STK26

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)5.51126805
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.37629371
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.37629371
4ribosomal small subunit assembly (GO:0000028)5.28211237
5positive regulation of gamma-delta T cell activation (GO:0046645)5.18298495
6pore complex assembly (GO:0046931)4.62819570
7antigen processing and presentation of endogenous antigen (GO:0019883)4.53764439
8regulation of gamma-delta T cell differentiation (GO:0045586)4.25322549
9negative regulation of phagocytosis (GO:0050765)4.15223507
10positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.08102154
11definitive hemopoiesis (GO:0060216)4.03013790
12CENP-A containing nucleosome assembly (GO:0034080)3.94671440
13pre-miRNA processing (GO:0031054)3.94544286
14chromatin remodeling at centromere (GO:0031055)3.93211532
15DNA unwinding involved in DNA replication (GO:0006268)3.85156251
16regulation of gamma-delta T cell activation (GO:0046643)3.81915619
17establishment of integrated proviral latency (GO:0075713)3.77716218
18purine nucleobase biosynthetic process (GO:0009113)3.74107357
19viral transcription (GO:0019083)3.67061777
20positive regulation of B cell differentiation (GO:0045579)3.66907690
21negative T cell selection (GO:0043383)3.65186212
22mitotic G2/M transition checkpoint (GO:0044818)3.63455745
23antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.62653490
24leukocyte aggregation (GO:0070486)3.60889795
25regulation of histone H3-K9 methylation (GO:0051570)3.54768422
26ribosome assembly (GO:0042255)3.54293092
27translational termination (GO:0006415)3.54141217
28protein localization to chromosome, centromeric region (GO:0071459)3.52536150
29negative thymic T cell selection (GO:0045060)3.51096812
30telomere maintenance via semi-conservative replication (GO:0032201)3.49989644
31DNA replication checkpoint (GO:0000076)3.45930854
32double-strand break repair via nonhomologous end joining (GO:0006303)3.45770847
33non-recombinational repair (GO:0000726)3.45770847
34SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.43407239
35T cell homeostasis (GO:0043029)3.42706610
36DNA replication-independent nucleosome assembly (GO:0006336)3.42471185
37DNA replication-independent nucleosome organization (GO:0034724)3.42471185
38mitotic nuclear envelope disassembly (GO:0007077)3.41689249
39DNA strand elongation involved in DNA replication (GO:0006271)3.39926378
40mitotic G2 DNA damage checkpoint (GO:0007095)3.38226377
41antigen processing and presentation via MHC class Ib (GO:0002475)3.37440761
42mitotic chromosome condensation (GO:0007076)3.35729350
43megakaryocyte development (GO:0035855)3.35726700
44cotranslational protein targeting to membrane (GO:0006613)3.32868615
45protein targeting to ER (GO:0045047)3.32413571
46formation of translation preinitiation complex (GO:0001731)3.32090668
47DNA strand elongation (GO:0022616)3.31933362
48DNA ligation (GO:0006266)3.31895807
49mast cell activation (GO:0045576)3.29843498
50heterochromatin organization (GO:0070828)3.28743770
51regulation of B cell receptor signaling pathway (GO:0050855)3.27158197
52regulation of B cell differentiation (GO:0045577)3.22543119
53negative regulation of chromosome segregation (GO:0051985)3.21815458
54response to interleukin-15 (GO:0070672)3.21630744
55DNA topological change (GO:0006265)3.20940853
56histone exchange (GO:0043486)3.20439180
57negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.19867971
58negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.19867971
59negative regulation of mitotic sister chromatid segregation (GO:0033048)3.19867971
60negative regulation of mitotic sister chromatid separation (GO:2000816)3.19867971
61negative regulation of sister chromatid segregation (GO:0033046)3.19867971
62mitotic metaphase plate congression (GO:0007080)3.19726952
63sister chromatid segregation (GO:0000819)3.19042663
64negative regulation of cell killing (GO:0031342)3.18330537
65negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.18330537
66translational elongation (GO:0006414)3.18199579
67regulation of helicase activity (GO:0051095)3.17703721
68interferon-gamma production (GO:0032609)3.16640839
69establishment of protein localization to endoplasmic reticulum (GO:0072599)3.16542249
70membrane disassembly (GO:0030397)3.15487910
71nuclear envelope disassembly (GO:0051081)3.15487910
72regulation of centriole replication (GO:0046599)3.13495887
73negative regulation of erythrocyte differentiation (GO:0045647)3.13292940
74protein localization to endoplasmic reticulum (GO:0070972)3.11998800
75telomere maintenance via recombination (GO:0000722)3.10921628
76Arp2/3 complex-mediated actin nucleation (GO:0034314)3.10396419
77DNA deamination (GO:0045006)3.07415933
78regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.05197655
79regulation of mitotic metaphase/anaphase transition (GO:0030071)3.05197655
80mitotic sister chromatid segregation (GO:0000070)3.04694850
81mitotic recombination (GO:0006312)3.02196208
82positive thymic T cell selection (GO:0045059)3.00615501
83mitotic spindle checkpoint (GO:0071174)2.99025629
84ribosomal small subunit biogenesis (GO:0042274)2.97967200
85negative regulation of DNA repair (GO:0045738)2.97336314
86nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.97048080
87mitotic spindle assembly checkpoint (GO:0007094)2.96831041
88B cell receptor signaling pathway (GO:0050853)2.96592881
89ATP-dependent chromatin remodeling (GO:0043044)2.94736861
90protein complex localization (GO:0031503)2.94146482
91spindle checkpoint (GO:0031577)2.93668628
92regulation of sister chromatid segregation (GO:0033045)2.92294059
93regulation of mitotic sister chromatid separation (GO:0010965)2.92294059
94regulation of mitotic sister chromatid segregation (GO:0033047)2.92294059
95spindle assembly checkpoint (GO:0071173)2.92112326
96negative regulation of RNA splicing (GO:0033119)2.91783623
97somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.91535369
98somatic cell DNA recombination (GO:0016444)2.91535369
99regulation of chromosome segregation (GO:0051983)2.90135439
100mast cell degranulation (GO:0043303)2.88251811
101mast cell activation involved in immune response (GO:0002279)2.88251811
102establishment of viral latency (GO:0019043)2.87381668
103necroptotic process (GO:0070266)2.85764215
104maturation of SSU-rRNA (GO:0030490)2.85157426
105chromatin assembly or disassembly (GO:0006333)2.84796791
106folic acid-containing compound biosynthetic process (GO:0009396)2.83447794
107mitotic sister chromatid cohesion (GO:0007064)2.81425198
108regulation of RNA export from nucleus (GO:0046831)2.81285518
109IMP metabolic process (GO:0046040)2.81153772
110DNA replication-dependent nucleosome organization (GO:0034723)2.80258129
111DNA replication-dependent nucleosome assembly (GO:0006335)2.80258129
112thymic T cell selection (GO:0045061)2.79924196
113somatic diversification of immune receptors via somatic mutation (GO:0002566)2.79693121
114somatic hypermutation of immunoglobulin genes (GO:0016446)2.79693121
115lymphocyte homeostasis (GO:0002260)2.79396654
116DNA replication initiation (GO:0006270)2.79351194
117kinetochore organization (GO:0051383)2.79157059
118positive T cell selection (GO:0043368)2.79022531
119T cell selection (GO:0045058)2.78557919
120DNA conformation change (GO:0071103)2.76882481
121metaphase plate congression (GO:0051310)2.75549591
122regulation of T cell receptor signaling pathway (GO:0050856)2.75506465
123regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.75272883
124regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.73819629
125viral life cycle (GO:0019058)2.73798402
126IMP biosynthetic process (GO:0006188)2.73183839
127cellular response to interleukin-15 (GO:0071350)2.72586223
128T cell migration (GO:0072678)2.71233013
129cellular protein complex localization (GO:0034629)2.70126237
130cellular protein complex disassembly (GO:0043624)2.68590784
131regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.68396810
132negative regulation of mRNA metabolic process (GO:1903312)2.68364834
133translational initiation (GO:0006413)2.67563318
134negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.67218419
135negative regulation of mRNA processing (GO:0050686)2.67072675
136positive regulation of chromosome segregation (GO:0051984)2.67034996
137somatic diversification of immune receptors (GO:0002200)2.66477063
138positive regulation of granulocyte differentiation (GO:0030854)2.66196641
139V(D)J recombination (GO:0033151)2.64670268
140negative regulation of DNA-dependent DNA replication (GO:2000104)2.62514846
141telomere maintenance via telomere lengthening (GO:0010833)2.62299006
142response to protozoan (GO:0001562)2.60012384
143positive regulation of isotype switching (GO:0045830)2.58687051
144translesion synthesis (GO:0019985)2.58646698
145alternative mRNA splicing, via spliceosome (GO:0000380)2.58330037
146regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.57897612
147leukocyte homeostasis (GO:0001776)2.56986804
148somatic recombination of immunoglobulin gene segments (GO:0016447)2.56815887
149positive regulation of SMAD protein import into nucleus (GO:0060391)2.56745433
150myeloid dendritic cell activation (GO:0001773)2.56444402
151DNA duplex unwinding (GO:0032508)2.56161424
1523-UTR-mediated mRNA stabilization (GO:0070935)2.55500713
153establishment of chromosome localization (GO:0051303)2.55027023
154nuclear-transcribed mRNA catabolic process (GO:0000956)2.54680785
155protein localization to kinetochore (GO:0034501)2.53738105
156T cell differentiation (GO:0030217)2.53356743
157regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.52976895
158dosage compensation (GO:0007549)2.52863538
159nucleotide-excision repair, DNA gap filling (GO:0006297)2.52386188
160protein complex disassembly (GO:0043241)2.52252531
161DNA geometric change (GO:0032392)2.52134351
162antigen receptor-mediated signaling pathway (GO:0050851)2.51834470
163regulation of erythrocyte differentiation (GO:0045646)2.51566141
164regulation of necroptotic process (GO:0060544)2.51155824
165somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.50605382
166isotype switching (GO:0045190)2.50605382
167somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.50605382
168regulation of sister chromatid cohesion (GO:0007063)2.49457201
169angiogenesis involved in wound healing (GO:0060055)2.47900194
170telomere maintenance (GO:0000723)2.47465657
171telomere organization (GO:0032200)2.45286269
172mRNA catabolic process (GO:0006402)2.44810459
173regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.44580379
174regulation of DNA endoreduplication (GO:0032875)2.44351488
175T cell receptor signaling pathway (GO:0050852)2.41981339
176nuclear pore complex assembly (GO:0051292)2.41843716
177nucleobase biosynthetic process (GO:0046112)2.40132555

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.23729717
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.34825617
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.29130123
4MYC_22102868_ChIP-Seq_BL_Human3.15656699
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.05575990
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.99296285
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.99169777
8SCL_19346495_ChIP-Seq_HPC-7_Human2.98309707
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.90451742
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.76432548
11SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.73555456
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.73492593
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.71325035
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.66816607
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.55043382
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.44833684
17VDR_21846776_ChIP-Seq_THP-1_Human2.41737639
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.41317930
19KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.35957281
20TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.30932838
21MYB_26560356_Chip-Seq_TH2_Human2.30612313
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.21770618
23STAT4_19710469_ChIP-ChIP_TH1__Mouse2.10966159
24SPI1_23547873_ChIP-Seq_NB4_Human2.10847416
25ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.09760802
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.06516586
27FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.02446104
28MYB_26560356_Chip-Seq_TH1_Human1.98715223
29FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.97369756
30STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.96911064
31SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.94126261
32VDR_23849224_ChIP-Seq_CD4+_Human1.91606952
33MAF_26560356_Chip-Seq_TH1_Human1.91043131
34HOXB4_20404135_ChIP-ChIP_EML_Mouse1.87950108
35NOTCH1_21737748_ChIP-Seq_TLL_Human1.85043832
36CIITA_25753668_ChIP-Seq_RAJI_Human1.84117762
37UTX_26944678_Chip-Seq_JUKART_Human1.83545516
38SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.83376478
39ERG_20887958_ChIP-Seq_HPC-7_Mouse1.81710026
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.79040555
41FOXP3_21729870_ChIP-Seq_TREG_Human1.78695697
42EST1_17652178_ChIP-ChIP_JURKAT_Human1.78314108
43KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.77674037
44KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.77674037
45KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.77674037
46RUNX_20019798_ChIP-Seq_JUKART_Human1.76195470
47E2F1_21310950_ChIP-Seq_MCF-7_Human1.75814953
48VDR_24763502_ChIP-Seq_THP-1_Human1.74738072
49GATA1_22025678_ChIP-Seq_K562_Human1.70815033
50SALL1_21062744_ChIP-ChIP_HESCs_Human1.70420180
51MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.68598207
52GABP_17652178_ChIP-ChIP_JURKAT_Human1.67341543
53IRF8_21731497_ChIP-ChIP_J774_Mouse1.66019339
54MYC_19030024_ChIP-ChIP_MESCs_Mouse1.63607178
55IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.62647054
56E2F1_18555785_ChIP-Seq_MESCs_Mouse1.62116250
57TCF7_22412390_ChIP-Seq_EML_Mouse1.61367924
58BP1_19119308_ChIP-ChIP_Hs578T_Human1.60947355
59GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.59268823
60MYC_19079543_ChIP-ChIP_MESCs_Mouse1.57936662
61BRD4_27068464_Chip-Seq_AML-cells_Mouse1.57527686
62PADI4_21655091_ChIP-ChIP_MCF-7_Human1.56228542
63NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.55454650
64FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.55196175
65POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.53905002
66MYC_18358816_ChIP-ChIP_MESCs_Mouse1.53704191
67ELK1_19687146_ChIP-ChIP_HELA_Human1.53568517
68HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.52651979
69SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.47858155
70MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.47846192
71XRN2_22483619_ChIP-Seq_HELA_Human1.47135910
72PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40946531
73NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.40730569
74ETS1_20019798_ChIP-Seq_JURKAT_Human1.40142990
75PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.39697604
76GATA2_22383799_ChIP-Seq_G1ME_Mouse1.38614334
77KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.35449197
78GATA1_22383799_ChIP-Seq_G1ME_Mouse1.31052462
79NELFA_20434984_ChIP-Seq_ESCs_Mouse1.28852242
80GATA3_27048872_Chip-Seq_THYMUS_Human1.26762236
81IRF8_27001747_Chip-Seq_BMDM_Mouse1.26747869
82CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.26119970
83LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.25410272
84THAP11_20581084_ChIP-Seq_MESCs_Mouse1.24923470
85E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.23388318
86JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.22099918
87NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.21452661
88SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.19904251
89MAF_26560356_Chip-Seq_TH2_Human1.18561853
90NANOG_18555785_ChIP-Seq_MESCs_Mouse1.18438450
91CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.18084591
92TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.17131450
93E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16991936
94GABP_19822575_ChIP-Seq_HepG2_Human1.14086889
95LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.13372924
96FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.13201568
97MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.11692738
98NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.10235668
99TTF2_22483619_ChIP-Seq_HELA_Human1.09938875
100KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08908822
101ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.08109049
102RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.07600191
103SPI1_23127762_ChIP-Seq_K562_Human1.07571888
104KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07508486
105ZFX_18555785_ChIP-Seq_MESCs_Mouse1.07432384
106NANOG_16153702_ChIP-ChIP_HESCs_Human1.06346312
107KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.05839212
108CREB1_15753290_ChIP-ChIP_HEK293T_Human1.05595553
109DCP1A_22483619_ChIP-Seq_HELA_Human1.05576667
110MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.03798558
111KDM5A_27292631_Chip-Seq_BREAST_Human1.02347400
112TP63_19390658_ChIP-ChIP_HaCaT_Human1.01133442
113YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99442565
114STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.99107504
115PU_27001747_Chip-Seq_BMDM_Mouse0.98727273
116MYCN_18555785_ChIP-Seq_MESCs_Mouse0.98664203
117CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.96908571
118TFEB_21752829_ChIP-Seq_HELA_Human0.96802009
119CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.96323667
120AR_21909140_ChIP-Seq_LNCAP_Human0.96222117
121ETS1_22383799_ChIP-Seq_G1ME_Mouse0.94596945
122CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94557677
123MYC_18940864_ChIP-ChIP_HL60_Human0.92470075
124SOX2_16153702_ChIP-ChIP_HESCs_Human0.92341994
125NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.91562168
126CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.90131391
127SOX2_18555785_ChIP-Seq_MESCs_Mouse0.87538372
128E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.87292599
129STAT3_1855785_ChIP-Seq_MESCs_Mouse0.86769661
130ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86600354
131NANOG_21062744_ChIP-ChIP_HESCs_Human0.86081915
132SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.85842164
133RBPJ_22232070_ChIP-Seq_NCS_Mouse0.85744437

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system4.03931725
2MP0003763_abnormal_thymus_physiology3.73358048
3MP0001835_abnormal_antigen_presentation3.11560214
4MP0005671_abnormal_response_to3.01843236
5MP0004808_abnormal_hematopoietic_stem2.88962708
6MP0000685_abnormal_immune_system2.77865149
7MP0002398_abnormal_bone_marrow2.63427725
8MP0010094_abnormal_chromosome_stability2.57621223
9MP0002166_altered_tumor_susceptibility2.56786359
10MP0001800_abnormal_humoral_immune2.52021747
11MP0008057_abnormal_DNA_replication2.43902494
12MP0003693_abnormal_embryo_hatching2.39904885
13MP0009785_altered_susceptibility_to2.39195635
14MP0002420_abnormal_adaptive_immunity2.34677138
15MP0003436_decreased_susceptibility_to2.32558953
16MP0001819_abnormal_immune_cell2.29694936
17MP0005464_abnormal_platelet_physiology2.26870141
18MP0008932_abnormal_embryonic_tissue2.26165390
19MP0000465_gastrointestinal_hemorrhage2.25705713
20MP0000703_abnormal_thymus_morphology2.21855259
21MP0003890_abnormal_embryonic-extraembry2.19414966
22MP0002452_abnormal_antigen_presenting2.17618008
23MP0003941_abnormal_skin_development2.16761925
24MP0005000_abnormal_immune_tolerance2.16093870
25MP0002723_abnormal_immune_serum2.15128381
26MP0000716_abnormal_immune_system2.15098361
27MP0002722_abnormal_immune_system2.14359678
28MP0005025_abnormal_response_to2.11789140
29MP0000689_abnormal_spleen_morphology2.11058249
30MP0005397_hematopoietic_system_phenotyp2.10957107
31MP0001545_abnormal_hematopoietic_system2.10957107
32MP0009697_abnormal_copulation2.08548911
33MP0001873_stomach_inflammation2.02818928
34MP0005387_immune_system_phenotype2.02284839
35MP0001790_abnormal_immune_system2.02284839
36MP0002006_tumorigenesis2.01354250
37MP0005174_abnormal_tail_pigmentation1.97445344
38MP0002429_abnormal_blood_cell1.92379455
39MP0000490_abnormal_crypts_of1.91661606
40MP0003077_abnormal_cell_cycle1.89967083
41MP0009333_abnormal_splenocyte_physiolog1.89427606
42MP0010155_abnormal_intestine_physiology1.85377946
43MP0002405_respiratory_system_inflammati1.85085694
44MP0004957_abnormal_blastocyst_morpholog1.84974274
45MP0002419_abnormal_innate_immunity1.82837914
46MP0003866_abnormal_defecation1.81525562
47MP0006054_spinal_hemorrhage1.79027149
48MP0003111_abnormal_nucleus_morphology1.77879174
49MP0008007_abnormal_cellular_replicative1.76748307
50MP0003300_gastrointestinal_ulcer1.75120191
51MP0008058_abnormal_DNA_repair1.75068707
52MP0005380_embryogenesis_phenotype1.69382300
53MP0001672_abnormal_embryogenesis/_devel1.69382300
54MP0009672_abnormal_birth_weight1.66821496
55MP0002933_joint_inflammation1.62100080
56MP0003303_peritoneal_inflammation1.61640102
57MP0001853_heart_inflammation1.60749694
58MP0009278_abnormal_bone_marrow1.57772282
59MP0003984_embryonic_growth_retardation1.56556733
60MP0002148_abnormal_hypersensitivity_rea1.55810289
61MP0002088_abnormal_embryonic_growth/wei1.52471166
62MP0002254_reproductive_system_inflammat1.51164226
63MP0001697_abnormal_embryo_size1.50923378
64MP0003724_increased_susceptibility_to1.50564607
65MP0005075_abnormal_melanosome_morpholog1.46625697
66MP0003221_abnormal_cardiomyocyte_apopto1.46246173
67MP0002095_abnormal_skin_pigmentation1.45288972
68MP0002019_abnormal_tumor_incidence1.41085953
69MP0001845_abnormal_inflammatory_respons1.40195678
70MP0001293_anophthalmia1.35564094
71MP0004185_abnormal_adipocyte_glucose1.35008884
72MP0002877_abnormal_melanocyte_morpholog1.31982619
73MP0010352_gastrointestinal_tract_polyps1.27737965
74MP0000858_altered_metastatic_potential1.24511185
75MP0002084_abnormal_developmental_patter1.22080756
76MP0004947_skin_inflammation1.22032511
77MP0002009_preneoplasia1.15612428
78MP0010307_abnormal_tumor_latency1.15130627
79MP0001533_abnormal_skeleton_physiology1.13999060
80MP0002085_abnormal_embryonic_tissue1.13725364
81MP0003183_abnormal_peptide_metabolism1.09988073
82MP0006035_abnormal_mitochondrial_morpho1.00342002
83MP0000313_abnormal_cell_death1.00216838
84MP0003718_maternal_effect0.98801420
85MP0000350_abnormal_cell_proliferation0.96195005
86MP0001851_eye_inflammation0.96037148
87MP0009703_decreased_birth_body0.95614153
88MP0003943_abnormal_hepatobiliary_system0.95544302
89MP0000015_abnormal_ear_pigmentation0.94067894
90MP0001986_abnormal_taste_sensitivity0.92865887
91MP0005310_abnormal_salivary_gland0.89844673
92MP0006082_CNS_inflammation0.87865917
93MP0002796_impaired_skin_barrier0.87363910
94MP0008469_abnormal_protein_level0.85539373
95MP0005384_cellular_phenotype0.83500457
96MP0000358_abnormal_cell_content/0.82826846
97MP0008260_abnormal_autophagy0.78632862
98MP0003806_abnormal_nucleotide_metabolis0.78630209
99MP0003448_altered_tumor_morphology0.78313420
100MP0010234_abnormal_vibrissa_follicle0.77881132
101MP0002697_abnormal_eye_size0.77435489
102MP0003453_abnormal_keratinocyte_physiol0.76738801
103MP0003786_premature_aging0.74565313
104MP0001286_abnormal_eye_development0.74402866
105MP0001915_intracranial_hemorrhage0.73606440
106MP0008004_abnormal_stomach_pH0.72298871
107MP0003795_abnormal_bone_structure0.71455869
108MP0005451_abnormal_body_composition0.69976385
109MP0003172_abnormal_lysosome_physiology0.69948131
110MP0001849_ear_inflammation0.69792157
111MP0002111_abnormal_tail_morphology0.69601344
112MP0004134_abnormal_chest_morphology0.68666774
113MP0003123_paternal_imprinting0.68472711
114MP0001663_abnormal_digestive_system0.66414340
115MP0005409_darkened_coat_color0.65847264
116MP0000477_abnormal_intestine_morphology0.65456211
117MP0005023_abnormal_wound_healing0.65115605
118MP0001730_embryonic_growth_arrest0.63137674
119MP0002693_abnormal_pancreas_physiology0.60659941
120MP0005076_abnormal_cell_differentiation0.60155369
121MP0005390_skeleton_phenotype0.59438274
122MP0002080_prenatal_lethality0.57791134
123MP0002086_abnormal_extraembryonic_tissu0.56342805
124MP0002075_abnormal_coat/hair_pigmentati0.55608100
125MP0003656_abnormal_erythrocyte_physiolo0.54883912
126MP0004264_abnormal_extraembryonic_tissu0.51836884
127MP0000343_altered_response_to0.51527240
128MP0004197_abnormal_fetal_growth/weight/0.51250420
129MP0008877_abnormal_DNA_methylation0.50660877
130MP0003567_abnormal_fetal_cardiomyocyte0.49647042
131MP0002132_abnormal_respiratory_system0.49454165
132MP0003566_abnormal_cell_adhesion0.49290574
133MP0005621_abnormal_cell_physiology0.48995195

Predicted human phenotypes

RankGene SetZ-score
1Thrombocytosis (HP:0001894)4.80142014
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.27923931
3IgM deficiency (HP:0002850)4.24249392
4Chronic otitis media (HP:0000389)4.02103784
5Chromsome breakage (HP:0040012)3.98147224
6B lymphocytopenia (HP:0010976)3.93886494
7Abnormality of B cell number (HP:0010975)3.93886494
8Panhypogammaglobulinemia (HP:0003139)3.75148278
9Recurrent viral infections (HP:0004429)3.73311040
10Nephroblastoma (Wilms tumor) (HP:0002667)3.60984844
11Myositis (HP:0100614)3.59798674
12T lymphocytopenia (HP:0005403)3.59445313
13Recurrent bronchitis (HP:0002837)3.57140495
14Abnormality of T cells (HP:0002843)3.51891033
15Abnormal delayed hypersensitivity skin test (HP:0002963)3.51000441
16Elevated erythrocyte sedimentation rate (HP:0003565)3.48329554
17Abnormality of chromosome stability (HP:0003220)3.41716441
18Embryonal renal neoplasm (HP:0011794)3.41662447
19Abnormality of T cell number (HP:0011839)3.34653588
20Recurrent fungal infections (HP:0002841)3.34174604
21Abnormality of T cell physiology (HP:0011840)3.30516867
22Aplastic anemia (HP:0001915)3.24728830
23Recurrent abscess formation (HP:0002722)3.14955806
24Eczematoid dermatitis (HP:0000976)3.13243741
25Abnormality of the fingertips (HP:0001211)3.12212315
26Meningitis (HP:0001287)3.10880285
27Irregular epiphyses (HP:0010582)2.90119576
28IgG deficiency (HP:0004315)2.89407472
29Abnormal number of erythroid precursors (HP:0012131)2.88594405
30Abnormality of cells of the erythroid lineage (HP:0012130)2.87351527
31Acute myeloid leukemia (HP:0004808)2.85066815
32Reticulocytopenia (HP:0001896)2.82807764
33Thyroiditis (HP:0100646)2.80171177
34Spastic diplegia (HP:0001264)2.79486328
35Rhabdomyosarcoma (HP:0002859)2.77532906
36Severe combined immunodeficiency (HP:0004430)2.77398813
37Abnormality of the preputium (HP:0100587)2.76846461
38Recurrent bacterial skin infections (HP:0005406)2.76824439
39Prolonged bleeding time (HP:0003010)2.76330515
40Medulloblastoma (HP:0002885)2.71986868
41Epiphyseal dysplasia (HP:0002656)2.70773011
42Birth length less than 3rd percentile (HP:0003561)2.68888018
43Hypoplasia of the thymus (HP:0000778)2.67581893
44Cellulitis (HP:0100658)2.67515853
45Petechiae (HP:0000967)2.65739332
46Granulocytopenia (HP:0001913)2.65588832
47Eosinophilia (HP:0001880)2.64481841
48Nasal polyposis (HP:0100582)2.62773458
49Autoimmune hemolytic anemia (HP:0001890)2.59713231
5011 pairs of ribs (HP:0000878)2.58367451
51Multiple enchondromatosis (HP:0005701)2.57423313
52Meckel diverticulum (HP:0002245)2.55446758
53Pancreatic islet-cell hyperplasia (HP:0004510)2.50555496
54Myelodysplasia (HP:0002863)2.50487194
55Chest pain (HP:0100749)2.49627836
56Recurrent cutaneous fungal infections (HP:0011370)2.48874602
57Chronic mucocutaneous candidiasis (HP:0002728)2.48874602
58Lymphoma (HP:0002665)2.47913547
59Lymphopenia (HP:0001888)2.44881729
60Obstructive lung disease (HP:0006536)2.44768760
61Chronic obstructive pulmonary disease (HP:0006510)2.44768760
62Combined immunodeficiency (HP:0005387)2.42135791
63Abnormality of eosinophils (HP:0001879)2.40071613
64Abnormality of the ileum (HP:0001549)2.39801643
65Amaurosis fugax (HP:0100576)2.39776996
66Agammaglobulinemia (HP:0004432)2.39772064
67Mediastinal lymphadenopathy (HP:0100721)2.38779614
68Abnormality of cells of the lymphoid lineage (HP:0012140)2.38378068
69Abnormality of the prostate (HP:0008775)2.38321183
70Agnosia (HP:0010524)2.37806117
71Epistaxis (HP:0000421)2.36602549
72Aplasia/Hypoplasia of the uvula (HP:0010293)2.35702504
73Abnormal lung lobation (HP:0002101)2.35289360
74Impaired platelet aggregation (HP:0003540)2.34733807
75Abnormal platelet function (HP:0011869)2.34733807
76Increased IgE level (HP:0003212)2.34303963
77Spontaneous hematomas (HP:0007420)2.32506343
78Small intestinal stenosis (HP:0012848)2.30820727
79Duodenal stenosis (HP:0100867)2.30820727
80Selective tooth agenesis (HP:0001592)2.27986624
81Abnormal foot bone ossification (HP:0010675)2.26626192
82Papilledema (HP:0001085)2.26057820
83Progressive external ophthalmoplegia (HP:0000590)2.25729190
84Gastrointestinal inflammation (HP:0004386)2.24645977
85Encephalitis (HP:0002383)2.24120460
86Abnormality of the nasal mucosa (HP:0000433)2.24078073
87Poikiloderma (HP:0001029)2.21182822
88Inflammation of the large intestine (HP:0002037)2.21148181
89Acute lymphatic leukemia (HP:0006721)2.19480402
90Deep philtrum (HP:0002002)2.18273199
91Short middle phalanx of the 5th finger (HP:0004220)2.17343642
92Recurrent skin infections (HP:0001581)2.16905517
93Gastrointestinal carcinoma (HP:0002672)2.16902720
94Malignant gastrointestinal tract tumors (HP:0006749)2.16902720
95Leukocytosis (HP:0001974)2.15014223
96Basal cell carcinoma (HP:0002671)2.15011453
97Volvulus (HP:0002580)2.14710146
98Increased nuchal translucency (HP:0010880)2.12632284
99Entropion (HP:0000621)2.09152581
100Small epiphyses (HP:0010585)2.09079419
101Carpal bone hypoplasia (HP:0001498)2.09007603
102Vasculitis (HP:0002633)2.06162731
103Orchitis (HP:0100796)2.04856812
104Cellular immunodeficiency (HP:0005374)2.03638287
105Periodontitis (HP:0000704)2.01958519
106Thoracolumbar scoliosis (HP:0002944)2.01910168
107Arterial thrombosis (HP:0004420)2.00870280
108Colon cancer (HP:0003003)2.00333116
109Neoplasm of the colon (HP:0100273)1.98479109
110Retrobulbar optic neuritis (HP:0100654)1.97950487
111Optic neuritis (HP:0100653)1.97950487
112IgA deficiency (HP:0002720)1.97830665
113Cortical dysplasia (HP:0002539)1.97724885
114Increased mean platelet volume (HP:0011877)1.97651362
115Microvesicular hepatic steatosis (HP:0001414)1.97256905
116Proximal placement of thumb (HP:0009623)1.96221215
117Long clavicles (HP:0000890)1.95914138
118Bronchitis (HP:0012387)1.94746924
119Abnormality of the duodenum (HP:0002246)1.94373475
120Chronic sinusitis (HP:0011109)1.94138700
121Viral hepatitis (HP:0006562)1.94051846
122Papillary thyroid carcinoma (HP:0002895)1.93711816
123Embryonal neoplasm (HP:0002898)1.93415813
124Deviation of the thumb (HP:0009603)1.92897294
125Aplasia/Hypoplasia of the sacrum (HP:0008517)1.91947456
126Abnormal platelet volume (HP:0011876)1.90781305
127Broad palm (HP:0001169)1.90685977
128Abnormality of the thoracic spine (HP:0100711)1.90394185
129Abnormality of methionine metabolism (HP:0010901)1.89607806
130Leiomyosarcoma (HP:0100243)1.89283391
131Uterine leiomyosarcoma (HP:0002891)1.89283391
132Prominent nose (HP:0000448)1.88939422
133Aplasia/Hypoplasia of the thymus (HP:0010515)1.87865232
134Type I transferrin isoform profile (HP:0003642)1.87244842
135Papilloma (HP:0012740)1.86720282
136Verrucae (HP:0200043)1.86720282
137Hemoptysis (HP:0002105)1.86399369
138Cafe-au-lait spot (HP:0000957)1.85152380
139Stomatitis (HP:0010280)1.84982001
140Abnormality of the thymus (HP:0000777)1.84851894
141Pallor (HP:0000980)1.82824154
142Transitional cell carcinoma of the bladder (HP:0006740)1.81859303
143Biliary tract neoplasm (HP:0100574)1.79872507
144Abnormality of DNA repair (HP:0003254)1.79196056
145Uterine neoplasm (HP:0010784)1.79183296
146Abnormality of homocysteine metabolism (HP:0010919)1.78832411
147Homocystinuria (HP:0002156)1.78832411
148Keratoconjunctivitis sicca (HP:0001097)1.77796583
149Anal stenosis (HP:0002025)1.76655543
150Pulmonary infiltrates (HP:0002113)1.76147466
151Thoracic kyphosis (HP:0002942)1.75623619
152Abnormality of the pancreatic islet cells (HP:0006476)1.75075467
153Abnormality of endocrine pancreas physiology (HP:0012093)1.75075467
154Clubbing of toes (HP:0100760)1.74755220
155Ovarian neoplasm (HP:0100615)1.72420474
156Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.70612189
157Stenosis of the external auditory canal (HP:0000402)1.70369024
158Absent radius (HP:0003974)1.69504526
159Neoplasm of the small intestine (HP:0100833)1.69424210
160Colitis (HP:0002583)1.69304610
161Ectopic kidney (HP:0000086)1.69041722
162Sloping forehead (HP:0000340)1.68742854
163Progressive muscle weakness (HP:0003323)1.67844311

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.30793236
2TXK3.47229185
3TTK3.03956632
4EEF2K2.78042102
5TEC2.60525349
6BTK2.58824443
7CDC72.41592200
8ZAK2.35926836
9PLK42.22094823
10JAK32.18678457
11PBK2.12715391
12IRAK42.09638742
13TAF12.06338607
14FLT32.05824613
15ZAP702.05502275
16KIT2.02020375
17PASK1.97551966
18ITK1.94112324
19SMG11.92308743
20GRK61.85222063
21PLK31.84279910
22WEE11.72737726
23STK101.69419767
24PKN21.68628939
25SYK1.67210036
26BRD41.64527551
27NEK11.61431303
28TYK21.49707621
29RPS6KB21.47253963
30TGFBR11.41589843
31RIPK41.41403003
32EIF2AK31.37232183
33MAP3K101.35325242
34BRSK21.33798253
35FES1.31937569
36MAP2K31.31578454
37PIM11.31277109
38TAOK31.29951176
39SRPK11.29295452
40IKBKE1.28766756
41TSSK61.28310171
42NLK1.27377159
43LRRK21.26360040
44CLK11.24721745
45EIF2AK21.24565202
46NEK21.23654694
47CHEK21.23104153
48CSF1R1.21591841
49LCK1.20813921
50RPS6KA41.15965995
51ATR1.15727345
52STK161.13718370
53PLK11.13575293
54MKNK11.09884664
55HCK1.09775998
56VRK11.09041223
57VRK21.08933359
58FGFR31.08581644
59CDK41.08040022
60NME21.06752242
61TNK21.05475515
62TRIM281.04063197
63NUAK11.00823527
64SCYL20.98693417
65SIK30.97405554
66HIPK20.96778192
67STK30.96619553
68LYN0.93879708
69BMPR20.90115218
70ACVR1B0.89051738
71YES10.87159099
72TRPM70.86941090
73PRPF4B0.84344265
74JAK10.83094176
75MKNK20.80915883
76PIM20.79656912
77MAP3K140.79605592
78CDK60.77122337
79BUB10.77121250
80BMPR1B0.75289616
81CSK0.75252620
82EIF2AK10.75220542
83TBK10.74135511
84STK40.70847519
85RPS6KA60.70358452
86IRAK20.70052820
87FGR0.69737464
88IKBKB0.69502646
89TGFBR20.68999833
90MST40.67303034
91AURKB0.66379317
92FGFR40.65242156
93MAP3K120.65174424
94CDK80.64608863
95BLK0.64326185
96ALK0.64039612
97CDK70.64009611
98TNIK0.63982440
99DYRK30.63834155
100KDR0.60827909
101ERN10.60609885
102STK240.60053707
103MAP3K80.59762352
104JAK20.59381624
105CDK30.59151995
106RPS6KC10.59069945
107RPS6KL10.59069945
108MATK0.56953560
109PAK40.55537888
110CDK120.55036581
111MAP3K30.54532569
112PRKG20.54062620
113MAPK40.52974517
114CDK20.52855171
115CDK190.51740114
116IRAK10.51269180
117SIK20.50658113
118MELK0.50165026
119PTK60.49918012
120CCNB10.49546931
121FGFR10.49328651
122TESK20.48705009
123BRAF0.48399059
124CHUK0.46852741
125CHEK10.46098926
126BMX0.45602932
127ERBB40.43919708
128RPS6KB10.43736303
129IRAK30.43499550
130ATM0.42939695
131CDK10.42561569
132MARK30.41104533
133CDK90.39890382
134DAPK10.38623691
135MAPK110.38315955
136MAPK30.38001092
137BRSK10.37879987
138CSNK2A20.37458173

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.84218668
2Primary immunodeficiency_Homo sapiens_hsa053403.35931510
3Mismatch repair_Homo sapiens_hsa034302.89086988
4Ribosome_Homo sapiens_hsa030102.64186775
5Base excision repair_Homo sapiens_hsa034102.36739224
6Non-homologous end-joining_Homo sapiens_hsa034502.32426819
7Antigen processing and presentation_Homo sapiens_hsa046122.23353812
8Spliceosome_Homo sapiens_hsa030402.08550973
9Homologous recombination_Homo sapiens_hsa034401.92455511
10Nucleotide excision repair_Homo sapiens_hsa034201.90545019
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.85298694
12Leishmaniasis_Homo sapiens_hsa051401.77123002
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.76094303
14Measles_Homo sapiens_hsa051621.75583945
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.74275622
16Cell cycle_Homo sapiens_hsa041101.69494035
17B cell receptor signaling pathway_Homo sapiens_hsa046621.67729429
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.64412416
19T cell receptor signaling pathway_Homo sapiens_hsa046601.62418784
20Hematopoietic cell lineage_Homo sapiens_hsa046401.57743851
21Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.51195116
22Herpes simplex infection_Homo sapiens_hsa051681.51020054
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.46486543
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.45157403
25RNA degradation_Homo sapiens_hsa030181.43200926
26Fanconi anemia pathway_Homo sapiens_hsa034601.39065215
27RNA transport_Homo sapiens_hsa030131.35171183
28Protein export_Homo sapiens_hsa030601.33104581
29Osteoclast differentiation_Homo sapiens_hsa043801.32711382
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.31204371
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.26720000
32Pyrimidine metabolism_Homo sapiens_hsa002401.26051703
33Transcriptional misregulation in cancer_Homo sapiens_hsa052021.26028335
34N-Glycan biosynthesis_Homo sapiens_hsa005101.24844753
35Allograft rejection_Homo sapiens_hsa053301.24179800
36Jak-STAT signaling pathway_Homo sapiens_hsa046301.21161988
37Hepatitis B_Homo sapiens_hsa051611.20032382
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.19142096
39One carbon pool by folate_Homo sapiens_hsa006701.15193822
40Acute myeloid leukemia_Homo sapiens_hsa052211.12214145
41Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.07341456
42NOD-like receptor signaling pathway_Homo sapiens_hsa046211.06278239
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.04768746
44RNA polymerase_Homo sapiens_hsa030201.01374505
45HTLV-I infection_Homo sapiens_hsa051660.99725209
46Viral carcinogenesis_Homo sapiens_hsa052030.99579469
47Biosynthesis of amino acids_Homo sapiens_hsa012300.98963216
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.98818058
49Chronic myeloid leukemia_Homo sapiens_hsa052200.98492484
50Platelet activation_Homo sapiens_hsa046110.98265507
51Thyroid cancer_Homo sapiens_hsa052160.98081781
52mRNA surveillance pathway_Homo sapiens_hsa030150.96017504
53p53 signaling pathway_Homo sapiens_hsa041150.95416256
54Legionellosis_Homo sapiens_hsa051340.95303166
55Asthma_Homo sapiens_hsa053100.94157715
56Epstein-Barr virus infection_Homo sapiens_hsa051690.92982963
57Toxoplasmosis_Homo sapiens_hsa051450.91042458
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.89779023
59Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.89400231
60Graft-versus-host disease_Homo sapiens_hsa053320.88974680
61Selenocompound metabolism_Homo sapiens_hsa004500.87964759
62Shigellosis_Homo sapiens_hsa051310.84820757
63Leukocyte transendothelial migration_Homo sapiens_hsa046700.83605106
64Apoptosis_Homo sapiens_hsa042100.83297828
65Chemokine signaling pathway_Homo sapiens_hsa040620.81270837
66Non-small cell lung cancer_Homo sapiens_hsa052230.80811371
67Influenza A_Homo sapiens_hsa051640.80044283
68Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.78939370
69Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.78834692
70Toll-like receptor signaling pathway_Homo sapiens_hsa046200.76607692
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76460601
72Systemic lupus erythematosus_Homo sapiens_hsa053220.75166999
73Other glycan degradation_Homo sapiens_hsa005110.73761879
74Pancreatic cancer_Homo sapiens_hsa052120.72352288
75Basal transcription factors_Homo sapiens_hsa030220.71433445
76Purine metabolism_Homo sapiens_hsa002300.70698613
77Carbon metabolism_Homo sapiens_hsa012000.69873224
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.68200667
79Type I diabetes mellitus_Homo sapiens_hsa049400.67388179
80Viral myocarditis_Homo sapiens_hsa054160.66262664
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65593561
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.65554268
83Small cell lung cancer_Homo sapiens_hsa052220.65253732
84Proteasome_Homo sapiens_hsa030500.64847559
85Prostate cancer_Homo sapiens_hsa052150.64773944
86TNF signaling pathway_Homo sapiens_hsa046680.64760677
87Colorectal cancer_Homo sapiens_hsa052100.63545678
88Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63016070
89Autoimmune thyroid disease_Homo sapiens_hsa053200.61557399
90Tuberculosis_Homo sapiens_hsa051520.57671481
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57390600
92Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.57098931
93Oocyte meiosis_Homo sapiens_hsa041140.54945656
94Pertussis_Homo sapiens_hsa051330.54591224
95Pentose phosphate pathway_Homo sapiens_hsa000300.51949074
96AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50053688
97Steroid biosynthesis_Homo sapiens_hsa001000.49221473
98Endometrial cancer_Homo sapiens_hsa052130.49214136
99Malaria_Homo sapiens_hsa051440.48015202
100Prolactin signaling pathway_Homo sapiens_hsa049170.45145601
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43326872
102Adherens junction_Homo sapiens_hsa045200.42026565
103Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40521220
104Propanoate metabolism_Homo sapiens_hsa006400.40248572
105Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39797064
106Bladder cancer_Homo sapiens_hsa052190.39786262
107TGF-beta signaling pathway_Homo sapiens_hsa043500.39239337
108Pyruvate metabolism_Homo sapiens_hsa006200.39083538
109Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38707091
110Hepatitis C_Homo sapiens_hsa051600.37364351
111Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37315611
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36983708
113SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36902105
1142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.36632916
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36623277
116HIF-1 signaling pathway_Homo sapiens_hsa040660.34712131
117MicroRNAs in cancer_Homo sapiens_hsa052060.34463388
118Salmonella infection_Homo sapiens_hsa051320.33969607
119Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33218417
120VEGF signaling pathway_Homo sapiens_hsa043700.33027690
121Alcoholism_Homo sapiens_hsa050340.32592851
122Lysine degradation_Homo sapiens_hsa003100.30129283

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