission, glutamatergic (GO:0051966)2.84812370
143regulation of cardiac muscle contraction (GO:0055117)2.84535393
144actin filament-based movement (GO:0030048)2.83350649
145regulation of hippo signaling (GO:0035330)2.80959886
146response to caffeine (GO:0031000)2.80164572
147striated muscle hypertrophy (GO:0014897)2.79224269
148meiotic chromosome segregation (GO:0045132)2.73019714
149regulation of receptor biosynthetic process (GO:0010869)2.70932154
150regulation of potassium ion transmembrane transport (GO:1901379)2.69666046
151creatine metabolic process (GO:0006600)2.68914399
152skeletal muscle contraction (GO:0003009)2.67975299
153regulation of ATPase activity (GO:0043462)2.67901807
154regulation of ATP catabolic process (GO:1903289)2.67901807
155positive regulation of cation channel activity (GO:2001259)2.66423378
156protein K6-linked ubiquitination (GO:0085020)2.64248845
157male meiosis I (GO:0007141)2.62608590
158cellular ketone body metabolic process (GO:0046950)2.61878778
159cardiac cell development (GO:0055006)2.60847378
160ubiquinone biosynthetic process (GO:0006744)2.60606632
161retinol metabolic process (GO:0042572)2.60225020
162regulation of apoptotic cell clearance (GO:2000425)2.59407100
163regulation of striated muscle contraction (GO:0006942)2.59289800
164auditory receptor cell stereocilium organization (GO:0060088)2.58602998
165negative regulation of response to food (GO:0032096)2.56787658
166negative regulation of appetite (GO:0032099)2.56787658
167mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.56786066
168primary amino compound metabolic process (GO:1901160)2.50620110
169retinoic acid metabolic process (GO:0042573)2.49949894
170muscle contraction (GO:0006936)2.49924289
171kynurenine metabolic process (GO:0070189)2.49908162
172regulation of potassium ion transmembrane transporter activity (GO:1901016)2.49197800

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.73640673
2E2F7_22180533_ChIP-Seq_HELA_Human3.84635507
3VDR_22108803_ChIP-Seq_LS180_Human3.32983440
4GBX2_23144817_ChIP-Seq_PC3_Human3.13357063
5GATA1_22025678_ChIP-Seq_K562_Human3.10326458
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.79036611
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.74691024
8DROSHA_22980978_ChIP-Seq_HELA_Human2.61941963
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.60581623
10FUS_26573619_Chip-Seq_HEK293_Human2.47650783
11RARB_27405468_Chip-Seq_BRAIN_Mouse2.38733912
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.35243643
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.35243643
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.26004603
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.23916031
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.23775810
17RBPJ_22232070_ChIP-Seq_NCS_Mouse2.19284155
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.18709310
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.16284559
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.14474118
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.11017581
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.08694529
23REST_21632747_ChIP-Seq_MESCs_Mouse2.04711381
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.02725067
25EZH2_27294783_Chip-Seq_ESCs_Mouse2.02141668
26SMAD_19615063_ChIP-ChIP_OVARY_Human1.97712522
27RNF2_27304074_Chip-Seq_ESCs_Mouse1.94792803
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.92768815
29IKZF1_21737484_ChIP-ChIP_HCT116_Human1.85695113
30EED_16625203_ChIP-ChIP_MESCs_Mouse1.77277848
31EWS_26573619_Chip-Seq_HEK293_Human1.72005525
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.71374824
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.70993354
34MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.70811605
35KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.68893181
36EP300_21415370_ChIP-Seq_HL-1_Mouse1.67258973
37SMAD4_21799915_ChIP-Seq_A2780_Human1.63791752
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60376768
39RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.58066933
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57828248
41ZNF274_21170338_ChIP-Seq_K562_Hela1.56038453
42REST_18959480_ChIP-ChIP_MESCs_Mouse1.54012325
43TRIM28_21343339_ChIP-Seq_HEK293_Human1.52762624
44AR_21572438_ChIP-Seq_LNCaP_Human1.51445712
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.49289016
46CDX2_19796622_ChIP-Seq_MESCs_Mouse1.48951662
47MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.48095452
48SRF_21415370_ChIP-Seq_HL-1_Mouse1.46211120
49ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45333100
50EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41350817
51SALL1_21062744_ChIP-ChIP_HESCs_Human1.40663383
52E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.39308365
53KLF5_20875108_ChIP-Seq_MESCs_Mouse1.36157980
54CBP_20019798_ChIP-Seq_JUKART_Human1.35698012
55IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35698012
56VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.35484940
57EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.32757842
58HTT_18923047_ChIP-ChIP_STHdh_Human1.31187378
59PHF8_20622853_ChIP-Seq_HELA_Human1.29782759
60E2F4_17652178_ChIP-ChIP_JURKAT_Human1.28610260
61CTBP2_25329375_ChIP-Seq_LNCAP_Human1.28529728
62HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.28471204
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27272768
64NR3C1_23031785_ChIP-Seq_PC12_Mouse1.25242527
65SOX2_21211035_ChIP-Seq_LN229_Gbm1.25106292
66MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.24146423
67ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.23891494
68STAT3_23295773_ChIP-Seq_U87_Human1.23549719
69PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23415948
70TAL1_26923725_Chip-Seq_HPCs_Mouse1.23413976
71P53_22127205_ChIP-Seq_FIBROBLAST_Human1.22830849
72EZH2_27294783_Chip-Seq_NPCs_Mouse1.22200084
73TAF15_26573619_Chip-Seq_HEK293_Human1.22083913
74HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.21738601
75AHR_22903824_ChIP-Seq_MCF-7_Human1.20796725
76SMAD3_21741376_ChIP-Seq_EPCs_Human1.19618191
77SOX9_26525672_Chip-Seq_HEART_Mouse1.19586942
78P300_19829295_ChIP-Seq_ESCs_Human1.19204306
79MYC_18940864_ChIP-ChIP_HL60_Human1.18320352
80NFYB_21822215_ChIP-Seq_K562_Human1.18277952
81TCF4_23295773_ChIP-Seq_U87_Human1.17996355
82AR_19668381_ChIP-Seq_PC3_Human1.17845775
83WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17178742
84SMAD3_21741376_ChIP-Seq_HESCs_Human1.16782883
85TBL1_22424771_ChIP-Seq_293T_Human1.16676030
86GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.16568331
87ETV1_20927104_ChIP-Seq_GIST48_Human1.16053359
88JUN_21703547_ChIP-Seq_K562_Human1.15648419
89GATA2_19941826_ChIP-Seq_K562_Human1.14961181
90FLI1_27457419_Chip-Seq_LIVER_Mouse1.14064045
91TP53_16413492_ChIP-PET_HCT116_Human1.13798300
92MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13602624
93AUTS2_25519132_ChIP-Seq_293T-REX_Human1.11825387
94RNF2_27304074_Chip-Seq_NSC_Mouse1.11222164
95OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11181220
96GATA4_21415370_ChIP-Seq_HL-1_Mouse1.10858899
97RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10758535
98ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.10703165
99BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10673773
100TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10502790
101PIAS1_25552417_ChIP-Seq_VCAP_Human1.10101023
102ARNT_22903824_ChIP-Seq_MCF-7_Human1.09942164
103ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09419387
104GATA1_19941826_ChIP-Seq_K562_Human1.09352856
105ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.08829488
106CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.08727356
107PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.08420036
108SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08350989
109RING1B_27294783_Chip-Seq_ESCs_Mouse1.08319946
110CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.07562639
111ETV2_25802403_ChIP-Seq_MESCs_Mouse1.07473324
112AR_25329375_ChIP-Seq_VCAP_Human1.07280036
113CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06733837
114MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06711126
115PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.06597357
116EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.06433086
117EST1_17652178_ChIP-ChIP_JURKAT_Human1.06401659
118AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05624742
119CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05521114
120TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05088218
121GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04806943
122LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03628189
123TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03277857
124POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03277857
125STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.03275958
126TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03083759
127HNFA_21074721_ChIP-Seq_CACO-2_Human1.02447345
128SMAD4_21741376_ChIP-Seq_EPCs_Human1.02362457
129CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01499124
130POU3F2_20337985_ChIP-ChIP_501MEL_Human1.01364005
131CBX2_22325352_ChIP-Seq_293T-Rex_Human1.01101398
132FOXM1_23109430_ChIP-Seq_U2OS_Human1.00690654
133SMAD4_21741376_ChIP-Seq_HESCs_Human1.00066543
134BCAT_22108803_ChIP-Seq_LS180_Human0.99931633
135RBPJ_21746931_ChIP-Seq_IB4_Human0.99750366
136ESR1_20079471_ChIP-ChIP_T-47D_Human0.99717084
137NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99656809
138P53_22387025_ChIP-Seq_ESCs_Mouse0.99131432
139RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.98480065
140ELK1_19687146_ChIP-ChIP_HELA_Human0.98384587
141NCOR_22424771_ChIP-Seq_293T_Human0.98102094
142CDX2_22108803_ChIP-Seq_LS180_Human0.97635797
143TBX20_22080862_ChIP-Seq_HEART_Mouse0.97446128
144TBX20_22328084_ChIP-Seq_HEART_Mouse0.97446128
145TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96921663
146TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96630955
147RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.96264242
148SOX2_19829295_ChIP-Seq_ESCs_Human0.96248166
149NANOG_19829295_ChIP-Seq_ESCs_Human0.96248166
150NFYA_21822215_ChIP-Seq_K562_Human0.95943270
151UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94451049
152SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94380542
153IGF1R_20145208_ChIP-Seq_DFB_Human0.94172257
154E2F1_18555785_Chip-Seq_ESCs_Mouse0.93833112
155PRDM14_20953172_ChIP-Seq_ESCs_Human0.93754223
156KDM2B_26808549_Chip-Seq_K562_Human0.93529765
157ER_23166858_ChIP-Seq_MCF-7_Human0.93404933
158GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93359463
159NANOG_18555785_Chip-Seq_ESCs_Mouse0.93335743
160CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.93210619
161YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91786959
162RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.91656995
163RUNX2_22187159_ChIP-Seq_PCA_Human0.90832405
164THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.89788307
165CBX2_27304074_Chip-Seq_ESCs_Mouse0.89524110

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation5.18261348
2MP0002822_catalepsy4.85883797
3MP0004859_abnormal_synaptic_plasticity4.57466760
4MP0002837_dystrophic_cardiac_calcinosis3.45713033
5MP0004215_abnormal_myocardial_fiber3.35746216
6MP0003880_abnormal_central_pattern3.30651320
7MP0005171_absent_coat_pigmentation3.22991543
8MP0004084_abnormal_cardiac_muscle3.20297298
9MP0000372_irregular_coat_pigmentation3.17288155
10MP0003635_abnormal_synaptic_transmissio3.11421375
11MP0004510_myositis3.03711820
12MP0009046_muscle_twitch3.02781847
13MP0003646_muscle_fatigue2.96019504
14MP0000751_myopathy2.88315996
15MP0009745_abnormal_behavioral_response2.82767254
16MP0005377_hearing/vestibular/ear_phenot2.58168656
17MP0003878_abnormal_ear_physiology2.58168656
18MP0004036_abnormal_muscle_relaxation2.52333924
19MP0002063_abnormal_learning/memory/cond2.50025063
20MP0005248_abnormal_Harderian_gland2.44024945
21MP0002064_seizures2.31204809
22MP0003136_yellow_coat_color2.29999047
23MP0003137_abnormal_impulse_conducting2.28488181
24MP0005423_abnormal_somatic_nervous2.22956266
25MP0001486_abnormal_startle_reflex2.20875202
26MP0002272_abnormal_nervous_system2.16551819
27MP0003950_abnormal_plasma_membrane2.16205478
28MP0002638_abnormal_pupillary_reflex2.12531509
29MP0002572_abnormal_emotion/affect_behav2.09392726
30MP0004147_increased_porphyrin_level2.08990424
31MP0004270_analgesia2.04344683
32MP0002102_abnormal_ear_morphology1.95660594
33MP0002972_abnormal_cardiac_muscle1.95363143
34MP0008569_lethality_at_weaning1.91757202
35MP0001968_abnormal_touch/_nociception1.89128403
36MP0004085_abnormal_heartbeat1.88097368
37MP0005330_cardiomyopathy1.87380030
38MP0008775_abnormal_heart_ventricle1.84539227
39MP0005408_hypopigmentation1.84047526
40MP0005187_abnormal_penis_morphology1.80692455
41MP0009697_abnormal_copulation1.79262889
42MP0005386_behavior/neurological_phenoty1.74118201
43MP0004924_abnormal_behavior1.74118201
44MP0001501_abnormal_sleep_pattern1.71215523
45MP0005253_abnormal_eye_physiology1.70551437
46MP0002909_abnormal_adrenal_gland1.68143560
47MP0005620_abnormal_muscle_contractility1.67575925
48MP0001324_abnormal_eye_pigmentation1.64204267
49MP0002254_reproductive_system_inflammat1.59031292
50MP0004145_abnormal_muscle_electrophysio1.58834578
51MP0004484_altered_response_of1.58648578
52MP0002067_abnormal_sensory_capabilities1.55590604
53MP0000371_diluted_coat_color1.50945219
54MP0002095_abnormal_skin_pigmentation1.50179872
55MP0005646_abnormal_pituitary_gland1.47531858
56MP0004087_abnormal_muscle_fiber1.46755642
57MP0000749_muscle_degeneration1.45771119
58MP0000747_muscle_weakness1.45561738
59MP0002734_abnormal_mechanical_nocicepti1.44075927
60MP0001529_abnormal_vocalization1.43633268
61MP0003879_abnormal_hair_cell1.41435972
62MP0002735_abnormal_chemical_nociception1.40893558
63MP0001440_abnormal_grooming_behavior1.40761172
64MP0006138_congestive_heart_failure1.38535773
65MP0003300_gastrointestinal_ulcer1.37960789
66MP0001544_abnormal_cardiovascular_syste1.37658343
67MP0005385_cardiovascular_system_phenoty1.37658343
68MP0004130_abnormal_muscle_cell1.32682679
69MP0001984_abnormal_olfaction1.31805619
70MP0001188_hyperpigmentation1.30741764
71MP0000569_abnormal_digit_pigmentation1.26633981
72MP0001970_abnormal_pain_threshold1.25344190
73MP0002184_abnormal_innervation1.25287740
74MP0002106_abnormal_muscle_physiology1.23377407
75MP0002736_abnormal_nociception_after1.22339753
76MP0002557_abnormal_social/conspecific_i1.22007906
77MP0006036_abnormal_mitochondrial_physio1.19339851
78MP0005551_abnormal_eye_electrophysiolog1.18759851
79MP0005409_darkened_coat_color1.15973944
80MP0001502_abnormal_circadian_rhythm1.14518272
81MP0003656_abnormal_erythrocyte_physiolo1.12864627
82MP0002075_abnormal_coat/hair_pigmentati1.07530535
83MP0010630_abnormal_cardiac_muscle1.07162530
84MP0005257_abnormal_intraocular_pressure1.04099615
85MP0002733_abnormal_thermal_nociception1.03216863
86MP0003828_pulmonary_edema1.00741157
87MP0002066_abnormal_motor_capabilities/c1.00190256
88MP0001661_extended_life_span0.99679543
89MP0004811_abnormal_neuron_physiology0.98846986
90MP0005195_abnormal_posterior_eye0.97468189
91MP0005369_muscle_phenotype0.96068714
92MP0002090_abnormal_vision0.95586611
93MP0005645_abnormal_hypothalamus_physiol0.94218695
94MP0001348_abnormal_lacrimal_gland0.94003743
95MP0008872_abnormal_physiological_respon0.92669743
96MP0005174_abnormal_tail_pigmentation0.92130684
97MP0008874_decreased_physiological_sensi0.91189643
98MP0004185_abnormal_adipocyte_glucose0.91117929
99MP0002127_abnormal_cardiovascular_syste0.90570085
100MP0002877_abnormal_melanocyte_morpholog0.90099095
101MP0002882_abnormal_neuron_morphology0.89702491
102MP0010094_abnormal_chromosome_stability0.88872545
103MP0002160_abnormal_reproductive_system0.88517973
104MP0003787_abnormal_imprinting0.88255827
105MP0000465_gastrointestinal_hemorrhage0.87780323
106MP0003633_abnormal_nervous_system0.87681557
107MP0005535_abnormal_body_temperature0.86059639
108MP0000778_abnormal_nervous_system0.85519117
109MP0005197_abnormal_uvea_morphology0.85448389
110MP0005310_abnormal_salivary_gland0.85086763
111MP0005083_abnormal_biliary_tract0.84740028
112MP0009780_abnormal_chondrocyte_physiolo0.83932910
113MP0004142_abnormal_muscle_tone0.82891556
114MP0004233_abnormal_muscle_weight0.82483083
115MP0002938_white_spotting0.81625865
116MP0000383_abnormal_hair_follicle0.80903716
117MP0008058_abnormal_DNA_repair0.78678988
118MP0004043_abnormal_pH_regulation0.77887503
119MP0004134_abnormal_chest_morphology0.75932926
120MP0010386_abnormal_urinary_bladder0.75808399
121MP0002229_neurodegeneration0.75232667
122MP0000759_abnormal_skeletal_muscle0.75160443
123MP0001485_abnormal_pinna_reflex0.74842697
124MP0002269_muscular_atrophy0.74349150
125MP0003045_fibrosis0.74272610
126MP0001346_abnormal_lacrimal_gland0.73449833
127MP0001186_pigmentation_phenotype0.72744421
128MP0008995_early_reproductive_senescence0.72371101
129MP0005266_abnormal_metabolism0.72222363
130MP0000013_abnormal_adipose_tissue0.72196713
131MP0002138_abnormal_hepatobiliary_system0.72012265
132MP0002234_abnormal_pharynx_morphology0.71975892
133MP0003890_abnormal_embryonic-extraembry0.71850707
134MP0006072_abnormal_retinal_apoptosis0.71490086
135MP0000955_abnormal_spinal_cord0.70230970
136MP0000647_abnormal_sebaceous_gland0.70139160
137MP0004858_abnormal_nervous_system0.69904895
138MP0005391_vision/eye_phenotype0.68421388
139MP0003631_nervous_system_phenotype0.67454076
140MP0003786_premature_aging0.66616182
141MP0006035_abnormal_mitochondrial_morpho0.65754634
142MP0000230_abnormal_systemic_arterial0.65676768
143MP0005167_abnormal_blood-brain_barrier0.65434161
144MP0000750_abnormal_muscle_regeneration0.65214706
145MP0000015_abnormal_ear_pigmentation0.64916931
146MP0000631_abnormal_neuroendocrine_gland0.64571915
147MP0008961_abnormal_basal_metabolism0.63895275
148MP0006276_abnormal_autonomic_nervous0.62449964
149MP0004885_abnormal_endolymph0.61375385
150MP0004742_abnormal_vestibular_system0.61250644
151MP0002332_abnormal_exercise_endurance0.60958320
152MP0000733_abnormal_muscle_development0.60603267
153MP0003937_abnormal_limbs/digits/tail_de0.58913972
154MP0002752_abnormal_somatic_nervous0.58603568

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)6.29900345
2Abnormality of the fovea (HP:0000493)5.93349237
3Atrial fibrillation (HP:0005110)5.65661512
4Muscle fiber inclusion bodies (HP:0100299)5.59593095
5Focal motor seizures (HP:0011153)5.48379375
6Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.46171158
7Prolonged QT interval (HP:0001657)5.45494853
8Primary atrial arrhythmia (HP:0001692)5.35518605
9Myokymia (HP:0002411)5.33039402
10Nemaline bodies (HP:0003798)5.28616413
11Syncope (HP:0001279)5.15314914
12Supraventricular tachycardia (HP:0004755)5.06644415
13Supraventricular arrhythmia (HP:0005115)4.91871839
14Ventricular fibrillation (HP:0001663)4.80195445
15Bundle branch block (HP:0011710)4.44396227
16Choroideremia (HP:0001139)4.37551709
17Abnormal EKG (HP:0003115)4.33579030
18Focal seizures (HP:0007359)4.06595750
19Ventricular tachycardia (HP:0004756)3.93656967
20Febrile seizures (HP:0002373)3.84436444
21Subaortic stenosis (HP:0001682)3.82365962
22Abnormality of the left ventricular outflow tract (HP:0011103)3.82365962
23Gaze-evoked nystagmus (HP:0000640)3.77455250
24Dysmetric saccades (HP:0000641)3.75738485
25Ventricular arrhythmia (HP:0004308)3.71287455
26Heart block (HP:0012722)3.67845903
27Exercise-induced myalgia (HP:0003738)3.55706922
28Visual hallucinations (HP:0002367)3.54520908
29Calf muscle hypertrophy (HP:0008981)3.52949007
30Type 1 muscle fiber predominance (HP:0003803)3.46225598
31Progressive cerebellar ataxia (HP:0002073)3.42492809
32Action tremor (HP:0002345)3.40462318
33Dysdiadochokinesis (HP:0002075)3.39272633
34Atrioventricular block (HP:0001678)3.36490822
35Abnormal atrioventricular conduction (HP:0005150)3.34494506
36Abnormality of the calf musculature (HP:0001430)3.30545590
37Epileptic encephalopathy (HP:0200134)3.25273917
38Abnormal rod and cone electroretinograms (HP:0008323)3.23659035
39Muscle hypertrophy of the lower extremities (HP:0008968)3.13948051
40Bony spicule pigmentary retinopathy (HP:0007737)3.07173571
41Central scotoma (HP:0000603)3.03578627
42Hypoplasia of the fovea (HP:0007750)3.02730547
43Aplasia/Hypoplasia of the fovea (HP:0008060)3.02730547
44Lipoatrophy (HP:0100578)3.00491031
45Broad-based gait (HP:0002136)2.97802166
46Absence seizures (HP:0002121)2.93224471
47Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.92647914
48Abnormality of alanine metabolism (HP:0010916)2.92647914
49Hyperalaninemia (HP:0003348)2.92647914
50Poor eye contact (HP:0000817)2.86333437
51Palpitations (HP:0001962)2.79483902
52Hypopigmentation of the fundus (HP:0007894)2.78960805
53Rimmed vacuoles (HP:0003805)2.73790582
54Left ventricular hypertrophy (HP:0001712)2.72216340
55Right ventricular cardiomyopathy (HP:0011663)2.71997896
56Anxiety (HP:0000739)2.69891082
57Dilated cardiomyopathy (HP:0001644)2.69498597
58Atonic seizures (HP:0010819)2.67771147
59Dialeptic seizures (HP:0011146)2.67426041
60Generalized tonic-clonic seizures (HP:0002069)2.65569608
61Exercise-induced muscle cramps (HP:0003710)2.54677007
62Abnormal social behavior (HP:0012433)2.53320808
63Impaired social interactions (HP:0000735)2.53320808
64Lower limb amyotrophy (HP:0007210)2.50462023
65Severe visual impairment (HP:0001141)2.50299195
66Depression (HP:0000716)2.49777665
67Truncal ataxia (HP:0002078)2.46713439
68Congenital stationary night blindness (HP:0007642)2.45828271
69Pendular nystagmus (HP:0012043)2.42095199
70Impaired smooth pursuit (HP:0007772)2.39055590
71Dysmetria (HP:0001310)2.37853540
72Scanning speech (HP:0002168)2.37570311
73Annular pancreas (HP:0001734)2.29503955
74Genetic anticipation (HP:0003743)2.27222478
75Pheochromocytoma (HP:0002666)2.22893965
76Aplasia/Hypoplasia of the macula (HP:0008059)2.22002703
77Myopathic facies (HP:0002058)2.20539523
78Urinary bladder sphincter dysfunction (HP:0002839)2.19544611
79Muscle fiber splitting (HP:0003555)2.18939662
80Myotonia (HP:0002486)2.18828978
81Hyporeflexia of lower limbs (HP:0002600)2.17563854
82Impaired vibration sensation in the lower limbs (HP:0002166)2.17265044
83Hemiplegia (HP:0002301)2.16221254
84Macular degeneration (HP:0000608)2.15599214
85Colon cancer (HP:0003003)2.15577253
86Optic nerve hypoplasia (HP:0000609)2.14860379
87Acute necrotizing encephalopathy (HP:0006965)2.13104169
88Abnormality of the renal collecting system (HP:0004742)2.11914693
89Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.10170045
90Homocystinuria (HP:0002156)2.09367931
91Abnormality of homocysteine metabolism (HP:0010919)2.09367931
92Abnormality of ocular smooth pursuit (HP:0000617)2.09098997
93EMG: myopathic abnormalities (HP:0003458)2.08755868
94Distal lower limb amyotrophy (HP:0008944)2.08732599
95Tinnitus (HP:0000360)2.07997578
96Progressive inability to walk (HP:0002505)2.06246868
97Rhabdomyolysis (HP:0003201)2.05609835
98Asymmetric septal hypertrophy (HP:0001670)2.05526640
99Chromsome breakage (HP:0040012)2.04226228
100Aplasia/Hypoplasia affecting the retina (HP:0008061)2.03709589
101Chromosomal breakage induced by crosslinking agents (HP:0003221)2.02766535
102Ankle clonus (HP:0011448)2.02582072
103Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.02371485
104Abnormal mitochondria in muscle tissue (HP:0008316)2.02338362
105Stereotypic behavior (HP:0000733)2.01809327
106Paralysis (HP:0003470)2.01081930
107Acute encephalopathy (HP:0006846)2.00915474
108Abnormality of saccadic eye movements (HP:0000570)2.00275790
109Ocular albinism (HP:0001107)1.99574856
110EMG: neuropathic changes (HP:0003445)1.97496500
111Hyperventilation (HP:0002883)1.97339766
112Torticollis (HP:0000473)1.96946442
113Bilateral sensorineural hearing impairment (HP:0008619)1.93358316
114Postural instability (HP:0002172)1.93053182
115Pancreatic fibrosis (HP:0100732)1.92191388
116Neuroendocrine neoplasm (HP:0100634)1.91542186
117Truncus arteriosus (HP:0001660)1.91357505
118Generalized muscle weakness (HP:0003324)1.90148128
119Sudden cardiac death (HP:0001645)1.89000163
120Poikilocytosis (HP:0004447)1.88833095
121Areflexia of lower limbs (HP:0002522)1.87419833
122Bradycardia (HP:0001662)1.87323986
123Myoglobinuria (HP:0002913)1.87146063
124Scotoma (HP:0000575)1.86617241
125Pointed chin (HP:0000307)1.85945573
126Blue irides (HP:0000635)1.85137998
127Neck muscle weakness (HP:0000467)1.84955080
128Type II lissencephaly (HP:0007260)1.83340041
129Distal arthrogryposis (HP:0005684)1.83312945
130Increased serum pyruvate (HP:0003542)1.83108195
131Absent phalangeal crease (HP:0006109)1.81272459
132Congenital sensorineural hearing impairment (HP:0008527)1.80814870
133Methylmalonic acidemia (HP:0002912)1.80541631
134Abolished electroretinogram (ERG) (HP:0000550)1.80024856
135Horizontal nystagmus (HP:0000666)1.80003713
136Progressive macrocephaly (HP:0004481)1.79515385
137Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.79431151
138Hemiparesis (HP:0001269)1.78097164
139Congenital malformation of the right heart (HP:0011723)1.77675606
140Double outlet right ventricle (HP:0001719)1.77675606
141Frequent falls (HP:0002359)1.77176822
1423-Methylglutaconic aciduria (HP:0003535)1.74833572
143Abnormality of DNA repair (HP:0003254)1.74592283
144Reticulocytosis (HP:0001923)1.73760316
145Albinism (HP:0001022)1.73640193
146Abnormality of the periventricular white matter (HP:0002518)1.71912824
147Iris hypopigmentation (HP:0007730)1.70655527
148Cholecystitis (HP:0001082)1.70289943
149Abnormal gallbladder physiology (HP:0012438)1.70289943
150Beaking of vertebral bodies (HP:0004568)1.70184324
151Nephronophthisis (HP:0000090)1.69171921
152Abnormality of macular pigmentation (HP:0008002)1.68984850
153Resting tremor (HP:0002322)1.68934757
154Pancreatic cysts (HP:0001737)1.68463009
155Duplicated collecting system (HP:0000081)1.68225806
156Aplasia/Hypoplasia of the uvula (HP:0010293)1.67467127
157Abnormality of glycolysis (HP:0004366)1.66746681
158Palpebral edema (HP:0100540)1.65150553
159Intention tremor (HP:0002080)1.63946213
160Urinary urgency (HP:0000012)1.59996193
161Incomplete penetrance (HP:0003829)1.58399000
162Spinal canal stenosis (HP:0003416)1.55362324
163Impaired vibratory sensation (HP:0002495)1.54994998
164Focal dystonia (HP:0004373)1.54487502
165Difficulty running (HP:0009046)1.53395474
166Pulmonary artery stenosis (HP:0004415)1.51508287
167Dyschromatopsia (HP:0007641)1.48309614

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.69276301
2MST1R4.49876009
3NTRK33.44655217
4MAP3K132.70463911
5MET2.65885394
6RIPK42.34804899
7LMTK22.32898751
8WNK42.23413964
9CAMKK12.16693276
10MAP3K42.09359314
11PHKG22.04992337
12PHKG12.04992337
13MAP3K92.01592047
14DMPK1.88174412
15MAP2K71.86109081
16STK381.79898161
17CAMKK21.79849775
18PINK11.73804151
19CDC71.68927685
20PRKD31.68274246
21TRPM71.66786800
22MARK31.65740517
23DAPK21.64282810
24MAP3K141.64076503
25BMX1.58688229
26PAK61.58069985
27NTRK21.57844396
28EIF2AK11.57161978
29WNK11.56581571
30FRK1.55053143
31ADRBK21.54572870
32SGK21.46788751
33NME11.46700703
34MINK11.46349185
35TNIK1.43134705
36DDR21.42742204
37MARK11.42539335
38KSR21.38937444
39BMPR21.37293349
40PRPF4B1.33818672
41STK241.31374969
42PNCK1.30413180
43TTK1.27616562
44MYLK1.26671989
45BRSK21.25725087
46STK38L1.24794736
47STK391.22001253
48WEE11.21452699
49INSRR1.19822115
50PDK41.19214284
51PDK31.19214284
52RIPK11.18940303
53SGK31.18377486
54CDK51.18346086
55SIK21.17022924
56MUSK1.14868968
57SGK11.14695782
58CAMK2A1.13632188
59SGK4941.12347912
60SGK2231.12347912
61BMPR1B1.11512820
62CAMK2D1.09251593
63CDC42BPA1.07855114
64OBSCN1.06959665
65CAMK11.06511786
66CAMK41.05878444
67KSR11.04875554
68CLK11.04594493
69PLK41.03062287
70SIK30.99035003
71ARAF0.98553264
72PRKAA20.97488665
73PKN10.96395656
74MAPK130.95339672
75TTN0.93770543
76FES0.92118072
77STK110.90420120
78GRK70.90025843
79STK30.89056999
80PTK2B0.88845083
81MAP2K10.87760710
82MAP2K40.87756487
83PAK30.86885928
84JAK10.82913513
85PRKCE0.82752277
86CSNK1A1L0.81691357
87PDK10.81566874
88CCNB10.81512761
89CSNK1G20.79203565
90RET0.79024054
91PIK3CG0.78941011
92CSNK1G30.77877041
93NEK10.75127145
94MAP3K70.71143036
95PRKCH0.69661366
96CSNK1G10.67372605
97PRKAA10.64779372
98TLK10.63948576
99CASK0.63938680
100PDK20.63902280
101MAPKAPK30.63268083
102CHEK20.62765769
103NTRK10.62386220
104MAP2K60.62006273
105GRK50.61957662
106WNK30.60970835
107PIK3CA0.60267605
108PLK10.59138166
109RAF10.58934620
110CAMK2B0.58437525
111GRK10.58091987
112ZAK0.56993127
113PRKCG0.56859518
114DAPK10.56774863
115TIE10.56742143
116STK160.56335195
117IKBKE0.56012781
118PDPK10.55973058
119OXSR10.54712445
120MAP3K120.54522051
121RPS6KA30.53943556
122ROCK10.53290981
123CAMK2G0.52757118
124ACVR1B0.52530432
125MAPK120.52085711
126UHMK10.51883221
127PLK20.51248830
128PRKACA0.50756783
129ERBB30.50380308
130PRKCZ0.50321752
131PRKD10.49057007
132PRKACG0.48349672
133NEK60.48156849
134TAOK10.47916829
135LATS10.47227662
136NUAK10.47174794
137ABL20.46800582
138PLK30.46793968
139MAP3K20.45848537
140BUB10.45597492
141NEK90.45163581
142PRKCQ0.44602134
143MAP3K10.43402895
144IKBKB0.43372453
145TYRO30.41453339
146ATM0.41226723
147TSSK60.40414784
148PRKCB0.40356687
149CAMK1G0.40258249
150TEC0.36585185
151ERBB40.36569224
152ATR0.35813367
153MAP4K20.33582212
154BRSK10.31873380
155MKNK20.30054490
156IRAK30.29591033
157MAPKAPK50.28626482

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.87463573
2Olfactory transduction_Homo sapiens_hsa047402.85052962
3Morphine addiction_Homo sapiens_hsa050322.59896697
4Circadian entrainment_Homo sapiens_hsa047132.55457023
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.41771453
6Glutamatergic synapse_Homo sapiens_hsa047242.33832426
7GABAergic synapse_Homo sapiens_hsa047272.33737918
8Cardiac muscle contraction_Homo sapiens_hsa042602.29812891
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.27495397
10Dilated cardiomyopathy_Homo sapiens_hsa054142.22633402
11Homologous recombination_Homo sapiens_hsa034402.22524634
12One carbon pool by folate_Homo sapiens_hsa006702.22050781
13Long-term potentiation_Homo sapiens_hsa047202.18468987
14Amphetamine addiction_Homo sapiens_hsa050312.12503225
15Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.04512690
16Pyruvate metabolism_Homo sapiens_hsa006202.00108214
17Salivary secretion_Homo sapiens_hsa049701.90791257
18Synaptic vesicle cycle_Homo sapiens_hsa047211.89403404
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.86785408
20Renin secretion_Homo sapiens_hsa049241.86618984
21Cholinergic synapse_Homo sapiens_hsa047251.86244563
22Tyrosine metabolism_Homo sapiens_hsa003501.82267682
23Phenylalanine metabolism_Homo sapiens_hsa003601.81471889
24Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.79577531
25Calcium signaling pathway_Homo sapiens_hsa040201.78661324
26Taste transduction_Homo sapiens_hsa047421.77171652
27beta-Alanine metabolism_Homo sapiens_hsa004101.76961603
28Oxytocin signaling pathway_Homo sapiens_hsa049211.76755558
29Nitrogen metabolism_Homo sapiens_hsa009101.75180746
30Dopaminergic synapse_Homo sapiens_hsa047281.73874538
31Insulin secretion_Homo sapiens_hsa049111.72817527
32Fanconi anemia pathway_Homo sapiens_hsa034601.71729461
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.70448927
34Gastric acid secretion_Homo sapiens_hsa049711.70447290
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.62558815
36Propanoate metabolism_Homo sapiens_hsa006401.62299907
37Cocaine addiction_Homo sapiens_hsa050301.56999895
38Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.49999476
39cAMP signaling pathway_Homo sapiens_hsa040241.46764941
40Serotonergic synapse_Homo sapiens_hsa047261.45317020
41Butanoate metabolism_Homo sapiens_hsa006501.45288744
42Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.45214402
43cGMP-PKG signaling pathway_Homo sapiens_hsa040221.37899879
44Type II diabetes mellitus_Homo sapiens_hsa049301.37573511
45Long-term depression_Homo sapiens_hsa047301.35323569
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.35240954
47Phosphatidylinositol signaling system_Homo sapiens_hsa040701.26810802
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.26770628
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.26320729
50GnRH signaling pathway_Homo sapiens_hsa049121.25954586
51Nucleotide excision repair_Homo sapiens_hsa034201.25518319
52Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.24555120
53Mismatch repair_Homo sapiens_hsa034301.22905259
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.22289270
55Phototransduction_Homo sapiens_hsa047441.19881443
56Tryptophan metabolism_Homo sapiens_hsa003801.18359186
57DNA replication_Homo sapiens_hsa030301.17661715
58Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17529364
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14782253
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.13757191
61Gap junction_Homo sapiens_hsa045401.10085551
62Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.09304184
63Vascular smooth muscle contraction_Homo sapiens_hsa042701.08504555
64Carbon metabolism_Homo sapiens_hsa012001.00079526
65Basal transcription factors_Homo sapiens_hsa030220.99948917
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98225194
67RNA degradation_Homo sapiens_hsa030180.97702799
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.95942479
69Arginine and proline metabolism_Homo sapiens_hsa003300.95622092
70Selenocompound metabolism_Homo sapiens_hsa004500.93522381
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.92955732
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92366800
73Dorso-ventral axis formation_Homo sapiens_hsa043200.91695765
74Melanoma_Homo sapiens_hsa052180.88937104
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.88438776
76Histidine metabolism_Homo sapiens_hsa003400.87255961
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86968757
78Estrogen signaling pathway_Homo sapiens_hsa049150.85417027
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84344148
80Pancreatic secretion_Homo sapiens_hsa049720.84220189
81Parkinsons disease_Homo sapiens_hsa050120.82778772
82ABC transporters_Homo sapiens_hsa020100.81425435
83Circadian rhythm_Homo sapiens_hsa047100.80128220
84Steroid biosynthesis_Homo sapiens_hsa001000.79692843
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.79546842
86Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.79512800
87Retinol metabolism_Homo sapiens_hsa008300.76627082
88MAPK signaling pathway_Homo sapiens_hsa040100.75056750
89Arginine biosynthesis_Homo sapiens_hsa002200.74562943
90Alzheimers disease_Homo sapiens_hsa050100.73607817
91Chemokine signaling pathway_Homo sapiens_hsa040620.73536993
92Glioma_Homo sapiens_hsa052140.70365183
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69374153
94ErbB signaling pathway_Homo sapiens_hsa040120.68983357
95RNA polymerase_Homo sapiens_hsa030200.68569312
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67875228
97Inositol phosphate metabolism_Homo sapiens_hsa005620.66749255
98Melanogenesis_Homo sapiens_hsa049160.65492116
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65098524
100Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.64898280
101Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.64757204
102Peroxisome_Homo sapiens_hsa041460.64581504
103Protein export_Homo sapiens_hsa030600.64233334
104ECM-receptor interaction_Homo sapiens_hsa045120.63371615
105Choline metabolism in cancer_Homo sapiens_hsa052310.62725488
106Biosynthesis of amino acids_Homo sapiens_hsa012300.62468745
107Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.62321724
108Sulfur metabolism_Homo sapiens_hsa009200.62253398
109Ovarian steroidogenesis_Homo sapiens_hsa049130.60961547
110RNA transport_Homo sapiens_hsa030130.60755908
111African trypanosomiasis_Homo sapiens_hsa051430.60379570
112Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.59991053
113Type I diabetes mellitus_Homo sapiens_hsa049400.59217646
114Glucagon signaling pathway_Homo sapiens_hsa049220.59163038
115Mineral absorption_Homo sapiens_hsa049780.58957161
116Metabolic pathways_Homo sapiens_hsa011000.58627919
117Steroid hormone biosynthesis_Homo sapiens_hsa001400.56593555
118Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55827707
119Axon guidance_Homo sapiens_hsa043600.54618147
120Cell cycle_Homo sapiens_hsa041100.54587077
121Linoleic acid metabolism_Homo sapiens_hsa005910.52550738
122VEGF signaling pathway_Homo sapiens_hsa043700.52396166
123Thyroid hormone synthesis_Homo sapiens_hsa049180.50998567
124Purine metabolism_Homo sapiens_hsa002300.50609623
125Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50361073
126mTOR signaling pathway_Homo sapiens_hsa041500.49947010
127Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49560084
128Adipocytokine signaling pathway_Homo sapiens_hsa049200.49513201
129Maturity onset diabetes of the young_Homo sapiens_hsa049500.49450157
130Fructose and mannose metabolism_Homo sapiens_hsa000510.49024448
131Viral myocarditis_Homo sapiens_hsa054160.48931326
132Fatty acid metabolism_Homo sapiens_hsa012120.48384233
133Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48283908
134Non-small cell lung cancer_Homo sapiens_hsa052230.47708102
135Rap1 signaling pathway_Homo sapiens_hsa040150.47643673
136Neurotrophin signaling pathway_Homo sapiens_hsa047220.46920823
137Ras signaling pathway_Homo sapiens_hsa040140.46909307
138Insulin signaling pathway_Homo sapiens_hsa049100.46060282
139Osteoclast differentiation_Homo sapiens_hsa043800.44257723
140Oxidative phosphorylation_Homo sapiens_hsa001900.44158323
141Insulin resistance_Homo sapiens_hsa049310.43900744
142Fatty acid biosynthesis_Homo sapiens_hsa000610.42798416
1432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.42346246
144Collecting duct acid secretion_Homo sapiens_hsa049660.40699171
145Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40261082
146HIF-1 signaling pathway_Homo sapiens_hsa040660.37829105
147Ether lipid metabolism_Homo sapiens_hsa005650.37486481
148Oocyte meiosis_Homo sapiens_hsa041140.35800022
149Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.34991105
150Sulfur relay system_Homo sapiens_hsa041220.34517549
151Huntingtons disease_Homo sapiens_hsa050160.34167993
152Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34012150
153Platelet activation_Homo sapiens_hsa046110.33941590
154Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33639398
155Sphingolipid signaling pathway_Homo sapiens_hsa040710.33540880
156Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33299823
157Prolactin signaling pathway_Homo sapiens_hsa049170.31559273
158Endometrial cancer_Homo sapiens_hsa052130.29802927
159Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.28551294
160Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.28537576
161TNF signaling pathway_Homo sapiens_hsa046680.27304005
162Alcoholism_Homo sapiens_hsa050340.26408274
163Toxoplasmosis_Homo sapiens_hsa051450.25027448

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