STMN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)6.21643815
2neuron cell-cell adhesion (GO:0007158)5.44684673
3sequestering of actin monomers (GO:0042989)4.63873778
4nucleobase catabolic process (GO:0046113)4.58631584
5neuron recognition (GO:0008038)4.47426573
6chaperone-mediated protein transport (GO:0072321)4.33583660
7cell migration in hindbrain (GO:0021535)4.29798879
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.27464963
9mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.10011693
10protein localization to synapse (GO:0035418)4.09972561
11axonal fasciculation (GO:0007413)4.09951200
12energy coupled proton transport, down electrochemical gradient (GO:0015985)4.06231056
13ATP synthesis coupled proton transport (GO:0015986)4.06231056
14vocalization behavior (GO:0071625)4.03746781
15* negative regulation of microtubule polymerization (GO:0031115)3.95898244
16dendritic spine morphogenesis (GO:0060997)3.83386842
17DNA double-strand break processing (GO:0000729)3.78972556
18positive regulation of synapse assembly (GO:0051965)3.71849839
19presynaptic membrane organization (GO:0097090)3.68575334
20presynaptic membrane assembly (GO:0097105)3.64593025
21central nervous system projection neuron axonogenesis (GO:0021952)3.63564403
22synaptic vesicle exocytosis (GO:0016079)3.58791817
23postsynaptic membrane organization (GO:0001941)3.48316393
24layer formation in cerebral cortex (GO:0021819)3.46459722
25establishment of mitochondrion localization (GO:0051654)3.44481123
26behavioral response to nicotine (GO:0035095)3.43755534
27neural tube formation (GO:0001841)3.38961880
28regulation of glutamate receptor signaling pathway (GO:1900449)3.37666637
29regulation of development, heterochronic (GO:0040034)3.33427959
30limb bud formation (GO:0060174)3.32609012
31protein neddylation (GO:0045116)3.27566214
32positive regulation of dendritic spine morphogenesis (GO:0061003)3.26381355
33hippocampus development (GO:0021766)3.19834133
34regulation of alternative mRNA splicing, via spliceosome (GO:0000381)3.16501623
35regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.15356317
36histone H2A acetylation (GO:0043968)3.14311509
37regulation of timing of cell differentiation (GO:0048505)3.12839212
38cerebral cortex radially oriented cell migration (GO:0021799)3.11137770
39gamma-aminobutyric acid transport (GO:0015812)3.10668402
40hindbrain development (GO:0030902)3.09315898
41regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.08500925
42olfactory bulb development (GO:0021772)3.04468868
43mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.03723921
44glycosphingolipid biosynthetic process (GO:0006688)3.03052559
45establishment of integrated proviral latency (GO:0075713)3.02578062
46axon ensheathment in central nervous system (GO:0032291)3.00992066
47central nervous system myelination (GO:0022010)3.00992066
48regulation of respiratory system process (GO:0044065)3.00854832
49somite development (GO:0061053)3.00334139
50dendrite development (GO:0016358)2.98740167
51dendrite morphogenesis (GO:0048813)2.97973677
52G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.91099997
53resolution of meiotic recombination intermediates (GO:0000712)2.91061400
54regulation of synapse assembly (GO:0051963)2.90517563
55regulation of synaptic vesicle exocytosis (GO:2000300)2.90446625
56ionotropic glutamate receptor signaling pathway (GO:0035235)2.89896393
57positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.89518601
58regulation of synapse structural plasticity (GO:0051823)2.87316398
59epithelial cell differentiation involved in kidney development (GO:0035850)2.87236639
60positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.85380963
61regulation of short-term neuronal synaptic plasticity (GO:0048172)2.84171213
62central nervous system neuron axonogenesis (GO:0021955)2.83410359
63mechanosensory behavior (GO:0007638)2.81153047
64regulation of respiratory gaseous exchange (GO:0043576)2.81067243
65sympathetic nervous system development (GO:0048485)2.79284085
66nonmotile primary cilium assembly (GO:0035058)2.78974722
67axon extension (GO:0048675)2.78500131
68positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.77788363
69intraciliary transport (GO:0042073)2.77245141
70positive regulation of mitochondrial fission (GO:0090141)2.75362485
71synaptic transmission, glutamatergic (GO:0035249)2.74113583
72negative regulation of axon extension (GO:0030517)2.73583441
73glutamate receptor signaling pathway (GO:0007215)2.73408463
74protein localization to cilium (GO:0061512)2.73312743
75auditory behavior (GO:0031223)2.72997147
76spinal cord development (GO:0021510)2.70080141
77regulation of collateral sprouting (GO:0048670)2.69581849
78centriole replication (GO:0007099)2.67927796
79establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.67874657
80mitochondrion transport along microtubule (GO:0047497)2.67874657
81synapse assembly (GO:0007416)2.67383411
82neurofilament cytoskeleton organization (GO:0060052)2.66640366
83response to pheromone (GO:0019236)2.66231878
84negative regulation of synaptic transmission, GABAergic (GO:0032229)2.65950775
85negative regulation of axon guidance (GO:1902668)2.65227741
86transmission of nerve impulse (GO:0019226)2.64957930
87peptidyl-arginine omega-N-methylation (GO:0035247)2.64570719
88neuron-neuron synaptic transmission (GO:0007270)2.64206684
89glutamate secretion (GO:0014047)2.63410296
90startle response (GO:0001964)2.63298030
91forebrain neuron differentiation (GO:0021879)2.63078398
92chromatin remodeling at centromere (GO:0031055)2.62919012
93neuronal action potential (GO:0019228)2.61718461
94negative regulation of axonogenesis (GO:0050771)2.61551566
95spermatid nucleus differentiation (GO:0007289)2.60929379
96regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.60865072
97regulation of sarcomere organization (GO:0060297)2.60274609
98positive regulation of synapse maturation (GO:0090129)2.60162193
99exploration behavior (GO:0035640)2.59351675
100protein-cofactor linkage (GO:0018065)2.59065092
101regulation of synapse organization (GO:0050807)2.56487447
102regulation of cilium movement (GO:0003352)2.56378749
103negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.56355685
104cerebellum development (GO:0021549)2.56322684
105peptidyl-arginine methylation (GO:0018216)2.56305067
106peptidyl-arginine N-methylation (GO:0035246)2.56305067
107neuron fate determination (GO:0048664)2.56262953
108mitochondrial respiratory chain complex I assembly (GO:0032981)2.56065793
109NADH dehydrogenase complex assembly (GO:0010257)2.56065793
110mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.56065793
111synaptic vesicle docking involved in exocytosis (GO:0016081)2.55963423
112neuron migration (GO:0001764)2.54944943
113regulation of mRNA splicing, via spliceosome (GO:0048024)2.54859363
114protein polyglutamylation (GO:0018095)2.54716516
115DNA ligation (GO:0006266)2.54204619
116organelle disassembly (GO:1903008)2.52796302
117short-term memory (GO:0007614)2.52212577
118negative regulation of dendrite development (GO:2000171)2.52064450
119retinal ganglion cell axon guidance (GO:0031290)2.52047106
120epithelial cilium movement (GO:0003351)2.51441096
121cullin deneddylation (GO:0010388)2.51293544
122de novo posttranslational protein folding (GO:0051084)2.51282427
123respiratory electron transport chain (GO:0022904)2.51192476
124protein complex biogenesis (GO:0070271)2.50652699
125cerebral cortex cell migration (GO:0021795)2.50142324
126positive regulation of oligodendrocyte differentiation (GO:0048714)2.50052166
127ganglion development (GO:0061548)2.49910596
128CENP-A containing nucleosome assembly (GO:0034080)2.49736299
129regulation of synaptic transmission, glutamatergic (GO:0051966)2.49001972
130mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.48332900
131neuronal action potential propagation (GO:0019227)2.47687309
132response to auditory stimulus (GO:0010996)2.47002330
133positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.46983202
134long-chain fatty acid biosynthetic process (GO:0042759)2.46800807
135electron transport chain (GO:0022900)2.46437837
136negative regulation of transcription regulatory region DNA binding (GO:2000678)2.46162264
137generation of neurons (GO:0048699)2.45763500
138nervous system development (GO:0007399)2.45734630
139calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.45671791
140regulation of feeding behavior (GO:0060259)2.45230240
141glial cell proliferation (GO:0014009)2.43748487
142cranial nerve morphogenesis (GO:0021602)2.43629036
143membrane hyperpolarization (GO:0060081)2.43541137
144neurotransmitter uptake (GO:0001504)2.41956289
145regulation of synapse maturation (GO:0090128)2.41545162
146positive regulation of protein depolymerization (GO:1901881)2.40579514
147neurotransmitter-gated ion channel clustering (GO:0072578)2.40564115
148positive regulation of amino acid transport (GO:0051957)2.40490442
149positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.40239507
150positive regulation of synaptic transmission, GABAergic (GO:0032230)2.40107702
151regulation of synaptic vesicle transport (GO:1902803)2.40013240
152behavioral response to ethanol (GO:0048149)2.39788336
153head development (GO:0060322)2.39498167
154regulation of telomere maintenance (GO:0032204)2.39066395
155DNA damage response, detection of DNA damage (GO:0042769)2.39050301
156substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.36333963

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.67813392
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.36289330
3GBX2_23144817_ChIP-Seq_PC3_Human3.25672892
4EZH2_27304074_Chip-Seq_ESCs_Mouse2.84595144
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.71389789
6TAF15_26573619_Chip-Seq_HEK293_Human2.48922936
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.43827493
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.43385711
9CBX2_27304074_Chip-Seq_ESCs_Mouse2.40198699
10BMI1_23680149_ChIP-Seq_NPCS_Mouse2.39213717
11CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.32526214
12REST_21632747_ChIP-Seq_MESCs_Mouse2.31957317
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.23836753
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.18591473
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.18274789
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.16723175
17EZH2_18974828_ChIP-Seq_MESCs_Mouse2.10238780
18RNF2_18974828_ChIP-Seq_MESCs_Mouse2.10238780
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.10034750
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.06462159
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.05778164
22RNF2_27304074_Chip-Seq_NSC_Mouse2.02297668
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.00352817
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.99319645
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.98498901
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.97037599
27SUZ12_27294783_Chip-Seq_ESCs_Mouse1.93547818
28SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.90045316
29IGF1R_20145208_ChIP-Seq_DFB_Human1.89889184
30* REST_18959480_ChIP-ChIP_MESCs_Mouse1.89854579
31EZH2_27294783_Chip-Seq_ESCs_Mouse1.89097525
32PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.87865160
33SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.87786719
34RBPJ_22232070_ChIP-Seq_NCS_Mouse1.87236909
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87226243
36RNF2_27304074_Chip-Seq_ESCs_Mouse1.81875826
37HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.66721832
38FUS_26573619_Chip-Seq_HEK293_Human1.64822040
39POU5F1_16153702_ChIP-ChIP_HESCs_Human1.60147724
40SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.58227693
41MTF2_20144788_ChIP-Seq_MESCs_Mouse1.54694414
42ZNF274_21170338_ChIP-Seq_K562_Hela1.52399601
43RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.51844339
44P300_19829295_ChIP-Seq_ESCs_Human1.47672609
45MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.47467379
46HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.43716472
47POU3F2_20337985_ChIP-ChIP_501MEL_Human1.40496090
48AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40205594
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.35373427
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35303545
51AR_25329375_ChIP-Seq_VCAP_Human1.34041745
52EWS_26573619_Chip-Seq_HEK293_Human1.33225043
53E2F4_17652178_ChIP-ChIP_JURKAT_Human1.32893492
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32878709
55KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.31528145
56PIAS1_25552417_ChIP-Seq_VCAP_Human1.31059085
57IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30531522
58CBP_20019798_ChIP-Seq_JUKART_Human1.30531522
59IRF1_19129219_ChIP-ChIP_H3396_Human1.29336408
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28770364
61SOX2_16153702_ChIP-ChIP_HESCs_Human1.26807973
62RARB_27405468_Chip-Seq_BRAIN_Mouse1.23952311
63FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.22352245
64TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22081604
65VDR_22108803_ChIP-Seq_LS180_Human1.19714435
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.19480791
67* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.19112763
68ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.19074019
69MYC_18940864_ChIP-ChIP_HL60_Human1.18632321
70CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18570439
71RING1B_27294783_Chip-Seq_ESCs_Mouse1.17752626
72TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17665554
73TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17370344
74POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17370344
75STAT3_23295773_ChIP-Seq_U87_Human1.17271457
76AR_21572438_ChIP-Seq_LNCaP_Human1.17217984
77* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16756088
78PCGF2_27294783_Chip-Seq_ESCs_Mouse1.16669331
79NANOG_18555785_Chip-Seq_ESCs_Mouse1.16557978
80ER_23166858_ChIP-Seq_MCF-7_Human1.14981784
81KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.14652234
82ELK1_19687146_ChIP-ChIP_HELA_Human1.14464819
83TP63_19390658_ChIP-ChIP_HaCaT_Human1.13722744
84OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.13694628
85* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13614702
86RING1B_27294783_Chip-Seq_NPCs_Mouse1.13338913
87KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09333321
88TAL1_26923725_Chip-Seq_HPCs_Mouse1.09242986
89EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.08987910
90TP53_22573176_ChIP-Seq_HFKS_Human1.08888884
91E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.05533213
92PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04631696
93NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.04072733
94CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.03956460
95SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03304413
96SOX9_26525672_Chip-Seq_HEART_Mouse1.02976857
97* TCF4_23295773_ChIP-Seq_U87_Human1.02789516
98SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.01688932
99P53_22387025_ChIP-Seq_ESCs_Mouse1.00311116
100BCAT_22108803_ChIP-Seq_LS180_Human1.00249920
101FLI1_21867929_ChIP-Seq_TH2_Mouse0.99776971
102STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.99738400
103EST1_17652178_ChIP-ChIP_JURKAT_Human0.99148057
104JUN_21703547_ChIP-Seq_K562_Human0.97164863
105SMAD4_21799915_ChIP-Seq_A2780_Human0.96583118
106ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.96550929
107UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96473551
108MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.95893941
109YY1_21170310_ChIP-Seq_MESCs_Mouse0.95644541
110P53_22127205_ChIP-Seq_FIBROBLAST_Human0.94893499
111DROSHA_22980978_ChIP-Seq_HELA_Human0.94357415
112GABP_17652178_ChIP-ChIP_JURKAT_Human0.94094034
113REST_19997604_ChIP-ChIP_NEURONS_Mouse0.93664102
114SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93351304
115* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92827763
116CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.92795835
117* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.91528679
118* POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.90962848
119TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90558009
120GATA1_26923725_Chip-Seq_HPCs_Mouse0.90032219
121* SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89119522
122GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.89017477
123ERG_21242973_ChIP-ChIP_JURKAT_Human0.87916496
124* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.87225995
125SOX2_21211035_ChIP-Seq_LN229_Gbm0.86580025
126* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.86447709
127CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.86042503
128RUNX2_22187159_ChIP-Seq_PCA_Human0.84014213
129RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.83992841

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.48192622
2MP0005423_abnormal_somatic_nervous3.40911691
3MP0004859_abnormal_synaptic_plasticity3.23963612
4MP0006276_abnormal_autonomic_nervous3.21943668
5MP0000778_abnormal_nervous_system3.09894419
6MP0004270_analgesia2.99194977
7MP0001529_abnormal_vocalization2.96082480
8MP0003635_abnormal_synaptic_transmissio2.76870451
9MP0001968_abnormal_touch/_nociception2.53492786
10MP0002063_abnormal_learning/memory/cond2.49207656
11MP0002734_abnormal_mechanical_nocicepti2.42768404
12MP0002184_abnormal_innervation2.29531417
13MP0002735_abnormal_chemical_nociception2.26956248
14MP0002572_abnormal_emotion/affect_behav2.26075383
15MP0003122_maternal_imprinting2.23034397
16MP0009745_abnormal_behavioral_response2.22220473
17MP0002102_abnormal_ear_morphology2.14982529
18MP0009379_abnormal_foot_pigmentation2.10438722
19MP0001905_abnormal_dopamine_level2.10428507
20MP0002736_abnormal_nociception_after2.07292621
21MP0001486_abnormal_startle_reflex2.07204697
22MP0002064_seizures2.04829675
23MP0008789_abnormal_olfactory_epithelium1.95934609
24MP0002733_abnormal_thermal_nociception1.92372967
25MP0005645_abnormal_hypothalamus_physiol1.89797545
26MP0003787_abnormal_imprinting1.83554038
27MP0002557_abnormal_social/conspecific_i1.83538615
28MP0005499_abnormal_olfactory_system1.81899879
29MP0005394_taste/olfaction_phenotype1.81899879
30MP0001188_hyperpigmentation1.81787506
31MP0002234_abnormal_pharynx_morphology1.76074710
32MP0001970_abnormal_pain_threshold1.75418207
33* MP0002272_abnormal_nervous_system1.74579338
34MP0009046_muscle_twitch1.71869912
35MP0004811_abnormal_neuron_physiology1.71610457
36MP0002067_abnormal_sensory_capabilities1.70556088
37MP0001440_abnormal_grooming_behavior1.65083896
38MP0003121_genomic_imprinting1.65040338
39MP0004924_abnormal_behavior1.62073222
40MP0005386_behavior/neurological_phenoty1.62073222
41MP0001984_abnormal_olfaction1.59741016
42MP0002751_abnormal_autonomic_nervous1.56326346
43MP0004742_abnormal_vestibular_system1.54395805
44MP0000569_abnormal_digit_pigmentation1.54080336
45MP0000631_abnormal_neuroendocrine_gland1.53880444
46MP0002882_abnormal_neuron_morphology1.52292473
47MP0002638_abnormal_pupillary_reflex1.51287744
48MP0006292_abnormal_olfactory_placode1.48386175
49MP0000955_abnormal_spinal_cord1.47140535
50MP0005409_darkened_coat_color1.36608719
51* MP0002152_abnormal_brain_morphology1.34925186
52MP0003861_abnormal_nervous_system1.34315989
53MP0000537_abnormal_urethra_morphology1.33155230
54MP0002938_white_spotting1.32500335
55MP0005253_abnormal_eye_physiology1.32083788
56MP0005187_abnormal_penis_morphology1.31992852
57MP0003567_abnormal_fetal_cardiomyocyte1.29993541
58MP0004142_abnormal_muscle_tone1.24525365
59MP0002066_abnormal_motor_capabilities/c1.23009419
60MP0002752_abnormal_somatic_nervous1.21015062
61MP0003890_abnormal_embryonic-extraembry1.18184007
62MP0003938_abnormal_ear_development1.13569337
63MP0003315_abnormal_perineum_morphology1.13370345
64MP0005646_abnormal_pituitary_gland1.08529167
65MP0000372_irregular_coat_pigmentation1.08400016
66MP0001485_abnormal_pinna_reflex1.07899406
67MP0001963_abnormal_hearing_physiology1.05688922
68MP0000026_abnormal_inner_ear1.05099753
69MP0003937_abnormal_limbs/digits/tail_de1.04756452
70MP0001502_abnormal_circadian_rhythm1.01662329
71MP0008569_lethality_at_weaning0.98736974
72MP0010094_abnormal_chromosome_stability0.95403173
73MP0000049_abnormal_middle_ear0.95231727
74MP0004885_abnormal_endolymph0.93334674
75MP0000647_abnormal_sebaceous_gland0.92879964
76MP0000015_abnormal_ear_pigmentation0.92468379
77MP0004133_heterotaxia0.92147317
78MP0003136_yellow_coat_color0.91734987
79MP0003221_abnormal_cardiomyocyte_apopto0.91680459
80MP0006072_abnormal_retinal_apoptosis0.90528967
81MP0008877_abnormal_DNA_methylation0.89265644
82MP0003011_delayed_dark_adaptation0.88464301
83MP0003755_abnormal_palate_morphology0.87328947
84MP0002822_catalepsy0.87028361
85MP0004858_abnormal_nervous_system0.86054431
86MP0001177_atelectasis0.85971825
87MP0001299_abnormal_eye_distance/0.85058938
88MP0001286_abnormal_eye_development0.84522262
89MP0000566_synostosis0.83769656
90MP0005084_abnormal_gallbladder_morpholo0.83338753
91MP0001293_anophthalmia0.82439173
92MP0001501_abnormal_sleep_pattern0.81627633
93MP0008995_early_reproductive_senescence0.80321106
94MP0002081_perinatal_lethality0.79912456
95MP0002909_abnormal_adrenal_gland0.79872893
96MP0002210_abnormal_sex_determination0.78627355
97MP0003879_abnormal_hair_cell0.78450317
98MP0005391_vision/eye_phenotype0.77970966
99MP0001986_abnormal_taste_sensitivity0.76669753
100MP0002837_dystrophic_cardiac_calcinosis0.76195999
101MP0002069_abnormal_eating/drinking_beha0.75857158
102MP0004215_abnormal_myocardial_fiber0.75800213
103MP0001943_abnormal_respiration0.75130940
104MP0005551_abnormal_eye_electrophysiolog0.74785104
105MP0005174_abnormal_tail_pigmentation0.74214776
106MP0003385_abnormal_body_wall0.73340519
107MP0003119_abnormal_digestive_system0.73207734
108MP0003942_abnormal_urinary_system0.72936022
109MP0002653_abnormal_ependyma_morphology0.69640473
110MP0002163_abnormal_gland_morphology0.69432459
111MP0010770_preweaning_lethality0.67871078
112MP0002082_postnatal_lethality0.67871078
113MP0008058_abnormal_DNA_repair0.67259415
114MP0003698_abnormal_male_reproductive0.66754177
115MP0010386_abnormal_urinary_bladder0.65998905
116MP0003137_abnormal_impulse_conducting0.65228059
117MP0002233_abnormal_nose_morphology0.64910715
118MP0010769_abnormal_survival0.63881475
119MP0005195_abnormal_posterior_eye0.63799951
120MP0010768_mortality/aging0.62805866
121MP0004134_abnormal_chest_morphology0.62309595
122MP0002095_abnormal_skin_pigmentation0.60575616

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.46696832
2Limb dystonia (HP:0002451)4.36149796
3Acute necrotizing encephalopathy (HP:0006965)3.55854062
4Focal motor seizures (HP:0011153)3.43093778
5Cortical dysplasia (HP:0002539)3.27938932
6Hypoplasia of the brainstem (HP:0002365)3.25913632
7Aplasia/Hypoplasia of the brainstem (HP:0007362)3.25913632
8Lissencephaly (HP:0001339)3.15884810
9Volvulus (HP:0002580)3.14125598
10Abnormality of the labia minora (HP:0012880)3.13155997
11Abnormal hair whorl (HP:0010721)3.07422700
12Progressive macrocephaly (HP:0004481)3.06935918
13Abnormal mitochondria in muscle tissue (HP:0008316)3.04754633
14Polyphagia (HP:0002591)3.04610399
15True hermaphroditism (HP:0010459)3.01128614
16Amblyopia (HP:0000646)3.00287630
17Abnormality of midbrain morphology (HP:0002418)2.87733437
18Molar tooth sign on MRI (HP:0002419)2.87733437
19Focal seizures (HP:0007359)2.87384243
20Epileptic encephalopathy (HP:0200134)2.85322526
21Retinal dysplasia (HP:0007973)2.84165189
22Pancreatic cysts (HP:0001737)2.81565859
23Gait imbalance (HP:0002141)2.81259296
24Increased serum pyruvate (HP:0003542)2.80978623
25Abnormality of glycolysis (HP:0004366)2.80978623
26Broad-based gait (HP:0002136)2.79041331
27Mitochondrial inheritance (HP:0001427)2.76739359
28Pancreatic fibrosis (HP:0100732)2.74363231
29Ankle clonus (HP:0011448)2.72087566
30Nephronophthisis (HP:0000090)2.66662136
31Amyotrophic lateral sclerosis (HP:0007354)2.66154603
32Abnormality of the corticospinal tract (HP:0002492)2.60665448
33Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.50089691
34Degeneration of the lateral corticospinal tracts (HP:0002314)2.50089691
35Failure to thrive in infancy (HP:0001531)2.49661975
36Progressive cerebellar ataxia (HP:0002073)2.49063900
37Acute encephalopathy (HP:0006846)2.47392142
38Absent speech (HP:0001344)2.43999564
39Protruding tongue (HP:0010808)2.43746072
40Intestinal atresia (HP:0011100)2.38649958
41Hyperventilation (HP:0002883)2.36011808
42Febrile seizures (HP:0002373)2.35412344
43Atonic seizures (HP:0010819)2.35344808
44Medial flaring of the eyebrow (HP:0010747)2.35226837
45Oligodactyly (hands) (HP:0001180)2.33561344
46Esotropia (HP:0000565)2.33088409
47Specific learning disability (HP:0001328)2.30547918
48Exotropia (HP:0000577)2.24516040
49Visual hallucinations (HP:0002367)2.23430891
50Sleep apnea (HP:0010535)2.23357395
51Leukodystrophy (HP:0002415)2.22985405
52Drooling (HP:0002307)2.16775777
53Excessive salivation (HP:0003781)2.16775777
54Shoulder girdle muscle weakness (HP:0003547)2.16674898
55Poor suck (HP:0002033)2.16454767
56Termporal pattern (HP:0011008)2.15567010
57Insidious onset (HP:0003587)2.15567010
58Mutism (HP:0002300)2.15292368
59Increased CSF lactate (HP:0002490)2.13768998
60Urinary urgency (HP:0000012)2.13650242
61Nephrogenic diabetes insipidus (HP:0009806)2.09329937
62Congenital primary aphakia (HP:0007707)2.07514659
63Pheochromocytoma (HP:0002666)2.07500923
64Aplasia/Hypoplasia of the patella (HP:0006498)2.05822915
65Increased hepatocellular lipid droplets (HP:0006565)2.05195883
66Colon cancer (HP:0003003)2.04405930
67Narrow forehead (HP:0000341)2.03715921
68Spastic gait (HP:0002064)2.03250600
69Abnormality of the renal medulla (HP:0100957)2.02638894
70Heterochromia iridis (HP:0001100)2.02271605
71Postaxial hand polydactyly (HP:0001162)2.01002375
72Optic disc pallor (HP:0000543)2.00084732
73Vaginal atresia (HP:0000148)1.99793037
74Progressive inability to walk (HP:0002505)1.99711802
75Spastic tetraplegia (HP:0002510)1.98566405
76Genital tract atresia (HP:0001827)1.98498239
77Hypothermia (HP:0002045)1.97972313
78Neuroendocrine neoplasm (HP:0100634)1.97419829
79Anencephaly (HP:0002323)1.95861624
80Optic nerve hypoplasia (HP:0000609)1.95069917
81Poor coordination (HP:0002370)1.93373584
82Impaired vibration sensation in the lower limbs (HP:0002166)1.93088598
83Cerebral hypomyelination (HP:0006808)1.92553019
84Pachygyria (HP:0001302)1.92037587
85Abnormal eating behavior (HP:0100738)1.90796898
86Sclerocornea (HP:0000647)1.90398859
87Split foot (HP:0001839)1.90099332
88Micropenis (HP:0000054)1.89550089
89Morphological abnormality of the middle ear (HP:0008609)1.88900797
90Absence seizures (HP:0002121)1.87985755
91Renal cortical cysts (HP:0000803)1.87133348
92Pendular nystagmus (HP:0012043)1.87010881
93Hepatocellular necrosis (HP:0001404)1.86317437
94High anterior hairline (HP:0009890)1.85044318
95Decreased testicular size (HP:0008734)1.84907043
96Postaxial foot polydactyly (HP:0001830)1.84562196
97Aplasia/Hypoplasia of the uvula (HP:0010293)1.84308770
98Inability to walk (HP:0002540)1.84222870
99Growth hormone deficiency (HP:0000824)1.82737181
100Hepatoblastoma (HP:0002884)1.82662293
101Type II lissencephaly (HP:0007260)1.81219167
102Abnormality of cells of the erythroid lineage (HP:0012130)1.79755551
103Renal Fanconi syndrome (HP:0001994)1.79644669
104Narrow nasal bridge (HP:0000446)1.78155226
105Sensory axonal neuropathy (HP:0003390)1.77920664
106Atrophy/Degeneration involving motor neurons (HP:0007373)1.77064350
107Aplasia/Hypoplasia of the tongue (HP:0010295)1.77042726
108Akinesia (HP:0002304)1.76883633
109Rimmed vacuoles (HP:0003805)1.76772307
110Abnormality of the musculature of the pelvis (HP:0001469)1.76147910
111Abnormality of the hip-girdle musculature (HP:0001445)1.76147910
112Poor eye contact (HP:0000817)1.75305539
113Meckel diverticulum (HP:0002245)1.75257006
114Papilledema (HP:0001085)1.75167786
115Abnormality of the ileum (HP:0001549)1.74676706
116Aplasia/Hypoplasia of the tibia (HP:0005772)1.74358785
117Truncal ataxia (HP:0002078)1.74331058
118Broad foot (HP:0001769)1.74268299
119Dialeptic seizures (HP:0011146)1.74178289
120Intellectual disability, moderate (HP:0002342)1.74119689
121Scrotal hypoplasia (HP:0000046)1.72781788
122Epileptiform EEG discharges (HP:0011182)1.72506254
123Abnormal lung lobation (HP:0002101)1.71880707
124Wrist flexion contracture (HP:0001239)1.71246195
125Morphological abnormality of the pyramidal tract (HP:0002062)1.70082430
126Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.69962682
127EEG with generalized epileptiform discharges (HP:0011198)1.69574332
128Renal hypoplasia (HP:0000089)1.69354767
129Aplasia/Hypoplasia of the sternum (HP:0006714)1.68978246
130Autism (HP:0000717)1.68332175
131Aganglionic megacolon (HP:0002251)1.68290714
132Agitation (HP:0000713)1.68250920
133Tented upper lip vermilion (HP:0010804)1.67485136
134Sacral dimple (HP:0000960)1.66993080
135Hypsarrhythmia (HP:0002521)1.66862110
136Oligodactyly (HP:0012165)1.66676233
137Preaxial hand polydactyly (HP:0001177)1.66367503
138Medulloblastoma (HP:0002885)1.66125927
139Supranuclear gaze palsy (HP:0000605)1.66070615
140Patellar aplasia (HP:0006443)1.65613688
141Abnormality of salivation (HP:0100755)1.65566830
142Generalized tonic-clonic seizures (HP:0002069)1.63618951
143Inappropriate behavior (HP:0000719)1.61040686
144Nasal speech (HP:0001611)1.60358186
145Hyperthyroidism (HP:0000836)1.60152925
146Sporadic (HP:0003745)1.58356684
147Generalized hypotonia (HP:0001290)1.56474873
1483-Methylglutaconic aciduria (HP:0003535)1.56064706
149Abnormal number of erythroid precursors (HP:0012131)1.54744860
150Gastroesophageal reflux (HP:0002020)1.54631907

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.90012319
2CASK3.67023873
3DYRK23.31696881
4TRIM282.85918758
5MAP4K22.85463644
6NTRK22.75376873
7NEK12.64707159
8MAP2K72.53976948
9MAP3K122.47736025
10MAP3K42.24817716
11CDK192.11519545
12CCNB11.97988107
13MINK11.94240444
14PNCK1.93038400
15LIMK11.86670465
16BMPR1B1.86644505
17WEE11.85132499
18NTRK31.80935969
19TNIK1.80680519
20STK161.79298859
21BCR1.76879310
22* MAPK131.74124327
23SIK21.73734685
24CSNK1G31.71944493
25ERBB31.67079214
26SRPK11.66104517
27SIK31.63900676
28DAPK21.52894882
29CSNK1G21.46105526
30MAP3K91.45790324
31NME11.45260151
32DAPK11.44110486
33PLK41.42873436
34VRK11.27197308
35WNK31.26582216
36EPHA41.26319654
37PLK21.25322724
38CSNK1A1L1.21362616
39GRK51.21292824
40DYRK31.20188956
41BUB11.20158370
42OXSR11.19167261
43KSR11.19048499
44PINK11.17707391
45DYRK1A1.16638501
46FRK1.11864450
47PHKG21.09483205
48PHKG11.09483205
49MKNK11.09188354
50ZAK1.09013174
51CSNK1G11.07764673
52PAK31.00677364
53PKN11.00605279
54* CDK50.98034099
55MAP2K40.97482791
56NUAK10.96023628
57NEK20.92742954
58YES10.90590773
59RPS6KA40.88046752
60INSRR0.86207648
61PRPF4B0.86003183
62PAK60.85432858
63* CDK180.82925600
64CDC70.82449154
65FGFR20.81863788
66MAPKAPK50.79808216
67MAP3K60.79386445
68ADRBK10.77406116
69EPHB20.77214178
70SGK2230.77169263
71SGK4940.77169263
72CDK80.76871551
73* CDK140.75066602
74* CDK150.73003611
75PLK30.72323465
76ADRBK20.70099801
77TESK20.69359740
78PLK10.67630928
79* CDK11A0.66710361
80PRKCG0.66451666
81TSSK60.66043234
82ACVR1B0.65035404
83TGFBR10.64939035
84GRK10.61045916
85VRK20.60787840
86MARK20.58997536
87RPS6KA20.58581473
88GRK70.58427768
89TYRO30.56897821
90BCKDK0.56851549
91CAMKK20.56736113
92STK390.54293813
93ROCK20.53568173
94BRSK10.50490033
95AURKA0.50457064
96STK38L0.49212699
97PRKD30.48604273
98BRSK20.48121981
99FGR0.47979051
100* CAMK2A0.47621136
101EPHA30.47327143
102* UHMK10.46773022
103ILK0.46761156
104BRAF0.46645426
105ATR0.45253947
106CSNK1D0.44928871
107CSNK1A10.42739104
108TAOK10.42443619
109DAPK30.40685348
110* PRKACA0.40562939
111TTK0.40222396
112ARAF0.40009865
113MKNK20.39705481
114DYRK1B0.38813663
115* MAPK90.38002142
116* CAMK2B0.37354489
117ATM0.37058870
118MAPK120.36665357
119MAPK150.36139058
120PRKCZ0.35809439
121CHEK20.35527657
122STK110.34761211
123ERBB20.34487756
124AURKB0.34006036
125PRKCE0.31026095
126SGK20.30440070
127* CDK10.30221670
128CDK30.29614892
129CSNK1E0.27788253
130* MAPK40.27624275
131PRKG10.27126734
132TLK10.26855904
133TESK10.26700075

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.40790150
2Parkinsons disease_Homo sapiens_hsa050123.24769706
3Nicotine addiction_Homo sapiens_hsa050333.23022573
4Synaptic vesicle cycle_Homo sapiens_hsa047212.49347898
5Alzheimers disease_Homo sapiens_hsa050102.46630949
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.35492471
7Huntingtons disease_Homo sapiens_hsa050162.33560250
8Ribosome_Homo sapiens_hsa030102.23656680
9Proteasome_Homo sapiens_hsa030502.22405469
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.22340159
11Axon guidance_Homo sapiens_hsa043602.04467145
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.03080018
13Spliceosome_Homo sapiens_hsa030401.84387630
14Glutamatergic synapse_Homo sapiens_hsa047241.81803698
15Butanoate metabolism_Homo sapiens_hsa006501.81264581
16Dopaminergic synapse_Homo sapiens_hsa047281.79699523
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.79021533
18Serotonergic synapse_Homo sapiens_hsa047261.77345049
19GABAergic synapse_Homo sapiens_hsa047271.76171346
20Morphine addiction_Homo sapiens_hsa050321.73585127
21Olfactory transduction_Homo sapiens_hsa047401.69372484
22Cardiac muscle contraction_Homo sapiens_hsa042601.67943936
23Circadian entrainment_Homo sapiens_hsa047131.64090352
24Collecting duct acid secretion_Homo sapiens_hsa049661.62548756
25Taste transduction_Homo sapiens_hsa047421.60734119
26RNA polymerase_Homo sapiens_hsa030201.58099994
27Mismatch repair_Homo sapiens_hsa034301.57546511
28DNA replication_Homo sapiens_hsa030301.52012713
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.46459997
30Amphetamine addiction_Homo sapiens_hsa050311.46156673
31Cocaine addiction_Homo sapiens_hsa050301.42689278
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.37196230
33Propanoate metabolism_Homo sapiens_hsa006401.35485393
34Alcoholism_Homo sapiens_hsa050341.33550446
35Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.30894719
36Phototransduction_Homo sapiens_hsa047441.30751687
37Gap junction_Homo sapiens_hsa045401.30664885
38Cholinergic synapse_Homo sapiens_hsa047251.30043888
39Long-term potentiation_Homo sapiens_hsa047201.29075705
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.19094203
41Long-term depression_Homo sapiens_hsa047301.18093313
42Vibrio cholerae infection_Homo sapiens_hsa051101.16451196
43Oocyte meiosis_Homo sapiens_hsa041141.13422594
44Nucleotide excision repair_Homo sapiens_hsa034201.08354332
45mRNA surveillance pathway_Homo sapiens_hsa030151.08308192
46Colorectal cancer_Homo sapiens_hsa052101.05261434
47Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.04402576
48Base excision repair_Homo sapiens_hsa034100.99192197
49Pyrimidine metabolism_Homo sapiens_hsa002400.95556384
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.94703598
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94201411
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90241592
53Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.89065894
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.88998014
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86143012
56Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.85179914
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.84249843
58Renin secretion_Homo sapiens_hsa049240.82375359
59Linoleic acid metabolism_Homo sapiens_hsa005910.81449328
60ErbB signaling pathway_Homo sapiens_hsa040120.80731510
61Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79336914
62Oxytocin signaling pathway_Homo sapiens_hsa049210.78763855
63Insulin secretion_Homo sapiens_hsa049110.78157842
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.77856475
65Cell cycle_Homo sapiens_hsa041100.77626576
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.77062742
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75414742
68Homologous recombination_Homo sapiens_hsa034400.75036846
69Basal transcription factors_Homo sapiens_hsa030220.74368375
70Phagosome_Homo sapiens_hsa041450.73969305
71Fanconi anemia pathway_Homo sapiens_hsa034600.73441924
72RNA transport_Homo sapiens_hsa030130.71304609
73Wnt signaling pathway_Homo sapiens_hsa043100.70213256
74Gastric acid secretion_Homo sapiens_hsa049710.69233331
75Protein export_Homo sapiens_hsa030600.68841946
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68706115
77Fatty acid elongation_Homo sapiens_hsa000620.68259939
78Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.67786803
79Steroid biosynthesis_Homo sapiens_hsa001000.67635582
80Tryptophan metabolism_Homo sapiens_hsa003800.66665317
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.65667953
82Calcium signaling pathway_Homo sapiens_hsa040200.64752414
83RNA degradation_Homo sapiens_hsa030180.64673840
84Melanogenesis_Homo sapiens_hsa049160.64214427
85Salivary secretion_Homo sapiens_hsa049700.63900769
86Hedgehog signaling pathway_Homo sapiens_hsa043400.63547602
87GnRH signaling pathway_Homo sapiens_hsa049120.62347839
88Aldosterone synthesis and secretion_Homo sapiens_hsa049250.60624046
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59981364
90Purine metabolism_Homo sapiens_hsa002300.59606120
91Regulation of autophagy_Homo sapiens_hsa041400.58077174
92Pyruvate metabolism_Homo sapiens_hsa006200.57598941
93beta-Alanine metabolism_Homo sapiens_hsa004100.56830236
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56398309
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55701434
96Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53590490
97Glioma_Homo sapiens_hsa052140.52496697
98Endometrial cancer_Homo sapiens_hsa052130.52445845
99Renal cell carcinoma_Homo sapiens_hsa052110.52269357
100Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51936389
101Hippo signaling pathway_Homo sapiens_hsa043900.50630372
102Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49868264
103Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46443706
104Ether lipid metabolism_Homo sapiens_hsa005650.46301237
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.46278588
106Basal cell carcinoma_Homo sapiens_hsa052170.45586122
107Systemic lupus erythematosus_Homo sapiens_hsa053220.44460886
108Folate biosynthesis_Homo sapiens_hsa007900.44059537
109Peroxisome_Homo sapiens_hsa041460.43698977
110Metabolic pathways_Homo sapiens_hsa011000.43488921
111Ras signaling pathway_Homo sapiens_hsa040140.43320773
112Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40079741
113Selenocompound metabolism_Homo sapiens_hsa004500.39175935
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.39123318
115Nitrogen metabolism_Homo sapiens_hsa009100.38994852
116Estrogen signaling pathway_Homo sapiens_hsa049150.37679640
117Fatty acid metabolism_Homo sapiens_hsa012120.37316817
118Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35860813
119Epstein-Barr virus infection_Homo sapiens_hsa051690.35488533
120Primary bile acid biosynthesis_Homo sapiens_hsa001200.35212898
121* MAPK signaling pathway_Homo sapiens_hsa040100.34747881
122Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.33416328
123Vitamin B6 metabolism_Homo sapiens_hsa007500.32634892
124Cysteine and methionine metabolism_Homo sapiens_hsa002700.32355814
125Non-homologous end-joining_Homo sapiens_hsa034500.32276263
126Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.31440639
127cAMP signaling pathway_Homo sapiens_hsa040240.30617910
128Sphingolipid signaling pathway_Homo sapiens_hsa040710.30486357
129Viral myocarditis_Homo sapiens_hsa054160.27767356
130Non-small cell lung cancer_Homo sapiens_hsa052230.27264669
131N-Glycan biosynthesis_Homo sapiens_hsa005100.24859617

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