STEAP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1biotin metabolic process (GO:0006768)7.18740830
2branching involved in prostate gland morphogenesis (GO:0060442)6.13151522
3prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060525.65878616
4cellular response to vitamin D (GO:0071305)4.92496026
5negative regulation of glycogen biosynthetic process (GO:0045719)4.90382009
6metanephric mesenchyme development (GO:0072075)4.67674579
7chondrocyte proliferation (GO:0035988)4.67428107
8cellular response to vitamin (GO:0071295)4.47733865
9negative regulation of glycogen metabolic process (GO:0070874)4.45061058
10branched-chain amino acid catabolic process (GO:0009083)4.40978440
11kidney mesenchyme development (GO:0072074)4.28870468
12carnitine shuttle (GO:0006853)4.17580423
13artery development (GO:0060840)4.12922171
14epithelial cell maturation (GO:0002070)4.10537177
15adaptation of signaling pathway (GO:0023058)3.92249721
16auditory receptor cell differentiation (GO:0042491)3.90576144
17regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.84375317
18cerebellar Purkinje cell layer development (GO:0021680)3.82644715
19intestinal epithelial cell development (GO:0060576)3.79727889
20collagen fibril organization (GO:0030199)3.77881417
21fatty acid transmembrane transport (GO:1902001)3.74295386
22metanephric nephron epithelium development (GO:0072243)3.72143867
23metanephric tubule development (GO:0072170)3.57079696
24metanephric nephron tubule development (GO:0072234)3.57079696
25zinc ion transmembrane transport (GO:0071577)3.51320302
26mitotic cell cycle arrest (GO:0071850)3.51149133
27cellular ketone body metabolic process (GO:0046950)3.45838242
28positive regulation of glycolytic process (GO:0045821)3.43986282
29zinc ion homeostasis (GO:0055069)3.42902981
30hippo signaling (GO:0035329)3.41188072
31cell adhesion mediated by integrin (GO:0033627)3.40815099
32branched-chain amino acid metabolic process (GO:0009081)3.40254013
33mesenchymal-epithelial cell signaling (GO:0060638)3.40041377
34carnitine transmembrane transport (GO:1902603)3.39438138
35metanephric epithelium development (GO:0072207)3.36648130
36prostate gland epithelium morphogenesis (GO:0060740)3.34680060
37regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.27664704
38beta-amyloid metabolic process (GO:0050435)3.25483891
39positive regulation of histone deacetylation (GO:0031065)3.24198238
40collecting duct development (GO:0072044)3.22529169
41amino-acid betaine transport (GO:0015838)3.20313779
42carnitine transport (GO:0015879)3.20313779
43mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.19556989
44replicative senescence (GO:0090399)3.18638168
45coenzyme A metabolic process (GO:0015936)3.17318461
46sequestering of extracellular ligand from receptor (GO:0035581)3.15329403
47fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.12738605
48regulation of receptor binding (GO:1900120)3.10883689
49endocrine hormone secretion (GO:0060986)3.10294317
50regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.09203242
51positive regulation of steroid hormone secretion (GO:2000833)3.08784587
52anterior/posterior axis specification, embryo (GO:0008595)3.08620823
53mesodermal cell differentiation (GO:0048333)3.03423359
54polyol catabolic process (GO:0046174)3.03077723
55water-soluble vitamin biosynthetic process (GO:0042364)3.03008849
56positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.01597737
57long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.01485557
58ketone body metabolic process (GO:1902224)3.00803637
59quaternary ammonium group transport (GO:0015697)3.00267659
60protein localization to cell surface (GO:0034394)2.96864316
61regulation of hippo signaling (GO:0035330)2.95694649
62negative regulation of fatty acid transport (GO:2000192)2.94797712
63negative regulation of glucose import (GO:0046325)2.94148308
64axon extension involved in axon guidance (GO:0048846)2.93607923
65neuron projection extension involved in neuron projection guidance (GO:1902284)2.93607923
66membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.90929757
67retinal metabolic process (GO:0042574)2.90511433
68branching involved in salivary gland morphogenesis (GO:0060445)2.88278983
69L-serine metabolic process (GO:0006563)2.87098770
70regulation of apoptotic process involved in morphogenesis (GO:1902337)2.87050239
71negative regulation of JUN kinase activity (GO:0043508)2.85490850
72protein localization to synapse (GO:0035418)2.83377077
73protein import into peroxisome matrix (GO:0016558)2.81240067
74UDP-N-acetylglucosamine metabolic process (GO:0006047)2.81138247
75fatty-acyl-CoA biosynthetic process (GO:0046949)2.80181111
76zinc ion transport (GO:0006829)2.78407883
77positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.78049290
78positive regulation of endothelial cell apoptotic process (GO:2000353)2.77718237
79phenol-containing compound catabolic process (GO:0019336)2.75520940
80lung lobe morphogenesis (GO:0060463)2.75369705
81positive regulation of macroautophagy (GO:0016239)2.75223795
82nephron tubule development (GO:0072080)2.75075440
83pteridine-containing compound metabolic process (GO:0042558)2.73234478
84regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.72976281
85folic acid-containing compound metabolic process (GO:0006760)2.71027075
86positive regulation of actin filament depolymerization (GO:0030836)2.70740251
87muscle cell migration (GO:0014812)2.70043412
88inositol phosphate-mediated signaling (GO:0048016)2.68786153
89response to pheromone (GO:0019236)2.68263060
90paraxial mesoderm development (GO:0048339)2.67713632
91regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.66648309
92protein autoprocessing (GO:0016540)2.65129535
93plasma membrane repair (GO:0001778)2.64460962
94positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.64030698
95renal filtration (GO:0097205)2.62807500
96nephron epithelium development (GO:0072009)2.62439459
97nephron tubule formation (GO:0072079)2.61663093
98positive regulation of macrophage activation (GO:0043032)2.61568877
99astrocyte differentiation (GO:0048708)2.61462649
100somite rostral/caudal axis specification (GO:0032525)2.61439438
101nephron tubule morphogenesis (GO:0072078)2.61427982
102nephron epithelium morphogenesis (GO:0072088)2.61427982
103craniofacial suture morphogenesis (GO:0097094)2.61080597
104negative regulation of chondrocyte differentiation (GO:0032331)2.59978710
105anatomical structure arrangement (GO:0048532)2.59615184
106response to testosterone (GO:0033574)2.59253514
107positive regulation of protein localization to plasma membrane (GO:1903078)2.58140938
108righting reflex (GO:0060013)2.57456526
109bone remodeling (GO:0046849)2.56988989
110regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.56670878
111membrane repolarization during action potential (GO:0086011)2.55367037
112regulation of glucan biosynthetic process (GO:0010962)2.53845315
113regulation of glycogen biosynthetic process (GO:0005979)2.53845315
114positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.52783226
115regulation of chemokine secretion (GO:0090196)2.52572500
116ER overload response (GO:0006983)2.52150069
117chondrocyte development (GO:0002063)2.52076506
118positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.51297310
119ribonucleoside bisphosphate metabolic process (GO:0033875)2.50976433
120nucleoside bisphosphate metabolic process (GO:0033865)2.50976433
121purine nucleoside bisphosphate metabolic process (GO:0034032)2.50976433
122cell migration involved in sprouting angiogenesis (GO:0002042)2.50956921
123tight junction assembly (GO:0070830)2.50814062
124hemidesmosome assembly (GO:0031581)2.50788866
125toxin transport (GO:1901998)2.50187252
126insulin-like growth factor receptor signaling pathway (GO:0048009)2.50100139
127embryonic body morphogenesis (GO:0010172)2.49933271
128positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.48635363
129regulation of morphogenesis of a branching structure (GO:0060688)2.48446372
130COPII vesicle coating (GO:0048208)2.47930546
131retinol metabolic process (GO:0042572)2.47014600
132endodermal cell differentiation (GO:0035987)2.46646056
133ovulation from ovarian follicle (GO:0001542)2.46243307
134regulation of endothelial cell chemotaxis (GO:2001026)2.45555596
135dorsal/ventral neural tube patterning (GO:0021904)2.45431959
136acetyl-CoA metabolic process (GO:0006084)2.44617921
137endothelial cell chemotaxis (GO:0035767)2.44346549
138renal tubule morphogenesis (GO:0061333)2.44315316
139positive regulation of membrane potential (GO:0045838)2.44296991
140positive regulation of hormone biosynthetic process (GO:0046886)2.43470658
141Golgi transport vesicle coating (GO:0048200)2.43202763
142COPI coating of Golgi vesicle (GO:0048205)2.43202763
143skin morphogenesis (GO:0043589)2.42786756
144lymphangiogenesis (GO:0001946)2.42236874
145regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)2.42140995
146regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.41478437
147toxin metabolic process (GO:0009404)2.40880206
148neurotransmitter catabolic process (GO:0042135)2.40791609
149synaptic vesicle docking involved in exocytosis (GO:0016081)2.40099901
150lens fiber cell development (GO:0070307)2.39942774
151cranial nerve morphogenesis (GO:0021602)2.39154906
152bone trabecula formation (GO:0060346)2.39085084
153ganglion development (GO:0061548)2.38685347
154negative regulation of systemic arterial blood pressure (GO:0003085)2.38193676
155vascular endothelial growth factor signaling pathway (GO:0038084)2.38004023
156renal tubule development (GO:0061326)2.37998291
157pattern specification involved in kidney development (GO:0061004)2.37788353
158embryonic cranial skeleton morphogenesis (GO:0048701)2.37775489
159positive regulation of catenin import into nucleus (GO:0035413)2.37566622
160regulation of integrin-mediated signaling pathway (GO:2001044)2.36791010
161multicellular organismal movement (GO:0050879)2.36665677
162musculoskeletal movement (GO:0050881)2.36665677
163cell differentiation involved in metanephros development (GO:0072202)2.35999002
164negative regulation of keratinocyte proliferation (GO:0010839)2.35683304
165embryonic axis specification (GO:0000578)2.35303235
166regulation of clathrin-mediated endocytosis (GO:2000369)2.35076304
167response to nitrosative stress (GO:0051409)2.34533744
168magnesium ion transport (GO:0015693)2.34484117
169glutamate secretion (GO:0014047)2.34031234
170acyl-CoA biosynthetic process (GO:0071616)2.33874524
171thioester biosynthetic process (GO:0035384)2.33874524
172protein heterotrimerization (GO:0070208)2.33432956
173glandular epithelial cell differentiation (GO:0002067)2.32890464
174Golgi to endosome transport (GO:0006895)2.32695886
175neural crest cell development (GO:0014032)2.32625905
176negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.32439458
177bicarbonate transport (GO:0015701)2.31605936
178apical protein localization (GO:0045176)2.31512316
179kidney morphogenesis (GO:0060993)2.31300718
180regulation of axon extension involved in axon guidance (GO:0048841)2.31048038
181regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.29440463
182myoblast migration (GO:0051451)2.29420230
183wound healing, spreading of epidermal cells (GO:0035313)2.29335642
184activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.26770724
185cerebellar granule cell differentiation (GO:0021707)2.25979075
186positive regulation of mesenchymal cell proliferation (GO:0002053)2.24816337
187substrate-dependent cell migration (GO:0006929)2.24339365
188cell-cell junction assembly (GO:0007043)2.21396562
189branch elongation of an epithelium (GO:0060602)2.21150518
190extracellular negative regulation of signal transduction (GO:1900116)2.20817954
191extracellular regulation of signal transduction (GO:1900115)2.20817954
192cytoskeletal anchoring at plasma membrane (GO:0007016)2.20650400
193negative regulation of axon extension involved in axon guidance (GO:0048843)2.20039749
194semaphorin-plexin signaling pathway (GO:0071526)2.19656239
195response to vitamin D (GO:0033280)2.19018945
196negative regulation of hormone metabolic process (GO:0032351)2.19006329
197negative regulation of hormone biosynthetic process (GO:0032353)2.19006329
198camera-type eye morphogenesis (GO:0048593)2.17287767

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1AR_21909140_ChIP-Seq_LNCAP_Human4.33432752
2IGF1R_20145208_ChIP-Seq_DFB_Human3.32619978
3VDR_22108803_ChIP-Seq_LS180_Human3.20637375
4AR_21915096_ChIP-Seq_LNCaP-1F5_Human3.19428174
5TRIM28_21343339_ChIP-Seq_HEK293_Human3.19220664
6FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human3.02010299
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.87916750
8GBX2_23144817_ChIP-Seq_PC3_Human2.68036621
9NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.56219146
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.39395305
11* CHD1_26751641_Chip-Seq_LNCaP_Human2.29040173
12ZNF217_24962896_ChIP-Seq_MCF-7_Human2.26741649
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.19570847
14* FOXA1_25552417_ChIP-Seq_VCAP_Human2.13246824
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.09339024
16SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.06738915
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.00093689
18CJUN_26792858_Chip-Seq_BT549_Human1.97055643
19ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.96685745
20EP300_21415370_ChIP-Seq_HL-1_Mouse1.94956312
21* CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.94562188
22NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.92579015
23NRF2_20460467_ChIP-Seq_MEFs_Mouse1.92579015
24ESR1_21235772_ChIP-Seq_MCF-7_Human1.91835589
25PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.90021491
26TP53_16413492_ChIP-PET_HCT116_Human1.87234863
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.85750696
28TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.85299036
29HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.85165641
30* PIAS1_25552417_ChIP-Seq_VCAP_Human1.85077951
31* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.75916138
32TAF15_26573619_Chip-Seq_HEK293_Human1.75734790
33SALL1_21062744_ChIP-ChIP_HESCs_Human1.75287092
34RBPJ_22232070_ChIP-Seq_NCS_Mouse1.74133487
35CDX2_19796622_ChIP-Seq_MESCs_Mouse1.72487551
36SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.72476966
37TP53_18474530_ChIP-ChIP_U2OS_Human1.71835680
38SMAD_19615063_ChIP-ChIP_OVARY_Human1.70679011
39WT1_19549856_ChIP-ChIP_CCG9911_Human1.70147714
40FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.68192853
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.61184841
42AR_25329375_ChIP-Seq_VCAP_Human1.59310000
43* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.59148192
44AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.58509007
45RNF2_18974828_ChIP-Seq_MESCs_Mouse1.51197334
46EZH2_18974828_ChIP-Seq_MESCs_Mouse1.51197334
47* BRD4_25478319_ChIP-Seq_HGPS_Human1.50454030
48ESR1_20079471_ChIP-ChIP_T-47D_Human1.47410223
49SMAD4_21799915_ChIP-Seq_A2780_Human1.45146143
50PPAR_26484153_Chip-Seq_NCI-H1993_Human1.41823038
51* ZNF274_21170338_ChIP-Seq_K562_Hela1.41800576
52SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.40457707
53AHR_22903824_ChIP-Seq_MCF-7_Human1.39907110
54HTT_18923047_ChIP-ChIP_STHdh_Human1.39431728
55SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.38716912
56SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.38303931
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.37085253
58EWS_26573619_Chip-Seq_HEK293_Human1.36822201
59NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.35797828
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35791069
61ESR2_21235772_ChIP-Seq_MCF-7_Human1.34786258
62ARNT_22903824_ChIP-Seq_MCF-7_Human1.33676058
63FLI1_27457419_Chip-Seq_LIVER_Mouse1.33142309
64TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32865648
65SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.32360075
66CTNNB1_20460455_ChIP-Seq_HCT116_Human1.31386465
67OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30359962
68CLOCK_20551151_ChIP-Seq_293T_Human1.29406670
69WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.29073495
70SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27558131
71FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26047491
72AR_21572438_ChIP-Seq_LNCaP_Human1.25590952
73SOX9_24532713_ChIP-Seq_HFSC_Mouse1.25576763
74MTF2_20144788_ChIP-Seq_MESCs_Mouse1.24846819
75GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24411762
76TCF4_23295773_ChIP-Seq_U87_Human1.23793988
77NR3C1_21868756_ChIP-Seq_MCF10A_Human1.23084080
78RXR_22108803_ChIP-Seq_LS180_Human1.22643387
79EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.22438701
80ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.22438475
81RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21759095
82STAT3_23295773_ChIP-Seq_U87_Human1.21703602
83SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.20671304
84SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.20671304
85TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.20294956
86TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19861819
87* SOX2_20726797_ChIP-Seq_SW620_Human1.19795604
88JARID2_20064375_ChIP-Seq_MESCs_Mouse1.19119761
89JARID2_20075857_ChIP-Seq_MESCs_Mouse1.17108373
90CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16112167
91ISL1_27105846_Chip-Seq_CPCs_Mouse1.15506447
92DROSHA_22980978_ChIP-Seq_HELA_Human1.15472325
93ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14339885
94FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13442896
95CBX2_27304074_Chip-Seq_ESCs_Mouse1.13302846
96SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13253781
97CTBP1_25329375_ChIP-Seq_LNCAP_Human1.12699822
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12699711
99SALL4_18804426_ChIP-ChIP_XEN_Mouse1.12404957
100PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12101039
101TP63_23658742_ChIP-Seq_EP156T_Human1.11778567
102BCAT_22108803_ChIP-Seq_LS180_Human1.11057345
103TCF4_22108803_ChIP-Seq_LS180_Human1.11017167
104LXR_22158963_ChIP-Seq_LIVER_Mouse1.10741228
105CDX2_22108803_ChIP-Seq_LS180_Human1.10731377
106RUNX2_22187159_ChIP-Seq_PCA_Human1.10172371
107P300_19829295_ChIP-Seq_ESCs_Human1.10016963
108SMAD3_21741376_ChIP-Seq_HESCs_Human1.09828916
109WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09223031
110BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.08837899
111* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.07930526
112RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.07786922
113FOXO3_23340844_ChIP-Seq_DLD1_Human1.07186389
114TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07166217
115* ER_23166858_ChIP-Seq_MCF-7_Human1.06973585
116SMAD3_21741376_ChIP-Seq_EPCs_Human1.05781445
117SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.05388826
118RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05225981
119EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.05215510
120* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04251504
121SMAD4_21741376_ChIP-Seq_HESCs_Human1.04161983
122TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03959394
123YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03861616
124SOX2_27498859_Chip-Seq_STOMACH_Mouse1.03537315
125TCF4_18268006_ChIP-ChIP_LS174T_Human1.03441932
126AR_19668381_ChIP-Seq_PC3_Human1.03051999
127CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01391266
128PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.01123801
129MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00437636
130NR3C1_23031785_ChIP-Seq_PC12_Mouse1.00354966
131MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00052566
132FUS_26573619_Chip-Seq_HEK293_Human0.99033704
133EZH2_27304074_Chip-Seq_ESCs_Mouse0.98636494
134STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.97982787
135SOX2_21211035_ChIP-Seq_LN229_Gbm0.97113956
136FOXA2_19822575_ChIP-Seq_HepG2_Human0.96516977
137GATA4_25053715_ChIP-Seq_YYC3_Human0.93909359
138CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92104650
139GATA3_24758297_ChIP-Seq_MCF-7_Human0.91801587
140FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.91536420
141OCT1_27270436_Chip-Seq_PROSTATE_Human0.91342600
142ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.90396524
143BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88668879
144GATA6_25053715_ChIP-Seq_YYC3_Human0.88421011
145TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87282577
146STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.86435890
147AR_20517297_ChIP-Seq_VCAP_Human0.84750205

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004858_abnormal_nervous_system4.75800694
2MP0008438_abnormal_cutaneous_collagen4.24769713
3MP0002009_preneoplasia3.63884299
4MP0003011_delayed_dark_adaptation3.60291180
5MP0003123_paternal_imprinting3.32541272
6MP0005503_abnormal_tendon_morphology3.15277351
7MP0002166_altered_tumor_susceptibility3.08495669
8MP0005623_abnormal_meninges_morphology3.05843813
9MP0009384_cardiac_valve_regurgitation2.72708744
10MP0003705_abnormal_hypodermis_morpholog2.63087709
11MP0002877_abnormal_melanocyte_morpholog2.52533010
12MP0005275_abnormal_skin_tensile2.50966213
13MP0001958_emphysema2.49304380
14MP0010030_abnormal_orbit_morphology2.40558097
15MP0001299_abnormal_eye_distance/2.36512567
16MP0005310_abnormal_salivary_gland2.35561211
17MP0005647_abnormal_sex_gland2.31377968
18MP0003300_gastrointestinal_ulcer2.30257713
19MP0004272_abnormal_basement_membrane2.24806849
20MP0002006_tumorigenesis2.24409303
21MP0005257_abnormal_intraocular_pressure2.19770587
22MP0002876_abnormal_thyroid_physiology2.18370748
23MP0003279_aneurysm2.02882171
24MP0000537_abnormal_urethra_morphology1.94273810
25MP0002822_catalepsy1.94244322
26MP0005646_abnormal_pituitary_gland1.92481381
27MP0002896_abnormal_bone_mineralization1.91454730
28MP0003283_abnormal_digestive_organ1.90126360
29MP0002928_abnormal_bile_duct1.86047535
30MP0004145_abnormal_muscle_electrophysio1.78960903
31MP0003941_abnormal_skin_development1.78709985
32MP0002735_abnormal_chemical_nociception1.74412124
33MP0002736_abnormal_nociception_after1.73056829
34MP0000613_abnormal_salivary_gland1.72824859
35MP0005220_abnormal_exocrine_pancreas1.72520578
36MP0009250_abnormal_appendicular_skeleto1.71184223
37MP0002909_abnormal_adrenal_gland1.70559593
38MP0003315_abnormal_perineum_morphology1.69908609
39MP0005645_abnormal_hypothalamus_physiol1.69469387
40MP0003252_abnormal_bile_duct1.69320489
41MP0002168_other_aberrant_phenotype1.68736805
42MP0001501_abnormal_sleep_pattern1.67285796
43MP0002837_dystrophic_cardiac_calcinosis1.63701642
44MP0000013_abnormal_adipose_tissue1.62723873
45MP0000534_abnormal_ureter_morphology1.62527002
46MP0005508_abnormal_skeleton_morphology1.61944058
47MP0003942_abnormal_urinary_system1.61833251
48MP0005084_abnormal_gallbladder_morpholo1.57240474
49MP0003091_abnormal_cell_migration1.56944171
50MP0009053_abnormal_anal_canal1.54790688
51MP0001968_abnormal_touch/_nociception1.53732985
52MP0008004_abnormal_stomach_pH1.51482048
53MP0003385_abnormal_body_wall1.50916406
54MP0000462_abnormal_digestive_system1.50900024
55MP0001177_atelectasis1.48436947
56MP0004885_abnormal_endolymph1.46791355
57MP0003937_abnormal_limbs/digits/tail_de1.45648328
58MP0003879_abnormal_hair_cell1.43328490
59MP0000516_abnormal_urinary_system1.42834292
60MP0005367_renal/urinary_system_phenotyp1.42834292
61MP0002138_abnormal_hepatobiliary_system1.41748925
62MP0003566_abnormal_cell_adhesion1.38303709
63MP0008057_abnormal_DNA_replication1.37650750
64MP0005167_abnormal_blood-brain_barrier1.36942553
65MP0005636_abnormal_mineral_homeostasis1.35329085
66MP0004043_abnormal_pH_regulation1.33730714
67MP0003045_fibrosis1.32040014
68MP0003755_abnormal_palate_morphology1.31844849
69MP0005379_endocrine/exocrine_gland_phen1.30085778
70MP0001919_abnormal_reproductive_system1.29740742
71MP0002295_abnormal_pulmonary_circulatio1.28547053
72MP0002233_abnormal_nose_morphology1.28378578
73MP0000733_abnormal_muscle_development1.28132781
74MP0002060_abnormal_skin_morphology1.28110794
75MP0000428_abnormal_craniofacial_morphol1.25939259
76MP0009780_abnormal_chondrocyte_physiolo1.25460074
77MP0000566_synostosis1.23741071
78MP0004019_abnormal_vitamin_homeostasis1.23255416
79MP0000569_abnormal_digit_pigmentation1.22092355
80MP0001873_stomach_inflammation1.21945615
81MP0005670_abnormal_white_adipose1.21308319
82MP0003121_genomic_imprinting1.21209491
83MP0002108_abnormal_muscle_morphology1.20797066
84MP0003195_calcinosis1.20008266
85MP0002272_abnormal_nervous_system1.19848410
86MP0004270_analgesia1.19144385
87MP0002557_abnormal_social/conspecific_i1.18402560
88MP0010352_gastrointestinal_tract_polyps1.16127274
89MP0005023_abnormal_wound_healing1.16047456
90MP0000163_abnormal_cartilage_morphology1.15936254
91MP0003115_abnormal_respiratory_system1.14179033
92MP0004233_abnormal_muscle_weight1.13321104
93MP0002163_abnormal_gland_morphology1.12608575
94MP0001346_abnormal_lacrimal_gland1.10139084
95MP0005332_abnormal_amino_acid1.09468648
96MP0002177_abnormal_outer_ear1.07307491
97MP0002234_abnormal_pharynx_morphology1.06725078
98MP0006072_abnormal_retinal_apoptosis1.06457167
99MP0000678_abnormal_parathyroid_gland1.06293991
100MP0010234_abnormal_vibrissa_follicle1.06184746
101MP0005187_abnormal_penis_morphology1.06041659
102MP0000432_abnormal_head_morphology1.05877006
103MP0010386_abnormal_urinary_bladder1.04115799
104MP0010678_abnormal_skin_adnexa1.04038009
105MP0008961_abnormal_basal_metabolism1.03650956
106MP0002089_abnormal_postnatal_growth/wei1.03385930
107MP0002693_abnormal_pancreas_physiology1.03140759
108MP0001270_distended_abdomen1.03026207
109MP0000762_abnormal_tongue_morphology1.01285549
110MP0004924_abnormal_behavior1.01182172
111MP0005386_behavior/neurological_phenoty1.01182172
112MP0005248_abnormal_Harderian_gland1.01065801
113MP0002697_abnormal_eye_size1.01061871
114MP0002115_abnormal_skeleton_extremities1.00976773
115MP0001765_abnormal_ion_homeostasis0.99534952
116MP0005551_abnormal_eye_electrophysiolog0.99094319
117MP0002734_abnormal_mechanical_nocicepti0.98591919
118MP0000230_abnormal_systemic_arterial0.97142125
119MP0000627_abnormal_mammary_gland0.96973078
120MP0001944_abnormal_pancreas_morphology0.96935141
121MP0003633_abnormal_nervous_system0.96604297
122MP0002116_abnormal_craniofacial_bone0.96187345
123MP0003718_maternal_effect0.95985345
124MP0001486_abnormal_startle_reflex0.94728756
125MP0001324_abnormal_eye_pigmentation0.93330363
126MP0002063_abnormal_learning/memory/cond0.92698071
127MP0002078_abnormal_glucose_homeostasis0.92222115
128MP0009745_abnormal_behavioral_response0.91808261
129MP0003935_abnormal_craniofacial_develop0.91685957
130MP0005197_abnormal_uvea_morphology0.90865346
131MP0002064_seizures0.89480032
132MP0005085_abnormal_gallbladder_physiolo0.89232532
133MP0003936_abnormal_reproductive_system0.88670225
134MP0002160_abnormal_reproductive_system0.88544025
135MP0004085_abnormal_heartbeat0.87965357
136MP0002282_abnormal_trachea_morphology0.86802471
137MP0005395_other_phenotype0.86280908
138MP0002572_abnormal_emotion/affect_behav0.86166809
139MP0002092_abnormal_eye_morphology0.85575882
140MP0002067_abnormal_sensory_capabilities0.84576208
141MP0005171_absent_coat_pigmentation0.83517409
142MP0002932_abnormal_joint_morphology0.82420985
143MP0001286_abnormal_eye_development0.82397357
144MP0005253_abnormal_eye_physiology0.82341163
145MP0003890_abnormal_embryonic-extraembry0.82016466
146MP0005377_hearing/vestibular/ear_phenot0.81752835
147MP0003878_abnormal_ear_physiology0.81752835
148MP0002229_neurodegeneration0.81483439
149MP0008877_abnormal_DNA_methylation0.79602939
150MP0003953_abnormal_hormone_level0.78486266
151MP0004742_abnormal_vestibular_system0.78280479
152MP0002113_abnormal_skeleton_development0.78251171
153MP0002111_abnormal_tail_morphology0.78123894
154MP0001984_abnormal_olfaction0.77847936
155MP0000003_abnormal_adipose_tissue0.77642106
156MP0003635_abnormal_synaptic_transmissio0.77120976
157MP0005408_hypopigmentation0.76990281
158MP0001970_abnormal_pain_threshold0.76543481
159MP0002109_abnormal_limb_morphology0.76228855
160MP0000631_abnormal_neuroendocrine_gland0.76148865
161MP0000538_abnormal_urinary_bladder0.75241785
162MP0001485_abnormal_pinna_reflex0.74620402
163MP0000049_abnormal_middle_ear0.72624798
164MP0000383_abnormal_hair_follicle0.72160247
165MP0002249_abnormal_larynx_morphology0.71840813
166MP0001764_abnormal_homeostasis0.71431037
167MP0003950_abnormal_plasma_membrane0.71055274
168MP0004134_abnormal_chest_morphology0.69992076
169MP0001440_abnormal_grooming_behavior0.69576243
170MP0002090_abnormal_vision0.69312501
171MP0009046_muscle_twitch0.69127564
172MP0004133_heterotaxia0.69102712
173MP0005360_urolithiasis0.68815472
174MP0004036_abnormal_muscle_relaxation0.68612265
175MP0001664_abnormal_digestion0.68451860
176MP0001756_abnormal_urination0.67008675

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.15411755
2Abnormality of secondary sexual hair (HP:0009888)4.90728826
3Abnormality of the axillary hair (HP:0100134)4.90728826
4Sparse lateral eyebrow (HP:0005338)4.79874195
5Protrusio acetabuli (HP:0003179)4.68404088
6Ketoacidosis (HP:0001993)4.32450900
7Calf muscle hypertrophy (HP:0008981)3.98245104
8Dysmetric saccades (HP:0000641)3.89094237
9Testicular atrophy (HP:0000029)3.84271007
10Neonatal hypoglycemia (HP:0001998)3.78009182
11Azoospermia (HP:0000027)3.53280711
12Prostate neoplasm (HP:0100787)3.51579077
13Amelogenesis imperfecta (HP:0000705)3.50024793
14Gaze-evoked nystagmus (HP:0000640)3.46463511
15Hypothermia (HP:0002045)3.46181353
16Soft skin (HP:0000977)3.41659432
17Gonadotropin excess (HP:0000837)3.39639545
18Muscle hypertrophy of the lower extremities (HP:0008968)3.33966365
19Shallow orbits (HP:0000586)3.32996506
20Hyperglycinuria (HP:0003108)3.26979553
21Atrophic scars (HP:0001075)3.22436677
22Chorioretinal atrophy (HP:0000533)3.20183849
23Hypoglycemic coma (HP:0001325)3.11028456
24Abnormality of chloride homeostasis (HP:0011422)2.99397948
25Ketosis (HP:0001946)2.94812313
26Cervical subluxation (HP:0003308)2.93304244
27Aortic dissection (HP:0002647)2.90478342
28Lip pit (HP:0100267)2.90437818
29Depressed nasal tip (HP:0000437)2.87661957
30Fragile skin (HP:0001030)2.87459568
31Abnormality of glycine metabolism (HP:0010895)2.86970778
32Abnormality of serine family amino acid metabolism (HP:0010894)2.86970778
33Genetic anticipation (HP:0003743)2.85479150
34Obstructive sleep apnea (HP:0002870)2.84722976
35Short nail (HP:0001799)2.81716900
36Arterial tortuosity (HP:0005116)2.75413440
37Abnormality of dentin (HP:0010299)2.73435467
38Neonatal short-limb short stature (HP:0008921)2.73401225
39Vascular tortuosity (HP:0004948)2.70542978
40Abnormality of cochlea (HP:0000375)2.68865119
41Hyperactive renin-angiotensin system (HP:0000841)2.67449545
42Increased circulating renin level (HP:0000848)2.65301940
43Hyperinsulinemic hypoglycemia (HP:0000825)2.61902129
44Ankle contracture (HP:0006466)2.59750239
45Coronal craniosynostosis (HP:0004440)2.56213677
46Unilateral renal agenesis (HP:0000122)2.55079233
47Facial shape deformation (HP:0011334)2.49426113
48Potter facies (HP:0002009)2.49426113
49Focal segmental glomerulosclerosis (HP:0000097)2.48254801
50Intrahepatic cholestasis (HP:0001406)2.44505979
51Cerebral aneurysm (HP:0004944)2.44155519
52Aortic aneurysm (HP:0004942)2.41956572
53Progressive cerebellar ataxia (HP:0002073)2.41785658
54Rectal prolapse (HP:0002035)2.41165260
55Germ cell neoplasia (HP:0100728)2.40755657
56Hyperventilation (HP:0002883)2.39942847
57Neoplasm of the adrenal cortex (HP:0100641)2.38074962
58Advanced eruption of teeth (HP:0006288)2.33898060
59Abnormality of homocysteine metabolism (HP:0010919)2.32708830
60Homocystinuria (HP:0002156)2.32708830
61Dilatation of the ascending aorta (HP:0005111)2.32604841
62Hypokalemic alkalosis (HP:0001949)2.31993428
63Impaired smooth pursuit (HP:0007772)2.30440679
64Aplasia of the musculature (HP:0100854)2.26642551
65Testicular neoplasm (HP:0010788)2.26269308
66Follicular hyperkeratosis (HP:0007502)2.24705300
67Dysdiadochokinesis (HP:0002075)2.24653133
68Aplasia involving bones of the upper limbs (HP:0009823)2.24587963
69Aplasia of the phalanges of the hand (HP:0009802)2.24587963
70Aplasia involving bones of the extremities (HP:0009825)2.24587963
71Abnormal spermatogenesis (HP:0008669)2.24204229
72Peritonitis (HP:0002586)2.22122628
73Hypoplasia of the odontoid process (HP:0003311)2.21106467
74Tibial bowing (HP:0002982)2.19364562
75Large for gestational age (HP:0001520)2.18423493
76Metabolic alkalosis (HP:0200114)2.16551862
77Abnormality of macular pigmentation (HP:0008002)2.15324140
78Wormian bones (HP:0002645)2.15279303
79Mesomelia (HP:0003027)2.14846628
80Anal stenosis (HP:0002025)2.14651129
81Absent hair (HP:0002298)2.14636075
82Hamartoma of the eye (HP:0010568)2.14185893
83Femoral bowing (HP:0002980)2.14121723
84Macroorchidism (HP:0000053)2.12530433
85Bell-shaped thorax (HP:0001591)2.11841075
86Action tremor (HP:0002345)2.11031981
87Overgrowth (HP:0001548)2.10901648
88Abnormality of the nasal septum (HP:0000419)2.10559848
89Thin bony cortex (HP:0002753)2.09602162
90EEG with generalized epileptiform discharges (HP:0011198)2.09380751
91Hypoglycemic seizures (HP:0002173)2.08993331
92Bladder diverticulum (HP:0000015)2.08750484
93Polyuria (HP:0000103)2.07840398
94Limb ataxia (HP:0002070)2.07624670
95Epileptiform EEG discharges (HP:0011182)2.07206621
96Cardiovascular calcification (HP:0011915)2.07186132
97Broad metatarsal (HP:0001783)2.07037590
98Febrile seizures (HP:0002373)2.03871893
99Glomerulosclerosis (HP:0000096)2.02850947
100Wrist flexion contracture (HP:0001239)2.02457996
101Spinal rigidity (HP:0003306)2.02173859
102Spinal cord compression (HP:0002176)2.01519766
103Abnormality of the parathyroid morphology (HP:0011766)1.99343132
104Hypercalciuria (HP:0002150)1.98989596
105Down-sloping shoulders (HP:0200021)1.98188553
106Genu recurvatum (HP:0002816)1.98044632
107Abnormality of renal excretion (HP:0011036)1.97779449
108Impaired vibratory sensation (HP:0002495)1.97718834
109Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.97428819
110Short 1st metacarpal (HP:0010034)1.97428819
111Right ventricular cardiomyopathy (HP:0011663)1.96786297
112Ileus (HP:0002595)1.95142650
113Medial flaring of the eyebrow (HP:0010747)1.94685270
114Abnormality of renin-angiotensin system (HP:0000847)1.93254834
115Hypsarrhythmia (HP:0002521)1.91152994
116Hyperextensible skin (HP:0000974)1.90977626
117Decreased circulating renin level (HP:0003351)1.90200128
118Abnormality of the right ventricle (HP:0001707)1.89857654
119Broad-based gait (HP:0002136)1.89072322
120Abnormality of the 1st metacarpal (HP:0010009)1.88640639
121Hyperaldosteronism (HP:0000859)1.88179698
122Abnormal urine output (HP:0012590)1.87034209
123Tetany (HP:0001281)1.86893143
124Postural tremor (HP:0002174)1.86827885
125Male infertility (HP:0003251)1.86420537
126Blue sclerae (HP:0000592)1.85500216
127Increased connective tissue (HP:0009025)1.84249640
128Tubular atrophy (HP:0000092)1.84211067
129Sleep apnea (HP:0010535)1.83938093
130Abnormality of the renal cortex (HP:0011035)1.83550054
131Abnormality of the fingertips (HP:0001211)1.82787822
132Laryngomalacia (HP:0001601)1.82202436
133Scapular winging (HP:0003691)1.81996316
134Short humerus (HP:0005792)1.81892003
135Hypokalemia (HP:0002900)1.81560743
136Congenital glaucoma (HP:0001087)1.80845324
137Papilledema (HP:0001085)1.80366501
138Renal cortical cysts (HP:0000803)1.79732491
139Renal salt wasting (HP:0000127)1.78586742
140Limb hypertonia (HP:0002509)1.78504743
141Abnormality of ocular smooth pursuit (HP:0000617)1.77426879
142Stage 5 chronic kidney disease (HP:0003774)1.77260156
143Intention tremor (HP:0002080)1.76757842
144Renal tubular acidosis (HP:0001947)1.76490283
145Mitral valve prolapse (HP:0001634)1.76374242
146Hypoplastic nipples (HP:0002557)1.74899542
147Neoplasm of the adrenal gland (HP:0100631)1.74409250
148Vertebral compression fractures (HP:0002953)1.74398161
149Gait imbalance (HP:0002141)1.74320551
150Gout (HP:0001997)1.74088143
151Fat malabsorption (HP:0002630)1.73625005
152Abnormality of the distal phalanges of the toes (HP:0010182)1.73203356
153Bowel diverticulosis (HP:0005222)1.72731746
154Type II lissencephaly (HP:0007260)1.71798736
155Proximal tubulopathy (HP:0000114)1.71637793
156Hand muscle atrophy (HP:0009130)1.71223668
157Hypomagnesemia (HP:0002917)1.71141595
158Congenital primary aphakia (HP:0007707)1.70666892
159Bifid scrotum (HP:0000048)1.70533987
160Urinary bladder sphincter dysfunction (HP:0002839)1.70217362
161Absence seizures (HP:0002121)1.69358191
162Elbow flexion contracture (HP:0002987)1.69319497
163Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.69213241
164Truncal ataxia (HP:0002078)1.68961098
165Pheochromocytoma (HP:0002666)1.68885198
166Buphthalmos (HP:0000557)1.68211559
167Morphological abnormality of the inner ear (HP:0011390)1.67495858
168Lymphangioma (HP:0100764)1.67381132
169Methylmalonic acidemia (HP:0002912)1.67335732
170Poor coordination (HP:0002370)1.67045016
171Aqueductal stenosis (HP:0002410)1.66874813
172Infantile muscular hypotonia (HP:0008947)1.65282901
173Vascular calcification (HP:0004934)1.64184905
174Turricephaly (HP:0000262)1.63780003
175Abnormality of incisor morphology (HP:0011063)1.63714584
176Dialeptic seizures (HP:0011146)1.63130793
177Distal upper limb amyotrophy (HP:0007149)1.62660625
178Upper limb amyotrophy (HP:0009129)1.62660625
179Shawl scrotum (HP:0000049)1.62170878
180Tachypnea (HP:0002789)1.61850029
181Clumsiness (HP:0002312)1.61062790
182Hypoplasia of the pons (HP:0012110)1.60827000
183Abnormality of vitamin metabolism (HP:0100508)1.60620145
184Abnormality of potassium homeostasis (HP:0011042)1.60000664
185Cystic liver disease (HP:0006706)1.59322210
186Abnormality of the proximal phalanges of the hand (HP:0009834)1.58933023
187Fibular aplasia (HP:0002990)1.58779621
188Tented upper lip vermilion (HP:0010804)1.58582970
189Sensorimotor neuropathy (HP:0007141)1.57466752
190Abnormality of the odontoid process (HP:0003310)1.57049107
191Broad face (HP:0000283)1.55573502
192Osteomalacia (HP:0002749)1.55320415
193Wide anterior fontanel (HP:0000260)1.55081147
194Aneurysm (HP:0002617)1.54729555
195Aplasia/hypoplasia of the humerus (HP:0006507)1.54496188
196Congenital stationary night blindness (HP:0007642)1.54115641

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT37.23327437
2LMTK24.05097191
3LATS13.72402187
4FRK3.71313637
5EPHA23.53677659
6TNK23.22207142
7DDR22.93155194
8WNK42.41728591
9TTN2.38721934
10GRK12.38592854
11PDGFRA2.34076708
12STK38L2.22015600
13FER2.15465050
14OXSR12.15108278
15PTK22.10818877
16TAF12.04284447
17WNK31.90995918
18LATS21.84441358
19STK391.83768411
20PAK31.82393550
21EEF2K1.75279701
22INSRR1.61285024
23BRSK21.61024741
24WNK11.58033807
25ZAK1.52577765
26SIK11.51865758
27MET1.49404795
28PRKG21.47165052
29TRPM71.46947621
30MST41.43491691
31ERBB41.37981028
32STK381.37649380
33DAPK21.34037083
34STK31.33964825
35NTRK11.33372397
36NEK91.29887515
37MAPK131.28768574
38ROCK11.28760693
39EPHB21.25061230
40FGFR21.23089871
41EIF2AK11.21468663
42PTK61.17644162
43CAMKK21.17123632
44ACVR1B1.15913208
45ERBB31.15445405
46PAK41.13321504
47PRKAA21.12787639
48TAOK11.12115060
49PAK21.10383767
50MST1R1.08240968
51BMPR1B1.06030219
52MAP3K21.05165971
53MOS1.05056862
54BMX1.03588060
55BCR0.99309064
56TTK0.97612141
57RIPK10.94976416
58PRKD30.94560207
59FGFR10.92732309
60PHKG20.87177160
61PHKG10.87177160
62SGK4940.85286336
63SGK2230.85286336
64SCYL20.85055721
65TRIB30.82594662
66PDGFRB0.80833429
67ADRBK20.78869699
68EIF2AK30.74667218
69ROCK20.74420382
70ADRBK10.74335878
71ICK0.72882396
72CDC42BPA0.71755306
73MKNK20.71517240
74MYLK0.69893207
75SGK30.69248710
76MTOR0.67410750
77LIMK10.67365646
78MAPKAPK30.66697106
79NTRK30.65643860
80MAP2K10.65483364
81PRKCE0.65231534
82PASK0.64726703
83NUAK10.63256678
84SGK20.61614571
85STK100.60669685
86INSR0.60410899
87PLK20.59998663
88CAMKK10.58883517
89SMG10.58619226
90CAMK10.58067733
91LRRK20.57898040
92CAMK1D0.55473112
93PLK30.54102109
94CAMK2D0.53212351
95MAP3K130.53091556
96PRKD20.53050141
97MAP3K40.52573541
98MAP4K20.52025457
99MINK10.50603940
100RPS6KA40.50536576
101TESK10.50323971
102PIK3CA0.49649936
103PNCK0.49005680
104CAMK1G0.48554828
105MARK20.46174357
106PRKCI0.46059963
107ERBB20.44368566
108MAP3K90.44284186
109MELK0.44085419
110SGK10.43982084
111PAK60.43717003
112TAOK30.43614432
113PKN20.43428669
114CSNK1A1L0.42929711
115STK110.40277166
116SRC0.39735648
117DMPK0.39679935
118PRKCH0.38690223
119CSNK1G10.38055813
120GRK50.37707254
121EPHB10.37510963
122MAPK150.36978242
123SIK30.36276266
124CAMK2B0.35005395
125VRK20.34627909
126NLK0.34564277
127PRKAA10.34441284
128CSNK1E0.33970869
129DAPK10.31741088
130RET0.31426170
131HIPK20.30532298
132PRKCZ0.29690095
133CDK60.29513907
134AKT20.29376734
135DYRK1B0.28638912
136PRKDC0.28581949
137PRKG10.28448779
138EPHA30.28381600
139CASK0.28097238
140MAPK10.27368261
141CSNK1A10.26712548
142MAP2K40.26638601
143BRSK10.25134109
144CSNK1G30.23936857
145MAP2K60.23892527
146GSK3A0.21391727
147PRKCG0.19906818
148TSSK60.19659129
149MAPKAPK50.19146006
150EIF2AK20.18418551
151CHUK0.18410134

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000613.66428471
2ECM-receptor interaction_Homo sapiens_hsa045122.84901554
3Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.60051268
4Propanoate metabolism_Homo sapiens_hsa006402.33385483
5Vitamin B6 metabolism_Homo sapiens_hsa007502.20658994
6Focal adhesion_Homo sapiens_hsa045102.17985521
7Histidine metabolism_Homo sapiens_hsa003402.14360344
8Fatty acid metabolism_Homo sapiens_hsa012122.12628627
9Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002502.01653489
10Phototransduction_Homo sapiens_hsa047441.97886951
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.92812421
12Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.88035184
13Hippo signaling pathway_Homo sapiens_hsa043901.86305092
14Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.86106455
15Adherens junction_Homo sapiens_hsa045201.86027013
16Primary bile acid biosynthesis_Homo sapiens_hsa001201.81712522
17Proteoglycans in cancer_Homo sapiens_hsa052051.81374309
18Tryptophan metabolism_Homo sapiens_hsa003801.80680236
19Arginine and proline metabolism_Homo sapiens_hsa003301.73880225
20Melanoma_Homo sapiens_hsa052181.72297879
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.71419036
22Phenylalanine metabolism_Homo sapiens_hsa003601.70421948
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.66137208
24beta-Alanine metabolism_Homo sapiens_hsa004101.56813572
25Sulfur metabolism_Homo sapiens_hsa009201.54973957
26Renin-angiotensin system_Homo sapiens_hsa046141.53940411
27Bladder cancer_Homo sapiens_hsa052191.53765038
28Protein digestion and absorption_Homo sapiens_hsa049741.50632895
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.50588778
30MicroRNAs in cancer_Homo sapiens_hsa052061.42492777
31Tight junction_Homo sapiens_hsa045301.41802284
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.37921164
33Hedgehog signaling pathway_Homo sapiens_hsa043401.37588160
34Vibrio cholerae infection_Homo sapiens_hsa051101.37538691
35Pyruvate metabolism_Homo sapiens_hsa006201.37129443
36* Mineral absorption_Homo sapiens_hsa049781.36685109
37Axon guidance_Homo sapiens_hsa043601.35084962
38Selenocompound metabolism_Homo sapiens_hsa004501.32976976
39Thyroid hormone synthesis_Homo sapiens_hsa049181.32636661
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.32179085
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.28953253
42Small cell lung cancer_Homo sapiens_hsa052221.27267471
43Fatty acid degradation_Homo sapiens_hsa000711.27071138
44Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.26036922
45Prostate cancer_Homo sapiens_hsa052151.25397933
46Glioma_Homo sapiens_hsa052141.25357987
47Peroxisome_Homo sapiens_hsa041461.25140117
48Lysine degradation_Homo sapiens_hsa003101.24817905
49Basal cell carcinoma_Homo sapiens_hsa052171.24729311
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.23901273
51ABC transporters_Homo sapiens_hsa020101.23814496
52Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.23387315
53Gastric acid secretion_Homo sapiens_hsa049711.23253651
54TGF-beta signaling pathway_Homo sapiens_hsa043501.23035455
55Dilated cardiomyopathy_Homo sapiens_hsa054141.22587884
56Ovarian steroidogenesis_Homo sapiens_hsa049131.16741545
57PI3K-Akt signaling pathway_Homo sapiens_hsa041511.12839021
58Taste transduction_Homo sapiens_hsa047421.12292332
59Bile secretion_Homo sapiens_hsa049761.09776503
60Ether lipid metabolism_Homo sapiens_hsa005651.09720021
61Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.09343765
62Insulin secretion_Homo sapiens_hsa049111.07799002
63Long-term depression_Homo sapiens_hsa047301.07390392
64Cysteine and methionine metabolism_Homo sapiens_hsa002701.07101313
652-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.04024703
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.02905643
67Protein export_Homo sapiens_hsa030601.02111143
68Regulation of actin cytoskeleton_Homo sapiens_hsa048101.02053153
69Amoebiasis_Homo sapiens_hsa051461.01128129
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.00348158
71Linoleic acid metabolism_Homo sapiens_hsa005910.98774422
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.98415909
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.97372641
74Cocaine addiction_Homo sapiens_hsa050300.95567433
75Wnt signaling pathway_Homo sapiens_hsa043100.93005008
76mTOR signaling pathway_Homo sapiens_hsa041500.92363070
77Synaptic vesicle cycle_Homo sapiens_hsa047210.92156733
78Gap junction_Homo sapiens_hsa045400.91709689
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.90088245
80Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88270562
81Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.85700226
82AMPK signaling pathway_Homo sapiens_hsa041520.84862123
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.84310179
84Rap1 signaling pathway_Homo sapiens_hsa040150.83875496
85GABAergic synapse_Homo sapiens_hsa047270.82927611
86Nicotine addiction_Homo sapiens_hsa050330.82864528
87Tyrosine metabolism_Homo sapiens_hsa003500.82629918
88Chronic myeloid leukemia_Homo sapiens_hsa052200.80051540
89Sphingolipid metabolism_Homo sapiens_hsa006000.79034149
90Aldosterone synthesis and secretion_Homo sapiens_hsa049250.76657400
91Pancreatic cancer_Homo sapiens_hsa052120.76444891
92Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.76004192
93Arginine biosynthesis_Homo sapiens_hsa002200.75790142
94Steroid biosynthesis_Homo sapiens_hsa001000.74649275
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.73988174
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73440839
97Long-term potentiation_Homo sapiens_hsa047200.71888130
98Collecting duct acid secretion_Homo sapiens_hsa049660.71650657
99One carbon pool by folate_Homo sapiens_hsa006700.70517784
100AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70381983
101Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.70132080
102Retinol metabolism_Homo sapiens_hsa008300.69855052
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69781613
104Dopaminergic synapse_Homo sapiens_hsa047280.69751913
105Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69142031
106Salivary secretion_Homo sapiens_hsa049700.68673750
107Pentose and glucuronate interconversions_Homo sapiens_hsa000400.68369283
108Ras signaling pathway_Homo sapiens_hsa040140.68229057
109Serotonergic synapse_Homo sapiens_hsa047260.67654026
110Estrogen signaling pathway_Homo sapiens_hsa049150.67115567
111Glutamatergic synapse_Homo sapiens_hsa047240.67067700
112Leukocyte transendothelial migration_Homo sapiens_hsa046700.66759879
113Melanogenesis_Homo sapiens_hsa049160.66452659
114Renal cell carcinoma_Homo sapiens_hsa052110.65335336
115Pancreatic secretion_Homo sapiens_hsa049720.64868534
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63760991
117Type II diabetes mellitus_Homo sapiens_hsa049300.63717848
118Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.63123871
119ErbB signaling pathway_Homo sapiens_hsa040120.62966485
120Insulin resistance_Homo sapiens_hsa049310.62753152
121Circadian rhythm_Homo sapiens_hsa047100.62115754
122Endometrial cancer_Homo sapiens_hsa052130.61605817
123Choline metabolism in cancer_Homo sapiens_hsa052310.61509773
124GnRH signaling pathway_Homo sapiens_hsa049120.61426665
125Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60959124
126Cholinergic synapse_Homo sapiens_hsa047250.60782024
127Pathways in cancer_Homo sapiens_hsa052000.60718685
128Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60519333
129Glycosaminoglycan degradation_Homo sapiens_hsa005310.59958868
130Dorso-ventral axis formation_Homo sapiens_hsa043200.58395636
131Vitamin digestion and absorption_Homo sapiens_hsa049770.56440104
132Basal transcription factors_Homo sapiens_hsa030220.56171612
133Circadian entrainment_Homo sapiens_hsa047130.55686762
134Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54861165
135Butanoate metabolism_Homo sapiens_hsa006500.53682188
136Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53485206
137cAMP signaling pathway_Homo sapiens_hsa040240.53259839
138Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51636408
139Nitrogen metabolism_Homo sapiens_hsa009100.51289423
140Fructose and mannose metabolism_Homo sapiens_hsa000510.51186453
141Phagosome_Homo sapiens_hsa041450.50908086
142Amphetamine addiction_Homo sapiens_hsa050310.50040101
143FoxO signaling pathway_Homo sapiens_hsa040680.50019603
144Steroid hormone biosynthesis_Homo sapiens_hsa001400.49894943
145cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49857615
146Renin secretion_Homo sapiens_hsa049240.49486280
147Fatty acid elongation_Homo sapiens_hsa000620.49217597
148Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49084576
149Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47627230
150Glucagon signaling pathway_Homo sapiens_hsa049220.46618068
151Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46332872
152Metabolic pathways_Homo sapiens_hsa011000.45644298
153Phospholipase D signaling pathway_Homo sapiens_hsa040720.45163809
154PPAR signaling pathway_Homo sapiens_hsa033200.44366255
155Glycerophospholipid metabolism_Homo sapiens_hsa005640.39755098

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