STEAP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a multipass membrane protein that functions as an iron transporter. The encoded protein can reduce both iron (Fe3+) and copper (Cu2+) cations. This protein may mediate downstream responses to p53, including promoting apoptosis. Deficiency in this gene can cause anemia. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX metabolic process (GO:0046501)5.94219112
2protoporphyrinogen IX biosynthetic process (GO:0006782)5.55616243
3heme biosynthetic process (GO:0006783)5.39535951
4fibrinolysis (GO:0042730)5.12687801
5porphyrin-containing compound biosynthetic process (GO:0006779)4.91172806
6negative regulation of fibrinolysis (GO:0051918)4.84772435
7regulation of fibrinolysis (GO:0051917)4.65313742
8heme metabolic process (GO:0042168)4.50153678
9tetrapyrrole biosynthetic process (GO:0033014)4.38369201
10exogenous drug catabolic process (GO:0042738)4.30968069
11ethanol metabolic process (GO:0006067)4.30103227
12epoxygenase P450 pathway (GO:0019373)4.28426062
13omega-hydroxylase P450 pathway (GO:0097267)4.17796518
14ethanol oxidation (GO:0006069)4.17565633
15porphyrin-containing compound metabolic process (GO:0006778)4.08290496
16L-phenylalanine metabolic process (GO:0006558)4.05994781
17erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.05994781
18urea metabolic process (GO:0019627)4.05785378
19primary alcohol catabolic process (GO:0034310)4.03142498
20Golgi transport vesicle coating (GO:0048200)4.01284338
21COPI coating of Golgi vesicle (GO:0048205)4.01284338
22protein heterotrimerization (GO:0070208)3.88005380
23lysine metabolic process (GO:0006553)3.87363379
24lysine catabolic process (GO:0006554)3.87363379
25regulation of apoptotic cell clearance (GO:2000425)3.83357260
26drug catabolic process (GO:0042737)3.74922660
27barbed-end actin filament capping (GO:0051016)3.73207867
28urea cycle (GO:0000050)3.68489070
29axonemal dynein complex assembly (GO:0070286)3.63612231
30regulation of plasminogen activation (GO:0010755)3.63050002
31nitrogen cycle metabolic process (GO:0071941)3.62778874
32low-density lipoprotein particle clearance (GO:0034383)3.57249849
33regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.56408102
34cell adhesion mediated by integrin (GO:0033627)3.55844344
35folic acid metabolic process (GO:0046655)3.55589320
36protein localization to endosome (GO:0036010)3.55268070
37erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.45455495
38L-phenylalanine catabolic process (GO:0006559)3.45455495
39maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.43304665
40regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.41311045
41negative regulation of blood coagulation (GO:0030195)3.36517135
42negative regulation of hemostasis (GO:1900047)3.36517135
43protein retention in ER lumen (GO:0006621)3.35342639
44keratan sulfate catabolic process (GO:0042340)3.32730849
45negative regulation of coagulation (GO:0050819)3.25734036
46dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.25699283
47folic acid-containing compound biosynthetic process (GO:0009396)3.19763061
48negative regulation of wound healing (GO:0061045)3.14530699
49maternal placenta development (GO:0001893)3.11473680
50hemidesmosome assembly (GO:0031581)3.10877565
51valine metabolic process (GO:0006573)3.09087728
52acute-phase response (GO:0006953)3.08484303
53erythrocyte maturation (GO:0043249)3.05801075
54positive regulation of lipoprotein lipase activity (GO:0051006)3.04819875
55positive regulation of triglyceride lipase activity (GO:0061365)3.04819875
56regulation of cholesterol storage (GO:0010885)3.01047762
57DNA deamination (GO:0045006)3.01009578
58cellular glucuronidation (GO:0052695)2.99277426
59oxaloacetate metabolic process (GO:0006107)2.99143546
60pentose-phosphate shunt (GO:0006098)2.97385974
612-oxoglutarate metabolic process (GO:0006103)2.96733297
62positive regulation of hemostasis (GO:1900048)2.95757466
63positive regulation of blood coagulation (GO:0030194)2.95757466
64glyoxylate metabolic process (GO:0046487)2.93557831
65folic acid transport (GO:0015884)2.89778158
66negative regulation of sterol transport (GO:0032372)2.85917865
67negative regulation of cholesterol transport (GO:0032375)2.85917865
68regulation of complement activation (GO:0030449)2.85093282
69positive regulation of coagulation (GO:0050820)2.83938393
70collagen fibril organization (GO:0030199)2.83041986
71positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.82514227
72NADH metabolic process (GO:0006734)2.82240647
73regulation of sequestering of triglyceride (GO:0010889)2.82165986
74hypotonic response (GO:0006971)2.81340272
75drug metabolic process (GO:0017144)2.81016346
76uronic acid metabolic process (GO:0006063)2.80821718
77glucuronate metabolic process (GO:0019585)2.80821718
78bile acid biosynthetic process (GO:0006699)2.80694198
79tetrapyrrole metabolic process (GO:0033013)2.80528681
80positive regulation of triglyceride biosynthetic process (GO:0010867)2.79862321
81regulation of protein activation cascade (GO:2000257)2.78978159
82motile cilium assembly (GO:0044458)2.77556943
83pinocytosis (GO:0006907)2.76682779
84gas transport (GO:0015669)2.76517706
85skin morphogenesis (GO:0043589)2.74944726
86positive regulation of fatty acid beta-oxidation (GO:0032000)2.72878613
87pigment biosynthetic process (GO:0046148)2.72228586
88tricarboxylic acid cycle (GO:0006099)2.72129571
89protein activation cascade (GO:0072376)2.71707558
90complement activation, alternative pathway (GO:0006957)2.71611290
91IMP biosynthetic process (GO:0006188)2.71528927
92regulation of metalloenzyme activity (GO:0048552)2.71423950
93alpha-linolenic acid metabolic process (GO:0036109)2.70386013
94glycine metabolic process (GO:0006544)2.70204732
95basement membrane organization (GO:0071711)2.69464747
96proline biosynthetic process (GO:0006561)2.69392305
97carnitine metabolic process (GO:0009437)2.69014537
98amino-acid betaine metabolic process (GO:0006577)2.67902647
99adhesion of symbiont to host (GO:0044406)2.67744607
100hyaluronan catabolic process (GO:0030214)2.67718737
101polyketide metabolic process (GO:0030638)2.67319143
102doxorubicin metabolic process (GO:0044598)2.67319143
103daunorubicin metabolic process (GO:0044597)2.67319143
104epithelial cell-cell adhesion (GO:0090136)2.66485738
105proline metabolic process (GO:0006560)2.66442421
106erythrocyte development (GO:0048821)2.66397083
107negative regulation of lipid transport (GO:0032369)2.66362375
108regulation of fatty acid beta-oxidation (GO:0031998)2.65946701
109NADPH regeneration (GO:0006740)2.65563683
110adhesion of symbiont to host cell (GO:0044650)2.65380409
111virion attachment to host cell (GO:0019062)2.65380409
112complement activation (GO:0006956)2.64630906
113complement activation, classical pathway (GO:0006958)2.64491707
114negative regulation of fatty acid biosynthetic process (GO:0045717)2.64106122
115cysteine metabolic process (GO:0006534)2.62737061
116negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.61457201
117glycosphingolipid catabolic process (GO:0046479)2.60787069
118cell-substrate junction assembly (GO:0007044)2.60528216
119one-carbon compound transport (GO:0019755)2.59734899
120regulation of glucose import in response to insulin stimulus (GO:2001273)2.59591036
121tricarboxylic acid metabolic process (GO:0072350)2.58964841
122fat-soluble vitamin biosynthetic process (GO:0042362)2.58077905
123regulation of extracellular matrix organization (GO:1903053)2.57767360
124bile acid metabolic process (GO:0008206)2.57700226
125positive regulation of triglyceride metabolic process (GO:0090208)2.57510607
126cellular response to zinc ion (GO:0071294)2.57479637
127triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.55253111
128hyaluronan metabolic process (GO:0030212)2.55141785
129regulation of fatty acid oxidation (GO:0046320)2.54891193
130DNA strand elongation involved in DNA replication (GO:0006271)2.54050619
131cellular response to cadmium ion (GO:0071276)2.52887706
132peptidyl-glutamic acid carboxylation (GO:0017187)2.52772249
133protein carboxylation (GO:0018214)2.52772249
134apoptotic cell clearance (GO:0043277)2.51928384
135protein maturation by protein folding (GO:0022417)2.51498887
136protein autoprocessing (GO:0016540)2.51320574
137aspartate family amino acid biosynthetic process (GO:0009067)2.50840220
138negative regulation of lipase activity (GO:0060192)2.50356795
139negative regulation of protein activation cascade (GO:2000258)2.50222774
140embryo implantation (GO:0007566)2.50152418
141desmosome organization (GO:0002934)2.50141565
142plasma membrane repair (GO:0001778)2.49878362
143positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.49821238
144purine nucleotide salvage (GO:0032261)2.49426861
145positive regulation of fatty acid biosynthetic process (GO:0045723)2.48750680
146regulation of humoral immune response (GO:0002920)2.48428203
147plasma lipoprotein particle clearance (GO:0034381)2.47643245
148regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.46216362
149fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.46026825
150cellular response to arsenic-containing substance (GO:0071243)2.45527650
151glucose catabolic process (GO:0006007)2.44614676
152positive regulation of extracellular matrix organization (GO:1903055)2.44331277
153fatty acid beta-oxidation (GO:0006635)2.43949280
154DNA replication initiation (GO:0006270)2.43212451
155endodermal cell differentiation (GO:0035987)2.43209208
156response to thyroid hormone (GO:0097066)2.42177172
157positive regulation of fatty acid oxidation (GO:0046321)2.41301577
158aspartate family amino acid catabolic process (GO:0009068)2.41156898
159fatty acid transmembrane transport (GO:1902001)2.40509169
160ADP metabolic process (GO:0046031)2.40403054
161heme transport (GO:0015886)2.39909938
162telomere maintenance via semi-conservative replication (GO:0032201)2.39820704
163IMP metabolic process (GO:0046040)2.38148337
164collagen metabolic process (GO:0032963)2.36786773
165DNA strand elongation (GO:0022616)2.35709288
166biotin metabolic process (GO:0006768)2.35612369
167pigment metabolic process (GO:0042440)2.35405520
168folic acid-containing compound metabolic process (GO:0006760)2.34541725
169collagen catabolic process (GO:0030574)2.32908225
170positive regulation of lipid storage (GO:0010884)2.32005901
171AMP metabolic process (GO:0046033)2.30965049
172aspartate family amino acid metabolic process (GO:0009066)2.29626546
173galactose catabolic process (GO:0019388)2.28683480
174sulfur amino acid catabolic process (GO:0000098)2.27764304
175nucleoside salvage (GO:0043174)2.27075878
176serine family amino acid biosynthetic process (GO:0009070)2.24635995
177cellular response to thyroid hormone stimulus (GO:0097067)2.23654443
178regulation of triglyceride biosynthetic process (GO:0010866)2.23366478
179response to lead ion (GO:0010288)2.22740268
180carnitine shuttle (GO:0006853)2.22638614
181purine-containing compound salvage (GO:0043101)2.22602590
182organ regeneration (GO:0031100)2.22139646
183response to arsenic-containing substance (GO:0046685)2.21673838
184DNA replication checkpoint (GO:0000076)2.21231406
185DNA unwinding involved in DNA replication (GO:0006268)2.20983270

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.08015415
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.48163782
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.25836994
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.84805504
5FOXM1_23109430_ChIP-Seq_U2OS_Human2.65360420
6MYC_18555785_ChIP-Seq_MESCs_Mouse2.51932377
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.46379452
8* RXR_22158963_ChIP-Seq_LIVER_Mouse2.38335384
9TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.36223569
10* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.33303832
11ESR2_21235772_ChIP-Seq_MCF-7_Human2.25075055
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.22276340
13GATA1_22025678_ChIP-Seq_K562_Human1.96202334
14SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.93584958
15RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.89836574
16AR_21909140_ChIP-Seq_LNCAP_Human1.89518317
17CLOCK_20551151_ChIP-Seq_293T_Human1.84139188
18MYC_18358816_ChIP-ChIP_MESCs_Mouse1.83011719
19KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.80225394
20ZNF263_19887448_ChIP-Seq_K562_Human1.75610539
21TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71996379
22CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.70796037
23ESR1_21235772_ChIP-Seq_MCF-7_Human1.69800952
24EGR1_19374776_ChIP-ChIP_THP-1_Human1.66810601
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.60566649
26VDR_21846776_ChIP-Seq_THP-1_Human1.60541280
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.59727288
28STAT3_1855785_ChIP-Seq_MESCs_Mouse1.58720495
29GATA1_22383799_ChIP-Seq_G1ME_Mouse1.58431642
30* LXR_22158963_ChIP-Seq_LIVER_Mouse1.58076940
31TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.57960237
32MYC_19079543_ChIP-ChIP_MESCs_Mouse1.56968206
33ETS1_20019798_ChIP-Seq_JURKAT_Human1.56800357
34* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.56477923
35HIF1A_21447827_ChIP-Seq_MCF-7_Human1.56405523
36E2F4_17652178_ChIP-ChIP_JURKAT_Human1.56255918
37MYC_22102868_ChIP-Seq_BL_Human1.55615645
38* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.55314367
39JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.55032648
40SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.54947283
41* ELK3_25401928_ChIP-Seq_HUVEC_Human1.52838002
42SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.51930160
43SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.51930160
44MYC_19030024_ChIP-ChIP_MESCs_Mouse1.49213354
45CREB1_15753290_ChIP-ChIP_HEK293T_Human1.48540278
46PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.47772328
47* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.45332090
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.44542195
49P300_27058665_Chip-Seq_ZR-75-30cells_Human1.44488671
50NELFA_20434984_ChIP-Seq_ESCs_Mouse1.44100093
51MYB_21317192_ChIP-Seq_ERMYB_Mouse1.44050201
52SCL_19346495_ChIP-Seq_HPC-7_Human1.43430835
53* GATA1_19941827_ChIP-Seq_MEL_Mouse1.42685471
54STAT6_21828071_ChIP-Seq_BEAS2B_Human1.42179484
55GATA1_19941826_ChIP-Seq_K562_Human1.41077766
56UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.39128514
57CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.37229312
58ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.36936704
59TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36773090
60TRIM28_21343339_ChIP-Seq_HEK293_Human1.36122019
61* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.35116587
62TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.31944532
63P63_26484246_Chip-Seq_KERATINOCYTES_Human1.31780794
64TFEB_21752829_ChIP-Seq_HELA_Human1.31078952
65KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.30987767
66EGR1_23403033_ChIP-Seq_LIVER_Mouse1.30800795
67UBF1/2_26484160_Chip-Seq_HMECs_Human1.30174052
68SOX2_27498859_Chip-Seq_STOMACH_Mouse1.29611132
69XRN2_22483619_ChIP-Seq_HELA_Human1.29162889
70RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.29022596
71NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.28211408
72HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.26122460
73* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.26066362
74CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.25514739
75SRF_21415370_ChIP-Seq_HL-1_Mouse1.25044637
76ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.24414833
77* ATF3_27146783_Chip-Seq_COLON_Human1.23525792
78* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22079603
79KDM2B_26808549_Chip-Seq_SUP-B15_Human1.21167774
80EST1_17652178_ChIP-ChIP_JURKAT_Human1.21076483
81DCP1A_22483619_ChIP-Seq_HELA_Human1.21003192
82THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20785155
83SRY_22984422_ChIP-ChIP_TESTIS_Rat1.20382359
84PPAR_26484153_Chip-Seq_NCI-H1993_Human1.18361494
85ESR1_20079471_ChIP-ChIP_T-47D_Human1.18345606
86* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.18288529
87E2F1_21310950_ChIP-Seq_MCF-7_Human1.18058216
88* TP53_22127205_ChIP-Seq_IMR90_Human1.16048278
89SOX9_24532713_ChIP-Seq_HFSC_Mouse1.15191441
90Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.14072682
91* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.13397075
92ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.12759539
93FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.11576841
94HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.11546495
95RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.10993883
96ZFX_18555785_ChIP-Seq_MESCs_Mouse1.10939100
97TBX20_22328084_ChIP-Seq_HEART_Mouse1.09368542
98TBX20_22080862_ChIP-Seq_HEART_Mouse1.09368542
99CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09316167
100NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07545416
101MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.06799818
102SOX2_20726797_ChIP-Seq_SW620_Human1.05287344
103* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.05016114
104KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04590249
105ELF1_17652178_ChIP-ChIP_JURKAT_Human1.03422522
106GABP_17652178_ChIP-ChIP_JURKAT_Human1.03294724
107GABP_19822575_ChIP-Seq_HepG2_Human1.02972603
108LXR_22292898_ChIP-Seq_THP-1_Human1.02739941
109TET1_21451524_ChIP-Seq_MESCs_Mouse1.02718538
110SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.02178721
111CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.01461625
112ESR1_15608294_ChIP-ChIP_MCF-7_Human1.00265962
113FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.99744592
114DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99509279
115NANOG_18555785_ChIP-Seq_MESCs_Mouse0.99478210
116WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99373106
117RUNX1_27514584_Chip-Seq_MCF-7_Human0.98674151
118SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98245385
119TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.98174352
120ELF1_20517297_ChIP-Seq_JURKAT_Human0.97968293
121* SMC4_20622854_ChIP-Seq_HELA_Human0.97380828
122TCF7_22412390_ChIP-Seq_EML_Mouse0.97343857
123KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.96849235
124NCOR1_26117541_ChIP-Seq_K562_Human0.96830675
125VDR_23849224_ChIP-Seq_CD4+_Human0.96749131
126RACK7_27058665_Chip-Seq_MCF-7_Human0.96327545
127KDM2B_26808549_Chip-Seq_K562_Human0.96092650
128PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96034182
129NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.95859848
130GATA2_21666600_ChIP-Seq_HMVEC_Human0.95574219
131* GATA4_21415370_ChIP-Seq_HL-1_Mouse0.94937500
132CIITA_25753668_ChIP-Seq_RAJI_Human0.94118704
133ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.94118489
134ERG_21242973_ChIP-ChIP_JURKAT_Human0.93773438
135CTCF_27219007_Chip-Seq_ERYTHROID_Human0.93769007
136ERG_20887958_ChIP-Seq_HPC-7_Mouse0.93705308
137CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.93415002
138TP63_17297297_ChIP-ChIP_HaCaT_Human0.93318560
139SA1_27219007_Chip-Seq_ERYTHROID_Human0.91956243
140VDR_24763502_ChIP-Seq_THP-1_Human0.91905107
141KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.91456136
142FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.91226418
143BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.90868627
144POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.90846737
145JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90771100
146SMC1_22415368_ChIP-Seq_MEFs_Mouse0.90168102
147MAF_26560356_Chip-Seq_TH1_Human0.90167129
148GATA2_22383799_ChIP-Seq_G1ME_Mouse0.90095224
149FOXP3_21729870_ChIP-Seq_TREG_Human0.89497945
150* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.88982116
151P68_20966046_ChIP-Seq_HELA_Human0.88961200
152* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88572334
153GATA2_19941826_ChIP-Seq_K562_Human0.88068779

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.89373326
2* MP0003656_abnormal_erythrocyte_physiolo3.74882164
3MP0005275_abnormal_skin_tensile3.65631024
4MP0005503_abnormal_tendon_morphology3.25331210
5MP0004147_increased_porphyrin_level3.18845911
6MP0003705_abnormal_hypodermis_morpholog2.98493955
7MP0008875_abnormal_xenobiotic_pharmacok2.95766459
8MP0009840_abnormal_foam_cell2.68203360
9MP0006054_spinal_hemorrhage2.52571664
10MP0005451_abnormal_body_composition2.34569008
11MP0003950_abnormal_plasma_membrane2.26066214
12MP0003806_abnormal_nucleotide_metabolis2.23903975
13MP0003279_aneurysm2.16031025
14MP0005397_hematopoietic_system_phenotyp1.96607645
15MP0001545_abnormal_hematopoietic_system1.96607645
16MP0002877_abnormal_melanocyte_morpholog1.93249016
17MP0000751_myopathy1.92860204
18MP0001958_emphysema1.90872148
19MP0001849_ear_inflammation1.84041435
20MP0002139_abnormal_hepatobiliary_system1.78624304
21MP0002837_dystrophic_cardiac_calcinosis1.73374922
22MP0000749_muscle_degeneration1.72174565
23MP0000678_abnormal_parathyroid_gland1.71320069
24MP0005360_urolithiasis1.70491880
25MP0003453_abnormal_keratinocyte_physiol1.68088529
26MP0005623_abnormal_meninges_morphology1.65066229
27MP0003091_abnormal_cell_migration1.61891363
28MP0003566_abnormal_cell_adhesion1.60274169
29MP0002396_abnormal_hematopoietic_system1.60193854
30MP0003191_abnormal_cellular_cholesterol1.60104117
31MP0005670_abnormal_white_adipose1.59840593
32MP0000750_abnormal_muscle_regeneration1.51097248
33MP0003111_abnormal_nucleus_morphology1.50897746
34MP0009780_abnormal_chondrocyte_physiolo1.45552747
35MP0003195_calcinosis1.43110737
36MP0005058_abnormal_lysosome_morphology1.42999562
37MP0003186_abnormal_redox_activity1.42593940
38MP0003646_muscle_fatigue1.42502312
39MP0004130_abnormal_muscle_cell1.41725989
40MP0004233_abnormal_muscle_weight1.41629220
41MP0008775_abnormal_heart_ventricle1.40658031
42MP0003075_altered_response_to1.40564409
43MP0002060_abnormal_skin_morphology1.39843533
44MP0004215_abnormal_myocardial_fiber1.39768735
45MP0004510_myositis1.38506233
46MP0002896_abnormal_bone_mineralization1.37922881
47MP0005330_cardiomyopathy1.35007269
48MP0004084_abnormal_cardiac_muscle1.32818903
49MP0005023_abnormal_wound_healing1.32720958
50MP0005257_abnormal_intraocular_pressure1.29729605
51MP0005076_abnormal_cell_differentiation1.29687416
52MP0005165_increased_susceptibility_to1.29558193
53MP0010329_abnormal_lipoprotein_level1.29331588
54MP0001243_abnormal_dermal_layer1.29053041
55MP0005083_abnormal_biliary_tract1.25856282
56MP0003941_abnormal_skin_development1.23303610
57MP0010307_abnormal_tumor_latency1.21003264
58MP0003868_abnormal_feces_composition1.20621359
59MP0002108_abnormal_muscle_morphology1.19487032
60MP0001542_abnormal_bone_strength1.18079308
61MP0002269_muscular_atrophy1.17698947
62MP0000343_altered_response_to1.17536970
63MP0005164_abnormal_response_to1.17112120
64MP0005365_abnormal_bile_salt1.13867562
65MP0003693_abnormal_embryo_hatching1.13287367
66MP0005319_abnormal_enzyme/_coenzyme1.12764198
67MP0003436_decreased_susceptibility_to1.12400871
68MP0009053_abnormal_anal_canal1.12355573
69MP0006036_abnormal_mitochondrial_physio1.11126250
70MP0010234_abnormal_vibrissa_follicle1.09799186
71MP0002168_other_aberrant_phenotype1.08896066
72MP0000747_muscle_weakness1.08156873
73MP0005666_abnormal_adipose_tissue1.07624692
74MP0010352_gastrointestinal_tract_polyps1.07187645
75MP0004087_abnormal_muscle_fiber1.07159661
76MP0001666_abnormal_nutrient_absorption1.06884058
77* MP0000609_abnormal_liver_physiology1.05799859
78MP0000604_amyloidosis1.05293891
79MP0008260_abnormal_autophagy1.05125838
80MP0002332_abnormal_exercise_endurance1.03949713
81MP0005085_abnormal_gallbladder_physiolo1.03926814
82MP0003172_abnormal_lysosome_physiology1.03881767
83MP0010030_abnormal_orbit_morphology1.03330768
84MP0003300_gastrointestinal_ulcer0.97654275
85MP0002998_abnormal_bone_remodeling0.97093495
86MP0005508_abnormal_skeleton_morphology0.96209895
87MP0004272_abnormal_basement_membrane0.95567065
88MP0001661_extended_life_span0.93664416
89MP0002132_abnormal_respiratory_system0.93456260
90MP0002796_impaired_skin_barrier0.92780651
91MP0005332_abnormal_amino_acid0.90774561
92MP0001544_abnormal_cardiovascular_syste0.90596483
93MP0005385_cardiovascular_system_phenoty0.90596483
94MP0010368_abnormal_lymphatic_system0.90520962
95MP0000598_abnormal_liver_morphology0.90255627
96MP0003252_abnormal_bile_duct0.88473030
97MP0009278_abnormal_bone_marrow0.88263409
98MP0000759_abnormal_skeletal_muscle0.88077988
99MP0010630_abnormal_cardiac_muscle0.88016992
100MP0002933_joint_inflammation0.87812653
101MP0004858_abnormal_nervous_system0.87696191
102MP0000467_abnormal_esophagus_morphology0.87269696
103MP0001853_heart_inflammation0.87084214
104MP0005375_adipose_tissue_phenotype0.85578582
105MP0009115_abnormal_fat_cell0.84357609
106MP0003448_altered_tumor_morphology0.84335376
107MP0003303_peritoneal_inflammation0.83512653
108MP0009697_abnormal_copulation0.83387134
109MP0006082_CNS_inflammation0.83347297
110MP0000490_abnormal_crypts_of0.82585519
111MP0000767_abnormal_smooth_muscle0.82476066
112MP0000733_abnormal_muscle_development0.81612394
113MP0001216_abnormal_epidermal_layer0.81321278
114MP0001533_abnormal_skeleton_physiology0.80465462
115MP0003329_amyloid_beta_deposits0.80379751
116MP0004185_abnormal_adipocyte_glucose0.79215128
117MP0005501_abnormal_skin_physiology0.78491285
118MP0003077_abnormal_cell_cycle0.78313833
119MP0009763_increased_sensitivity_to0.78207687
120MP0005166_decreased_susceptibility_to0.77930420
121MP0002970_abnormal_white_adipose0.77687231
122MP0004957_abnormal_blastocyst_morpholog0.77683685
123MP0004808_abnormal_hematopoietic_stem0.77335480
124MP0005369_muscle_phenotype0.77274563
125MP0000762_abnormal_tongue_morphology0.77139952
126MP0001915_intracranial_hemorrhage0.76517158
127MP0004782_abnormal_surfactant_physiolog0.75792697
128MP0004036_abnormal_muscle_relaxation0.75657338
129MP0005390_skeleton_phenotype0.75287423
130MP0003567_abnormal_fetal_cardiomyocyte0.74919701
131MP0002118_abnormal_lipid_homeostasis0.74154281
132MP0003221_abnormal_cardiomyocyte_apopto0.73608998
133MP0000003_abnormal_adipose_tissue0.73318388
134MP0002128_abnormal_blood_circulation0.72415023
135MP0009931_abnormal_skin_appearance0.72374415
136MP0005197_abnormal_uvea_morphology0.72109545
137MP0009643_abnormal_urine_homeostasis0.71499776
138MP0002106_abnormal_muscle_physiology0.70456688
139MP0005409_darkened_coat_color0.70449613
140MP0005464_abnormal_platelet_physiology0.69217928
141MP0003724_increased_susceptibility_to0.68815297
142MP0010094_abnormal_chromosome_stability0.67411040
143MP0005584_abnormal_enzyme/coenzyme_acti0.66800298
144MP0002089_abnormal_postnatal_growth/wei0.65103843
145MP0000358_abnormal_cell_content/0.64755481
146MP0009384_cardiac_valve_regurgitation0.64263143
147MP0000858_altered_metastatic_potential0.63980017
148MP0008469_abnormal_protein_level0.61258401

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.00898142
2Abnormality of the heme biosynthetic pathway (HP:0010472)5.63376772
3Ankle contracture (HP:0006466)5.25173312
4Premature rupture of membranes (HP:0001788)5.22716242
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.00580784
6Increased connective tissue (HP:0009025)4.06442026
7Reticulocytosis (HP:0001923)3.69173340
8Type 1 muscle fiber predominance (HP:0003803)3.59861766
9Poikilocytosis (HP:0004447)3.50532477
10Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.47080330
11Vertebral compression fractures (HP:0002953)3.44216855
12Slender build (HP:0001533)3.42297508
13Cervical subluxation (HP:0003308)3.33725127
14Nonimmune hydrops fetalis (HP:0001790)3.23701904
15Conjugated hyperbilirubinemia (HP:0002908)3.21040709
16Abnormality of aromatic amino acid family metabolism (HP:0004338)3.20153342
17Broad metatarsal (HP:0001783)3.18596286
18Short nail (HP:0001799)3.02630708
19Glomerulonephritis (HP:0000099)2.96209152
20Soft skin (HP:0000977)2.89705284
21Distal lower limb muscle weakness (HP:0009053)2.89651312
22Cardiovascular calcification (HP:0011915)2.86819910
23Biconcave vertebral bodies (HP:0004586)2.85708471
24Nausea (HP:0002018)2.83727890
25Polycythemia (HP:0001901)2.83589664
26Abnormal number of erythroid precursors (HP:0012131)2.82298341
27Abnormality of glycolipid metabolism (HP:0010969)2.81653115
28Abnormality of liposaccharide metabolism (HP:0010968)2.81653115
29Abnormality of glycosphingolipid metabolism (HP:0004343)2.81653115
30Follicular hyperkeratosis (HP:0007502)2.81012062
31Nasal polyposis (HP:0100582)2.80898875
32Spinal rigidity (HP:0003306)2.80718913
33Vascular calcification (HP:0004934)2.80318974
34Abnormality of the nasal mucosa (HP:0000433)2.79665100
35Myocardial infarction (HP:0001658)2.78246982
36Diaphragmatic weakness (HP:0009113)2.77070348
37Prolonged partial thromboplastin time (HP:0003645)2.76926581
38Cholelithiasis (HP:0001081)2.72403120
39Abnormal respiratory motile cilium physiology (HP:0012261)2.71901021
40Mitral stenosis (HP:0001718)2.71534572
41Acanthocytosis (HP:0001927)2.66699111
42Abnormal respiratory epithelium morphology (HP:0012253)2.65861270
43Abnormal respiratory motile cilium morphology (HP:0005938)2.65861270
44Cerebral aneurysm (HP:0004944)2.63795947
45Generalized amyotrophy (HP:0003700)2.62204706
46Nuclear cataract (HP:0100018)2.59900623
47Abnormality of reticulocytes (HP:0004312)2.59337524
48Rhinitis (HP:0012384)2.58366372
49Aortic dissection (HP:0002647)2.55314529
50Intrahepatic cholestasis (HP:0001406)2.54854794
51Xanthomatosis (HP:0000991)2.53862637
52Hyperbilirubinemia (HP:0002904)2.52789018
53Shallow orbits (HP:0000586)2.51972430
54Fragile skin (HP:0001030)2.51291185
55Abnormal ciliary motility (HP:0012262)2.51196906
56Abnormality of cells of the erythroid lineage (HP:0012130)2.50385860
57Abnormality of the distal phalanges of the toes (HP:0010182)2.50288745
58Muscle fiber splitting (HP:0003555)2.49909666
59Distal upper limb amyotrophy (HP:0007149)2.49019382
60Upper limb amyotrophy (HP:0009129)2.49019382
61Peritonitis (HP:0002586)2.38977201
62Dynein arm defect of respiratory motile cilia (HP:0012255)2.37255899
63Absent/shortened dynein arms (HP:0200106)2.37255899
64Joint hemorrhage (HP:0005261)2.35970221
65Abnormality of the acetabulum (HP:0003170)2.34807542
66Nephritis (HP:0000123)2.34200039
67Hypoalphalipoproteinemia (HP:0003233)2.34049885
68Abnormal gallbladder morphology (HP:0012437)2.32334211
69Exercise-induced muscle cramps (HP:0003710)2.29843779
70Deep venous thrombosis (HP:0002625)2.29195712
71Lipoatrophy (HP:0100578)2.28422713
72Asymmetric septal hypertrophy (HP:0001670)2.26284587
73Ileus (HP:0002595)2.25716825
74Arterial tortuosity (HP:0005116)2.25604069
75Rhabdomyolysis (HP:0003201)2.25220227
76Increased variability in muscle fiber diameter (HP:0003557)2.23056381
77Difficulty climbing stairs (HP:0003551)2.21835678
78Urinary glycosaminoglycan excretion (HP:0003541)2.20355264
79Mucopolysacchariduria (HP:0008155)2.20355264
80Wrist flexion contracture (HP:0001239)2.19761186
81Complement deficiency (HP:0004431)2.19443007
82Abnormality of the intrinsic pathway (HP:0010989)2.19293454
83* Increased serum ferritin (HP:0003281)2.19093888
84Vascular tortuosity (HP:0004948)2.16058379
85Genu recurvatum (HP:0002816)2.15960618
86Abnormality of the common coagulation pathway (HP:0010990)2.14760137
87Mildly elevated creatine phosphokinase (HP:0008180)2.13040474
88Hypobetalipoproteinemia (HP:0003563)2.12688038
89Dysostosis multiplex (HP:0000943)2.12005299
90Hyperlipoproteinemia (HP:0010980)2.11951532
91Abnormal delivery (HP:0001787)2.11935824
92Petechiae (HP:0000967)2.11680909
93Distal lower limb amyotrophy (HP:0008944)2.10943085
94Abnormality of polysaccharide metabolism (HP:0011012)2.10888672
95Abnormality of glycosaminoglycan metabolism (HP:0004371)2.10888672
96Abnormality of mucopolysaccharide metabolism (HP:0011020)2.10888672
97Flat acetabular roof (HP:0003180)2.10336623
98Abnormality of skeletal muscle fiber size (HP:0012084)2.08794014
99Hand muscle atrophy (HP:0009130)2.07104698
100Amyloidosis (HP:0011034)2.07101401
101Osteolytic defects of the hand bones (HP:0009699)2.06578358
102Osteolytic defects of the phalanges of the hand (HP:0009771)2.06578358
103Abnormality of the Achilles tendon (HP:0005109)2.05891182
104Achilles tendon contracture (HP:0001771)2.04870128
105Back pain (HP:0003418)2.04634547
106Blue sclerae (HP:0000592)2.04265954
107Hyperammonemia (HP:0001987)2.03851413
108Chronic bronchitis (HP:0004469)2.03800153
109Abnormality of fatty-acid metabolism (HP:0004359)2.03496649
110Mesangial abnormality (HP:0001966)2.03222466
111Abnormal cartilage morphology (HP:0002763)2.03013519
112Myoglobinuria (HP:0002913)2.02150221
113Bladder diverticulum (HP:0000015)2.01965503
114Natal tooth (HP:0000695)2.01495520
115Dilatation of the ascending aorta (HP:0005111)2.01367873
116Ulnar bowing (HP:0003031)2.00676195
117Abnormality of complement system (HP:0005339)1.99316823
118Slender long bone (HP:0003100)1.99292094
119Hyperacusis (HP:0010780)1.97992654
120Ventricular tachycardia (HP:0004756)1.97431881
121Hemorrhage of the eye (HP:0011885)1.97046083
122Elbow flexion contracture (HP:0002987)1.96181334
123Multiple enchondromatosis (HP:0005701)1.95571904
124* Abnormality of iron homeostasis (HP:0011031)1.93432946
125Abnormality of dentin (HP:0010299)1.92921493
126Breech presentation (HP:0001623)1.92779947
127Wormian bones (HP:0002645)1.91867539
128Hypertriglyceridemia (HP:0002155)1.91737442
129J-shaped sella turcica (HP:0002680)1.91219981
130Global brain atrophy (HP:0002283)1.90355673
131Aortic aneurysm (HP:0004942)1.90293344
132Increased cerebral lipofuscin (HP:0011813)1.89868605
133Recurrent gram-negative bacterial infections (HP:0005420)1.87828411
134Abnormality of carpal bone ossification (HP:0006257)1.87757748
135Abnormal gallbladder physiology (HP:0012438)1.87742528
136Cholecystitis (HP:0001082)1.87742528
137Neoplasm of head and neck (HP:0012288)1.84883645
138Esophageal neoplasm (HP:0100751)1.84883645
139Hypercholesterolemia (HP:0003124)1.83350631
140Systemic lupus erythematosus (HP:0002725)1.83132253
141Hepatocellular carcinoma (HP:0001402)1.82569442
142Hyperglycinuria (HP:0003108)1.82473600
143Absent frontal sinuses (HP:0002688)1.82361453
144Interstitial pulmonary disease (HP:0006530)1.81132565
145* Abnormality of transition element cation homeostasis (HP:0011030)1.80242224
146Neurofibrillary tangles (HP:0002185)1.80220915
147Joint stiffness (HP:0001387)1.79983104
148Beaking of vertebral bodies (HP:0004568)1.79676924
149Atrophic scars (HP:0001075)1.78802189
150Hypoglycemic coma (HP:0001325)1.78458613
151Centrally nucleated skeletal muscle fibers (HP:0003687)1.77836883
152Male infertility (HP:0003251)1.77311690
153Axonal loss (HP:0003447)1.75341927
154Purpura (HP:0000979)1.74634389
155Mitral valve prolapse (HP:0001634)1.74595572
156Prolonged bleeding time (HP:0003010)1.73655665
157Neonatal short-limb short stature (HP:0008921)1.73389173
158Hypolipoproteinemia (HP:0010981)1.71377317
159Alopecia of scalp (HP:0002293)1.69789022
160Selective tooth agenesis (HP:0001592)1.69258411
161Abnormality of dicarboxylic acid metabolism (HP:0010995)1.68509283
162Dicarboxylic aciduria (HP:0003215)1.68509283
163Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.66919143
164Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.64989695
165Skin nodule (HP:0200036)1.64947750

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.29509295
2NME23.73602251
3PKN23.12414049
4TTN3.10924083
5ERN12.69516224
6EIF2AK12.63316793
7EEF2K2.54582939
8SMG12.44239077
9SIK12.40769032
10BCKDK2.40233442
11BUB12.35904702
12TESK12.29902958
13ICK2.29766117
14NEK12.02893594
15PIM21.99736689
16SCYL21.76869238
17MAPK151.74197988
18WEE11.71293525
19LIMK11.71198916
20KDR1.68818867
21PTK21.68307624
22PRPF4B1.66770000
23ARAF1.65090555
24DDR21.62730485
25MET1.60538485
26NEK21.54181735
27MOS1.50443084
28TGFBR21.49429090
29MAP3K101.42711321
30FLT31.42428170
31LRRK21.40261228
32MAP2K31.38382751
33TRPM71.32408492
34KIT1.32063913
35STK31.24801524
36PDGFRA1.23878970
37ERBB41.23009605
38MAPKAPK31.19818294
39RPS6KA41.19694125
40CAMK1D1.15267206
41ABL21.14887724
42STK41.13262832
43NEK91.11572179
44STK241.11527557
45NTRK11.08735556
46ZAK1.08157877
47PAK41.06844664
48MAPK111.06356471
49PDK31.06207150
50PDK41.06207150
51CDC71.06115599
52LMTK21.05277657
53TTK0.98495412
54CDK40.97553773
55DYRK30.96872828
56PAK20.96239836
57CDC42BPA0.94794097
58MAP3K110.94195525
59BMX0.93853973
60STK100.93342069
61MYLK0.93224883
62MAP3K130.92777302
63TYK20.92047618
64TBK10.91670789
65MAP3K80.90657744
66IRAK30.90003806
67PIM10.87545817
68PBK0.86760384
69BRSK20.86285746
70MAP3K30.85092136
71PTK60.83986033
72LATS20.83563888
73EPHB20.82924212
74CDK120.81846982
75CDK70.80117692
76RIPK10.78597048
77ILK0.77402169
78ZAP700.75448870
79BRSK10.72039868
80MAP3K60.71967409
81AURKB0.71307854
82MAP3K20.70278615
83RPS6KB20.70046011
84JAK20.68634241
85RPS6KA20.68508810
86PDPK10.66747732
87STK380.65849285
88MTOR0.65612081
89PLK10.64475294
90MAP3K140.63899793
91PRKD20.63483760
92MST1R0.61993898
93OBSCN0.61524590
94MAPK120.58431480
95CDK60.57025809
96MAP3K10.56913401
97PAK10.56627524
98BRAF0.56615072
99TLK10.54466984
100KSR20.52891586
101JAK30.52579017
102CAMK2G0.52302724
103PDK20.51338904
104PDGFRB0.51078167
105JAK10.51000339
106LATS10.50119327
107ROCK20.49934557
108FGFR40.49930588
109DAPK30.49025568
110MAPKAPK20.48618392
111AURKA0.48442651
112ATR0.47695643
113PRKG20.47367496
114PIK3CG0.46974422
115EIF2AK30.46960901
116TESK20.46297834
117STK160.45986127
118GSK3A0.45865810
119IKBKB0.44387035
120BLK0.44286035
121CSF1R0.43919064
122PHKG10.42414971
123PHKG20.42414971
124PRKAA20.41310937
125AKT20.41193989
126TIE10.40662977
127MAP4K10.40577960
128RPS6KA60.40047661
129GRK70.40006647
130EPHA20.39842788
131EPHB10.39378051
132MST40.39044800
133TAOK20.38600029
134RPS6KC10.37961032
135RPS6KL10.37961032
136ROCK10.36943965
137DMPK0.34324888
138MAP3K120.32600983
139CDK80.30771741
140CLK10.29889781
141TAOK10.29472268
142HIPK20.27507069
143MELK0.24848668
144NME10.23910694

Predicted pathways (KEGG)

RankGene SetZ-score
12-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.94745420
2Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.90090409
3Caffeine metabolism_Homo sapiens_hsa002322.79009281
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.78127764
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.52718758
6DNA replication_Homo sapiens_hsa030302.48462445
7Fatty acid degradation_Homo sapiens_hsa000712.25191389
8Tyrosine metabolism_Homo sapiens_hsa003502.18359190
9Retinol metabolism_Homo sapiens_hsa008302.05689486
10Prion diseases_Homo sapiens_hsa050201.95671549
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.94818082
12One carbon pool by folate_Homo sapiens_hsa006701.90129917
13Carbon metabolism_Homo sapiens_hsa012001.90063447
14Vitamin B6 metabolism_Homo sapiens_hsa007501.80203277
15Histidine metabolism_Homo sapiens_hsa003401.77928532
16Fatty acid metabolism_Homo sapiens_hsa012121.76879629
17Propanoate metabolism_Homo sapiens_hsa006401.73660367
18PPAR signaling pathway_Homo sapiens_hsa033201.72169827
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.70637212
20Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.69161741
21Pentose phosphate pathway_Homo sapiens_hsa000301.68133196
22Biosynthesis of amino acids_Homo sapiens_hsa012301.61623403
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.61263486
24Sulfur relay system_Homo sapiens_hsa041221.59140685
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.55178351
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.54850602
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.50375358
28Complement and coagulation cascades_Homo sapiens_hsa046101.45644159
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.40715402
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.37956751
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36658196
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.35555949
33ECM-receptor interaction_Homo sapiens_hsa045121.34020557
34Fatty acid biosynthesis_Homo sapiens_hsa000611.31645535
35Ribosome_Homo sapiens_hsa030101.30886349
36Proteasome_Homo sapiens_hsa030501.29942964
37Selenocompound metabolism_Homo sapiens_hsa004501.29821020
38Folate biosynthesis_Homo sapiens_hsa007901.28340274
39Pyruvate metabolism_Homo sapiens_hsa006201.25869944
40Staphylococcus aureus infection_Homo sapiens_hsa051501.23244848
41Glycosaminoglycan degradation_Homo sapiens_hsa005311.22049767
42Arginine biosynthesis_Homo sapiens_hsa002201.21558073
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.21058213
44Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.18159490
45Galactose metabolism_Homo sapiens_hsa000521.15822588
46Mismatch repair_Homo sapiens_hsa034301.15142749
47Starch and sucrose metabolism_Homo sapiens_hsa005001.14960257
48beta-Alanine metabolism_Homo sapiens_hsa004101.12581205
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.10087347
50Peroxisome_Homo sapiens_hsa041461.09926449
51Nitrogen metabolism_Homo sapiens_hsa009101.07918108
52Pyrimidine metabolism_Homo sapiens_hsa002401.07651001
53Base excision repair_Homo sapiens_hsa034101.06323233
54Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.04798753
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.03393577
56Malaria_Homo sapiens_hsa051441.01731313
57Lysosome_Homo sapiens_hsa041421.01692963
58Tryptophan metabolism_Homo sapiens_hsa003801.00917621
59Cell cycle_Homo sapiens_hsa041100.99289872
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.96547970
61Pertussis_Homo sapiens_hsa051330.95635118
62Adipocytokine signaling pathway_Homo sapiens_hsa049200.88891018
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.86868256
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84048805
65Glutathione metabolism_Homo sapiens_hsa004800.82873765
66Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.79548636
67Other glycan degradation_Homo sapiens_hsa005110.78938205
68Small cell lung cancer_Homo sapiens_hsa052220.78868267
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.76504505
70Bladder cancer_Homo sapiens_hsa052190.76364994
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.74912495
72Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.73766885
73ABC transporters_Homo sapiens_hsa020100.73506591
74Proteoglycans in cancer_Homo sapiens_hsa052050.73099709
75Nucleotide excision repair_Homo sapiens_hsa034200.72796289
76Arginine and proline metabolism_Homo sapiens_hsa003300.71059754
77Sulfur metabolism_Homo sapiens_hsa009200.69692293
78RNA transport_Homo sapiens_hsa030130.68599609
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.66989983
80Systemic lupus erythematosus_Homo sapiens_hsa053220.65607887
81* p53 signaling pathway_Homo sapiens_hsa041150.65168790
82Amoebiasis_Homo sapiens_hsa051460.65017630
83Lysine degradation_Homo sapiens_hsa003100.64487802
84Protein digestion and absorption_Homo sapiens_hsa049740.62981688
85Fat digestion and absorption_Homo sapiens_hsa049750.62522557
86Sphingolipid metabolism_Homo sapiens_hsa006000.61652251
87RNA polymerase_Homo sapiens_hsa030200.60927195
88Chronic myeloid leukemia_Homo sapiens_hsa052200.60690194
89Focal adhesion_Homo sapiens_hsa045100.59155551
90Mineral absorption_Homo sapiens_hsa049780.57894068
91Vitamin digestion and absorption_Homo sapiens_hsa049770.55748889
92Insulin resistance_Homo sapiens_hsa049310.55433520
93Homologous recombination_Homo sapiens_hsa034400.54678511
94Fructose and mannose metabolism_Homo sapiens_hsa000510.54540980
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54180240
96AMPK signaling pathway_Homo sapiens_hsa041520.53939620
97Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.53417106
98Vibrio cholerae infection_Homo sapiens_hsa051100.52714083
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.52456858
100Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51152245
101N-Glycan biosynthesis_Homo sapiens_hsa005100.50887669
102Renin-angiotensin system_Homo sapiens_hsa046140.50214455
103Arachidonic acid metabolism_Homo sapiens_hsa005900.49712814
104Pancreatic cancer_Homo sapiens_hsa052120.48484783
105Apoptosis_Homo sapiens_hsa042100.48325345
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48031888
107Legionellosis_Homo sapiens_hsa051340.47921145
108Spliceosome_Homo sapiens_hsa030400.47622057
109Phenylalanine metabolism_Homo sapiens_hsa003600.47241505
110Metabolic pathways_Homo sapiens_hsa011000.47218412
111TNF signaling pathway_Homo sapiens_hsa046680.46976345
112Salmonella infection_Homo sapiens_hsa051320.46668936
113Adherens junction_Homo sapiens_hsa045200.44845096
114AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44646553
115Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.44145046
116Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.43972922
117Viral carcinogenesis_Homo sapiens_hsa052030.41397895
118Chemical carcinogenesis_Homo sapiens_hsa052040.40924072
119Hepatitis C_Homo sapiens_hsa051600.40420769
120Antigen processing and presentation_Homo sapiens_hsa046120.39367194
121Bile secretion_Homo sapiens_hsa049760.38175806
122Purine metabolism_Homo sapiens_hsa002300.37467885
123Thyroid cancer_Homo sapiens_hsa052160.36010306
124Acute myeloid leukemia_Homo sapiens_hsa052210.35821272
125Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35506886
126Insulin signaling pathway_Homo sapiens_hsa049100.35271500
127Toll-like receptor signaling pathway_Homo sapiens_hsa046200.33873008
128Leukocyte transendothelial migration_Homo sapiens_hsa046700.32127010
129Phagosome_Homo sapiens_hsa041450.31339161
130Notch signaling pathway_Homo sapiens_hsa043300.30536876
131Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30443919
132Shigellosis_Homo sapiens_hsa051310.29036239
133Dilated cardiomyopathy_Homo sapiens_hsa054140.26846161
134Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.25803960

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »