STOM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a highly conserved family of integral membrane proteins. The encoded protein localizes to the cell membrane of red blood cells and other cell types, where it may regulate ion channels and transporters. Loss of localization of the encoded protein is associated with hereditary stomatocytosis, a form of hemolytic anemia. There is a pseudogene for this gene on chromosome 6. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sensory perception of smell (GO:0007608)7.37208387
2positive regulation by symbiont of host defense response (GO:0052509)4.36846624
3modulation by symbiont of host defense response (GO:0052031)4.36846624
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.36846624
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.36846624
6positive regulation by organism of defense response of other organism involved in symbiotic interact4.36846624
7modulation by symbiont of host immune response (GO:0052553)4.36846624
8low-density lipoprotein particle clearance (GO:0034383)4.21401792
9sensory perception of chemical stimulus (GO:0007606)3.93388073
10protoporphyrinogen IX metabolic process (GO:0046501)3.80885424
11regulation of cholesterol storage (GO:0010885)3.78400874
12regulation of interferon-beta biosynthetic process (GO:0045357)3.66035561
13antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.61499059
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.61499059
15protein insertion into membrane (GO:0051205)3.60721024
16protoporphyrinogen IX biosynthetic process (GO:0006782)3.47048563
17regulation of sequestering of triglyceride (GO:0010889)3.46238235
18plasma lipoprotein particle clearance (GO:0034381)3.37757034
19positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.37079723
20peptidyl-glutamic acid carboxylation (GO:0017187)3.24373491
21protein carboxylation (GO:0018214)3.24373491
22hemoglobin metabolic process (GO:0020027)3.17890376
23pentose-phosphate shunt (GO:0006098)3.17550044
24regulation of integrin-mediated signaling pathway (GO:2001044)3.13181630
25response to host immune response (GO:0052572)3.13050212
26response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.13050212
27positive regulation of triglyceride metabolic process (GO:0090208)3.09514187
28negative regulation of protein activation cascade (GO:2000258)3.09303224
29negative regulation of complement activation (GO:0045916)3.09240298
30triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.07423867
31positive regulation of triglyceride biosynthetic process (GO:0010867)3.05061714
32cellular response to thyroid hormone stimulus (GO:0097067)3.04129230
33plasma lipoprotein particle assembly (GO:0034377)3.03465348
34antigen processing and presentation of endogenous antigen (GO:0019883)3.02479985
35protein-lipid complex assembly (GO:0065005)3.00702928
36alpha-linolenic acid metabolic process (GO:0036109)2.99873231
37killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.98759006
38disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.98759006
39positive regulation of fatty acid beta-oxidation (GO:0032000)2.98504894
40fibrinolysis (GO:0042730)2.97017423
41heme biosynthetic process (GO:0006783)2.96576936
42regulation of triglyceride catabolic process (GO:0010896)2.94854390
43positive regulation of interferon-alpha production (GO:0032727)2.93764582
44NADPH regeneration (GO:0006740)2.92506932
45blood coagulation, intrinsic pathway (GO:0007597)2.92290811
46response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.91990449
47response to host (GO:0075136)2.91990449
48response to host defenses (GO:0052200)2.91990449
49fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.91225724
50positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.91100813
51natural killer cell mediated cytotoxicity (GO:0042267)2.90785201
52natural killer cell mediated immunity (GO:0002228)2.90785201
53apoptotic cell clearance (GO:0043277)2.89586581
54macrophage activation involved in immune response (GO:0002281)2.87764491
55complement activation, alternative pathway (GO:0006957)2.87249890
56antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.86825362
57sulfur amino acid catabolic process (GO:0000098)2.85392594
58porphyrin-containing compound biosynthetic process (GO:0006779)2.83665526
59ethanol oxidation (GO:0006069)2.83594993
60iron ion import (GO:0097286)2.81755896
61lysine catabolic process (GO:0006554)2.81487010
62lysine metabolic process (GO:0006553)2.81487010
63very-low-density lipoprotein particle assembly (GO:0034379)2.81403331
64positive regulation of receptor recycling (GO:0001921)2.81089816
65regulation of platelet activation (GO:0010543)2.80830183
66heme metabolic process (GO:0042168)2.79487426
67regulation of protein activation cascade (GO:2000257)2.79455695
68positive regulation of coagulation (GO:0050820)2.77733976
69regulation of interferon-alpha production (GO:0032647)2.76537270
70regulation of complement activation (GO:0030449)2.76419078
71positive regulation of lipid storage (GO:0010884)2.75689540
72regulation of female gonad development (GO:2000194)2.73379105
73protein activation cascade (GO:0072376)2.73077189
74negative regulation of humoral immune response (GO:0002921)2.71662607
75regulation of platelet aggregation (GO:0090330)2.70502621
76positive regulation of hemostasis (GO:1900048)2.70418906
77positive regulation of blood coagulation (GO:0030194)2.70418906
78positive regulation of fatty acid oxidation (GO:0046321)2.70098358
79negative regulation of hemostasis (GO:1900047)2.68291510
80negative regulation of blood coagulation (GO:0030195)2.68291510
81positive regulation of endothelial cell apoptotic process (GO:2000353)2.67384762
82porphyrin-containing compound metabolic process (GO:0006778)2.67092737
83complement activation (GO:0006956)2.65318175
84regulation of fatty acid beta-oxidation (GO:0031998)2.65314091
85negative regulation of erythrocyte differentiation (GO:0045647)2.63553060
86protein-lipid complex subunit organization (GO:0071825)2.63518119
87plasma lipoprotein particle organization (GO:0071827)2.62477744
88positive regulation of lipid catabolic process (GO:0050996)2.62341635
89neutrophil activation involved in immune response (GO:0002283)2.61882092
90high-density lipoprotein particle remodeling (GO:0034375)2.61503848
91negative regulation of lipid storage (GO:0010888)2.59943197
92fatty acid oxidation (GO:0019395)2.59861777
93response to thyroid hormone (GO:0097066)2.58679953
94regulation of macrophage chemotaxis (GO:0010758)2.58679726
95complement activation, classical pathway (GO:0006958)2.58431039
96fibril organization (GO:0097435)2.58367144
97negative regulation of coagulation (GO:0050819)2.56845279
98fatty acid beta-oxidation (GO:0006635)2.56152790
99negative regulation of fibrinolysis (GO:0051918)2.56070889
100respiratory burst (GO:0045730)2.55709033
101brown fat cell differentiation (GO:0050873)2.55566358
102regulation of macrophage derived foam cell differentiation (GO:0010743)2.55307812
103lipid oxidation (GO:0034440)2.54419525
104defense response to fungus (GO:0050832)2.54092715
105cysteine metabolic process (GO:0006534)2.53639385
106phospholipid homeostasis (GO:0055091)2.53543153
107carnitine metabolic process (GO:0009437)2.53540131
108cholesterol efflux (GO:0033344)2.53047249
109regulation of hemostasis (GO:1900046)2.52894512
110regulation of blood coagulation (GO:0030193)2.52894512
111angiogenesis involved in wound healing (GO:0060055)2.52465500
112reverse cholesterol transport (GO:0043691)2.52422787
113negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.51600391
114endothelium development (GO:0003158)2.51272105
115phospholipid efflux (GO:0033700)2.50879120
116response to fungus (GO:0009620)2.50607341
117regulation of fatty acid oxidation (GO:0046320)2.50247163
118positive regulation of wound healing (GO:0090303)2.49558088
119regulation of membrane protein ectodomain proteolysis (GO:0051043)2.48991809
120pinocytosis (GO:0006907)2.47555851
121response to peptidoglycan (GO:0032494)2.47447913
122platelet degranulation (GO:0002576)2.47354833
123membrane protein intracellular domain proteolysis (GO:0031293)2.47208951
124positive regulation of triglyceride lipase activity (GO:0061365)2.46630440
125positive regulation of lipoprotein lipase activity (GO:0051006)2.46630440
126regulation of triglyceride metabolic process (GO:0090207)2.46303776
127negative regulation of granulocyte differentiation (GO:0030853)2.46144997
128ethanol metabolic process (GO:0006067)2.45301091
129negative regulation of platelet activation (GO:0010544)2.45226197
130plasma lipoprotein particle remodeling (GO:0034369)2.44682131
131macromolecular complex remodeling (GO:0034367)2.44682131
132regulation of coagulation (GO:0050818)2.42585722
133negative regulation of protein localization to plasma membrane (GO:1903077)2.42256788
134positive regulation of extracellular matrix organization (GO:1903055)2.41900549
135extracellular fibril organization (GO:0043206)2.41597301
136hyaluronan catabolic process (GO:0030214)2.40129788
137surfactant homeostasis (GO:0043129)2.39443250
138regulation of T-helper 1 cell differentiation (GO:0045625)2.37698070
139positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.35253273
140leukocyte migration involved in inflammatory response (GO:0002523)2.34945282
141acute-phase response (GO:0006953)2.33802330
142barbed-end actin filament capping (GO:0051016)2.32611675
143negative regulation of nitric oxide biosynthetic process (GO:0045019)2.32577217
144detection of molecule of bacterial origin (GO:0032490)2.31498956
145thrombin receptor signaling pathway (GO:0070493)2.30888998
146low-density lipoprotein particle remodeling (GO:0034374)2.30736136
147negative regulation of wound healing (GO:0061045)2.28887225
148regulation of apoptotic cell clearance (GO:2000425)2.28350642
149regulation of humoral immune response (GO:0002920)2.28202369
150gas transport (GO:0015669)2.27023634
151positive regulation of osteoblast proliferation (GO:0033690)2.25991525
152peptide catabolic process (GO:0043171)2.25550428
153triglyceride catabolic process (GO:0019433)2.25409647
154platelet aggregation (GO:0070527)2.23988128
155detection of external biotic stimulus (GO:0098581)2.23960485
156detection of other organism (GO:0098543)2.23146095
157regulation of fibrinolysis (GO:0051917)2.22895228
158oxygen transport (GO:0015671)2.19598505
159negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.18339895
160keratan sulfate catabolic process (GO:0042340)2.17874491
161adhesion of symbiont to host cell (GO:0044650)2.17679288
162virion attachment to host cell (GO:0019062)2.17679288
163cellular extravasation (GO:0045123)2.17074627
164regulation of integrin activation (GO:0033623)2.14810995
165positive regulation of cholesterol efflux (GO:0010875)2.14194105
166detection of bacterium (GO:0016045)2.14091028
167nitrogen cycle metabolic process (GO:0071941)2.13860931
168adhesion of symbiont to host (GO:0044406)2.13348358
169megakaryocyte development (GO:0035855)2.11703319
170hypotonic response (GO:0006971)2.11256394
171positive regulation of fatty acid biosynthetic process (GO:0045723)2.10573933
172negative regulation of focal adhesion assembly (GO:0051895)2.09775899
173negative regulation of cell junction assembly (GO:1901889)2.09775899
174negative regulation of adherens junction organization (GO:1903392)2.09775899
175regulation of T-helper 2 cell differentiation (GO:0045628)2.09414330
176positive regulation of gamma-delta T cell activation (GO:0046645)2.09267183

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.56153819
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.46205908
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.42063450
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.20579055
5* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.18195204
6LXR_22158963_ChIP-Seq_LIVER_Mouse2.82080828
7STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.61171619
8MYB_21317192_ChIP-Seq_ERMYB_Mouse2.59083642
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.54756626
10GATA1_22025678_ChIP-Seq_K562_Human2.51546087
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.47003242
12* IRF8_27001747_Chip-Seq_BMDM_Mouse2.46472673
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.35608774
14* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.34700753
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.27723348
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.27658003
17BP1_19119308_ChIP-ChIP_Hs578T_Human2.26046177
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.24669604
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.17917550
20CLOCK_20551151_ChIP-Seq_293T_Human2.16678397
21SMAD_19615063_ChIP-ChIP_OVARY_Human2.13212470
22* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.12743025
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.11870182
24CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.08949496
25ZNF263_19887448_ChIP-Seq_K562_Human2.08310392
26EGR1_23403033_ChIP-Seq_LIVER_Mouse2.01394211
27Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.99359882
28FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.92999043
29VDR_21846776_ChIP-Seq_THP-1_Human1.92128599
30ESR2_21235772_ChIP-Seq_MCF-7_Human1.87341131
31GATA1_19941826_ChIP-Seq_K562_Human1.86356370
32STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.84363703
33TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.83940687
34EGR1_19374776_ChIP-ChIP_THP-1_Human1.83703947
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.73850494
36* GATA1_19941827_ChIP-Seq_MEL_Mouse1.71459151
37TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.70840803
38SCL_19346495_ChIP-Seq_HPC-7_Human1.69676195
39RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.65134871
40ESR1_21235772_ChIP-Seq_MCF-7_Human1.57928559
41CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.56892127
42STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.56495159
43LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.56000854
44MAF_26560356_Chip-Seq_TH1_Human1.54490367
45ELK3_25401928_ChIP-Seq_HUVEC_Human1.52441726
46VDR_24763502_ChIP-Seq_THP-1_Human1.51405656
47* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.50634519
48TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49577367
49GATA2_19941826_ChIP-Seq_K562_Human1.47390112
50* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.47119170
51* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.46051141
52NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.45724947
53RUNX1_22412390_ChIP-Seq_EML_Mouse1.43992606
54RUNX_20019798_ChIP-Seq_JUKART_Human1.42837771
55KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.41947820
56MYC_22102868_ChIP-Seq_BL_Human1.41903293
57GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.40524415
58LXR_22292898_ChIP-Seq_THP-1_Human1.39584638
59TCF7_22412390_ChIP-Seq_EML_Mouse1.39114948
60STAT4_19710469_ChIP-ChIP_TH1__Mouse1.38486068
61PPAR_26484153_Chip-Seq_NCI-H1993_Human1.37984255
62LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.35736244
63PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.34920914
64SPI1_23127762_ChIP-Seq_K562_Human1.29700187
65KDM2B_26808549_Chip-Seq_SUP-B15_Human1.29412392
66KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.28495281
67SALL4_18804426_ChIP-ChIP_XEN_Mouse1.28254130
68ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.25334110
69IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.23505868
70SOX2_20726797_ChIP-Seq_SW620_Human1.23265316
71RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.22299383
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21952125
73FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.21837403
74MYB_26560356_Chip-Seq_TH2_Human1.21200376
75E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.20828142
76ATF3_27146783_Chip-Seq_COLON_Human1.19340315
77TP63_17297297_ChIP-ChIP_HaCaT_Human1.17937900
78UTX_26944678_Chip-Seq_JUKART_Human1.17816137
79RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.16607245
80* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.15973078
81KDM2B_26808549_Chip-Seq_DND41_Human1.15925475
82PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15848806
83EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.15161012
84GATA2_21666600_ChIP-Seq_HMVEC_Human1.14949100
85FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.13441170
86SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.12941016
87GATA2_22383799_ChIP-Seq_G1ME_Mouse1.12536839
88PU_27001747_Chip-Seq_BMDM_Mouse1.12367579
89CJUN_26792858_Chip-Seq_BT549_Human1.12191990
90RACK7_27058665_Chip-Seq_MCF-7_Human1.10988828
91* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.10808603
92* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.10808603
93HIF1A_21447827_ChIP-Seq_MCF-7_Human1.10418983
94TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.10417992
95* GATA3_27048872_Chip-Seq_THYMUS_Human1.10082336
96CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08464818
97CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.07702637
98NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.07170681
99NRF2_20460467_ChIP-Seq_MEFs_Mouse1.07170681
100PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07159898
101P300_27058665_Chip-Seq_ZR-75-30cells_Human1.06926235
102CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06824631
103JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05702180
104SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04312303
105* SPI1_23547873_ChIP-Seq_NB4_Human1.04203196
106* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02363670
107JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02167723
108FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.01849204
109STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.00287719
110BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99742573
111TRIM28_21343339_ChIP-Seq_HEK293_Human0.99427965
112SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.98887148
113ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.98034355
114KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.97174599
115STAT6_21828071_ChIP-Seq_BEAS2B_Human0.97141436
116SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.97080139
117KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96699821
118ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.96084425
119* TBX20_22080862_ChIP-Seq_HEART_Mouse0.96050064
120* TBX20_22328084_ChIP-Seq_HEART_Mouse0.96050064
121SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95690699
122* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.95011338
123GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.94659090
124ESR1_20079471_ChIP-ChIP_T-47D_Human0.93141053
125NCOR1_26117541_ChIP-Seq_K562_Human0.92230976
126NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.91890591
127FOXO3_23340844_ChIP-Seq_DLD1_Human0.91501590
128PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.90764103
129VDR_24787735_ChIP-Seq_THP-1_Human0.90458316
130BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.90090143
131MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.88869647
132* FOXA2_19822575_ChIP-Seq_HepG2_Human0.86553464

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001984_abnormal_olfaction4.62441543
2MP0003656_abnormal_erythrocyte_physiolo3.23836224
3MP0005058_abnormal_lysosome_morphology2.98594822
4MP0009840_abnormal_foam_cell2.92567094
5MP0005360_urolithiasis2.68951743
6MP0002139_abnormal_hepatobiliary_system2.67930520
7MP0003303_peritoneal_inflammation2.63685253
8MP0003806_abnormal_nucleotide_metabolis2.46314940
9MP0003705_abnormal_hypodermis_morpholog2.27128481
10MP0003191_abnormal_cellular_cholesterol2.25740145
11MP0003436_decreased_susceptibility_to2.14304977
12MP0003300_gastrointestinal_ulcer2.06089020
13MP0008004_abnormal_stomach_pH2.05356367
14MP0008875_abnormal_xenobiotic_pharmacok2.02135978
15MP0004147_increased_porphyrin_level1.98520723
16MP0005365_abnormal_bile_salt1.96399136
17MP0006054_spinal_hemorrhage1.91465094
18MP0010329_abnormal_lipoprotein_level1.88846552
19MP0003724_increased_susceptibility_to1.81147250
20MP0008438_abnormal_cutaneous_collagen1.75416981
21MP0003950_abnormal_plasma_membrane1.72901019
22MP0003828_pulmonary_edema1.69832520
23MP0004130_abnormal_muscle_cell1.69317446
24MP0002419_abnormal_innate_immunity1.68100374
25MP0000343_altered_response_to1.67859354
26MP0003252_abnormal_bile_duct1.66575597
27MP0003279_aneurysm1.66249905
28MP0005083_abnormal_biliary_tract1.65391074
29MP0005085_abnormal_gallbladder_physiolo1.64578887
30MP0000609_abnormal_liver_physiology1.61252596
31MP0009785_altered_susceptibility_to1.59466082
32MP0003566_abnormal_cell_adhesion1.58178473
33MP0001835_abnormal_antigen_presentation1.52461909
34MP0005464_abnormal_platelet_physiology1.50970047
35MP0006082_CNS_inflammation1.48616422
36MP0005319_abnormal_enzyme/_coenzyme1.47373355
37MP0000604_amyloidosis1.46392883
38MP0004272_abnormal_basement_membrane1.42341158
39MP0005025_abnormal_response_to1.38862166
40MP0003091_abnormal_cell_migration1.36876374
41MP0001533_abnormal_skeleton_physiology1.35126700
42MP0009764_decreased_sensitivity_to1.35002784
43MP0001545_abnormal_hematopoietic_system1.34991626
44MP0005397_hematopoietic_system_phenotyp1.34991626
45MP0002998_abnormal_bone_remodeling1.30053968
46MP0004510_myositis1.28380290
47MP0008469_abnormal_protein_level1.27969324
48MP0003075_altered_response_to1.25681825
49MP0005584_abnormal_enzyme/coenzyme_acti1.25314896
50MP0003172_abnormal_lysosome_physiology1.24230821
51MP0003186_abnormal_redox_activity1.24026680
52MP0004883_abnormal_blood_vessel1.22136878
53MP0008260_abnormal_autophagy1.21344419
54MP0005503_abnormal_tendon_morphology1.20921230
55MP0010307_abnormal_tumor_latency1.19597405
56MP0002877_abnormal_melanocyte_morpholog1.18930882
57MP0003453_abnormal_keratinocyte_physiol1.16312497
58MP0005000_abnormal_immune_tolerance1.15153070
59MP0009278_abnormal_bone_marrow1.14586343
60MP0010352_gastrointestinal_tract_polyps1.14174804
61MP0009333_abnormal_splenocyte_physiolog1.12450707
62MP0000685_abnormal_immune_system1.12333444
63MP0005670_abnormal_white_adipose1.11476663
64MP0010155_abnormal_intestine_physiology1.10619526
65MP0001845_abnormal_inflammatory_respons1.10371614
66MP0004947_skin_inflammation1.09432474
67MP0005387_immune_system_phenotype1.09088147
68MP0001790_abnormal_immune_system1.09088147
69MP0002405_respiratory_system_inflammati1.07929586
70MP0009763_increased_sensitivity_to1.07537480
71MP0002118_abnormal_lipid_homeostasis1.07028253
72MP0002452_abnormal_antigen_presenting1.04758637
73MP0004782_abnormal_surfactant_physiolog1.04255730
74MP0000465_gastrointestinal_hemorrhage1.02290459
75MP0002295_abnormal_pulmonary_circulatio1.02207099
76MP0001853_heart_inflammation1.01557061
77MP0010368_abnormal_lymphatic_system1.01359528
78MP0001666_abnormal_nutrient_absorption1.01352885
79MP0000598_abnormal_liver_morphology1.00526322
80MP0005166_decreased_susceptibility_to0.98782935
81MP0005666_abnormal_adipose_tissue0.97407963
82MP0002971_abnormal_brown_adipose0.97389028
83MP0005595_abnormal_vascular_smooth0.96758973
84MP0005390_skeleton_phenotype0.96201368
85MP0004185_abnormal_adipocyte_glucose0.96053268
86MP0005451_abnormal_body_composition0.95650876
87MP0002166_altered_tumor_susceptibility0.95511900
88MP0001800_abnormal_humoral_immune0.92907159
89MP0003690_abnormal_glial_cell0.92881105
90MP0002138_abnormal_hepatobiliary_system0.92230217
91MP0000858_altered_metastatic_potential0.90195772
92MP0001849_ear_inflammation0.90121410
93MP0002933_joint_inflammation0.89027316
94MP0009115_abnormal_fat_cell0.88734744
95MP0005165_increased_susceptibility_to0.87531127
96MP0009643_abnormal_urine_homeostasis0.86827457
97MP0006138_congestive_heart_failure0.86748068
98MP0002723_abnormal_immune_serum0.86442038
99MP0000249_abnormal_blood_vessel0.86261381
100MP0003045_fibrosis0.85080935
101MP0002148_abnormal_hypersensitivity_rea0.85015069
102MP0001819_abnormal_immune_cell0.84119648
103MP0005164_abnormal_response_to0.83153161
104MP0000490_abnormal_crypts_of0.83057912
105MP0002420_abnormal_adaptive_immunity0.82480471
106MP0003646_muscle_fatigue0.80691252
107MP0002332_abnormal_exercise_endurance0.80419185
108MP0008775_abnormal_heart_ventricle0.80281075
109MP0003448_altered_tumor_morphology0.79848831
110MP0000767_abnormal_smooth_muscle0.79523513
111MP0005275_abnormal_skin_tensile0.78593023
112MP0005167_abnormal_blood-brain_barrier0.77352143
113MP0005023_abnormal_wound_healing0.76797118
114MP0001879_abnormal_lymphatic_vessel0.76647730
115MP0000689_abnormal_spleen_morphology0.75488567
116MP0001958_emphysema0.74918709
117MP0008873_increased_physiological_sensi0.73206199
118MP0005076_abnormal_cell_differentiation0.72732480
119MP0001851_eye_inflammation0.72190544
120MP0005375_adipose_tissue_phenotype0.72053692
121MP0001542_abnormal_bone_strength0.71509188

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)4.21145519
2Purpura (HP:0000979)4.09596482
3Vacuolated lymphocytes (HP:0001922)3.79065779
4Increased mean platelet volume (HP:0011877)3.73525182
5Menorrhagia (HP:0000132)3.69851741
6Systemic lupus erythematosus (HP:0002725)3.65776670
7Gingival bleeding (HP:0000225)3.64236273
8Abnormal platelet volume (HP:0011876)3.57360349
9Deep venous thrombosis (HP:0002625)3.56045982
10Increased cerebral lipofuscin (HP:0011813)3.55694765
11Eczematoid dermatitis (HP:0000976)3.52240274
12Recurrent gram-negative bacterial infections (HP:0005420)3.47359788
13Petechiae (HP:0000967)3.41970224
14Recurrent abscess formation (HP:0002722)3.18817524
15Xanthomatosis (HP:0000991)3.18787805
16Complement deficiency (HP:0004431)3.13048060
17Aortic aneurysm (HP:0004942)3.12731517
18Dysostosis multiplex (HP:0000943)3.10766366
19Myocardial infarction (HP:0001658)2.99826326
20* Poikilocytosis (HP:0004447)2.98734589
21Abnormality of glycolipid metabolism (HP:0010969)2.97930960
22Abnormality of liposaccharide metabolism (HP:0010968)2.97930960
23Abnormality of glycosphingolipid metabolism (HP:0004343)2.97930960
24Orchitis (HP:0100796)2.92749773
25Myositis (HP:0100614)2.92717382
26Recurrent bacterial skin infections (HP:0005406)2.92326134
27Protrusio acetabuli (HP:0003179)2.89302913
28Abnormality of the nasal mucosa (HP:0000433)2.88576526
29Hypochromic microcytic anemia (HP:0004840)2.86949920
30Increased neuronal autofluorescent lipopigment (HP:0002074)2.84778054
31Abnormality of complement system (HP:0005339)2.82929482
32Reticulocytosis (HP:0001923)2.81078478
33Nasal polyposis (HP:0100582)2.78660032
34Joint hemorrhage (HP:0005261)2.77393169
35Abnormality of macrophages (HP:0004311)2.76344693
36Polycythemia (HP:0001901)2.74768309
37Increased serum ferritin (HP:0003281)2.70726796
38Hypoalphalipoproteinemia (HP:0003233)2.69496460
39Cholelithiasis (HP:0001081)2.69262078
40Abnormality of iron homeostasis (HP:0011031)2.61018858
41Palpitations (HP:0001962)2.58068070
42Urinary glycosaminoglycan excretion (HP:0003541)2.52827795
43Mucopolysacchariduria (HP:0008155)2.52827795
44Vascular tortuosity (HP:0004948)2.50360418
45Acanthocytosis (HP:0001927)2.46997697
46Amyloidosis (HP:0011034)2.43100255
47Hypercholesterolemia (HP:0003124)2.41737950
48Osteolytic defects of the phalanges of the hand (HP:0009771)2.40943103
49Osteolytic defects of the hand bones (HP:0009699)2.40943103
50Autoimmune thrombocytopenia (HP:0001973)2.40847721
51Axonal loss (HP:0003447)2.40116354
52Cholecystitis (HP:0001082)2.40046609
53Abnormal gallbladder physiology (HP:0012438)2.40046609
54Spontaneous hematomas (HP:0007420)2.39248982
55Esophageal varix (HP:0002040)2.36754402
56Abnormality of mucopolysaccharide metabolism (HP:0011020)2.36110491
57Abnormality of polysaccharide metabolism (HP:0011012)2.36110491
58Abnormality of glycosaminoglycan metabolism (HP:0004371)2.36110491
59Hyperlipoproteinemia (HP:0010980)2.35690066
60Abnormal gallbladder morphology (HP:0012437)2.34692858
61Asymmetric septal hypertrophy (HP:0001670)2.34134965
62Abnormality of transition element cation homeostasis (HP:0011030)2.33756221
63Peritonitis (HP:0002586)2.33071146
64Urticaria (HP:0001025)2.32462375
65Abnormality of monocarboxylic acid metabolism (HP:0010996)2.31184538
66Aortic dissection (HP:0002647)2.30624794
67Abnormality of the common coagulation pathway (HP:0010990)2.30532565
68Disinhibition (HP:0000734)2.29912806
69Vertebral compression fractures (HP:0002953)2.29673289
70Hypolipoproteinemia (HP:0010981)2.28359966
71Hematochezia (HP:0002573)2.28328495
72Hepatocellular carcinoma (HP:0001402)2.28200961
73Premature rupture of membranes (HP:0001788)2.26100107
74Abnormality of the heme biosynthetic pathway (HP:0010472)2.26040808
75Interstitial pulmonary disease (HP:0006530)2.24345567
76Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.24032651
77Nausea (HP:0002018)2.23992592
78Esophageal neoplasm (HP:0100751)2.23542759
79Neoplasm of head and neck (HP:0012288)2.23542759
80Mitral stenosis (HP:0001718)2.22001403
81Hyperbilirubinemia (HP:0002904)2.18273444
82Intrahepatic cholestasis (HP:0001406)2.17671867
83Tetraparesis (HP:0002273)2.16068974
84Loss of speech (HP:0002371)2.16014498
85Pustule (HP:0200039)2.14656344
86Hyperammonemia (HP:0001987)2.14330742
87Arterial tortuosity (HP:0005116)2.13895804
88Global brain atrophy (HP:0002283)2.10725669
89Hemorrhage of the eye (HP:0011885)2.10325770
90Optic neuritis (HP:0100653)2.08760739
91Retrobulbar optic neuritis (HP:0100654)2.08760739
92Microcytic anemia (HP:0001935)2.07611711
93Myoglobinuria (HP:0002913)2.07574521
94Conjunctival hamartoma (HP:0100780)2.07361912
95Abnormality of fatty-acid metabolism (HP:0004359)2.06902720
96Hypertriglyceridemia (HP:0002155)2.06382150
97Bruising susceptibility (HP:0000978)2.02395695
98Glomerulonephritis (HP:0000099)2.02175468
99Mucosal telangiectasiae (HP:0100579)2.01781010
100Joint swelling (HP:0001386)2.00550448
101Aneurysm (HP:0002617)1.99708313
102Nephritis (HP:0000123)1.98436956
103Abnormality of glutamine family amino acid metabolism (HP:0010902)1.97921396
104Cerebral aneurysm (HP:0004944)1.97567223
105Abnormal platelet function (HP:0011869)1.97166957
106Impaired platelet aggregation (HP:0003540)1.97166957
107Pulmonary embolism (HP:0002204)1.96794958
108Gingivitis (HP:0000230)1.96608566
109Nonimmune hydrops fetalis (HP:0001790)1.95666440
110Paralysis (HP:0003470)1.94723799
111Thrombophlebitis (HP:0004418)1.94073316
112Abnormality of the vasculature of the conjunctiva (HP:0008054)1.93910818
113Distal lower limb muscle weakness (HP:0009053)1.93822023
114Arterial thrombosis (HP:0004420)1.93657540
115Increased density of long bones (HP:0006392)1.93183247
116Rhabdomyolysis (HP:0003201)1.93103645
117Abnormality of macular pigmentation (HP:0008002)1.91839516
118Right ventricular cardiomyopathy (HP:0011663)1.91632158
119Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.91573284
120Hypobetalipoproteinemia (HP:0003563)1.91329576
121Dilatation of the ascending aorta (HP:0005111)1.90741913
122Elevated erythrocyte sedimentation rate (HP:0003565)1.90632599
123Hydroxyprolinuria (HP:0003080)1.89865587
124Abnormality of proline metabolism (HP:0010907)1.89865587
125Epistaxis (HP:0000421)1.88870917
126Wormian bones (HP:0002645)1.88717157
127Conjunctival telangiectasia (HP:0000524)1.87786738
128Spondylolisthesis (HP:0003302)1.83214472
129Cervical subluxation (HP:0003308)1.80412552
130Abnormality of aromatic amino acid family metabolism (HP:0004338)1.77129158
131Muscle fiber splitting (HP:0003555)1.76834614
132Pulmonary infiltrates (HP:0002113)1.74767532
133Autoimmune hemolytic anemia (HP:0001890)1.74376599
134Keratoconjunctivitis sicca (HP:0001097)1.73112273
135Increased variability in muscle fiber diameter (HP:0003557)1.71255453
136Skin nodule (HP:0200036)1.71134409
137Hepatosplenomegaly (HP:0001433)1.69950448
138Cardiovascular calcification (HP:0011915)1.68401076
139Gastrointestinal infarctions (HP:0005244)1.64857311

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.13683397
2ERN13.66454557
3TAOK33.34731613
4PKN23.02793434
5PRPF4B2.61155310
6TTN2.56028377
7TBK12.29429739
8RIPK12.25113132
9EEF2K2.18259766
10TGFBR22.13425952
11CAMK1D2.08577208
12KDR2.03429576
13TYK21.94114478
14RIPK41.81430992
15TAOK21.72510792
16GRK71.69011139
17MAP2K31.64200671
18KIT1.60341051
19DDR21.53823494
20EPHB11.53769869
21JAK11.52997405
22MAPKAPK31.52113604
23STK101.49618237
24SIK11.46599542
25STK241.46173634
26PHKG21.46047154
27PHKG11.46047154
28PDGFRA1.44161365
29IRAK31.43965438
30TRPM71.42783663
31LRRK21.37807097
32PIM21.37574155
33PTK61.36653545
34FLT31.34779901
35BCKDK1.31492548
36EIF2AK11.31139671
37CAMK1G1.27473571
38BMPR21.22464020
39FER1.22153924
40MAP4K11.20724197
41MAP3K31.17527873
42MAP3K101.16011444
43FES1.13730816
44MAP3K141.12631379
45GRK51.11628628
46MAP3K11.08509338
47NEK91.07259761
48STK31.06301030
49RPS6KA41.05117955
50GRK61.04225653
51CDC42BPA1.03479494
52JAK21.02587314
53CDK61.00985211
54MATK0.99295373
55FGFR40.98586757
56IKBKE0.95865647
57IRAK40.92697611
58ZAP700.91654433
59PDGFRB0.90757795
60BLK0.89981059
61IRAK10.88786423
62TIE10.87857249
63JAK30.86917488
64BMX0.86146161
65MST1R0.83355574
66PIM10.83322331
67TAOK10.83103665
68MAPK110.82450966
69FGR0.82258116
70CSK0.81988773
71PRKAA20.81940638
72PDPK10.79638079
73ILK0.78485630
74MAPK120.75547584
75CDK120.73194213
76TXK0.72643585
77MAP3K20.70945356
78MARK30.70323133
79ACVR1B0.70140826
80BTK0.69873493
81MAP3K60.69707813
82CAMKK20.68269901
83STK40.67816079
84PDK20.67102687
85MAP3K130.66956830
86TESK10.66531290
87LYN0.65706678
88DYRK1B0.65619398
89EPHA30.65241599
90PAK20.64456534
91CLK10.63867668
92FGFR30.63688540
93CSF1R0.63656937
94HCK0.62921441
95MAPK70.62286684
96PAK40.62210111
97SCYL20.62051065
98ABL20.61826755
99HIPK20.61513805
100PTK20.61224284
101PRKD10.60386495
102LMTK20.60262673
103MAPKAPK20.58314824
104MAPK40.57253159
105MAP3K50.56190350
106TEC0.54856590
107EGFR0.54392516
108IKBKB0.54073278
109LCK0.53680593
110ICK0.53488191
111NUAK10.52489115
112MAP3K80.52331671
113CDK40.52236180
114SYK0.52193017
115MOS0.51713333
116PRKG20.51477954
117ADRBK10.50383462
118NLK0.50278106
119MAP3K110.50044727
120RPS6KA20.49883108
121SGK30.49785550
122PDK10.48930675
123GSK3A0.48575753
124KSR20.47169548
125DMPK0.46104645
126IGF1R0.45029811
127PAK30.44851175
128ABL10.43871377
129PTK2B0.43570857
130CDK90.43366804
131RET0.43183129
132PIK3CG0.41462493
133PRKAA10.41261062
134NEK20.41178227
135ERBB30.40740587
136ITK0.40523967
137NME20.40183376
138MYLK0.38583024
139MAP2K20.38460093
140RPS6KA60.38267817
141MAP3K70.37484788
142CAMK2D0.37263400
143MAP2K10.35846651
144DAPK20.34667463
145NEK10.34535100

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047403.30502289
2Caffeine metabolism_Homo sapiens_hsa002322.84855172
3Staphylococcus aureus infection_Homo sapiens_hsa051502.61227850
4Fatty acid degradation_Homo sapiens_hsa000712.48347985
5Complement and coagulation cascades_Homo sapiens_hsa046102.32700967
6Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.07151784
7PPAR signaling pathway_Homo sapiens_hsa033202.07120311
8Primary bile acid biosynthesis_Homo sapiens_hsa001202.02954003
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.96517386
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.86326947
11Glycosaminoglycan degradation_Homo sapiens_hsa005311.84564341
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.73087345
13Arginine biosynthesis_Homo sapiens_hsa002201.70667889
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.69383110
15Lysosome_Homo sapiens_hsa041421.65224976
16Pentose and glucuronate interconversions_Homo sapiens_hsa000401.61643694
17Propanoate metabolism_Homo sapiens_hsa006401.60248731
18Fatty acid metabolism_Homo sapiens_hsa012121.57822278
19Malaria_Homo sapiens_hsa051441.57402405
20beta-Alanine metabolism_Homo sapiens_hsa004101.56627664
21ECM-receptor interaction_Homo sapiens_hsa045121.53635024
22ABC transporters_Homo sapiens_hsa020101.52830254
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.52274684
24Leishmaniasis_Homo sapiens_hsa051401.51783048
25Other glycan degradation_Homo sapiens_hsa005111.49967069
26Nitrogen metabolism_Homo sapiens_hsa009101.49364587
27Starch and sucrose metabolism_Homo sapiens_hsa005001.41792767
28Carbon metabolism_Homo sapiens_hsa012001.40245898
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.39090547
30Histidine metabolism_Homo sapiens_hsa003401.35731824
31Bile secretion_Homo sapiens_hsa049761.30837107
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.30195729
33Fatty acid biosynthesis_Homo sapiens_hsa000611.28342908
34Osteoclast differentiation_Homo sapiens_hsa043801.27511462
35Tryptophan metabolism_Homo sapiens_hsa003801.23884039
36Adipocytokine signaling pathway_Homo sapiens_hsa049201.23641056
37Pentose phosphate pathway_Homo sapiens_hsa000301.20747512
38Tyrosine metabolism_Homo sapiens_hsa003501.20156685
39Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.18869948
40Prion diseases_Homo sapiens_hsa050201.17523506
41Peroxisome_Homo sapiens_hsa041461.16281302
42African trypanosomiasis_Homo sapiens_hsa051431.16125744
43Drug metabolism - other enzymes_Homo sapiens_hsa009831.13763949
44Toll-like receptor signaling pathway_Homo sapiens_hsa046201.08791610
45Pyruvate metabolism_Homo sapiens_hsa006201.04543000
46Toxoplasmosis_Homo sapiens_hsa051451.04138345
47Tuberculosis_Homo sapiens_hsa051521.03875995
48Pertussis_Homo sapiens_hsa051331.02356543
49Arachidonic acid metabolism_Homo sapiens_hsa005901.01748850
50Selenocompound metabolism_Homo sapiens_hsa004500.99189692
51Asthma_Homo sapiens_hsa053100.98343831
52Allograft rejection_Homo sapiens_hsa053300.97099473
53Graft-versus-host disease_Homo sapiens_hsa053320.96858291
54Insulin resistance_Homo sapiens_hsa049310.96165424
55Legionellosis_Homo sapiens_hsa051340.95767277
56Steroid hormone biosynthesis_Homo sapiens_hsa001400.94587508
57Apoptosis_Homo sapiens_hsa042100.93244111
58Amoebiasis_Homo sapiens_hsa051460.92324234
59Fat digestion and absorption_Homo sapiens_hsa049750.91604782
60Sulfur relay system_Homo sapiens_hsa041220.88315243
61Focal adhesion_Homo sapiens_hsa045100.86544481
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.85053334
63Systemic lupus erythematosus_Homo sapiens_hsa053220.84448667
64Rheumatoid arthritis_Homo sapiens_hsa053230.84111931
65Chronic myeloid leukemia_Homo sapiens_hsa052200.83021755
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82650183
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.82231524
68Galactose metabolism_Homo sapiens_hsa000520.81860203
69NOD-like receptor signaling pathway_Homo sapiens_hsa046210.81464679
70Chemical carcinogenesis_Homo sapiens_hsa052040.80266683
71TNF signaling pathway_Homo sapiens_hsa046680.79105681
72Chemokine signaling pathway_Homo sapiens_hsa040620.78157232
73Small cell lung cancer_Homo sapiens_hsa052220.73652018
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.73453827
75Mineral absorption_Homo sapiens_hsa049780.71716067
76Phagosome_Homo sapiens_hsa041450.71037900
77Autoimmune thyroid disease_Homo sapiens_hsa053200.70995951
78Biosynthesis of amino acids_Homo sapiens_hsa012300.70019945
79Sphingolipid metabolism_Homo sapiens_hsa006000.69680652
80Pancreatic cancer_Homo sapiens_hsa052120.69082584
81Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.69007980
82Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.67951760
83Glutathione metabolism_Homo sapiens_hsa004800.66052510
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63380145
85Sulfur metabolism_Homo sapiens_hsa009200.62896048
86Retinol metabolism_Homo sapiens_hsa008300.62823092
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62657196
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61790213
89Leukocyte transendothelial migration_Homo sapiens_hsa046700.59016408
90Hepatitis C_Homo sapiens_hsa051600.58944809
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58822232
92Glycerolipid metabolism_Homo sapiens_hsa005610.58298031
93Antigen processing and presentation_Homo sapiens_hsa046120.57625259
94Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.57271164
95Shigellosis_Homo sapiens_hsa051310.56538652
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56465015
97RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.56438302
98Jak-STAT signaling pathway_Homo sapiens_hsa046300.55984446
99Influenza A_Homo sapiens_hsa051640.55372440
100Measles_Homo sapiens_hsa051620.54138436
101Intestinal immune network for IgA production_Homo sapiens_hsa046720.53581480
102Vascular smooth muscle contraction_Homo sapiens_hsa042700.53468062
103Salmonella infection_Homo sapiens_hsa051320.52524819
104Insulin signaling pathway_Homo sapiens_hsa049100.51445932
105Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.51383465
106B cell receptor signaling pathway_Homo sapiens_hsa046620.50474831
107Viral myocarditis_Homo sapiens_hsa054160.50129741
108Phenylalanine metabolism_Homo sapiens_hsa003600.48928090
109Proteoglycans in cancer_Homo sapiens_hsa052050.48807081
110Hepatitis B_Homo sapiens_hsa051610.48727458
111Hematopoietic cell lineage_Homo sapiens_hsa046400.47863624
112Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47440594
113Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47378736
114Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47199705
115Bladder cancer_Homo sapiens_hsa052190.47163554
116Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.47122486
117Central carbon metabolism in cancer_Homo sapiens_hsa052300.46703844
118Acute myeloid leukemia_Homo sapiens_hsa052210.46667970
119NF-kappa B signaling pathway_Homo sapiens_hsa040640.46611075
120Platelet activation_Homo sapiens_hsa046110.45740443
121Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45509330
122AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45459466
123Lysine degradation_Homo sapiens_hsa003100.44279835
124AMPK signaling pathway_Homo sapiens_hsa041520.44279413
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43989120
126Endocytosis_Homo sapiens_hsa041440.42710527
127Viral carcinogenesis_Homo sapiens_hsa052030.41210054
128Arginine and proline metabolism_Homo sapiens_hsa003300.40579886
129HIF-1 signaling pathway_Homo sapiens_hsa040660.39716151
130Renin-angiotensin system_Homo sapiens_hsa046140.39020608
131Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38675519
132Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36571771

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