STK32B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a serine-threonine protein kinase. Serine-threonine kinases transfer phosphate molecules to the oxygen atoms of serine and threonine. A genomic deletion affecting this gene has been associated with Ellis-van Creveld syndrome, an autosomal recessive skeletal dysplasia. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)8.02961009
2nucleobase catabolic process (GO:0046113)6.03068317
3cell migration in hindbrain (GO:0021535)5.46107711
4neuron cell-cell adhesion (GO:0007158)5.42513122
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.28296566
6neuron fate determination (GO:0048664)4.89541478
7layer formation in cerebral cortex (GO:0021819)4.58033163
8neuron recognition (GO:0008038)4.55442992
9dendritic spine morphogenesis (GO:0060997)4.49783506
10vocalization behavior (GO:0071625)4.44511859
11central nervous system projection neuron axonogenesis (GO:0021952)4.42753012
12regulation of penile erection (GO:0060405)4.40552229
13regulation of respiratory gaseous exchange by neurological system process (GO:0002087)4.26556100
14axonal fasciculation (GO:0007413)4.25776916
15regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.22772624
16response to pheromone (GO:0019236)4.18858258
17gamma-aminobutyric acid transport (GO:0015812)4.17215397
18negative regulation of microtubule polymerization (GO:0031115)4.12747762
19protein localization to synapse (GO:0035418)4.11429763
20regulation of short-term neuronal synaptic plasticity (GO:0048172)4.09010568
21synaptic vesicle exocytosis (GO:0016079)4.06967074
22dendrite morphogenesis (GO:0048813)3.94929338
23righting reflex (GO:0060013)3.92052759
24synaptic vesicle maturation (GO:0016188)3.88999686
25negative regulation of synaptic transmission, GABAergic (GO:0032229)3.87732532
26regulation of glutamate receptor signaling pathway (GO:1900449)3.87448499
27axon extension (GO:0048675)3.84635308
28postsynaptic membrane organization (GO:0001941)3.82387982
29regulation of synaptic vesicle exocytosis (GO:2000300)3.78298952
30exploration behavior (GO:0035640)3.78174944
31protein heterotrimerization (GO:0070208)3.73780373
32negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.68890206
33glycine transport (GO:0015816)3.65830619
34collagen fibril organization (GO:0030199)3.64386072
35regulation of respiratory system process (GO:0044065)3.64316710
36regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.62157254
37serotonin metabolic process (GO:0042428)3.59304893
38regulation of synaptic vesicle transport (GO:1902803)3.55324616
39positive regulation of synapse assembly (GO:0051965)3.54982553
40induction of positive chemotaxis (GO:0050930)3.50039008
41positive regulation of mitochondrial fission (GO:0090141)3.50001792
42microtubule severing (GO:0051013)3.47514851
43glomerular basement membrane development (GO:0032836)3.47354331
44cerebral cortex radially oriented cell migration (GO:0021799)3.44622334
45ionotropic glutamate receptor signaling pathway (GO:0035235)3.43290694
46hippocampus development (GO:0021766)3.42866259
47mesenchymal-epithelial cell signaling (GO:0060638)3.42501737
48positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.41686990
49neuron projection extension (GO:1990138)3.31122353
50regulation of retinoic acid receptor signaling pathway (GO:0048385)3.30696070
51regulation of synapse structural plasticity (GO:0051823)3.28402906
52negative regulation of nitric-oxide synthase activity (GO:0051001)3.28055494
53cAMP catabolic process (GO:0006198)3.26778749
54central nervous system neuron axonogenesis (GO:0021955)3.26355965
55neuron remodeling (GO:0016322)3.24661231
56locomotory exploration behavior (GO:0035641)3.24092546
57startle response (GO:0001964)3.22304685
58dendrite development (GO:0016358)3.19959393
59neurotransmitter secretion (GO:0007269)3.19359260
60regulation of vesicle fusion (GO:0031338)3.18533893
61establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.17687927
62mitochondrion transport along microtubule (GO:0047497)3.17687927
63establishment of mitochondrion localization (GO:0051654)3.17350936
64generation of neurons (GO:0048699)3.16870539
65regulation of cAMP-dependent protein kinase activity (GO:2000479)3.14047966
66auditory behavior (GO:0031223)3.13462658
67regulation of female gonad development (GO:2000194)3.08668051
68piRNA metabolic process (GO:0034587)3.08654902
69glycosphingolipid biosynthetic process (GO:0006688)3.07527641
70proline transport (GO:0015824)3.03290914
71cerebellum development (GO:0021549)3.02736742
72synaptic transmission, glutamatergic (GO:0035249)3.02426631
73cell migration involved in heart development (GO:0060973)3.02408201
74glutamate secretion (GO:0014047)3.02016574
75cyclic nucleotide catabolic process (GO:0009214)3.01843475
76regulation of synapse assembly (GO:0051963)3.01315636
77regulation of respiratory gaseous exchange (GO:0043576)3.00579934
78dopamine receptor signaling pathway (GO:0007212)2.99567891
79regulation of acrosome reaction (GO:0060046)2.97092904
80adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.95685480
81regulation of microtubule polymerization (GO:0031113)2.95566268
82epithelial cell differentiation involved in kidney development (GO:0035850)2.94399341
83regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.93054602
84regulation of calcium ion-dependent exocytosis (GO:0017158)2.92619855
85neuron migration (GO:0001764)2.92568388
86presynaptic membrane assembly (GO:0097105)2.91947919
87negative regulation of mast cell activation (GO:0033004)2.91659493
88retinal ganglion cell axon guidance (GO:0031290)2.89120448
89cerebellar Purkinje cell differentiation (GO:0021702)2.88797091
90positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.88792637
91substrate-dependent cell migration (GO:0006929)2.88260455
92clathrin coat assembly (GO:0048268)2.87683355
93cochlea development (GO:0090102)2.87525855
94glutamate receptor signaling pathway (GO:0007215)2.86123869
95spermatid nucleus differentiation (GO:0007289)2.84921353
96cellular response to prostaglandin stimulus (GO:0071379)2.84884993
97positive regulation of filopodium assembly (GO:0051491)2.83579253
98primary amino compound metabolic process (GO:1901160)2.82016557
99growth hormone secretion (GO:0030252)2.80586901
100neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.78995150
101cranial nerve morphogenesis (GO:0021602)2.78487208
102synapse assembly (GO:0007416)2.78341667
103innervation (GO:0060384)2.77918167
104neurotransmitter-gated ion channel clustering (GO:0072578)2.77287631
105synaptic vesicle docking involved in exocytosis (GO:0016081)2.76954796
106limb bud formation (GO:0060174)2.75500676
107negative regulation of axon guidance (GO:1902668)2.72729452
108presynaptic membrane organization (GO:0097090)2.72606861
109glycerophospholipid catabolic process (GO:0046475)2.72100511
110regulation of synapse organization (GO:0050807)2.71800875
111regulation of axon guidance (GO:1902667)2.71608557
112regulation of axon extension (GO:0030516)2.71602342
113protein-cofactor linkage (GO:0018065)2.71474155
114cAMP-mediated signaling (GO:0019933)2.71348317
115response to auditory stimulus (GO:0010996)2.71289606
116dendritic spine organization (GO:0097061)2.70870222
117endodermal cell differentiation (GO:0035987)2.69670790
118eosinophil chemotaxis (GO:0048245)2.69435907
119positive regulation of synaptic transmission, GABAergic (GO:0032230)2.68955999
120positive regulation of protein depolymerization (GO:1901881)2.68839395
121regulation of neuronal synaptic plasticity (GO:0048168)2.68635965
122neuron-neuron synaptic transmission (GO:0007270)2.67050790
123regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.66140401
124cell adhesion mediated by integrin (GO:0033627)2.64612642
125opioid receptor signaling pathway (GO:0038003)2.63417380
126neurotransmitter transport (GO:0006836)2.62625275
127developmental cell growth (GO:0048588)2.62378755
128microtubule depolymerization (GO:0007019)2.61628878
129central nervous system neuron development (GO:0021954)2.61618576
130axonogenesis (GO:0007409)2.61046170
131regulation of feeding behavior (GO:0060259)2.60483702
132regulation of axon extension involved in axon guidance (GO:0048841)2.60252825
133chaperone-mediated protein transport (GO:0072321)2.60051595
134intraspecies interaction between organisms (GO:0051703)2.59967708
135retinal cone cell development (GO:0046549)2.58216849
136type B pancreatic cell proliferation (GO:0044342)2.57825922
137collagen catabolic process (GO:0030574)2.57198023
138heparan sulfate proteoglycan metabolic process (GO:0030201)2.54641113
139collagen metabolic process (GO:0032963)2.54076552
140dermatan sulfate biosynthetic process (GO:0030208)2.53633397
141neuronal ion channel clustering (GO:0045161)2.52937022
142blood vessel maturation (GO:0001955)2.51740104
143organ formation (GO:0048645)2.46111568
144ganglion development (GO:0061548)2.44814999
145venous blood vessel morphogenesis (GO:0048845)2.43949142
146eosinophil migration (GO:0072677)2.43530021
147G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.42240298
148regulation of meiosis I (GO:0060631)2.39225202
149ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.38581186
150dermatan sulfate metabolic process (GO:0030205)2.37740387
151calcium ion-dependent exocytosis (GO:0017156)2.37637242
152chondroitin sulfate biosynthetic process (GO:0030206)2.37096948
153negative regulation of cAMP-mediated signaling (GO:0043951)2.37086869
154organelle transport along microtubule (GO:0072384)2.36543352
155maternal behavior (GO:0042711)2.34286520
156positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.34236997
157calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.34071991
158regulation of action potential (GO:0098900)2.32501248
159multicellular organismal macromolecule metabolic process (GO:0044259)2.32327344
160negative regulation of reproductive process (GO:2000242)2.30076479
161camera-type eye morphogenesis (GO:0048593)2.30001176
162multicellular organismal catabolic process (GO:0044243)2.28528424

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.45340001
2GBX2_23144817_ChIP-Seq_PC3_Human3.65613656
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.37015276
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.87779062
5EZH2_27304074_Chip-Seq_ESCs_Mouse2.83095148
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.81110858
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.80289644
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.66152986
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.62841694
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.58979038
11* REST_21632747_ChIP-Seq_MESCs_Mouse2.45247429
12IGF1R_20145208_ChIP-Seq_DFB_Human2.43638599
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.41149920
14CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.40976936
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.40092257
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.39348153
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.39348153
18PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.37961266
19SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.34092050
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.23457798
21HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.22238254
22CBX2_27304074_Chip-Seq_ESCs_Mouse2.17148169
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.14556703
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.14139025
25* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.12708226
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.10131708
27* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.07144973
28BMI1_23680149_ChIP-Seq_NPCS_Mouse2.05668820
29CTBP2_25329375_ChIP-Seq_LNCAP_Human2.05602949
30REST_18959480_ChIP-ChIP_MESCs_Mouse2.05085539
31RNF2_27304074_Chip-Seq_NSC_Mouse2.01645723
32RNF2_27304074_Chip-Seq_ESCs_Mouse2.00556542
33EED_16625203_ChIP-ChIP_MESCs_Mouse1.98796137
34MTF2_20144788_ChIP-Seq_MESCs_Mouse1.96258582
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.91173612
36WT1_19549856_ChIP-ChIP_CCG9911_Human1.88792535
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.82404167
38ZNF274_21170338_ChIP-Seq_K562_Hela1.82225627
39ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.75983896
40RBPJ_22232070_ChIP-Seq_NCS_Mouse1.74777154
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72303642
42* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65616669
43TP53_18474530_ChIP-ChIP_U2OS_Human1.59374824
44EP300_21415370_ChIP-Seq_HL-1_Mouse1.58266012
45PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.58041014
46CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.57965318
47AR_21572438_ChIP-Seq_LNCaP_Human1.56225763
48CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54254004
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53075311
50DROSHA_22980978_ChIP-Seq_HELA_Human1.52700154
51RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.52302336
52SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49122641
53P300_19829295_ChIP-Seq_ESCs_Human1.48967876
54* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43688395
55* SMAD4_21799915_ChIP-Seq_A2780_Human1.41961401
56POU3F2_20337985_ChIP-ChIP_501MEL_Human1.39411025
57TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37477521
58POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.37477521
59TAF15_26573619_Chip-Seq_HEK293_Human1.37312315
60RING1B_27294783_Chip-Seq_ESCs_Mouse1.36902354
61RARB_27405468_Chip-Seq_BRAIN_Mouse1.33661605
62EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33410961
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32037753
64* SOX2_21211035_ChIP-Seq_LN229_Gbm1.30183739
65BRD4_25478319_ChIP-Seq_HGPS_Human1.28805858
66CJUN_26792858_Chip-Seq_BT549_Human1.28437977
67TCF4_18268006_ChIP-ChIP_LS174T_Human1.27781632
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26995146
69NRF2_20460467_ChIP-Seq_MEFs_Mouse1.26579018
70NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.26579018
71KDM2B_26808549_Chip-Seq_REH_Human1.25277902
72EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.24597249
73NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23086750
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.21935332
75SALL1_21062744_ChIP-ChIP_HESCs_Human1.21691793
76RING1B_27294783_Chip-Seq_NPCs_Mouse1.20707183
77MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19345611
78AR_25329375_ChIP-Seq_VCAP_Human1.19071423
79OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.17976168
80TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.17576537
81EWS_26573619_Chip-Seq_HEK293_Human1.17131249
82* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16857268
83STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.16796009
84ELK4_26923725_Chip-Seq_MESODERM_Mouse1.16563431
85FUS_26573619_Chip-Seq_HEK293_Human1.15720990
86STAT6_21828071_ChIP-Seq_BEAS2B_Human1.14744826
87PIAS1_25552417_ChIP-Seq_VCAP_Human1.14572910
88CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.14429603
89OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14405305
90FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.13331156
91* AR_19668381_ChIP-Seq_PC3_Human1.12735494
92VDR_22108803_ChIP-Seq_LS180_Human1.12151472
93AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11809438
94CDX2_19796622_ChIP-Seq_MESCs_Mouse1.10608861
95* STAT3_23295773_ChIP-Seq_U87_Human1.10360045
96PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10312317
97YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10253823
98* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.09427747
99* TCF4_23295773_ChIP-Seq_U87_Human1.08653356
100IKZF1_21737484_ChIP-ChIP_HCT116_Human1.08555900
101TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07980465
102* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.07557275
103CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.07440389
104* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.07434245
105MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07279831
106RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.05683911
107PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04848243
108RUNX2_22187159_ChIP-Seq_PCA_Human1.04679014
109NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02985989
110TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02782165
111TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02711015
112UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02253957
113ER_23166858_ChIP-Seq_MCF-7_Human1.01958683
114KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01885792
115MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.01805846
116SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01631654
117POU5F1_16153702_ChIP-ChIP_HESCs_Human1.01416893
118TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98600854
119P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98522576
120ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97162586
121HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.96379628
122ZFP281_18757296_ChIP-ChIP_E14_Mouse0.96044134
123JUN_21703547_ChIP-Seq_K562_Human0.95995625
124* NANOG_18555785_Chip-Seq_ESCs_Mouse0.95565421
125TP63_19390658_ChIP-ChIP_HaCaT_Human0.95256207
126SMAD3_21741376_ChIP-Seq_ESCs_Human0.95077805
127TP53_20018659_ChIP-ChIP_R1E_Mouse0.94827168
128SMAD4_21741376_ChIP-Seq_HESCs_Human0.94816121
129GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94153409

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.47226646
2MP0004859_abnormal_synaptic_plasticity4.08453777
3MP0005423_abnormal_somatic_nervous3.83488881
4MP0005503_abnormal_tendon_morphology3.66424413
5MP0006276_abnormal_autonomic_nervous3.60927951
6MP0002822_catalepsy3.33914971
7MP0003880_abnormal_central_pattern3.28545284
8MP0005257_abnormal_intraocular_pressure3.03738246
9MP0003122_maternal_imprinting3.01815038
10MP0004270_analgesia2.99246510
11MP0003635_abnormal_synaptic_transmissio2.92921501
12MP0000778_abnormal_nervous_system2.91478320
13MP0000013_abnormal_adipose_tissue2.80191794
14MP0003787_abnormal_imprinting2.70236126
15MP0003279_aneurysm2.68493354
16MP0005623_abnormal_meninges_morphology2.68025046
17MP0002063_abnormal_learning/memory/cond2.55220913
18MP0000569_abnormal_digit_pigmentation2.45029768
19MP0002184_abnormal_innervation2.37881246
20MP0010368_abnormal_lymphatic_system2.36763868
21MP0004272_abnormal_basement_membrane2.31336518
22MP0002734_abnormal_mechanical_nocicepti2.29195808
23MP0005275_abnormal_skin_tensile2.28065967
24MP0002102_abnormal_ear_morphology2.23632501
25MP0002572_abnormal_emotion/affect_behav2.16230444
26MP0001529_abnormal_vocalization2.15787638
27MP0005645_abnormal_hypothalamus_physiol2.14231501
28MP0001958_emphysema1.92932230
29MP0002733_abnormal_thermal_nociception1.91475222
30MP0009745_abnormal_behavioral_response1.91326189
31MP0003121_genomic_imprinting1.89308879
32MP0010386_abnormal_urinary_bladder1.88837819
33MP0009046_muscle_twitch1.85626122
34MP0000631_abnormal_neuroendocrine_gland1.80811673
35MP0001486_abnormal_startle_reflex1.79859706
36MP0002557_abnormal_social/conspecific_i1.79569460
37MP0001968_abnormal_touch/_nociception1.79540370
38MP0009384_cardiac_valve_regurgitation1.78342282
39MP0005646_abnormal_pituitary_gland1.77852598
40MP0002064_seizures1.72696714
41MP0001542_abnormal_bone_strength1.71397106
42MP0004924_abnormal_behavior1.64477271
43MP0005386_behavior/neurological_phenoty1.64477271
44MP0000955_abnormal_spinal_cord1.63925350
45MP0004811_abnormal_neuron_physiology1.57492376
46MP0002735_abnormal_chemical_nociception1.57162109
47MP0001905_abnormal_dopamine_level1.56931671
48MP0001879_abnormal_lymphatic_vessel1.56190808
49MP0001270_distended_abdomen1.55086303
50MP0009780_abnormal_chondrocyte_physiolo1.51309554
51MP0001970_abnormal_pain_threshold1.49922741
52MP0001501_abnormal_sleep_pattern1.48921603
53MP0000538_abnormal_urinary_bladder1.46796911
54MP0002882_abnormal_neuron_morphology1.44811618
55MP0009250_abnormal_appendicular_skeleto1.42905370
56MP0000733_abnormal_muscle_development1.42857455
57MP0002234_abnormal_pharynx_morphology1.41426949
58MP0002909_abnormal_adrenal_gland1.41243145
59MP0001440_abnormal_grooming_behavior1.40137781
60MP0002067_abnormal_sensory_capabilities1.37271847
61MP0002272_abnormal_nervous_system1.37189542
62MP0006292_abnormal_olfactory_placode1.36546858
63MP0005508_abnormal_skeleton_morphology1.35597299
64MP0006072_abnormal_retinal_apoptosis1.34366227
65MP0001986_abnormal_taste_sensitivity1.33549093
66MP0002152_abnormal_brain_morphology1.33190859
67MP0002736_abnormal_nociception_after1.31867895
68MP0002638_abnormal_pupillary_reflex1.31353853
69MP0003861_abnormal_nervous_system1.28382014
70MP0001188_hyperpigmentation1.28183554
71MP0003091_abnormal_cell_migration1.20102608
72MP0002653_abnormal_ependyma_morphology1.19899140
73MP0003119_abnormal_digestive_system1.18448413
74MP0003890_abnormal_embryonic-extraembry1.16363632
75MP0002295_abnormal_pulmonary_circulatio1.15925052
76MP0000762_abnormal_tongue_morphology1.15601304
77MP0003123_paternal_imprinting1.15075674
78MP0002751_abnormal_autonomic_nervous1.13442373
79MP0001984_abnormal_olfaction1.12944447
80MP0001502_abnormal_circadian_rhythm1.12487948
81MP0004142_abnormal_muscle_tone1.12471063
82MP0002066_abnormal_motor_capabilities/c1.12328202
83MP0000751_myopathy1.11988520
84MP0001177_atelectasis1.11504978
85MP0000462_abnormal_digestive_system1.11355256
86MP0003646_muscle_fatigue1.10984488
87MP0003705_abnormal_hypodermis_morpholog1.10978388
88MP0000537_abnormal_urethra_morphology1.10248639
89MP0010030_abnormal_orbit_morphology1.09368053
90MP0008789_abnormal_olfactory_epithelium1.09258417
91MP0003935_abnormal_craniofacial_develop1.06743750
92MP0002752_abnormal_somatic_nervous1.06051148
93MP0000767_abnormal_smooth_muscle1.06040119
94MP0004885_abnormal_endolymph1.05071990
95MP0002896_abnormal_bone_mineralization1.03987771
96MP0004084_abnormal_cardiac_muscle1.03212406
97MP0002177_abnormal_outer_ear1.02631943
98MP0003385_abnormal_body_wall1.02070151
99MP0005394_taste/olfaction_phenotype1.01191990
100MP0005499_abnormal_olfactory_system1.01191990
101MP0001299_abnormal_eye_distance/1.01113068
102MP0004858_abnormal_nervous_system1.00239327
103MP0000049_abnormal_middle_ear1.00142135
104MP0003950_abnormal_plasma_membrane0.99524176
105MP0002249_abnormal_larynx_morphology0.98962104
106MP0009278_abnormal_bone_marrow0.97180244
107MP0000534_abnormal_ureter_morphology0.96809659
108MP0008877_abnormal_DNA_methylation0.93585254
109MP0005377_hearing/vestibular/ear_phenot0.90288603
110MP0003878_abnormal_ear_physiology0.90288603
111MP0008770_decreased_survivor_rate0.89471408
112MP0000003_abnormal_adipose_tissue0.88851080
113MP0003942_abnormal_urinary_system0.87457598
114MP0003718_maternal_effect0.86946343
115MP0005171_absent_coat_pigmentation0.86500198
116MP0003938_abnormal_ear_development0.86299515
117MP0008961_abnormal_basal_metabolism0.84790974
118MP0005395_other_phenotype0.84326159
119MP0001243_abnormal_dermal_layer0.83708356
120MP0004134_abnormal_chest_morphology0.82991377
121MP0002108_abnormal_muscle_morphology0.82796258
122MP0000026_abnormal_inner_ear0.82540563
123MP0005187_abnormal_penis_morphology0.82258612
124MP0002233_abnormal_nose_morphology0.81079983
125MP0002938_white_spotting0.80851558
126MP0002116_abnormal_craniofacial_bone0.80502003
127MP0005248_abnormal_Harderian_gland0.80326771
128MP0000678_abnormal_parathyroid_gland0.79903322
129MP0008569_lethality_at_weaning0.79879139
130MP0002060_abnormal_skin_morphology0.79779960
131MP0004085_abnormal_heartbeat0.79233440
132MP0002069_abnormal_eating/drinking_beha0.78845981
133MP0001963_abnormal_hearing_physiology0.78118187
134MP0005197_abnormal_uvea_morphology0.77630218
135MP0000750_abnormal_muscle_regeneration0.76520200
136MP0002081_perinatal_lethality0.75791378
137MP0003137_abnormal_impulse_conducting0.73572695
138MP0000566_synostosis0.72184422
139MP0002109_abnormal_limb_morphology0.71808555
140MP0004742_abnormal_vestibular_system0.71361532
141MP0004043_abnormal_pH_regulation0.70731320
142MP0003755_abnormal_palate_morphology0.70710222
143MP0002282_abnormal_trachea_morphology0.69851320
144MP0003329_amyloid_beta_deposits0.69620694
145MP0003879_abnormal_hair_cell0.69127905

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)6.42021204
2Protrusio acetabuli (HP:0003179)5.31011924
3Limb dystonia (HP:0002451)4.19789287
4Myokymia (HP:0002411)4.12546174
5Neonatal short-limb short stature (HP:0008921)3.94187618
6Ankle contracture (HP:0006466)3.93763297
7Aortic dissection (HP:0002647)3.78427389
8Cortical dysplasia (HP:0002539)3.76473703
9Soft skin (HP:0000977)3.66587157
10Acute lymphatic leukemia (HP:0006721)3.66066607
11Polyphagia (HP:0002591)3.62432422
12Abnormality of dentin (HP:0010299)3.55191212
13Agitation (HP:0000713)3.53140272
14Shallow orbits (HP:0000586)3.49969834
15Mutism (HP:0002300)3.46398091
16Excessive salivation (HP:0003781)3.42373817
17Drooling (HP:0002307)3.42373817
18Focal motor seizures (HP:0011153)3.40982783
19Atrophic scars (HP:0001075)3.39826947
20Ankle clonus (HP:0011448)3.33952828
21Genu recurvatum (HP:0002816)3.23919077
22Bladder diverticulum (HP:0000015)3.19820044
23Follicular hyperkeratosis (HP:0007502)3.10233369
24Peritonitis (HP:0002586)3.03662251
25Progressive cerebellar ataxia (HP:0002073)3.00015658
26Anterior segment dysgenesis (HP:0007700)2.98017776
27Fetal akinesia sequence (HP:0001989)2.97992186
28Morphological abnormality of the middle ear (HP:0008609)2.96506034
29Spinal rigidity (HP:0003306)2.94864200
30Mild short stature (HP:0003502)2.89765558
31Wormian bones (HP:0002645)2.86473001
32Focal seizures (HP:0007359)2.85949929
33Amyotrophic lateral sclerosis (HP:0007354)2.83976016
34Gait imbalance (HP:0002141)2.83679349
35Papillary thyroid carcinoma (HP:0002895)2.83530944
36Hand muscle atrophy (HP:0009130)2.76621551
37Failure to thrive in infancy (HP:0001531)2.74469114
38Broad-based gait (HP:0002136)2.74091581
39Spastic diplegia (HP:0001264)2.73950334
40Bowel diverticulosis (HP:0005222)2.73529598
41Lissencephaly (HP:0001339)2.72164253
42Genetic anticipation (HP:0003743)2.68672078
43Abnormal hair whorl (HP:0010721)2.66675445
44Epileptic encephalopathy (HP:0200134)2.60968499
45Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.60549144
46Fragile skin (HP:0001030)2.58570682
47Abnormality of the labia minora (HP:0012880)2.57952728
48Aortic aneurysm (HP:0004942)2.54478908
49Broad ribs (HP:0000885)2.53890484
50Visual hallucinations (HP:0002367)2.53825966
51Amblyopia (HP:0000646)2.51347920
52Hypoplasia of the brainstem (HP:0002365)2.50204889
53Aplasia/Hypoplasia of the brainstem (HP:0007362)2.50204889
54Spondylolisthesis (HP:0003302)2.48859489
55Hypoventilation (HP:0002791)2.46655837
56Abnormality of the anterior chamber (HP:0000593)2.46529704
57Abnormal eating behavior (HP:0100738)2.45780728
58Hyperextensible skin (HP:0000974)2.41976090
59Slender build (HP:0001533)2.39462042
60Long toe (HP:0010511)2.39396548
61Hypoplasia of the iris (HP:0007676)2.39255083
62Pachygyria (HP:0001302)2.39217025
63Abnormality of the corticospinal tract (HP:0002492)2.39106503
64Febrile seizures (HP:0002373)2.37315749
65Hepatoblastoma (HP:0002884)2.36082363
66Vascular tortuosity (HP:0004948)2.34983897
67Sleep apnea (HP:0010535)2.33459577
68Upper limb amyotrophy (HP:0009129)2.29954674
69Distal upper limb amyotrophy (HP:0007149)2.29954674
70Torticollis (HP:0000473)2.29446151
71Aplasia/Hypoplasia of the lens (HP:0008063)2.27238637
72EEG with generalized epileptiform discharges (HP:0011198)2.27013465
73Type 1 muscle fiber predominance (HP:0003803)2.25905299
74Hyperthyroidism (HP:0000836)2.23961729
75Hypsarrhythmia (HP:0002521)2.23684834
76Keratoconus (HP:0000563)2.21906749
77Increased corneal curvature (HP:0100692)2.21906749
78Epileptiform EEG discharges (HP:0011182)2.21730770
79Spastic gait (HP:0002064)2.20924851
80Akinesia (HP:0002304)2.19251906
81Wide anterior fontanel (HP:0000260)2.18067067
82Specific learning disability (HP:0001328)2.17721872
83Esotropia (HP:0000565)2.16946055
84Infantile muscular hypotonia (HP:0008947)2.16120116
85Protruding tongue (HP:0010808)2.15121137
86Abnormality of salivation (HP:0100755)2.12236347
87Papilledema (HP:0001085)2.11971499
88Aortic regurgitation (HP:0001659)2.10555090
89Narrow nasal bridge (HP:0000446)2.06585895
90Supranuclear gaze palsy (HP:0000605)2.06246155
91Urinary bladder sphincter dysfunction (HP:0002839)2.05859160
92Decreased muscle mass (HP:0003199)2.05751692
93Urinary urgency (HP:0000012)2.05587487
94Generalized tonic-clonic seizures (HP:0002069)2.05214558
95Morphological abnormality of the pyramidal tract (HP:0002062)2.04894925
96Poor suck (HP:0002033)2.04311826
97Obstructive sleep apnea (HP:0002870)2.04223546
98Narrow forehead (HP:0000341)2.03023071
99Nephrogenic diabetes insipidus (HP:0009806)2.02851949
100Abnormality of the intervertebral disk (HP:0005108)2.02577236
101Sacral dimple (HP:0000960)2.00546139
102Hyperventilation (HP:0002883)1.99519583
103Absent speech (HP:0001344)1.98994501
104Retinal dysplasia (HP:0007973)1.98424720
105Thickened helices (HP:0000391)1.97516063
106Hypothermia (HP:0002045)1.97131527
107Hydroureter (HP:0000072)1.96516113
108Upper limb muscle weakness (HP:0003484)1.96192958
109Arterial tortuosity (HP:0005116)1.94630633
110Abnormality of calcium-phosphate metabolism (HP:0100530)1.94241383
111Mitral valve prolapse (HP:0001634)1.93673869
112Facial hemangioma (HP:0000329)1.92835422
113Hallux valgus (HP:0001822)1.90293186
114Focal dystonia (HP:0004373)1.90292061
115Progressive inability to walk (HP:0002505)1.89876000
116Blue sclerae (HP:0000592)1.89786841
117Delayed gross motor development (HP:0002194)1.89520185
118Inappropriate behavior (HP:0000719)1.88831345
119Impaired vibration sensation in the lower limbs (HP:0002166)1.88522134
120Type 2 muscle fiber atrophy (HP:0003554)1.88230133
121Broad metatarsal (HP:0001783)1.87553033
122Poor eye contact (HP:0000817)1.86965841
123Abnormality of the lower motor neuron (HP:0002366)1.86950996
124Limb-girdle muscle weakness (HP:0003325)1.86563857
125Atelectasis (HP:0100750)1.85717249
126Sporadic (HP:0003745)1.85679593
127Absence seizures (HP:0002121)1.85354839
128Craniofacial dystonia (HP:0012179)1.84680230
129Shoulder girdle muscle weakness (HP:0003547)1.83895774
130Medial flaring of the eyebrow (HP:0010747)1.83703731
131Nonimmune hydrops fetalis (HP:0001790)1.83189952
132Dilatation of the ascending aorta (HP:0005111)1.82990884
133Shawl scrotum (HP:0000049)1.82249714
134Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.81973509
135Congenital primary aphakia (HP:0007707)1.81197179
136Pheochromocytoma (HP:0002666)1.81121894
137Aortic valve stenosis (HP:0001650)1.80225653
138Venous insufficiency (HP:0005293)1.80175130
139Open mouth (HP:0000194)1.79446977
140Exotropia (HP:0000577)1.78867848
141Deviation of the hallux (HP:0010051)1.78813822
142Buphthalmos (HP:0000557)1.78429834
143Molar tooth sign on MRI (HP:0002419)1.77949490
144Abnormality of midbrain morphology (HP:0002418)1.77949490
145Elbow flexion contracture (HP:0002987)1.77146322
146Atonic seizures (HP:0010819)1.75251269
147Termporal pattern (HP:0011008)1.75213818
148Insidious onset (HP:0003587)1.75213818
149Neoplasm of the heart (HP:0100544)1.74204217
150Thyroid carcinoma (HP:0002890)1.74056132
151Joint laxity (HP:0001388)1.73469138
152Striae distensae (HP:0001065)1.71833092
153Anxiety (HP:0000739)1.71702179
154Lower limb muscle weakness (HP:0007340)1.71541930
155Spastic tetraplegia (HP:0002510)1.70604195
156Complete atrioventricular canal defect (HP:0001674)1.70399457
157Absent frontal sinuses (HP:0002688)1.70340930
158Osteoarthritis (HP:0002758)1.70166288
159Hypercortisolism (HP:0001578)1.70032612
160Generalized hypotonia (HP:0001290)1.69311458
161Apathy (HP:0000741)1.67727949
162Cutaneous finger syndactyly (HP:0010554)1.67661380
163Wrist flexion contracture (HP:0001239)1.67616906
164Short 4th metacarpal (HP:0010044)1.67597869
165Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.67597869
166Clonus (HP:0002169)1.67063378
167Hemiparesis (HP:0001269)1.66775340
168Ectopia lentis (HP:0001083)1.66462073
169Diminished motivation (HP:0000745)1.65914165
170Hypoplasia of the corpus callosum (HP:0002079)1.64731102
171Abnormal delivery (HP:0001787)1.64730188
172High anterior hairline (HP:0009890)1.64643918
173Cerebral aneurysm (HP:0004944)1.64619787
174Paraplegia (HP:0010550)1.63625525
175Midline defect of the nose (HP:0004122)1.62507397
176Short philtrum (HP:0000322)1.62313149
177Genital tract atresia (HP:0001827)1.62235656

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK16.84144915
2MAPK133.64798378
3MAP3K93.21441138
4DYRK23.16113002
5NTRK33.14588524
6PRKD32.92248574
7TRIM282.88842156
8NTRK22.81838669
9MAP2K72.56277868
10MAP3K42.54764479
11MAP4K22.29713513
12CASK2.27649294
13WNK32.27052300
14MINK12.25091048
15TESK12.11176139
16LATS22.01363885
17KSR11.91428439
18ERBB31.81561079
19UHMK11.72949657
20CSNK1G21.67897316
21TIE11.65873142
22PAK61.64296751
23PIK3CG1.61355636
24DDR21.61025427
25CSNK1G31.59730586
26PHKG11.57799838
27PHKG21.57799838
28EPHA31.54802748
29PAK21.51878357
30STK38L1.48253096
31SIK21.45111818
32MYLK1.44583528
33LIMK11.41761350
34MOS1.40471013
35FLT31.38018777
36MAP3K61.32139715
37KIT1.31791868
38PDGFRA1.29917600
39BCR1.27173663
40MAP2K41.22114551
41PINK11.20217564
42CSNK1G11.19981753
43PTK21.18289468
44NEK91.16138681
45SIK31.13973489
46EPHA41.10293860
47RPS6KA21.09880014
48MAP3K121.06377110
49CDK51.05651021
50TAOK11.04937148
51MARK21.04185427
52CSNK1A1L1.03026653
53MAP3K31.01590031
54BRAF1.01191928
55BMPR1B1.00824035
56TESK21.00118605
57EPHB20.96082926
58PRKCZ0.95175720
59PLK20.94694221
60PAK30.92208456
61MET0.92041148
62DYRK1A0.91688948
63SGK4940.90700994
64SGK2230.90700994
65ERBB40.87617319
66GRK70.87321645
67MUSK0.86335441
68CDK180.86304132
69CAMK2A0.83318096
70KSR20.83107027
71AURKA0.79871243
72OXSR10.79786861
73CDK150.78759682
74PIM20.76655553
75CDK140.76110409
76LMTK20.75728445
77CDK90.73095781
78CAMKK20.72280234
79PRKCG0.70346052
80SGK20.69701470
81CLK10.67766225
82PKN10.67166151
83CDK11A0.66824463
84TTN0.65528486
85DMPK0.65351902
86TNIK0.64487956
87SCYL20.61697499
88PLK30.59584322
89DAPK20.59545174
90PRKD20.59542064
91WNK40.57312376
92MAP3K130.56474219
93ADRBK20.56094340
94MAPK90.55228530
95PRKCI0.54801056
96ARAF0.53485657
97STK110.52932941
98ROCK10.52812021
99DYRK1B0.52609423
100GRK50.52042592
101PRKCE0.51484288
102PRKCH0.51168487
103TYRO30.50602329
104CDC42BPA0.50438986
105ABL20.49958055
106ADRBK10.49661880
107PRKACB0.48759686
108PRKAA10.47943909
109PRKG10.45991847
110CDK190.42362954
111MTOR0.38790169
112MAP3K20.38187404
113DAPK10.37549812
114GSK3A0.37388489
115PTK2B0.37164887
116BMPR20.36628111
117MAPK40.36477285
118RAF10.36272697
119SGK10.36194360
120MAPK10.35683512
121CDK80.34988301
122CHEK20.34492718
123ICK0.34433224
124RET0.34077739
125PKN20.33212648
126VRK10.32523076
127RPS6KB10.31992712
128LATS10.31987954
129CDK30.31620170
130EEF2K0.30318489
131TAOK30.30141226
132MAPK80.29701624
133EIF2AK20.28960039
134RPS6KA30.28677275
135CSNK1E0.27351261
136GSK3B0.26133992
137CAMK2B0.25700329
138NTRK10.25478480
139SGK30.24966715
140CAMK40.24966161
141CSNK1D0.24773283
142STK380.24526709
143PRKACA0.23441814

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.43123390
2Synaptic vesicle cycle_Homo sapiens_hsa047213.07237104
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.67987746
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.38003970
5Cocaine addiction_Homo sapiens_hsa050302.37358860
6Serotonergic synapse_Homo sapiens_hsa047262.35364120
7GABAergic synapse_Homo sapiens_hsa047272.34435582
8Dopaminergic synapse_Homo sapiens_hsa047282.32679539
9Axon guidance_Homo sapiens_hsa043602.31172512
10ECM-receptor interaction_Homo sapiens_hsa045122.25892206
11Glutamatergic synapse_Homo sapiens_hsa047242.15812383
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.12374088
13Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.11449851
14Circadian entrainment_Homo sapiens_hsa047132.10558431
15Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.06766660
16Insulin secretion_Homo sapiens_hsa049111.95344043
17Morphine addiction_Homo sapiens_hsa050321.92396560
18Amphetamine addiction_Homo sapiens_hsa050311.87834773
19Cholinergic synapse_Homo sapiens_hsa047251.86317588
20Focal adhesion_Homo sapiens_hsa045101.67108948
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.65321499
22Olfactory transduction_Homo sapiens_hsa047401.64774235
23Taste transduction_Homo sapiens_hsa047421.61833350
24Gap junction_Homo sapiens_hsa045401.51188243
25Long-term potentiation_Homo sapiens_hsa047201.50120035
26Basal transcription factors_Homo sapiens_hsa030221.45771726
27Long-term depression_Homo sapiens_hsa047301.43993647
28Collecting duct acid secretion_Homo sapiens_hsa049661.43580196
29Protein digestion and absorption_Homo sapiens_hsa049741.41382917
30Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.34665840
31Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.33233182
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.32095022
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.30200321
34Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.30071522
35Colorectal cancer_Homo sapiens_hsa052101.29901591
36GnRH signaling pathway_Homo sapiens_hsa049121.29684300
37ErbB signaling pathway_Homo sapiens_hsa040121.27382444
38Aldosterone synthesis and secretion_Homo sapiens_hsa049251.27340434
39Melanoma_Homo sapiens_hsa052181.26950039
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.24296576
41Type II diabetes mellitus_Homo sapiens_hsa049301.24187189
42Endometrial cancer_Homo sapiens_hsa052131.22797491
43Amoebiasis_Homo sapiens_hsa051461.20903751
44Vibrio cholerae infection_Homo sapiens_hsa051101.20553566
45Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.18214618
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16948752
47Ovarian steroidogenesis_Homo sapiens_hsa049131.16593905
48Oocyte meiosis_Homo sapiens_hsa041141.14288435
49Butanoate metabolism_Homo sapiens_hsa006501.07897439
50Regulation of actin cytoskeleton_Homo sapiens_hsa048101.06614502
51Oxytocin signaling pathway_Homo sapiens_hsa049211.04410648
52PI3K-Akt signaling pathway_Homo sapiens_hsa041511.03928018
53Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.00332530
54Estrogen signaling pathway_Homo sapiens_hsa049150.99256755
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.96766408
56Renin secretion_Homo sapiens_hsa049240.95997250
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.93881984
58Renal cell carcinoma_Homo sapiens_hsa052110.93788248
59Alcoholism_Homo sapiens_hsa050340.93592207
60Salivary secretion_Homo sapiens_hsa049700.92313333
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.92259163
62Shigellosis_Homo sapiens_hsa051310.92178538
63Gastric acid secretion_Homo sapiens_hsa049710.91125866
64Melanogenesis_Homo sapiens_hsa049160.90916493
65Cardiac muscle contraction_Homo sapiens_hsa042600.90034095
66Small cell lung cancer_Homo sapiens_hsa052220.89865557
67Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.89269177
68Ras signaling pathway_Homo sapiens_hsa040140.88604002
69cAMP signaling pathway_Homo sapiens_hsa040240.87982712
70Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86561240
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.84822631
72Choline metabolism in cancer_Homo sapiens_hsa052310.84528693
73Circadian rhythm_Homo sapiens_hsa047100.83383954
74MAPK signaling pathway_Homo sapiens_hsa040100.80580876
75Glycosaminoglycan degradation_Homo sapiens_hsa005310.78807658
76Hedgehog signaling pathway_Homo sapiens_hsa043400.78478641
77Wnt signaling pathway_Homo sapiens_hsa043100.78281345
78Glioma_Homo sapiens_hsa052140.78191189
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77912101
80Hippo signaling pathway_Homo sapiens_hsa043900.76446875
81Phototransduction_Homo sapiens_hsa047440.76320022
82Dorso-ventral axis formation_Homo sapiens_hsa043200.73759464
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71910823
84Type I diabetes mellitus_Homo sapiens_hsa049400.70995331
85Prolactin signaling pathway_Homo sapiens_hsa049170.69536524
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68934724
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65769288
88Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64246653
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64103462
90Parkinsons disease_Homo sapiens_hsa050120.62171020
91mTOR signaling pathway_Homo sapiens_hsa041500.62128565
92N-Glycan biosynthesis_Homo sapiens_hsa005100.61802235
93Pathways in cancer_Homo sapiens_hsa052000.61548296
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61443606
95Calcium signaling pathway_Homo sapiens_hsa040200.60813130
96Pancreatic cancer_Homo sapiens_hsa052120.60750003
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59141433
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58535592
99Dilated cardiomyopathy_Homo sapiens_hsa054140.58404201
100Basal cell carcinoma_Homo sapiens_hsa052170.57859296
101Oxidative phosphorylation_Homo sapiens_hsa001900.56708964
102Proteoglycans in cancer_Homo sapiens_hsa052050.56318102
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55610291
104Protein export_Homo sapiens_hsa030600.54947423
105Alzheimers disease_Homo sapiens_hsa050100.54931010
106Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54823045
107Vascular smooth muscle contraction_Homo sapiens_hsa042700.54402411
108Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.53941359
109Huntingtons disease_Homo sapiens_hsa050160.52975005
110Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.52177731
111Rap1 signaling pathway_Homo sapiens_hsa040150.51795574
112Phospholipase D signaling pathway_Homo sapiens_hsa040720.51545792
113cGMP-PKG signaling pathway_Homo sapiens_hsa040220.50824253
114Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49741874
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.49696557
116TGF-beta signaling pathway_Homo sapiens_hsa043500.48924680
117Insulin signaling pathway_Homo sapiens_hsa049100.48704341
118Non-small cell lung cancer_Homo sapiens_hsa052230.48311081
119mRNA surveillance pathway_Homo sapiens_hsa030150.48033557
120Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47947714
121Salmonella infection_Homo sapiens_hsa051320.47766337
122Adherens junction_Homo sapiens_hsa045200.46939454
123Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46237988
124Phagosome_Homo sapiens_hsa041450.45930361
125Prion diseases_Homo sapiens_hsa050200.45654433
126SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42103478
127MicroRNAs in cancer_Homo sapiens_hsa052060.42053408
128VEGF signaling pathway_Homo sapiens_hsa043700.41787820
129AMPK signaling pathway_Homo sapiens_hsa041520.39346674

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