STAG3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is expressed in the nucleus and is a subunit of the cohesin complex which regulates the cohesion of sister chromatids during cell division. A mutation in this gene is associated with premature ovarian failure. Alternate splicing results in multiple transcript variants encoding distinct isoforms. This gene has multiple pseudogenes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)9.62604796
2male meiosis (GO:0007140)9.47828821
3sperm motility (GO:0030317)8.83524941
4DNA methylation involved in gamete generation (GO:0043046)8.59783869
5axonemal dynein complex assembly (GO:0070286)8.23677891
6sperm-egg recognition (GO:0035036)8.19008537
7* synaptonemal complex organization (GO:0070193)8.00944508
8binding of sperm to zona pellucida (GO:0007339)7.81384022
9* synaptonemal complex assembly (GO:0007130)7.77696270
10acrosome assembly (GO:0001675)7.74124116
11spermatid development (GO:0007286)7.48349498
12multicellular organism reproduction (GO:0032504)7.46698776
13epithelial cilium movement (GO:0003351)7.30697656
14cell-cell recognition (GO:0009988)7.29199250
15acrosome reaction (GO:0007340)7.27312258
16motile cilium assembly (GO:0044458)7.23308546
17plasma membrane fusion (GO:0045026)7.19896881
18male meiosis I (GO:0007141)6.71756584
19epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.53823316
20regulation of meiosis I (GO:0060631)6.47212687
21cilium movement (GO:0003341)6.30295217
22meiotic nuclear division (GO:0007126)6.28302108
23cell wall macromolecule metabolic process (GO:0044036)6.14558195
24cell wall macromolecule catabolic process (GO:0016998)6.14558195
25* chromosome organization involved in meiosis (GO:0070192)6.06094763
26regulation of cilium movement (GO:0003352)5.99412003
27reproduction (GO:0000003)5.97489970
28meiosis I (GO:0007127)5.55254022
29histone H3-K9 demethylation (GO:0033169)5.43136386
30microtubule depolymerization (GO:0007019)5.36694188
31regulation of female gonad development (GO:2000194)5.25669963
32gene silencing by RNA (GO:0031047)5.22704358
33nuclear pore complex assembly (GO:0051292)5.17905592
34single fertilization (GO:0007338)5.16569142
35histone H3-K36 demethylation (GO:0070544)5.15835439
36spermatogenesis (GO:0007283)5.15652287
37male gamete generation (GO:0048232)5.14654887
38germ cell development (GO:0007281)5.11047853
39fertilization (GO:0009566)5.04375118
40regulation of DNA methylation (GO:0044030)5.02790269
41meiotic cell cycle (GO:0051321)4.94798116
42interkinetic nuclear migration (GO:0022027)4.92169169
43nuclear pore organization (GO:0006999)4.76607465
44gamete generation (GO:0007276)4.75944013
45cellular process involved in reproduction in multicellular organism (GO:0022412)4.72792543
46histone lysine demethylation (GO:0070076)4.65827406
47negative regulation of inclusion body assembly (GO:0090084)4.55004931
48negative regulation of histone methylation (GO:0031061)4.54691048
49sperm capacitation (GO:0048240)4.51523545
50histone demethylation (GO:0016577)4.46721125
51seminiferous tubule development (GO:0072520)4.35969527
52synapsis (GO:0007129)4.35494116
53histone H3-K4 trimethylation (GO:0080182)4.32385161
54* meiotic cell cycle process (GO:1903046)4.23834341
55DNA alkylation (GO:0006305)4.18893066
56DNA methylation (GO:0006306)4.18893066
57ventricular system development (GO:0021591)4.15071422
58pore complex assembly (GO:0046931)4.06971509
59positive regulation of gene expression, epigenetic (GO:0045815)4.00192258
60protein demethylation (GO:0006482)3.97388153
61protein dealkylation (GO:0008214)3.97388153
62regulation of acrosome reaction (GO:0060046)3.91753818
63female gamete generation (GO:0007292)3.89991858
64regulation of histone H3-K9 methylation (GO:0051570)3.89595448
65mitotic sister chromatid cohesion (GO:0007064)3.89036259
66monoubiquitinated protein deubiquitination (GO:0035520)3.87874569
67gene silencing (GO:0016458)3.85740930
68regulation of inclusion body assembly (GO:0090083)3.84227552
69regulation of centriole replication (GO:0046599)3.81346616
70DNA packaging (GO:0006323)3.72921267
71histone H3-K4 methylation (GO:0051568)3.71747149
72regulation of microtubule-based movement (GO:0060632)3.71254869
73sister chromatid cohesion (GO:0007062)3.71185153
74multicellular organismal reproductive process (GO:0048609)3.70773072
75genitalia morphogenesis (GO:0035112)3.69627199
76DNA replication-dependent nucleosome assembly (GO:0006335)3.63845794
77DNA replication-dependent nucleosome organization (GO:0034723)3.63845794
78chaperone-mediated protein complex assembly (GO:0051131)3.62899671
79histone H3-K9 modification (GO:0061647)3.59695828
80chromosome condensation (GO:0030261)3.58826665
81protein localization to cilium (GO:0061512)3.57586785
82peptidyl-lysine trimethylation (GO:0018023)3.57029135
83regulation of protein polyubiquitination (GO:1902914)3.53616951
84histone lysine methylation (GO:0034968)3.47397348
85nucleus localization (GO:0051647)3.46957693
86regulation of histone methylation (GO:0031060)3.46627452
87negative regulation of DNA repair (GO:0045738)3.43696598
88regulation of NFAT protein import into nucleus (GO:0051532)3.43408799
89regulation of RNA export from nucleus (GO:0046831)3.37125332
90microtubule severing (GO:0051013)3.35633895
91peptidyl-lysine methylation (GO:0018022)3.34330782
92DNA methylation or demethylation (GO:0044728)3.34106703
93organic cation transport (GO:0015695)3.33020353
94cell recognition (GO:0008037)3.32926424
95regulation of spindle checkpoint (GO:0090231)3.32766952
96heterochromatin organization (GO:0070828)3.32251389
97reciprocal DNA recombination (GO:0035825)3.30435781
98reciprocal meiotic recombination (GO:0007131)3.30435781
99sex differentiation (GO:0007548)3.25653530
100intraciliary transport (GO:0042073)3.25578449
101translesion synthesis (GO:0019985)3.23730822
102positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.20943099
103positive regulation of humoral immune response (GO:0002922)3.20905131
104histone exchange (GO:0043486)3.20147267
105meiotic chromosome segregation (GO:0045132)3.18355487
106left/right pattern formation (GO:0060972)3.18165536
107nucleus organization (GO:0006997)3.17928635
108negative regulation of organelle assembly (GO:1902116)3.17894983
109mitotic chromosome condensation (GO:0007076)3.16631983
110DNA synthesis involved in DNA repair (GO:0000731)3.15437564
111oogenesis (GO:0048477)3.12029300
112negative regulation of cAMP-mediated signaling (GO:0043951)3.05752601
113L-amino acid import (GO:0043092)3.01246472
114histone H4-K16 acetylation (GO:0043984)2.99665442
115regulation of chromatin binding (GO:0035561)2.94550656
116protein K6-linked ubiquitination (GO:0085020)2.94425817
117protein polyglutamylation (GO:0018095)2.93576533
118multicellular organismal development (GO:0007275)2.91718017
119protein localization to chromosome, centromeric region (GO:0071459)2.91496843
120oocyte development (GO:0048599)2.91234862
121rRNA catabolic process (GO:0016075)2.89434812
122regulation of histone H3-K4 methylation (GO:0051569)2.89395487
123stress granule assembly (GO:0034063)2.86926954
124protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.86091938
125calcium ion-dependent exocytosis (GO:0017156)2.85116853
126histone H3-K9 methylation (GO:0051567)2.82624395
127negative regulation of meiosis (GO:0045835)2.81160290
128centriole replication (GO:0007099)2.81064341
129regulation of chromatin silencing (GO:0031935)2.80960145
130microtubule polymerization or depolymerization (GO:0031109)2.79193427
131positive regulation of histone methylation (GO:0031062)2.78881450
132histone H2A acetylation (GO:0043968)2.78053016
133establishment of nucleus localization (GO:0040023)2.77678398
134negative regulation of histone modification (GO:0031057)2.76259759
135* chromosome organization (GO:0051276)2.74772389
136protein kinase C signaling (GO:0070528)2.74740701
137retinal cone cell development (GO:0046549)2.74653442
138phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.74440790
139regulation of nucleobase-containing compound transport (GO:0032239)2.74416462
140regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.73798695
141peptidyl-lysine dimethylation (GO:0018027)2.72453397
142histone methylation (GO:0016571)2.71841514
143regulation of gene expression, epigenetic (GO:0040029)2.68059439
144phosphorelay signal transduction system (GO:0000160)2.66996590
145regulation of DNA endoreduplication (GO:0032875)2.65811136
146cerebral cortex neuron differentiation (GO:0021895)2.65751241
147glucocorticoid receptor signaling pathway (GO:0042921)2.64545300
148glycine transport (GO:0015816)2.64488277
149negative regulation of gene silencing (GO:0060969)2.64235175
150corticosteroid receptor signaling pathway (GO:0031958)2.58088275
151regulation of female receptivity (GO:0045924)2.57943202
152regulation of cell maturation (GO:1903429)2.57828049
153negative regulation of chromatin modification (GO:1903309)2.57251978
154ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.56921364
155positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.55871061
156positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.55871061
157positive regulation of mitotic sister chromatid separation (GO:1901970)2.55871061
158establishment of spindle orientation (GO:0051294)2.53724049
159positive regulation of histone H3-K4 methylation (GO:0051571)2.52909233
160DNA modification (GO:0006304)2.52778347
161embryonic body morphogenesis (GO:0010172)2.52615474
162B cell receptor signaling pathway (GO:0050853)2.52479413
163establishment of protein localization to Golgi (GO:0072600)2.49780390
164establishment of mitotic spindle orientation (GO:0000132)2.47333254
165histone H4 deacetylation (GO:0070933)2.46205068
166regulation of translation, ncRNA-mediated (GO:0045974)2.45463824
167piRNA metabolic process (GO:0034587)12.2744218
168cilium or flagellum-dependent cell motility (GO:0001539)11.0882282

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.50700121
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.70419211
3EZH2_22144423_ChIP-Seq_EOC_Human3.28741009
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.28659251
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.17494719
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.13085680
7DROSHA_22980978_ChIP-Seq_HELA_Human2.72615745
8* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.65328242
9VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.35832255
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.31658960
11GATA1_26923725_Chip-Seq_HPCs_Mouse2.21193659
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.16524585
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.08474439
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.07329391
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse11.6900275
16SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.97268174
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.96678873
18STAT6_21828071_ChIP-Seq_BEAS2B_Human1.93246048
19PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.92960721
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.89652282
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.82408830
22SALL1_21062744_ChIP-ChIP_HESCs_Human1.80777955
23* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.78885618
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.76684568
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72604702
26AR_21572438_ChIP-Seq_LNCaP_Human1.72201853
27REST_21632747_ChIP-Seq_MESCs_Mouse1.67402221
28STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.63474816
29RBPJ_22232070_ChIP-Seq_NCS_Mouse1.62758355
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56245403
31ELK4_26923725_Chip-Seq_MESODERM_Mouse1.54003850
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.53784792
33TP63_19390658_ChIP-ChIP_HaCaT_Human1.52422698
34MYC_22102868_ChIP-Seq_BL_Human1.51662616
35KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.45065440
36KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.45065440
37KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.45065440
38* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.44290722
39GBX2_23144817_ChIP-Seq_PC3_Human1.42033110
40E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.41300033
41MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.36838719
42TCF4_23295773_ChIP-Seq_U87_Human1.33789906
43TCF7_22412390_ChIP-Seq_EML_Mouse1.32754478
44STAT3_23295773_ChIP-Seq_U87_Human1.32268857
45ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.31659931
46RUNX_20019798_ChIP-Seq_JUKART_Human1.31384217
47WDR5_24793694_ChIP-Seq_LNCAP_Human1.31217678
48FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30113605
49SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.29347320
50KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.28890548
51KAP1_22055183_ChIP-Seq_ESCs_Mouse1.27252812
52KDM2B_26808549_Chip-Seq_SUP-B15_Human1.24542817
53VDR_21846776_ChIP-Seq_THP-1_Human1.24361342
54ZNF274_21170338_ChIP-Seq_K562_Hela1.24356389
55HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.23819027
56PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21971846
57VDR_22108803_ChIP-Seq_LS180_Human1.20535954
58RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.17475398
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.16906838
60AHR_22903824_ChIP-Seq_MCF-7_Human1.16315642
61EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15809163
62TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15502315
63RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.14712361
64IRF1_19129219_ChIP-ChIP_H3396_Human1.14601916
65KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.14483306
66AR_21909140_ChIP-Seq_LNCAP_Human1.14404643
67OCT4_19829295_ChIP-Seq_ESCs_Human1.14400841
68NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.14080085
69CTNNB1_20460455_ChIP-Seq_HCT116_Human1.11840022
70ARNT_22903824_ChIP-Seq_MCF-7_Human1.11773481
71AR_19668381_ChIP-Seq_PC3_Human1.11457209
72* SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.10907435
73GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10891852
74PRDM14_20953172_ChIP-Seq_ESCs_Human1.10414018
75KDM2B_26808549_Chip-Seq_DND41_Human1.08694391
76* STAT1_17558387_ChIP-Seq_HELA_Human1.08667456
77EZH2_27304074_Chip-Seq_ESCs_Mouse1.06219015
78SOX2_18555785_ChIP-Seq_MESCs_Mouse1.06071289
79NOTCH1_21737748_ChIP-Seq_TLL_Human1.05677667
80RUNX1_26923725_Chip-Seq_HPCs_Mouse1.05430392
81RARB_27405468_Chip-Seq_BRAIN_Mouse1.05241182
82SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04210231
83SOX2_22085726_ChIP-Seq_NPCs_Mouse1.03790663
84* ER_23166858_ChIP-Seq_MCF-7_Human1.02107976
85E2F1_21310950_ChIP-Seq_MCF-7_Human1.01754131
86SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.00816782
87SMRT_27268052_Chip-Seq_Bcells_Human1.00409202
88CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00057581
89SCL_19346495_ChIP-Seq_HPC-7_Human0.99868288
90REST_18959480_ChIP-ChIP_MESCs_Mouse0.99795671
91TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99657470
92CIITA_25753668_ChIP-Seq_RAJI_Human0.99054552
93GATA1_19941827_ChIP-Seq_MEL86_Mouse0.98773971
94* GATA3_21867929_ChIP-Seq_CD8_Mouse0.97804556
95* POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.96308081
96* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.96242049
97SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95759430
98GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.95634650
99YY1_22570637_ChIP-Seq_MALME-3M_Human0.94120350
100BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.93987227
101* RNF2_27304074_Chip-Seq_NSC_Mouse0.93500473
102KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.93357162
103FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93352239
104KDM2B_26808549_Chip-Seq_K562_Human0.93062166
105SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.92336695
106E2F1_17053090_ChIP-ChIP_MCF-7_Human0.92189412
107SMAD4_21799915_ChIP-Seq_A2780_Human0.91654588
108SMC4_20622854_ChIP-Seq_HELA_Human0.91374242
109SOX2_21211035_ChIP-Seq_LN229_Gbm0.91308811
110STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.91033205
111CTBP2_25329375_ChIP-Seq_LNCAP_Human0.89878250
112EZH2_27294783_Chip-Seq_ESCs_Mouse0.89530457
113MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.89040640
114GATA1_19941827_ChIP-Seq_MEL_Mouse0.88898741
115KDM2B_26808549_Chip-Seq_JURKAT_Human0.88722203
116SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88519872
117TP53_16413492_ChIP-PET_HCT116_Human0.87393888
118ESR1_20079471_ChIP-ChIP_T-47D_Human0.87063793
119SUZ12_27294783_Chip-Seq_ESCs_Mouse0.86759185
120TAL1_26923725_Chip-Seq_HPCs_Mouse0.86739657
121TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85952683
122POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.85952683
123RUNX2_22187159_ChIP-Seq_PCA_Human0.85268576
124PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85119543
125CBX2_27304074_Chip-Seq_ESCs_Mouse0.85050640
126STAT3_18555785_ChIP-Seq_MESCs_Mouse0.84798191
127GATA3_21867929_ChIP-Seq_TH1_Mouse0.84788285
128FOXA2_19822575_ChIP-Seq_HepG2_Human0.83620624
129JARID2_20075857_ChIP-Seq_MESCs_Mouse0.83476408
130EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.83364007
131ZFP281_27345836_Chip-Seq_ESCs_Mouse0.82840686
132AR_25329375_ChIP-Seq_VCAP_Human0.82169115
133CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82090453
134PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.81717656
135CTBP1_25329375_ChIP-Seq_LNCAP_Human0.81440014
136HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.81360619
137CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.80894988
138CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.80879782
139YY1_21170310_ChIP-Seq_MESCs_Mouse0.80602227
140GATA3_27048872_Chip-Seq_THYMUS_Human0.80457916
141TOP2B_26459242_ChIP-Seq_MCF-7_Human0.80403534
142STAT3_1855785_ChIP-Seq_MESCs_Mouse0.79143385
143CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.79116608
144MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.79098224
145KLF4_19829295_ChIP-Seq_ESCs_Human0.78992293
146E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.78957692
147LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.78868085
148WT1_25993318_ChIP-Seq_PODOCYTE_Human0.78586919
149FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.78350701
150RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.77798062
151MYC_19030024_ChIP-ChIP_MESCs_Mouse0.77735635
152TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.76883337
153TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.75970645
154NFYB_21822215_ChIP-Seq_K562_Human0.75615879
155SOX9_26525672_Chip-Seq_HEART_Mouse0.74761491
156PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.74610351
157PHF8_20622854_ChIP-Seq_HELA_Human0.73534665
158* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.73515263
159GF1_26923725_Chip-Seq_HPCs_Mouse0.73375187
160CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.72756387
161TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.72632083
162RXRA_24833708_ChIP-Seq_LIVER_Mouse0.72393428
163OCT4_18555785_Chip-Seq_ESCs_Mouse0.72296899
164KLF4_18555785_ChIP-Seq_MESCs_Mouse0.72127826
165EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.71977986
166* MYC_19079543_ChIP-ChIP_MESCs_Mouse0.71848397
167TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.71794137
168P53_21459846_ChIP-Seq_SAOS-2_Human0.71479594
169KDM5A_27292631_Chip-Seq_BREAST_Human0.71454273
170MYC_18555785_ChIP-Seq_MESCs_Mouse0.70508512
171PKCTHETA_26484144_Chip-Seq_BREAST_Human0.70379783
172SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.70050441
173SPI1_26923725_Chip-Seq_HPCs_Mouse0.69423650
174CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.68354911
175RARA_24833708_ChIP-Seq_LIVER_Mouse0.68092017
176CBP_20019798_ChIP-Seq_JUKART_Human0.68005774
177IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.68005774

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation7.46686043
2MP0003698_abnormal_male_reproductive4.97908200
3MP0001929_abnormal_gametogenesis4.95622161
4MP0002210_abnormal_sex_determination4.16039831
5MP0008057_abnormal_DNA_replication3.89556690
6MP0001145_abnormal_male_reproductive3.45576385
7MP0010094_abnormal_chromosome_stability3.15244663
8MP0002653_abnormal_ependyma_morphology3.03879918
9MP0000653_abnormal_sex_gland2.99928065
10MP0008995_early_reproductive_senescence2.83552099
11MP0005394_taste/olfaction_phenotype2.77471317
12MP0005499_abnormal_olfactory_system2.77471317
13MP0002161_abnormal_fertility/fecundity2.75791363
14MP0008058_abnormal_DNA_repair2.67407712
15MP0003111_abnormal_nucleus_morphology2.56833152
16MP0008789_abnormal_olfactory_epithelium2.54692188
17MP0003786_premature_aging2.45239719
18MP0005423_abnormal_somatic_nervous2.36097730
19MP0003879_abnormal_hair_cell2.26891084
20MP0003183_abnormal_peptide_metabolism2.14867282
21MP0002138_abnormal_hepatobiliary_system2.10678270
22MP0002160_abnormal_reproductive_system2.07219742
23MP0005410_abnormal_fertilization10.5395836
24MP0003077_abnormal_cell_cycle1.90571729
25MP0008007_abnormal_cellular_replicative1.82990928
26MP0003693_abnormal_embryo_hatching1.78141128
27MP0005623_abnormal_meninges_morphology1.75038340
28MP0003878_abnormal_ear_physiology1.74025837
29MP0005377_hearing/vestibular/ear_phenot1.74025837
30MP0005645_abnormal_hypothalamus_physiol1.73774313
31MP0004859_abnormal_synaptic_plasticity1.70951168
32MP0004145_abnormal_muscle_electrophysio1.70066171
33MP0002822_catalepsy1.63210907
34MP0004957_abnormal_blastocyst_morpholog1.54403074
35MP0010307_abnormal_tumor_latency1.47346112
36MP0000685_abnormal_immune_system1.43703829
37MP0000778_abnormal_nervous_system1.41435510
38MP0005395_other_phenotype1.39762114
39MP0003635_abnormal_synaptic_transmissio1.38678932
40MP0002928_abnormal_bile_duct1.34887151
41MP0000631_abnormal_neuroendocrine_gland1.34656781
42MP0001730_embryonic_growth_arrest1.30727843
43MP0004270_analgesia1.29990979
44MP0005670_abnormal_white_adipose1.27962318
45MP0002735_abnormal_chemical_nociception1.26750891
46MP0002272_abnormal_nervous_system1.24634333
47MP0005389_reproductive_system_phenotype1.20641088
48MP0003880_abnormal_central_pattern1.15068955
49MP0002063_abnormal_learning/memory/cond1.13280629
50MP0000569_abnormal_digit_pigmentation1.12613784
51MP0005647_abnormal_sex_gland1.05798617
52MP0001502_abnormal_circadian_rhythm1.05508400
53MP0008932_abnormal_embryonic_tissue1.04978981
54MP0001348_abnormal_lacrimal_gland1.04639206
55MP0004381_abnormal_hair_follicle1.03211666
56MP0003763_abnormal_thymus_physiology1.03203612
57MP0001486_abnormal_startle_reflex1.02811566
58MP0006276_abnormal_autonomic_nervous1.02728193
59MP0002249_abnormal_larynx_morphology1.02543183
60MP0003646_muscle_fatigue1.02366892
61MP0004142_abnormal_muscle_tone1.01608330
62MP0003787_abnormal_imprinting1.00329280
63MP0001800_abnormal_humoral_immune0.96937195
64MP0002084_abnormal_developmental_patter0.94972987
65MP0005310_abnormal_salivary_gland0.94393798
66MP0001119_abnormal_female_reproductive0.94393060
67MP0003121_genomic_imprinting0.93542950
68MP0005380_embryogenesis_phenotype0.93300825
69MP0001672_abnormal_embryogenesis/_devel0.93300825
70MP0002067_abnormal_sensory_capabilities0.93092268
71MP0003890_abnormal_embryonic-extraembry0.93004124
72MP0000350_abnormal_cell_proliferation0.92514322
73MP0009278_abnormal_bone_marrow0.92186893
74MP0005076_abnormal_cell_differentiation0.91769674
75MP0002282_abnormal_trachea_morphology0.91261083
76MP0004233_abnormal_muscle_weight0.90862952
77MP0000955_abnormal_spinal_cord0.90071305
78MP0001986_abnormal_taste_sensitivity0.89444716
79MP0000703_abnormal_thymus_morphology0.88805217
80MP0004811_abnormal_neuron_physiology0.88258510
81MP0004808_abnormal_hematopoietic_stem0.87717279
82MP0002734_abnormal_mechanical_nocicepti0.87572944
83MP0004197_abnormal_fetal_growth/weight/0.87070478
84MP0001293_anophthalmia0.86884705
85MP0003045_fibrosis0.86807078
86MP0002085_abnormal_embryonic_tissue0.86624512
87MP0003123_paternal_imprinting0.86428865
88MP0004924_abnormal_behavior0.84963017
89MP0005386_behavior/neurological_phenoty0.84963017
90MP0005409_darkened_coat_color0.84447818
91MP0001697_abnormal_embryo_size0.83397312
92MP0008569_lethality_at_weaning0.82743904
93MP0002638_abnormal_pupillary_reflex0.82067934
94MP0000678_abnormal_parathyroid_gland0.82040889
95MP0002882_abnormal_neuron_morphology0.81868867
96MP0009745_abnormal_behavioral_response0.81632808
97MP0002398_abnormal_bone_marrow0.80009276
98MP0000313_abnormal_cell_death0.79528246
99MP0002064_seizures0.79360753
100MP0002396_abnormal_hematopoietic_system0.78545918
101MP0002572_abnormal_emotion/affect_behav0.76748239
102MP0003699_abnormal_female_reproductive0.76460934
103MP0003115_abnormal_respiratory_system0.76451329
104MP0003984_embryonic_growth_retardation0.75668945
105MP0002088_abnormal_embryonic_growth/wei0.72538778
106MP0002080_prenatal_lethality0.70713138
107MP0001963_abnormal_hearing_physiology0.70090263
108MP0000733_abnormal_muscle_development0.69832336
109MP0005646_abnormal_pituitary_gland0.69322154
110MP0004043_abnormal_pH_regulation0.67624962
111MP0003936_abnormal_reproductive_system0.67541881
112MP0002557_abnormal_social/conspecific_i0.67251576
113MP0001545_abnormal_hematopoietic_system0.67202907
114MP0005397_hematopoietic_system_phenotyp0.67202907
115MP0009115_abnormal_fat_cell0.66024098
116MP0004130_abnormal_muscle_cell0.65610353
117MP0001661_extended_life_span0.65117528
118MP0001790_abnormal_immune_system0.64099247
119MP0005387_immune_system_phenotype0.64099247
120MP0000358_abnormal_cell_content/0.63957540
121MP0004036_abnormal_muscle_relaxation0.63776633
122MP0002086_abnormal_extraembryonic_tissu0.63677610
123MP0003861_abnormal_nervous_system0.63562510
124MP0004134_abnormal_chest_morphology0.61822094
125MP0002102_abnormal_ear_morphology0.61108941
126MP0003950_abnormal_plasma_membrane0.60864240
127MP0001727_abnormal_embryo_implantation0.58376391
128MP0004133_heterotaxia0.58297474
129MP0001984_abnormal_olfaction0.55488494
130MP0003315_abnormal_perineum_morphology0.55309360
131MP0005391_vision/eye_phenotype0.54005741
132MP0000537_abnormal_urethra_morphology0.53920140
133MP0009703_decreased_birth_body0.52022105
134MP0005253_abnormal_eye_physiology0.49719521
135MP0002092_abnormal_eye_morphology0.47939010
136MP0009672_abnormal_birth_weight0.47176520
137MP0003119_abnormal_digestive_system0.46972553
138MP0002697_abnormal_eye_size0.44695916
139MP0002019_abnormal_tumor_incidence0.44680191
140MP0001915_intracranial_hemorrhage0.43277098
141MP0003718_maternal_effect0.42819762
142MP0000432_abnormal_head_morphology0.41074371
143MP0010352_gastrointestinal_tract_polyps0.39522818
144MP0006072_abnormal_retinal_apoptosis0.38041696
145MP0001919_abnormal_reproductive_system0.37478246
146MP0003937_abnormal_limbs/digits/tail_de0.36686587
147MP0000427_abnormal_hair_cycle0.36642280
148MP0003136_yellow_coat_color0.35606438
149MP0009046_muscle_twitch0.34371082
150MP0004264_abnormal_extraembryonic_tissu0.33749802
151MP0005384_cellular_phenotype0.33418108
152MP0003941_abnormal_skin_development0.33379801
153MP0006292_abnormal_olfactory_placode0.32237448
154MP0002152_abnormal_brain_morphology0.31391823
155MP0003011_delayed_dark_adaptation0.27913232
156MP0002114_abnormal_axial_skeleton0.27736951
157MP0004742_abnormal_vestibular_system0.26117873
158MP0005621_abnormal_cell_physiology0.25179000
159MP0003942_abnormal_urinary_system0.24847368
160MP0000015_abnormal_ear_pigmentation0.24735053
161MP0005551_abnormal_eye_electrophysiolog0.24426105

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)7.72216843
2Abnormal respiratory epithelium morphology (HP:0012253)7.44982182
3Abnormal respiratory motile cilium morphology (HP:0005938)7.44982182
4Rhinitis (HP:0012384)6.67522366
5Abnormal ciliary motility (HP:0012262)6.09573328
6Chronic bronchitis (HP:0004469)5.78316802
7Infertility (HP:0000789)5.50219510
8Nasal polyposis (HP:0100582)5.00408735
9Nephronophthisis (HP:0000090)4.41419932
10Abnormality of the lower motor neuron (HP:0002366)4.36722875
11Genetic anticipation (HP:0003743)4.14601318
12Abnormal spermatogenesis (HP:0008669)3.99435636
13Abnormality of the nasal mucosa (HP:0000433)3.94493891
14Bronchiectasis (HP:0002110)3.89203080
15Oligodactyly (hands) (HP:0001180)3.71463417
16Bronchitis (HP:0012387)3.59234639
17Lip pit (HP:0100267)3.59048801
18Facial hemangioma (HP:0000329)3.58329234
19Impulsivity (HP:0100710)3.57960193
20Azoospermia (HP:0000027)3.50030374
21Abnormality of the fingertips (HP:0001211)3.49270307
22Male infertility (HP:0003251)3.47335234
23Progressive cerebellar ataxia (HP:0002073)3.38075814
24Abnormality of the renal medulla (HP:0100957)3.35527683
2511 pairs of ribs (HP:0000878)3.28611826
26Amyotrophic lateral sclerosis (HP:0007354)3.05772886
27Tubulointerstitial nephritis (HP:0001970)3.02888206
28Fibular hypoplasia (HP:0003038)3.01395564
29Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.97319209
30Dysmetric saccades (HP:0000641)2.88132372
31Fair hair (HP:0002286)2.78918113
32Recurrent otitis media (HP:0000403)2.75567136
33Hyperkalemia (HP:0002153)2.74507346
34Degeneration of anterior horn cells (HP:0002398)2.73019857
35Abnormality of the anterior horn cell (HP:0006802)2.73019857
36Gaze-evoked nystagmus (HP:0000640)2.71604037
37Chromosomal breakage induced by crosslinking agents (HP:0003221)2.67753671
38Protruding tongue (HP:0010808)2.65584988
39Upper motor neuron abnormality (HP:0002127)2.62684399
40Supernumerary spleens (HP:0009799)2.59599919
41Chromsome breakage (HP:0040012)2.59212723
42Selective tooth agenesis (HP:0001592)2.57924099
43Tubular atrophy (HP:0000092)2.57349925
44Recurrent sinusitis (HP:0011108)2.52688264
45Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.47836592
46Molar tooth sign on MRI (HP:0002419)2.45313775
47Abnormality of midbrain morphology (HP:0002418)2.45313775
48Urethral obstruction (HP:0000796)2.44818618
49Abnormality of the labia minora (HP:0012880)2.43223632
50Osteomalacia (HP:0002749)2.41652941
51Ectopic kidney (HP:0000086)2.41404528
52Oligodactyly (HP:0012165)2.40145035
53Abnormality of chromosome segregation (HP:0002916)2.37913652
54Broad-based gait (HP:0002136)2.35556385
55Hypoplasia of the capital femoral epiphysis (HP:0003090)2.33702830
56Impaired smooth pursuit (HP:0007772)2.29789095
57Volvulus (HP:0002580)2.25462106
58Hyperventilation (HP:0002883)2.24965250
59Postaxial foot polydactyly (HP:0001830)2.22486994
60Papillary thyroid carcinoma (HP:0002895)2.22466036
61Obstructive sleep apnea (HP:0002870)2.20373098
62Heterotopia (HP:0002282)2.19651823
63Aplasia/Hypoplasia of the uvula (HP:0010293)2.19029883
64Tubulointerstitial abnormality (HP:0001969)2.18310140
65Anterior segment dysgenesis (HP:0007700)2.16483641
66Abnormality of chromosome stability (HP:0003220)2.15001029
67Facial cleft (HP:0002006)2.14105182
68Urinary bladder sphincter dysfunction (HP:0002839)2.13545109
69Short ribs (HP:0000773)2.13516324
70Recurrent bronchitis (HP:0002837)2.13179863
71Deep palmar crease (HP:0006191)2.11031922
72Impaired proprioception (HP:0010831)2.10860411
73Abnormality of DNA repair (HP:0003254)2.09443288
74Dysdiadochokinesis (HP:0002075)2.07060763
75Generalized hypopigmentation of hair (HP:0011358)2.06179742
76Agammaglobulinemia (HP:0004432)2.05785826
77Chronic hepatic failure (HP:0100626)2.05769524
78Meckel diverticulum (HP:0002245)2.05451212
79Missing ribs (HP:0000921)2.04875785
80Capillary hemangiomas (HP:0005306)2.04776977
81Abnormality of ocular smooth pursuit (HP:0000617)2.01870448
82Obsessive-compulsive behavior (HP:0000722)2.01704483
83Medial flaring of the eyebrow (HP:0010747)2.01599751
84Stage 5 chronic kidney disease (HP:0003774)2.00975302
85Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.4027511
86Absent/shortened dynein arms (HP:0200106)10.5160390
87Dynein arm defect of respiratory motile cilia (HP:0012255)10.5160390
88Abnormality of the ileum (HP:0001549)1.97122873
89Sloping forehead (HP:0000340)1.96569660
90Renovascular hypertension (HP:0100817)1.96328202
91Abnormality of the preputium (HP:0100587)1.95424237
92Aplasia/Hypoplasia of the fibula (HP:0006492)1.94165300
93Widely spaced teeth (HP:0000687)1.93664503
94Gastrointestinal stroma tumor (HP:0100723)1.93461090
95Exercise-induced myalgia (HP:0003738)1.93103352
96Nephroblastoma (Wilms tumor) (HP:0002667)1.92500694
97Median cleft lip (HP:0000161)1.91866080
98Hypoplastic iliac wings (HP:0002866)1.91806403
99Postural instability (HP:0002172)1.91099037
100Congenital hepatic fibrosis (HP:0002612)1.85879954
101Renal dysplasia (HP:0000110)1.85350664
102Aplasia/Hypoplasia of the sternum (HP:0006714)1.84352450
103Tented upper lip vermilion (HP:0010804)1.82483923
104Sandal gap (HP:0001852)1.81462734
105Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.81162896
106Absent epiphyses (HP:0010577)1.81162896
107Stereotypic behavior (HP:0000733)1.80406883
108Absent speech (HP:0001344)1.80096865
109Febrile seizures (HP:0002373)1.79394405
110Absent frontal sinuses (HP:0002688)1.78130585
111Increased nuchal translucency (HP:0010880)1.77620832
112Embryonal renal neoplasm (HP:0011794)1.77582192
113Spastic gait (HP:0002064)1.76274060
114Panhypogammaglobulinemia (HP:0003139)1.76008657
115Oculomotor apraxia (HP:0000657)1.73601946
116Abnormality of the carotid arteries (HP:0005344)1.73529389
117Cafe-au-lait spot (HP:0000957)1.72737317
118Abnormality of the renal cortex (HP:0011035)1.72442356
119Enlarged penis (HP:0000040)1.70763899
120Impaired vibratory sensation (HP:0002495)1.70756578
121Epileptic encephalopathy (HP:0200134)1.69692824
122Acute lymphatic leukemia (HP:0006721)1.69566207
123Highly arched eyebrow (HP:0002553)1.68583429
124Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.68408617
125Long eyelashes (HP:0000527)1.68092072
126Small intestinal stenosis (HP:0012848)1.67713240
127Duodenal stenosis (HP:0100867)1.67713240
128Short thorax (HP:0010306)1.65707737
129Skin pits (HP:0100276)1.65427392
130Supranuclear gaze palsy (HP:0000605)1.65212147
131Difficulty running (HP:0009046)1.64081069
132Breast carcinoma (HP:0003002)1.63972690
133Impaired vibration sensation in the lower limbs (HP:0002166)1.63410451
134Microglossia (HP:0000171)1.62859800
135Polycystic kidney dysplasia (HP:0000113)1.61491588
136Deeply set eye (HP:0000490)1.60550843
137Intellectual disability, severe (HP:0010864)1.60340860
138Abnormality of the columella (HP:0009929)1.59751473
139Absent thumb (HP:0009777)1.58903296
140Abnormality of the corticospinal tract (HP:0002492)1.58084754
141Atrophy/Degeneration involving motor neurons (HP:0007373)1.57884086
142Degeneration of the lateral corticospinal tracts (HP:0002314)1.57211550
143Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.57211550
144Prominent nose (HP:0000448)1.57196494
145Basal cell carcinoma (HP:0002671)1.56693267
146Fetal akinesia sequence (HP:0001989)1.56048230
147EMG: neuropathic changes (HP:0003445)1.55062761
148Intellectual disability, moderate (HP:0002342)1.54185495
149Bowel incontinence (HP:0002607)1.53749088
150Abnormality of incisor morphology (HP:0011063)1.53553324
151Thick eyebrow (HP:0000574)1.53206087
152Male pseudohermaphroditism (HP:0000037)1.53103911
153Abnormality of dentin (HP:0010299)1.53080033
154Bell-shaped thorax (HP:0001591)1.52830970
155Oligodontia (HP:0000677)1.52385058
156Postaxial hand polydactyly (HP:0001162)1.51541828
157Ependymoma (HP:0002888)1.49844990
158Clubbing of toes (HP:0100760)1.48831359
159Truncal obesity (HP:0001956)1.48309326
160Poor eye contact (HP:0000817)1.48169146
161Peripheral hypomyelination (HP:0007182)1.47523990
162Duplicated collecting system (HP:0000081)1.47465107
163Bundle branch block (HP:0011710)1.47450053
164Abnormality of permanent molar morphology (HP:0011071)1.46594836
165Abnormality of the dental root (HP:0006486)1.46594836
166Taurodontia (HP:0000679)1.46594836
167Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.43819845
168Abdominal situs inversus (HP:0003363)1.42603105
169Abnormality of abdominal situs (HP:0011620)1.42603105
170Polydipsia (HP:0001959)1.40983345
171Abnormal drinking behavior (HP:0030082)1.40983345
172Hypoplasia of the radius (HP:0002984)1.40142375
173Tubulointerstitial fibrosis (HP:0005576)1.39412751
174Abnormality of molar (HP:0011077)1.38632926
175Abnormality of molar morphology (HP:0011070)1.38632926
176High pitched voice (HP:0001620)1.35836246
177Short humerus (HP:0005792)1.35329513
178Medulloblastoma (HP:0002885)1.34400375
179Hand muscle atrophy (HP:0009130)1.33760355

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.56391441
2PDK47.56391441
3PDK25.04530533
4TESK13.90162572
5PRKD33.63488369
6MAP3K133.57661707
7ICK3.54482631
8MAP3K93.39533811
9CDK123.13133525
10SIK23.01190648
11PNCK3.00631080
12NEK22.82389884
13CDC72.73189262
14WEE12.10411019
15TTK1.84389518
16PTK2B1.81456846
17PRPF4B1.77950812
18CDK191.75559669
19MARK21.72912621
20MAP3K71.72881153
21MAP3K101.65112761
22MARK11.61420664
23WNK41.59580290
24PASK1.55956413
25INSRR1.55873075
26SGK21.50485935
27TRIB31.48942241
28STK391.45016455
29TNK21.44173657
30ATR1.41558710
31MAP4K11.39541235
32TAOK31.36593950
33OBSCN1.35991362
34FRK1.29187913
35NTRK31.23628517
36STK31.23572150
37CSF1R1.21674992
38ARAF1.19542392
39BRD41.17474499
40CHEK11.12782805
41MAPK131.12484859
42PLK11.10690119
43CHEK21.10323474
44WNK11.10079719
45SGK2231.08779260
46SGK4941.08779260
47KSR21.08541590
48CAMKK11.07945311
49CAMK1D1.06674610
50STK381.05479458
51PLK41.03651964
52SGK31.01954621
53TYRO31.01884186
54CAMK41.00777226
55BUB10.99436975
56CCNB10.98476797
57PKN10.94234692
58ACVR1B0.94122152
59SRPK10.93377738
60ATM0.92819362
61CASK0.92386953
62STK240.92268797
63STK110.92194724
64SGK10.90910184
65DYRK30.89097061
66NEK90.87122785
67BMPR1B0.87012296
68MAPK110.85175615
69CDK70.83896658
70MAPK120.82622566
71RIPK40.79277475
72DYRK1B0.78948256
73BTK0.78129739
74RET0.77770897
75CHUK0.74285854
76EEF2K0.74197787
77KSR10.73424758
78PRKCZ0.71947396
79CAMK10.71917684
80PRKCH0.71257304
81PRKCI0.69814003
82SIK10.68412005
83RAF10.68320095
84CDC42BPA0.68010166
85MTOR0.67993145
86SYK0.67603405
87STK38L0.66217257
88CDK50.64989664
89MAP3K140.64707951
90FGFR30.64106116
91MAPK150.63811789
92WNK30.62247976
93CDK40.61988936
94OXSR10.61086531
95CDK90.59298855
96CAMK1G0.59296965
97MAPK70.57686170
98ZAK0.56994847
99BRSK20.55768810
100MKNK20.55727034
101FGFR20.54884420
102CDK20.52255592
103SMG10.50783551
104EPHA20.50135205
105PLK30.48884372
106BLK0.48654245
107AURKB0.46889203
108TAOK10.46178613
109CDK10.46010924
110STK40.44368071
111RPS6KA30.43920140
112PDK10.43141307
113IKBKE0.42738099
114RPS6KB10.38723075
115AKT30.37520507
116CLK10.35644955
117MAP3K40.35479752
118AURKA0.34239390
119PAK10.34149117
120CSNK1D0.34055588
121PRKDC0.30154854
122MKNK10.28798286
123TSSK60.28139964
124GSK3B0.28078032
125PAK40.27619295
126NEK60.26314705
127PINK10.26162876
128TESK20.25976869
129RPS6KB20.25239389
130LATS10.25116226
131CSNK2A20.24611085
132MET0.23116851
133CSNK2A10.22003274
134TLK10.21829778
135PIM10.21516695
136BRAF0.20745588
137MAPK140.19904365
138PAK20.19694221
139CDK30.19174933
140PRKAA10.18850281
141BRSK10.17645656
142YES10.17409707
143CDK60.17179044
144NTRK20.17031066
145CSNK1E0.16207414
146VRK10.16002268
147EIF2AK10.15778152
148MAPK80.15296620
149MAPK10.14494795
150TGFBR10.12841418
151IRAK10.11462605
152NEK10.10623557
153MARK30.09710222
154AKT10.09573137
155PRKACB0.08046905
156MAPK100.07269492
157RPS6KA10.06111621
158DYRK1A0.06059491
159RPS6KA50.05923775
160MELK0.04835585

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034604.28557240
2Basal transcription factors_Homo sapiens_hsa030223.94604369
3RNA transport_Homo sapiens_hsa030133.37396375
4Homologous recombination_Homo sapiens_hsa034402.96599502
5Vitamin B6 metabolism_Homo sapiens_hsa007502.91291789
6mRNA surveillance pathway_Homo sapiens_hsa030152.88332880
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.88141411
8DNA replication_Homo sapiens_hsa030302.86484030
9Dorso-ventral axis formation_Homo sapiens_hsa043202.64733336
10Mismatch repair_Homo sapiens_hsa034302.63976722
11Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.44640025
12Selenocompound metabolism_Homo sapiens_hsa004502.29515912
13Cell cycle_Homo sapiens_hsa041102.26949215
14Spliceosome_Homo sapiens_hsa030402.24890950
15Pyruvate metabolism_Homo sapiens_hsa006202.22426467
16B cell receptor signaling pathway_Homo sapiens_hsa046622.07016530
17Nucleotide excision repair_Homo sapiens_hsa034202.05997670
18Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.99867304
19Fatty acid biosynthesis_Homo sapiens_hsa000611.98070757
20Base excision repair_Homo sapiens_hsa034101.96376853
21Non-homologous end-joining_Homo sapiens_hsa034501.88275716
22* Oocyte meiosis_Homo sapiens_hsa041141.85007684
23mTOR signaling pathway_Homo sapiens_hsa041501.76543389
24RNA degradation_Homo sapiens_hsa030181.71322007
25Pentose phosphate pathway_Homo sapiens_hsa000301.69481131
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.67068702
27Linoleic acid metabolism_Homo sapiens_hsa005911.64582118
28Glucagon signaling pathway_Homo sapiens_hsa049221.63626792
29Nicotine addiction_Homo sapiens_hsa050331.60297289
30ErbB signaling pathway_Homo sapiens_hsa040121.59679065
31Circadian rhythm_Homo sapiens_hsa047101.55224020
32Non-small cell lung cancer_Homo sapiens_hsa052231.51891627
33Pyrimidine metabolism_Homo sapiens_hsa002401.43715040
34Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.43697984
35Antigen processing and presentation_Homo sapiens_hsa046121.36627143
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.34796716
37Endometrial cancer_Homo sapiens_hsa052131.33609843
38Purine metabolism_Homo sapiens_hsa002301.32157527
39Systemic lupus erythematosus_Homo sapiens_hsa053221.28610593
40Acute myeloid leukemia_Homo sapiens_hsa052211.27758559
41Primary immunodeficiency_Homo sapiens_hsa053401.27393678
42RNA polymerase_Homo sapiens_hsa030201.23532970
43Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.23134296
44Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.22959854
45FoxO signaling pathway_Homo sapiens_hsa040681.19895948
46Ovarian steroidogenesis_Homo sapiens_hsa049131.19885423
47Glycerolipid metabolism_Homo sapiens_hsa005611.17892688
48Cholinergic synapse_Homo sapiens_hsa047251.17845940
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.16629351
50T cell receptor signaling pathway_Homo sapiens_hsa046601.16085619
51Huntingtons disease_Homo sapiens_hsa050161.15344100
52Phospholipase D signaling pathway_Homo sapiens_hsa040721.14930304
53Proteasome_Homo sapiens_hsa030501.14646831
54Type II diabetes mellitus_Homo sapiens_hsa049301.14397083
55Neurotrophin signaling pathway_Homo sapiens_hsa047221.13846790
56Choline metabolism in cancer_Homo sapiens_hsa052311.13804660
57Intestinal immune network for IgA production_Homo sapiens_hsa046721.12703443
58Chronic myeloid leukemia_Homo sapiens_hsa052201.11805187
59Morphine addiction_Homo sapiens_hsa050321.10810805
60Cysteine and methionine metabolism_Homo sapiens_hsa002701.10560385
61Renal cell carcinoma_Homo sapiens_hsa052111.07584878
62p53 signaling pathway_Homo sapiens_hsa041151.07291822
63Glioma_Homo sapiens_hsa052141.07103700
64Propanoate metabolism_Homo sapiens_hsa006401.06426013
65One carbon pool by folate_Homo sapiens_hsa006701.05243452
66Aldosterone synthesis and secretion_Homo sapiens_hsa049251.04308683
67Oxytocin signaling pathway_Homo sapiens_hsa049211.03820930
68Glutamatergic synapse_Homo sapiens_hsa047241.02938454
69Prolactin signaling pathway_Homo sapiens_hsa049171.02605695
70Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.01878961
71Colorectal cancer_Homo sapiens_hsa052100.99586024
72Circadian entrainment_Homo sapiens_hsa047130.98045358
73Pancreatic cancer_Homo sapiens_hsa052120.97886933
74Olfactory transduction_Homo sapiens_hsa047400.95189313
75MAPK signaling pathway_Homo sapiens_hsa040100.95092329
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.94932477
77Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.94779368
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.94646278
79Viral carcinogenesis_Homo sapiens_hsa052030.92185772
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.89907951
81Calcium signaling pathway_Homo sapiens_hsa040200.89381954
82Epstein-Barr virus infection_Homo sapiens_hsa051690.88338014
83Fructose and mannose metabolism_Homo sapiens_hsa000510.85909859
84GABAergic synapse_Homo sapiens_hsa047270.85601785
85Insulin signaling pathway_Homo sapiens_hsa049100.84954621
86Long-term depression_Homo sapiens_hsa047300.82805298
87Hedgehog signaling pathway_Homo sapiens_hsa043400.79826231
88GnRH signaling pathway_Homo sapiens_hsa049120.79322344
89Hepatitis B_Homo sapiens_hsa051610.77217329
90Herpes simplex infection_Homo sapiens_hsa051680.77057081
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76004399
92Taste transduction_Homo sapiens_hsa047420.75677437
93cAMP signaling pathway_Homo sapiens_hsa040240.75330428
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73521642
95Gap junction_Homo sapiens_hsa045400.72103228
96Autoimmune thyroid disease_Homo sapiens_hsa053200.71322796
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71084458
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.69943954
99NF-kappa B signaling pathway_Homo sapiens_hsa040640.69348463
100Allograft rejection_Homo sapiens_hsa053300.68183575
101Insulin resistance_Homo sapiens_hsa049310.67745663
102Osteoclast differentiation_Homo sapiens_hsa043800.67565246
103Chemokine signaling pathway_Homo sapiens_hsa040620.66725135
104Alcoholism_Homo sapiens_hsa050340.66618853
105Ras signaling pathway_Homo sapiens_hsa040140.65612126
106Ether lipid metabolism_Homo sapiens_hsa005650.64336942
107Lysine degradation_Homo sapiens_hsa003100.64126258
108Basal cell carcinoma_Homo sapiens_hsa052170.63779034
109Jak-STAT signaling pathway_Homo sapiens_hsa046300.63617456
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.62510358
111HTLV-I infection_Homo sapiens_hsa051660.62331079
112Insulin secretion_Homo sapiens_hsa049110.61939820
113Regulation of autophagy_Homo sapiens_hsa041400.59739969
114Amphetamine addiction_Homo sapiens_hsa050310.59163248
115Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58863839
116Mineral absorption_Homo sapiens_hsa049780.58405077
117Legionellosis_Homo sapiens_hsa051340.58336537
118Dopaminergic synapse_Homo sapiens_hsa047280.57973597
119Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.57363934
120Gastric acid secretion_Homo sapiens_hsa049710.55797960
121Axon guidance_Homo sapiens_hsa043600.54890458
122Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.54835605
123Biosynthesis of amino acids_Homo sapiens_hsa012300.52708517
124Influenza A_Homo sapiens_hsa051640.50666705
125Carbon metabolism_Homo sapiens_hsa012000.50576858
126Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50030616
127Wnt signaling pathway_Homo sapiens_hsa043100.45266082
128Arachidonic acid metabolism_Homo sapiens_hsa005900.44820473
129Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43576096
130Glutathione metabolism_Homo sapiens_hsa004800.41027721
131Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41020146
132Inositol phosphate metabolism_Homo sapiens_hsa005620.40489255
133Glycosaminoglycan degradation_Homo sapiens_hsa005310.35240601
134Renin secretion_Homo sapiens_hsa049240.34456460
135Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34394030
136Estrogen signaling pathway_Homo sapiens_hsa049150.34249165
137Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32905375
138Notch signaling pathway_Homo sapiens_hsa043300.32781593
139ABC transporters_Homo sapiens_hsa020100.32357562
140N-Glycan biosynthesis_Homo sapiens_hsa005100.31914555
141TGF-beta signaling pathway_Homo sapiens_hsa043500.31832342
142Tight junction_Homo sapiens_hsa045300.29835562
143Hippo signaling pathway_Homo sapiens_hsa043900.29125195
144Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.27692922
145AMPK signaling pathway_Homo sapiens_hsa041520.23895236
146Fat digestion and absorption_Homo sapiens_hsa049750.23489598
147Long-term potentiation_Homo sapiens_hsa047200.22162354
148PPAR signaling pathway_Homo sapiens_hsa033200.21032803
149HIF-1 signaling pathway_Homo sapiens_hsa040660.20569560
150Adherens junction_Homo sapiens_hsa045200.19727984
151Endocytosis_Homo sapiens_hsa041440.17849142
152Renin-angiotensin system_Homo sapiens_hsa046140.15981195
153Small cell lung cancer_Homo sapiens_hsa052220.15672969
154cGMP-PKG signaling pathway_Homo sapiens_hsa040220.15309135
155VEGF signaling pathway_Homo sapiens_hsa043700.15203602
156Measles_Homo sapiens_hsa051620.14497870
157Vitamin digestion and absorption_Homo sapiens_hsa049770.13859492
158Sphingolipid metabolism_Homo sapiens_hsa006000.12596483
159Longevity regulating pathway - mammal_Homo sapiens_hsa042110.11166647
160Cardiac muscle contraction_Homo sapiens_hsa042600.10586227
161Prostate cancer_Homo sapiens_hsa052150.09976086
162Metabolic pathways_Homo sapiens_hsa011000.09274126
163MicroRNAs in cancer_Homo sapiens_hsa052060.08143056

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