STAT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)8.35232538
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)8.35232538
3antigen processing and presentation of endogenous antigen (GO:0019883)7.73804585
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.13597607
5positive regulation of gamma-delta T cell activation (GO:0046645)6.06111003
6positive regulation of type I interferon-mediated signaling pathway (GO:0060340)5.56457849
7* response to type I interferon (GO:0034340)5.38602174
8negative thymic T cell selection (GO:0045060)5.37157228
9positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.34405861
10* type I interferon signaling pathway (GO:0060337)5.33125184
11* cellular response to type I interferon (GO:0071357)5.33125184
12negative T cell selection (GO:0043383)5.30775278
13positive thymic T cell selection (GO:0045059)4.70218734
14positive regulation of interferon-alpha production (GO:0032727)4.61048421
15regulation of gamma-delta T cell differentiation (GO:0045586)4.52654062
16regulation of B cell receptor signaling pathway (GO:0050855)4.44619476
17T cell migration (GO:0072678)4.42105071
18regulation of interferon-alpha production (GO:0032647)4.41444111
19thymic T cell selection (GO:0045061)4.40076761
20regulation of T cell tolerance induction (GO:0002664)4.36539658
21regulation of gamma-delta T cell activation (GO:0046643)4.33400394
22regulation of interleukin-12 biosynthetic process (GO:0045075)4.24189580
23negative regulation of cell killing (GO:0031342)4.24092170
24negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.24092170
25response to interleukin-15 (GO:0070672)4.22229257
26T cell selection (GO:0045058)4.10632781
27positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.10222759
28leukocyte aggregation (GO:0070486)4.09422360
29response to interferon-alpha (GO:0035455)4.06757933
30interferon-gamma production (GO:0032609)4.04981776
31* interferon-gamma-mediated signaling pathway (GO:0060333)3.98715541
32antigen processing and presentation via MHC class Ib (GO:0002475)3.97776843
33* regulation of type I interferon-mediated signaling pathway (GO:0060338)3.95982794
34cellular response to interleukin-15 (GO:0071350)3.92961115
35positive T cell selection (GO:0043368)3.89846632
36negative regulation of T cell mediated immunity (GO:0002710)3.85466940
37regulation of alpha-beta T cell proliferation (GO:0046640)3.85415533
38regulation of MHC class I biosynthetic process (GO:0045343)3.85045942
39NIK/NF-kappaB signaling (GO:0038061)3.83655304
40immunoglobulin mediated immune response (GO:0016064)3.81212930
41cellular response to interferon-alpha (GO:0035457)3.78733588
42regulation of isotype switching to IgG isotypes (GO:0048302)3.72833419
43regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.69486510
44regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.68485406
45detection of other organism (GO:0098543)3.61020481
46* defense response to virus (GO:0051607)3.59108579
47regulation of interferon-beta biosynthetic process (GO:0045357)3.57658260
48regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.54110429
49T cell costimulation (GO:0031295)3.52562957
50positive regulation of humoral immune response (GO:0002922)3.51567013
51macrophage activation involved in immune response (GO:0002281)3.51296935
52positive regulation of antigen processing and presentation (GO:0002579)3.50687075
53detection of bacterium (GO:0016045)3.50132756
54lymphocyte costimulation (GO:0031294)3.46550034
55negative regulation of interleukin-12 production (GO:0032695)3.46224551
56lymphocyte chemotaxis (GO:0048247)3.45255789
57positive regulation of type 2 immune response (GO:0002830)3.42124299
58regulation of viral genome replication (GO:0045069)3.39987962
59response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.37911202
60response to host immune response (GO:0052572)3.37911202
61regulation of tolerance induction (GO:0002643)3.36321020
62regulation of RIG-I signaling pathway (GO:0039535)3.35993075
63* response to interferon-beta (GO:0035456)3.35052599
64positive regulation of tolerance induction (GO:0002645)3.33850793
65modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.30189159
66positive regulation by organism of defense response of other organism involved in symbiotic interact3.30189159
67modulation by symbiont of host immune response (GO:0052553)3.30189159
68positive regulation by symbiont of host defense response (GO:0052509)3.30189159
69modulation by symbiont of host defense response (GO:0052031)3.30189159
70modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.30189159
71* regulation of response to interferon-gamma (GO:0060330)3.29504098
72response to host defenses (GO:0052200)3.29122688
73response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.29122688
74response to host (GO:0075136)3.29122688
75positive regulation of natural killer cell differentiation (GO:0032825)3.27308089
76positive regulation of alpha-beta T cell proliferation (GO:0046641)3.26770658
77positive regulation of interferon-beta production (GO:0032728)3.26743146
78response to peptidoglycan (GO:0032494)3.25941695
79regulation of T cell receptor signaling pathway (GO:0050856)3.24556471
80T cell receptor signaling pathway (GO:0050852)3.23978665
81regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.23092341
82positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.23092341
83tolerance induction (GO:0002507)3.22678038
84cellular response to virus (GO:0098586)3.22028488
85regulation of antigen processing and presentation (GO:0002577)3.21958434
86cellular response to zinc ion (GO:0071294)3.21174140
87regulation of type 2 immune response (GO:0002828)3.18034546
88negative regulation of viral process (GO:0048525)3.17005438
89* response to interferon-gamma (GO:0034341)3.16274421
90detection of external biotic stimulus (GO:0098581)3.15043947
91regulation of B cell differentiation (GO:0045577)3.14254624
92negative regulation of lymphocyte mediated immunity (GO:0002707)3.12937006
93B cell mediated immunity (GO:0019724)3.12780172
94antigen receptor-mediated signaling pathway (GO:0050851)3.12343469
95natural killer cell activation involved in immune response (GO:0002323)3.10175509
96positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.09941574
97positive regulation of interleukin-2 production (GO:0032743)3.09494708
98* JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.09383831
99* cellular response to interferon-gamma (GO:0071346)3.08578126
100regulation of T-helper 1 cell differentiation (GO:0045625)3.08255852
101detection of molecule of bacterial origin (GO:0032490)3.08155245
102negative regulation of type 2 immune response (GO:0002829)3.07169674
103myeloid dendritic cell activation (GO:0001773)3.06259889
104B cell receptor signaling pathway (GO:0050853)3.03412946
105regulation of interleukin-2 biosynthetic process (GO:0045076)3.02872625
106positive regulation of B cell differentiation (GO:0045579)3.02083535
107B cell proliferation (GO:0042100)3.01983328
108* regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.99958615
109negative regulation of viral genome replication (GO:0045071)2.98247861
110cellular response to exogenous dsRNA (GO:0071360)2.95689845
111myeloid dendritic cell differentiation (GO:0043011)2.95242438
112leukocyte cell-cell adhesion (GO:0007159)2.94886995
113positive regulation of cytokine-mediated signaling pathway (GO:0001961)2.91949437
114natural killer cell activation (GO:0030101)2.90138348
115regulation of dendritic cell antigen processing and presentation (GO:0002604)2.88009808
116CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.87625703
117positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.86809156
118germinal center formation (GO:0002467)2.84177474
119negative regulation of leukocyte mediated immunity (GO:0002704)2.83318849
120mast cell activation (GO:0045576)2.81344443
121negative regulation of innate immune response (GO:0045824)2.80939683
122Arp2/3 complex-mediated actin nucleation (GO:0034314)2.80345256
123defense response to protozoan (GO:0042832)2.79942677
124lymphocyte migration (GO:0072676)2.77814298
125respiratory burst (GO:0045730)2.76474107
126positive regulation of response to cytokine stimulus (GO:0060760)2.74817614
127positive regulation of immunoglobulin mediated immune response (GO:0002891)2.74699773
128positive regulation of B cell mediated immunity (GO:0002714)2.74699773
129response to protozoan (GO:0001562)2.73981325
130regulation of T cell mediated cytotoxicity (GO:0001914)2.73481816
131cellular extravasation (GO:0045123)2.72789091
132regulation of interferon-beta production (GO:0032648)2.72486502
133natural killer cell differentiation (GO:0001779)2.72078791
134regulation of regulatory T cell differentiation (GO:0045589)2.71367088
135positive regulation of interleukin-12 production (GO:0032735)2.71271313
136regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.71085639
137regulation of natural killer cell mediated immunity (GO:0002715)2.71085639

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.25450141
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.39796675
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.63154738
4IRF8_21731497_ChIP-ChIP_J774_Mouse5.12499858
5* IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.93399811
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.73112401
7* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.39116569
8* STAT4_19710469_ChIP-ChIP_TH1__Mouse3.29048987
9IRF8_27001747_Chip-Seq_BMDM_Mouse3.19137188
10* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.12208383
11* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.83519642
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.80944964
13* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.75621299
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.73277715
15RUNX_20019798_ChIP-Seq_JUKART_Human2.71403330
16* MYB_26560356_Chip-Seq_TH2_Human2.59232494
17* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.56326299
18* MAF_26560356_Chip-Seq_TH1_Human2.49661170
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.32968010
20* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.31671856
21* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.28832212
22MYB_26560356_Chip-Seq_TH1_Human2.25603743
23* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.16318574
24MYC_22102868_ChIP-Seq_BL_Human2.07666550
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.01056797
26UTX_26944678_Chip-Seq_JUKART_Human2.00145086
27VDR_21846776_ChIP-Seq_THP-1_Human1.92677764
28SPI1_23547873_ChIP-Seq_NB4_Human1.90384822
29* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.81040742
30SCL_19346495_ChIP-Seq_HPC-7_Human1.80748951
31GATA1_22025678_ChIP-Seq_K562_Human1.75861015
32* RUNX1_22412390_ChIP-Seq_EML_Mouse1.75848268
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.74761405
34NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.74592660
35* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.69620148
36VDR_24763502_ChIP-Seq_THP-1_Human1.67183224
37* GATA3_27048872_Chip-Seq_THYMUS_Human1.67150830
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.65423086
39* MAF_26560356_Chip-Seq_TH2_Human1.59099782
40Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.54455912
41* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.53325935
42SPI1_23127762_ChIP-Seq_K562_Human1.52327581
43ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.51836783
44* PU_27001747_Chip-Seq_BMDM_Mouse1.50124204
45FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.43739551
46TCF7_22412390_ChIP-Seq_EML_Mouse1.42182058
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.39278928
48MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.38249832
49* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.37357254
50CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32141537
51NOTCH1_21737748_ChIP-Seq_TLL_Human1.30935738
52PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29628508
53GATA2_22383799_ChIP-Seq_G1ME_Mouse1.28784406
54CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27914736
55* GATA3_26560356_Chip-Seq_TH2_Human1.26065419
56THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.21310931
57SMAD_19615063_ChIP-ChIP_OVARY_Human1.18114427
58LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.14451736
59* KDM2B_26808549_Chip-Seq_DND41_Human1.14417373
60EGR1_23403033_ChIP-Seq_LIVER_Mouse1.10528665
61* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.10169885
62TP63_17297297_ChIP-ChIP_HaCaT_Human1.08830362
63* ELK3_25401928_ChIP-Seq_HUVEC_Human1.08584763
64ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.07915291
65CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04649018
66E2F7_22180533_ChIP-Seq_HELA_Human1.04131368
67KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02921668
68CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.02772843
69ELF1_17652178_ChIP-ChIP_JURKAT_Human1.01628263
70* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.01589328
71TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.00546258
72* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99285210
73GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97798890
74GATA2_21666600_ChIP-Seq_HMVEC_Human0.96355574
75GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.95733940
76ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95411263
77GATA1_19941827_ChIP-Seq_MEL_Mouse0.94926058
78CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94758566
79LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.94343744
80TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.93760466
81* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.92723143
82EGR1_19032775_ChIP-ChIP_M12_Human0.92612959
83RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.91063206
84PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89602348
85PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.88876280
86VDR_24787735_ChIP-Seq_THP-1_Human0.88481589
87TFEB_21752829_ChIP-Seq_HELA_Human0.86853580
88BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.86116808
89* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85621820
90SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.85539619
91SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.85539619
92RXR_22158963_ChIP-Seq_LIVER_Mouse0.85526415
93* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85400769
94* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.83153628
95* LXR_22292898_ChIP-Seq_THP-1_Human0.83126618
96* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.82420458
97RARG_19884340_ChIP-ChIP_MEFs_Mouse0.81670032
98* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80828050
99CLOCK_20551151_ChIP-Seq_293T_Human0.78342369
100* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.76515334
101KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.76429923
102* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.74656500
103* KDM2B_26808549_Chip-Seq_JURKAT_Human0.74285599
104GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73713481
105SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.73077882
106CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.71990653
107LXR_22158963_ChIP-Seq_LIVER_Mouse0.71676833
108SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.70783108
109ERG_20887958_ChIP-Seq_HPC-7_Mouse0.70092256
110SOX2_20726797_ChIP-Seq_SW620_Human0.69586712
111GATA2_19941826_ChIP-Seq_K562_Human0.69074969
112* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.69058318
113GATA1_19941826_ChIP-Seq_K562_Human0.66622502
114KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.64095984
115GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.63519831
116FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.62548835

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0001835_abnormal_antigen_presentation4.51815010
2MP0005671_abnormal_response_to3.71524462
3MP0000685_abnormal_immune_system3.70121515
4MP0009785_altered_susceptibility_to3.50699969
5MP0003763_abnormal_thymus_physiology3.31149734
6MP0001790_abnormal_immune_system3.28921999
7MP0005387_immune_system_phenotype3.28921999
8* MP0001800_abnormal_humoral_immune3.04729740
9MP0005000_abnormal_immune_tolerance2.91989032
10* MP0005025_abnormal_response_to2.88435225
11MP0003436_decreased_susceptibility_to2.88424447
12MP0006082_CNS_inflammation2.79391314
13MP0003724_increased_susceptibility_to2.78943065
14* MP0002723_abnormal_immune_serum2.71223366
15* MP0002452_abnormal_antigen_presenting2.69891685
16* MP0001819_abnormal_immune_cell2.55766788
17* MP0002420_abnormal_adaptive_immunity2.55631892
18MP0004510_myositis2.50823509
19MP0002148_abnormal_hypersensitivity_rea2.48623592
20* MP0002419_abnormal_innate_immunity2.39139937
21* MP0002166_altered_tumor_susceptibility2.37953711
22MP0004947_skin_inflammation2.26436688
23* MP0002398_abnormal_bone_marrow2.22770243
24MP0003303_peritoneal_inflammation2.19164659
25* MP0000716_abnormal_immune_system2.10497681
26MP0002405_respiratory_system_inflammati2.09135891
27MP0003300_gastrointestinal_ulcer2.06768207
28MP0010155_abnormal_intestine_physiology2.05090493
29* MP0002006_tumorigenesis2.03408929
30MP0008438_abnormal_cutaneous_collagen1.96758032
31MP0009333_abnormal_splenocyte_physiolog1.96530500
32MP0001873_stomach_inflammation1.93127906
33MP0005464_abnormal_platelet_physiology1.89740520
34MP0005451_abnormal_body_composition1.86776426
35MP0001853_heart_inflammation1.85403059
36MP0000689_abnormal_spleen_morphology1.83244255
37* MP0001845_abnormal_inflammatory_respons1.81905152
38MP0002722_abnormal_immune_system1.80682409
39* MP0002429_abnormal_blood_cell1.71346596
40MP0002396_abnormal_hematopoietic_system1.69590310
41MP0005310_abnormal_salivary_gland1.64764478
42* MP0008469_abnormal_protein_level1.57663545
43MP0001533_abnormal_skeleton_physiology1.56546012
44MP0000703_abnormal_thymus_morphology1.55662609
45MP0008260_abnormal_autophagy1.51120502
46MP0002138_abnormal_hepatobiliary_system1.41594781
47MP0003705_abnormal_hypodermis_morpholog1.40166837
48MP0002933_joint_inflammation1.39996591
49MP0003448_altered_tumor_morphology1.39923624
50MP0005058_abnormal_lysosome_morphology1.39887637
51MP0003191_abnormal_cellular_cholesterol1.38049121
52MP0000858_altered_metastatic_potential1.36859097
53MP0003866_abnormal_defecation1.35032752
54MP0001958_emphysema1.34620475
55MP0009764_decreased_sensitivity_to1.31267449
56MP0002254_reproductive_system_inflammat1.30592937
57MP0002877_abnormal_melanocyte_morpholog1.28683615
58MP0004808_abnormal_hematopoietic_stem1.21873992
59MP0005397_hematopoietic_system_phenotyp1.20001554
60MP0001545_abnormal_hematopoietic_system1.20001554
61MP0005275_abnormal_skin_tensile1.14055812
62MP0009278_abnormal_bone_marrow1.11428803
63MP0000465_gastrointestinal_hemorrhage1.06136073
64MP0001851_eye_inflammation1.06065793
65* MP0002998_abnormal_bone_remodeling1.03925084
66MP0009763_increased_sensitivity_to1.03294981
67MP0003045_fibrosis1.02158542
68MP0004883_abnormal_blood_vessel1.01812153
69MP0005164_abnormal_response_to1.01149537
70MP0005023_abnormal_wound_healing1.00977785
71MP0003279_aneurysm0.99907008
72MP0006054_spinal_hemorrhage0.98617492
73MP0003453_abnormal_keratinocyte_physiol0.94896043
74MP0003172_abnormal_lysosome_physiology0.94023075
75MP0009840_abnormal_foam_cell0.90304986
76MP0000609_abnormal_liver_physiology0.84948688
77MP0003690_abnormal_glial_cell0.80396998
78MP0002019_abnormal_tumor_incidence0.78743671
79MP0000604_amyloidosis0.77760578
80MP0004381_abnormal_hair_follicle0.77489964
81MP0003566_abnormal_cell_adhesion0.76271260
82MP0010352_gastrointestinal_tract_polyps0.75962004
83* MP0000343_altered_response_to0.74674885
84MP0000569_abnormal_digit_pigmentation0.72659368
85MP0003091_abnormal_cell_migration0.72658139
86MP0002136_abnormal_kidney_physiology0.72464363
87MP0000249_abnormal_blood_vessel0.71765985
88MP0000490_abnormal_crypts_of0.70172479
89MP0003075_altered_response_to0.69874075
90MP0005166_decreased_susceptibility_to0.68355094
91MP0009765_abnormal_xenobiotic_induced0.67914418
92MP0002139_abnormal_hepatobiliary_system0.66519681
93MP0001348_abnormal_lacrimal_gland0.66041999
94MP0005174_abnormal_tail_pigmentation0.65637782
95MP0003183_abnormal_peptide_metabolism0.64596142
96MP0005076_abnormal_cell_differentiation0.62847430
97MP0005390_skeleton_phenotype0.62161211
98MP0004782_abnormal_surfactant_physiolog0.61126067
99MP0002009_preneoplasia0.61095432
100MP0001663_abnormal_digestive_system0.60701133
101* MP0005621_abnormal_cell_physiology0.60270600
102MP0000767_abnormal_smooth_muscle0.59588795
103MP0003656_abnormal_erythrocyte_physiolo0.59398194
104MP0000920_abnormal_myelination0.59163394
105MP0001542_abnormal_bone_strength0.58822945
106MP0001216_abnormal_epidermal_layer0.57718597
107MP0001191_abnormal_skin_condition0.56776133
108MP0002277_abnormal_respiratory_mucosa0.56170767
109MP0010307_abnormal_tumor_latency0.55833463
110MP0005075_abnormal_melanosome_morpholog0.54917834
111* MP0003795_abnormal_bone_structure0.54917140
112MP0000371_diluted_coat_color0.54687419
113* MP0000598_abnormal_liver_morphology0.52263335
114MP0001881_abnormal_mammary_gland0.51994979
115MP0009115_abnormal_fat_cell0.50802756
116MP0010234_abnormal_vibrissa_follicle0.50160322
117MP0005360_urolithiasis0.49793352
118MP0009643_abnormal_urine_homeostasis0.49721468
119MP0003828_pulmonary_edema0.47061432

Predicted human phenotypes

RankGene SetZ-score
1Chronic otitis media (HP:0000389)5.89345063
2Elevated erythrocyte sedimentation rate (HP:0003565)5.43536418
3Eczematoid dermatitis (HP:0000976)5.40238805
4Recurrent bronchitis (HP:0002837)5.05916003
5Abnormality of T cell number (HP:0011839)4.68849086
6Recurrent abscess formation (HP:0002722)4.63064791
7Nasal polyposis (HP:0100582)4.61781706
8T lymphocytopenia (HP:0005403)4.59513547
9Abnormality of the nasal mucosa (HP:0000433)4.28372699
10Myositis (HP:0100614)4.28170580
11Recurrent bacterial skin infections (HP:0005406)4.17230606
12* Recurrent fungal infections (HP:0002841)4.14891689
13Autoimmune thrombocytopenia (HP:0001973)4.07422993
14Abnormality of T cells (HP:0002843)3.88599247
15* Recurrent viral infections (HP:0004429)3.85556152
16Pustule (HP:0200039)3.66913117
17Abnormal delayed hypersensitivity skin test (HP:0002963)3.66433073
18Recurrent gram-negative bacterial infections (HP:0005420)3.58573676
19Vasculitis (HP:0002633)3.51879757
20Orchitis (HP:0100796)3.46090587
21Severe combined immunodeficiency (HP:0004430)3.43734344
22Panhypogammaglobulinemia (HP:0003139)3.39078928
23Increased IgM level (HP:0003496)3.36014573
24Mediastinal lymphadenopathy (HP:0100721)3.34995109
25Combined immunodeficiency (HP:0005387)3.32868593
26Chronic diarrhea (HP:0002028)3.31090748
27IgM deficiency (HP:0002850)3.29202817
28Optic neuritis (HP:0100653)3.26335105
29Retrobulbar optic neuritis (HP:0100654)3.26335105
30Chronic sinusitis (HP:0011109)3.26332099
31Agammaglobulinemia (HP:0004432)3.25715129
32Stomatitis (HP:0010280)3.24246855
33Autoimmune hemolytic anemia (HP:0001890)3.23306161
34* Recurrent skin infections (HP:0001581)3.23123027
35IgG deficiency (HP:0004315)3.20343808
36Abnormality of T cell physiology (HP:0011840)3.17503203
37* Chronic mucocutaneous candidiasis (HP:0002728)3.17294326
38* Recurrent cutaneous fungal infections (HP:0011370)3.17294326
39Abnormality of macrophages (HP:0004311)3.09578512
40Meningitis (HP:0001287)3.09217509
41Inflammation of the large intestine (HP:0002037)3.08094294
42Spontaneous hematomas (HP:0007420)3.07229627
43Colitis (HP:0002583)3.05493209
44Lymphopenia (HP:0001888)3.03809980
45Hypergammaglobulinemia (HP:0010702)3.02598705
46Abnormality of cells of the lymphoid lineage (HP:0012140)2.99351017
47Leukocytosis (HP:0001974)2.98563408
48Gastrointestinal inflammation (HP:0004386)2.95982442
49Abnormality of eosinophils (HP:0001879)2.95051280
50Eosinophilia (HP:0001880)2.93862598
51Abnormality of the fingertips (HP:0001211)2.88260415
52Thyroiditis (HP:0100646)2.82312682
53Pulmonary infiltrates (HP:0002113)2.80404643
54Bronchitis (HP:0012387)2.80185231
55Cellulitis (HP:0100658)2.75822870
56Chronic obstructive pulmonary disease (HP:0006510)2.75376948
57Obstructive lung disease (HP:0006536)2.75376948
58Interstitial pulmonary disease (HP:0006530)2.75055875
59Basal ganglia calcification (HP:0002135)2.72220792
60Periodontitis (HP:0000704)2.72050529
61Joint swelling (HP:0001386)2.71933574
62Increased IgE level (HP:0003212)2.71401946
63Peritonitis (HP:0002586)2.69389915
64Gingival bleeding (HP:0000225)2.66865384
65Gingivitis (HP:0000230)2.65365682
66Emphysema (HP:0002097)2.63509324
67Granulocytopenia (HP:0001913)2.62928431
68Arterial thrombosis (HP:0004420)2.59875194
69Thrombocytosis (HP:0001894)2.58465422
70Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.55282317
71IgA deficiency (HP:0002720)2.55083801
72Recurrent sinusitis (HP:0011108)2.50444378
73Hypoplasia of the thymus (HP:0000778)2.49094808
74Encephalitis (HP:0002383)2.47646987
75Gastrointestinal stroma tumor (HP:0100723)2.44469802
76Gastrointestinal infarctions (HP:0005244)2.43128242
77Keratoconjunctivitis sicca (HP:0001097)2.42442628
78Systemic lupus erythematosus (HP:0002725)2.35397573
79Abnormality of the peritoneum (HP:0002585)2.32748455
80Hematochezia (HP:0002573)2.32337009
81Keratoconjunctivitis (HP:0001096)2.32011274
82Epistaxis (HP:0000421)2.31603064
83B lymphocytopenia (HP:0010976)2.30354714
84Abnormality of B cell number (HP:0010975)2.30354714
85Spondylolisthesis (HP:0003302)2.26117144
86Pulmonary embolism (HP:0002204)2.25163380
87Dilatation of the ascending aorta (HP:0005111)2.22669210
88Petechiae (HP:0000967)2.22610646
89* Hemoptysis (HP:0002105)2.22310765
90Fatigue (HP:0012378)2.21628976
91Myocardial infarction (HP:0001658)2.20329087
92Vacuolated lymphocytes (HP:0001922)2.19765116
93Abnormality of glycolipid metabolism (HP:0010969)2.17631776
94Abnormality of liposaccharide metabolism (HP:0010968)2.17631776
95Abnormality of glycosphingolipid metabolism (HP:0004343)2.17631776
96Premature loss of primary teeth (HP:0006323)2.15662822
97Restrictive lung disease (HP:0002091)2.14431819
98* Skin ulcer (HP:0200042)2.13913771
99Viral hepatitis (HP:0006562)2.12558055
100Osteomyelitis (HP:0002754)2.11640400
101Increased cerebral lipofuscin (HP:0011813)2.08847975
102Abnormal platelet volume (HP:0011876)2.07092771
103Recurrent lower respiratory tract infections (HP:0002783)2.06356259
104Verrucae (HP:0200043)2.05701320
105Papilloma (HP:0012740)2.05701320
106Urticaria (HP:0001025)2.05691216
107Chest pain (HP:0100749)2.05402825
108Protrusio acetabuli (HP:0003179)2.03590160
109Abnormality of the prostate (HP:0008775)2.03523210
110Lymphoma (HP:0002665)2.00983035
111Purpura (HP:0000979)2.00545196
112Glomerulopathy (HP:0100820)2.00516914
113Gangrene (HP:0100758)1.98974789
114Abnormality of the pleura (HP:0002103)1.98292090
115Prolonged bleeding time (HP:0003010)1.97942245
116Malnutrition (HP:0004395)1.95953700
117Arthralgia (HP:0002829)1.95296850
118Microcytic anemia (HP:0001935)1.94005926
119Loss of speech (HP:0002371)1.93796558
120Recurrent pneumonia (HP:0006532)1.92557981
121Osteolytic defects of the hand bones (HP:0009699)1.91899747
122Osteolytic defects of the phalanges of the hand (HP:0009771)1.91899747
123Aortic aneurysm (HP:0004942)1.89105662
124Premature rupture of membranes (HP:0001788)1.84121277

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.19439868
2TXK4.32920119
3PRPF4B3.60643884
4* TYK23.48704507
5TBK13.37883439
6MAP3K143.22593826
7* IKBKE3.14141375
8* JAK32.68686193
9ZAP702.65185363
10* JAK12.57191993
11BLK2.37734998
12IRAK42.23863626
13ITK2.16425999
14STK102.14332797
15MAP3K131.86882886
16CSK1.85843633
17ERN11.80994271
18IKBKB1.77689490
19* LCK1.69078847
20* FGFR41.66675621
21SYK1.64760378
22BTK1.62710638
23TEC1.62090264
24TGFBR21.59414269
25KDR1.58699745
26SMG11.57713960
27CSF1R1.56289316
28EPHB11.51041766
29HCK1.50816326
30GRK61.47182189
31NLK1.42821205
32EPHA31.39289879
33CDC42BPA1.38211596
34IRAK31.28450745
35LRRK21.28114510
36CHUK1.27910130
37BMPR21.24730350
38* KIT1.21310310
39DDR21.21244589
40NME21.20024910
41PKN21.18343028
42LYN1.08411279
43MARK31.07343545
44PRKCH1.06857617
45TAOK31.06642416
46MAP3K101.05765578
47FLT31.04206904
48PDGFRA1.03160591
49GRK71.02902603
50RPS6KA41.02745869
51* FGFR31.02722255
52RIPK41.00439324
53PRKCQ0.99513652
54TRIB30.99156320
55* JAK20.99030154
56PIM10.93328205
57FES0.91134768
58TTN0.89589431
59TAOK20.89336559
60NEK90.88104861
61MAP3K10.87685748
62MST40.87512127
63EEF2K0.80314094
64MAP2K30.77229950
65CLK10.76576888
66PTK60.75554200
67PIK3CG0.72556509
68TGFBR10.71044890
69KSR20.68305204
70IRAK10.68159128
71SIK10.67975536
72MELK0.66463388
73SCYL20.64691525
74PIM20.63836418
75YES10.62786744
76SIK20.62270838
77PRKD20.60363871
78PDK10.60270586
79STK240.56597515
80STK40.55051961
81RIPK10.54155288
82PDPK10.53607905
83CDK60.50660876
84EIF2AK30.50012282
85CDK120.48738300
86SIK30.48396516
87PDGFRB0.47991638
88CDK40.47475538
89ABL10.47285398
90TESK20.46529486
91TRPM70.46420175
92IGF1R0.45486807
93TNK20.45358609
94HIPK20.43854426
95FYN0.42231225
96PASK0.42222315
97MAP3K70.41950824
98MAP3K20.41540562
99SGK30.40325305
100* MAPK110.39763535
101INSR0.39180770
102* EGFR0.36873018
103MARK20.35651564
104MAP3K50.35548553
105TAOK10.35332133
106MAPK120.34700552
107MST1R0.32943487
108MAPKAPK20.31479640
109* PRKCD0.30431650
110CAMK1D0.30190838
111FGR0.29189791
112NUAK10.28496337
113RPS6KA60.28453360
114EIF2AK20.27074090
115MAPK40.25801644
116MATK0.25509646
117CDK90.25033434
118DMPK0.24280681
119MAP3K30.22422513
120* MAPK30.22373539
121ALK0.21062648
122MAPK70.20124333
123TIE10.19081905
124* SRC0.17747954
125MAP3K80.15259658
126RET0.15073691
127RPS6KC10.14836598

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.44697991
2* Measles_Homo sapiens_hsa051623.01110532
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.99748225
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.78894384
5Antigen processing and presentation_Homo sapiens_hsa046122.69794137
6RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.56016540
7* Leishmaniasis_Homo sapiens_hsa051402.55999086
8* Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.45960188
9Staphylococcus aureus infection_Homo sapiens_hsa051502.44023128
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.36496420
11Allograft rejection_Homo sapiens_hsa053302.36484120
12T cell receptor signaling pathway_Homo sapiens_hsa046602.33174341
13* Osteoclast differentiation_Homo sapiens_hsa043802.21566816
14Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.20254215
15* Toll-like receptor signaling pathway_Homo sapiens_hsa046202.16788787
16Graft-versus-host disease_Homo sapiens_hsa053322.14448954
17B cell receptor signaling pathway_Homo sapiens_hsa046622.05303420
18* Herpes simplex infection_Homo sapiens_hsa051682.01621648
19Hematopoietic cell lineage_Homo sapiens_hsa046401.94699224
20Caffeine metabolism_Homo sapiens_hsa002321.88366795
21* Influenza A_Homo sapiens_hsa051641.84463643
22* Jak-STAT signaling pathway_Homo sapiens_hsa046301.83172749
23* Toxoplasmosis_Homo sapiens_hsa051451.69791779
24Viral myocarditis_Homo sapiens_hsa054161.67718612
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.65902229
26Pertussis_Homo sapiens_hsa051331.58951741
27Legionellosis_Homo sapiens_hsa051341.57723977
28Malaria_Homo sapiens_hsa051441.55668911
29TNF signaling pathway_Homo sapiens_hsa046681.53250288
30Autoimmune thyroid disease_Homo sapiens_hsa053201.45385815
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.44811096
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.41838124
33Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.36876842
34* Tuberculosis_Homo sapiens_hsa051521.36163155
35* Chemokine signaling pathway_Homo sapiens_hsa040621.36139265
36Apoptosis_Homo sapiens_hsa042101.35306791
37* Hepatitis B_Homo sapiens_hsa051611.31726674
38* Hepatitis C_Homo sapiens_hsa051601.28064045
39Leukocyte transendothelial migration_Homo sapiens_hsa046701.27016243
40Shigellosis_Homo sapiens_hsa051311.23251780
41Asthma_Homo sapiens_hsa053101.17768301
42Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.04016985
43Acute myeloid leukemia_Homo sapiens_hsa052211.03618543
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.02914914
45Salmonella infection_Homo sapiens_hsa051320.99107481
46African trypanosomiasis_Homo sapiens_hsa051430.97292482
47Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.95032453
48Type I diabetes mellitus_Homo sapiens_hsa049400.92762557
49Rheumatoid arthritis_Homo sapiens_hsa053230.86981411
50Platelet activation_Homo sapiens_hsa046110.85060226
51Lysosome_Homo sapiens_hsa041420.84343226
52* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80504748
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80357709
54Chronic myeloid leukemia_Homo sapiens_hsa052200.77675569
55Other glycan degradation_Homo sapiens_hsa005110.77042659
56Small cell lung cancer_Homo sapiens_hsa052220.73500870
57Complement and coagulation cascades_Homo sapiens_hsa046100.73429966
58Viral carcinogenesis_Homo sapiens_hsa052030.72021849
59Glycosaminoglycan degradation_Homo sapiens_hsa005310.71872950
60HTLV-I infection_Homo sapiens_hsa051660.70506918
61Renal cell carcinoma_Homo sapiens_hsa052110.70392114
62Epstein-Barr virus infection_Homo sapiens_hsa051690.70095417
63* Pancreatic cancer_Homo sapiens_hsa052120.68024919
64ABC transporters_Homo sapiens_hsa020100.66685560
65* Prolactin signaling pathway_Homo sapiens_hsa049170.66516598
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65728914
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.60973066
68Bladder cancer_Homo sapiens_hsa052190.56765889
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55053694
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53039312
71Insulin resistance_Homo sapiens_hsa049310.51978012
72Endometrial cancer_Homo sapiens_hsa052130.50769806
73Notch signaling pathway_Homo sapiens_hsa043300.50191178
74Phagosome_Homo sapiens_hsa041450.48764714
75Systemic lupus erythematosus_Homo sapiens_hsa053220.48310070
76VEGF signaling pathway_Homo sapiens_hsa043700.47690183
77Dorso-ventral axis formation_Homo sapiens_hsa043200.47375594
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45623561
79Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.45105871
80Amoebiasis_Homo sapiens_hsa051460.44925816
81Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.44894101
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.44640186
83p53 signaling pathway_Homo sapiens_hsa041150.39414569
84mTOR signaling pathway_Homo sapiens_hsa041500.39363784
85Prion diseases_Homo sapiens_hsa050200.39280538
86HIF-1 signaling pathway_Homo sapiens_hsa040660.37451022
87Glioma_Homo sapiens_hsa052140.35826229
88Thyroid cancer_Homo sapiens_hsa052160.35781450
89Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34757086
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.33565677
91Inositol phosphate metabolism_Homo sapiens_hsa005620.32746070
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.31937580
93Endocytosis_Homo sapiens_hsa041440.29500619
94GnRH signaling pathway_Homo sapiens_hsa049120.29065790
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.28033539
96Primary bile acid biosynthesis_Homo sapiens_hsa001200.25728052
97ErbB signaling pathway_Homo sapiens_hsa040120.24381908
98Non-small cell lung cancer_Homo sapiens_hsa052230.24306746
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.22978813
100Proteoglycans in cancer_Homo sapiens_hsa052050.22154436
101Focal adhesion_Homo sapiens_hsa045100.20788799
102FoxO signaling pathway_Homo sapiens_hsa040680.19930480
103PPAR signaling pathway_Homo sapiens_hsa033200.19496334
104Colorectal cancer_Homo sapiens_hsa052100.19028718
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.17440407
106Adherens junction_Homo sapiens_hsa045200.13925868
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.13131366
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.11860752
109Phosphatidylinositol signaling system_Homo sapiens_hsa040700.11506093
110MicroRNAs in cancer_Homo sapiens_hsa052060.11442348
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.11350608
112Lysine degradation_Homo sapiens_hsa003100.11329947
113Pentose phosphate pathway_Homo sapiens_hsa000300.09926149
114Prostate cancer_Homo sapiens_hsa052150.08965281
115* Pathways in cancer_Homo sapiens_hsa052000.07945337
116Rap1 signaling pathway_Homo sapiens_hsa040150.07784237

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