STARD7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.79707395
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.19131946
3L-phenylalanine catabolic process (GO:0006559)6.19131946
4nuclear pore organization (GO:0006999)6.09069145
5DNA unwinding involved in DNA replication (GO:0006268)5.96198691
6L-phenylalanine metabolic process (GO:0006558)5.90616109
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.90616109
8lysine catabolic process (GO:0006554)5.55134714
9lysine metabolic process (GO:0006553)5.55134714
10alpha-linolenic acid metabolic process (GO:0036109)5.29279017
11aromatic amino acid family catabolic process (GO:0009074)5.18673103
12pore complex assembly (GO:0046931)5.13998389
13cellular ketone body metabolic process (GO:0046950)5.10651827
14glyoxylate metabolic process (GO:0046487)5.07214640
15kynurenine metabolic process (GO:0070189)4.95060621
16triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.92927296
17mitotic chromosome condensation (GO:0007076)4.89153101
18DNA strand elongation involved in DNA replication (GO:0006271)4.86782986
19DNA strand elongation (GO:0022616)4.70980720
20establishment of integrated proviral latency (GO:0075713)4.66938905
21aspartate family amino acid catabolic process (GO:0009068)4.62964682
22fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.59591331
23mitotic sister chromatid cohesion (GO:0007064)4.57904294
242-oxoglutarate metabolic process (GO:0006103)4.51501252
25bile acid biosynthetic process (GO:0006699)4.50423736
26ketone body metabolic process (GO:1902224)4.45318349
27urea cycle (GO:0000050)4.44710491
28urea metabolic process (GO:0019627)4.44710491
29tryptophan catabolic process (GO:0006569)4.42797043
30indole-containing compound catabolic process (GO:0042436)4.42797043
31indolalkylamine catabolic process (GO:0046218)4.42797043
32regulation of translational fidelity (GO:0006450)4.40956876
33tryptophan metabolic process (GO:0006568)4.34973966
34high-density lipoprotein particle remodeling (GO:0034375)4.33699079
35dicarboxylic acid biosynthetic process (GO:0043650)4.31817106
36cysteine metabolic process (GO:0006534)4.31097259
37protein complex localization (GO:0031503)4.22638529
38carnitine shuttle (GO:0006853)4.18069437
39fatty acid transmembrane transport (GO:1902001)4.16982803
40short-chain fatty acid metabolic process (GO:0046459)4.11374125
41acetyl-CoA metabolic process (GO:0006084)4.08121515
42homocysteine metabolic process (GO:0050667)4.07217949
43regulation of triglyceride catabolic process (GO:0010896)4.05915618
44protein localization to chromosome, centromeric region (GO:0071459)4.05278316
45sulfur amino acid catabolic process (GO:0000098)4.05208055
46ribosome assembly (GO:0042255)4.05072221
47nitrogen cycle metabolic process (GO:0071941)4.01654647
48telomere maintenance via semi-conservative replication (GO:0032201)4.00435362
49fatty acid beta-oxidation (GO:0006635)3.98567761
50DNA replication initiation (GO:0006270)3.97885141
51cellular protein complex localization (GO:0034629)3.96453314
52alpha-amino acid catabolic process (GO:1901606)3.96444229
53glutamate metabolic process (GO:0006536)3.93785103
54mitotic nuclear envelope disassembly (GO:0007077)3.92600603
55regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.84699594
56formation of translation preinitiation complex (GO:0001731)3.84586350
57cellular modified amino acid catabolic process (GO:0042219)3.80753333
58bile acid metabolic process (GO:0008206)3.78932658
59complement activation, alternative pathway (GO:0006957)3.78501442
60pre-miRNA processing (GO:0031054)3.77688301
61reverse cholesterol transport (GO:0043691)3.76152232
62fatty acid oxidation (GO:0019395)3.75356026
63DNA duplex unwinding (GO:0032508)3.75306520
64spliceosomal tri-snRNP complex assembly (GO:0000244)3.74874278
65amino-acid betaine metabolic process (GO:0006577)3.74806871
66mitotic metaphase plate congression (GO:0007080)3.72713199
67regulation of protein activation cascade (GO:2000257)3.72614238
68membrane disassembly (GO:0030397)3.71250969
69nuclear envelope disassembly (GO:0051081)3.71250969
70cellular amino acid catabolic process (GO:0009063)3.70952950
71serine family amino acid catabolic process (GO:0009071)3.70490038
72negative regulation of fibrinolysis (GO:0051918)3.70450810
73tyrosine metabolic process (GO:0006570)3.70005912
74aromatic amino acid family metabolic process (GO:0009072)3.69284227
75coenzyme catabolic process (GO:0009109)3.67137611
76lipid oxidation (GO:0034440)3.66964132
77fatty acid catabolic process (GO:0009062)3.65886416
78protein-lipid complex remodeling (GO:0034368)3.65368254
79macromolecular complex remodeling (GO:0034367)3.65368254
80plasma lipoprotein particle remodeling (GO:0034369)3.65368254
81positive regulation of chromosome segregation (GO:0051984)3.64296381
82acylglycerol homeostasis (GO:0055090)3.63812454
83triglyceride homeostasis (GO:0070328)3.63812454
84protein localization to kinetochore (GO:0034501)3.63059743
85IMP biosynthetic process (GO:0006188)3.61868011
86DNA geometric change (GO:0032392)3.61816134
87DNA topological change (GO:0006265)3.58987641
88IMP metabolic process (GO:0046040)3.58073038
89monocarboxylic acid catabolic process (GO:0072329)3.57742367
90negative regulation of cholesterol transport (GO:0032375)3.55437477
91negative regulation of sterol transport (GO:0032372)3.55437477
92valine metabolic process (GO:0006573)3.54706136
93hyperosmotic salinity response (GO:0042538)3.53534120
94regulation of fibrinolysis (GO:0051917)3.52827163
95pyrimidine nucleobase catabolic process (GO:0006208)3.52321287
96phospholipid efflux (GO:0033700)3.51790580
97phospholipid homeostasis (GO:0055091)3.51343534
98proline biosynthetic process (GO:0006561)3.51328586
99non-recombinational repair (GO:0000726)3.51229091
100double-strand break repair via nonhomologous end joining (GO:0006303)3.51229091
101regulation of sister chromatid cohesion (GO:0007063)3.49071159
102positive regulation of fatty acid beta-oxidation (GO:0032000)3.48738134
103regulation of cholesterol esterification (GO:0010872)3.48511888
104tricarboxylic acid metabolic process (GO:0072350)3.46989144
105regulation of complement activation (GO:0030449)3.46402279
106telomere maintenance via recombination (GO:0000722)3.46218452
107sister chromatid segregation (GO:0000819)3.45545996
108mitotic sister chromatid segregation (GO:0000070)3.44191814
109protein carboxylation (GO:0018214)3.42638482
110peptidyl-glutamic acid carboxylation (GO:0017187)3.42638482
111ethanol oxidation (GO:0006069)3.40348436
112carboxylic acid catabolic process (GO:0046395)3.39394191
113organic acid catabolic process (GO:0016054)3.39394191
114establishment of viral latency (GO:0019043)3.38478475
115folic acid-containing compound biosynthetic process (GO:0009396)3.38307805
116oxaloacetate metabolic process (GO:0006107)3.36652567
117dicarboxylic acid catabolic process (GO:0043649)3.36520501
118regulation of fatty acid oxidation (GO:0046320)3.34734313
119tricarboxylic acid cycle (GO:0006099)3.34579457
120mitotic recombination (GO:0006312)3.32999334
121negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.32830736
122regulation of fatty acid beta-oxidation (GO:0031998)3.30602669
123plasma lipoprotein particle clearance (GO:0034381)3.30211551
124regulation of RNA export from nucleus (GO:0046831)3.27170395
125drug catabolic process (GO:0042737)3.24460735
126succinate metabolic process (GO:0006105)3.23941573
127positive regulation of fatty acid oxidation (GO:0046321)3.22077074
128branched-chain amino acid catabolic process (GO:0009083)3.20566824
129tRNA aminoacylation for protein translation (GO:0006418)3.18931956
130cholesterol efflux (GO:0033344)3.18693742
131indolalkylamine metabolic process (GO:0006586)3.17890565
132positive regulation of lipid catabolic process (GO:0050996)3.17211648
133nucleobase-containing small molecule interconversion (GO:0015949)3.16530062
134carnitine transmembrane transport (GO:1902603)3.15508574
135regulation of cholesterol homeostasis (GO:2000188)3.15484440
136carnitine transport (GO:0015879)3.13689281
137amino-acid betaine transport (GO:0015838)3.13689281
138branched-chain amino acid metabolic process (GO:0009081)3.13644634
139glycine metabolic process (GO:0006544)3.12507404
140serine family amino acid metabolic process (GO:0009069)3.11051249
141amino acid activation (GO:0043038)3.09122203
142tRNA aminoacylation (GO:0043039)3.09122203
143nucleobase catabolic process (GO:0046113)3.07511886
144L-serine metabolic process (GO:0006563)3.07448556
145fatty acid homeostasis (GO:0055089)3.05845162
146DNA conformation change (GO:0071103)3.05594794
147benzene-containing compound metabolic process (GO:0042537)3.05469791
148thioester biosynthetic process (GO:0035384)3.04283621
149acyl-CoA biosynthetic process (GO:0071616)3.04283621
150NADH metabolic process (GO:0006734)3.02193280
151drug transmembrane transport (GO:0006855)3.02001998
152negative regulation of mRNA processing (GO:0050686)2.98365607
153regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.96660660
154establishment of chromosome localization (GO:0051303)2.91959023
155nuclear envelope organization (GO:0006998)2.91827429
156Golgi transport vesicle coating (GO:0048200)2.91045833
157COPI coating of Golgi vesicle (GO:0048205)2.91045833
158pteridine-containing compound biosynthetic process (GO:0042559)2.88882001
159DNA replication-dependent nucleosome assembly (GO:0006335)2.88432108
160DNA replication-dependent nucleosome organization (GO:0034723)2.88432108
161RNA stabilization (GO:0043489)2.88421280
162mRNA stabilization (GO:0048255)2.88421280
163purine nucleobase biosynthetic process (GO:0009113)2.88022790
164metaphase plate congression (GO:0051310)2.87912675
165nucleobase biosynthetic process (GO:0046112)2.87033728
166negative regulation of mRNA metabolic process (GO:1903312)2.86451128
167glutamine metabolic process (GO:0006541)2.82859796
168mRNA transport (GO:0051028)2.82859574
169positive regulation of cell cycle checkpoint (GO:1901978)2.81803382
170regulation of mitotic spindle organization (GO:0060236)2.81248307
171mitochondrial fusion (GO:0008053)2.79080515
172protein export from nucleus (GO:0006611)2.78040650
173peptidyl-arginine omega-N-methylation (GO:0035247)2.77603234
174regulation of histone H3-K9 methylation (GO:0051570)2.76937894
175regulation of nucleobase-containing compound transport (GO:0032239)2.76559169
176cellular hyperosmotic response (GO:0071474)2.73834699
177nucleotide-excision repair, DNA gap filling (GO:0006297)2.73357552
178peptidyl-lysine dimethylation (GO:0018027)2.72715015
179rRNA transcription (GO:0009303)2.72633642
180chromosome condensation (GO:0030261)2.72005970
181regulation of chromosome segregation (GO:0051983)2.71346930
182transcription from mitochondrial promoter (GO:0006390)2.69383591
183regulation of translational elongation (GO:0006448)2.67709332
184regulation of centriole replication (GO:0046599)2.66683523
185histone arginine methylation (GO:0034969)2.65658486
186telomere maintenance via telomere lengthening (GO:0010833)2.64964821
187protein localization to chromosome (GO:0034502)2.64878649
188regulation of translational termination (GO:0006449)2.64274254
189ribosome biogenesis (GO:0042254)2.63538103
190DNA replication checkpoint (GO:0000076)2.59337491
191RNA transport (GO:0050658)2.58471667
192establishment of RNA localization (GO:0051236)2.58471667
193nucleic acid transport (GO:0050657)2.58471667
194viral mRNA export from host cell nucleus (GO:0046784)2.58370141
195mitochondrial DNA metabolic process (GO:0032042)2.57634880
196mRNA export from nucleus (GO:0006406)2.56556137
197RNA export from nucleus (GO:0006405)2.55095713
198regulation of spindle organization (GO:0090224)2.54100858
199positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.52627756

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.26436706
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.35086626
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.57264392
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.48112558
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.04802869
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.28569848
7MYC_18555785_ChIP-Seq_MESCs_Mouse4.10502651
8FOXM1_23109430_ChIP-Seq_U2OS_Human4.05904090
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.83237690
10E2F4_17652178_ChIP-ChIP_JURKAT_Human3.76494995
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.74164922
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.47800809
13AR_21909140_ChIP-Seq_LNCAP_Human3.20202594
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.03054607
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.84511472
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.83571231
17KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.81346767
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.81311939
19CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.76173433
20TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.69630889
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.69403306
22* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.59228832
23* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.55778679
24E2F1_21310950_ChIP-Seq_MCF-7_Human2.54504236
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.50714020
26* ZFX_18555785_ChIP-Seq_MESCs_Mouse2.49600895
27MYCN_18555785_ChIP-Seq_MESCs_Mouse2.32115356
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.31893118
29MYC_22102868_ChIP-Seq_BL_Human2.31771666
30GATA1_22025678_ChIP-Seq_K562_Human2.26644018
31THAP11_20581084_ChIP-Seq_MESCs_Mouse2.26594152
32CREB1_15753290_ChIP-ChIP_HEK293T_Human2.24743975
33POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.19858641
34E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.10895198
35ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.04209518
36YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.01706813
37E2F7_22180533_ChIP-Seq_HELA_Human10.6444406
38CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.99022696
39XRN2_22483619_ChIP-Seq_HELA_Human1.95672625
40TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.93333213
41PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.92326449
42CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.90856932
43CLOCK_20551151_ChIP-Seq_293T_Human1.90036157
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.89438991
45RBPJ_22232070_ChIP-Seq_NCS_Mouse1.87929063
46JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.86468074
47PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.83458215
48* FOXA2_19822575_ChIP-Seq_HepG2_Human1.79603199
49E2F1_18555785_ChIP-Seq_MESCs_Mouse1.78310749
50EGR1_19374776_ChIP-ChIP_THP-1_Human1.77475498
51DCP1A_22483619_ChIP-Seq_HELA_Human1.76168802
52ETS1_20019798_ChIP-Seq_JURKAT_Human1.74837483
53CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.69027214
54CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.68412071
55* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.68080310
56STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.63943526
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.58215849
58KLF4_18555785_ChIP-Seq_MESCs_Mouse1.56515828
59CIITA_25753668_ChIP-Seq_RAJI_Human1.56494608
60CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.53282921
61ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.52879053
62FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.51774947
63NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.50717885
64EST1_17652178_ChIP-ChIP_JURKAT_Human1.48949171
65NANOG_18555785_ChIP-Seq_MESCs_Mouse1.48913137
66MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.48711809
67* TTF2_22483619_ChIP-Seq_HELA_Human1.45108108
68DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.43869773
69* GABP_19822575_ChIP-Seq_HepG2_Human1.40532153
70CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.37372148
71ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.37049842
72FOXP3_21729870_ChIP-Seq_TREG_Human1.34434577
73PADI4_21655091_ChIP-ChIP_MCF-7_Human1.32566004
74ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.32129006
75BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.30241006
76* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.30097539
77HTT_18923047_ChIP-ChIP_STHdh_Human1.29524420
78HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27903277
79* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.27215734
80DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.26794829
81NANOG_21062744_ChIP-ChIP_HESCs_Human1.25269012
82TFEB_21752829_ChIP-Seq_HELA_Human1.25262018
83ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.23214995
84* HNF4A_19822575_ChIP-Seq_HepG2_Human1.22390420
85E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.21940859
86TBX20_22328084_ChIP-Seq_HEART_Mouse1.20645194
87TBX20_22080862_ChIP-Seq_HEART_Mouse1.20645194
88STAT3_1855785_ChIP-Seq_MESCs_Mouse1.19429665
89SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.17452925
90* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.17108378
91GABP_17652178_ChIP-ChIP_JURKAT_Human1.16946279
92* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.16105248
93* KDM5A_27292631_Chip-Seq_BREAST_Human1.15697170
94GATA4_21415370_ChIP-Seq_HL-1_Mouse1.14408591
95ZNF263_19887448_ChIP-Seq_K562_Human1.12734148
96EP300_21415370_ChIP-Seq_HL-1_Mouse1.11444225
97SALL1_21062744_ChIP-ChIP_HESCs_Human1.11276049
98* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.09402675
99ESR1_20079471_ChIP-ChIP_T-47D_Human1.09358917
100YY1_21170310_ChIP-Seq_MESCs_Mouse1.07757204
101CHD1_26751641_Chip-Seq_LNCaP_Human1.06870985
102SOX17_20123909_ChIP-Seq_XEN_Mouse1.05851552
103NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.05343203
104AR_21572438_ChIP-Seq_LNCaP_Human1.05262942
105POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.05054785
106NR3C1_23031785_ChIP-Seq_PC12_Mouse1.04872316
107TAF15_26573619_Chip-Seq_HEK293_Human1.04677525
108AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.04651766
109BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04022341
110TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03752013
111ELK1_19687146_ChIP-ChIP_HELA_Human1.03176193
112TBX5_21415370_ChIP-Seq_HL-1_Mouse1.02271239
113SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99089498
114DROSHA_22980978_ChIP-Seq_HELA_Human0.98036483
115NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.97851027
116SOX2_21211035_ChIP-Seq_LN229_Gbm0.97327353
117GATA1_19941826_ChIP-Seq_K562_Human0.94724313
118RARB_27405468_Chip-Seq_BRAIN_Mouse0.93857263
119SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.91976122
120ELF1_17652178_ChIP-ChIP_JURKAT_Human0.91270747
121CBP_21632823_ChIP-Seq_H3396_Human0.90317006
122* VDR_23849224_ChIP-Seq_CD4+_Human0.90191016
123* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.89836002
124* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89305023
125THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.88802823
126SRF_21415370_ChIP-Seq_HL-1_Mouse0.88628082
127ZNF274_21170338_ChIP-Seq_K562_Hela0.87578292
128ESR1_15608294_ChIP-ChIP_MCF-7_Human0.87495273
129HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.87225674
130EGR1_19032775_ChIP-ChIP_M12_Human0.87044780
131PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.85951754
132NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.85534985
133EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.84970879
134NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.84771734
135SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.84526771
136FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.83300507
137GBX2_23144817_ChIP-Seq_PC3_Human0.83016510
138MTF2_20144788_ChIP-Seq_MESCs_Mouse0.82483126
139REST_18959480_ChIP-ChIP_MESCs_Mouse0.80627146
140SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.79399512
141SOX2_27498859_Chip-Seq_STOMACH_Mouse0.78562139
142GATA1_19941827_ChIP-Seq_MEL_Mouse0.78045670
143IGF1R_20145208_ChIP-Seq_DFB_Human0.77874562
144CREB1_26743006_Chip-Seq_LNCaP_Human0.77533302
145PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.76869658
146BCAT_22108803_ChIP-Seq_LS180_Human0.76702643
147ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.75575763
148NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.75374237
149DNAJC2_21179169_ChIP-ChIP_NT2_Human0.75297677
150FOXA1_25552417_ChIP-Seq_VCAP_Human0.73148245
151AR_19668381_ChIP-Seq_PC3_Human0.73027274
152* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.72941469
153SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.72891019
154CBP_20019798_ChIP-Seq_JUKART_Human0.72334085
155IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.72334085
156LXR_22292898_ChIP-Seq_THP-1_Human0.71992248
157AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.71552362
158ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.71057331
159REST_21632747_ChIP-Seq_MESCs_Mouse0.68335643
160* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.68135202
161GATA2_19941826_ChIP-Seq_K562_Human0.66779714
162GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.66750909
163POU3F2_20337985_ChIP-ChIP_501MEL_Human0.66393915
164TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.66374485
165PIAS1_25552417_ChIP-Seq_VCAP_Human0.64781332
166AUTS2_25519132_ChIP-Seq_293T-REX_Human0.64301364
167KDM2B_26808549_Chip-Seq_K562_Human0.64010014
168FOXO3_23340844_ChIP-Seq_DLD1_Human0.63778570
169SMAD4_21741376_ChIP-Seq_HESCs_Human0.63204164
170* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.63007744
171MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.62910928
172GATA4_25053715_ChIP-Seq_YYC3_Human0.60553478
173* GATA3_26560356_Chip-Seq_TH1_Human0.60283836
174SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.60001039
175ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.58676541
176SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.58446883
177* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.58341724
178TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.58221287
179SMAD4_21799915_ChIP-Seq_A2780_Human0.58149544
180KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.57533984
181EZH2_27294783_Chip-Seq_ESCs_Mouse0.57048321
182TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.56828317
183FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.56652475
184SMAD4_21741376_ChIP-Seq_EPCs_Human0.56531264
185NFIB_24661679_ChIP-Seq_LUNG_Mouse0.56479699
186WT1_25993318_ChIP-Seq_PODOCYTE_Human0.56353689
187SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.56312736
188DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.55571262
189CTCF_27219007_Chip-Seq_Bcells_Human0.55304276
190* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.55230667
191CEBPB_22108803_ChIP-Seq_LS180_Human0.55224411

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.45076167
2MP0005360_urolithiasis6.02327079
3MP0005085_abnormal_gallbladder_physiolo5.11777853
4MP0005365_abnormal_bile_salt4.90255045
5MP0010094_abnormal_chromosome_stability4.49634120
6MP0008057_abnormal_DNA_replication4.25589192
7MP0003111_abnormal_nucleus_morphology4.07208920
8MP0008875_abnormal_xenobiotic_pharmacok3.74293688
9MP0003693_abnormal_embryo_hatching3.66329744
10MP0004957_abnormal_blastocyst_morpholog3.59206336
11MP0003252_abnormal_bile_duct3.42845095
12MP0003077_abnormal_cell_cycle3.30395405
13MP0002877_abnormal_melanocyte_morpholog3.09997617
14MP0010329_abnormal_lipoprotein_level2.94335972
15MP0010352_gastrointestinal_tract_polyps2.87455255
16MP0002837_dystrophic_cardiac_calcinosis2.83757203
17MP0001730_embryonic_growth_arrest2.70724601
18MP0003806_abnormal_nucleotide_metabolis2.65699332
19MP0008932_abnormal_embryonic_tissue2.62147006
20MP0009840_abnormal_foam_cell2.53539245
21MP0008058_abnormal_DNA_repair2.50558785
22MP0005332_abnormal_amino_acid2.38688084
23MP0005083_abnormal_biliary_tract2.35887484
24MP0001666_abnormal_nutrient_absorption2.35780834
25MP0004130_abnormal_muscle_cell2.28842476
26MP0008007_abnormal_cellular_replicative2.23741872
27MP0003195_calcinosis2.16890007
28MP0003011_delayed_dark_adaptation2.11571451
29MP0009672_abnormal_birth_weight2.10052098
30MP0000350_abnormal_cell_proliferation2.05293503
31MP0003890_abnormal_embryonic-extraembry2.02808695
32MP0000751_myopathy1.97432301
33MP0002118_abnormal_lipid_homeostasis1.96697679
34MP0005380_embryogenesis_phenotype1.96478313
35MP0001672_abnormal_embryogenesis/_devel1.96478313
36MP0003646_muscle_fatigue1.88149937
37MP0002009_preneoplasia1.86723377
38MP0002138_abnormal_hepatobiliary_system1.80459244
39MP0003984_embryonic_growth_retardation1.79633740
40MP0005451_abnormal_body_composition1.78114405
41MP0005551_abnormal_eye_electrophysiolog1.77987744
42MP0000609_abnormal_liver_physiology1.77566691
43MP0002088_abnormal_embryonic_growth/wei1.70516610
44MP0003868_abnormal_feces_composition1.70426447
45MP0001697_abnormal_embryo_size1.69640555
46MP0002396_abnormal_hematopoietic_system1.69102257
47MP0002080_prenatal_lethality1.68531335
48MP0004215_abnormal_myocardial_fiber1.66481391
49MP0003941_abnormal_skin_development1.62419234
50MP0010234_abnormal_vibrissa_follicle1.56210505
51MP0005584_abnormal_enzyme/coenzyme_acti1.54338979
52MP0009780_abnormal_chondrocyte_physiolo1.51034886
53MP0002084_abnormal_developmental_patter1.47270971
54MP0005666_abnormal_adipose_tissue1.44320109
55MP0005319_abnormal_enzyme/_coenzyme1.43885000
56MP0004019_abnormal_vitamin_homeostasis1.43466472
57MP0005187_abnormal_penis_morphology1.43432154
58MP0003191_abnormal_cellular_cholesterol1.41211925
59MP0003718_maternal_effect1.40859472
60MP0005330_cardiomyopathy1.39648327
61MP0000747_muscle_weakness1.39432626
62MP0006036_abnormal_mitochondrial_physio1.39104945
63MP0001764_abnormal_homeostasis1.37554171
64MP0002971_abnormal_brown_adipose1.36005940
65MP0002085_abnormal_embryonic_tissue1.35587545
66MP0000313_abnormal_cell_death1.35455156
67MP0004036_abnormal_muscle_relaxation1.35020321
68MP0002086_abnormal_extraembryonic_tissu1.34129133
69MP0001849_ear_inflammation1.33311983
70MP0002078_abnormal_glucose_homeostasis1.30005517
71MP0003329_amyloid_beta_deposits1.26839367
72MP0010307_abnormal_tumor_latency1.26080803
73MP0004145_abnormal_muscle_electrophysio1.24812743
74MP0000372_irregular_coat_pigmentation1.24408829
75MP0004185_abnormal_adipocyte_glucose1.22969709
76MP0004043_abnormal_pH_regulation1.22323372
77MP0004197_abnormal_fetal_growth/weight/1.21922609
78MP0004084_abnormal_cardiac_muscle1.20469631
79MP0004087_abnormal_muscle_fiber1.19327010
80MP0000604_amyloidosis1.18416914
81MP0000358_abnormal_cell_content/1.18248646
82MP0000537_abnormal_urethra_morphology1.12778471
83MP0003221_abnormal_cardiomyocyte_apopto1.08587950
84MP0003705_abnormal_hypodermis_morpholog1.06754665
85MP0009643_abnormal_urine_homeostasis1.04940786
86MP0002269_muscular_atrophy1.04515949
87MP0000749_muscle_degeneration1.04459674
88MP0005535_abnormal_body_temperature1.04345141
89MP0008260_abnormal_autophagy1.03708010
90MP0004233_abnormal_muscle_weight1.02541215
91MP0005384_cellular_phenotype1.01929651
92MP0004808_abnormal_hematopoietic_stem0.99119483
93MP0005620_abnormal_muscle_contractility0.98397993
94MP0005423_abnormal_somatic_nervous0.98283114
95MP0005621_abnormal_cell_physiology0.98177029
96MP0003656_abnormal_erythrocyte_physiolo0.98018398
97MP0003137_abnormal_impulse_conducting0.97642579
98MP0009703_decreased_birth_body0.94856668
99MP0002090_abnormal_vision0.94096198
100MP0006035_abnormal_mitochondrial_morpho0.93103359
101MP0003950_abnormal_plasma_membrane0.92491057
102MP0005334_abnormal_fat_pad0.92264759
103MP0008961_abnormal_basal_metabolism0.91032904
104MP0003136_yellow_coat_color0.90044748
105MP0001915_intracranial_hemorrhage0.89019484
106MP0005253_abnormal_eye_physiology0.88717342
107MP0002972_abnormal_cardiac_muscle0.87981765
108MP0000490_abnormal_crypts_of0.85840549
109MP0003786_premature_aging0.84952481
110MP0005670_abnormal_white_adipose0.84127122
111MP0005375_adipose_tissue_phenotype0.82504040
112MP0002697_abnormal_eye_size0.82291048
113MP0005636_abnormal_mineral_homeostasis0.81842980
114MP0000598_abnormal_liver_morphology0.81619825
115MP0010368_abnormal_lymphatic_system0.80494198
116MP0005076_abnormal_cell_differentiation0.80292673
117MP0004859_abnormal_synaptic_plasticity0.80170047
118MP0001661_extended_life_span0.77887261
119MP0005266_abnormal_metabolism0.77274643
120MP0003567_abnormal_fetal_cardiomyocyte0.77108551
121MP0002092_abnormal_eye_morphology0.77047001
122MP0006072_abnormal_retinal_apoptosis0.76166207
123MP0010630_abnormal_cardiac_muscle0.75957202
124MP0002166_altered_tumor_susceptibility0.75624270
125MP0009697_abnormal_copulation0.75391317
126MP0001293_anophthalmia0.75327174
127MP0005220_abnormal_exocrine_pancreas0.75126629
128MP0000733_abnormal_muscle_development0.74852853
129MP0005448_abnormal_energy_balance0.74629605
130MP0002019_abnormal_tumor_incidence0.74540497
131MP0002254_reproductive_system_inflammat0.74357655
132MP0002106_abnormal_muscle_physiology0.73200993
133MP0005385_cardiovascular_system_phenoty0.73094623
134MP0001544_abnormal_cardiovascular_syste0.73094623
135MP0005408_hypopigmentation0.71383574
136MP0009642_abnormal_blood_homeostasis0.71377535
137MP0004085_abnormal_heartbeat0.71297812
138MP0003123_paternal_imprinting0.71143426
139MP0005171_absent_coat_pigmentation0.70859053
140MP0000428_abnormal_craniofacial_morphol0.70475726
141MP0002229_neurodegeneration0.69508110
142MP0001765_abnormal_ion_homeostasis0.69243708
143MP0008775_abnormal_heart_ventricle0.69026566
144MP0002876_abnormal_thyroid_physiology0.67559824
145MP0000230_abnormal_systemic_arterial0.64166583
146MP0002909_abnormal_adrenal_gland0.64101864
147MP0005647_abnormal_sex_gland0.63846964
148MP0005501_abnormal_skin_physiology0.63111070
149MP0004510_myositis0.62953120
150MP0004270_analgesia0.62909336
151MP0003315_abnormal_perineum_morphology0.62204483
152MP0003690_abnormal_glial_cell0.61492423
153MP0000759_abnormal_skeletal_muscle0.60883419
154MP0003861_abnormal_nervous_system0.60802892
155MP0006138_congestive_heart_failure0.60497261
156MP0005369_muscle_phenotype0.59343213
157MP0004484_altered_response_of0.59035115
158MP0003953_abnormal_hormone_level0.58805576
159MP0005084_abnormal_gallbladder_morpholo0.58596582
160MP0005257_abnormal_intraocular_pressure0.57898210
161MP0003566_abnormal_cell_adhesion0.57839649
162MP0005376_homeostasis/metabolism_phenot0.56624699
163MP0001727_abnormal_embryo_implantation0.56025697
164MP0002006_tumorigenesis0.56007658
165MP0001853_heart_inflammation0.54677137
166MP0003699_abnormal_female_reproductive0.54423415
167MP0000377_abnormal_hair_follicle0.53984457
168MP0000015_abnormal_ear_pigmentation0.52683829
169MP0002114_abnormal_axial_skeleton0.52035494
170MP0000266_abnormal_heart_morphology0.51838248
171MP0003943_abnormal_hepatobiliary_system0.50232299

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.08488304
2Intrahepatic cholestasis (HP:0001406)4.96712381
3Deep venous thrombosis (HP:0002625)4.94230237
4Ketosis (HP:0001946)4.79194354
5Ketoacidosis (HP:0001993)4.54083458
6Hypoglycemic coma (HP:0001325)4.42780951
7Xanthomatosis (HP:0000991)4.41077199
8Multiple enchondromatosis (HP:0005701)4.15214663
9Hypobetalipoproteinemia (HP:0003563)4.06263681
10Hyperammonemia (HP:0001987)4.01703182
11Chromosomal breakage induced by crosslinking agents (HP:0003221)4.00238932
12Abnormality of monocarboxylic acid metabolism (HP:0010996)3.97153814
13Chromsome breakage (HP:0040012)3.83125925
14Hyperlipoproteinemia (HP:0010980)3.76800556
15Myoglobinuria (HP:0002913)3.67784626
16Abnormality of fatty-acid metabolism (HP:0004359)3.55825316
17Nemaline bodies (HP:0003798)3.49332678
18Hypolipoproteinemia (HP:0010981)3.43864154
19Exercise-induced myalgia (HP:0003738)3.42599589
20Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.34547765
21Hypoalphalipoproteinemia (HP:0003233)3.34525790
22Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.33829406
23Epidermoid cyst (HP:0200040)3.33603283
24Prolonged partial thromboplastin time (HP:0003645)3.32430014
25Complement deficiency (HP:0004431)3.32346110
26Abnormality of glycine metabolism (HP:0010895)3.29522090
27Abnormality of serine family amino acid metabolism (HP:0010894)3.29522090
28Microvesicular hepatic steatosis (HP:0001414)3.27300370
29Hyperglycinuria (HP:0003108)3.22849715
30Abnormality of glycolysis (HP:0004366)3.20422282
31Centrally nucleated skeletal muscle fibers (HP:0003687)3.18373821
32Progressive muscle weakness (HP:0003323)3.14974750
33Cortical dysplasia (HP:0002539)3.08682831
34Hyperglycinemia (HP:0002154)3.07578691
35Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.03885344
36Abnormality of glutamine family amino acid metabolism (HP:0010902)2.99087979
37Increased serum pyruvate (HP:0003542)2.95867042
38Exercise-induced muscle cramps (HP:0003710)2.95361621
39Progressive external ophthalmoplegia (HP:0000590)2.92967950
40Abnormality of the left ventricular outflow tract (HP:0011103)2.87318641
41Subaortic stenosis (HP:0001682)2.87318641
42Central scotoma (HP:0000603)2.86467538
43Abnormality of the common coagulation pathway (HP:0010990)2.86024369
44Abnormality of aspartate family amino acid metabolism (HP:0010899)2.84154190
45Abnormality of sulfur amino acid metabolism (HP:0004339)2.77590019
46Dysmetric saccades (HP:0000641)2.77472559
47Metabolic acidosis (HP:0001942)2.74161483
48Rhabdomyolysis (HP:0003201)2.69922478
49Hyperinsulinemic hypoglycemia (HP:0000825)2.68098197
50Gout (HP:0001997)2.67074914
51Dicarboxylic aciduria (HP:0003215)2.66960778
52Abnormality of dicarboxylic acid metabolism (HP:0010995)2.66960778
53Increased nuchal translucency (HP:0010880)2.60522799
54Hyperacusis (HP:0010780)2.60254838
55Conjugated hyperbilirubinemia (HP:0002908)2.58391847
56Insomnia (HP:0100785)2.57522637
57Abnormality of methionine metabolism (HP:0010901)2.57418375
58Pigmentary retinal degeneration (HP:0001146)2.55400151
59Cholelithiasis (HP:0001081)2.54184141
60Abnormal gallbladder physiology (HP:0012438)2.54033090
61Cholecystitis (HP:0001082)2.54033090
62Rimmed vacuoles (HP:0003805)2.52120548
63Abnormal gallbladder morphology (HP:0012437)2.51505954
64Chorioretinal atrophy (HP:0000533)2.50921674
65Late onset (HP:0003584)2.50700725
66Sudden death (HP:0001699)2.50512656
67Nephroblastoma (Wilms tumor) (HP:0002667)2.50476738
68Hypoglycemic seizures (HP:0002173)2.49803522
69Fat malabsorption (HP:0002630)2.46200403
70Hyperbilirubinemia (HP:0002904)2.45766168
71Generalized aminoaciduria (HP:0002909)2.42487830
72Abnormality of the intrinsic pathway (HP:0010989)2.42422263
73Hypercholesterolemia (HP:0003124)2.41588980
74Hepatocellular carcinoma (HP:0001402)2.40990240
75Abnormality of purine metabolism (HP:0004352)2.40726390
76Cerebral edema (HP:0002181)2.40271103
77Skin nodule (HP:0200036)2.39137462
78Abnormality of serum amino acid levels (HP:0003112)2.38133765
79Congenital stationary night blindness (HP:0007642)2.37108008
80Embryonal renal neoplasm (HP:0011794)2.36407779
81Delayed CNS myelination (HP:0002188)2.29095047
82Hyperglycemia (HP:0003074)2.28503606
83Bundle branch block (HP:0011710)2.26892261
84Abnormality of nucleobase metabolism (HP:0010932)2.26441826
85Distal lower limb muscle weakness (HP:0009053)2.26298497
86Overriding aorta (HP:0002623)2.25332176
87Muscle hypertrophy of the lower extremities (HP:0008968)2.20944444
88Medulloblastoma (HP:0002885)2.19505824
89Joint hemorrhage (HP:0005261)2.18499832
90Calf muscle hypertrophy (HP:0008981)2.18313375
91EMG: myopathic abnormalities (HP:0003458)2.17129109
92Ragged-red muscle fibers (HP:0003200)2.15811122
93Asymmetric septal hypertrophy (HP:0001670)2.15649534
94Limb-girdle muscle atrophy (HP:0003797)2.14525349
95Asymmetry of the thorax (HP:0001555)2.12763429
96Abnormality of the gallbladder (HP:0005264)2.12760980
97Abnormal cartilage morphology (HP:0002763)2.07358308
98Hyporeflexia of lower limbs (HP:0002600)2.05285769
99Microglossia (HP:0000171)2.04131020
100Abnormality of complement system (HP:0005339)2.03455033
101Papillary thyroid carcinoma (HP:0002895)2.03429547
102Premature ovarian failure (HP:0008209)2.03114858
103Lethargy (HP:0001254)2.02139030
104Neonatal onset (HP:0003623)2.00673997
105Hyperuricemia (HP:0002149)1.98035932
106Increased purine levels (HP:0004368)1.98035932
107Abnormality of pyrimidine metabolism (HP:0004353)1.97872698
108Sensorimotor neuropathy (HP:0007141)1.97755242
109Proximal tubulopathy (HP:0000114)1.94733814
110Abnormality of chromosome stability (HP:0003220)1.92602466
111Urinary urgency (HP:0000012)1.92388275
112Acanthocytosis (HP:0001927)1.91977886
113Bony spicule pigmentary retinopathy (HP:0007737)1.91966342
114Neoplasm of the adrenal gland (HP:0100631)1.91558996
115Pancreatic islet-cell hyperplasia (HP:0004510)1.90150613
116Abnormality of the pancreatic islet cells (HP:0006476)1.88604411
117Abnormality of endocrine pancreas physiology (HP:0012093)1.88604411
118Vomiting (HP:0002013)1.87894231
119Myopathic facies (HP:0002058)1.86709403
120Scapular winging (HP:0003691)1.85969258
121Spontaneous abortion (HP:0005268)1.85930862
122Hammertoe (HP:0001765)1.85930089
123Uterine leiomyosarcoma (HP:0002891)1.85260956
124Leiomyosarcoma (HP:0100243)1.85260956
125Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.84941241
126Palpitations (HP:0001962)1.83511028
127Birth length less than 3rd percentile (HP:0003561)1.82559530
128Syncope (HP:0001279)1.82428764
129Selective tooth agenesis (HP:0001592)1.81200689
130Ankyloglossia (HP:0010296)1.80858502
131Abnormality of the preputium (HP:0100587)1.80144238
132Gastrointestinal carcinoma (HP:0002672)1.80084099
133Malignant gastrointestinal tract tumors (HP:0006749)1.80084099
134Scotoma (HP:0000575)1.79865391
135Missing ribs (HP:0000921)1.79555672
136Elfin facies (HP:0004428)1.77760748
137Areflexia of lower limbs (HP:0002522)1.77637943
138Muscle fiber inclusion bodies (HP:0100299)1.77475850
139Spastic diplegia (HP:0001264)1.77189069
140Conjunctival hamartoma (HP:0100780)1.77131097
141Achilles tendon contracture (HP:0001771)1.77065198
142Impaired social interactions (HP:0000735)1.76917056
143Abnormal social behavior (HP:0012433)1.76917056
144Acute hepatic failure (HP:0006554)1.75072184
145Lymphangioma (HP:0100764)1.74999028
146Overlapping toe (HP:0001845)1.74692923
147Metatarsus adductus (HP:0001840)1.74418625
148Brushfield spots (HP:0001088)1.74138696
149Pheochromocytoma (HP:0002666)1.73756163
150Cafe-au-lait spot (HP:0000957)1.73062791
151Termporal pattern (HP:0011008)1.72686955
152Insidious onset (HP:0003587)1.72686955
153Muscle stiffness (HP:0003552)1.72022922
154Atrioventricular block (HP:0001678)1.70043059
155Calcaneovalgus deformity (HP:0001848)1.69536207
156Embryonal neoplasm (HP:0002898)1.69353234
157Breech presentation (HP:0001623)1.69088242
158Proximal placement of thumb (HP:0009623)1.68911644
159Abnormal lung lobation (HP:0002101)1.68811936
160Deviation of the thumb (HP:0009603)1.68511907
161Impaired proprioception (HP:0010831)1.68336644
162Difficulty running (HP:0009046)1.67509737
163Ependymoma (HP:0002888)1.67139230
164Deep philtrum (HP:0002002)1.66313490
165Cutaneous melanoma (HP:0012056)1.65647829
166Meckel diverticulum (HP:0002245)1.64252692
167Abnormality of the foot musculature (HP:0001436)1.64239964
168Hepatoblastoma (HP:0002884)1.64075840
169Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.63789942
170Hypokinesia (HP:0002375)1.63619127
171Shoulder girdle muscle weakness (HP:0003547)1.62952750
172Foot dorsiflexor weakness (HP:0009027)1.61616466
173Transitional cell carcinoma of the bladder (HP:0006740)1.59923623
174Renal duplication (HP:0000075)1.59087774
175Dysphonia (HP:0001618)1.59072141
176Neck muscle weakness (HP:0000467)1.58945118
177Abnormality of oral frenula (HP:0000190)1.58072258
178Back pain (HP:0003418)1.57598956
179Flat acetabular roof (HP:0003180)1.55709339
180Abnormality of the calf musculature (HP:0001430)1.54324691
181Secondary amenorrhea (HP:0000869)1.54212336
182Bowel incontinence (HP:0002607)1.54189061
183Type 1 muscle fiber predominance (HP:0003803)1.53792211
184Increased connective tissue (HP:0009025)1.53319673
185Postnatal microcephaly (HP:0005484)1.53057001
186Abnormality of pain sensation (HP:0010832)1.52896319
187Impaired pain sensation (HP:0007328)1.52896319

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PKN24.01854872
2BCKDK3.93020034
3CDC73.60719369
4TRIB33.44346832
5SRPK13.26190401
6TSSK63.24044439
7TTK3.04105586
8OBSCN2.78090509
9EIF2AK32.72199529
10SMG12.63725841
11INSRR2.60571065
12BUB12.54164382
13PHKG22.52809690
14PHKG12.52809690
15PBK2.46867253
16KSR22.36609103
17MAP3K132.25599910
18EIF2AK12.19712781
19MAP2K42.06637336
20MARK12.01858704
21CDK122.01757092
22MAP3K91.84296577
23SIK11.81339894
24TTN1.81115014
25RET1.67637488
26NEK11.67101327
27PDK41.64627814
28PDK31.64627814
29TAOK31.63123675
30LATS21.60335649
31FRK1.58601764
32MAP3K71.55639280
33RPS6KB21.51766998
34LMTK21.50896187
35FGFR41.50224676
36PTK61.49130358
37FGFR21.43317820
38ALK1.42800541
39PIK3CG1.42740816
40WEE11.42737478
41MAP3K41.42098372
42MAP3K101.41353176
43ICK1.40367794
44KSR11.39287518
45FLT31.35674935
46MAPK111.31930795
47RIPK11.31705775
48TAF11.29872366
49STK241.25384363
50CHEK21.24421163
51PRKAA21.23912075
52VRK21.22581883
53NTRK31.22071274
54ATR1.18716813
55MKNK11.18224156
56CCNB11.17589686
57ERN11.16785002
58PLK31.16067801
59SCYL21.13359434
60CDK71.13250992
61PKN11.12738865
62DAPK21.10593815
63MKNK21.10115068
64CHEK11.09792017
65CDK61.08776500
66PRKD31.08402768
67MAPK121.07551625
68PLK11.06059683
69NME21.04362019
70PINK11.03673728
71MAP3K81.03358155
72PRKCH1.02117744
73EEF2K1.02112596
74PRKAA11.01240486
75CAMK1D1.00054387
76PAK60.99037657
77AURKB0.97307003
78RPS6KA40.95981890
79PRPF4B0.95819008
80JAK20.95698027
81PLK40.95203441
82PAK30.92874611
83ATM0.87530512
84CAMK1G0.86115258
85PIK3CA0.85671890
86MAP3K20.85450354
87EIF2AK20.81006281
88MAPKAPK30.79762129
89CDK40.79617852
90WNK40.77521253
91CDK20.75764419
92MST40.75312384
93MAP3K60.74063375
94SGK4940.73339039
95SGK2230.73339039
96DAPK10.72814543
97PRKCZ0.72748051
98RPS6KB10.72673629
99PDGFRA0.71243254
100ARAF0.70694366
101CDK10.69903568
102SGK30.69682323
103STK30.69246988
104NEK90.68972481
105MTOR0.68329411
106AURKA0.67056480
107PDK10.66255502
108ERBB40.65359700
109PAK40.65254064
110EPHA30.64890316
111MAP3K50.64784219
112RAF10.64595418
113DMPK0.63708986
114PDPK10.62946830
115BRSK10.62807287
116CAMKK10.61799471
117JAK10.59971251
118LATS10.59021677
119BRAF0.58114870
120STK40.58104297
121FGFR30.57970568
122SGK10.57014750
123CSNK1E0.56033341
124MAP2K70.55515021
125VRK10.54282897
126MINK10.53701010
127BRSK20.53609440
128PRKACG0.53500260
129BCR0.53040469
130CLK10.52625094
131PRKDC0.52374757
132ZAK0.51472362
133SGK20.51126469
134GRK10.50067251
135IRAK20.48601922
136NEK20.47771955
137CDK90.47564232
138BRD40.46327701
139STK110.46001099
140PDK20.45913746
141STK38L0.45528631
142CDK180.45423747
143CDK50.44872637
144MAPK100.44667065
145MAPKAPK50.44567000
146MAP3K10.44090142
147MUSK0.43928078
148CDK150.43201472
149PRKCQ0.43171982
150CSNK2A20.43102926
151NEK60.42711381
152UHMK10.42685978
153RPS6KA30.42616259
154CSNK1G30.41669776
155MAP2K10.41579873
156AKT20.41073032
157CDK140.40567354
158CDK80.39440788
159MAPK130.39102342
160PRKD10.38925611
161STK390.38246602
162CDK11A0.37380906
163ILK0.37344346
164CSNK1D0.37300739
165TYK20.36491272
166ERBB20.35984784
167MAP2K60.35811043
168CSNK1G10.35259005
169MAPK140.33699779
170FGFR10.32624682
171CAMK2A0.32039344
172EPHB10.31440273
173NTRK20.31077452
174CAMK40.30806584

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.22759097
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.03267094
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.53995859
4Primary bile acid biosynthesis_Homo sapiens_hsa001203.46125364
5Nitrogen metabolism_Homo sapiens_hsa009103.45091929
6Mismatch repair_Homo sapiens_hsa034303.27031694
7Non-homologous end-joining_Homo sapiens_hsa034503.20750731
8Fatty acid degradation_Homo sapiens_hsa000713.01966285
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.83254367
10Arginine biosynthesis_Homo sapiens_hsa002202.76975903
11Propanoate metabolism_Homo sapiens_hsa006402.69657543
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.61812131
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.61036458
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.57386697
15Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.54629569
16Butanoate metabolism_Homo sapiens_hsa006502.47588063
17Tryptophan metabolism_Homo sapiens_hsa003802.41480532
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.39758226
19Fatty acid metabolism_Homo sapiens_hsa012122.35712885
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.32425094
21Cell cycle_Homo sapiens_hsa041102.32272473
22Base excision repair_Homo sapiens_hsa034102.30869761
23RNA transport_Homo sapiens_hsa030132.29426358
24Spliceosome_Homo sapiens_hsa030402.15151223
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.12591881
26Nucleotide excision repair_Homo sapiens_hsa034202.02922272
27Vitamin B6 metabolism_Homo sapiens_hsa007501.92350409
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.87122323
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.85737899
30PPAR signaling pathway_Homo sapiens_hsa033201.82503316
31mRNA surveillance pathway_Homo sapiens_hsa030151.80376820
32Proteasome_Homo sapiens_hsa030501.79010938
33Peroxisome_Homo sapiens_hsa041461.77770427
34Pyruvate metabolism_Homo sapiens_hsa006201.76416409
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.69089033
36Carbon metabolism_Homo sapiens_hsa012001.64345877
37Complement and coagulation cascades_Homo sapiens_hsa046101.56282263
38Phototransduction_Homo sapiens_hsa047441.53630316
39beta-Alanine metabolism_Homo sapiens_hsa004101.53545311
40Bile secretion_Homo sapiens_hsa049761.45029748
41Caffeine metabolism_Homo sapiens_hsa002321.44891869
42Fatty acid elongation_Homo sapiens_hsa000621.44125454
43Starch and sucrose metabolism_Homo sapiens_hsa005001.37339719
44Biosynthesis of amino acids_Homo sapiens_hsa012301.36628854
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.36260472
46Selenocompound metabolism_Homo sapiens_hsa004501.35489205
47Pentose and glucuronate interconversions_Homo sapiens_hsa000401.35124340
48Sulfur metabolism_Homo sapiens_hsa009201.32534532
49Phenylalanine metabolism_Homo sapiens_hsa003601.25498333
50Thyroid cancer_Homo sapiens_hsa052161.22802037
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.18768734
52Histidine metabolism_Homo sapiens_hsa003401.16088908
53Fat digestion and absorption_Homo sapiens_hsa049751.13838497
54Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.12986723
55Pyrimidine metabolism_Homo sapiens_hsa002401.12861470
56ABC transporters_Homo sapiens_hsa020101.11850806
57Maturity onset diabetes of the young_Homo sapiens_hsa049501.11654820
58Lysine degradation_Homo sapiens_hsa003101.09420281
59RNA degradation_Homo sapiens_hsa030181.07062212
60Oocyte meiosis_Homo sapiens_hsa041141.05238683
61Cysteine and methionine metabolism_Homo sapiens_hsa002701.05174863
62Fanconi anemia pathway_Homo sapiens_hsa034601.03457104
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.03169913
64Retinol metabolism_Homo sapiens_hsa008301.01709337
65Chemical carcinogenesis_Homo sapiens_hsa052040.99430495
66Tyrosine metabolism_Homo sapiens_hsa003500.96070019
67Drug metabolism - other enzymes_Homo sapiens_hsa009830.92466351
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.92220951
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.91643080
70Homologous recombination_Homo sapiens_hsa034400.90427841
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89568772
72RNA polymerase_Homo sapiens_hsa030200.88753498
73Adherens junction_Homo sapiens_hsa045200.88721253
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86690001
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84969084
76Chronic myeloid leukemia_Homo sapiens_hsa052200.84500924
77Fatty acid biosynthesis_Homo sapiens_hsa000610.81248679
78Basal transcription factors_Homo sapiens_hsa030220.80460751
79Insulin resistance_Homo sapiens_hsa049310.77564115
80Non-small cell lung cancer_Homo sapiens_hsa052230.76172793
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.73532886
82Systemic lupus erythematosus_Homo sapiens_hsa053220.73000697
83Arginine and proline metabolism_Homo sapiens_hsa003300.72304003
84Glucagon signaling pathway_Homo sapiens_hsa049220.71512814
85MicroRNAs in cancer_Homo sapiens_hsa052060.71154187
86Folate biosynthesis_Homo sapiens_hsa007900.70041566
87Endometrial cancer_Homo sapiens_hsa052130.69405297
88Viral carcinogenesis_Homo sapiens_hsa052030.69161625
89Glycerolipid metabolism_Homo sapiens_hsa005610.68169903
90Staphylococcus aureus infection_Homo sapiens_hsa051500.66887081
91Colorectal cancer_Homo sapiens_hsa052100.64883255
92Pancreatic cancer_Homo sapiens_hsa052120.64814558
93Purine metabolism_Homo sapiens_hsa002300.62578212
94Epstein-Barr virus infection_Homo sapiens_hsa051690.58347106
95N-Glycan biosynthesis_Homo sapiens_hsa005100.56968493
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56968123
97Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55506126
98AMPK signaling pathway_Homo sapiens_hsa041520.54899472
99Cyanoamino acid metabolism_Homo sapiens_hsa004600.54492873
100Cardiac muscle contraction_Homo sapiens_hsa042600.50346594
101Type II diabetes mellitus_Homo sapiens_hsa049300.49248593
102Insulin signaling pathway_Homo sapiens_hsa049100.48937365
103Bladder cancer_Homo sapiens_hsa052190.47715294
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46988298
105Glioma_Homo sapiens_hsa052140.45340621
106Sulfur relay system_Homo sapiens_hsa041220.44899693
107HTLV-I infection_Homo sapiens_hsa051660.43827965
108Alcoholism_Homo sapiens_hsa050340.43522964
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43346234
110Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41847583
111One carbon pool by folate_Homo sapiens_hsa006700.41802516
112Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.41268549
113Pentose phosphate pathway_Homo sapiens_hsa000300.41071738
114Tight junction_Homo sapiens_hsa045300.39133872
115p53 signaling pathway_Homo sapiens_hsa041150.37140067
116Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.37009465
117Prostate cancer_Homo sapiens_hsa052150.36820746
118Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36325646
119Viral myocarditis_Homo sapiens_hsa054160.36024094
120Hippo signaling pathway_Homo sapiens_hsa043900.35618976
121Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34331495
122Long-term potentiation_Homo sapiens_hsa047200.33762165
123Vibrio cholerae infection_Homo sapiens_hsa051100.33676682
124Vitamin digestion and absorption_Homo sapiens_hsa049770.32784555
125Dilated cardiomyopathy_Homo sapiens_hsa054140.31464976
126Glutathione metabolism_Homo sapiens_hsa004800.31377361
127Inositol phosphate metabolism_Homo sapiens_hsa005620.30695844
128Central carbon metabolism in cancer_Homo sapiens_hsa052300.30693625
129Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.30302395
130Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29844099
131Steroid biosynthesis_Homo sapiens_hsa001000.29350461
132Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28351081
133Herpes simplex infection_Homo sapiens_hsa051680.27440511
134Galactose metabolism_Homo sapiens_hsa000520.27273231
135Renal cell carcinoma_Homo sapiens_hsa052110.27222407
136Metabolic pathways_Homo sapiens_hsa011000.26586528
137GABAergic synapse_Homo sapiens_hsa047270.26297324
138Small cell lung cancer_Homo sapiens_hsa052220.25602649
139Prion diseases_Homo sapiens_hsa050200.24324486
140Fructose and mannose metabolism_Homo sapiens_hsa000510.22855916
141Insulin secretion_Homo sapiens_hsa049110.22589692
142mTOR signaling pathway_Homo sapiens_hsa041500.21642958
143Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.21253905
144Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.20774004
145alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.20167871
146Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.19375760
147Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.18394235
148Circadian rhythm_Homo sapiens_hsa047100.17488483
149Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.16132721
150cGMP-PKG signaling pathway_Homo sapiens_hsa040220.13016372
151Longevity regulating pathway - mammal_Homo sapiens_hsa042110.12400064
152Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.11929983
153Ovarian steroidogenesis_Homo sapiens_hsa049130.09949255
154Aldosterone synthesis and secretion_Homo sapiens_hsa049250.09776533
155Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.09608064
156Circadian entrainment_Homo sapiens_hsa047130.08970377
157Glycerophospholipid metabolism_Homo sapiens_hsa005640.08690774
158Oxytocin signaling pathway_Homo sapiens_hsa049210.07554031
159Renin secretion_Homo sapiens_hsa049240.07114725

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