STAT3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.50834237
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.50834237
3antigen processing and presentation of endogenous antigen (GO:0019883)5.31674374
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.09321310
5negative regulation of cell killing (GO:0031342)4.09321310
6positive regulation of natural killer cell differentiation (GO:0032825)3.83004962
7* JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.72357898
8positive regulation of gamma-delta T cell activation (GO:0046645)3.57283512
9detection of other organism (GO:0098543)3.46837749
10positive regulation by symbiont of host defense response (GO:0052509)3.31580557
11modulation by symbiont of host defense response (GO:0052031)3.31580557
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.31580557
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.31580557
14positive regulation by organism of defense response of other organism involved in symbiotic interact3.31580557
15modulation by symbiont of host immune response (GO:0052553)3.31580557
16detection of bacterium (GO:0016045)3.28751331
17regulation of gamma-delta T cell differentiation (GO:0045586)3.27113330
18regulation of interleukin-12 biosynthetic process (GO:0045075)3.26628740
19germinal center formation (GO:0002467)3.26490878
20detection of molecule of bacterial origin (GO:0032490)3.20860146
21NIK/NF-kappaB signaling (GO:0038061)3.16885168
22macrophage activation involved in immune response (GO:0002281)3.14909433
23detection of external biotic stimulus (GO:0098581)3.14475824
24antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.12941611
25regulation of gamma-delta T cell activation (GO:0046643)3.06328535
26negative regulation of interleukin-12 production (GO:0032695)2.98220216
27response to type I interferon (GO:0034340)2.95870586
28cellular response to type I interferon (GO:0071357)2.87900848
29type I interferon signaling pathway (GO:0060337)2.87900848
30regulation of natural killer cell differentiation (GO:0032823)2.86089502
31antigen processing and presentation via MHC class Ib (GO:0002475)2.80076053
32hemidesmosome assembly (GO:0031581)2.77059282
33positive regulation of p38MAPK cascade (GO:1900745)2.76925447
34response to peptidoglycan (GO:0032494)2.75375962
35negative regulation of lymphocyte mediated immunity (GO:0002707)2.75261784
36detection of biotic stimulus (GO:0009595)2.74888094
37positive regulation of histone deacetylation (GO:0031065)2.73951845
38regulation of interferon-beta biosynthetic process (GO:0045357)2.70462548
39* growth hormone receptor signaling pathway (GO:0060396)2.69582611
40regulation of cholesterol homeostasis (GO:2000188)2.67353225
41cellular extravasation (GO:0045123)2.66447995
42positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.65353375
43positive thymic T cell selection (GO:0045059)2.64114175
44negative regulation of fatty acid transport (GO:2000192)2.63849395
45skin morphogenesis (GO:0043589)2.63118028
46valine metabolic process (GO:0006573)2.60721780
47positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.60143436
48cellular response to interleukin-15 (GO:0071350)2.58897654
49response to interleukin-15 (GO:0070672)2.57062067
50tolerance induction (GO:0002507)2.56142908
51negative regulation of leukocyte mediated immunity (GO:0002704)2.55636678
52regulation of tolerance induction (GO:0002643)2.55161434
53positive regulation of tolerance induction (GO:0002645)2.55002537
54positive regulation of cellular amide metabolic process (GO:0034250)2.54385341
55negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.52359445
56negative regulation of erythrocyte differentiation (GO:0045647)2.51787361
57low-density lipoprotein particle clearance (GO:0034383)2.51780289
58neutrophil activation involved in immune response (GO:0002283)2.50029579
59regulation of T-helper 2 cell differentiation (GO:0045628)2.49677214
60regulation of dendritic cell antigen processing and presentation (GO:0002604)2.47796699
61response to laminar fluid shear stress (GO:0034616)2.47370454
62regulation of response to interferon-gamma (GO:0060330)2.46988084
63regulation of type I interferon-mediated signaling pathway (GO:0060338)2.46294539
64response to host defenses (GO:0052200)2.46274488
65response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.46274488
66response to host (GO:0075136)2.46274488
67positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.46170549
68response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.45074319
69response to host immune response (GO:0052572)2.45074319
70negative regulation of T cell mediated immunity (GO:0002710)2.44690838
71negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.44664356
72regulation of cholesterol storage (GO:0010885)2.43777374
73production of molecular mediator involved in inflammatory response (GO:0002532)2.42780011
74* JAK-STAT cascade (GO:0007259)2.42263743
75lipopolysaccharide-mediated signaling pathway (GO:0031663)2.42030179
76regulation of T cell tolerance induction (GO:0002664)2.41548201
77positive regulation of T cell mediated cytotoxicity (GO:0001916)2.41187185
78peptidyl-glutamic acid carboxylation (GO:0017187)2.40834926
79protein carboxylation (GO:0018214)2.40834926
80regulation of B cell receptor signaling pathway (GO:0050855)2.40283449
81regulation of T cell mediated cytotoxicity (GO:0001914)2.40087238
82positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.38449127
83regulation of regulatory T cell differentiation (GO:0045589)2.38246815
84negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.37282928
85regulation of necroptotic process (GO:0060544)2.36576908
86response to muramyl dipeptide (GO:0032495)2.36565075
87Golgi transport vesicle coating (GO:0048200)2.34007946
88COPI coating of Golgi vesicle (GO:0048205)2.34007946
89regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.33923655
90interferon-gamma-mediated signaling pathway (GO:0060333)2.33905568
91regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.33027354
92negative regulation of innate immune response (GO:0045824)2.32965390
93thymic T cell selection (GO:0045061)2.32834111
94macrophage activation (GO:0042116)2.32726582
95regulation of T-helper 1 cell differentiation (GO:0045625)2.32556149
96negative thymic T cell selection (GO:0045060)2.32360248
97negative regulation of lipid storage (GO:0010888)2.32064112
98positive regulation of natural killer cell activation (GO:0032816)2.31807367
99negative regulation of humoral immune response (GO:0002921)2.31783838
100negative regulation of cytokine production involved in immune response (GO:0002719)2.31158275
101positive regulation of type 2 immune response (GO:0002830)2.30915177
102negative regulation of protein autophosphorylation (GO:0031953)2.30273552
103regulation of extracellular matrix disassembly (GO:0010715)2.29433195
104positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)2.28741914
105negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.28475911
106negative regulation of T-helper cell differentiation (GO:0045623)2.28475911
107negative regulation of complement activation (GO:0045916)2.27361975
108surfactant homeostasis (GO:0043129)2.26871860
109bundle of His cell to Purkinje myocyte communication (GO:0086069)2.26679835
110negative T cell selection (GO:0043383)2.26178536
111T-helper 1 type immune response (GO:0042088)2.25720737
112cell adhesion mediated by integrin (GO:0033627)2.25668095
113positive regulation of antigen processing and presentation (GO:0002579)2.24740410
114tyrosine phosphorylation of STAT protein (GO:0007260)2.22043883
115protein localization to endosome (GO:0036010)2.21668101
116establishment of endothelial barrier (GO:0061028)2.21357626
117positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.21160022
118regulation of type 2 immune response (GO:0002828)2.20490270
119positive regulation of interferon-alpha production (GO:0032727)2.20249912
120myeloid dendritic cell differentiation (GO:0043011)2.19980181
121* cellular response to growth hormone stimulus (GO:0071378)2.19873250
122positive regulation of cholesterol efflux (GO:0010875)2.19854477
123negative regulation of type 2 immune response (GO:0002829)2.19396602
124response to interferon-alpha (GO:0035455)2.17775343
125negative regulation of protein activation cascade (GO:2000258)2.17719511
126apoptotic cell clearance (GO:0043277)2.16240485
127mannose metabolic process (GO:0006013)2.15929140
128positive regulation of receptor recycling (GO:0001921)2.15701604
129regulation of antigen processing and presentation (GO:0002577)2.15452289
130positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.15392742
131defense response to protozoan (GO:0042832)2.14545595
132regulation of interferon-alpha production (GO:0032647)2.13792252
133positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.13246362
134cellular response to vitamin D (GO:0071305)2.12879757
135positive regulation of fatty acid beta-oxidation (GO:0032000)2.12811399
136positive regulation of humoral immune response (GO:0002922)2.11637833
137negative regulation of interleukin-6 production (GO:0032715)2.11559974
138negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.11495269
139dendritic cell chemotaxis (GO:0002407)2.11390736
140hepatocyte apoptotic process (GO:0097284)2.11044495
141positive regulation of interleukin-2 production (GO:0032743)2.10946435
142positive regulation of sterol transport (GO:0032373)2.10459904
143positive regulation of cholesterol transport (GO:0032376)2.10459904
144immunoglobulin mediated immune response (GO:0016064)2.09362013
145cytokine secretion (GO:0050663)2.08928339
146interleukin-1-mediated signaling pathway (GO:0070498)2.08205136
147regulation of membrane protein ectodomain proteolysis (GO:0051043)2.07514672
148positive regulation of B cell differentiation (GO:0045579)2.07147978
149gland morphogenesis (GO:0022612)2.06394675
150leukocyte aggregation (GO:0070486)2.06038692
151regulation of p38MAPK cascade (GO:1900744)2.05739494
152response to protozoan (GO:0001562)2.05446330
153positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.03975256
154negative regulation of bone resorption (GO:0045779)2.02199247
155regulation of natural killer cell activation (GO:0032814)2.01283019
156cellular response to vitamin (GO:0071295)2.00127214
157cellular response to interferon-alpha (GO:0035457)1.99843422
158adhesion of symbiont to host cell (GO:0044650)1.99602559
159virion attachment to host cell (GO:0019062)1.99602559
160regulation of interleukin-2 biosynthetic process (GO:0045076)1.98869540
161natural killer cell differentiation (GO:0001779)1.98489382
162T cell selection (GO:0045058)1.98387383
163regulation of natural killer cell mediated immunity (GO:0002715)1.98379839
164regulation of natural killer cell mediated cytotoxicity (GO:0042269)1.98379839
165vascular endothelial growth factor signaling pathway (GO:0038084)1.98336231

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.40404304
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.96649886
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.87763455
4* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.39055982
5* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.35731210
6* ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.87910286
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.80046951
8RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.58574574
9* RXR_22158963_ChIP-Seq_LIVER_Mouse2.40921448
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.40793739
11PPARA_22158963_ChIP-Seq_LIVER_Mouse2.30417196
12* EGR1_19374776_ChIP-ChIP_THP-1_Human2.25934842
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.25091194
14* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.23108515
15* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.17710475
16* STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.15625699
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.13270020
18IRF8_21731497_ChIP-ChIP_J774_Mouse2.13110828
19* CLOCK_20551151_ChIP-Seq_293T_Human2.13081492
20* LXR_22158963_ChIP-Seq_LIVER_Mouse2.12931514
21RARG_19884340_ChIP-ChIP_MEFs_Mouse2.12289280
22TRIM28_21343339_ChIP-Seq_HEK293_Human2.09805090
23* IRF8_27001747_Chip-Seq_BMDM_Mouse2.05814408
24RUNX_20019798_ChIP-Seq_JUKART_Human2.00540042
25IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.00482084
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.00135807
27MYB_21317192_ChIP-Seq_ERMYB_Mouse1.96647481
28* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.88077996
29MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.87010183
30TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.85072513
31ESR2_21235772_ChIP-Seq_MCF-7_Human1.81380832
32ESR1_21235772_ChIP-Seq_MCF-7_Human1.78999672
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.75698679
34MAF_26560356_Chip-Seq_TH1_Human1.73799318
35* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.71536426
36FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.71354655
37Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.71242550
38GATA1_22025678_ChIP-Seq_K562_Human1.70068335
39GATA2_21666600_ChIP-Seq_HMVEC_Human1.67249493
40FOXO3_23340844_ChIP-Seq_DLD1_Human1.65815515
41ELK3_25401928_ChIP-Seq_HUVEC_Human1.64346826
42* MYB_26560356_Chip-Seq_TH2_Human1.59980153
43BRD4_27068464_Chip-Seq_AML-cells_Mouse1.57533585
44TCF7_22412390_ChIP-Seq_EML_Mouse1.55677402
45SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.51080474
46CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.50546687
47NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.47174850
48KDM2B_26808549_Chip-Seq_SUP-B15_Human1.46478975
49KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.45548665
50FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.45004224
51VDR_21846776_ChIP-Seq_THP-1_Human1.42343106
52MYB_26560356_Chip-Seq_TH1_Human1.41136501
53MYC_22102868_ChIP-Seq_BL_Human1.40238482
54PPAR_26484153_Chip-Seq_NCI-H1993_Human1.39652820
55* LXR_22292898_ChIP-Seq_THP-1_Human1.38324730
56THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.37322117
57* GATA1_19941827_ChIP-Seq_MEL_Mouse1.37268831
58VDR_24763502_ChIP-Seq_THP-1_Human1.36242140
59TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35982744
60SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.33044487
61SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.33044487
62SCL_19346495_ChIP-Seq_HPC-7_Human1.30574442
63KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.30153267
64STAT6_21828071_ChIP-Seq_BEAS2B_Human1.28881378
65* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.28503378
66KDM2B_26808549_Chip-Seq_DND41_Human1.28209830
67KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.27762205
68HIF1A_21447827_ChIP-Seq_MCF-7_Human1.24558458
69TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.23581574
70UTX_26944678_Chip-Seq_JUKART_Human1.23529548
71RACK7_27058665_Chip-Seq_MCF-7_Human1.22608255
72* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.22131534
73SOX9_24532713_ChIP-Seq_HFSC_Mouse1.20804590
74E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.20740338
75* SPI1_23127762_ChIP-Seq_K562_Human1.18025506
76CJUN_26792858_Chip-Seq_BT549_Human1.17217127
77VDR_24787735_ChIP-Seq_THP-1_Human1.14362210
78SOX2_27498859_Chip-Seq_STOMACH_Mouse1.14110505
79ZNF263_19887448_ChIP-Seq_K562_Human1.13866950
80SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13296792
81SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.12904326
82TBX20_22080862_ChIP-Seq_HEART_Mouse1.12418506
83TBX20_22328084_ChIP-Seq_HEART_Mouse1.12418506
84* SOX2_20726797_ChIP-Seq_SW620_Human1.11113175
85* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.10631389
86KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10283191
87FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.09918814
88P63_26484246_Chip-Seq_KERATINOCYTES_Human1.09804824
89MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.09504295
90* RUNX1_22412390_ChIP-Seq_EML_Mouse1.09242068
91ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.08709044
92SPI1_23547873_ChIP-Seq_NB4_Human1.08478808
93CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08310416
94* PU_27001747_Chip-Seq_BMDM_Mouse1.08000306
95GATA3_27048872_Chip-Seq_THYMUS_Human1.07206506
96VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06124593
97JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05870387
98* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.04389809
99MAF_26560356_Chip-Seq_TH2_Human1.03995218
100UBF1/2_26484160_Chip-Seq_HMECs_Human1.03787847
101* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.03565264
102KDM2B_26808549_Chip-Seq_JURKAT_Human1.02739183
103* ATF3_27146783_Chip-Seq_COLON_Human1.02672474
104SMAD_19615063_ChIP-ChIP_OVARY_Human1.01772577
105* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.00651516
106GATA2_19941826_ChIP-Seq_K562_Human1.00298116
107* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.00000352
108GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99884706
109* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99258703
110GATA1_19941826_ChIP-Seq_K562_Human0.98575702
111* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.97444820
112PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96103139
113CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.95969364
114TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95655947
115NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.95647292
116P300_27058665_Chip-Seq_ZR-75-30cells_Human0.95342427

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat2.81540107
2MP0001835_abnormal_antigen_presentation2.45910251
3MP0003436_decreased_susceptibility_to2.39356648
4MP0000685_abnormal_immune_system2.39138713
5MP0003724_increased_susceptibility_to2.30925511
6MP0003303_peritoneal_inflammation2.27007181
7MP0003705_abnormal_hypodermis_morpholog2.25492771
8MP0002877_abnormal_melanocyte_morpholog2.25086846
9MP0008438_abnormal_cutaneous_collagen2.24349801
10MP0005451_abnormal_body_composition2.24017876
11* MP0003300_gastrointestinal_ulcer2.19327266
12MP0005387_immune_system_phenotype2.18122928
13MP0001790_abnormal_immune_system2.18122928
14MP0004510_myositis2.08013958
15MP0009785_altered_susceptibility_to1.97807553
16MP0005275_abnormal_skin_tensile1.97673733
17MP0002138_abnormal_hepatobiliary_system1.96073800
18MP0009840_abnormal_foam_cell1.87013061
19MP0003191_abnormal_cellular_cholesterol1.86796573
20MP0004947_skin_inflammation1.86782973
21MP0005000_abnormal_immune_tolerance1.76975398
22* MP0003566_abnormal_cell_adhesion1.72611529
23MP0001800_abnormal_humoral_immune1.71377086
24MP0002166_altered_tumor_susceptibility1.68645823
25MP0001533_abnormal_skeleton_physiology1.60295391
26* MP0005025_abnormal_response_to1.58884507
27* MP0002419_abnormal_innate_immunity1.54533904
28MP0005671_abnormal_response_to1.51727765
29MP0002148_abnormal_hypersensitivity_rea1.51715778
30* MP0002452_abnormal_antigen_presenting1.50453514
31MP0002933_joint_inflammation1.50378130
32MP0009278_abnormal_bone_marrow1.49652626
33* MP0002723_abnormal_immune_serum1.48185171
34MP0003279_aneurysm1.46462649
35* MP0010155_abnormal_intestine_physiology1.45409324
36* MP0005023_abnormal_wound_healing1.43447481
37MP0008260_abnormal_autophagy1.41029010
38* MP0003763_abnormal_thymus_physiology1.39885717
39MP0001853_heart_inflammation1.37997962
40MP0002405_respiratory_system_inflammati1.37716906
41MP0002060_abnormal_skin_morphology1.36994916
42MP0008004_abnormal_stomach_pH1.35980273
43MP0006082_CNS_inflammation1.35686060
44MP0005464_abnormal_platelet_physiology1.31799466
45* MP0003453_abnormal_keratinocyte_physiol1.31291974
46MP0001873_stomach_inflammation1.31096085
47MP0002006_tumorigenesis1.30155529
48MP0005076_abnormal_cell_differentiation1.29832389
49* MP0001819_abnormal_immune_cell1.29460983
50* MP0002420_abnormal_adaptive_immunity1.29188489
51MP0005164_abnormal_response_to1.28702303
52* MP0001845_abnormal_inflammatory_respons1.28316415
53MP0003172_abnormal_lysosome_physiology1.27231579
54MP0001958_emphysema1.26715278
55MP0001348_abnormal_lacrimal_gland1.25782281
56MP0003075_altered_response_to1.22926402
57MP0010234_abnormal_vibrissa_follicle1.21268955
58MP0003183_abnormal_peptide_metabolism1.20268605
59MP0002998_abnormal_bone_remodeling1.19947958
60MP0003828_pulmonary_edema1.17608922
61MP0001851_eye_inflammation1.16828627
62MP0005360_urolithiasis1.15312598
63MP0005058_abnormal_lysosome_morphology1.14509051
64MP0010368_abnormal_lymphatic_system1.14089857
65MP0003252_abnormal_bile_duct1.11975834
66MP0009764_decreased_sensitivity_to1.10814014
67MP0005166_decreased_susceptibility_to1.09829525
68* MP0003448_altered_tumor_morphology1.08157293
69* MP0008469_abnormal_protein_level1.07183080
70* MP0000609_abnormal_liver_physiology1.06831303
71MP0004883_abnormal_blood_vessel1.06694798
72* MP0003091_abnormal_cell_migration1.05678966
73MP0000343_altered_response_to1.04785798
74MP0001881_abnormal_mammary_gland1.04256353
75MP0005365_abnormal_bile_salt1.03498105
76MP0005409_darkened_coat_color1.01646456
77* MP0000716_abnormal_immune_system1.00538491
78MP0000604_amyloidosis0.99152493
79MP0002139_abnormal_hepatobiliary_system0.98878574
80MP0005310_abnormal_salivary_gland0.96693253
81MP0000767_abnormal_smooth_muscle0.95408878
82MP0005390_skeleton_phenotype0.95251515
83MP0004185_abnormal_adipocyte_glucose0.94067849
84MP0004858_abnormal_nervous_system0.93972201
85* MP0003045_fibrosis0.93948336
86MP0005083_abnormal_biliary_tract0.93298823
87* MP0002398_abnormal_bone_marrow0.92521282
88MP0006054_spinal_hemorrhage0.91519547
89MP0004264_abnormal_extraembryonic_tissu0.90082883
90* MP0010352_gastrointestinal_tract_polyps0.89639882
91* MP0001216_abnormal_epidermal_layer0.89424668
92MP0001545_abnormal_hematopoietic_system0.88598648
93MP0005397_hematopoietic_system_phenotyp0.88598648
94MP0004808_abnormal_hematopoietic_stem0.88399102
95MP0004381_abnormal_hair_follicle0.88016566
96MP0000689_abnormal_spleen_morphology0.87557263
97MP0002132_abnormal_respiratory_system0.86860138
98MP0002796_impaired_skin_barrier0.86820415
99MP0003656_abnormal_erythrocyte_physiolo0.86663911
100MP0000249_abnormal_blood_vessel0.86537543
101MP0009333_abnormal_splenocyte_physiolog0.86350130
102MP0004782_abnormal_surfactant_physiolog0.85557171
103MP0001243_abnormal_dermal_layer0.85540874
104* MP0000858_altered_metastatic_potential0.85301914
105MP0005666_abnormal_adipose_tissue0.85301431
106MP0003690_abnormal_glial_cell0.84134609
107MP0003329_amyloid_beta_deposits0.83371638
108MP0005375_adipose_tissue_phenotype0.82290407
109* MP0009643_abnormal_urine_homeostasis0.80255899
110MP0005085_abnormal_gallbladder_physiolo0.80208836
111MP0000733_abnormal_muscle_development0.80077259
112MP0008961_abnormal_basal_metabolism0.79381549
113MP0001879_abnormal_lymphatic_vessel0.79149931
114* MP0002429_abnormal_blood_cell0.78671388
115MP0000465_gastrointestinal_hemorrhage0.78553216
116MP0001849_ear_inflammation0.78338360
117MP0002396_abnormal_hematopoietic_system0.77405697
118* MP0009763_increased_sensitivity_to0.77390427
119* MP0002722_abnormal_immune_system0.76671969
120* MP0003795_abnormal_bone_structure0.76024743
121* MP0003866_abnormal_defecation0.75709831

Predicted human phenotypes

RankGene SetZ-score
1Myocardial infarction (HP:0001658)3.45470271
2Peritonitis (HP:0002586)3.03446206
3Keratoconjunctivitis sicca (HP:0001097)3.03278359
4Chronic otitis media (HP:0000389)2.93485499
5Myositis (HP:0100614)2.87435799
6Right ventricular cardiomyopathy (HP:0011663)2.84760705
7Premature rupture of membranes (HP:0001788)2.84479495
8Orchitis (HP:0100796)2.68984105
9Abnormality of the nasal mucosa (HP:0000433)2.66703426
10Protrusio acetabuli (HP:0003179)2.66401196
11* Eczematoid dermatitis (HP:0000976)2.62769545
12Gingival bleeding (HP:0000225)2.62637069
13Osteolytic defects of the hand bones (HP:0009699)2.60196729
14Osteolytic defects of the phalanges of the hand (HP:0009771)2.60196729
15Elevated erythrocyte sedimentation rate (HP:0003565)2.57300765
16Atrophic scars (HP:0001075)2.57261307
17Aortic aneurysm (HP:0004942)2.57037237
18Cerebral aneurysm (HP:0004944)2.55217840
19Nasal polyposis (HP:0100582)2.54919258
20Deep venous thrombosis (HP:0002625)2.53691762
21Spontaneous hematomas (HP:0007420)2.50172537
22* Recurrent fungal infections (HP:0002841)2.48773509
23Glomerulonephritis (HP:0000099)2.48412098
24Abnormality of the common coagulation pathway (HP:0010990)2.46523218
25Prolonged bleeding time (HP:0003010)2.45330995
26Xanthomatosis (HP:0000991)2.44849103
27Abnormal delayed hypersensitivity skin test (HP:0002963)2.42459169
28Esophageal varix (HP:0002040)2.38038295
29Broad metatarsal (HP:0001783)2.37420940
30Cervical subluxation (HP:0003308)2.37275268
31Stomatitis (HP:0010280)2.34986297
32Chronic mucocutaneous candidiasis (HP:0002728)2.34158659
33Recurrent cutaneous fungal infections (HP:0011370)2.34158659
34Arterial thrombosis (HP:0004420)2.29701091
35Aortic dissection (HP:0002647)2.28344039
36Hematochezia (HP:0002573)2.26460010
37Increased connective tissue (HP:0009025)2.25554268
38Mediastinal lymphadenopathy (HP:0100721)2.25458643
39Recurrent bacterial skin infections (HP:0005406)2.25174955
40Recurrent gram-negative bacterial infections (HP:0005420)2.20972121
41Purpura (HP:0000979)2.20468435
42* Gingivitis (HP:0000230)2.19671280
43Systemic lupus erythematosus (HP:0002725)2.19249789
44* Interstitial pulmonary disease (HP:0006530)2.16662983
45Hemorrhage of the eye (HP:0011885)2.16652730
46Meningitis (HP:0001287)2.16538269
47Thick nail (HP:0001805)2.15726162
48Recurrent viral infections (HP:0004429)2.15432194
49Segmental peripheral demyelination/remyelination (HP:0003481)2.14640717
50Mucopolysacchariduria (HP:0008155)2.14566391
51Urinary glycosaminoglycan excretion (HP:0003541)2.14566391
52Mitral stenosis (HP:0001718)2.14171438
53Hypoglycemic coma (HP:0001325)2.14027878
54Recurrent abscess formation (HP:0002722)2.13999387
55Malnutrition (HP:0004395)2.13662742
56Abnormality of liposaccharide metabolism (HP:0010968)2.13625591
57Abnormality of glycosphingolipid metabolism (HP:0004343)2.13625591
58Abnormality of glycolipid metabolism (HP:0010969)2.13625591
59Recurrent skin infections (HP:0001581)2.12483839
60Abnormality of macrophages (HP:0004311)2.12225786
61Acne (HP:0001061)2.11086073
62Complement deficiency (HP:0004431)2.10012669
63Emphysema (HP:0002097)2.08627160
64Gangrene (HP:0100758)2.07905552
65Vasculitis (HP:0002633)2.07201287
66Vertebral compression fractures (HP:0002953)2.07001950
67* Increased IgE level (HP:0003212)2.06391119
68Pulmonary infiltrates (HP:0002113)2.05098875
69Autoimmune thrombocytopenia (HP:0001973)2.05015709
70Vascular tortuosity (HP:0004948)2.04974887
71Gastrointestinal infarctions (HP:0005244)2.04292026
72Hyporeflexia of lower limbs (HP:0002600)2.03832622
73Increased variability in muscle fiber diameter (HP:0003557)2.03547926
74Periodontitis (HP:0000704)2.03378532
75Milia (HP:0001056)2.02477879
76Recurrent bronchitis (HP:0002837)2.02409079
77Loss of speech (HP:0002371)2.02165271
78Arterial tortuosity (HP:0005116)2.00544490
79Asymmetric septal hypertrophy (HP:0001670)2.00175209
80Polycythemia (HP:0001901)1.99440147
81Encephalitis (HP:0002383)1.98486839
82Pustule (HP:0200039)1.97974566
83Inflammation of the large intestine (HP:0002037)1.96920244
84Colitis (HP:0002583)1.96642612
85Abnormality of mucopolysaccharide metabolism (HP:0011020)1.95816284
86Abnormality of polysaccharide metabolism (HP:0011012)1.95816284
87Abnormality of glycosaminoglycan metabolism (HP:0004371)1.95816284
88Abnormality of complement system (HP:0005339)1.95343068
89Vacuolated lymphocytes (HP:0001922)1.94917833
90Abnormality of the peritoneum (HP:0002585)1.93935728
91Gastrointestinal stroma tumor (HP:0100723)1.93494669
92Dilatation of the ascending aorta (HP:0005111)1.92714379
93Retrobulbar optic neuritis (HP:0100654)1.92673741
94Optic neuritis (HP:0100653)1.92673741
95Abnormality of skeletal muscle fiber size (HP:0012084)1.92529247
96Mitral valve prolapse (HP:0001634)1.91738422
97Chest pain (HP:0100749)1.91041937
98Abnormality of proline metabolism (HP:0010907)1.89786948
99Hydroxyprolinuria (HP:0003080)1.89786948
100Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.89609940
101Thin bony cortex (HP:0002753)1.89167292
102Abnormality of the endocardium (HP:0004306)1.87543792
103Hemoptysis (HP:0002105)1.86955325
104* Aneurysm (HP:0002617)1.85745259
105Gastrointestinal inflammation (HP:0004386)1.84307705
106Abnormality of the pericardium (HP:0001697)1.83734577
107Dysostosis multiplex (HP:0000943)1.83396816
108Pulmonary embolism (HP:0002204)1.83185810
109Tetraparesis (HP:0002273)1.81927977
110Distal lower limb muscle weakness (HP:0009053)1.81926693
111Chronic obstructive pulmonary disease (HP:0006510)1.81134116
112Obstructive lung disease (HP:0006536)1.81134116
113Muscle fiber splitting (HP:0003555)1.80585395
114Abnormality of the pleura (HP:0002103)1.80551143
115Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.80545082
116Joint swelling (HP:0001386)1.80034618
117Petechiae (HP:0000967)1.79295982
118Shallow orbits (HP:0000586)1.78059127
119Epistaxis (HP:0000421)1.77288238
120Abnormality of monocarboxylic acid metabolism (HP:0010996)1.73005610
121Ectopia lentis (HP:0001083)1.72575459
122Keratoconjunctivitis (HP:0001096)1.72419252
123Increased cerebral lipofuscin (HP:0011813)1.71938166
124Hypoalphalipoproteinemia (HP:0003233)1.71722891
125Joint hemorrhage (HP:0005261)1.71418427
126Menorrhagia (HP:0000132)1.69364321
127Abnormality of T cell number (HP:0011839)1.69085763
128Abnormality of T cell physiology (HP:0011840)1.68648473
129Ankle contracture (HP:0006466)1.68551132
130Fragile skin (HP:0001030)1.67166726
131Nephritis (HP:0000123)1.65951022
132Hyperglycemia (HP:0003074)1.64411975
133Amyloidosis (HP:0011034)1.64220041
134* Skin ulcer (HP:0200042)1.62929252
135Ventricular tachycardia (HP:0004756)1.62563938
136T lymphocytopenia (HP:0005403)1.61644146

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.73969112
2TRIB33.23562434
3JAK32.88164224
4TYK22.70661217
5PRPF4B2.70554938
6MAP4K12.64452643
7RIPK42.57773244
8MAP3K142.50609716
9SIK12.26466387
10TBK12.22145123
11* FGFR41.94107567
12* JAK11.87073939
13TAOK31.85556778
14PKN21.85168658
15IRAK31.81696837
16PTK61.81603652
17TTN1.79092305
18ZAP701.77650816
19TGFBR21.74578701
20IKBKE1.73163376
21TXK1.65927959
22RIPK11.52900942
23CHUK1.52663064
24STK101.51438363
25IKBKB1.49285129
26MAP3K31.47681474
27FLT31.46722501
28CDC42BPA1.46269347
29FES1.45865951
30INSRR1.45066109
31BLK1.42620294
32EEF2K1.39678078
33LRRK21.39346407
34ITK1.37301804
35CSK1.35309881
36NEK91.26334765
37KIT1.26205074
38MAPK151.24254572
39KSR21.23527637
40EPHA21.17199595
41SMG11.16543608
42* EPHB11.15834704
43BTK1.15709021
44MST1R1.13541537
45IRAK41.13065881
46TAOK11.12423882
47MAP3K61.12293065
48PDGFRA1.09860005
49TRPM71.09368286
50* JAK21.05237394
51* MAP3K11.03383033
52PIM21.03101088
53MARK21.01623469
54MAP3K21.00552823
55LATS10.96976392
56PDGFRB0.95909873
57SIK30.95780082
58TEC0.94761557
59MAPKAPK30.93591050
60BMX0.93530685
61PTK20.92543403
62TAOK20.91561453
63RPS6KA40.88826156
64MAP2K30.88041869
65ICK0.88032851
66LCK0.87586058
67DMPK0.86248530
68PDPK10.85472831
69* FGFR30.84880150
70MYLK0.84209300
71MST40.83528915
72MAPK70.83379394
73* HCK0.83053978
74MAP3K100.80760996
75SGK30.80726075
76PRKD20.80623356
77MATK0.78870493
78TGFBR10.76084665
79MET0.74952729
80MAPK110.74670878
81CSF1R0.74212193
82FGR0.74059468
83CAMK1D0.73776709
84GSK3A0.73359072
85LYN0.72887334
86PIK3CG0.72845757
87MAP3K70.71318447
88MAP3K130.71031710
89PDK10.70923304
90MAP2K20.70330468
91MAP3K110.70118594
92PIM10.69743151
93CDK60.69178068
94MAPK120.69026877
95STK30.68370482
96BMPR20.68326996
97YES10.67981321
98KDR0.67644074
99MARK30.67624588
100CDK120.66716821
101SYK0.64659163
102TIE10.63098084
103CLK10.62370859
104MAP2K60.59542340
105TNK20.56244233
106* MTOR0.56002685
107PRKCH0.55686250
108RPS6KA20.55533921
109DYRK1B0.54417673
110STK240.53167946
111RPS6KB20.53012603
112PRKD10.52830995
113SGK20.51050338
114PRKAA20.50696799
115IGF1R0.50381906
116STK380.48122508
117PAK20.48112103
118FRK0.47638481
119* HIPK20.47212196
120SIK20.46066577
121CDK90.45773036
122ABL10.45614758
123EGFR0.45607209
124GRK60.45392228
125FYN0.45248837
126RPS6KL10.43934157
127RPS6KC10.43934157
128PIK3CA0.43762012
129MAPK40.43637800
130* MAPKAPK20.43115303
131PRKG20.42164119
132PRKCQ0.41374648
133INSR0.36975906
134DDR20.36533877
135BCKDK0.34052819
136* RET0.34010503
137LMTK20.33682085

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.11476621
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.10279556
3Staphylococcus aureus infection_Homo sapiens_hsa051502.07133011
4Osteoclast differentiation_Homo sapiens_hsa043801.95031648
5Caffeine metabolism_Homo sapiens_hsa002321.93759762
6* Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.92145080
7* Toxoplasmosis_Homo sapiens_hsa051451.71516066
8TNF signaling pathway_Homo sapiens_hsa046681.61227701
9* Measles_Homo sapiens_hsa051621.60269697
10* Jak-STAT signaling pathway_Homo sapiens_hsa046301.60159039
11Primary immunodeficiency_Homo sapiens_hsa053401.56917012
12Complement and coagulation cascades_Homo sapiens_hsa046101.55292771
13Intestinal immune network for IgA production_Homo sapiens_hsa046721.54193582
14Malaria_Homo sapiens_hsa051441.52959780
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.52684403
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.51107157
17Antigen processing and presentation_Homo sapiens_hsa046121.49522179
18Viral myocarditis_Homo sapiens_hsa054161.32211999
19B cell receptor signaling pathway_Homo sapiens_hsa046621.32001938
20Pertussis_Homo sapiens_hsa051331.29096507
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.28889481
22Legionellosis_Homo sapiens_hsa051341.27539078
23Chronic myeloid leukemia_Homo sapiens_hsa052201.23111946
24* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.20795371
25Influenza A_Homo sapiens_hsa051641.19272958
26Leukocyte transendothelial migration_Homo sapiens_hsa046701.18941097
27* Insulin resistance_Homo sapiens_hsa049311.18788299
28* Acute myeloid leukemia_Homo sapiens_hsa052211.18353754
29Amoebiasis_Homo sapiens_hsa051461.15731580
30Apoptosis_Homo sapiens_hsa042101.13886312
31ECM-receptor interaction_Homo sapiens_hsa045121.13592913
32T cell receptor signaling pathway_Homo sapiens_hsa046601.13537072
33NOD-like receptor signaling pathway_Homo sapiens_hsa046211.13278890
34Type I diabetes mellitus_Homo sapiens_hsa049401.13013470
35* Prolactin signaling pathway_Homo sapiens_hsa049171.09108722
36Glycosaminoglycan degradation_Homo sapiens_hsa005311.08948735
37Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.07966325
38Hematopoietic cell lineage_Homo sapiens_hsa046401.07815026
39Focal adhesion_Homo sapiens_hsa045101.06797592
40Graft-versus-host disease_Homo sapiens_hsa053321.05694419
41Small cell lung cancer_Homo sapiens_hsa052221.05643634
42Lysosome_Homo sapiens_hsa041421.04257730
43Tuberculosis_Homo sapiens_hsa051521.03177716
44* Adipocytokine signaling pathway_Homo sapiens_hsa049201.02670073
45Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.00350157
46Fatty acid degradation_Homo sapiens_hsa000711.00012028
47* Hepatitis C_Homo sapiens_hsa051601.00005074
48ABC transporters_Homo sapiens_hsa020100.99379912
49Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.98201458
50Tryptophan metabolism_Homo sapiens_hsa003800.97644983
51Maturity onset diabetes of the young_Homo sapiens_hsa049500.97531276
52Primary bile acid biosynthesis_Homo sapiens_hsa001200.96108655
53Allograft rejection_Homo sapiens_hsa053300.95145271
54PPAR signaling pathway_Homo sapiens_hsa033200.92690681
55Adherens junction_Homo sapiens_hsa045200.91705482
56Phagosome_Homo sapiens_hsa041450.87678032
57Herpes simplex infection_Homo sapiens_hsa051680.87602877
58Histidine metabolism_Homo sapiens_hsa003400.87557751
59Non-small cell lung cancer_Homo sapiens_hsa052230.86823443
60Shigellosis_Homo sapiens_hsa051310.86784008
61* Pancreatic cancer_Homo sapiens_hsa052120.85808320
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.83886301
63* Hepatitis B_Homo sapiens_hsa051610.80931432
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.79203032
65* Chemokine signaling pathway_Homo sapiens_hsa040620.78466350
66Platelet activation_Homo sapiens_hsa046110.77568121
67Starch and sucrose metabolism_Homo sapiens_hsa005000.76165072
68* Proteoglycans in cancer_Homo sapiens_hsa052050.76157028
69Salmonella infection_Homo sapiens_hsa051320.75906562
70Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.74421768
71Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73390842
72Nitrogen metabolism_Homo sapiens_hsa009100.71302343
73Arginine biosynthesis_Homo sapiens_hsa002200.70976665
74Other glycan degradation_Homo sapiens_hsa005110.70155308
75Asthma_Homo sapiens_hsa053100.69387275
76Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.68474742
77Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.68189586
78GnRH signaling pathway_Homo sapiens_hsa049120.66616909
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65892270
80Galactose metabolism_Homo sapiens_hsa000520.65779030
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.64934269
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.64427127
83Endometrial cancer_Homo sapiens_hsa052130.64184759
84Insulin signaling pathway_Homo sapiens_hsa049100.63618908
85Dorso-ventral axis formation_Homo sapiens_hsa043200.62845814
86Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.62396692
87Phenylalanine metabolism_Homo sapiens_hsa003600.61681877
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.60905984
89mTOR signaling pathway_Homo sapiens_hsa041500.60801291
90Prion diseases_Homo sapiens_hsa050200.60418229
91Bladder cancer_Homo sapiens_hsa052190.60037454
92Rheumatoid arthritis_Homo sapiens_hsa053230.59307638
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59253118
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.58003982
95Choline metabolism in cancer_Homo sapiens_hsa052310.57431518
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56090968
97Prostate cancer_Homo sapiens_hsa052150.55965038
98Endocytosis_Homo sapiens_hsa041440.55812720
99* FoxO signaling pathway_Homo sapiens_hsa040680.55295408
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54925886
101Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54741934
102Autoimmune thyroid disease_Homo sapiens_hsa053200.54602395
103Lysine degradation_Homo sapiens_hsa003100.53921857
104Fatty acid metabolism_Homo sapiens_hsa012120.53649699
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.52360620
106Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52356528
107* HIF-1 signaling pathway_Homo sapiens_hsa040660.50971107
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50655496
109Fructose and mannose metabolism_Homo sapiens_hsa000510.50649303
110Notch signaling pathway_Homo sapiens_hsa043300.50505516
111HTLV-I infection_Homo sapiens_hsa051660.50469688
112Renal cell carcinoma_Homo sapiens_hsa052110.49909139
113Fat digestion and absorption_Homo sapiens_hsa049750.49400903
114Type II diabetes mellitus_Homo sapiens_hsa049300.49381087
115Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49323804
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48181461
117African trypanosomiasis_Homo sapiens_hsa051430.48124622
118Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47382312
119PI3K-Akt signaling pathway_Homo sapiens_hsa041510.47202596
120VEGF signaling pathway_Homo sapiens_hsa043700.47077184
121Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45234246
122Renin-angiotensin system_Homo sapiens_hsa046140.44647822
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44313236
124Inositol phosphate metabolism_Homo sapiens_hsa005620.42726391

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