STAT5A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.24697619
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.24697619
3antigen processing and presentation of endogenous antigen (GO:0019883)6.03338916
4* positive regulation of gamma-delta T cell activation (GO:0046645)5.04197802
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.84354958
6NIK/NF-kappaB signaling (GO:0038061)4.62615229
7regulation of interleukin-12 biosynthetic process (GO:0045075)4.57708245
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.28610572
9negative regulation of cell killing (GO:0031342)4.28610572
10* positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.15354169
11positive regulation by symbiont of host defense response (GO:0052509)4.12591466
12modulation by symbiont of host defense response (GO:0052031)4.12591466
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.12591466
14positive regulation by organism of defense response of other organism involved in symbiotic interact4.12591466
15modulation by symbiont of host immune response (GO:0052553)4.12591466
16* positive regulation of natural killer cell differentiation (GO:0032825)3.90842867
17* negative regulation of erythrocyte differentiation (GO:0045647)3.86713650
18myeloid dendritic cell differentiation (GO:0043011)3.85423547
19* regulation of gamma-delta T cell differentiation (GO:0045586)3.79931928
20antigen processing and presentation via MHC class Ib (GO:0002475)3.77545252
21* regulation of gamma-delta T cell activation (GO:0046643)3.77037997
22myeloid dendritic cell activation (GO:0001773)3.74419316
23regulation of T-helper 1 cell differentiation (GO:0045625)3.72907431
24macrophage activation involved in immune response (GO:0002281)3.71010964
25negative T cell selection (GO:0043383)3.65768202
26negative thymic T cell selection (GO:0045060)3.62790505
27response to type I interferon (GO:0034340)3.61873973
28lipopolysaccharide-mediated signaling pathway (GO:0031663)3.60215878
29type I interferon signaling pathway (GO:0060337)3.59091025
30cellular response to type I interferon (GO:0071357)3.59091025
31regulation of B cell receptor signaling pathway (GO:0050855)3.56876090
32regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.53751876
33negative regulation of T cell mediated immunity (GO:0002710)3.49865826
34detection of other organism (GO:0098543)3.44704592
35response to interleukin-15 (GO:0070672)3.43661494
36positive regulation of humoral immune response (GO:0002922)3.43578270
37detection of bacterium (GO:0016045)3.37161174
38negative regulation of cytokine production involved in immune response (GO:0002719)3.35533869
39* JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.34025031
40regulation of alpha-beta T cell proliferation (GO:0046640)3.29375503
41defense response to protozoan (GO:0042832)3.29113443
42positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.28119163
43* positive regulation of interleukin-2 production (GO:0032743)3.25679326
44regulation of vitamin D biosynthetic process (GO:0060556)3.23747632
45positive regulation of interferon-alpha production (GO:0032727)3.23531995
46response to protozoan (GO:0001562)3.22983433
47positive regulation of alpha-beta T cell proliferation (GO:0046641)3.19190737
48positive regulation of isotype switching (GO:0045830)3.18694427
49immunoglobulin mediated immune response (GO:0016064)3.18184202
50regulation of interferon-beta biosynthetic process (GO:0045357)3.15284325
51B cell mediated immunity (GO:0019724)3.14720526
52positive regulation of interleukin-17 production (GO:0032740)3.14678976
53response to muramyl dipeptide (GO:0032495)3.14389066
54regulation of T-helper cell differentiation (GO:0045622)3.13535252
55regulation of RIG-I signaling pathway (GO:0039535)3.12587449
56regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.12307108
57positive thymic T cell selection (GO:0045059)3.10562147
58interferon-gamma-mediated signaling pathway (GO:0060333)3.09067409
59positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.08449863
60* regulation of interleukin-2 biosynthetic process (GO:0045076)3.08349613
61positive regulation of antigen processing and presentation (GO:0002579)3.08203780
62regulation of interferon-alpha production (GO:0032647)3.07232817
63positive regulation of B cell mediated immunity (GO:0002714)3.06816090
64positive regulation of immunoglobulin mediated immune response (GO:0002891)3.06816090
65regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.05346913
66positive regulation of interleukin-12 production (GO:0032735)3.05026858
67B cell receptor signaling pathway (GO:0050853)3.00841880
68response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.96722151
69response to host immune response (GO:0052572)2.96722151
70neutrophil activation involved in immune response (GO:0002283)2.96396248
71negative regulation of lymphocyte mediated immunity (GO:0002707)2.95673889
72interferon-gamma production (GO:0032609)2.93681138
73dendritic cell differentiation (GO:0097028)2.93374988
74myeloid cell activation involved in immune response (GO:0002275)2.91532016
75detection of external biotic stimulus (GO:0098581)2.91348082
76positive regulation of T-helper cell differentiation (GO:0045624)2.90528360
77regulation of immunoglobulin secretion (GO:0051023)2.90057426
78T cell migration (GO:0072678)2.89683504
79positive regulation of T cell mediated cytotoxicity (GO:0001916)2.88860783
80CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.88273179
81leukocyte aggregation (GO:0070486)2.88153588
82cellular extravasation (GO:0045123)2.88083615
83positive regulation of type 2 immune response (GO:0002830)2.87852857
84positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.86857882
85response to interferon-beta (GO:0035456)2.85994121
86thymic T cell selection (GO:0045061)2.85508581
87regulation of interleukin-12 production (GO:0032655)2.84886435
88Arp2/3 complex-mediated actin nucleation (GO:0034314)2.84746696
89regulation of type I interferon-mediated signaling pathway (GO:0060338)2.84297103
90regulation of T cell tolerance induction (GO:0002664)2.83841695
91T-helper 1 type immune response (GO:0042088)2.83353149
92regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.82521424
93positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.82454309
94* positive regulation of B cell differentiation (GO:0045579)2.81520619
95positive regulation of T cell cytokine production (GO:0002726)2.80939243
96negative regulation of leukocyte mediated immunity (GO:0002704)2.79874939
97regulation of mast cell degranulation (GO:0043304)2.79616460
98response to peptidoglycan (GO:0032494)2.77867718
99T cell selection (GO:0045058)2.77515441
100response to interferon-alpha (GO:0035455)2.76592435
101positive regulation of DNA recombination (GO:0045911)2.76527707
102regulation of response to interferon-gamma (GO:0060330)2.76023166
103positive regulation of macrophage differentiation (GO:0045651)2.75722909
104regulation of hypersensitivity (GO:0002883)2.73626469
105ribosomal small subunit assembly (GO:0000028)2.73438024
106negative regulation of interleukin-12 production (GO:0032695)2.73259760
107mature B cell differentiation involved in immune response (GO:0002313)2.72381243
108regulation of T-helper 1 type immune response (GO:0002825)2.72332084
109negative regulation of innate immune response (GO:0045824)2.71948479
110detection of molecule of bacterial origin (GO:0032490)2.71629936
111response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.71145157
112response to host (GO:0075136)2.71145157
113response to host defenses (GO:0052200)2.71145157
114tolerance induction (GO:0002507)2.70884746
115positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.70871327
116negative regulation of production of molecular mediator of immune response (GO:0002701)2.70563022
117* regulation of B cell differentiation (GO:0045577)2.70139232
118positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.70102090
119regulation of necroptotic process (GO:0060544)2.69875506
120negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.68554752
121regulation of tolerance induction (GO:0002643)2.67764846
122mature B cell differentiation (GO:0002335)2.66968145
123cellular response to interferon-gamma (GO:0071346)2.66789633
124regulation of dendritic cell antigen processing and presentation (GO:0002604)2.66672985
125regulation of vitamin metabolic process (GO:0030656)2.66563535
126* regulation of natural killer cell differentiation (GO:0032823)2.65088427
127cellular response to interferon-beta (GO:0035458)2.64694675
128regulation of chronic inflammatory response (GO:0002676)2.64667603
129cellular response to zinc ion (GO:0071294)2.64381521
130growth hormone receptor signaling pathway (GO:0060396)2.64057665
131* positive regulation of activated T cell proliferation (GO:0042104)2.63859655
132* positive regulation of cytokine biosynthetic process (GO:0042108)2.63565319
133regulation of regulatory T cell differentiation (GO:0045589)2.63151992
134tyrosine phosphorylation of STAT protein (GO:0007260)2.62766310
135lymph node development (GO:0048535)2.60047285
136regulation of antigen processing and presentation (GO:0002577)2.58646709
137* regulation of interleukin-2 production (GO:0032663)2.57908589
138T-helper cell differentiation (GO:0042093)2.57401073
139CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.57401073
140germinal center formation (GO:0002467)2.56819218
141modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.56630290

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.20097769
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.24501351
3* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.93560223
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.85160993
5E2F7_22180533_ChIP-Seq_HELA_Human3.82923686
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.67092814
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.51125941
8IRF8_21731497_ChIP-ChIP_J774_Mouse3.43670775
9EGR1_19374776_ChIP-ChIP_THP-1_Human3.15571767
10* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.13076939
11* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.78703310
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.71508462
13* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.71027522
14MYC_22102868_ChIP-Seq_BL_Human2.64710206
15SCL_19346495_ChIP-Seq_HPC-7_Human2.62976514
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.61871298
17GATA1_22025678_ChIP-Seq_K562_Human2.56081184
18NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.52751931
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.50940031
20IRF8_27001747_Chip-Seq_BMDM_Mouse2.47037849
21* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.45639932
22VDR_21846776_ChIP-Seq_THP-1_Human2.37586752
23MYB_26560356_Chip-Seq_TH2_Human2.34738979
24* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.32857858
25MAF_26560356_Chip-Seq_TH1_Human2.25935069
26STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.16811473
27MYB_26560356_Chip-Seq_TH1_Human2.13880446
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.10528002
29RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.07698547
30RUNX_20019798_ChIP-Seq_JUKART_Human2.07274922
31SPI1_23547873_ChIP-Seq_NB4_Human2.02004250
32* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.01137196
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.93792004
34VDR_24763502_ChIP-Seq_THP-1_Human1.91877581
35BRD4_27068464_Chip-Seq_AML-cells_Mouse1.84714183
36GATA1_19941826_ChIP-Seq_K562_Human1.83014271
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.80014492
38* RUNX1_22412390_ChIP-Seq_EML_Mouse1.75146094
39UTX_26944678_Chip-Seq_JUKART_Human1.73829620
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.72507456
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.71696283
42* TCF7_22412390_ChIP-Seq_EML_Mouse1.68027019
43EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.67616114
44STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.67247437
45VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.66462149
46* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.64011545
47LXR_22292898_ChIP-Seq_THP-1_Human1.54749153
48* MAF_26560356_Chip-Seq_TH2_Human1.43864858
49GATA2_22383799_ChIP-Seq_G1ME_Mouse1.42133761
50E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.41848354
51GATA3_27048872_Chip-Seq_THYMUS_Human1.40017492
52MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.37347221
53SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.37129232
54Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.35906196
55TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.31970664
56* PU_27001747_Chip-Seq_BMDM_Mouse1.31850275
57LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.31390493
58SPI1_23127762_ChIP-Seq_K562_Human1.31293139
59* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.29216914
60CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.28566477
61GATA1_22383799_ChIP-Seq_G1ME_Mouse1.27759318
62ELF1_17652178_ChIP-ChIP_JURKAT_Human1.27181107
63* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.25477388
64ELK3_25401928_ChIP-Seq_HUVEC_Human1.24900795
65ERG_20887958_ChIP-Seq_HPC-7_Mouse1.24133420
66PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21467974
67GATA2_19941826_ChIP-Seq_K562_Human1.19427146
68* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.16564409
69ELF1_20517297_ChIP-Seq_JURKAT_Human1.14030601
70CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13204329
71CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13152912
72HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12520980
73TP63_17297297_ChIP-ChIP_HaCaT_Human1.12456638
74* PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.12207504
75LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.11914627
76GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.09734266
77GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08007633
78BCL6_27268052_Chip-Seq_Bcells_Human1.06254464
79BCOR_27268052_Chip-Seq_Bcells_Human1.06040116
80KDM2B_26808549_Chip-Seq_JURKAT_Human1.05047298
81GATA3_26560356_Chip-Seq_TH2_Human1.04621304
82GATA1_19941827_ChIP-Seq_MEL_Mouse1.04338498
83KDM2B_26808549_Chip-Seq_DND41_Human1.03114584
84* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.02402322
85SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98509171
86SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.97335604
87* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96900511
88* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96097573
89NCOR1_26117541_ChIP-Seq_K562_Human0.94910143
90KDM2B_26808549_Chip-Seq_SUP-B15_Human0.94361835
91CIITA_25753668_ChIP-Seq_RAJI_Human0.93713822
92TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92309086
93VDR_23849224_ChIP-Seq_CD4+_Human0.92236594
94SA1_27219007_Chip-Seq_ERYTHROID_Human0.91759179
95VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.91747497
96E2F4_17652178_ChIP-ChIP_JURKAT_Human0.89689552
97* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86982363
98* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86389314
99PU.1_20513432_ChIP-Seq_Bcells_Mouse0.83486253
100GATA2_21666600_ChIP-Seq_HMVEC_Human0.83257090
101MYC_18555785_ChIP-Seq_MESCs_Mouse0.83248949
102VDR_24787735_ChIP-Seq_THP-1_Human0.83198978
103CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83136362
104TFEB_21752829_ChIP-Seq_HELA_Human0.80507035
105NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.79838809
106PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79677935
107SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.78904339
108PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.78799474
109KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.78392287
110THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.78005712
111ELK1_19687146_ChIP-ChIP_HELA_Human0.77660850
112CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.75827389
113ETS1_22383799_ChIP-Seq_G1ME_Mouse0.75438588
114STAT3_1855785_ChIP-Seq_MESCs_Mouse0.74734082
115E2F1_21310950_ChIP-Seq_MCF-7_Human0.74590282
116FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.74536001
117* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.74394803

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.01935756
2MP0000685_abnormal_immune_system3.66489055
3MP0009785_altered_susceptibility_to3.12537155
4MP0003436_decreased_susceptibility_to3.05853842
5MP0005671_abnormal_response_to3.04693233
6MP0001790_abnormal_immune_system2.86933001
7MP0005387_immune_system_phenotype2.86933001
8MP0002166_altered_tumor_susceptibility2.71525682
9MP0003763_abnormal_thymus_physiology2.71009769
10MP0005000_abnormal_immune_tolerance2.70001944
11MP0001800_abnormal_humoral_immune2.65473197
12MP0002148_abnormal_hypersensitivity_rea2.65193413
13MP0005025_abnormal_response_to2.54315094
14MP0002396_abnormal_hematopoietic_system2.42897059
15MP0002452_abnormal_antigen_presenting2.40649919
16MP0002006_tumorigenesis2.40091490
17MP0003300_gastrointestinal_ulcer2.38247605
18* MP0002723_abnormal_immune_serum2.37824359
19MP0001853_heart_inflammation2.35773090
20MP0003724_increased_susceptibility_to2.29821613
21MP0005451_abnormal_body_composition2.27680388
22MP0010155_abnormal_intestine_physiology2.23752186
23* MP0001819_abnormal_immune_cell2.21044149
24MP0002254_reproductive_system_inflammat2.20580296
25* MP0002420_abnormal_adaptive_immunity2.19843288
26MP0003303_peritoneal_inflammation2.17049952
27* MP0002419_abnormal_innate_immunity2.16572101
28MP0004510_myositis2.15653927
29MP0002405_respiratory_system_inflammati2.12497491
30MP0001873_stomach_inflammation2.11909950
31* MP0002398_abnormal_bone_marrow2.11172100
32MP0006082_CNS_inflammation2.04833882
33MP0009333_abnormal_splenocyte_physiolog1.97867698
34MP0005397_hematopoietic_system_phenotyp1.94320994
35MP0001545_abnormal_hematopoietic_system1.94320994
36MP0005310_abnormal_salivary_gland1.93407708
37MP0005464_abnormal_platelet_physiology1.89878003
38* MP0000716_abnormal_immune_system1.88335580
39MP0004947_skin_inflammation1.82305654
40MP0004808_abnormal_hematopoietic_stem1.80317135
41* MP0001845_abnormal_inflammatory_respons1.75173364
42MP0003172_abnormal_lysosome_physiology1.74617854
43* MP0002722_abnormal_immune_system1.68297413
44* MP0000689_abnormal_spleen_morphology1.68218401
45MP0003866_abnormal_defecation1.63389168
46* MP0002429_abnormal_blood_cell1.60918665
47MP0009278_abnormal_bone_marrow1.59228278
48MP0009764_decreased_sensitivity_to1.50114717
49MP0001533_abnormal_skeleton_physiology1.47167997
50MP0010352_gastrointestinal_tract_polyps1.47003462
51* MP0000703_abnormal_thymus_morphology1.46972482
52MP0003075_altered_response_to1.44337978
53MP0002138_abnormal_hepatobiliary_system1.36445629
54* MP0008469_abnormal_protein_level1.35089498
55MP0003806_abnormal_nucleotide_metabolis1.30657938
56MP0000490_abnormal_crypts_of1.26096158
57MP0000465_gastrointestinal_hemorrhage1.23355439
58MP0008004_abnormal_stomach_pH1.23240063
59MP0000858_altered_metastatic_potential1.22010440
60MP0002933_joint_inflammation1.19777822
61MP0003448_altered_tumor_morphology1.17051494
62MP0001348_abnormal_lacrimal_gland1.13842464
63MP0000604_amyloidosis1.11364341
64MP0008057_abnormal_DNA_replication1.03911174
65MP0008260_abnormal_autophagy1.03789886
66MP0002139_abnormal_hepatobiliary_system1.00821410
67MP0005666_abnormal_adipose_tissue0.99103174
68* MP0001881_abnormal_mammary_gland0.95228358
69MP0005076_abnormal_cell_differentiation0.94162950
70MP0005174_abnormal_tail_pigmentation0.93937988
71MP0000343_altered_response_to0.93637442
72MP0010307_abnormal_tumor_latency0.92924389
73MP0002998_abnormal_bone_remodeling0.92181007
74* MP0002019_abnormal_tumor_incidence0.91724768
75MP0003690_abnormal_glial_cell0.90225816
76MP0002877_abnormal_melanocyte_morpholog0.88914902
77MP0002132_abnormal_respiratory_system0.86305392
78MP0009763_increased_sensitivity_to0.85427831
79MP0002332_abnormal_exercise_endurance0.83644876
80MP0009765_abnormal_xenobiotic_induced0.79463983
81MP0005164_abnormal_response_to0.77113299
82MP0003656_abnormal_erythrocyte_physiolo0.76857989
83MP0003566_abnormal_cell_adhesion0.75366896
84MP0005167_abnormal_blood-brain_barrier0.74264933
85MP0002163_abnormal_gland_morphology0.73366190
86MP0004883_abnormal_blood_vessel0.72236045
87MP0002009_preneoplasia0.71333964
88MP0005075_abnormal_melanosome_morpholog0.70893203
89MP0003828_pulmonary_edema0.70761840
90MP0001663_abnormal_digestive_system0.70582574
91MP0000371_diluted_coat_color0.70522576
92MP0003186_abnormal_redox_activity0.70489043
93MP0005023_abnormal_wound_healing0.70262265
94* MP0000609_abnormal_liver_physiology0.70115531
95MP0003453_abnormal_keratinocyte_physiol0.68667690
96MP0004381_abnormal_hair_follicle0.67953150
97MP0001851_eye_inflammation0.66086534
98* MP0005535_abnormal_body_temperature0.65797033
99MP0002136_abnormal_kidney_physiology0.65744605
100MP0005058_abnormal_lysosome_morphology0.64169704
101MP0005390_skeleton_phenotype0.62982573
102MP0000249_abnormal_blood_vessel0.62646493
103MP0006054_spinal_hemorrhage0.61260374
104MP0005165_increased_susceptibility_to0.60779317
105MP0008874_decreased_physiological_sensi0.59409226
106MP0009115_abnormal_fat_cell0.59226643
107MP0005375_adipose_tissue_phenotype0.58677031
108MP0005166_decreased_susceptibility_to0.58566334
109MP0003693_abnormal_embryo_hatching0.57950545
110* MP0000627_abnormal_mammary_gland0.57486872
111MP0003795_abnormal_bone_structure0.56878935
112MP0003191_abnormal_cellular_cholesterol0.56490698
113MP0003221_abnormal_cardiomyocyte_apopto0.56305530
114MP0000598_abnormal_liver_morphology0.55439160
115MP0009840_abnormal_foam_cell0.53617169
116MP0004130_abnormal_muscle_cell0.53562613
117MP0004782_abnormal_surfactant_physiolog0.53185365
118MP0003091_abnormal_cell_migration0.52907407
119MP0001216_abnormal_epidermal_layer0.52062514
120MP0000767_abnormal_smooth_muscle0.51606452
121MP0004185_abnormal_adipocyte_glucose0.51531209

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.98811032
2Recurrent fungal infections (HP:0002841)4.70856626
3Elevated erythrocyte sedimentation rate (HP:0003565)4.66210864
4Myositis (HP:0100614)4.49040358
5Recurrent viral infections (HP:0004429)4.44282067
6Chronic otitis media (HP:0000389)4.36584333
7Thrombocytosis (HP:0001894)4.27103478
8Recurrent abscess formation (HP:0002722)4.04007654
9Chronic mucocutaneous candidiasis (HP:0002728)3.84350965
10Recurrent cutaneous fungal infections (HP:0011370)3.84350965
11Recurrent bacterial skin infections (HP:0005406)3.83394203
12Abnormal delayed hypersensitivity skin test (HP:0002963)3.82358637
13Optic neuritis (HP:0100653)3.77223879
14Retrobulbar optic neuritis (HP:0100654)3.77223879
15Orchitis (HP:0100796)3.75486701
16Abnormality of glycolipid metabolism (HP:0010969)3.72818341
17Abnormality of liposaccharide metabolism (HP:0010968)3.72818341
18Abnormality of glycosphingolipid metabolism (HP:0004343)3.72818341
19Mediastinal lymphadenopathy (HP:0100721)3.64080619
20Abnormality of T cell number (HP:0011839)3.56721712
21Nasal polyposis (HP:0100582)3.55103833
22Panhypogammaglobulinemia (HP:0003139)3.53839168
23T lymphocytopenia (HP:0005403)3.44845250
24IgM deficiency (HP:0002850)3.39424208
25Vasculitis (HP:0002633)3.39038460
26Stomatitis (HP:0010280)3.33925403
27Recurrent skin infections (HP:0001581)3.30993757
28Abnormality of T cells (HP:0002843)3.30703256
29Autoimmune thrombocytopenia (HP:0001973)3.30009931
30Recurrent bronchitis (HP:0002837)3.28739065
31Arterial thrombosis (HP:0004420)3.20122639
32Abnormality of T cell physiology (HP:0011840)3.19933209
33Abnormality of the nasal mucosa (HP:0000433)3.18933382
34Petechiae (HP:0000967)3.18875981
35IgA deficiency (HP:0002720)3.15952775
36Gastrointestinal infarctions (HP:0005244)3.11048609
37Interstitial pulmonary disease (HP:0006530)3.09506153
38Pulmonary infiltrates (HP:0002113)2.95667951
39Abnormality of macrophages (HP:0004311)2.95511465
40Cellulitis (HP:0100658)2.94961678
41Increased IgM level (HP:0003496)2.94828678
42Pustule (HP:0200039)2.92230062
43Inflammation of the large intestine (HP:0002037)2.89865757
44Systemic lupus erythematosus (HP:0002725)2.87748790
45Increased cerebral lipofuscin (HP:0011813)2.87308959
46Gastrointestinal inflammation (HP:0004386)2.87058249
47Hypertensive crisis (HP:0100735)2.82180983
48Meningitis (HP:0001287)2.81884587
49Gingival bleeding (HP:0000225)2.76120403
50Keratoconjunctivitis (HP:0001096)2.76073556
51Hemoptysis (HP:0002105)2.76015551
52Loss of speech (HP:0002371)2.75875570
53Chronic diarrhea (HP:0002028)2.73159124
54Dysostosis multiplex (HP:0000943)2.72923740
55Periodontitis (HP:0000704)2.72898020
56Recurrent gram-negative bacterial infections (HP:0005420)2.72243882
57Abnormality of the fingertips (HP:0001211)2.69757466
58Leukocytosis (HP:0001974)2.65693924
59Increased IgE level (HP:0003212)2.63804216
60Colitis (HP:0002583)2.63654799
61Eosinophilia (HP:0001880)2.62683338
62Epistaxis (HP:0000421)2.60536550
63Hypergammaglobulinemia (HP:0010702)2.60397237
64Prolonged bleeding time (HP:0003010)2.60377234
65Keratoconjunctivitis sicca (HP:0001097)2.60299626
66IgG deficiency (HP:0004315)2.58279029
67Purpura (HP:0000979)2.56242534
68Chest pain (HP:0100749)2.52555234
69Amaurosis fugax (HP:0100576)2.50828117
70Granulocytopenia (HP:0001913)2.50076454
71Polycythemia (HP:0001901)2.49780863
72Gastrointestinal stroma tumor (HP:0100723)2.49513481
73Gingivitis (HP:0000230)2.45183845
74Hepatosplenomegaly (HP:0001433)2.40200727
75Agammaglobulinemia (HP:0004432)2.39654419
76Abnormality of iron homeostasis (HP:0011031)2.38652485
77Fatigue (HP:0012378)2.38450998
78Acute myeloid leukemia (HP:0004808)2.37004455
79Abnormality of cells of the lymphoid lineage (HP:0012140)2.32703091
80Increased neuronal autofluorescent lipopigment (HP:0002074)2.32657274
81Gangrene (HP:0100758)2.32643221
82Spontaneous hematomas (HP:0007420)2.31791951
83Lymphopenia (HP:0001888)2.31006433
84Abnormality of eosinophils (HP:0001879)2.30096523
85Joint swelling (HP:0001386)2.26669050
86Encephalitis (HP:0002383)2.26464336
87Chronic obstructive pulmonary disease (HP:0006510)2.24197055
88Obstructive lung disease (HP:0006536)2.24197055
89Autoimmune hemolytic anemia (HP:0001890)2.23983689
90Pulmonary embolism (HP:0002204)2.23548674
91Severe combined immunodeficiency (HP:0004430)2.21440943
92Impaired platelet aggregation (HP:0003540)2.20246393
93Abnormal platelet function (HP:0011869)2.20246393
94Emphysema (HP:0002097)2.18494404
95B lymphocytopenia (HP:0010976)2.17062306
96Abnormality of B cell number (HP:0010975)2.17062306
97Basal ganglia calcification (HP:0002135)2.16822235
98Cholecystitis (HP:0001082)2.15684462
99Abnormal gallbladder physiology (HP:0012438)2.15684462
100Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.15604400
101Disinhibition (HP:0000734)2.13420131
102Vacuolated lymphocytes (HP:0001922)2.13297901
103Combined immunodeficiency (HP:0005387)2.13230894
104Slow saccadic eye movements (HP:0000514)2.12794924
105Anorexia (HP:0002039)2.11535353
106Myocardial infarction (HP:0001658)2.09608712
107Thyroiditis (HP:0100646)2.09469353
108Abnormality of the heme biosynthetic pathway (HP:0010472)2.09350881
109Abnormality of the pleura (HP:0002103)2.08646322
110Skin ulcer (HP:0200042)2.07580846
111Acne (HP:0001061)2.07478405
112Polyneuropathy (HP:0001271)2.06792826
113Lymphoma (HP:0002665)2.01520572
114Aplastic anemia (HP:0001915)2.01122606
115Chronic sinusitis (HP:0011109)2.01045718
116Increased serum ferritin (HP:0003281)1.99475414
117Osteomyelitis (HP:0002754)1.98139820
118Abnormal platelet volume (HP:0011876)1.96439996
119Hypoplasia of the thymus (HP:0000778)1.96053369
120Episodic fever (HP:0001954)1.95046225
121Vertigo (HP:0002321)1.94986645
122Glomerulopathy (HP:0100820)1.94907678
123Abnormality of transition element cation homeostasis (HP:0011030)1.94115816
124Albinism (HP:0001022)1.93140710
125Splenomegaly (HP:0001744)1.92600786
126Abnormal number of erythroid precursors (HP:0012131)1.89935705
127Abnormality of cells of the erythroid lineage (HP:0012130)1.89690405
128Urticaria (HP:0001025)1.89635515
129Osteolytic defects of the phalanges of the hand (HP:0009771)1.88643321
130Osteolytic defects of the hand bones (HP:0009699)1.88643321

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.10713092
2MAP3K143.75394497
3PRPF4B3.24481564
4* JAK33.08487945
5TXK2.89740760
6TYK22.86619597
7EEF2K2.78868416
8TBK12.77307099
9IKBKE2.56467096
10NME22.49887134
11IKBKB2.40201589
12ZAP702.25886090
13TAOK22.02592836
14KIT2.02528877
15CHUK1.95800236
16IRAK41.93146036
17JAK11.89172451
18ERN11.84325509
19FGFR41.82305167
20IRAK31.78849371
21TRIB31.76716670
22PIM21.69871241
23EPHB11.66933468
24TAOK31.66907764
25BMPR21.66481436
26BLK1.57785997
27TEC1.54897402
28EPHA31.51436843
29STK101.46415746
30NLK1.45197882
31PIM11.41766331
32* BTK1.41557102
33MAP2K31.41375498
34SIK11.39252903
35FGFR31.35743126
36* SYK1.34329176
37MAP3K101.32639592
38MAP3K131.32538834
39GRK71.28906512
40CSF1R1.27064655
41MST41.26233264
42RIPK41.24052405
43* LCK1.21555841
44LRRK21.21154005
45HCK1.19604545
46RPS6KA41.15154143
47FLT31.13718687
48ITK1.13608631
49PKN21.12706202
50FGR1.07247565
51RIPK11.04332608
52MAP3K110.99083965
53CSK0.98784760
54TGFBR10.97247909
55* JAK20.96858223
56PTK60.95051880
57SMG10.94492703
58KSR20.93359839
59ICK0.89445114
60SIK20.88360225
61TRPM70.83123020
62CDC42BPA0.81735246
63TGFBR20.81200678
64MOS0.79986323
65RPS6KB20.79373037
66MST1R0.73187918
67CDK40.71623357
68MAP3K30.71579577
69CDK120.71228112
70* LYN0.70802656
71TTN0.68460731
72MAP3K70.68215920
73MAPK110.67500345
74STK40.66518410
75MAP3K80.66475699
76MAPK120.66461093
77IRAK20.65849979
78MAP2K60.65591434
79NEK90.64186445
80MARK30.63984911
81TESK20.62558729
82MAPKAPK20.62462478
83DDR20.61640941
84SCYL20.61135287
85MAP3K50.60956443
86GRK60.58830793
87IRAK10.58086664
88SIK30.54632235
89MARK20.54356553
90PDPK10.52389720
91RAF10.52376744
92RPS6KA60.52352390
93MAP3K60.51084881
94PRKCQ0.50391347
95HIPK20.50211564
96CDK60.49527094
97BMX0.48981688
98RPS6KA10.48315565
99TAOK10.48271658
100MATK0.46629235
101PDK10.46011019
102CAMK1D0.45630961
103KDR0.45382908
104MAPKAPK30.45126192
105CLK10.44327334
106TNK20.44214285
107MAPK70.43440284
108ABL10.41167218
109RET0.40151641
110STK30.39681460
111NUAK10.38157572
112EIF2AK20.37811469
113MAP3K10.36895000
114EGFR0.36767599
115RPS6KB10.36164367
116PIK3CG0.35703609
117MAPK40.35591969
118RPS6KL10.35464120
119RPS6KC10.35464120
120RPS6KA50.35051881
121FES0.34208577
122CAMKK10.33890450
123FYN0.32772875
124* MAPK30.32096140
125ALK0.31355611
126PASK0.30039759
127TSSK60.28042706

Predicted pathways (KEGG)

RankGene SetZ-score
1NF-kappa B signaling pathway_Homo sapiens_hsa040643.08842766
2Allograft rejection_Homo sapiens_hsa053303.04425071
3Primary immunodeficiency_Homo sapiens_hsa053403.01028478
4Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.87953336
5Leishmaniasis_Homo sapiens_hsa051402.74622837
6Graft-versus-host disease_Homo sapiens_hsa053322.67623691
7* Measles_Homo sapiens_hsa051622.55774111
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.52822152
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.42015324
10RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.30954412
11Toll-like receptor signaling pathway_Homo sapiens_hsa046202.21188883
12Osteoclast differentiation_Homo sapiens_hsa043802.09332278
13NOD-like receptor signaling pathway_Homo sapiens_hsa046212.04515309
14Legionellosis_Homo sapiens_hsa051342.01896074
15Antigen processing and presentation_Homo sapiens_hsa046121.98452228
16Herpes simplex infection_Homo sapiens_hsa051681.90152417
17* Jak-STAT signaling pathway_Homo sapiens_hsa046301.87949302
18TNF signaling pathway_Homo sapiens_hsa046681.86289259
19Asthma_Homo sapiens_hsa053101.83626122
20Type I diabetes mellitus_Homo sapiens_hsa049401.82581317
21B cell receptor signaling pathway_Homo sapiens_hsa046621.82068647
22Influenza A_Homo sapiens_hsa051641.79182392
23Toxoplasmosis_Homo sapiens_hsa051451.75850202
24Autoimmune thyroid disease_Homo sapiens_hsa053201.71864047
25T cell receptor signaling pathway_Homo sapiens_hsa046601.69404568
26Hematopoietic cell lineage_Homo sapiens_hsa046401.67020869
27Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.46907260
28Malaria_Homo sapiens_hsa051441.44471115
29Pertussis_Homo sapiens_hsa051331.44442586
30* Acute myeloid leukemia_Homo sapiens_hsa052211.42161706
31Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.40081454
32Viral myocarditis_Homo sapiens_hsa054161.37008553
33Apoptosis_Homo sapiens_hsa042101.35045766
34Tuberculosis_Homo sapiens_hsa051521.29698253
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.27452066
36* Hepatitis B_Homo sapiens_hsa051611.27115072
37Staphylococcus aureus infection_Homo sapiens_hsa051501.25750229
38Shigellosis_Homo sapiens_hsa051311.18413870
39Chemokine signaling pathway_Homo sapiens_hsa040621.15051638
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.05340062
41* Chronic myeloid leukemia_Homo sapiens_hsa052201.04341195
42* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.04146411
43Transcriptional misregulation in cancer_Homo sapiens_hsa052021.04066349
44Hepatitis C_Homo sapiens_hsa051601.02216045
45Ribosome_Homo sapiens_hsa030101.01546350
46* Prolactin signaling pathway_Homo sapiens_hsa049171.00341209
47Small cell lung cancer_Homo sapiens_hsa052220.98629052
48Rheumatoid arthritis_Homo sapiens_hsa053230.98218381
49African trypanosomiasis_Homo sapiens_hsa051430.98086076
50Epstein-Barr virus infection_Homo sapiens_hsa051690.95858052
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.92979482
52Salmonella infection_Homo sapiens_hsa051320.92710001
53Leukocyte transendothelial migration_Homo sapiens_hsa046700.90288619
54DNA replication_Homo sapiens_hsa030300.89359079
55Adipocytokine signaling pathway_Homo sapiens_hsa049200.88260089
56Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.83695286
57Pancreatic cancer_Homo sapiens_hsa052120.80735914
58* Viral carcinogenesis_Homo sapiens_hsa052030.79494995
59* HTLV-I infection_Homo sapiens_hsa051660.79344418
60Other glycan degradation_Homo sapiens_hsa005110.70583284
61Prion diseases_Homo sapiens_hsa050200.68658605
62Platelet activation_Homo sapiens_hsa046110.68624432
63One carbon pool by folate_Homo sapiens_hsa006700.67152486
64Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.65365947
65Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64688259
66Insulin resistance_Homo sapiens_hsa049310.63259627
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62868431
68Type II diabetes mellitus_Homo sapiens_hsa049300.61673034
69Caffeine metabolism_Homo sapiens_hsa002320.61502787
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59974771
71Base excision repair_Homo sapiens_hsa034100.59197756
72HIF-1 signaling pathway_Homo sapiens_hsa040660.57828762
73p53 signaling pathway_Homo sapiens_hsa041150.57620651
74Amoebiasis_Homo sapiens_hsa051460.56787302
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.55594199
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52714448
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.52255188
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50954133
79Bladder cancer_Homo sapiens_hsa052190.50889432
80Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.49667642
81Renal cell carcinoma_Homo sapiens_hsa052110.48014183
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47843541
83Non-small cell lung cancer_Homo sapiens_hsa052230.44581523
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44228695
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43290481
86Notch signaling pathway_Homo sapiens_hsa043300.38908679
87Pentose phosphate pathway_Homo sapiens_hsa000300.38446701
88MicroRNAs in cancer_Homo sapiens_hsa052060.36175649
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35361699
90Non-homologous end-joining_Homo sapiens_hsa034500.34894143
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.33702153
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32433256
93Dorso-ventral axis formation_Homo sapiens_hsa043200.31776783
94Sulfur relay system_Homo sapiens_hsa041220.31535020
95Fructose and mannose metabolism_Homo sapiens_hsa000510.30881353
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.30690692
97FoxO signaling pathway_Homo sapiens_hsa040680.30490466
98ABC transporters_Homo sapiens_hsa020100.28413726
99MAPK signaling pathway_Homo sapiens_hsa040100.28135477
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.27246203
101Prostate cancer_Homo sapiens_hsa052150.24609736
102Insulin signaling pathway_Homo sapiens_hsa049100.24494819
103Endocytosis_Homo sapiens_hsa041440.24380994
104VEGF signaling pathway_Homo sapiens_hsa043700.24352309
105Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.23364325
106Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.23101385
107Mismatch repair_Homo sapiens_hsa034300.22779545
108mTOR signaling pathway_Homo sapiens_hsa041500.22077836
109Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.21897648
110GnRH signaling pathway_Homo sapiens_hsa049120.21414738
111RNA degradation_Homo sapiens_hsa030180.21085895
112Lysosome_Homo sapiens_hsa041420.20545915
113Glycosaminoglycan degradation_Homo sapiens_hsa005310.20382976
114Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.20109183
115Galactose metabolism_Homo sapiens_hsa000520.19773161
116Spliceosome_Homo sapiens_hsa030400.18573702
117Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.18194157
118Systemic lupus erythematosus_Homo sapiens_hsa053220.17324923
119Endometrial cancer_Homo sapiens_hsa052130.17246911
120Phagosome_Homo sapiens_hsa041450.17156106
121Homologous recombination_Homo sapiens_hsa034400.17142230
122Colorectal cancer_Homo sapiens_hsa052100.16526091
123* Pathways in cancer_Homo sapiens_hsa052000.15824816
124N-Glycan biosynthesis_Homo sapiens_hsa005100.15751112
125Proteoglycans in cancer_Homo sapiens_hsa052050.15587440

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