STON2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which is a membrane protein involved in regulating endocytotic complexes. The protein product is described as one of the clathrin-associated sorting proteins, adaptor molecules which ensure specific proteins are internalized. The encoded protein has also been shown to participate in synaptic vesicle recycling through interaction with synaptotagmin 1 required for neurotransmission. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)5.24113411
2DNA double-strand break processing (GO:0000729)5.18261742
3pre-miRNA processing (GO:0031054)4.64075716
4regulation of sister chromatid cohesion (GO:0007063)4.17794754
5paraxial mesoderm development (GO:0048339)4.14114574
6monoubiquitinated protein deubiquitination (GO:0035520)4.14085956
7mitotic sister chromatid cohesion (GO:0007064)3.96689280
8negative regulation of DNA-dependent DNA replication (GO:2000104)3.91355139
9histone H2A monoubiquitination (GO:0035518)3.86536297
10nuclear pore complex assembly (GO:0051292)3.82925133
11piRNA metabolic process (GO:0034587)3.75147427
12notochord development (GO:0030903)3.72831215
13replication fork processing (GO:0031297)3.70011679
14negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.66968083
15mitotic metaphase plate congression (GO:0007080)3.60545405
16DNA damage response, signal transduction resulting in transcription (GO:0042772)3.60424193
17thrombin receptor signaling pathway (GO:0070493)3.59089893
18regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.54594826
19positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.53839393
20intestinal epithelial cell development (GO:0060576)3.51837463
21protein prenylation (GO:0018342)3.47771854
22prenylation (GO:0097354)3.47771854
23regulation of transforming growth factor beta2 production (GO:0032909)3.45090033
24gene silencing by RNA (GO:0031047)3.44343630
25nuclear pore organization (GO:0006999)3.42158114
26regulation of hippo signaling (GO:0035330)3.41664764
27negative regulation of hormone metabolic process (GO:0032351)3.41453224
28negative regulation of hormone biosynthetic process (GO:0032353)3.41453224
29microtubule depolymerization (GO:0007019)3.37455251
30synapsis (GO:0007129)3.35632125
31embryonic retina morphogenesis in camera-type eye (GO:0060059)3.33250212
32mitotic chromosome condensation (GO:0007076)3.32077586
33DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.30741079
34hemidesmosome assembly (GO:0031581)3.30202362
35negative regulation of histone methylation (GO:0031061)3.24801504
36regulation of telomere maintenance via telomerase (GO:0032210)3.24714219
37lactate metabolic process (GO:0006089)3.24386320
38response to pheromone (GO:0019236)3.23922757
39regulation of posttranscriptional gene silencing (GO:0060147)3.22000838
40regulation of gene silencing by miRNA (GO:0060964)3.22000838
41regulation of gene silencing by RNA (GO:0060966)3.22000838
42positive regulation of mitotic sister chromatid separation (GO:1901970)3.20270563
43positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.20270563
44positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.20270563
45DNA damage induced protein phosphorylation (GO:0006975)3.19334059
46regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.19258527
47mitotic nuclear envelope disassembly (GO:0007077)3.13558558
48DNA catabolic process, exonucleolytic (GO:0000738)3.11717992
49metaphase plate congression (GO:0051310)3.09726767
50epithelial cilium movement (GO:0003351)3.09021253
51regulation of DNA endoreduplication (GO:0032875)3.08867901
52female gamete generation (GO:0007292)3.07781985
53male meiosis (GO:0007140)3.07714153
54membrane disassembly (GO:0030397)3.07277901
55nuclear envelope disassembly (GO:0051081)3.07277901
56cullin deneddylation (GO:0010388)3.06861385
57chromatin remodeling at centromere (GO:0031055)3.04757444
58positive regulation of chromosome segregation (GO:0051984)3.04592714
59centriole replication (GO:0007099)3.02100948
60sister chromatid segregation (GO:0000819)3.00901393
61NLS-bearing protein import into nucleus (GO:0006607)3.00762714
62epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.00672223
63mitotic sister chromatid segregation (GO:0000070)3.00549622
64protein localization to chromosome, centromeric region (GO:0071459)2.98099603
65intraciliary transport (GO:0042073)2.97836569
66regulation of spindle organization (GO:0090224)2.96829193
67histone exchange (GO:0043486)2.96194246
68retinal cone cell development (GO:0046549)2.94412421
69recombinational repair (GO:0000725)2.93985902
70regulation of meiosis I (GO:0060631)2.93521214
71negative regulation of circadian rhythm (GO:0042754)2.93326648
72attachment of spindle microtubules to kinetochore (GO:0008608)2.93090578
73double-strand break repair via homologous recombination (GO:0000724)2.92824154
74regulation of RNA export from nucleus (GO:0046831)2.91963593
75respiratory chain complex IV assembly (GO:0008535)2.91706153
76protein localization to chromosome (GO:0034502)2.89608237
77CENP-A containing nucleosome assembly (GO:0034080)2.88029541
78limb bud formation (GO:0060174)2.84569679
79regulation of mitotic spindle organization (GO:0060236)2.83689274
80double-strand break repair via nonhomologous end joining (GO:0006303)2.82252733
81non-recombinational repair (GO:0000726)2.82252733
82detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.81814606
83photoreceptor cell maintenance (GO:0045494)2.81345879
84hippo signaling (GO:0035329)2.80966174
85somatic hypermutation of immunoglobulin genes (GO:0016446)2.79676283
86somatic diversification of immune receptors via somatic mutation (GO:0002566)2.79676283
87gene silencing (GO:0016458)2.79267177
88platelet dense granule organization (GO:0060155)2.77719708
89protein localization to kinetochore (GO:0034501)2.77670458
90cilium movement (GO:0003341)2.76852782
91adenosine metabolic process (GO:0046085)2.76448321
92protein deneddylation (GO:0000338)2.75471802
93synaptonemal complex assembly (GO:0007130)2.75314715
94maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.75091634
95resolution of meiotic recombination intermediates (GO:0000712)2.74982310
96cilium organization (GO:0044782)2.74729067
97histone lysine demethylation (GO:0070076)2.74505909
98histone H2A acetylation (GO:0043968)2.73755428
99negative regulation of heart rate (GO:0010459)2.73678735
100axoneme assembly (GO:0035082)2.73273154
101histone H2A ubiquitination (GO:0033522)2.73112865
102establishment of chromosome localization (GO:0051303)2.72281711
103cytoplasmic mRNA processing body assembly (GO:0033962)2.70704646
104dopamine transport (GO:0015872)2.70260418
105regulation of chromosome segregation (GO:0051983)2.69537809
106N-terminal protein amino acid acetylation (GO:0006474)2.68258773
107cytochrome complex assembly (GO:0017004)2.68016195
108regulation of translation, ncRNA-mediated (GO:0045974)2.67860078
109negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.67860078
110negative regulation of translation, ncRNA-mediated (GO:0040033)2.67860078
111cilium assembly (GO:0042384)2.67441467
112negative regulation of DNA recombination (GO:0045910)2.66441567
113presynaptic membrane assembly (GO:0097105)2.63781110
114microtubule polymerization or depolymerization (GO:0031109)2.62917577
115regulation of cilium movement (GO:0003352)2.59552220
116oogenesis (GO:0048477)2.59457163
117neurotransmitter uptake (GO:0001504)2.59453683
118mitochondrial DNA replication (GO:0006264)2.58873511
119long-chain fatty acid biosynthetic process (GO:0042759)2.58856437
120meiotic chromosome segregation (GO:0045132)2.57012476
121histone demethylation (GO:0016577)2.56811986
122negative regulation of transcription regulatory region DNA binding (GO:2000678)2.55396424
123pore complex assembly (GO:0046931)2.54190916
124regulation of exit from mitosis (GO:0007096)2.53971635
125mismatch repair (GO:0006298)2.53657298
126intracellular estrogen receptor signaling pathway (GO:0030520)2.53573021
127regulation of retinoic acid receptor signaling pathway (GO:0048385)2.53212174
128fatty acid elongation (GO:0030497)2.52832442
129regulation of meiosis (GO:0040020)2.52243810
130interkinetic nuclear migration (GO:0022027)2.50736663
131protein localization to cilium (GO:0061512)2.50510094
132positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.50165820
133regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.50165820
134meiotic cell cycle (GO:0051321)2.49201785
135ovulation cycle (GO:0042698)2.48845578
136L-fucose metabolic process (GO:0042354)2.48753710
137L-fucose catabolic process (GO:0042355)2.48753710
138fucose catabolic process (GO:0019317)2.48753710
139nuclear envelope organization (GO:0006998)2.46601962
140regulation of centriole replication (GO:0046599)2.45672824
141single strand break repair (GO:0000012)2.45260920
142sister chromatid cohesion (GO:0007062)2.45252525
143inner cell mass cell proliferation (GO:0001833)2.45153454
144positive regulation of p38MAPK cascade (GO:1900745)2.44625009
145negative regulation of neurotransmitter transport (GO:0051589)2.43817909
146detection of light stimulus involved in sensory perception (GO:0050962)2.43564589
147detection of light stimulus involved in visual perception (GO:0050908)2.43564589
148histone H3-K4 methylation (GO:0051568)2.42498576
149neural tube formation (GO:0001841)2.42074701
150negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.41305488
151glucocorticoid receptor signaling pathway (GO:0042921)2.41160027
152columnar/cuboidal epithelial cell development (GO:0002066)2.40791007
153synaptonemal complex organization (GO:0070193)2.40732677
154histone mRNA catabolic process (GO:0071044)2.40252974
155histone H4-K12 acetylation (GO:0043983)2.40152838
156cilium morphogenesis (GO:0060271)2.38971613
157protein dealkylation (GO:0008214)2.38948727
158protein demethylation (GO:0006482)2.38948727
159regulation of glucocorticoid metabolic process (GO:0031943)2.38814410
160reciprocal meiotic recombination (GO:0007131)2.38764591
161reciprocal DNA recombination (GO:0035825)2.38764591
162microtubule anchoring (GO:0034453)2.38733739
163female gonad development (GO:0008585)2.38353141
164DNA replication-dependent nucleosome assembly (GO:0006335)2.37880796
165DNA replication-dependent nucleosome organization (GO:0034723)2.37880796
166negative regulation of smooth muscle cell differentiation (GO:0051151)2.37525965
167double-strand break repair (GO:0006302)2.37319873
168somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.36748712
169somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.36748712
170isotype switching (GO:0045190)2.36748712
171retinal rod cell development (GO:0046548)2.34951717
172regulation of sulfur metabolic process (GO:0042762)2.33900354
173otic vesicle formation (GO:0030916)2.33790162
174folic acid-containing compound biosynthetic process (GO:0009396)2.33706648
175regulation of protein glycosylation (GO:0060049)2.33599405
176anterior/posterior axis specification, embryo (GO:0008595)2.33412448
177kinetochore assembly (GO:0051382)2.33134353
178RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.33109127
179presynaptic membrane organization (GO:0097090)2.32858434
180protein K6-linked ubiquitination (GO:0085020)2.32835932
181regulation of Golgi to plasma membrane protein transport (GO:0042996)2.32655444
182regulation of non-canonical Wnt signaling pathway (GO:2000050)2.32459314
183protein K11-linked deubiquitination (GO:0035871)2.32226329
184kidney morphogenesis (GO:0060993)2.32153813
185maturation of 5.8S rRNA (GO:0000460)2.32060373
186DNA ligation (GO:0006266)2.32001581
187regulation of acyl-CoA biosynthetic process (GO:0050812)2.31240634
188regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.29897962
189negative regulation of meiosis (GO:0045835)2.29428623
190histone H3-K36 demethylation (GO:0070544)2.29256919
191negative regulation of thymocyte apoptotic process (GO:0070244)2.29255059
192positive regulation of mRNA 3-end processing (GO:0031442)2.28930519
193regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.28720616

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.85320188
2SALL1_21062744_ChIP-ChIP_HESCs_Human4.01607507
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.73023512
4GBX2_23144817_ChIP-Seq_PC3_Human3.38525991
5E2F7_22180533_ChIP-Seq_HELA_Human3.35092002
6SMAD3_22036565_ChIP-Seq_ESCs_Mouse3.08718693
7NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.02556639
8* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.99229265
9TAF15_26573619_Chip-Seq_HEK293_Human2.76291466
10IGF1R_20145208_ChIP-Seq_DFB_Human2.76262423
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.67116469
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.64821348
13ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.64003843
14EWS_26573619_Chip-Seq_HEK293_Human2.56685233
15FUS_26573619_Chip-Seq_HEK293_Human2.52273379
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.51328576
17VDR_22108803_ChIP-Seq_LS180_Human2.50837312
18ZNF274_21170338_ChIP-Seq_K562_Hela2.50836857
19AR_21909140_ChIP-Seq_LNCAP_Human2.47027735
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.46677735
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.43308030
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.41456138
23FLI1_27457419_Chip-Seq_LIVER_Mouse2.35452250
24P300_19829295_ChIP-Seq_ESCs_Human2.34293143
25SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.33747482
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.31748794
27EGR1_19374776_ChIP-ChIP_THP-1_Human2.28733308
28* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.11139203
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.06141365
30KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.01717739
31KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.97311865
32KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.97311865
33KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.97311865
34NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.97294792
35TCF3_18692474_ChIP-Seq_MESCs_Mouse1.97175262
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.96907702
37TP63_19390658_ChIP-ChIP_HaCaT_Human1.93549747
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.89503398
39KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.86480310
40SMAD4_21799915_ChIP-Seq_A2780_Human1.83369917
41TCF3_18692474_ChIP-Seq_MEFs_Mouse1.80058141
42HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.78620131
43MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.76572837
44POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.75125000
45MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.73995689
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.73794097
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70583941
48SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.69746537
49ER_23166858_ChIP-Seq_MCF-7_Human1.67661533
50UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.65536891
51ESR1_21235772_ChIP-Seq_MCF-7_Human1.65431957
52ESR2_21235772_ChIP-Seq_MCF-7_Human1.65018504
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.64489393
54EZH2_27294783_Chip-Seq_NPCs_Mouse1.63829079
55GATA1_26923725_Chip-Seq_HPCs_Mouse1.63166229
56SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.62483260
57POU5F1_16153702_ChIP-ChIP_HESCs_Human1.61828741
58ELK1_19687146_ChIP-ChIP_HELA_Human1.60813693
59ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.60068593
60TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.59000596
61SUZ12_27294783_Chip-Seq_NPCs_Mouse1.58340002
62BCAT_22108803_ChIP-Seq_LS180_Human1.58290193
63FOXO3_23340844_ChIP-Seq_DLD1_Human1.56939958
64BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.56902852
65* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56728627
66PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50029914
67STAT3_23295773_ChIP-Seq_U87_Human1.49032730
68TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.48881565
69NANOG_21062744_ChIP-ChIP_HESCs_Human1.48154239
70TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47949678
71NANOG_18555785_Chip-Seq_ESCs_Mouse1.47383663
72* ISL1_27105846_Chip-Seq_CPCs_Mouse1.47229115
73OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46758557
74* AR_25329375_ChIP-Seq_VCAP_Human1.45698291
75EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.45100588
76FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.44809581
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.42284674
78TCF4_18268006_ChIP-ChIP_LS174T_Human1.41972632
79EST1_17652178_ChIP-ChIP_JURKAT_Human1.41945910
80TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.41725365
81NANOG_19829295_ChIP-Seq_ESCs_Human1.41652799
82SOX2_19829295_ChIP-Seq_ESCs_Human1.41652799
83* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.40928581
84POU5F1_16518401_ChIP-PET_MESCs_Mouse1.40740461
85* TCF4_23295773_ChIP-Seq_U87_Human1.40420813
86SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40284331
87P53_22387025_ChIP-Seq_ESCs_Mouse1.38750576
88HTT_18923047_ChIP-ChIP_STHdh_Human1.38035112
89E2F4_17652178_ChIP-ChIP_JURKAT_Human1.37274604
90SMAD3_21741376_ChIP-Seq_EPCs_Human1.36465607
91TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.35323625
92* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.34520173
93RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34386048
94NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.34349572
95PKCTHETA_26484144_Chip-Seq_BREAST_Human1.33841004
96EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.32520266
97NANOG_18692474_ChIP-Seq_MESCs_Mouse1.32149974
98TCF4_22108803_ChIP-Seq_LS180_Human1.32028622
99CBP_20019798_ChIP-Seq_JUKART_Human1.31747976
100IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31747976
101ZFP281_27345836_Chip-Seq_ESCs_Mouse1.31716404
102* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.31378439
103HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.31149310
104E2F1_18555785_Chip-Seq_ESCs_Mouse1.30322368
105SALL4_18804426_ChIP-ChIP_XEN_Mouse1.27426766
106* GATA6_25053715_ChIP-Seq_YYC3_Human1.27365717
107MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27020246
108SUZ12_18555785_Chip-Seq_ESCs_Mouse1.25004742
109PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24884193
110* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.24382684
111EZH2_22144423_ChIP-Seq_EOC_Human1.22778354
112CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.22678467
113ESR1_20079471_ChIP-ChIP_T-47D_Human1.22339609
114PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.22283998
115EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21019786
116POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.20849029
117TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20679909
118NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20267452
119CRX_20693478_ChIP-Seq_RETINA_Mouse1.19592612
120SOX9_24532713_ChIP-Seq_HFSC_Mouse1.19099651
121CMYC_18555785_Chip-Seq_ESCs_Mouse1.17777272
122IRF1_19129219_ChIP-ChIP_H3396_Human1.17135513
123TBX3_20139965_ChIP-Seq_ESCs_Mouse1.17057746
124P300_18555785_Chip-Seq_ESCs_Mouse1.16320431
125CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16260995
126DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.15853125
127MYC_18940864_ChIP-ChIP_HL60_Human1.15361510
128TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15228817
129POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15228817
130STAT3_18555785_Chip-Seq_ESCs_Mouse1.15182404
131TBX3_20139965_ChIP-Seq_MESCs_Mouse1.14368762
132ZNF263_19887448_ChIP-Seq_K562_Human1.13997722
133NANOG_18555785_ChIP-Seq_MESCs_Mouse1.13327260
134GABP_17652178_ChIP-ChIP_JURKAT_Human1.13059986
135PHF8_20622853_ChIP-Seq_HELA_Human1.12444458
136RUNX2_22187159_ChIP-Seq_PCA_Human1.11662654
137KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11549684
138EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.10912178
139RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.10313786
140E2F1_21310950_ChIP-Seq_MCF-7_Human1.10287083
141ZFP281_18757296_ChIP-ChIP_E14_Mouse1.09978385
142EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.09280650
143GATA1_22025678_ChIP-Seq_K562_Human1.09146569
144STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08650742
145NFYB_21822215_ChIP-Seq_K562_Human1.08278524
146ETV1_20927104_ChIP-Seq_GIST48_Human1.08262317
147RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07913656
148FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07296807
149* KDM2B_26808549_Chip-Seq_K562_Human1.06920879
150SOX2_18692474_ChIP-Seq_MESCs_Mouse1.06705267
151RBPJ_21746931_ChIP-Seq_IB4_Human1.06685771
152PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06364176
153* ATF3_27146783_Chip-Seq_COLON_Human1.06314947
154PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.06210092
155FOXA2_19822575_ChIP-Seq_HepG2_Human1.05468951
156OCT4_21477851_ChIP-Seq_ESCs_Mouse1.05368780
157NFYA_21822215_ChIP-Seq_K562_Human1.04370991
158OCT4_18555785_Chip-Seq_ESCs_Mouse1.04095086
159* TAL1_26923725_Chip-Seq_HPCs_Mouse1.03696450
160SOX2_18555785_Chip-Seq_ESCs_Mouse1.03677077
161RBPJ_22232070_ChIP-Seq_NCS_Mouse1.03427994
162RUNX1_26923725_Chip-Seq_HPCs_Mouse1.02807758
163FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02580960
164FOXA1_25329375_ChIP-Seq_VCAP_Human1.02580960
165ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.01171108
166HIF1A_21447827_ChIP-Seq_MCF-7_Human0.99517297
167SOX2_18555785_ChIP-Seq_MESCs_Mouse0.98921636
168FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.98542153
169FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.98435616
170* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.98381889
171* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.98285133
172KAP1_27257070_Chip-Seq_ESCs_Mouse0.97935956
173* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97199176
174STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.95963663
175ELK4_26923725_Chip-Seq_MESODERM_Mouse0.95823554
176NANOG_16518401_ChIP-PET_MESCs_Mouse0.94622686
177SOX2_27498859_Chip-Seq_STOMACH_Mouse0.94621927
178ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94464984
179TBL1_22424771_ChIP-Seq_293T_Human0.93525962
180RUNX1_27514584_Chip-Seq_MCF-7_Human0.92736486
181CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.92654365
182CDX2_22108803_ChIP-Seq_LS180_Human0.91938001
183KLF4_18555785_ChIP-Seq_MESCs_Mouse0.88507596
184* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.87101533
185WT1_25993318_ChIP-Seq_PODOCYTE_Human0.85733624
186NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.85209115
187NANOG_18692474_ChIP-Seq_MEFs_Mouse0.85104974
188NFIB_24661679_ChIP-Seq_LUNG_Mouse0.84907324
189MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.84423925
190* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.83784921

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology4.41454579
2MP0002102_abnormal_ear_morphology3.18268084
3MP0001849_ear_inflammation2.85342761
4MP0005646_abnormal_pituitary_gland2.74861130
5MP0003693_abnormal_embryo_hatching2.74767233
6MP0010030_abnormal_orbit_morphology2.62806467
7MP0008058_abnormal_DNA_repair2.60601245
8MP0005464_abnormal_platelet_physiology2.58294333
9MP0002254_reproductive_system_inflammat2.56781195
10MP0004264_abnormal_extraembryonic_tissu2.52628468
11MP0003111_abnormal_nucleus_morphology2.47350920
12MP0002736_abnormal_nociception_after2.39347914
13MP0000579_abnormal_nail_morphology2.36399133
14MP0009697_abnormal_copulation2.34185819
15MP0003646_muscle_fatigue2.28529840
16MP0005076_abnormal_cell_differentiation2.23309972
17MP0004185_abnormal_adipocyte_glucose2.16372108
18MP0005551_abnormal_eye_electrophysiolog2.03978771
19MP0006072_abnormal_retinal_apoptosis2.02753337
20MP0005253_abnormal_eye_physiology1.97177157
21MP0004957_abnormal_blastocyst_morpholog1.96843471
22MP0010094_abnormal_chromosome_stability1.96218651
23MP0006276_abnormal_autonomic_nervous1.94838497
24MP0003705_abnormal_hypodermis_morpholog1.94390161
25MP0000383_abnormal_hair_follicle1.93951852
26MP0004233_abnormal_muscle_weight1.91580656
27MP0003077_abnormal_cell_cycle1.90992682
28MP0006054_spinal_hemorrhage1.79513744
29MP0010678_abnormal_skin_adnexa1.77518796
30MP0003123_paternal_imprinting1.75499307
31MP0002938_white_spotting1.73928488
32MP0003937_abnormal_limbs/digits/tail_de1.73840189
33MP0008877_abnormal_DNA_methylation1.73753151
34MP0000462_abnormal_digestive_system1.72375060
35MP0001968_abnormal_touch/_nociception1.67666243
36MP0008872_abnormal_physiological_respon1.63379370
37MP0004215_abnormal_myocardial_fiber1.61518948
38MP0000566_synostosis1.61406745
39MP0003718_maternal_effect1.60389529
40MP0004147_increased_porphyrin_level1.59764384
41MP0002085_abnormal_embryonic_tissue1.59149401
42MP0002084_abnormal_developmental_patter1.59056965
43MP0001730_embryonic_growth_arrest1.57280378
44MP0003880_abnormal_central_pattern1.50065914
45MP0003121_genomic_imprinting1.48335905
46MP0005084_abnormal_gallbladder_morpholo1.46746258
47MP0003890_abnormal_embryonic-extraembry1.44463543
48MP0000350_abnormal_cell_proliferation1.44200435
49MP0000647_abnormal_sebaceous_gland1.42627279
50MP0002877_abnormal_melanocyte_morpholog1.41941763
51MP0001486_abnormal_startle_reflex1.41173623
52MP0003453_abnormal_keratinocyte_physiol1.40565255
53MP0000733_abnormal_muscle_development1.39632381
54MP0008775_abnormal_heart_ventricle1.39291408
55MP0001672_abnormal_embryogenesis/_devel1.38505307
56MP0005380_embryogenesis_phenotype1.38505307
57MP0000427_abnormal_hair_cycle1.36116729
58MP0000631_abnormal_neuroendocrine_gland1.35542565
59MP0010234_abnormal_vibrissa_follicle1.33537943
60MP0006292_abnormal_olfactory_placode1.33523269
61MP0002249_abnormal_larynx_morphology1.33270068
62MP0001346_abnormal_lacrimal_gland1.32608751
63MP0010307_abnormal_tumor_latency1.31813591
64MP0001529_abnormal_vocalization1.29263933
65MP0001485_abnormal_pinna_reflex1.27966049
66MP0008789_abnormal_olfactory_epithelium1.27735895
67MP0003787_abnormal_imprinting1.27297699
68MP0010352_gastrointestinal_tract_polyps1.26827141
69MP0001697_abnormal_embryo_size1.26704915
70MP0005451_abnormal_body_composition1.26522312
71MP0002086_abnormal_extraembryonic_tissu1.25598180
72MP0001915_intracranial_hemorrhage1.22910471
73MP0003566_abnormal_cell_adhesion1.22693793
74MP0001984_abnormal_olfaction1.22559112
75MP0003984_embryonic_growth_retardation1.21491521
76MP0008004_abnormal_stomach_pH1.21372421
77MP0002234_abnormal_pharynx_morphology1.20734417
78MP0003699_abnormal_female_reproductive1.19871470
79MP0002088_abnormal_embryonic_growth/wei1.19082154
80MP0000230_abnormal_systemic_arterial1.18670862
81MP0000372_irregular_coat_pigmentation1.18230402
82MP0001929_abnormal_gametogenesis1.18143364
83MP0003122_maternal_imprinting1.17256652
84MP0005410_abnormal_fertilization1.16752837
85MP0003195_calcinosis1.15713940
86MP0000432_abnormal_head_morphology1.14370023
87MP0009046_muscle_twitch1.13237120
88MP0003252_abnormal_bile_duct1.13210512
89MP0001286_abnormal_eye_development1.12568256
90MP0002697_abnormal_eye_size1.10585073
91MP0000534_abnormal_ureter_morphology1.10483171
92MP0005248_abnormal_Harderian_gland1.10439103
93MP0003011_delayed_dark_adaptation1.10427717
94MP0008007_abnormal_cellular_replicative1.09895274
95MP0004885_abnormal_endolymph1.09877323
96MP0002269_muscular_atrophy1.09554600
97MP0004197_abnormal_fetal_growth/weight/1.09307812
98MP0001188_hyperpigmentation1.08594148
99MP0005167_abnormal_blood-brain_barrier1.08589742
100MP0004145_abnormal_muscle_electrophysio1.07442224
101MP0009053_abnormal_anal_canal1.06593267
102MP0003941_abnormal_skin_development1.06565101
103MP0001293_anophthalmia1.06179260
104MP0004084_abnormal_cardiac_muscle1.05892057
105MP0002210_abnormal_sex_determination1.03183607
106MP0002751_abnormal_autonomic_nervous1.02923482
107MP0000653_abnormal_sex_gland1.02110073
108MP0000516_abnormal_urinary_system1.01678638
109MP0005367_renal/urinary_system_phenotyp1.01678638
110MP0000569_abnormal_digit_pigmentation0.99676018
111MP0005666_abnormal_adipose_tissue0.99241022
112MP0000537_abnormal_urethra_morphology0.99215203
113MP0003755_abnormal_palate_morphology0.99152051
114MP0003283_abnormal_digestive_organ0.98625057
115MP0008932_abnormal_embryonic_tissue0.97631526
116MP0005499_abnormal_olfactory_system0.97421851
117MP0005394_taste/olfaction_phenotype0.97421851
118MP0001119_abnormal_female_reproductive0.96999185
119MP0002092_abnormal_eye_morphology0.95931462
120MP0002098_abnormal_vibrissa_morphology0.95908565
121MP0003698_abnormal_male_reproductive0.95820435
122MP0002282_abnormal_trachea_morphology0.95650597
123MP0002733_abnormal_thermal_nociception0.95180625
124MP0003861_abnormal_nervous_system0.95144289
125MP0002638_abnormal_pupillary_reflex0.94505071
126MP0005083_abnormal_biliary_tract0.93347610
127MP0005257_abnormal_intraocular_pressure0.93268613
128MP0005391_vision/eye_phenotype0.93214760
129MP0003656_abnormal_erythrocyte_physiolo0.93136218
130MP0004142_abnormal_muscle_tone0.92692602
131MP0003935_abnormal_craniofacial_develop0.91618673
132MP0002233_abnormal_nose_morphology0.91580176
133MP0000465_gastrointestinal_hemorrhage0.91484561
134MP0008961_abnormal_basal_metabolism0.90953759
135MP0009780_abnormal_chondrocyte_physiolo0.90705419
136MP0005187_abnormal_penis_morphology0.90195261
137MP0002932_abnormal_joint_morphology0.89996057
138MP0005647_abnormal_sex_gland0.89755445
139MP0003786_premature_aging0.89167059
140MP0006036_abnormal_mitochondrial_physio0.89122893
141MP0003300_gastrointestinal_ulcer0.89102209
142MP0002116_abnormal_craniofacial_bone0.88691532
143MP0008057_abnormal_DNA_replication0.88501226
144MP0002138_abnormal_hepatobiliary_system0.86776579
145MP0003119_abnormal_digestive_system0.86543521
146MP0002837_dystrophic_cardiac_calcinosis0.86239823
147MP0001661_extended_life_span0.86145556
148MP0005195_abnormal_posterior_eye0.85579457
149MP0003115_abnormal_respiratory_system0.85145070
150MP0005395_other_phenotype0.85026177
151MP0001299_abnormal_eye_distance/0.84261790
152MP0009745_abnormal_behavioral_response0.83815279
153MP0002080_prenatal_lethality0.83786651
154MP0001970_abnormal_pain_threshold0.83682571
155MP0001145_abnormal_male_reproductive0.82922887
156MP0009672_abnormal_birth_weight0.82428166
157MP0004133_heterotaxia0.82125265
158MP0002272_abnormal_nervous_system0.82050847
159MP0005023_abnormal_wound_healing0.81009057
160MP0001324_abnormal_eye_pigmentation0.79954529
161MP0004085_abnormal_heartbeat0.77933614
162MP0002735_abnormal_chemical_nociception0.77084832
163MP0005174_abnormal_tail_pigmentation0.76510052
164MP0006035_abnormal_mitochondrial_morpho0.75993802
165MP0005389_reproductive_system_phenotype0.74765377
166MP0002160_abnormal_reproductive_system0.74327706

Predicted human phenotypes

RankGene SetZ-score
1True hermaphroditism (HP:0010459)3.83524715
2Pancreatic fibrosis (HP:0100732)3.64748071
3Pancreatic cysts (HP:0001737)3.61035913
4Shawl scrotum (HP:0000049)3.55536303
5Papillary thyroid carcinoma (HP:0002895)3.33396511
6Abnormality of the labia minora (HP:0012880)3.23654651
7Prolonged bleeding time (HP:0003010)3.08630961
8Increased mean platelet volume (HP:0011877)3.06738784
9Ependymoma (HP:0002888)3.03892303
10Petechiae (HP:0000967)2.81249537
11Astrocytoma (HP:0009592)2.81014584
12Abnormality of the astrocytes (HP:0100707)2.81014584
13Heterotopia (HP:0002282)2.80109784
14Lip pit (HP:0100267)2.77339578
15Molar tooth sign on MRI (HP:0002419)2.76957127
16Abnormality of midbrain morphology (HP:0002418)2.76957127
17Nephronophthisis (HP:0000090)2.72483586
18Abnormality of the fingertips (HP:0001211)2.71839537
19Colon cancer (HP:0003003)2.70527736
20Cortical dysplasia (HP:0002539)2.66263276
21Facial hemangioma (HP:0000329)2.61321686
22Abnormal platelet volume (HP:0011876)2.58005926
23Decreased central vision (HP:0007663)2.54618091
24Menorrhagia (HP:0000132)2.52765256
25Anal stenosis (HP:0002025)2.51722647
26Intestinal atresia (HP:0011100)2.51001949
27Impulsivity (HP:0100710)2.49941806
28Oligodactyly (HP:0012165)2.45564168
29Abolished electroretinogram (ERG) (HP:0000550)2.45094107
30Aplasia/Hypoplasia of the tongue (HP:0010295)2.43117281
31Medial flaring of the eyebrow (HP:0010747)2.42109014
32Abnormality of the renal medulla (HP:0100957)2.40971286
33Oligodactyly (hands) (HP:0001180)2.38324811
34Neoplasm of the oral cavity (HP:0100649)2.38150989
35Dyschromatopsia (HP:0007641)2.35559220
36Milia (HP:0001056)2.35348979
37Aplasia/Hypoplasia of the uvula (HP:0010293)2.34025477
38Cystic liver disease (HP:0006706)2.32438927
39Abnormality of the renal cortex (HP:0011035)2.31026561
40Abnormality of chromosome stability (HP:0003220)2.30662255
41Hyperglycinuria (HP:0003108)2.30067366
42Rib fusion (HP:0000902)2.28992201
43Male infertility (HP:0003251)2.28376481
44Hypoplastic labia majora (HP:0000059)2.27782521
45Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.26901767
46Glioma (HP:0009733)2.26390657
47Chronic hepatic failure (HP:0100626)2.25800036
48Neoplasm of striated muscle (HP:0009728)2.25140604
49Chromosomal breakage induced by crosslinking agents (HP:0003221)2.23986151
50Esophageal atresia (HP:0002032)2.22568843
51Abnormality of the labia majora (HP:0012881)2.20112966
52Abnormal ciliary motility (HP:0012262)2.17736483
53Furrowed tongue (HP:0000221)2.16948436
54Trigonocephaly (HP:0000243)2.14756920
55Pili torti (HP:0003777)2.13737099
56Patellar aplasia (HP:0006443)2.13021735
57Rhabdomyosarcoma (HP:0002859)2.12934321
58Medulloblastoma (HP:0002885)2.11469398
59Chromsome breakage (HP:0040012)2.06652518
60Hypothermia (HP:0002045)2.05759549
61Breast hypoplasia (HP:0003187)2.05438306
62Attenuation of retinal blood vessels (HP:0007843)2.04747573
63Focal segmental glomerulosclerosis (HP:0000097)2.04035325
64Congenital hepatic fibrosis (HP:0002612)2.02509001
65Hypoplastic ischia (HP:0003175)2.02274708
66Hyperglycinemia (HP:0002154)2.02207429
67Hemiparesis (HP:0001269)2.02048300
68Anterior segment dysgenesis (HP:0007700)2.02018608
69Abnormality of chromosome segregation (HP:0002916)1.99875731
70Anencephaly (HP:0002323)1.98991841
71Meckel diverticulum (HP:0002245)1.98168624
72Aplasia/Hypoplasia of the sternum (HP:0006714)1.97192106
73Supernumerary spleens (HP:0009799)1.96496531
74Bicornuate uterus (HP:0000813)1.96317847
75Genital tract atresia (HP:0001827)1.95281459
76Long eyelashes (HP:0000527)1.95094382
77Abnormality of the ileum (HP:0001549)1.94876926
78Abnormality of the preputium (HP:0100587)1.94109625
79Congenital stationary night blindness (HP:0007642)1.93958120
80Abnormality of macular pigmentation (HP:0008002)1.92798798
81Broad thumb (HP:0011304)1.92459362
82Abnormal respiratory motile cilium physiology (HP:0012261)1.92420914
83Abnormal biliary tract physiology (HP:0012439)1.92390297
84Bile duct proliferation (HP:0001408)1.92390297
85Sandal gap (HP:0001852)1.92290138
86Hemivertebrae (HP:0002937)1.92121268
87Poikilocytosis (HP:0004447)1.92070253
88Central scotoma (HP:0000603)1.91916414
89Midline defect of the nose (HP:0004122)1.91740393
90Postaxial foot polydactyly (HP:0001830)1.91222143
91Acute encephalopathy (HP:0006846)1.91150561
92Preaxial hand polydactyly (HP:0001177)1.91029246
93Dynein arm defect of respiratory motile cilia (HP:0012255)1.90339239
94Absent/shortened dynein arms (HP:0200106)1.90339239
95Clubbing of toes (HP:0100760)1.89967961
96Malignant gastrointestinal tract tumors (HP:0006749)1.89902981
97Gastrointestinal carcinoma (HP:0002672)1.89902981
98Widely spaced teeth (HP:0000687)1.88874814
99Growth hormone deficiency (HP:0000824)1.88205083
100Abnormality of the labia (HP:0000058)1.87938500
101Abnormal lung lobation (HP:0002101)1.87900354
102Pancreatic islet-cell hyperplasia (HP:0004510)1.87548940
103Aplasia/Hypoplasia of the patella (HP:0006498)1.86995569
104Abnormality of the duodenum (HP:0002246)1.86567920
105Small intestinal stenosis (HP:0012848)1.86390433
106Duodenal stenosis (HP:0100867)1.86390433
107Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.86272009
108Abnormality of glycine metabolism (HP:0010895)1.86157271
109Abnormality of serine family amino acid metabolism (HP:0010894)1.86157271
110Hypoplastic female external genitalia (HP:0012815)1.86040756
111Sloping forehead (HP:0000340)1.86037807
112Male pseudohermaphroditism (HP:0000037)1.85818387
113Chronic bronchitis (HP:0004469)1.85185698
114Aqueductal stenosis (HP:0002410)1.84884270
115Progressive macrocephaly (HP:0004481)1.83976815
116Abnormal respiratory epithelium morphology (HP:0012253)1.83478372
117Abnormal respiratory motile cilium morphology (HP:0005938)1.83478372
118Abnormal drinking behavior (HP:0030082)1.83142388
119Polydipsia (HP:0001959)1.83142388
120Abnormality of the distal phalanx of the thumb (HP:0009617)1.82907016
121Hyperglycemia (HP:0003074)1.82757873
122Acanthocytosis (HP:0001927)1.82626016
123Chorioretinal atrophy (HP:0000533)1.82612062
124Depressed nasal tip (HP:0000437)1.82521686
125Pendular nystagmus (HP:0012043)1.82205027
126Vaginal atresia (HP:0000148)1.82188615
127Aplasia/Hypoplasia of the breasts (HP:0010311)1.81403811
128Abnormality of the ischium (HP:0003174)1.80810507
129Short 4th metacarpal (HP:0010044)1.80305892
130Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.80305892
131Increased nuchal translucency (HP:0010880)1.79717459
132Breast aplasia (HP:0100783)1.79287929
133Ectopic kidney (HP:0000086)1.78968701
134Skull defect (HP:0001362)1.78276877
135Renal cortical cysts (HP:0000803)1.77031426
136Sclerocornea (HP:0000647)1.76336996
137Abnormality of aspartate family amino acid metabolism (HP:0010899)1.76172826
138Hypomagnesemia (HP:0002917)1.76052560
139Abnormality of the pubic bones (HP:0003172)1.75790401
140Postaxial hand polydactyly (HP:0001162)1.75290141
141Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.75142504
142Leiomyosarcoma (HP:0100243)1.74784624
143Uterine leiomyosarcoma (HP:0002891)1.74784624
144Abnormal rod and cone electroretinograms (HP:0008323)1.74643784
145Methylmalonic acidemia (HP:0002912)1.74457921
146Congenital primary aphakia (HP:0007707)1.74083354
147Duplicated collecting system (HP:0000081)1.74009347
148Bony spicule pigmentary retinopathy (HP:0007737)1.73923316
149Gaze-evoked nystagmus (HP:0000640)1.73536328
150Optic nerve hypoplasia (HP:0000609)1.71967964
151Pseudobulbar signs (HP:0002200)1.71176177
152Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.71101209
153Oculomotor apraxia (HP:0000657)1.70955792
154Ulnar deviation of the wrist (HP:0003049)1.70558544
155Muscle fiber inclusion bodies (HP:0100299)1.69011334
156Right ventricular cardiomyopathy (HP:0011663)1.68241216
157Truncal obesity (HP:0001956)1.67065196
158Overlapping toe (HP:0001845)1.66421113
159Transitional cell carcinoma of the bladder (HP:0006740)1.66389441
160Fragile nails (HP:0001808)1.66193068
161Birth length less than 3rd percentile (HP:0003561)1.66104257
162Shallow orbits (HP:0000586)1.64293627
163Tubular atrophy (HP:0000092)1.64172105
164Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.63364017
165Biliary tract neoplasm (HP:0100574)1.63226919
166Mesangial abnormality (HP:0001966)1.63032419
167Selective tooth agenesis (HP:0001592)1.62826711
168Abnormality of the proximal phalanges of the hand (HP:0009834)1.61742739
169Deep palmar crease (HP:0006191)1.58228320
170Bladder carcinoma (HP:0002862)1.58197505
171Bladder neoplasm (HP:0009725)1.58197505
172Broad palm (HP:0001169)1.57040140
173Gastrointestinal atresia (HP:0002589)1.56349381
174Volvulus (HP:0002580)1.55891337
175Urethral obstruction (HP:0000796)1.55760629
176Broad hallux (HP:0010055)1.55161884
177Cystic hygroma (HP:0000476)1.54132801
178Flat acetabular roof (HP:0003180)1.54093679
179Hypoplastic toenails (HP:0001800)1.54010884
180Prominent nose (HP:0000448)1.52813025
181Labial hypoplasia (HP:0000066)1.51532655
182Ulnar deviation of finger (HP:0009465)1.51225171
183Preaxial foot polydactyly (HP:0001841)1.50714956
184Sparse lateral eyebrow (HP:0005338)1.50540110
185Difficulty running (HP:0009046)1.48412606
186Fibular aplasia (HP:0002990)1.48391932
187Aplasia involving bones of the extremities (HP:0009825)1.48258961
188Aplasia of the phalanges of the hand (HP:0009802)1.48258961

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS15.01559249
2CDK123.76925358
3FRK3.74123294
4MST43.15766343
5MKNK22.91487299
6TNIK2.85483378
7STK38L2.80957390
8LATS22.72599143
9ERBB42.64297617
10EEF2K2.46941327
11MAP4K22.45660004
12MKNK12.42334936
13TTK2.38555373
14EIF2AK12.36856971
15ACVR1B2.34846666
16BMPR1B2.28818348
17PLK22.27292445
18WNK32.26598608
19MAP3K62.26034170
20ZAK2.23337104
21PLK42.13669592
22CDC72.12414317
23TRIM282.12196575
24PRKD32.02092664
25BRSK21.97081464
26DMPK1.95775323
27STK101.90204598
28PNCK1.85946377
29STK31.85565055
30TAOK11.80363418
31EIF2AK31.76679436
32NEK21.66755257
33MAP3K91.58696641
34KSR21.54778122
35STK391.53820153
36CAMK1D1.49063643
37OXSR11.45796461
38BUB11.44232885
39MELK1.41480283
40ICK1.40650133
41CHEK21.36864151
42MAPKAPK31.36225414
43EPHA21.35893364
44ERBB31.34257354
45TYRO31.33969577
46MTOR1.33026368
47CDK61.32760435
48KSR11.32306606
49CDK91.29416139
50SIK11.28527678
51FGFR21.28276127
52CAMK1G1.26299314
53NEK11.25864726
54RPS6KB21.24349024
55CASK1.24061569
56ADRBK21.23623351
57EPHB21.19671743
58WEE11.17122366
59GRK11.16123516
60TSSK61.15981615
61MAP3K81.12806882
62TEC1.10787442
63ERBB21.09537598
64CSNK1G11.09471313
65MAPK131.08679035
66NUAK11.05209253
67PINK11.04582952
68VRK11.03383102
69TRIB31.03282699
70PLK11.02086201
71TAF11.01941230
72TGFBR10.99557633
73PBK0.97345219
74BRAF0.95547284
75NTRK20.95474309
76MAP3K100.91216798
77CHEK10.90651278
78BCR0.87194793
79STK160.86643040
80CSNK1G20.86450273
81PTK2B0.86002317
82CSNK1G30.85859522
83INSRR0.84503118
84CDK70.84495119
85SRPK10.82799603
86PRKAA10.81998097
87SGK30.81766047
88STK380.81464779
89MINK10.81023559
90GRK50.80740921
91AKT20.78893565
92CSNK1A1L0.78266343
93CDK40.76619911
94MAPK150.75731276
95TAOK30.75466034
96PRKAA20.73443363
97PAK40.71890139
98PRKCE0.71412899
99BMX0.71397377
100AURKB0.71322157
101SIK30.70352818
102PLK30.69805455
103ATM0.68881178
104CDK30.68474129
105MOS0.68224861
106PTK20.67882048
107MAP3K50.66066718
108EIF2AK20.65092733
109IRAK10.64821010
110CHUK0.63269971
111PTK60.62765952
112MAP3K130.62524947
113OBSCN0.61551197
114BRD40.61490390
115PKN10.61195209
116MAPK110.60964505
117RET0.60959184
118SGK20.60895065
119ATR0.60515148
120RAF10.58974748
121DYRK30.58897986
122PAK30.58561727
123MAP3K70.58485955
124CDC42BPA0.58413846
125NTRK30.57907311
126CDK20.57446107
127PAK60.57425405
128EPHA40.56385589
129STK240.56337485
130CCNB10.54768147
131NLK0.54450272
132PRKCG0.53973396
133PIK3CG0.53094663
134RIPK10.51942722
135CDK10.51938514
136AURKA0.50677074
137RPS6KA10.47665964
138MAP3K40.47593042
139CDK80.46149080
140ERN10.46143185
141WNK40.45968571
142YES10.45884677
143PHKG20.45786325
144PHKG10.45786325
145MET0.45055064
146DYRK20.44998466
147NEK90.44630022
148FLT30.43848298
149MAP3K30.43586286
150MUSK0.43046686
151PDGFRB0.42169476
152DDR20.41804856
153CSNK1D0.41410829
154MAPKAPK50.40803423
155GSK3B0.40236876
156FER0.40159334
157BRSK10.39961757
158AKT30.39378793
159DYRK1B0.39029007
160TTN0.38415147
161MAPK10.37558196
162ALK0.37534891
163ADRBK10.37382409
164MAPK140.37290004
165VRK20.36344398
166CSNK1E0.36300727
167DAPK20.34027186
168PRKG10.33899339
169BMPR20.32984097
170TNK20.32913917
171TIE10.31993265
172CAMK2A0.30199527
173IRAK20.27626818
174FGR0.24791217

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.87134834
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.97599703
3Propanoate metabolism_Homo sapiens_hsa006402.65146511
4Cell cycle_Homo sapiens_hsa041102.50446592
5Circadian rhythm_Homo sapiens_hsa047102.41845983
6Phototransduction_Homo sapiens_hsa047442.32927269
7Homologous recombination_Homo sapiens_hsa034402.28629291
8Caffeine metabolism_Homo sapiens_hsa002322.22651638
9Vitamin B6 metabolism_Homo sapiens_hsa007502.17342966
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.10698763
11Fatty acid elongation_Homo sapiens_hsa000622.07659925
12Adherens junction_Homo sapiens_hsa045202.07020353
13Steroid biosynthesis_Homo sapiens_hsa001002.01125964
14Hippo signaling pathway_Homo sapiens_hsa043902.00165669
15Butanoate metabolism_Homo sapiens_hsa006501.97314846
16Dorso-ventral axis formation_Homo sapiens_hsa043201.92080550
17Protein export_Homo sapiens_hsa030601.90717279
18Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.88248164
19Basal cell carcinoma_Homo sapiens_hsa052171.72315535
20Bladder cancer_Homo sapiens_hsa052191.59178041
21Proteasome_Homo sapiens_hsa030501.58956673
22Lysine degradation_Homo sapiens_hsa003101.56081005
23TGF-beta signaling pathway_Homo sapiens_hsa043501.55122921
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.54645524
25Notch signaling pathway_Homo sapiens_hsa043301.52922585
26MicroRNAs in cancer_Homo sapiens_hsa052061.51570772
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.43229629
28Thyroid hormone signaling pathway_Homo sapiens_hsa049191.42082030
29Hedgehog signaling pathway_Homo sapiens_hsa043401.38887955
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.37314948
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.37228033
32Platelet activation_Homo sapiens_hsa046111.34900742
33p53 signaling pathway_Homo sapiens_hsa041151.34575178
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.33316613
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.32943306
36RNA polymerase_Homo sapiens_hsa030201.32015923
37Endometrial cancer_Homo sapiens_hsa052131.31728423
38Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.30488996
39Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.28328278
40Olfactory transduction_Homo sapiens_hsa047401.26131835
41Primary bile acid biosynthesis_Homo sapiens_hsa001201.25976903
42RNA degradation_Homo sapiens_hsa030181.25959124
43Tight junction_Homo sapiens_hsa045301.24249605
44Arachidonic acid metabolism_Homo sapiens_hsa005901.23429463
45Basal transcription factors_Homo sapiens_hsa030221.21534104
46Pancreatic cancer_Homo sapiens_hsa052121.21120001
47Small cell lung cancer_Homo sapiens_hsa052221.20088764
48RNA transport_Homo sapiens_hsa030131.20030266
49Fatty acid biosynthesis_Homo sapiens_hsa000611.18468488
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18307240
51mTOR signaling pathway_Homo sapiens_hsa041501.17924455
52DNA replication_Homo sapiens_hsa030301.17463083
53beta-Alanine metabolism_Homo sapiens_hsa004101.15371542
54mRNA surveillance pathway_Homo sapiens_hsa030151.14637702
55Chronic myeloid leukemia_Homo sapiens_hsa052201.13937616
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.13389213
57Serotonergic synapse_Homo sapiens_hsa047261.11018114
58Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.09774158
59Purine metabolism_Homo sapiens_hsa002301.07880878
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.06841605
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.06603906
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.05975241
63Linoleic acid metabolism_Homo sapiens_hsa005911.05735440
64Ovarian steroidogenesis_Homo sapiens_hsa049131.04989302
65Oocyte meiosis_Homo sapiens_hsa041141.03777094
66Peroxisome_Homo sapiens_hsa041461.00103839
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00021103
68Glycerolipid metabolism_Homo sapiens_hsa005610.97376578
69Collecting duct acid secretion_Homo sapiens_hsa049660.95073417
70Tryptophan metabolism_Homo sapiens_hsa003800.94827387
71Renal cell carcinoma_Homo sapiens_hsa052110.94727967
72Glutathione metabolism_Homo sapiens_hsa004800.94301220
73Colorectal cancer_Homo sapiens_hsa052100.93620889
74Thyroid cancer_Homo sapiens_hsa052160.93518689
75Wnt signaling pathway_Homo sapiens_hsa043100.92046534
76Oxidative phosphorylation_Homo sapiens_hsa001900.92014123
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91353967
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.91072270
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.90993340
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.88978955
81Parkinsons disease_Homo sapiens_hsa050120.87919444
82Nucleotide excision repair_Homo sapiens_hsa034200.87836612
83Nicotine addiction_Homo sapiens_hsa050330.86903268
84Prostate cancer_Homo sapiens_hsa052150.86744634
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.86395629
86Arginine biosynthesis_Homo sapiens_hsa002200.85624650
87Glucagon signaling pathway_Homo sapiens_hsa049220.85015206
88Choline metabolism in cancer_Homo sapiens_hsa052310.84604180
89Base excision repair_Homo sapiens_hsa034100.83577674
90One carbon pool by folate_Homo sapiens_hsa006700.83368987
91Regulation of autophagy_Homo sapiens_hsa041400.83100023
92FoxO signaling pathway_Homo sapiens_hsa040680.82793414
93Sulfur metabolism_Homo sapiens_hsa009200.82574154
94AMPK signaling pathway_Homo sapiens_hsa041520.82490729
95Circadian entrainment_Homo sapiens_hsa047130.82444773
96Proteoglycans in cancer_Homo sapiens_hsa052050.81497820
97Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.80929459
98Prolactin signaling pathway_Homo sapiens_hsa049170.78741913
99GnRH signaling pathway_Homo sapiens_hsa049120.77224276
100Non-small cell lung cancer_Homo sapiens_hsa052230.76854257
101Bile secretion_Homo sapiens_hsa049760.76259620
102Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74835620
103Long-term depression_Homo sapiens_hsa047300.73448730
104Retinol metabolism_Homo sapiens_hsa008300.72437929
105Insulin resistance_Homo sapiens_hsa049310.72136705
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.72121203
107Taste transduction_Homo sapiens_hsa047420.71534018
108Insulin signaling pathway_Homo sapiens_hsa049100.71299729
109Fatty acid metabolism_Homo sapiens_hsa012120.71041218
110HTLV-I infection_Homo sapiens_hsa051660.69499946
111ErbB signaling pathway_Homo sapiens_hsa040120.69058173
112Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.68365130
113Selenocompound metabolism_Homo sapiens_hsa004500.67583823
114Pathways in cancer_Homo sapiens_hsa052000.67028283
115Cysteine and methionine metabolism_Homo sapiens_hsa002700.64937433
116GABAergic synapse_Homo sapiens_hsa047270.64581762
117VEGF signaling pathway_Homo sapiens_hsa043700.63098582
118Estrogen signaling pathway_Homo sapiens_hsa049150.62437738
119SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61602093
120Metabolic pathways_Homo sapiens_hsa011000.61151770
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60955686
122Biosynthesis of amino acids_Homo sapiens_hsa012300.60196787
123Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59206044
124Glioma_Homo sapiens_hsa052140.58504536
125Fat digestion and absorption_Homo sapiens_hsa049750.58415429
126Viral carcinogenesis_Homo sapiens_hsa052030.57839413
127Pyruvate metabolism_Homo sapiens_hsa006200.57614316
128Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57571474
129Glutamatergic synapse_Homo sapiens_hsa047240.56903923
130Alcoholism_Homo sapiens_hsa050340.56893828
131Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56752550
132Glycerophospholipid metabolism_Homo sapiens_hsa005640.56415954
133Fanconi anemia pathway_Homo sapiens_hsa034600.55774977
134Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54985071
135Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54442134
136Morphine addiction_Homo sapiens_hsa050320.54182159
137Pancreatic secretion_Homo sapiens_hsa049720.53997356
138Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.53841373
139Focal adhesion_Homo sapiens_hsa045100.52529496
140Pyrimidine metabolism_Homo sapiens_hsa002400.52424004
141Vascular smooth muscle contraction_Homo sapiens_hsa042700.52353379
142Arginine and proline metabolism_Homo sapiens_hsa003300.52346901
143Cyanoamino acid metabolism_Homo sapiens_hsa004600.51801044
144ECM-receptor interaction_Homo sapiens_hsa045120.51733829
145Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.51420457
146Ether lipid metabolism_Homo sapiens_hsa005650.50780198
147Salivary secretion_Homo sapiens_hsa049700.49411893
148Huntingtons disease_Homo sapiens_hsa050160.49162994
149Non-homologous end-joining_Homo sapiens_hsa034500.48964541
150Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47943183
151ABC transporters_Homo sapiens_hsa020100.47506089
152Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44270611
153Mineral absorption_Homo sapiens_hsa049780.44260437
154Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44058143
155Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43776676
156Fatty acid degradation_Homo sapiens_hsa000710.43765913
157Melanogenesis_Homo sapiens_hsa049160.43040649
158Neurotrophin signaling pathway_Homo sapiens_hsa047220.42971145
159Melanoma_Homo sapiens_hsa052180.42604844
160Starch and sucrose metabolism_Homo sapiens_hsa005000.41827224
161Maturity onset diabetes of the young_Homo sapiens_hsa049500.40678608
162MAPK signaling pathway_Homo sapiens_hsa040100.40427273
163Mismatch repair_Homo sapiens_hsa034300.40209570
164Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39840328
165Phospholipase D signaling pathway_Homo sapiens_hsa040720.39697528
166Chemical carcinogenesis_Homo sapiens_hsa052040.39473378
167Type II diabetes mellitus_Homo sapiens_hsa049300.39422191
168PPAR signaling pathway_Homo sapiens_hsa033200.39229725
169Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.38671882
170Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36356934

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