STAM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the signal-transducing adaptor molecule family. These proteins mediate downstream signaling of cytokine receptors and also play a role in ER to Golgi trafficking by interacting with the coat protein II complex. The encoded protein also associates with hepatocyte growth factor-regulated substrate to form the endosomal sorting complex required for transport-0 (ESCRT-0), which sorts ubiquitinated membrane proteins to the ESCRT-1 complex for lysosomal degradation. Alternatively spliced transcript variants have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)5.52822548
2neuron cell-cell adhesion (GO:0007158)5.38153169
3presynaptic membrane organization (GO:0097090)5.17758260
4presynaptic membrane assembly (GO:0097105)5.14695634
5regulation of translational termination (GO:0006449)4.87302769
6axon ensheathment in central nervous system (GO:0032291)4.72379436
7central nervous system myelination (GO:0022010)4.72379436
8DNA replication checkpoint (GO:0000076)4.40817875
9nuclear pore complex assembly (GO:0051292)4.33111897
10regulation of meiosis I (GO:0060631)4.23634696
11chromatin remodeling at centromere (GO:0031055)4.20317930
12vocalization behavior (GO:0071625)4.11496586
13regulation of short-term neuronal synaptic plasticity (GO:0048172)4.08752480
14neuron recognition (GO:0008038)4.06040760
15paraxial mesoderm development (GO:0048339)4.04706851
16proteasome assembly (GO:0043248)4.02687943
17nuclear pore organization (GO:0006999)4.02211007
18axonal fasciculation (GO:0007413)3.99021206
19postsynaptic membrane organization (GO:0001941)3.95571166
20cullin deneddylation (GO:0010388)3.90833540
21ionotropic glutamate receptor signaling pathway (GO:0035235)3.88757135
22locomotory exploration behavior (GO:0035641)3.86616800
23protein localization to synapse (GO:0035418)3.83715936
24regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.79145236
25positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.78707788
26regulation of synaptic vesicle exocytosis (GO:2000300)3.77119999
27negative regulation of meiosis (GO:0045835)3.69802668
28glutamate receptor signaling pathway (GO:0007215)3.68533507
29positive regulation of synapse assembly (GO:0051965)3.67116200
30synaptic vesicle exocytosis (GO:0016079)3.65722900
31layer formation in cerebral cortex (GO:0021819)3.62380021
32DNA catabolic process, exonucleolytic (GO:0000738)3.61641768
33negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.54338389
34sister chromatid segregation (GO:0000819)3.53916884
35cerebellar granule cell differentiation (GO:0021707)3.52688387
36inner ear receptor cell development (GO:0060119)3.51524443
37cerebral cortex radially oriented cell migration (GO:0021799)3.50235390
38regulation of double-strand break repair via homologous recombination (GO:0010569)3.49712054
39protein deneddylation (GO:0000338)3.49282790
40neurotransmitter-gated ion channel clustering (GO:0072578)3.48722779
41microtubule depolymerization (GO:0007019)3.47418421
42CENP-A containing nucleosome assembly (GO:0034080)3.46969279
43protein K6-linked ubiquitination (GO:0085020)3.45816620
44protein localization to cilium (GO:0061512)3.45144737
45regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.42560515
46pore complex assembly (GO:0046931)3.42167072
47dendritic spine morphogenesis (GO:0060997)3.41070229
48somite rostral/caudal axis specification (GO:0032525)3.40764161
49synaptic transmission, glutamatergic (GO:0035249)3.39703104
50transmission of nerve impulse (GO:0019226)3.39118595
51neuron-neuron synaptic transmission (GO:0007270)3.35712815
52negative regulation of synaptic transmission, GABAergic (GO:0032229)3.35342645
53heterochromatin organization (GO:0070828)3.33515535
54regulation of glutamate receptor signaling pathway (GO:1900449)3.31724503
55synaptic vesicle maturation (GO:0016188)3.30403752
56glutamate secretion (GO:0014047)3.29953423
57regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.29326463
58regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.26471344
59dendrite morphogenesis (GO:0048813)3.25958998
60negative regulation of neurotransmitter transport (GO:0051589)3.24436938
61mitotic sister chromatid cohesion (GO:0007064)3.24192495
62regulation of synapse assembly (GO:0051963)3.22573216
63gamma-aminobutyric acid signaling pathway (GO:0007214)3.21345319
64regulation of centriole replication (GO:0046599)3.19781720
65behavioral response to ethanol (GO:0048149)3.18940162
66peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.18221279
67exploration behavior (GO:0035640)3.15066258
68RNA localization (GO:0006403)3.13700853
69regulation of centrosome duplication (GO:0010824)3.12508545
70neural tube formation (GO:0001841)3.12293378
71regulation of cAMP-dependent protein kinase activity (GO:2000479)3.12178401
72positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.11627832
73G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.10284766
74embryonic foregut morphogenesis (GO:0048617)3.09852335
75centriole replication (GO:0007099)3.09206943
76regulation of synaptic vesicle transport (GO:1902803)3.07259540
77synapse assembly (GO:0007416)3.06369320
78regulation of synaptic transmission, glutamatergic (GO:0051966)3.05787848
79regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.05163451
80membrane assembly (GO:0071709)3.04590497
81L-amino acid import (GO:0043092)3.04366066
82positive regulation of mRNA processing (GO:0050685)3.02872364
83dendrite development (GO:0016358)3.02564946
84prepulse inhibition (GO:0060134)3.02184073
85negative regulation of neurotransmitter secretion (GO:0046929)3.01667817
86limb bud formation (GO:0060174)3.01222226
87protein K11-linked ubiquitination (GO:0070979)3.00800252
88intraciliary transport (GO:0042073)3.00703955
89regulation of long-term neuronal synaptic plasticity (GO:0048169)2.99719352
90acrosome assembly (GO:0001675)2.98039830
91central nervous system projection neuron axonogenesis (GO:0021952)2.97961764
92glial cell proliferation (GO:0014009)2.97102815
93positive regulation of synapse maturation (GO:0090129)2.97015229
94histone exchange (GO:0043486)2.96458685
95ectoderm development (GO:0007398)2.94576442
96positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.93262365
97dermatan sulfate biosynthetic process (GO:0030208)2.91285926
98regulation of centrosome cycle (GO:0046605)2.90926488
99kinetochore organization (GO:0051383)2.90302155
100ribosome assembly (GO:0042255)2.89405014
101adenosine metabolic process (GO:0046085)2.87594345
102replication fork processing (GO:0031297)2.86889784
103termination of RNA polymerase I transcription (GO:0006363)2.86835895
104regulation of dendritic spine morphogenesis (GO:0061001)2.86716774
105ventricular system development (GO:0021591)2.86506287
106behavioral response to nicotine (GO:0035095)2.86083603
107pyrimidine nucleobase catabolic process (GO:0006208)2.85904885
108regulation of synapse organization (GO:0050807)2.85753429
109germ cell migration (GO:0008354)2.85593631
110regulation of excitatory postsynaptic membrane potential (GO:0060079)2.85109820
111regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.85092330
112DNA damage response, detection of DNA damage (GO:0042769)2.84918976
113neuronal action potential propagation (GO:0019227)2.84416115
114transcription elongation from RNA polymerase I promoter (GO:0006362)2.83944011
115myelination (GO:0042552)2.82962452
116long-term synaptic potentiation (GO:0060291)2.82815604
117negative regulation of DNA recombination (GO:0045910)2.82711287
118N-terminal protein amino acid acetylation (GO:0006474)2.81684150
119microtubule anchoring (GO:0034453)2.81503069
120microtubule polymerization or depolymerization (GO:0031109)2.80496225
121regulation of neuronal synaptic plasticity (GO:0048168)2.80488156
122auditory behavior (GO:0031223)2.80316046
123myelination in peripheral nervous system (GO:0022011)2.80263336
124peripheral nervous system axon ensheathment (GO:0032292)2.80263336
125protein neddylation (GO:0045116)2.79941484
126startle response (GO:0001964)2.79345910
127spindle checkpoint (GO:0031577)2.79096766
128amino acid import (GO:0043090)2.79061523
129neurotransmitter secretion (GO:0007269)2.78227999
130negative regulation of axon extension (GO:0030517)2.77355172
131synapse organization (GO:0050808)2.76823201
132phosphorelay signal transduction system (GO:0000160)2.75578960
133regulation of acyl-CoA biosynthetic process (GO:0050812)2.75114729
1347-methylguanosine mRNA capping (GO:0006370)2.73870934
135axon ensheathment (GO:0008366)2.73565855
136ensheathment of neurons (GO:0007272)2.73565855
137long-chain fatty acid biosynthetic process (GO:0042759)2.73422861
138regulation of postsynaptic membrane potential (GO:0060078)2.72857399
139metaphase plate congression (GO:0051310)2.72756041
140mitotic metaphase plate congression (GO:0007080)2.72503210
141regulation of synapse structural plasticity (GO:0051823)2.71758217
142mitotic spindle checkpoint (GO:0071174)2.71197508
143positive regulation of mRNA metabolic process (GO:1903313)2.70689441
144neurotransmitter uptake (GO:0001504)2.69505430
145innervation (GO:0060384)2.69499867
146synaptic vesicle docking involved in exocytosis (GO:0016081)2.68631490
147regulation of respiratory system process (GO:0044065)2.66923011
148cell migration in hindbrain (GO:0021535)2.66916266
149negative regulation of axonogenesis (GO:0050771)2.66411827
150neuronal ion channel clustering (GO:0045161)2.66194663
151protein prenylation (GO:0018342)2.65331636
152prenylation (GO:0097354)2.65331636
153attachment of spindle microtubules to kinetochore (GO:0008608)2.64662742
1547-methylguanosine RNA capping (GO:0009452)2.64013537
155RNA capping (GO:0036260)2.64013537
156regulation of cofactor metabolic process (GO:0051193)2.62127180
157regulation of coenzyme metabolic process (GO:0051196)2.62127180
158protein localization to kinetochore (GO:0034501)2.61649826
159mechanosensory behavior (GO:0007638)2.61072422
160stress granule assembly (GO:0034063)2.60780932
161adult walking behavior (GO:0007628)2.60169377
162regulation of synapse maturation (GO:0090128)2.60120208
163regulation of synaptic transmission, GABAergic (GO:0032228)2.59359285
164double-strand break repair via homologous recombination (GO:0000724)2.57831322
165negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.57102397
166recombinational repair (GO:0000725)2.56999246
167kinetochore assembly (GO:0051382)2.56718428
168resolution of meiotic recombination intermediates (GO:0000712)2.56590362
169regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.56475798
170negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.56144371
171DNA replication-independent nucleosome assembly (GO:0006336)2.55661989
172DNA replication-independent nucleosome organization (GO:0034724)2.55661989
173learning (GO:0007612)2.55569956
174hippocampus development (GO:0021766)2.55027440
175striatum development (GO:0021756)2.54833595
176regulation of sulfur metabolic process (GO:0042762)2.54757837
177central nervous system neuron axonogenesis (GO:0021955)2.54517064
178negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.54047827
179negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.54047827
180negative regulation of mitotic sister chromatid segregation (GO:0033048)2.54047827
181negative regulation of mitotic sister chromatid separation (GO:2000816)2.54047827
182negative regulation of sister chromatid segregation (GO:0033046)2.54047827
183histone H2A acetylation (GO:0043968)2.53863421
184regulation of dendritic spine development (GO:0060998)2.53844423
185neurotransmitter transport (GO:0006836)2.53559464
186regulation of neurotransmitter secretion (GO:0046928)2.53481827
187dermatan sulfate metabolic process (GO:0030205)2.53415200
188negative regulation of mRNA processing (GO:0050686)2.53265426
189membrane hyperpolarization (GO:0060081)2.52766489
190transcription initiation from RNA polymerase I promoter (GO:0006361)2.52355803
191spindle assembly checkpoint (GO:0071173)2.49682020
192peptidyl-histidine modification (GO:0018202)2.49660808
193DNA topological change (GO:0006265)2.49440206
194negative regulation of meiotic cell cycle (GO:0051447)2.48553936
195chromosome segregation (GO:0007059)2.46574860
196mitotic spindle assembly checkpoint (GO:0007094)2.45860448
197retina vasculature morphogenesis in camera-type eye (GO:0061299)2.45833374
198positive regulation of DNA repair (GO:0045739)2.45560225
199regulation of mitotic sister chromatid segregation (GO:0033047)2.42848319

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.09050344
2GBX2_23144817_ChIP-Seq_PC3_Human3.87781232
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.82005095
4* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.45519256
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.22411597
6ELK1_19687146_ChIP-ChIP_HELA_Human2.95355832
7E2F7_22180533_ChIP-Seq_HELA_Human2.93195309
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.71866512
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.69906224
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.68393178
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.60154750
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.52914799
13AR_21572438_ChIP-Seq_LNCaP_Human2.48926656
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.47506826
15TAF15_26573619_Chip-Seq_HEK293_Human2.41679958
16* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.38457217
17EZH2_18974828_ChIP-Seq_MESCs_Mouse2.38039105
18RNF2_18974828_ChIP-Seq_MESCs_Mouse2.38039105
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.34874961
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.31051749
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.29299040
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.26216073
23EZH2_27304074_Chip-Seq_ESCs_Mouse2.26181678
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.24971330
25POU3F2_20337985_ChIP-ChIP_501MEL_Human2.22535664
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.20461952
27JARID2_20075857_ChIP-Seq_MESCs_Mouse2.17964980
28* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.15913549
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.15615570
30FLI1_27457419_Chip-Seq_LIVER_Mouse2.14992675
31RBPJ_22232070_ChIP-Seq_NCS_Mouse2.12788943
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.12520554
33FUS_26573619_Chip-Seq_HEK293_Human2.11577859
34HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.10075076
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.04466018
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.04133618
37* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.01991673
38MTF2_20144788_ChIP-Seq_MESCs_Mouse1.99954868
39P300_19829295_ChIP-Seq_ESCs_Human1.99049290
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.96934179
41* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.94123701
42PADI4_21655091_ChIP-ChIP_MCF-7_Human1.93055364
43* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87724897
44SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.84868555
45RNF2_27304074_Chip-Seq_ESCs_Mouse1.83321165
46* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.79359946
47* VDR_23849224_ChIP-Seq_CD4+_Human1.78809412
48EZH2_27294783_Chip-Seq_ESCs_Mouse1.78557587
49PIAS1_25552417_ChIP-Seq_VCAP_Human1.77432547
50SMAD4_21799915_ChIP-Seq_A2780_Human1.77200058
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.75203109
52SUZ12_27294783_Chip-Seq_ESCs_Mouse1.74775612
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.74655502
54ZNF274_21170338_ChIP-Seq_K562_Hela1.73800417
55FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.73780011
56REST_21632747_ChIP-Seq_MESCs_Mouse1.73624911
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.73237430
58AR_21909140_ChIP-Seq_LNCAP_Human1.72242955
59CDX2_19796622_ChIP-Seq_MESCs_Mouse1.72044624
60SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.71168984
61CBX2_27304074_Chip-Seq_ESCs_Mouse1.70855107
62YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69621651
63BMI1_23680149_ChIP-Seq_NPCS_Mouse1.69119211
64ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.68406217
65MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.64737694
66CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.63026239
67PCGF2_27294783_Chip-Seq_ESCs_Mouse1.62627996
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61387776
69NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.60955994
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.59214216
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.58087291
72E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.57544005
73EWS_26573619_Chip-Seq_HEK293_Human1.53835637
74CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.53695049
75AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.53238019
76DROSHA_22980978_ChIP-Seq_HELA_Human1.52383171
77HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.52337510
78NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.51443352
79* DCP1A_22483619_ChIP-Seq_HELA_Human1.48834987
80RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.48676993
81ER_23166858_ChIP-Seq_MCF-7_Human1.47351914
82RNF2_27304074_Chip-Seq_NSC_Mouse1.47064879
83* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.45851756
84SMAD_19615063_ChIP-ChIP_OVARY_Human1.45524045
85ETS1_20019798_ChIP-Seq_JURKAT_Human1.44625736
86WT1_19549856_ChIP-ChIP_CCG9911_Human1.39375542
87PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.39252331
88STAT3_23295773_ChIP-Seq_U87_Human1.38211796
89MYC_18940864_ChIP-ChIP_HL60_Human1.35757796
90ZNF217_24962896_ChIP-Seq_MCF-7_Human1.35287315
91TP53_18474530_ChIP-ChIP_U2OS_Human1.33451495
92REST_18959480_ChIP-ChIP_MESCs_Mouse1.32187561
93FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.31409075
94* RARB_27405468_Chip-Seq_BRAIN_Mouse1.31320144
95AR_25329375_ChIP-Seq_VCAP_Human1.30638997
96SOX2_21211035_ChIP-Seq_LN229_Gbm1.29809402
97* FOXP3_21729870_ChIP-Seq_TREG_Human1.29103850
98MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.28102811
99NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27675871
100* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26539090
101TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.25974547
102TP53_16413492_ChIP-PET_HCT116_Human1.25478144
103TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23418113
104SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23038451
105JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.22289247
106VDR_22108803_ChIP-Seq_LS180_Human1.21771786
107EZH2_27294783_Chip-Seq_NPCs_Mouse1.21456645
108YAP1_20516196_ChIP-Seq_MESCs_Mouse1.20461792
109ARNT_22903824_ChIP-Seq_MCF-7_Human1.19940510
110TCF4_23295773_ChIP-Seq_U87_Human1.18853833
111TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18555648
112E2F1_21310950_ChIP-Seq_MCF-7_Human1.16435957
113POU5F1_16153702_ChIP-ChIP_HESCs_Human1.15939250
114MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15605898
115JUN_21703547_ChIP-Seq_K562_Human1.15473442
116THAP11_20581084_ChIP-Seq_MESCs_Mouse1.15015983
117HOXB4_20404135_ChIP-ChIP_EML_Mouse1.14994959
118RUNX2_22187159_ChIP-Seq_PCA_Human1.14917468
119TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14841407
120NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13646491
121* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.13561121
122IGF1R_20145208_ChIP-Seq_DFB_Human1.12354858
123CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12309085
124NANOG_18555785_Chip-Seq_ESCs_Mouse1.11079295
125PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11074853
126NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.10459510
127NRF2_20460467_ChIP-Seq_MEFs_Mouse1.10459510
128SRF_21415370_ChIP-Seq_HL-1_Mouse1.09566651
129MYC_18555785_ChIP-Seq_MESCs_Mouse1.08937058
130SOX9_26525672_Chip-Seq_HEART_Mouse1.08840143
131NOTCH1_21737748_ChIP-Seq_TLL_Human1.08553135
132* CMYC_18555785_Chip-Seq_ESCs_Mouse1.08444187
133VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.08100213
134NELFA_20434984_ChIP-Seq_ESCs_Mouse1.07807784
135CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.07533723
136E2F1_18555785_Chip-Seq_ESCs_Mouse1.06659700
137SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.06065312
138P53_22387025_ChIP-Seq_ESCs_Mouse1.06062159
139P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05826503
140TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05159211
141MYC_19030024_ChIP-ChIP_MESCs_Mouse1.04152002
142TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.04047897
143* PRDM14_20953172_ChIP-Seq_ESCs_Human1.04013834
144NFE2_27457419_Chip-Seq_LIVER_Mouse1.03947697
145* BRD4_25478319_ChIP-Seq_HGPS_Human1.03879413
146* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03789703
147* CBP_20019798_ChIP-Seq_JUKART_Human1.03789703
148RING1B_27294783_Chip-Seq_ESCs_Mouse1.03241906
149* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02741072
150RING1B_27294783_Chip-Seq_NPCs_Mouse1.02274084
151CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02178040
152SOX2_16153702_ChIP-ChIP_HESCs_Human1.01880611
153MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01735620
154STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01612013
155TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01507888
156POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01507888
157WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00663706
158* OCT4_18555785_Chip-Seq_ESCs_Mouse0.99198588
159CRX_20693478_ChIP-Seq_RETINA_Mouse0.96539439
160FOXM1_26456572_ChIP-Seq_MCF-7_Human0.96050140
161KLF5_20875108_ChIP-Seq_MESCs_Mouse0.95463009
162* P300_18555785_Chip-Seq_ESCs_Mouse0.94858921
163GATA1_22025678_ChIP-Seq_K562_Human0.93927061

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.29260540
2MP0008057_abnormal_DNA_replication3.58296743
3MP0004859_abnormal_synaptic_plasticity3.54740351
4MP0004270_analgesia3.09017837
5MP0004147_increased_porphyrin_level3.07005078
6MP0003656_abnormal_erythrocyte_physiolo2.88352800
7MP0003635_abnormal_synaptic_transmissio2.83024922
8MP0003786_premature_aging2.73094298
9MP0006292_abnormal_olfactory_placode2.61293493
10MP0008058_abnormal_DNA_repair2.58191766
11MP0003111_abnormal_nucleus_morphology2.50081772
12MP0010094_abnormal_chromosome_stability2.49985626
13MP0000778_abnormal_nervous_system2.45637004
14MP0004043_abnormal_pH_regulation2.41801561
15MP0004957_abnormal_blastocyst_morpholog2.37730584
16MP0003950_abnormal_plasma_membrane2.35326481
17MP0000569_abnormal_digit_pigmentation2.32722614
18MP0002063_abnormal_learning/memory/cond2.31168803
19MP0009046_muscle_twitch2.30195398
20MP0001486_abnormal_startle_reflex2.29319730
21MP0001984_abnormal_olfaction2.24640080
22* MP0009745_abnormal_behavioral_response2.24030859
23* MP0002064_seizures2.23402829
24MP0005423_abnormal_somatic_nervous2.14911860
25MP0002272_abnormal_nervous_system2.11042622
26MP0006276_abnormal_autonomic_nervous2.07729628
27MP0002734_abnormal_mechanical_nocicepti2.05997587
28MP0001968_abnormal_touch/_nociception2.05289497
29MP0001188_hyperpigmentation2.02271987
30MP0002572_abnormal_emotion/affect_behav2.02104225
31MP0000372_irregular_coat_pigmentation1.96261799
32MP0002184_abnormal_innervation1.87768835
33MP0002090_abnormal_vision1.85841631
34MP0004742_abnormal_vestibular_system1.81011631
35* MP0002067_abnormal_sensory_capabilities1.80381542
36MP0001529_abnormal_vocalization1.79588739
37MP0001440_abnormal_grooming_behavior1.78022465
38MP0005171_absent_coat_pigmentation1.76039798
39MP0003077_abnormal_cell_cycle1.75391990
40MP0003122_maternal_imprinting1.73140303
41MP0008932_abnormal_embryonic_tissue1.72568826
42MP0002736_abnormal_nociception_after1.66455077
43MP0008877_abnormal_DNA_methylation1.66143930
44MP0003136_yellow_coat_color1.65534818
45MP0001501_abnormal_sleep_pattern1.60750003
46MP0004885_abnormal_endolymph1.58436223
47MP0002735_abnormal_chemical_nociception1.53825730
48MP0002882_abnormal_neuron_morphology1.50789614
49MP0002557_abnormal_social/conspecific_i1.46666158
50MP0005551_abnormal_eye_electrophysiolog1.45049954
51MP0000631_abnormal_neuroendocrine_gland1.45036079
52MP0002733_abnormal_thermal_nociception1.44295071
53MP0003890_abnormal_embryonic-extraembry1.43109186
54MP0004142_abnormal_muscle_tone1.41436040
55MP0000955_abnormal_spinal_cord1.41419820
56MP0005187_abnormal_penis_morphology1.39208229
57MP0005386_behavior/neurological_phenoty1.38037365
58MP0004924_abnormal_behavior1.38037365
59MP0003121_genomic_imprinting1.36162966
60MP0000920_abnormal_myelination1.35569213
61MP0005503_abnormal_tendon_morphology1.35502049
62MP0001970_abnormal_pain_threshold1.34788014
63MP0008569_lethality_at_weaning1.33048628
64MP0005623_abnormal_meninges_morphology1.30834051
65MP0003693_abnormal_embryo_hatching1.30132886
66MP0001485_abnormal_pinna_reflex1.26351740
67MP0005409_darkened_coat_color1.25406009
68MP0000647_abnormal_sebaceous_gland1.25020542
69MP0006072_abnormal_retinal_apoptosis1.22823141
70MP0004858_abnormal_nervous_system1.22783059
71MP0003123_paternal_imprinting1.20518443
72MP0001905_abnormal_dopamine_level1.20475379
73MP0005408_hypopigmentation1.20092908
74MP0003787_abnormal_imprinting1.20076061
75MP0010352_gastrointestinal_tract_polyps1.20056649
76MP0003941_abnormal_skin_development1.19522378
77* MP0003634_abnormal_glial_cell1.18655856
78MP0004811_abnormal_neuron_physiology1.17947321
79MP0002752_abnormal_somatic_nervous1.16623236
80MP0002152_abnormal_brain_morphology1.16548490
81MP0006054_spinal_hemorrhage1.16100509
82* MP0009697_abnormal_copulation1.15075505
83MP0001697_abnormal_embryo_size1.13683859
84* MP0002066_abnormal_motor_capabilities/c1.13433876
85MP0001299_abnormal_eye_distance/1.13303974
86MP0009250_abnormal_appendicular_skeleto1.12708732
87MP0008007_abnormal_cellular_replicative1.12603951
88MP0001177_atelectasis1.10273740
89MP0004145_abnormal_muscle_electrophysio1.10099246
90MP0000749_muscle_degeneration1.09228090
91MP0002108_abnormal_muscle_morphology1.08961589
92MP0004510_myositis1.07672939
93MP0002084_abnormal_developmental_patter1.06043869
94MP0003718_maternal_effect1.04324354
95MP0009703_decreased_birth_body1.03616696
96MP0010030_abnormal_orbit_morphology1.03446098
97MP0000566_synostosis1.03093293
98MP0005394_taste/olfaction_phenotype1.01054464
99MP0005499_abnormal_olfactory_system1.01054464
100MP0004197_abnormal_fetal_growth/weight/1.00877109
101MP0004215_abnormal_myocardial_fiber0.99048685
102MP0005646_abnormal_pituitary_gland0.98878579
103MP0005645_abnormal_hypothalamus_physiol0.97631222
104MP0002095_abnormal_skin_pigmentation0.97450904
105MP0006035_abnormal_mitochondrial_morpho0.97081259
106MP0003221_abnormal_cardiomyocyte_apopto0.96608199
107MP0002938_white_spotting0.96494771
108MP0001963_abnormal_hearing_physiology0.96246829
109MP0009780_abnormal_chondrocyte_physiolo0.96073603
110MP0001672_abnormal_embryogenesis/_devel0.95670529
111MP0005380_embryogenesis_phenotype0.95670529
112MP0003861_abnormal_nervous_system0.95512336
113MP0002751_abnormal_autonomic_nervous0.94973059
114MP0001286_abnormal_eye_development0.94550599
115MP0002085_abnormal_embryonic_tissue0.93764644
116MP0000427_abnormal_hair_cycle0.92998779
117MP0001502_abnormal_circadian_rhythm0.92822100
118MP0000537_abnormal_urethra_morphology0.90531340
119MP0000350_abnormal_cell_proliferation0.90426982
120MP0001929_abnormal_gametogenesis0.89683576
121MP0000026_abnormal_inner_ear0.89285523
122MP0002229_neurodegeneration0.88773854
123MP0003984_embryonic_growth_retardation0.87583501
124MP0002088_abnormal_embryonic_growth/wei0.86424439
125MP0002102_abnormal_ear_morphology0.85937926
126MP0000015_abnormal_ear_pigmentation0.85798987
127MP0005391_vision/eye_phenotype0.85100186
128MP0003329_amyloid_beta_deposits0.84927022
129MP0002177_abnormal_outer_ear0.84655024
130MP0004134_abnormal_chest_morphology0.84462119
131MP0005195_abnormal_posterior_eye0.84097323
132MP0003755_abnormal_palate_morphology0.83987085
133MP0005075_abnormal_melanosome_morpholog0.83790044
134MP0003385_abnormal_body_wall0.82696977
135MP0005253_abnormal_eye_physiology0.81970122
136* MP0002080_prenatal_lethality0.81891417
137MP0008789_abnormal_olfactory_epithelium0.81883351
138MP0005248_abnormal_Harderian_gland0.81677654
139MP0001730_embryonic_growth_arrest0.79731273
140MP0003938_abnormal_ear_development0.79616345
141MP0000358_abnormal_cell_content/0.79546963
142MP0003937_abnormal_limbs/digits/tail_de0.79480462
143MP0003632_abnormal_nervous_system0.79161150
144MP0002234_abnormal_pharynx_morphology0.78123170
145* MP0003698_abnormal_male_reproductive0.78086204
146MP0002233_abnormal_nose_morphology0.77710797
147MP0001186_pigmentation_phenotype0.77047520
148MP0002075_abnormal_coat/hair_pigmentati0.76689503
149MP0005174_abnormal_tail_pigmentation0.76641349
150MP0000653_abnormal_sex_gland0.74819985
151MP0003115_abnormal_respiratory_system0.74800796
152MP0002210_abnormal_sex_determination0.74658297
153MP0008995_early_reproductive_senescence0.74609538
154MP0009379_abnormal_foot_pigmentation0.73639645
155MP0002160_abnormal_reproductive_system0.71737043
156MP0001943_abnormal_respiration0.71571320
157MP0001293_anophthalmia0.71318537
158MP0002086_abnormal_extraembryonic_tissu0.70907294
159MP0001958_emphysema0.70785893
160MP0004133_heterotaxia0.70233752
161MP0002081_perinatal_lethality0.69672927

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)3.98611200
2Myokymia (HP:0002411)3.56213244
3Focal seizures (HP:0007359)3.34943796
4Broad-based gait (HP:0002136)3.33729225
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.28634371
6Upper limb muscle weakness (HP:0003484)3.21576412
7Abnormality of the hip-girdle musculature (HP:0001445)3.20224370
8Abnormality of the musculature of the pelvis (HP:0001469)3.20224370
9Absent speech (HP:0001344)2.99189728
10Epileptic encephalopathy (HP:0200134)2.98483695
11Cortical dysplasia (HP:0002539)2.96851094
12Submucous cleft hard palate (HP:0000176)2.91271292
13Hypothermia (HP:0002045)2.91090911
14Chromsome breakage (HP:0040012)2.89705147
15Thyroid carcinoma (HP:0002890)2.82919938
16Meckel diverticulum (HP:0002245)2.81114402
17Aplasia/Hypoplasia of the uvula (HP:0010293)2.78381946
18Abnormality of the heme biosynthetic pathway (HP:0010472)2.77233860
19Poikilocytosis (HP:0004447)2.76956352
20Excessive salivation (HP:0003781)2.76750036
21Drooling (HP:0002307)2.76750036
22Retinal dysplasia (HP:0007973)2.76260904
23Papillary thyroid carcinoma (HP:0002895)2.75256722
24Nephronophthisis (HP:0000090)2.73977969
25Termporal pattern (HP:0011008)2.70199631
26Insidious onset (HP:0003587)2.70199631
27Abnormality of chromosome stability (HP:0003220)2.69149938
28Abnormality of the ileum (HP:0001549)2.67780620
29Hyperventilation (HP:0002883)2.67549396
30Progressive cerebellar ataxia (HP:0002073)2.66699962
31Volvulus (HP:0002580)2.60305818
32Degeneration of the lateral corticospinal tracts (HP:0002314)2.59381795
33Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.59381795
34Febrile seizures (HP:0002373)2.59123404
35Gait imbalance (HP:0002141)2.56687650
36Atonic seizures (HP:0010819)2.56376971
37Hyperinsulinemic hypoglycemia (HP:0000825)2.52995660
38Ankle clonus (HP:0011448)2.48565182
39Blue irides (HP:0000635)2.46869016
40Intestinal atresia (HP:0011100)2.46275048
41Abnormality of the corticospinal tract (HP:0002492)2.43952719
42Clumsiness (HP:0002312)2.36273718
43Aqueductal stenosis (HP:0002410)2.34491651
44Protruding tongue (HP:0010808)2.34035742
45Fetal akinesia sequence (HP:0001989)2.33506890
46Scanning speech (HP:0002168)2.32264715
47Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.30308204
48Sensory axonal neuropathy (HP:0003390)2.28600300
49Genital tract atresia (HP:0001827)2.28176358
50Vaginal atresia (HP:0000148)2.27637820
51Autoamputation (HP:0001218)2.27402151
52Aplasia/Hypoplasia of the brainstem (HP:0007362)2.26461573
53Hypoplasia of the brainstem (HP:0002365)2.26461573
54Tongue fasciculations (HP:0001308)2.25446772
55Small intestinal stenosis (HP:0012848)2.25423457
56Duodenal stenosis (HP:0100867)2.25423457
57Abnormality of the renal medulla (HP:0100957)2.24761696
58Abnormality of the preputium (HP:0100587)2.23632560
59Limb dystonia (HP:0002451)2.20096131
60Congenital primary aphakia (HP:0007707)2.19881501
61Abnormality of the fovea (HP:0000493)2.18916412
62Aplasia involving bones of the extremities (HP:0009825)2.18471344
63Aplasia involving bones of the upper limbs (HP:0009823)2.18471344
64Aplasia of the phalanges of the hand (HP:0009802)2.18471344
65Postaxial foot polydactyly (HP:0001830)2.17731220
66Limb-girdle muscle atrophy (HP:0003797)2.17551343
67Megalencephaly (HP:0001355)2.17537428
68Abnormal auditory evoked potentials (HP:0006958)2.17140977
69Abnormality of the labia minora (HP:0012880)2.15993363
70Medial flaring of the eyebrow (HP:0010747)2.14197051
71Abnormal hair whorl (HP:0010721)2.13890734
72Abnormality of salivation (HP:0100755)2.13629408
73Hypoplasia of the capital femoral epiphysis (HP:0003090)2.12642561
74Abnormality of the calf musculature (HP:0001430)2.12004590
75Gaze-evoked nystagmus (HP:0000640)2.11625603
76Neurofibrillary tangles (HP:0002185)2.11119606
77Akinesia (HP:0002304)2.10412797
78Abnormality of the duodenum (HP:0002246)2.09974859
79Myelodysplasia (HP:0002863)2.09693487
80Specific learning disability (HP:0001328)2.09691324
81Buphthalmos (HP:0000557)2.07829562
82Dialeptic seizures (HP:0011146)2.07076795
83Limb-girdle muscle weakness (HP:0003325)2.06410299
84Widely spaced teeth (HP:0000687)2.06031532
85Curly hair (HP:0002212)2.05883639
86Postnatal microcephaly (HP:0005484)2.04150838
87Abnormality of incisor morphology (HP:0011063)2.04093141
88Pheochromocytoma (HP:0002666)2.03768348
89Thickened helices (HP:0000391)2.03144205
90Lissencephaly (HP:0001339)2.00885975
91Alacrima (HP:0000522)2.00711444
92Sloping forehead (HP:0000340)1.99898697
93Scapular winging (HP:0003691)1.99626187
94Aplasia/Hypoplasia of the fovea (HP:0008060)1.99304333
95Hypoplasia of the fovea (HP:0007750)1.99304333
96Nephrogenic diabetes insipidus (HP:0009806)1.98960707
97Absence seizures (HP:0002121)1.98809858
98Anophthalmia (HP:0000528)1.97453782
99Visual hallucinations (HP:0002367)1.96802315
100Spastic gait (HP:0002064)1.96618451
101Progressive inability to walk (HP:0002505)1.96528491
102Exotropia (HP:0000577)1.95941347
103Myelomeningocele (HP:0002475)1.95206425
104Rimmed vacuoles (HP:0003805)1.94213491
105Narrow nasal bridge (HP:0000446)1.94203083
106Abnormal lung lobation (HP:0002101)1.94167364
107Abnormality of the metopic suture (HP:0005556)1.92666187
108Peripheral hypomyelination (HP:0007182)1.92438497
109Fair hair (HP:0002286)1.92016601
110Abnormal eating behavior (HP:0100738)1.91808677
111Cystic hygroma (HP:0000476)1.90888862
112Type II lissencephaly (HP:0007260)1.89225895
113Cutaneous melanoma (HP:0012056)1.89144683
114Truncal ataxia (HP:0002078)1.88550317
115Embryonal renal neoplasm (HP:0011794)1.88242564
116Albinism (HP:0001022)1.86600045
117Breast carcinoma (HP:0003002)1.86316314
118Postaxial hand polydactyly (HP:0001162)1.86109502
119Nephroblastoma (Wilms tumor) (HP:0002667)1.85792620
120Prominent metopic ridge (HP:0005487)1.85513709
121Esotropia (HP:0000565)1.85316655
122Neuroendocrine neoplasm (HP:0100634)1.84790409
123Polyphagia (HP:0002591)1.84447785
124Neoplasm of the adrenal cortex (HP:0100641)1.84129841
125Midline defect of the nose (HP:0004122)1.83882864
126Lower limb muscle weakness (HP:0007340)1.82073808
127Inappropriate behavior (HP:0000719)1.81524973
128Action tremor (HP:0002345)1.80083580
129Mutism (HP:0002300)1.78345547
130Biliary tract neoplasm (HP:0100574)1.77729863
131Astigmatism (HP:0000483)1.77641692
132Shoulder girdle muscle weakness (HP:0003547)1.77184285
133Generalized tonic-clonic seizures (HP:0002069)1.76398775
134Supranuclear gaze palsy (HP:0000605)1.75823570
135Neoplasm of the adrenal gland (HP:0100631)1.74472129
136Long clavicles (HP:0000890)1.72619556
137Absent septum pellucidum (HP:0001331)1.72280955
138Decreased lacrimation (HP:0000633)1.71540949
139Pancreatic islet-cell hyperplasia (HP:0004510)1.71412025
140Aplasia/Hypoplasia of the lens (HP:0008063)1.71137031
141Muscle fibrillation (HP:0010546)1.70505964
142Cupped ear (HP:0000378)1.70082224
143Meningocele (HP:0002435)1.69076071
144Thyroiditis (HP:0100646)1.68588634
145Intellectual disability, moderate (HP:0002342)1.68362497
146Dysdiadochokinesis (HP:0002075)1.68132707
147Abnormality of the parathyroid morphology (HP:0011766)1.68026694
148Abnormality of methionine metabolism (HP:0010901)1.63477618
149Chin dimple (HP:0010751)1.63249034
150Abnormality of the septum pellucidum (HP:0007375)1.63109531
151Abnormality of the shoulder girdle musculature (HP:0001435)1.62280986
152Clubbing of toes (HP:0100760)1.62141526
153Poor coordination (HP:0002370)1.61814380
154Narrow forehead (HP:0000341)1.61550721
155Tracheomalacia (HP:0002779)1.61506469
156Cerebral inclusion bodies (HP:0100314)1.61381474
157Generalized hypopigmentation of hair (HP:0011358)1.61078730
158Neoplasm of the colon (HP:0100273)1.60923353
159Pancreatic fibrosis (HP:0100732)1.60673237
160Humeroradial synostosis (HP:0003041)1.60582650
161Synostosis involving the elbow (HP:0003938)1.60582650
162Transitional cell carcinoma of the bladder (HP:0006740)1.60265443
163Urinary bladder sphincter dysfunction (HP:0002839)1.60177696
164Dysmetria (HP:0001310)1.60115267
165Chronic hepatic failure (HP:0100626)1.60054505
166Prominent nose (HP:0000448)1.59580738
167Pancreatic cysts (HP:0001737)1.58833481
168Bladder carcinoma (HP:0002862)1.57204788
169Bladder neoplasm (HP:0009725)1.57204788
170Supernumerary spleens (HP:0009799)1.56589390
171Exertional dyspnea (HP:0002875)1.56183921
172Neoplasm of the small intestine (HP:0100833)1.55393537
173Acute myeloid leukemia (HP:0004808)1.54867502
174Small hand (HP:0200055)1.52472672
175Abnormality of the renal cortex (HP:0011035)1.51165340
176Abnormality of the anterior horn cell (HP:0006802)1.51036993
177Degeneration of anterior horn cells (HP:0002398)1.51036993
178Prominent nasal bridge (HP:0000426)1.50258905
179Amyotrophic lateral sclerosis (HP:0007354)1.49871286
180Overlapping toe (HP:0001845)1.48173672

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS15.96823547
2CASK4.96371345
3NUAK13.84589192
4MARK13.23387242
5EIF2AK13.13697929
6CDC72.83120740
7TNIK2.75692468
8NTRK32.71998470
9EIF2AK32.70962139
10EPHA42.51023747
11TRIM282.50133485
12PLK42.44432164
13CAMKK22.30770854
14MAP2K72.28722186
15MAP3K42.25979030
16MINK12.25303953
17IRAK12.14067841
18MAPK132.00155503
19ERBB31.86248745
20BCR1.81988646
21OXSR11.81808740
22PLK21.80924693
23MAP4K21.77339324
24SRPK11.76206371
25UHMK11.73248393
26NEK11.70765118
27STK391.69724700
28PNCK1.59510184
29PRPF4B1.58977338
30PAK61.58721173
31ZAK1.57539376
32KSR11.56420419
33WNK31.55742870
34WEE11.55512945
35LIMK11.55097690
36PBK1.54237249
37TTK1.54119935
38DYRK31.53741734
39MAP3K121.52454489
40BRD41.49806481
41STK31.48599830
42NTRK21.40599480
43FGFR21.39340895
44SGK4941.39012372
45SGK2231.39012372
46MUSK1.33913958
47CDK191.30022377
48PINK11.29718537
49TSSK61.29605501
50CSNK1G21.21617402
51CDK51.19064908
52MAP3K91.17343037
53CSNK1G31.16117516
54CAMK2B1.14594116
55CDK81.14216312
56YES11.13849813
57ACVR1B1.13662370
58DYRK21.11282848
59FES1.11236016
60ROCK21.10589855
61RPS6KA41.07349035
62CSNK1A1L1.06355794
63CDK141.05902647
64PKN11.04945952
65CDK181.01372684
66CAMK2A0.99666535
67BMPR1B0.99444546
68NEK60.97586226
69CAMKK10.95267035
70PLK10.93572022
71VRK10.93057753
72PAK30.93030235
73CDK150.92466596
74NTRK10.91490179
75CAMK1D0.89777813
76MAP2K40.86719136
77SGK20.85756335
78FER0.84875698
79DYRK1A0.81946801
80TYRO30.80650865
81SIK30.79578776
82MAPKAPK30.78726724
83PRKCE0.77770225
84CDK11A0.76631424
85MKNK20.76278696
86PRKCG0.75021759
87IRAK20.74597362
88FRK0.73863996
89STK160.73635682
90CSNK1G10.73281349
91MKNK10.72182974
92PTK2B0.70630045
93TAF10.70595557
94PDK20.70002541
95ROCK10.69758882
96CAMK2D0.69481890
97PHKG10.67852173
98PHKG20.67852173
99RPS6KA20.66849819
100STK110.66519530
101DAPK20.66075641
102CCNB10.65359216
103MST40.64479968
104AKT30.64103862
105EIF2AK20.62539404
106CDK90.62243481
107WNK10.59709581
108GRK50.54720970
109SGK10.52979966
110CAMK2G0.52915304
111EPHB20.51139202
112VRK20.50384625
113ERBB40.50318646
114BUB10.49921868
115CAMK1G0.49719724
116ATM0.49608151
117CHEK10.48209084
118TRPM70.46741190
119FGR0.46657763
120MAPKAPK50.46457627
121PRKACB0.46087703
122CAMK10.45276106
123PRKG10.45235260
124CLK10.45000483
125MARK20.44418374
126FGFR10.44061382
127ADRBK20.43763002
128BRAF0.43436725
129AURKB0.42959440
130BRSK20.42794935
131NME10.40470257
132ADRBK10.39939178
133CHEK20.39847479
134PLK30.38649360
135MAPK100.37840210
136EPHA30.37636568
137BRSK10.35881075
138MARK30.35252431
139CDK30.34252269
140PRKD30.34080996
141TAOK20.33933710
142STK38L0.33589950
143GRK10.33178507
144ATR0.32153528
145NEK20.31786947
146NLK0.30824200
147SCYL20.28910231
148CDK10.23453432
149CSNK1E0.22813185
150STK40.21499888
151DAPK10.20661756
152MAP3K60.19632264
153EEF2K0.18646639
154OBSCN0.18359071
155MAP3K50.17840672
156CSNK1D0.17794305
157MET0.16473666

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030223.51619920
2Nicotine addiction_Homo sapiens_hsa050333.42982813
3Protein export_Homo sapiens_hsa030603.01840570
4Non-homologous end-joining_Homo sapiens_hsa034502.84552600
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.73997326
6Proteasome_Homo sapiens_hsa030502.65791797
7Synaptic vesicle cycle_Homo sapiens_hsa047212.54366837
8Glutamatergic synapse_Homo sapiens_hsa047242.49213524
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.48752317
10Fatty acid elongation_Homo sapiens_hsa000622.43552314
11GABAergic synapse_Homo sapiens_hsa047272.41379407
12Nucleotide excision repair_Homo sapiens_hsa034202.41063736
13Mismatch repair_Homo sapiens_hsa034302.40440784
14Cell cycle_Homo sapiens_hsa041102.35946225
15Circadian entrainment_Homo sapiens_hsa047132.23246244
16Olfactory transduction_Homo sapiens_hsa047402.14495844
17Morphine addiction_Homo sapiens_hsa050322.14062361
18Dopaminergic synapse_Homo sapiens_hsa047282.13634166
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.13310790
20Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.12172709
21RNA degradation_Homo sapiens_hsa030182.09818738
22Axon guidance_Homo sapiens_hsa043602.09451236
23Fanconi anemia pathway_Homo sapiens_hsa034602.08497974
24RNA transport_Homo sapiens_hsa030132.08381269
25Serotonergic synapse_Homo sapiens_hsa047262.07241263
26DNA replication_Homo sapiens_hsa030302.01069324
27Long-term potentiation_Homo sapiens_hsa047201.98696212
28Long-term depression_Homo sapiens_hsa047301.92037097
29Collecting duct acid secretion_Homo sapiens_hsa049661.91716637
30Cholinergic synapse_Homo sapiens_hsa047251.83295879
31Amphetamine addiction_Homo sapiens_hsa050311.81756614
32Selenocompound metabolism_Homo sapiens_hsa004501.71891818
33Spliceosome_Homo sapiens_hsa030401.71366386
34Taste transduction_Homo sapiens_hsa047421.68519431
35mRNA surveillance pathway_Homo sapiens_hsa030151.65279313
36Cocaine addiction_Homo sapiens_hsa050301.63548753
37Salivary secretion_Homo sapiens_hsa049701.61803627
38Phototransduction_Homo sapiens_hsa047441.60861169
39Regulation of autophagy_Homo sapiens_hsa041401.57382891
40Propanoate metabolism_Homo sapiens_hsa006401.55131420
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.53569997
42RNA polymerase_Homo sapiens_hsa030201.52418672
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.46033902
44Renin secretion_Homo sapiens_hsa049241.45856822
45Gap junction_Homo sapiens_hsa045401.44879336
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.37113488
47Gastric acid secretion_Homo sapiens_hsa049711.36689916
48Homologous recombination_Homo sapiens_hsa034401.36279201
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.31359884
50Oxytocin signaling pathway_Homo sapiens_hsa049211.29077773
51ErbB signaling pathway_Homo sapiens_hsa040121.27750789
52Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.26542054
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.24999409
54Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.21856952
55Vibrio cholerae infection_Homo sapiens_hsa051101.16576095
56GnRH signaling pathway_Homo sapiens_hsa049121.13822979
57Insulin secretion_Homo sapiens_hsa049111.11086111
58Aldosterone synthesis and secretion_Homo sapiens_hsa049251.10334297
59Alcoholism_Homo sapiens_hsa050341.10166484
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.09537731
61One carbon pool by folate_Homo sapiens_hsa006701.07642754
62Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.06779949
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.04384942
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.04288941
65p53 signaling pathway_Homo sapiens_hsa041151.04247578
66Calcium signaling pathway_Homo sapiens_hsa040201.03748537
67Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.02568086
68Steroid biosynthesis_Homo sapiens_hsa001001.00796281
69Melanogenesis_Homo sapiens_hsa049161.00089488
70Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99924957
71Renal cell carcinoma_Homo sapiens_hsa052110.99562464
72Oocyte meiosis_Homo sapiens_hsa041140.98835955
73cAMP signaling pathway_Homo sapiens_hsa040240.97415553
74Lysine degradation_Homo sapiens_hsa003100.95293080
75Ether lipid metabolism_Homo sapiens_hsa005650.93270613
76Glioma_Homo sapiens_hsa052140.91542494
77Butanoate metabolism_Homo sapiens_hsa006500.91097533
78Pyrimidine metabolism_Homo sapiens_hsa002400.90795072
79Dilated cardiomyopathy_Homo sapiens_hsa054140.89127484
80Ras signaling pathway_Homo sapiens_hsa040140.89089072
81Base excision repair_Homo sapiens_hsa034100.88907002
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86760865
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.85585180
84Hedgehog signaling pathway_Homo sapiens_hsa043400.85330473
85Estrogen signaling pathway_Homo sapiens_hsa049150.85251590
86Pyruvate metabolism_Homo sapiens_hsa006200.85247066
87Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.84494702
88Colorectal cancer_Homo sapiens_hsa052100.82985614
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.81988886
90Choline metabolism in cancer_Homo sapiens_hsa052310.81565104
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.80971508
92Cardiac muscle contraction_Homo sapiens_hsa042600.79048381
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.78740881
94Wnt signaling pathway_Homo sapiens_hsa043100.77843826
95MAPK signaling pathway_Homo sapiens_hsa040100.77757119
96Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.77376883
97Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.77132359
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.75742713
99Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75301345
100Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.74901207
101Basal cell carcinoma_Homo sapiens_hsa052170.74692910
102Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.74505775
103Sulfur metabolism_Homo sapiens_hsa009200.74476677
104Tight junction_Homo sapiens_hsa045300.74356022
105Dorso-ventral axis formation_Homo sapiens_hsa043200.73667845
106Rap1 signaling pathway_Homo sapiens_hsa040150.73392981
107Melanoma_Homo sapiens_hsa052180.73213970
108Vascular smooth muscle contraction_Homo sapiens_hsa042700.71571084
109Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71048889
110Adherens junction_Homo sapiens_hsa045200.70736324
111Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.70720915
112Hippo signaling pathway_Homo sapiens_hsa043900.70623326
113SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68320161
114Purine metabolism_Homo sapiens_hsa002300.68103066
115cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67943414
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66903476
117Endometrial cancer_Homo sapiens_hsa052130.66690599
118Huntingtons disease_Homo sapiens_hsa050160.66414430
119Oxidative phosphorylation_Homo sapiens_hsa001900.66348205
120Alzheimers disease_Homo sapiens_hsa050100.65110599
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62779927
122Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62020877
123Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.61843152
124Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59849789
125Viral myocarditis_Homo sapiens_hsa054160.57501237
126Sphingolipid metabolism_Homo sapiens_hsa006000.57079889
127Nitrogen metabolism_Homo sapiens_hsa009100.56521158
128Vitamin B6 metabolism_Homo sapiens_hsa007500.55597176
129Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54993900
130Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54973570
131Circadian rhythm_Homo sapiens_hsa047100.52942144
132Viral carcinogenesis_Homo sapiens_hsa052030.52296132
133Neurotrophin signaling pathway_Homo sapiens_hsa047220.51154896
134FoxO signaling pathway_Homo sapiens_hsa040680.50335752
135Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50299045
136Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48812487
137Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48336287
138Type II diabetes mellitus_Homo sapiens_hsa049300.48019428
139PI3K-Akt signaling pathway_Homo sapiens_hsa041510.47506252
140ECM-receptor interaction_Homo sapiens_hsa045120.47139008
141Parkinsons disease_Homo sapiens_hsa050120.46926399
142Phagosome_Homo sapiens_hsa041450.46471814
143Pancreatic secretion_Homo sapiens_hsa049720.46172359
144* Endocytosis_Homo sapiens_hsa041440.44465182
145Thyroid hormone synthesis_Homo sapiens_hsa049180.43794196
146Focal adhesion_Homo sapiens_hsa045100.43326804
147MicroRNAs in cancer_Homo sapiens_hsa052060.41862445
148TGF-beta signaling pathway_Homo sapiens_hsa043500.41454982
149Thyroid cancer_Homo sapiens_hsa052160.39191817
150Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37318738
151Prostate cancer_Homo sapiens_hsa052150.34636455
152Metabolic pathways_Homo sapiens_hsa011000.33893024
153Glutathione metabolism_Homo sapiens_hsa004800.30882124
154Glucagon signaling pathway_Homo sapiens_hsa049220.30155977
155N-Glycan biosynthesis_Homo sapiens_hsa005100.28930962
156Peroxisome_Homo sapiens_hsa041460.25308362
157Fatty acid metabolism_Homo sapiens_hsa012120.24262917

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