STAMBP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules. One such signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. The protein encoded by this gene binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)6.33919996
2central nervous system myelination (GO:0022010)6.33919996
3establishment of integrated proviral latency (GO:0075713)4.79596730
4cilium or flagellum-dependent cell motility (GO:0001539)4.67386000
5establishment of protein localization to mitochondrial membrane (GO:0090151)4.64467638
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.57325463
7presynaptic membrane assembly (GO:0097105)4.42880730
8chaperone-mediated protein transport (GO:0072321)4.35440633
9presynaptic membrane organization (GO:0097090)4.32853822
10CENP-A containing nucleosome assembly (GO:0034080)4.31274547
11proteasome assembly (GO:0043248)4.29113522
12chromatin remodeling at centromere (GO:0031055)4.19597300
13rRNA modification (GO:0000154)4.08289134
14long-chain fatty acid biosynthetic process (GO:0042759)4.02303467
15protein K6-linked ubiquitination (GO:0085020)3.99854492
16negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.98892195
17DNA ligation (GO:0006266)3.95617806
18regulation of mitochondrial translation (GO:0070129)3.95174681
19neuron cell-cell adhesion (GO:0007158)3.93016412
20fatty acid elongation (GO:0030497)3.88767425
21ribosomal large subunit biogenesis (GO:0042273)3.84351309
22regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.83997956
23positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.75976183
24establishment of viral latency (GO:0019043)3.75466727
25respiratory chain complex IV assembly (GO:0008535)3.70507266
26protein complex biogenesis (GO:0070271)3.68122114
27histone exchange (GO:0043486)3.67674631
28anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.67614235
29negative regulation of ligase activity (GO:0051352)3.65790001
30negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.65790001
31rRNA methylation (GO:0031167)3.59499539
32negative regulation of synaptic transmission, GABAergic (GO:0032229)3.57669992
33mitochondrial respiratory chain complex assembly (GO:0033108)3.54817710
34ribosomal small subunit biogenesis (GO:0042274)3.53691651
35energy coupled proton transport, down electrochemical gradient (GO:0015985)3.53165686
36ATP synthesis coupled proton transport (GO:0015986)3.53165686
37acrosome reaction (GO:0007340)3.46683616
38regulation of cellular amino acid metabolic process (GO:0006521)3.45316393
39negative regulation of neurotransmitter transport (GO:0051589)3.41414951
40ribosomal small subunit assembly (GO:0000028)3.41371918
41respiratory electron transport chain (GO:0022904)3.41117825
42positive regulation of action potential (GO:0045760)3.39704375
43protein localization to cilium (GO:0061512)3.38283472
44axonemal dynein complex assembly (GO:0070286)3.37638292
45mannosylation (GO:0097502)3.35345514
46DNA replication-independent nucleosome assembly (GO:0006336)3.35316177
47DNA replication-independent nucleosome organization (GO:0034724)3.35316177
48mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.34781431
49mitochondrial respiratory chain complex I assembly (GO:0032981)3.34781431
50NADH dehydrogenase complex assembly (GO:0010257)3.34781431
51mitotic metaphase plate congression (GO:0007080)3.34414926
52DNA strand elongation involved in DNA replication (GO:0006271)3.30921507
53electron transport chain (GO:0022900)3.30483460
54positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.29769794
55formation of translation preinitiation complex (GO:0001731)3.28121355
56double-strand break repair via nonhomologous end joining (GO:0006303)3.27285717
57non-recombinational repair (GO:0000726)3.27285717
58DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.26821556
59ribosome assembly (GO:0042255)3.25397644
60signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.24706235
61intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.24706235
62water-soluble vitamin biosynthetic process (GO:0042364)3.23199929
63cytochrome complex assembly (GO:0017004)3.23134574
64signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.22894049
65signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.22894049
66signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.22894049
67DNA strand elongation (GO:0022616)3.15962085
68signal transduction involved in DNA integrity checkpoint (GO:0072401)3.13258611
69signal transduction involved in DNA damage checkpoint (GO:0072422)3.13258611
70positive regulation of ligase activity (GO:0051351)3.13101251
717-methylguanosine mRNA capping (GO:0006370)3.12617309
72protein localization to kinetochore (GO:0034501)3.11173741
73regulation of collateral sprouting (GO:0048670)3.10212255
74mitotic sister chromatid cohesion (GO:0007064)3.09839750
75single strand break repair (GO:0000012)3.09819388
76epithelial cilium movement (GO:0003351)3.09105533
77regulation of ubiquitin-protein transferase activity (GO:0051438)3.05398675
78telomere maintenance via semi-conservative replication (GO:0032201)3.04834084
79signal transduction involved in cell cycle checkpoint (GO:0072395)3.04413573
80GPI anchor biosynthetic process (GO:0006506)3.03729953
81maturation of SSU-rRNA (GO:0030490)3.03354399
82cellular component biogenesis (GO:0044085)3.03286040
83oligodendrocyte differentiation (GO:0048709)3.03155344
84response to X-ray (GO:0010165)3.03051091
85GPI anchor metabolic process (GO:0006505)3.01692991
867-methylguanosine RNA capping (GO:0009452)3.01502225
87RNA capping (GO:0036260)3.01502225
88nucleobase biosynthetic process (GO:0046112)3.00794840
89epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.00004260
90metaphase plate congression (GO:0051310)2.99530068
91piRNA metabolic process (GO:0034587)2.98552722
92regulation of helicase activity (GO:0051095)2.98178319
93protein targeting to mitochondrion (GO:0006626)2.98014897
94ribonucleoprotein complex biogenesis (GO:0022613)2.97894082
95myelination (GO:0042552)2.96933221
96maturation of 5.8S rRNA (GO:0000460)2.95736481
97DNA replication checkpoint (GO:0000076)2.94760211
98regulation of ligase activity (GO:0051340)2.92361462
99sperm capacitation (GO:0048240)2.91764692
100centriole replication (GO:0007099)2.91330907
101cerebral cortex radially oriented cell migration (GO:0021799)2.90920971
102cilium movement (GO:0003341)2.90483968
103ensheathment of neurons (GO:0007272)2.90096921
104axon ensheathment (GO:0008366)2.90096921
105inner mitochondrial membrane organization (GO:0007007)2.90067262
106translation (GO:0006412)2.89827266
107centriole assembly (GO:0098534)2.88071205
108protein neddylation (GO:0045116)2.86824224
109purine nucleobase biosynthetic process (GO:0009113)2.86222584
110transcription-coupled nucleotide-excision repair (GO:0006283)2.84539208
111transcription elongation from RNA polymerase III promoter (GO:0006385)2.84444069
112termination of RNA polymerase III transcription (GO:0006386)2.84444069
113negative regulation of neurotransmitter secretion (GO:0046929)2.83448415
114pseudouridine synthesis (GO:0001522)2.83127872
115rRNA processing (GO:0006364)2.82751665
116mitotic spindle checkpoint (GO:0071174)2.82188572
117eye photoreceptor cell differentiation (GO:0001754)2.81712566
118photoreceptor cell differentiation (GO:0046530)2.81712566
119negative regulation of execution phase of apoptosis (GO:1900118)2.81527783
120spliceosomal snRNP assembly (GO:0000387)2.80234411
121spindle checkpoint (GO:0031577)2.79916464
122transmission of nerve impulse (GO:0019226)2.79588593
123kinetochore organization (GO:0051383)2.79485741
124establishment of mitochondrion localization (GO:0051654)2.78308090
125NADH metabolic process (GO:0006734)2.78284538
126serotonin receptor signaling pathway (GO:0007210)2.77699438
127protein localization to synapse (GO:0035418)2.77593284
128postsynaptic membrane organization (GO:0001941)2.77425169
129neuronal action potential propagation (GO:0019227)2.77305559
130negative regulation of sister chromatid segregation (GO:0033046)2.77145006
131negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.77145006
132negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.77145006
133negative regulation of mitotic sister chromatid segregation (GO:0033048)2.77145006
134negative regulation of mitotic sister chromatid separation (GO:2000816)2.77145006
135gamma-aminobutyric acid signaling pathway (GO:0007214)2.76889607
136mitotic recombination (GO:0006312)2.76210511
137DNA catabolic process, exonucleolytic (GO:0000738)2.76068063
138preassembly of GPI anchor in ER membrane (GO:0016254)2.75942583
139glycerophospholipid catabolic process (GO:0046475)2.74933707
140regulation of DNA endoreduplication (GO:0032875)2.74127312
141motile cilium assembly (GO:0044458)2.71865488
142ionotropic glutamate receptor signaling pathway (GO:0035235)2.71245593
143regulation of dopamine metabolic process (GO:0042053)2.70123785
144regulation of catecholamine metabolic process (GO:0042069)2.70123785
145response to redox state (GO:0051775)2.68524084
146startle response (GO:0001964)2.66318321
147mechanosensory behavior (GO:0007638)2.65737565
148synaptic vesicle exocytosis (GO:0016079)2.63676456
149neuron-neuron synaptic transmission (GO:0007270)2.61788336
150synaptic transmission, glutamatergic (GO:0035249)2.56395089
151vocalization behavior (GO:0071625)2.55997879
152mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.55839485
153adult walking behavior (GO:0007628)2.55652674
154negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.54090691
155glutamate receptor signaling pathway (GO:0007215)2.52955011
156limb bud formation (GO:0060174)2.51176474
157transferrin transport (GO:0033572)2.50782368
158multicellular organism reproduction (GO:0032504)2.49286836
159neurotransmitter-gated ion channel clustering (GO:0072578)2.49084621
160intraciliary transport (GO:0042073)2.48423338
161developmental pigmentation (GO:0048066)2.47684056
162regulation of synaptic transmission, GABAergic (GO:0032228)2.47634102
163sperm motility (GO:0030317)2.46935454
164magnesium ion transport (GO:0015693)2.46725988
165neurotransmitter uptake (GO:0001504)2.46438104
166cerebellar granule cell differentiation (GO:0021707)2.44794384
167regulation of protein targeting to membrane (GO:0090313)2.43590803
168regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.41848345
169calcium ion-dependent exocytosis (GO:0017156)2.41279759
170positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.41160536
171regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.40962807
172energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.40889545
173ATP hydrolysis coupled proton transport (GO:0015991)2.40889545
174regulation of synaptic vesicle exocytosis (GO:2000300)2.40605284
175positive regulation of synapse assembly (GO:0051965)2.39763029
176phagosome maturation (GO:0090382)2.38136173
177substantia nigra development (GO:0021762)2.38041264
178vesicle docking involved in exocytosis (GO:0006904)2.37775513
179axoneme assembly (GO:0035082)2.37574376
180dendrite development (GO:0016358)2.37141689
181dopamine biosynthetic process (GO:0042416)2.35907032
182C-terminal protein amino acid modification (GO:0018410)2.35245750
183neuron recognition (GO:0008038)2.35039005
184membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.34154358
185pH reduction (GO:0045851)2.33560418
186regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.32528094
187positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.29702263
188ferric iron transport (GO:0015682)2.29622026
189trivalent inorganic cation transport (GO:0072512)2.29622026
190negative regulation of protein localization to cell surface (GO:2000009)2.29229357
191adult locomotory behavior (GO:0008344)2.29012822
192apical protein localization (GO:0045176)2.28931468
193positive regulation of mitochondrial fission (GO:0090141)2.28439574
194response to epinephrine (GO:0071871)2.28267173
195detection of calcium ion (GO:0005513)2.27252955
196L-amino acid import (GO:0043092)2.26830221
197synapse assembly (GO:0007416)2.26368101
198regulation of pigment cell differentiation (GO:0050932)2.26006329
199intracellular pH reduction (GO:0051452)2.25633976

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.14603257
2E2F7_22180533_ChIP-Seq_HELA_Human5.01805301
3* GABP_17652178_ChIP-ChIP_JURKAT_Human4.49707140
4EZH2_22144423_ChIP-Seq_EOC_Human4.38750414
5MYC_18555785_ChIP-Seq_MESCs_Mouse4.05059039
6* EST1_17652178_ChIP-ChIP_JURKAT_Human3.94027163
7GBX2_23144817_ChIP-Seq_PC3_Human3.92231085
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.65522359
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.60930649
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.47230038
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.37136701
12CREB1_15753290_ChIP-ChIP_HEK293T_Human3.34851834
13ETS1_20019798_ChIP-Seq_JURKAT_Human3.05482648
14ELK1_19687146_ChIP-ChIP_HELA_Human3.01621519
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.91374992
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.81049169
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.70007612
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.67929107
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.64196634
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.63962463
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.62364703
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.59898575
23TAF15_26573619_Chip-Seq_HEK293_Human2.58989978
24* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.57497111
25MYC_19079543_ChIP-ChIP_MESCs_Mouse2.52934546
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.47668244
27PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.43414452
28DCP1A_22483619_ChIP-Seq_HELA_Human2.36598156
29THAP11_20581084_ChIP-Seq_MESCs_Mouse2.32029488
30* VDR_23849224_ChIP-Seq_CD4+_Human2.31020580
31AR_21909140_ChIP-Seq_LNCAP_Human2.30450627
32FOXP3_21729870_ChIP-Seq_TREG_Human2.29672964
33FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.24465533
34SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.22006326
35PADI4_21655091_ChIP-ChIP_MCF-7_Human2.21442180
36ELF1_17652178_ChIP-ChIP_JURKAT_Human2.17759239
37SRF_21415370_ChIP-Seq_HL-1_Mouse2.16645493
38TTF2_22483619_ChIP-Seq_HELA_Human2.15453194
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.14816378
40NELFA_20434984_ChIP-Seq_ESCs_Mouse2.13469860
41E2F1_18555785_ChIP-Seq_MESCs_Mouse2.08648368
42KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.06338980
43FOXM1_23109430_ChIP-Seq_U2OS_Human2.06280096
44POU3F2_20337985_ChIP-ChIP_501MEL_Human2.03756862
45MYCN_18555785_ChIP-Seq_MESCs_Mouse2.00914435
46IGF1R_20145208_ChIP-Seq_DFB_Human1.97011165
47SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.96092807
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.93618044
49XRN2_22483619_ChIP-Seq_HELA_Human1.89352545
50JARID2_20064375_ChIP-Seq_MESCs_Mouse1.87835845
51PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.85194679
52* GABP_19822575_ChIP-Seq_HepG2_Human1.82152908
53SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.81051693
54POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.81035096
55VDR_22108803_ChIP-Seq_LS180_Human1.79193999
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.78397060
57HOXB4_20404135_ChIP-ChIP_EML_Mouse1.78287618
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.77910401
59SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.76789872
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.75694699
61CBX2_27304074_Chip-Seq_ESCs_Mouse1.75420637
62SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.74776544
63P300_19829295_ChIP-Seq_ESCs_Human1.74035241
64EZH2_27304074_Chip-Seq_ESCs_Mouse1.73971791
65CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73226285
66SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.72519636
67E2F1_21310950_ChIP-Seq_MCF-7_Human1.71270875
68MTF2_20144788_ChIP-Seq_MESCs_Mouse1.68844890
69MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.68235194
70PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.68106876
71* REST_21632747_ChIP-Seq_MESCs_Mouse1.66338925
72MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.65474394
73CTBP1_25329375_ChIP-Seq_LNCAP_Human1.65243465
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.64314052
75EED_16625203_ChIP-ChIP_MESCs_Mouse1.62363574
76ER_23166858_ChIP-Seq_MCF-7_Human1.62067946
77PCGF2_27294783_Chip-Seq_ESCs_Mouse1.62013249
78ZFX_18555785_ChIP-Seq_MESCs_Mouse1.60699893
79SUZ12_27294783_Chip-Seq_ESCs_Mouse1.59754969
80EZH2_27294783_Chip-Seq_ESCs_Mouse1.57705541
81OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56527958
82SMAD4_21799915_ChIP-Seq_A2780_Human1.56182377
83ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.55931640
84JARID2_20075857_ChIP-Seq_MESCs_Mouse1.54339965
85EZH2_18974828_ChIP-Seq_MESCs_Mouse1.51323898
86RNF2_18974828_ChIP-Seq_MESCs_Mouse1.51323898
87CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.51249220
88VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.50453684
89FLI1_27457419_Chip-Seq_LIVER_Mouse1.50322165
90FUS_26573619_Chip-Seq_HEK293_Human1.49795466
91NANOG_18555785_Chip-Seq_ESCs_Mouse1.49782834
92TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.48107912
93MYC_18940864_ChIP-ChIP_HL60_Human1.44465718
94FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.44071856
95EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.44054904
96TAL1_26923725_Chip-Seq_HPCs_Mouse1.43399189
97SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42950899
98ELK1_22589737_ChIP-Seq_MCF10A_Human1.42912477
99CDX2_19796622_ChIP-Seq_MESCs_Mouse1.42776873
100ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.42201404
101SMAD3_21741376_ChIP-Seq_EPCs_Human1.42101601
102RNF2_27304074_Chip-Seq_NSC_Mouse1.41149485
103RNF2_27304074_Chip-Seq_ESCs_Mouse1.39985278
104SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.38862747
105P53_22387025_ChIP-Seq_ESCs_Mouse1.37551910
106NANOG_18555785_ChIP-Seq_MESCs_Mouse1.36936727
107KDM5A_27292631_Chip-Seq_BREAST_Human1.36625145
108SUZ12_18555785_Chip-Seq_ESCs_Mouse1.36510084
109DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.35311607
110SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.34859861
111TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.33449835
112PIAS1_25552417_ChIP-Seq_VCAP_Human1.32551999
113TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31717552
114SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31637924
115CMYC_18555785_Chip-Seq_ESCs_Mouse1.29230893
116UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29017910
117STAT3_18555785_Chip-Seq_ESCs_Mouse1.28616377
118DROSHA_22980978_ChIP-Seq_HELA_Human1.27679033
119AR_21572438_ChIP-Seq_LNCaP_Human1.27634987
120CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.26576632
121RBPJ_22232070_ChIP-Seq_NCS_Mouse1.25927476
122EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.25849515
123STAT3_23295773_ChIP-Seq_U87_Human1.23889424
124E2F1_18555785_Chip-Seq_ESCs_Mouse1.22840394
125AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22771925
126MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21890252
127E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.21091389
128POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.20703857
129HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.20491580
130KDM2B_26808549_Chip-Seq_REH_Human1.20474982
131P300_18555785_Chip-Seq_ESCs_Mouse1.20364316
132PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.20301671
133SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20041893
134* REST_18959480_ChIP-ChIP_MESCs_Mouse1.18350726
135TCF4_23295773_ChIP-Seq_U87_Human1.17599807
136RUNX1_27457419_Chip-Seq_LIVER_Mouse1.17481570
137NFE2_27457419_Chip-Seq_LIVER_Mouse1.17247659
138EZH2_27294783_Chip-Seq_NPCs_Mouse1.16571224
139PRDM14_20953172_ChIP-Seq_ESCs_Human1.15716898
140PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15502990
141IKZF1_21737484_ChIP-ChIP_HCT116_Human1.15200131
142SOX17_20123909_ChIP-Seq_XEN_Mouse1.15092429
143SOX2_18555785_Chip-Seq_ESCs_Mouse1.15042291
144AR_25329375_ChIP-Seq_VCAP_Human1.15003515
145CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.14930102
146TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13543547
147ERG_20887958_ChIP-Seq_HPC-7_Mouse1.13508226
148EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.13377928
149TFEB_21752829_ChIP-Seq_HELA_Human1.11252052
150RUNX2_22187159_ChIP-Seq_PCA_Human1.10047090
151ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.08986883
152NMYC_18555785_Chip-Seq_ESCs_Mouse1.08833519
153RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.07895676
154YY1_21170310_ChIP-Seq_MESCs_Mouse1.07787369
155CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.07261579
156OCT4_18555785_Chip-Seq_ESCs_Mouse1.06149588
157KLF4_18555785_Chip-Seq_ESCs_Mouse1.06079801
158TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04976538
159POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04976538
160TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04960724
161RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04875921
162TP53_18474530_ChIP-ChIP_U2OS_Human1.04804280
163BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04476837
164IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03067873
165CBP_20019798_ChIP-Seq_JUKART_Human1.03067873
166CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.02892426
167CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.02568547
168CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02527384
169NANOG_19829295_ChIP-Seq_ESCs_Human1.01463982
170SOX2_19829295_ChIP-Seq_ESCs_Human1.01463982
171PU1_27457419_Chip-Seq_LIVER_Mouse1.01255986
172NANOG_16153702_ChIP-ChIP_HESCs_Human1.00718522
173SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.95125283
174SALL1_21062744_ChIP-ChIP_HESCs_Human0.94052033
175CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91635772
176POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.91446973
177* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.87621232
178CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.84924065
179* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.84880146
180EWS_26573619_Chip-Seq_HEK293_Human0.84049438
181KLF4_18555785_ChIP-Seq_MESCs_Mouse0.83964517
182SOX2_18555785_ChIP-Seq_MESCs_Mouse0.83648940
183SOX2_16153702_ChIP-ChIP_HESCs_Human0.79031476
184NOTCH1_21737748_ChIP-Seq_TLL_Human0.77900868
185POU5F1_16153702_ChIP-ChIP_HESCs_Human0.77753925
186ELF5_23300383_ChIP-Seq_T47D_Human0.77272732
187ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.75415808
188CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.75201476
189ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.74436191
190IRF1_19129219_ChIP-ChIP_H3396_Human0.74015815
191SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.73031257
192EOMES_21245162_ChIP-Seq_HESCs_Human0.72852325
193TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.71548723
194GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.70060956
195CHD1_26751641_Chip-Seq_LNCaP_Human0.69972452
196NANOG_21062744_ChIP-ChIP_HESCs_Human0.69463134
197DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.67552145
198NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.67177863

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.02075641
2MP0008058_abnormal_DNA_repair3.81517513
3MP0010094_abnormal_chromosome_stability3.57978913
4MP0004957_abnormal_blastocyst_morpholog3.40042447
5MP0003111_abnormal_nucleus_morphology3.28956979
6MP0001529_abnormal_vocalization3.19423638
7MP0003806_abnormal_nucleotide_metabolis3.16622332
8MP0001986_abnormal_taste_sensitivity3.09855071
9MP0003693_abnormal_embryo_hatching3.08955531
10MP0005423_abnormal_somatic_nervous3.08010852
11MP0004270_analgesia2.92656393
12MP0003941_abnormal_skin_development2.88732051
13MP0008932_abnormal_embryonic_tissue2.85579435
14MP0008007_abnormal_cellular_replicative2.85377145
15MP0005410_abnormal_fertilization2.84174346
16MP0003077_abnormal_cell_cycle2.77946387
17MP0008057_abnormal_DNA_replication2.54022112
18MP0001905_abnormal_dopamine_level2.50207269
19MP0002938_white_spotting2.44156612
20MP0001486_abnormal_startle_reflex2.43587102
21MP0001188_hyperpigmentation2.42700082
22MP0009046_muscle_twitch2.40047644
23MP0002272_abnormal_nervous_system2.39410245
24MP0000920_abnormal_myelination2.35306331
25MP0002735_abnormal_chemical_nociception2.34167134
26MP0004859_abnormal_synaptic_plasticity2.34150595
27MP0002064_seizures2.33634901
28MP0009745_abnormal_behavioral_response2.33582852
29MP0006036_abnormal_mitochondrial_physio2.32930811
30MP0003635_abnormal_synaptic_transmissio2.29894634
31MP0001968_abnormal_touch/_nociception2.29798387
32MP0005645_abnormal_hypothalamus_physiol2.24949345
33MP0002736_abnormal_nociception_after2.14997303
34MP0002734_abnormal_mechanical_nocicepti2.11821520
35MP0002572_abnormal_emotion/affect_behav2.09978189
36MP0004142_abnormal_muscle_tone2.01807917
37MP0003718_maternal_effect2.01425406
38MP0004742_abnormal_vestibular_system2.01296666
39MP0010234_abnormal_vibrissa_follicle1.99040681
40MP0010386_abnormal_urinary_bladder1.93132079
41MP0002063_abnormal_learning/memory/cond1.87110709
42MP0005409_darkened_coat_color1.84004442
43MP0005646_abnormal_pituitary_gland1.83834956
44MP0000566_synostosis1.81810289
45MP0003136_yellow_coat_color1.79141133
46MP0003283_abnormal_digestive_organ1.78819713
47MP0001970_abnormal_pain_threshold1.77577662
48MP0006276_abnormal_autonomic_nervous1.75481805
49MP0005171_absent_coat_pigmentation1.75343353
50MP0006035_abnormal_mitochondrial_morpho1.75105088
51MP0003890_abnormal_embryonic-extraembry1.68631814
52MP0003011_delayed_dark_adaptation1.66822630
53* MP0002067_abnormal_sensory_capabilities1.64204070
54MP0001984_abnormal_olfaction1.63670946
55MP0003786_premature_aging1.62950418
56MP0001485_abnormal_pinna_reflex1.62894965
57MP0001501_abnormal_sleep_pattern1.60640966
58MP0000778_abnormal_nervous_system1.60462953
59MP0004885_abnormal_endolymph1.60298625
60MP0003123_paternal_imprinting1.59678332
61MP0001730_embryonic_growth_arrest1.59573384
62MP0001440_abnormal_grooming_behavior1.59443448
63MP0003329_amyloid_beta_deposits1.59229352
64MP0009379_abnormal_foot_pigmentation1.58973357
65MP0004924_abnormal_behavior1.58219465
66MP0005386_behavior/neurological_phenoty1.58219465
67MP0002733_abnormal_thermal_nociception1.58191605
68MP0000015_abnormal_ear_pigmentation1.57143229
69MP0001502_abnormal_circadian_rhythm1.55131545
70MP0003186_abnormal_redox_activity1.49802416
71MP0001697_abnormal_embryo_size1.48338220
72MP0002233_abnormal_nose_morphology1.47299263
73MP0008877_abnormal_DNA_methylation1.46325449
74MP0008789_abnormal_olfactory_epithelium1.44789150
75MP0000350_abnormal_cell_proliferation1.41993356
76MP0002876_abnormal_thyroid_physiology1.41912006
77MP0001293_anophthalmia1.40693185
78MP0004381_abnormal_hair_follicle1.40210263
79MP0005408_hypopigmentation1.39902658
80MP0003121_genomic_imprinting1.35712362
81* MP0002229_neurodegeneration1.32535328
82MP0002234_abnormal_pharynx_morphology1.32052608
83MP0002557_abnormal_social/conspecific_i1.30383412
84MP0005551_abnormal_eye_electrophysiolog1.30247223
85MP0001963_abnormal_hearing_physiology1.27092397
86MP0003937_abnormal_limbs/digits/tail_de1.26835543
87MP0004147_increased_porphyrin_level1.24719342
88MP0003634_abnormal_glial_cell1.21609054
89MP0002184_abnormal_innervation1.20476211
90MP0000372_irregular_coat_pigmentation1.18693024
91MP0002084_abnormal_developmental_patter1.18555174
92MP0001286_abnormal_eye_development1.18197291
93MP0002160_abnormal_reproductive_system1.17921070
94MP0003183_abnormal_peptide_metabolism1.16513776
95MP0010307_abnormal_tumor_latency1.16258243
96MP0008260_abnormal_autophagy1.15725561
97MP0003690_abnormal_glial_cell1.15396141
98MP0005380_embryogenesis_phenotype1.14896933
99MP0001672_abnormal_embryogenesis/_devel1.14896933
100MP0003119_abnormal_digestive_system1.14143222
101MP0002102_abnormal_ear_morphology1.13248148
102MP0010678_abnormal_skin_adnexa1.12467224
103MP0005075_abnormal_melanosome_morpholog1.12415463
104MP0002080_prenatal_lethality1.11824368
105* MP0002882_abnormal_neuron_morphology1.11119162
106MP0010352_gastrointestinal_tract_polyps1.10281357
107MP0002085_abnormal_embryonic_tissue1.08981196
108* MP0008569_lethality_at_weaning1.07224870
109MP0002095_abnormal_skin_pigmentation1.06641391
110MP0002822_catalepsy1.06544438
111* MP0002066_abnormal_motor_capabilities/c1.03767147
112MP0004043_abnormal_pH_regulation1.03391008
113MP0006292_abnormal_olfactory_placode1.03186313
114MP0003631_nervous_system_phenotype1.02385106
115MP0003633_abnormal_nervous_system1.01914213
116MP0005394_taste/olfaction_phenotype1.01614413
117MP0005499_abnormal_olfactory_system1.01614413
118MP0000955_abnormal_spinal_cord1.01110153
119MP0002282_abnormal_trachea_morphology1.00914241
120MP0000026_abnormal_inner_ear1.00809651
121MP0003984_embryonic_growth_retardation1.00696677
122MP0003698_abnormal_male_reproductive1.00473434
123MP0002638_abnormal_pupillary_reflex0.99627346
124MP0003950_abnormal_plasma_membrane0.99464663
125MP0005379_endocrine/exocrine_gland_phen0.97931838
126MP0002088_abnormal_embryonic_growth/wei0.97566210
127MP0002210_abnormal_sex_determination0.96373914
128MP0000358_abnormal_cell_content/0.96173693
129MP0001929_abnormal_gametogenesis0.94820612
130MP0003943_abnormal_hepatobiliary_system0.94096945
131MP0000313_abnormal_cell_death0.92888068
132MP0004233_abnormal_muscle_weight0.92811497
133MP0000762_abnormal_tongue_morphology0.92763841
134MP0001664_abnormal_digestion0.92655549
135MP0006072_abnormal_retinal_apoptosis0.91988158
136MP0003567_abnormal_fetal_cardiomyocyte0.91590507
137MP0005391_vision/eye_phenotype0.90889366
138MP0003879_abnormal_hair_cell0.90731112
139MP0002752_abnormal_somatic_nervous0.88960290
140MP0003632_abnormal_nervous_system0.87652197
141MP0004197_abnormal_fetal_growth/weight/0.86137370
142MP0002090_abnormal_vision0.85556239
143MP0002148_abnormal_hypersensitivity_rea0.84971202
144MP0003122_maternal_imprinting0.84564683
145MP0002697_abnormal_eye_size0.83346694
146MP0001661_extended_life_span0.82909127
147MP0000749_muscle_degeneration0.82269393
148MP0005174_abnormal_tail_pigmentation0.82254444
149MP0002751_abnormal_autonomic_nervous0.81364602
150MP0005367_renal/urinary_system_phenotyp0.80610780
151MP0000516_abnormal_urinary_system0.80610780
152MP0003787_abnormal_imprinting0.80245413
153MP0001145_abnormal_male_reproductive0.80137473
154MP0000631_abnormal_neuroendocrine_gland0.79995457
155MP0005058_abnormal_lysosome_morphology0.78848914
156MP0000653_abnormal_sex_gland0.78319476
157MP0003724_increased_susceptibility_to0.77007822
158MP0000579_abnormal_nail_morphology0.76531265
159MP0005084_abnormal_gallbladder_morpholo0.75789411
160MP0004811_abnormal_neuron_physiology0.75599711
161MP0005220_abnormal_exocrine_pancreas0.75452966
162MP0002086_abnormal_extraembryonic_tissu0.75242928
163MP0001727_abnormal_embryo_implantation0.75145927
164MP0002163_abnormal_gland_morphology0.74850585
165MP0004134_abnormal_chest_morphology0.73238326
166MP0000377_abnormal_hair_follicle0.72956823
167MP0009780_abnormal_chondrocyte_physiolo0.72781303
168MP0003755_abnormal_palate_morphology0.71894708
169MP0000604_amyloidosis0.71011268
170MP0009697_abnormal_copulation0.70224998
171MP0002909_abnormal_adrenal_gland0.70093925
172MP0005389_reproductive_system_phenotype0.69438892
173MP0005501_abnormal_skin_physiology0.67337625
174MP0005384_cellular_phenotype0.67276398
175MP0003385_abnormal_body_wall0.66492062
176MP0002069_abnormal_eating/drinking_beha0.66182076
177MP0000538_abnormal_urinary_bladder0.65868612
178MP0004858_abnormal_nervous_system0.63780167
179MP0001177_atelectasis0.62822856
180MP0005451_abnormal_body_composition0.61124023
181MP0005253_abnormal_eye_physiology0.59674561
182MP0005195_abnormal_posterior_eye0.58038503
183MP0005535_abnormal_body_temperature0.55283303
184* MP0002152_abnormal_brain_morphology0.54986443

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)5.01704506
2Absent/shortened dynein arms (HP:0200106)5.01704506
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.39469461
4Neurofibrillary tangles (HP:0002185)3.91502881
5Abnormal ciliary motility (HP:0012262)3.78255516
6Abnormal respiratory motile cilium physiology (HP:0012261)3.70840980
7Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.64697297
8Degeneration of the lateral corticospinal tracts (HP:0002314)3.64697297
9Abnormal respiratory motile cilium morphology (HP:0005938)3.50324316
10Abnormal respiratory epithelium morphology (HP:0012253)3.50324316
11Retinal dysplasia (HP:0007973)3.49545064
12Parakeratosis (HP:0001036)3.48940960
13Hepatic necrosis (HP:0002605)3.48684791
143-Methylglutaconic aciduria (HP:0003535)3.43287241
15Cerebral edema (HP:0002181)3.42245569
16Focal motor seizures (HP:0011153)3.41651226
17Medial flaring of the eyebrow (HP:0010747)3.41573938
18Lipid accumulation in hepatocytes (HP:0006561)3.33836387
19Gait imbalance (HP:0002141)3.27611367
20Hyperventilation (HP:0002883)3.14006621
21Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.13503669
22Congenital primary aphakia (HP:0007707)3.00916703
23Microvesicular hepatic steatosis (HP:0001414)2.86929996
24Rhinitis (HP:0012384)2.81748319
25Nephrogenic diabetes insipidus (HP:0009806)2.81428167
26Epileptic encephalopathy (HP:0200134)2.81415594
27Increased serum lactate (HP:0002151)2.77199680
28Exercise intolerance (HP:0003546)2.76650660
29Respiratory failure (HP:0002878)2.71273348
30Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.67830111
31Decreased activity of mitochondrial respiratory chain (HP:0008972)2.67830111
32Degeneration of anterior horn cells (HP:0002398)2.64369591
33Abnormality of the anterior horn cell (HP:0006802)2.64369591
34Vaginal atresia (HP:0000148)2.63416729
35Hypoglycemic coma (HP:0001325)2.60967371
36Supranuclear gaze palsy (HP:0000605)2.60169065
37Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.59631931
38Progressive inability to walk (HP:0002505)2.58975390
39Macrocytic anemia (HP:0001972)2.56842898
40Abnormality of methionine metabolism (HP:0010901)2.54932329
41Patchy hypopigmentation of hair (HP:0011365)2.54267523
42Renal Fanconi syndrome (HP:0001994)2.51981128
43Abnormality of the corticospinal tract (HP:0002492)2.51850728
44Genital tract atresia (HP:0001827)2.51821481
45Lactic acidosis (HP:0003128)2.51329878
46White forelock (HP:0002211)2.47842815
47Cerebral inclusion bodies (HP:0100314)2.47158458
48Myokymia (HP:0002411)2.46294696
49Acute necrotizing encephalopathy (HP:0006965)2.44702285
50Abnormal lung lobation (HP:0002101)2.43472672
51Limb dystonia (HP:0002451)2.41846051
52Mitochondrial inheritance (HP:0001427)2.38468484
53Sparse eyelashes (HP:0000653)2.37678220
54Neoplasm of the adrenal gland (HP:0100631)2.32346929
55Increased intramyocellular lipid droplets (HP:0012240)2.31823649
56Cerebral hypomyelination (HP:0006808)2.30153324
57Hyperinsulinemic hypoglycemia (HP:0000825)2.28846355
58Abnormality of chromosome stability (HP:0003220)2.27275788
59Febrile seizures (HP:0002373)2.27150266
60Thickened helices (HP:0000391)2.25521307
61Inability to walk (HP:0002540)2.25126577
62Aplasia/Hypoplasia of the lens (HP:0008063)2.24756546
63Poor coordination (HP:0002370)2.23650378
64Sensory axonal neuropathy (HP:0003390)2.22324594
65Abnormality of aspartate family amino acid metabolism (HP:0010899)2.21121993
66CNS demyelination (HP:0007305)2.20336735
67Oral leukoplakia (HP:0002745)2.19777382
68Secondary amenorrhea (HP:0000869)2.19040315
69Hypothermia (HP:0002045)2.17098516
70Type I transferrin isoform profile (HP:0003642)2.17005135
71Broad-based gait (HP:0002136)2.16234449
72Dry hair (HP:0011359)2.15488505
73Peripheral hypomyelination (HP:0007182)2.15360798
74Abnormality of cells of the erythroid lineage (HP:0012130)2.12271641
75Pheochromocytoma (HP:0002666)2.12102140
76Reticulocytopenia (HP:0001896)2.11925465
77Abnormality of renal resorption (HP:0011038)2.11784250
78Chromsome breakage (HP:0040012)2.11374519
79Lethargy (HP:0001254)2.10941506
80Akinesia (HP:0002304)2.09835888
81Spastic gait (HP:0002064)2.09622374
82Generalized aminoaciduria (HP:0002909)2.07741004
83Abnormal mitochondria in muscle tissue (HP:0008316)2.07118335
84Progressive macrocephaly (HP:0004481)2.05267178
85Abnormality of the preputium (HP:0100587)2.03826393
86Gaze-evoked nystagmus (HP:0000640)2.03271405
87Nephronophthisis (HP:0000090)2.03269722
88Polyphagia (HP:0002591)2.02753471
89Hepatocellular necrosis (HP:0001404)2.02460276
90Papillary thyroid carcinoma (HP:0002895)2.01918103
91Neuroendocrine neoplasm (HP:0100634)1.99784552
92True hermaphroditism (HP:0010459)1.99611289
93Chromosomal breakage induced by crosslinking agents (HP:0003221)1.98324078
94Congenital ichthyosiform erythroderma (HP:0007431)1.97666967
95Megaloblastic anemia (HP:0001889)1.95767157
96Thyroid carcinoma (HP:0002890)1.94144428
97Premature ovarian failure (HP:0008209)1.93603979
98Birth length less than 3rd percentile (HP:0003561)1.93532409
99Pancreatic islet-cell hyperplasia (HP:0004510)1.93436234
100Abnormality of the labia minora (HP:0012880)1.93263295
101* Abnormal hair whorl (HP:0010721)1.93038358
102Leukodystrophy (HP:0002415)1.92961448
103Protruding tongue (HP:0010808)1.92343406
104Abnormal number of erythroid precursors (HP:0012131)1.92266970
105Atonic seizures (HP:0010819)1.92124429
106Meckel diverticulum (HP:0002245)1.91806608
107Prostate neoplasm (HP:0100787)1.91260822
108Aplasia involving bones of the extremities (HP:0009825)1.91254384
109Aplasia involving bones of the upper limbs (HP:0009823)1.91254384
110Aplasia of the phalanges of the hand (HP:0009802)1.91254384
111Specific learning disability (HP:0001328)1.91106588
112Type II lissencephaly (HP:0007260)1.91055898
113Optic disc pallor (HP:0000543)1.91040272
114Renal cortical cysts (HP:0000803)1.90959568
115Rhabdomyosarcoma (HP:0002859)1.90771064
116Multiple enchondromatosis (HP:0005701)1.90493462
117Colon cancer (HP:0003003)1.90195030
118Increased CSF lactate (HP:0002490)1.89093785
119Aplastic anemia (HP:0001915)1.88637872
120Acute encephalopathy (HP:0006846)1.88240113
121Exertional dyspnea (HP:0002875)1.88103289
122CNS hypomyelination (HP:0003429)1.87769189
123Onion bulb formation (HP:0003383)1.87573703
124Widely spaced teeth (HP:0000687)1.87362322
125Congenital sensorineural hearing impairment (HP:0008527)1.85297155
126Congenital, generalized hypertrichosis (HP:0004540)1.84550944
127Dysmetria (HP:0001310)1.84389742
128Reduced antithrombin III activity (HP:0001976)1.83618475
129Facial cleft (HP:0002006)1.83499266
130Median cleft lip (HP:0000161)1.82915104
131Hypoplastic pelvis (HP:0008839)1.82889150
132Blue irides (HP:0000635)1.82516213
133Absent septum pellucidum (HP:0001331)1.81459735
134Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.81085158
135Severe visual impairment (HP:0001141)1.80670053
136Abnormality of placental membranes (HP:0011409)1.80290130
137Amniotic constriction ring (HP:0009775)1.80290130
138Increased serum pyruvate (HP:0003542)1.80129254
139Abnormality of glycolysis (HP:0004366)1.80129254
140Abnormal biliary tract physiology (HP:0012439)1.79916960
141Bile duct proliferation (HP:0001408)1.79916960
142X-linked dominant inheritance (HP:0001423)1.78018063
143Methylmalonic acidemia (HP:0002912)1.77162687
144Abnormality of incisor morphology (HP:0011063)1.77152953
145Hypoglycemic seizures (HP:0002173)1.76340465
146Abnormality of molar (HP:0011077)1.76298883
147Abnormality of molar morphology (HP:0011070)1.76298883
148Alacrima (HP:0000522)1.76245440
149Hyperglycinuria (HP:0003108)1.76203709
150Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.75869757
151Vertebral hypoplasia (HP:0008417)1.75869757
152Aplasia/Hypoplasia of the sacrum (HP:0008517)1.75779050
153Poor speech (HP:0002465)1.75730489
154Increased muscle lipid content (HP:0009058)1.74488973
155Pili torti (HP:0003777)1.74380247
156Focal seizures (HP:0007359)1.74319344
157Ankle clonus (HP:0011448)1.74196784
158Abnormality of permanent molar morphology (HP:0011071)1.73297893
159Abnormality of the dental root (HP:0006486)1.73297893
160Taurodontia (HP:0000679)1.73297893
161Septo-optic dysplasia (HP:0100842)1.72850782
162Absent speech (HP:0001344)1.72643032
163Ketoacidosis (HP:0001993)1.72601166
164Abnormality of endocrine pancreas physiology (HP:0012093)1.72429376
165Abnormality of the pancreatic islet cells (HP:0006476)1.72429376
166Proximal tubulopathy (HP:0000114)1.72380649
167Abnormality of urine glucose concentration (HP:0011016)1.72050063
168Glycosuria (HP:0003076)1.72050063
169Abnormality of the ileum (HP:0001549)1.71852755
170Medulloblastoma (HP:0002885)1.71692269
171Gonadotropin excess (HP:0000837)1.71672026
172Increased hepatocellular lipid droplets (HP:0006565)1.71657362
173Respiratory difficulties (HP:0002880)1.71027965
174Postnatal microcephaly (HP:0005484)1.70315000
175Esotropia (HP:0000565)1.68458977
176Progressive cerebellar ataxia (HP:0002073)1.67897778
177Mutism (HP:0002300)1.67338409
178Hypomagnesemia (HP:0002917)1.66983771
179Metabolic alkalosis (HP:0200114)1.63769549
180Infertility (HP:0000789)1.62482182
181Abnormality of the dental pulp (HP:0006479)1.62274200
182Abnormality of the renal medulla (HP:0100957)1.61740667
183Optic nerve hypoplasia (HP:0000609)1.61542506

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.17171855
2VRK23.88238479
3STK393.58690358
4EIF2AK13.33308104
5TNIK3.15672071
6BUB13.07362727
7EIF2AK32.92428499
8OXSR12.80689018
9CDC72.75820148
10NEK12.52602107
11TTK2.49004436
12PRPF4B2.42554289
13SIK32.40357507
14CDK192.36669273
15WEE12.32713772
16TSSK62.24342888
17SRPK12.21082672
18VRK12.19712235
19BCR2.11677075
20PLK32.08774249
21MAP2K72.08393690
22TAF11.95733756
23MUSK1.95094884
24MAPKAPK51.86463981
25STK161.85386688
26WNK41.84431193
27PASK1.84197410
28EPHA41.82912221
29MARK11.77385286
30NME21.70849415
31BRSK21.65310944
32BMPR21.64545056
33PKN11.63174975
34ADRBK21.60705136
35PLK41.58151205
36NUAK11.56790751
37MAP3K121.49057754
38PLK11.48184621
39SCYL21.39062989
40ALK1.37857370
41MAPK131.37788417
42NTRK21.34765434
43SGK4941.33708491
44SGK2231.33708491
45WNK11.33175574
46ARAF1.32929560
47NTRK31.32528092
48MAPK151.26098798
49NEK61.25192967
50ZAK1.23763067
51CSNK1G31.22135611
52EIF2AK21.20031951
53TRIM281.19907381
54CAMK2B1.19754253
55BRSK11.15915549
56BLK1.14339715
57GRK71.09543976
58UHMK11.09287005
59CLK11.06682454
60CSNK1G21.05461848
61MST1R1.05094209
62PRKCE1.02641448
63CSNK1A1L1.02575389
64MAP3K141.01675593
65CAMK2A1.01656841
66STK241.01368045
67DYRK21.01240802
68PNCK0.97616553
69AURKB0.97234187
70MST40.94828840
71YES10.94076699
72PLK20.92168715
73WNK30.90279045
74ATR0.88343661
75GRK50.87544486
76CSNK1G10.87301417
77PBK0.86239203
78STK38L0.86157674
79NME10.85617674
80ATM0.84826282
81CAMK2D0.84668662
82FGFR20.84566065
83LMTK20.84423906
84CDK50.83674180
85CDK30.81808608
86RPS6KB20.81683139
87PRKCQ0.80063750
88CHEK20.79993563
89PDK40.78463970
90PDK30.78463970
91EPHA20.77196206
92MINK10.76631979
93CAMK2G0.75672157
94ERBB30.73911059
95RIPK40.72323774
96MKNK20.71925019
97INSRR0.70763399
98DYRK1A0.70502366
99AURKA0.69478533
100FGR0.69033536
101CSNK2A20.69022852
102PINK10.68171251
103CDK70.67347378
104CHEK10.67346329
105LIMK10.66000335
106PDK20.65679539
107FES0.65310907
108NTRK10.65171825
109MAP3K130.65117740
110PTK2B0.64673603
111BRAF0.64648895
112TXK0.64326715
113STK40.64287504
114PIM20.64233275
115SGK20.63843777
116PAK40.63396049
117MAP3K40.61448055
118PRKCG0.60929082
119IRAK10.60631810
120IRAK20.59078383
121IRAK40.56509531
122CSNK2A10.55910887
123* BMPR1B0.54655884
124PHKG20.52989929
125PHKG10.52989929
126PAK60.52828655
127EPHB10.51906518
128LRRK20.51848801
129MAP3K90.50367466
130MET0.49955238
131ROCK20.49937581
132CSNK1E0.49450661
133PRKCH0.47968929
134PRKG10.47405953
135SYK0.46582026
136CDK180.45942352
137KIT0.45399459
138CDK10.43257494
139ADRBK10.42968529
140MARK20.42935460
141STK30.42043861
142DAPK20.41975622
143AKT20.41595910
144CDK80.40701027
145PAK30.40322460
146ERBB40.40071004
147CDK140.39956317
148RPS6KA40.39164931
149PRKDC0.39008820
150PRKCI0.37811073
151MKNK10.37757119
152CDK20.37587749
153ILK0.37534676
154BCKDK0.36772110
155CDK150.36575824
156FGFR10.34075933
157DYRK30.33678509
158AKT30.26831546
159ABL20.26194212
160NEK20.25589234
161RPS6KB10.25001612
162EGFR0.24727359

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.40712880
2Ribosome_Homo sapiens_hsa030103.03142823
3DNA replication_Homo sapiens_hsa030302.87630921
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.86508351
5Mismatch repair_Homo sapiens_hsa034302.82486480
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.81007967
7Oxidative phosphorylation_Homo sapiens_hsa001902.72968752
8Collecting duct acid secretion_Homo sapiens_hsa049662.69714229
9RNA polymerase_Homo sapiens_hsa030202.65722106
10Nicotine addiction_Homo sapiens_hsa050332.62504931
11Steroid biosynthesis_Homo sapiens_hsa001002.52568494
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.48967287
13Homologous recombination_Homo sapiens_hsa034402.42592403
14Protein export_Homo sapiens_hsa030602.35728398
15Synaptic vesicle cycle_Homo sapiens_hsa047212.24754331
16Non-homologous end-joining_Homo sapiens_hsa034502.23967187
17Spliceosome_Homo sapiens_hsa030402.23705425
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.20599551
19Ether lipid metabolism_Homo sapiens_hsa005652.17261597
20Serotonergic synapse_Homo sapiens_hsa047262.16631910
21Fatty acid elongation_Homo sapiens_hsa000622.16537487
22RNA transport_Homo sapiens_hsa030132.15446782
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.09726294
24Nucleotide excision repair_Homo sapiens_hsa034202.09175303
25Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.06641274
26Base excision repair_Homo sapiens_hsa034102.05915596
27GABAergic synapse_Homo sapiens_hsa047272.04531664
28SNARE interactions in vesicular transport_Homo sapiens_hsa041302.00374313
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.96640654
30Morphine addiction_Homo sapiens_hsa050321.94530962
31Vibrio cholerae infection_Homo sapiens_hsa051101.87099606
32One carbon pool by folate_Homo sapiens_hsa006701.85522860
33Taste transduction_Homo sapiens_hsa047421.84464785
34Parkinsons disease_Homo sapiens_hsa050121.83643854
35Sphingolipid metabolism_Homo sapiens_hsa006001.83054275
36Alzheimers disease_Homo sapiens_hsa050101.81931271
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.78406635
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.76932707
39Glutamatergic synapse_Homo sapiens_hsa047241.76801838
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.73746505
41Pyrimidine metabolism_Homo sapiens_hsa002401.71306417
42RNA degradation_Homo sapiens_hsa030181.69654785
43Rheumatoid arthritis_Homo sapiens_hsa053231.69255336
44Circadian entrainment_Homo sapiens_hsa047131.68695321
45Fanconi anemia pathway_Homo sapiens_hsa034601.64299103
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.55119050
47Cell cycle_Homo sapiens_hsa041101.50056136
48Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.48745886
49Pentose phosphate pathway_Homo sapiens_hsa000301.48039611
50Propanoate metabolism_Homo sapiens_hsa006401.45458107
51Carbon metabolism_Homo sapiens_hsa012001.41165316
52Huntingtons disease_Homo sapiens_hsa050161.33036330
53Amphetamine addiction_Homo sapiens_hsa050311.30402325
54Cocaine addiction_Homo sapiens_hsa050301.29987310
55Olfactory transduction_Homo sapiens_hsa047401.28235175
56Linoleic acid metabolism_Homo sapiens_hsa005911.27928755
572-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.26430070
58Phototransduction_Homo sapiens_hsa047441.25452873
59Phagosome_Homo sapiens_hsa041451.22732847
60Insulin secretion_Homo sapiens_hsa049111.21926072
61Axon guidance_Homo sapiens_hsa043601.20697174
62Biosynthesis of amino acids_Homo sapiens_hsa012301.19806355
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.19673303
64Dopaminergic synapse_Homo sapiens_hsa047281.18836482
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.18236892
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.16745691
67Sulfur metabolism_Homo sapiens_hsa009201.15450665
68Folate biosynthesis_Homo sapiens_hsa007901.13593795
69Arachidonic acid metabolism_Homo sapiens_hsa005901.12809951
70Cysteine and methionine metabolism_Homo sapiens_hsa002701.11788928
71Glutathione metabolism_Homo sapiens_hsa004801.10609724
72Cholinergic synapse_Homo sapiens_hsa047251.08755348
73Purine metabolism_Homo sapiens_hsa002301.07765439
74Calcium signaling pathway_Homo sapiens_hsa040201.07532715
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.06644998
76Long-term depression_Homo sapiens_hsa047301.04073227
77Pentose and glucuronate interconversions_Homo sapiens_hsa000401.03999619
78Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.02060160
79Maturity onset diabetes of the young_Homo sapiens_hsa049501.00825135
80mRNA surveillance pathway_Homo sapiens_hsa030150.99164803
81Salivary secretion_Homo sapiens_hsa049700.97122608
82Renin secretion_Homo sapiens_hsa049240.97068266
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.95425308
84Peroxisome_Homo sapiens_hsa041460.93453977
85Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93012692
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91912211
87Autoimmune thyroid disease_Homo sapiens_hsa053200.90897645
88Cardiac muscle contraction_Homo sapiens_hsa042600.89772530
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.89556294
90Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.87867464
91Fatty acid metabolism_Homo sapiens_hsa012120.87718190
92Lysosome_Homo sapiens_hsa041420.86301084
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.85728782
94Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.81398719
95Histidine metabolism_Homo sapiens_hsa003400.80946146
96Selenocompound metabolism_Homo sapiens_hsa004500.80594565
97Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79437334
98Regulation of autophagy_Homo sapiens_hsa041400.77168003
99Oocyte meiosis_Homo sapiens_hsa041140.76870053
100Fatty acid degradation_Homo sapiens_hsa000710.72808906
101Long-term potentiation_Homo sapiens_hsa047200.72471534
102Ras signaling pathway_Homo sapiens_hsa040140.70951524
103Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69164015
104Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68767558
105Type I diabetes mellitus_Homo sapiens_hsa049400.68146958
106Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66859354
107Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.65860764
108Vascular smooth muscle contraction_Homo sapiens_hsa042700.65593986
109Other glycan degradation_Homo sapiens_hsa005110.61472419
110p53 signaling pathway_Homo sapiens_hsa041150.61399322
111Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61166132
112Vitamin digestion and absorption_Homo sapiens_hsa049770.60967518
113Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60925874
114Pancreatic secretion_Homo sapiens_hsa049720.59536898
115Gastric acid secretion_Homo sapiens_hsa049710.58673409
116Allograft rejection_Homo sapiens_hsa053300.57361133
117cAMP signaling pathway_Homo sapiens_hsa040240.56522592
118Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55614939
119Thyroid cancer_Homo sapiens_hsa052160.54002950
120Vitamin B6 metabolism_Homo sapiens_hsa007500.53905923
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.53031628
122Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52663142
123Aldosterone synthesis and secretion_Homo sapiens_hsa049250.52334838
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.50325853
125Ovarian steroidogenesis_Homo sapiens_hsa049130.49672905
126Drug metabolism - other enzymes_Homo sapiens_hsa009830.49643729
127Asthma_Homo sapiens_hsa053100.45951066
128beta-Alanine metabolism_Homo sapiens_hsa004100.42827393
129Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.41238031
130ErbB signaling pathway_Homo sapiens_hsa040120.39588912
131Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38419325
132African trypanosomiasis_Homo sapiens_hsa051430.37606267
133Oxytocin signaling pathway_Homo sapiens_hsa049210.37461124
134Metabolic pathways_Homo sapiens_hsa011000.36986591
135Carbohydrate digestion and absorption_Homo sapiens_hsa049730.34831262
136Inositol phosphate metabolism_Homo sapiens_hsa005620.34620735
137Pyruvate metabolism_Homo sapiens_hsa006200.34525360
138Circadian rhythm_Homo sapiens_hsa047100.33516014
139Dorso-ventral axis formation_Homo sapiens_hsa043200.32963133
140Mineral absorption_Homo sapiens_hsa049780.32578184
141Nitrogen metabolism_Homo sapiens_hsa009100.32089288
142Butanoate metabolism_Homo sapiens_hsa006500.31449015
143Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.31242736
144Basal transcription factors_Homo sapiens_hsa030220.30090068
145Epstein-Barr virus infection_Homo sapiens_hsa051690.28514877
146Gap junction_Homo sapiens_hsa045400.28035506
147Malaria_Homo sapiens_hsa051440.27951483
148MAPK signaling pathway_Homo sapiens_hsa040100.27571583
149Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.27431219
150N-Glycan biosynthesis_Homo sapiens_hsa005100.27273846
151Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.27146792
152Chemokine signaling pathway_Homo sapiens_hsa040620.26966149
153cGMP-PKG signaling pathway_Homo sapiens_hsa040220.26898040
154Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.25796104
155Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25537290
156Phospholipase D signaling pathway_Homo sapiens_hsa040720.25116737
157Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.23541643
158Fructose and mannose metabolism_Homo sapiens_hsa000510.22263628
159Lysine degradation_Homo sapiens_hsa003100.20526933
160Galactose metabolism_Homo sapiens_hsa000520.19623657
161Chemical carcinogenesis_Homo sapiens_hsa052040.18033025
162Starch and sucrose metabolism_Homo sapiens_hsa005000.17607454
163Retinol metabolism_Homo sapiens_hsa008300.16026584
164Arginine and proline metabolism_Homo sapiens_hsa003300.12648899
165TGF-beta signaling pathway_Homo sapiens_hsa043500.12541476
166Tryptophan metabolism_Homo sapiens_hsa003800.11314931
167Tyrosine metabolism_Homo sapiens_hsa003500.06715342
168Systemic lupus erythematosus_Homo sapiens_hsa053220.05657364
169Fatty acid biosynthesis_Homo sapiens_hsa000610.05006505
170Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.04566562
171Wnt signaling pathway_Homo sapiens_hsa043100.03534400

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