STAB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 15 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to bind and endocytose ligands such as hyaluronan, low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein has been shown to cycle between the plasma membrane and lysosomes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epoxygenase P450 pathway (GO:0019373)9.55917415
2opsonization (GO:0008228)6.98499373
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.60797006
4L-phenylalanine catabolic process (GO:0006559)6.60797006
5L-phenylalanine metabolic process (GO:0006558)6.30716799
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.30716799
7negative regulation of fibrinolysis (GO:0051918)6.16915875
8oxidative demethylation (GO:0070989)6.12816677
9drug metabolic process (GO:0017144)6.12671344
10complement activation (GO:0006956)6.06598471
11complement activation, classical pathway (GO:0006958)5.94612258
12aromatic amino acid family catabolic process (GO:0009074)5.87635987
13triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.68350156
14regulation of fibrinolysis (GO:0051917)5.64813934
15regulation of humoral immune response (GO:0002920)5.62064811
16killing of cells in other organism involved in symbiotic interaction (GO:0051883)5.56993264
17disruption of cells of other organism involved in symbiotic interaction (GO:0051818)5.56993264
18high-density lipoprotein particle remodeling (GO:0034375)5.48865844
19negative regulation of protein activation cascade (GO:2000258)5.44473230
20protein carboxylation (GO:0018214)5.31266797
21peptidyl-glutamic acid carboxylation (GO:0017187)5.31266797
22indole-containing compound catabolic process (GO:0042436)5.26100368
23indolalkylamine catabolic process (GO:0046218)5.26100368
24tryptophan catabolic process (GO:0006569)5.26100368
25bile acid biosynthetic process (GO:0006699)5.25392234
26kynurenine metabolic process (GO:0070189)5.23507885
27lymph vessel development (GO:0001945)5.22947732
28alpha-linolenic acid metabolic process (GO:0036109)5.19351076
29cytolysis (GO:0019835)5.19342490
30glyoxylate metabolic process (GO:0046487)5.12327146
31regulation of protein activation cascade (GO:2000257)5.06673494
32tryptophan metabolic process (GO:0006568)4.98183427
33urea metabolic process (GO:0019627)4.91103583
34urea cycle (GO:0000050)4.91103583
35reverse cholesterol transport (GO:0043691)4.88269089
36complement activation, alternative pathway (GO:0006957)4.76660020
37lymphangiogenesis (GO:0001946)4.74436579
38regulation of complement activation (GO:0030449)4.74011790
39positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.67582741
40sulfur amino acid catabolic process (GO:0000098)4.59371075
41protein-lipid complex remodeling (GO:0034368)4.59352593
42macromolecular complex remodeling (GO:0034367)4.59352593
43plasma lipoprotein particle remodeling (GO:0034369)4.59352593
44glucuronate metabolic process (GO:0019585)4.59093872
45uronic acid metabolic process (GO:0006063)4.59093872
46bile acid metabolic process (GO:0008206)4.50162765
47fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.49917061
48nitrogen cycle metabolic process (GO:0071941)4.47345175
49cysteine metabolic process (GO:0006534)4.45332939
50triglyceride homeostasis (GO:0070328)4.39563488
51acylglycerol homeostasis (GO:0055090)4.39563488
52regulation of cholesterol esterification (GO:0010872)4.38736114
53serine family amino acid catabolic process (GO:0009071)4.33354739
54negative regulation of complement activation (GO:0045916)4.29620950
55plasma lipoprotein particle clearance (GO:0034381)4.26212972
56phospholipid efflux (GO:0033700)4.24070462
57ethanol metabolic process (GO:0006067)4.23881259
58regulation of triglyceride catabolic process (GO:0010896)4.23839642
59aromatic amino acid family metabolic process (GO:0009072)4.22698991
60drug catabolic process (GO:0042737)4.18095075
61regulation of plasminogen activation (GO:0010755)4.16355214
62tyrosine metabolic process (GO:0006570)4.11428227
63homocysteine metabolic process (GO:0050667)4.10406664
64vascular endothelial growth factor signaling pathway (GO:0038084)4.08436603
65blood coagulation, intrinsic pathway (GO:0007597)4.04615600
66alpha-amino acid catabolic process (GO:1901606)4.04297021
67arginine metabolic process (GO:0006525)4.03406967
68lysine metabolic process (GO:0006553)4.03074424
69lysine catabolic process (GO:0006554)4.03074424
70negative regulation of cholesterol transport (GO:0032375)4.02742034
71negative regulation of sterol transport (GO:0032372)4.02742034
72phospholipid homeostasis (GO:0055091)3.99174161
73amino-acid betaine metabolic process (GO:0006577)3.97662753
74cholesterol efflux (GO:0033344)3.97540488
75bile acid and bile salt transport (GO:0015721)3.91430080
76protein activation cascade (GO:0072376)3.90405550
77fibrinolysis (GO:0042730)3.88801249
78cellular ketone body metabolic process (GO:0046950)3.86851708
79plasma lipoprotein particle assembly (GO:0034377)3.85052561
80exogenous drug catabolic process (GO:0042738)3.80943849
81indolalkylamine metabolic process (GO:0006586)3.72543497
82flavonoid metabolic process (GO:0009812)3.71470302
83sodium-independent organic anion transport (GO:0043252)3.68930311
84coenzyme catabolic process (GO:0009109)3.68589493
85cellular amino acid catabolic process (GO:0009063)3.68003726
86glycine metabolic process (GO:0006544)3.66488103
87negative regulation of lipase activity (GO:0060192)3.66189405
88benzene-containing compound metabolic process (GO:0042537)3.65842948
89glutamate metabolic process (GO:0006536)3.64992689
90phenylpropanoid metabolic process (GO:0009698)3.63447330
91imidazole-containing compound metabolic process (GO:0052803)3.62724629
92low-density lipoprotein particle remodeling (GO:0034374)3.61294408
93cholesterol homeostasis (GO:0042632)3.57800222
94transcytosis (GO:0045056)3.57481233
95disruption of cells of other organism (GO:0044364)3.57456573
96killing of cells of other organism (GO:0031640)3.57456573
97plasma lipoprotein particle organization (GO:0071827)3.55208461
98regulation of female gonad development (GO:2000194)3.53888913
99amine catabolic process (GO:0009310)3.52328129
100cellular biogenic amine catabolic process (GO:0042402)3.52328129
101protein-lipid complex assembly (GO:0065005)3.51748486
102negative regulation of hemostasis (GO:1900047)3.51473975
103negative regulation of blood coagulation (GO:0030195)3.51473975
104dicarboxylic acid biosynthetic process (GO:0043650)3.51407798
105sterol homeostasis (GO:0055092)3.51134934
106cellular glucuronidation (GO:0052695)3.50508722
107negative regulation of coagulation (GO:0050819)3.50259168
108regulation of acute inflammatory response (GO:0002673)3.49336475
109positive regulation of triglyceride lipase activity (GO:0061365)3.48371952
110positive regulation of lipoprotein lipase activity (GO:0051006)3.48371952
111positive regulation of protein kinase C signaling (GO:0090037)3.46890355
112cellular modified amino acid catabolic process (GO:0042219)3.46375161
113very-low-density lipoprotein particle assembly (GO:0034379)3.45983354
114negative regulation of wound healing (GO:0061045)3.44485397
115regulation of cholesterol homeostasis (GO:2000188)3.43816717
116acute inflammatory response (GO:0002526)3.43016275
117hormone catabolic process (GO:0042447)3.42509707
118serine family amino acid metabolic process (GO:0009069)3.42487225
119cholesterol catabolic process (GO:0006707)3.39488782
120sterol catabolic process (GO:0016127)3.39488782
121protein-lipid complex subunit organization (GO:0071825)3.37796037
122negative regulation of humoral immune response (GO:0002921)3.36022926
123positive regulation of hemostasis (GO:1900048)3.34917738
124positive regulation of blood coagulation (GO:0030194)3.34917738
125S-adenosylmethionine metabolic process (GO:0046500)3.33776621
126acute-phase response (GO:0006953)3.33685513
127ethanol oxidation (GO:0006069)3.31801103
128positive regulation of lipid catabolic process (GO:0050996)3.31008125
129aldehyde catabolic process (GO:0046185)3.30379206
130ketone body metabolic process (GO:1902224)3.30168963
131regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.29750135
132regulation of acrosome reaction (GO:0060046)3.27569650
133arginine catabolic process (GO:0006527)3.15659216
134multicellular organism reproduction (GO:0032504)3.15101545
135regulation of apoptotic cell clearance (GO:2000425)3.13936859
136alkaloid metabolic process (GO:0009820)3.11628224
137xenobiotic metabolic process (GO:0006805)3.08614694
138drug transmembrane transport (GO:0006855)3.06666320
139intestinal cholesterol absorption (GO:0030299)3.03253524
140regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.02931960
141omega-hydroxylase P450 pathway (GO:0097267)10.4769067

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.51197255
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.45479661
3* LXR_22158963_ChIP-Seq_LIVER_Mouse5.97997207
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.63953159
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.28524038
6* FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.86007415
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.19550831
8BP1_19119308_ChIP-ChIP_Hs578T_Human4.03073730
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.71490522
10EZH2_22144423_ChIP-Seq_EOC_Human3.31465392
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.18806725
12CLOCK_20551151_ChIP-Seq_293T_Human2.61242050
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.14056879
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.07138169
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.5903144
16GBX2_23144817_ChIP-Seq_PC3_Human1.90919176
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.77130701
18GATA2_21666600_ChIP-Seq_HMVEC_Human1.72307749
19TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71087247
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.67893161
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67796309
22HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.59786972
23TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.59189890
24BCAT_22108803_ChIP-Seq_LS180_Human1.58854162
25* FOXA2_19822575_ChIP-Seq_HepG2_Human1.53845221
26ER_23166858_ChIP-Seq_MCF-7_Human1.50241255
27GATA1_22025678_ChIP-Seq_K562_Human1.46668173
28UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43378063
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.42898364
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41328951
31ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.40231327
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.37029674
33STAT3_23295773_ChIP-Seq_U87_Human1.35551829
34* CBP_20019798_ChIP-Seq_JUKART_Human1.34742575
35* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34742575
36BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.33795082
37AR_21572438_ChIP-Seq_LNCaP_Human1.33733367
38TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.31992907
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.30044281
40SMAD4_21741376_ChIP-Seq_EPCs_Human1.28419022
41* DROSHA_22980978_ChIP-Seq_HELA_Human1.27772577
42IGF1R_20145208_ChIP-Seq_DFB_Human1.27583335
43STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.27373417
44* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.27217069
45GATA1_19941826_ChIP-Seq_K562_Human1.26780953
46VDR_22108803_ChIP-Seq_LS180_Human1.26057566
47AR_25329375_ChIP-Seq_VCAP_Human1.24946372
48SALL4_18804426_ChIP-ChIP_XEN_Mouse1.23845462
49GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.23258572
50RARG_19884340_ChIP-ChIP_MEFs_Mouse1.20528029
51NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.19974334
52* TCF4_23295773_ChIP-Seq_U87_Human1.19152787
53PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.18950367
54E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.18936133
55SMAD4_21799915_ChIP-Seq_A2780_Human1.18664428
56* HNF4A_19822575_ChIP-Seq_HepG2_Human1.17396610
57TP53_18474530_ChIP-ChIP_U2OS_Human1.17082533
58TBL1_22424771_ChIP-Seq_293T_Human1.15939234
59CDX2_22108803_ChIP-Seq_LS180_Human1.15672323
60POU3F2_20337985_ChIP-ChIP_501MEL_Human1.15496306
61PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.14208060
62HNFA_21074721_ChIP-Seq_CACO-2_Human1.14133653
63CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.12468437
64* RUNX2_22187159_ChIP-Seq_PCA_Human1.11878917
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11850538
66POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11850538
67* NFYA_21822215_ChIP-Seq_K562_Human1.11690728
68ZNF263_19887448_ChIP-Seq_K562_Human1.11386524
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11164640
70EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.10812459
71ESR2_21235772_ChIP-Seq_MCF-7_Human1.10800721
72EP300_21415370_ChIP-Seq_HL-1_Mouse1.10466349
73CJUN_26792858_Chip-Seq_BT549_Human1.10040130
74PHF8_20622853_ChIP-Seq_HELA_Human1.07312043
75TAF15_26573619_Chip-Seq_HEK293_Human1.06215501
76ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05627245
77SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05575804
78* GF1_26923725_Chip-Seq_HPCs_Mouse1.05349698
79NFYB_21822215_ChIP-Seq_K562_Human1.04758597
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.04030603
81* LXR_22292898_ChIP-Seq_THP-1_Human1.03321058
82RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.02606144
83IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.01471978
84ARNT_22903824_ChIP-Seq_MCF-7_Human1.01178645
85ELK3_25401928_ChIP-Seq_HUVEC_Human0.99998996
86TCF4_18268006_ChIP-ChIP_LS174T_Human0.98811630
87SMAD4_21741376_ChIP-Seq_HESCs_Human0.97578628
88ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97559195
89NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.96642406
90NANOG_19829295_ChIP-Seq_ESCs_Human0.95818375
91SOX2_19829295_ChIP-Seq_ESCs_Human0.95818375
92TCF4_22108803_ChIP-Seq_LS180_Human0.95272183
93PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.95198074
94ETV1_20927104_ChIP-Seq_GIST48_Human0.95147898
95* TP63_23658742_ChIP-Seq_EP156T_Human0.94956304
96ESR1_20079471_ChIP-ChIP_T-47D_Human0.94891784
97* RAC3_21632823_ChIP-Seq_H3396_Human0.93596568
98P300_19829295_ChIP-Seq_ESCs_Human0.92474598
99NANOG_20526341_ChIP-Seq_ESCs_Human0.91775249
100CBX2_22325352_ChIP-Seq_293T-Rex_Human0.91079438
101ESR1_21235772_ChIP-Seq_MCF-7_Human0.90201297
102RXRA_24833708_ChIP-Seq_LIVER_Mouse0.89813914
103TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89552907
104TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89177779
105CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.88894081
106* OCT1_27270436_Chip-Seq_PROSTATE_Human0.88371824
107FOXH1_21741376_ChIP-Seq_EPCs_Human0.87754604
108* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.87577927
109PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.87417657
110TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87411635
111HTT_18923047_ChIP-ChIP_STHdh_Human0.87375532
112FOXA1_21572438_ChIP-Seq_LNCaP_Human0.86364585
113AHR_22903824_ChIP-Seq_MCF-7_Human0.86355802
114PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.85855656
115TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.85646192
116GATA3_21878914_ChIP-Seq_MCF-7_Human0.85506959
117* GATA1_19941827_ChIP-Seq_MEL_Mouse0.81791795
118PPAR_26484153_Chip-Seq_NCI-H1993_Human0.77257120
119SOX2_27498859_Chip-Seq_STOMACH_Mouse0.76572895
120POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.74539334
121ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.74182706
122ESR1_15608294_ChIP-ChIP_MCF-7_Human0.74019385
123GATA2_19941826_ChIP-Seq_K562_Human0.73061512
124CDX2_20551321_ChIP-Seq_CACO-2_Human0.73002141
125STAT3_1855785_ChIP-Seq_MESCs_Mouse0.69938183
126BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.69518429
127PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.68962736
128NFIB_24661679_ChIP-Seq_LUNG_Mouse0.68367964
129NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.68098761
130Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.66822272
131PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.66562090
132AUTS2_25519132_ChIP-Seq_293T-REX_Human0.66041030
133* GATA4_25053715_ChIP-Seq_YYC3_Human0.63656259
134RACK7_27058665_Chip-Seq_MCF-7_Human0.63531838
135FOXO3_23340844_ChIP-Seq_DLD1_Human0.62099555
136FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.61700259
137NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.61233048
138NRF2_20460467_ChIP-Seq_MEFs_Mouse0.61233048
139ERG_21242973_ChIP-ChIP_JURKAT_Human0.60874268
140IRF8_22096565_ChIP-ChIP_GC-B_Human0.60020280
141TBX20_22328084_ChIP-Seq_HEART_Mouse0.59979387
142TBX20_22080862_ChIP-Seq_HEART_Mouse0.59979387
143SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.59595457
144SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.59391584
145RARB_24833708_ChIP-Seq_LIVER_Mouse0.59248268
146SOX2_20726797_ChIP-Seq_SW620_Human0.59058132
147AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.57898180
148KDM2B_26808549_Chip-Seq_SUP-B15_Human0.56924046
149RARA_24833708_ChIP-Seq_LIVER_Mouse0.56573894
150RAD21_21589869_ChIP-Seq_MESCs_Mouse0.56442840
151CTCF_20526341_ChIP-Seq_ESCs_Human0.56376127
152DNAJC2_21179169_ChIP-ChIP_NT2_Human0.56198759
153SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.56136311
154GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.55182507
155SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.54171734
156RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.53778912
157CEBPB_22108803_ChIP-Seq_LS180_Human0.53081690
158CTCF_27219007_Chip-Seq_Bcells_Human0.52344851
159ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.51418183
160TRIM28_21343339_ChIP-Seq_HEK293_Human0.51208800
161FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.49922875
162SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.49752098
163FOXA1_25552417_ChIP-Seq_VCAP_Human0.48491999
164CBP_21632823_ChIP-Seq_H3396_Human0.48484724
165ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.48028068
166SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.46813096
167NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.45864624
168BRD4_27068464_Chip-Seq_AML-cells_Mouse0.44225279
169CTCF_21964334_ChIP-Seq_BJAB-B_Human0.43821340
170SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.43219299
171MYC_19915707_ChIP-ChIP_AK7_Human0.43128019
172ELF1_20517297_ChIP-Seq_JURKAT_Human0.43097087
173* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.43010619

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system7.48155257
2MP0002139_abnormal_hepatobiliary_system6.27664253
3MP0005360_urolithiasis5.83272687
4MP0005085_abnormal_gallbladder_physiolo4.96400741
5MP0005365_abnormal_bile_salt4.79303355
6MP0001879_abnormal_lymphatic_vessel4.20080034
7MP0008875_abnormal_xenobiotic_pharmacok3.71171594
8MP0003724_increased_susceptibility_to3.12160338
9MP0010329_abnormal_lipoprotein_level3.04688776
10MP0006054_spinal_hemorrhage3.03641517
11MP0003252_abnormal_bile_duct2.97937000
12MP0005410_abnormal_fertilization2.93020058
13MP0003806_abnormal_nucleotide_metabolis2.83291751
14MP0000013_abnormal_adipose_tissue2.51038992
15MP0009840_abnormal_foam_cell2.45275340
16MP0005083_abnormal_biliary_tract2.42920304
17MP0002138_abnormal_hepatobiliary_system2.15377058
18MP0004272_abnormal_basement_membrane2.13066096
19MP0008004_abnormal_stomach_pH2.12610362
20MP0003191_abnormal_cellular_cholesterol2.10216521
21MP0005332_abnormal_amino_acid1.93127476
22MP0000609_abnormal_liver_physiology1.92192459
23MP0005167_abnormal_blood-brain_barrier1.92112701
24MP0001666_abnormal_nutrient_absorption1.86588199
25MP0003300_gastrointestinal_ulcer1.83671131
26MP0004019_abnormal_vitamin_homeostasis1.78387170
27MP0003195_calcinosis1.76962168
28MP0002132_abnormal_respiratory_system1.67168269
29MP0008438_abnormal_cutaneous_collagen1.66808696
30MP0005319_abnormal_enzyme/_coenzyme1.63364497
31MP0005275_abnormal_skin_tensile1.62077531
32MP0002118_abnormal_lipid_homeostasis1.61177441
33MP0003718_maternal_effect1.60109690
34MP0009697_abnormal_copulation1.59393649
35MP0003950_abnormal_plasma_membrane1.45599884
36MP0005395_other_phenotype1.32226499
37MP0009053_abnormal_anal_canal1.27994107
38MP0003868_abnormal_feces_composition1.27485120
39MP0004130_abnormal_muscle_cell1.21767314
40MP0005584_abnormal_enzyme/coenzyme_acti1.15898809
41MP0000598_abnormal_liver_morphology1.15850437
42MP0002282_abnormal_trachea_morphology1.11731932
43MP0001851_eye_inflammation1.11605784
44MP0005670_abnormal_white_adipose1.10336064
45MP0009764_decreased_sensitivity_to1.09085310
46MP0009763_increased_sensitivity_to1.07569013
47MP0003705_abnormal_hypodermis_morpholog1.06082601
48MP0001929_abnormal_gametogenesis1.03035294
49MP0003011_delayed_dark_adaptation1.02915943
50MP0000465_gastrointestinal_hemorrhage1.01274935
51MP0001764_abnormal_homeostasis0.97414932
52MP0003656_abnormal_erythrocyte_physiolo0.96952982
53MP0003698_abnormal_male_reproductive0.95358551
54MP0005647_abnormal_sex_gland0.95262452
55MP0001915_intracranial_hemorrhage0.94849694
56MP0005503_abnormal_tendon_morphology0.94506043
57MP0009643_abnormal_urine_homeostasis0.92995794
58MP0005023_abnormal_wound_healing0.92620081
59MP0000678_abnormal_parathyroid_gland0.91758237
60MP0008469_abnormal_protein_level0.91203304
61MP0003879_abnormal_hair_cell0.89089945
62MP0004264_abnormal_extraembryonic_tissu0.88994969
63MP0000604_amyloidosis0.87368113
64MP0005451_abnormal_body_composition0.86716744
65MP0001986_abnormal_taste_sensitivity0.86157759
66MP0000003_abnormal_adipose_tissue0.85877519
67MP0005636_abnormal_mineral_homeostasis0.85774017
68MP0002249_abnormal_larynx_morphology0.85037133
69MP0001661_extended_life_span0.84987441
70MP0003186_abnormal_redox_activity0.84137852
71MP0002168_other_aberrant_phenotype0.83918185
72MP0002254_reproductive_system_inflammat0.83250282
73MP0005595_abnormal_vascular_smooth0.82919356
74MP0009765_abnormal_xenobiotic_induced0.81720126
75MP0002108_abnormal_muscle_morphology0.80683076
76MP0002332_abnormal_exercise_endurance0.79532842
77MP0000249_abnormal_blood_vessel0.73868911
78MP0003878_abnormal_ear_physiology0.73696462
79MP0005377_hearing/vestibular/ear_phenot0.73696462
80MP0005376_homeostasis/metabolism_phenot0.72795245
81MP0003303_peritoneal_inflammation0.72636781
82MP0005409_darkened_coat_color0.72024932
83MP0002876_abnormal_thyroid_physiology0.71807456
84MP0008872_abnormal_physiological_respon0.70939491
85MP0009642_abnormal_blood_homeostasis0.70692098
86MP0004215_abnormal_myocardial_fiber0.69575981
87MP0009115_abnormal_fat_cell0.68902161
88MP0002161_abnormal_fertility/fecundity0.68490890
89MP0003690_abnormal_glial_cell0.68152250
90MP0005165_increased_susceptibility_to0.67082308
91MP0001243_abnormal_dermal_layer0.64110028
92MP0008057_abnormal_DNA_replication0.63511815
93MP0005164_abnormal_response_to0.63020232
94MP0000767_abnormal_smooth_muscle0.62393604
95MP0008874_decreased_physiological_sensi0.61166894
96MP0002128_abnormal_blood_circulation0.60954262
97MP0005397_hematopoietic_system_phenotyp0.60874734
98MP0001545_abnormal_hematopoietic_system0.60874734
99MP0002078_abnormal_glucose_homeostasis0.60786867
100MP0005187_abnormal_penis_morphology0.60523930
101MP0001873_stomach_inflammation0.58994058
102MP0004510_myositis0.58945477
103MP0003699_abnormal_female_reproductive0.58099650
104MP0004147_increased_porphyrin_level0.57362367
105MP0003638_abnormal_response/metabolism_0.56746860
106MP0005464_abnormal_platelet_physiology0.56724154
107MP0005334_abnormal_fat_pad0.56238275
108MP0002295_abnormal_pulmonary_circulatio0.55611031
109MP0002127_abnormal_cardiovascular_syste0.54270523
110MP0008775_abnormal_heart_ventricle0.53618125
111MP0000230_abnormal_systemic_arterial0.52991251
112MP0003646_muscle_fatigue0.52795342
113MP0004036_abnormal_muscle_relaxation0.52081590
114MP0005375_adipose_tissue_phenotype0.50475045
115MP0004782_abnormal_surfactant_physiolog0.50437609
116MP0002796_impaired_skin_barrier0.50197668
117MP0005266_abnormal_metabolism0.48975098
118MP0003890_abnormal_embryonic-extraembry0.48240090
119MP0008873_increased_physiological_sensi0.48223804
120MP0005084_abnormal_gallbladder_morpholo0.48056864
121MP0004883_abnormal_blood_vessel0.47807571
122MP0003943_abnormal_hepatobiliary_system0.46857393
123MP0000566_synostosis0.46614250
124MP0003566_abnormal_cell_adhesion0.44783692
125MP0001533_abnormal_skeleton_physiology0.44050623
126MP0005166_decreased_susceptibility_to0.43716745
127MP0005666_abnormal_adipose_tissue0.43423295
128MP0000639_abnormal_adrenal_gland0.43250690
129MP0002971_abnormal_brown_adipose0.42788189
130MP0003436_decreased_susceptibility_to0.42329664
131MP0003633_abnormal_nervous_system0.41678944
132MP0002136_abnormal_kidney_physiology0.40140883
133MP0000343_altered_response_to0.39180315
134MP0005408_hypopigmentation0.38612576
135MP0002210_abnormal_sex_determination0.37847107
136MP0002419_abnormal_innate_immunity0.37610969
137MP0001614_abnormal_blood_vessel0.37534340
138MP0003959_abnormal_lean_body0.37195933
139MP0001756_abnormal_urination0.37151700
140MP0000653_abnormal_sex_gland0.36909832
141MP0001845_abnormal_inflammatory_respons0.36383082
142MP0005535_abnormal_body_temperature0.35778183

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.95295131
2Prolonged partial thromboplastin time (HP:0003645)6.53925160
3Intrahepatic cholestasis (HP:0001406)6.47285561
4Nonimmune hydrops fetalis (HP:0001790)6.45424156
5Abnormality of aromatic amino acid family metabolism (HP:0004338)6.07948407
6Abnormality of monocarboxylic acid metabolism (HP:0010996)5.66237268
7Hypobetalipoproteinemia (HP:0003563)5.52075930
8Xanthomatosis (HP:0000991)5.49101300
9Joint hemorrhage (HP:0005261)5.27855292
10Hyperlipoproteinemia (HP:0010980)4.67969244
11Nephritis (HP:0000123)4.65267817
12Hypolipoproteinemia (HP:0010981)4.62039797
13Complement deficiency (HP:0004431)4.55870252
14Hypoalphalipoproteinemia (HP:0003233)4.43529244
15Abnormality of the intrinsic pathway (HP:0010989)4.17434246
16Abnormality of the common coagulation pathway (HP:0010990)4.17418125
17Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.16492154
18Osteomalacia (HP:0002749)3.89449048
19Hyperammonemia (HP:0001987)3.86872721
20Epidermoid cyst (HP:0200040)3.78237974
21Ketosis (HP:0001946)3.60323533
22Fat malabsorption (HP:0002630)3.56675555
23Hyperglycinemia (HP:0002154)3.45582432
24Hypoglycemic coma (HP:0001325)3.42980419
25Abnormality of sulfur amino acid metabolism (HP:0004339)3.41544902
26Esophageal varix (HP:0002040)3.40968137
27Abnormality of glutamine family amino acid metabolism (HP:0010902)3.39191863
28Abnormality of complement system (HP:0005339)3.32454747
29Abnormality of methionine metabolism (HP:0010901)3.30057617
30Abnormality of aspartate family amino acid metabolism (HP:0010899)3.25594812
31Polycythemia (HP:0001901)3.19978633
32Vascular calcification (HP:0004934)3.17274706
33Hypercholesterolemia (HP:0003124)3.15111865
34Conjugated hyperbilirubinemia (HP:0002908)3.12812390
35Hemorrhage of the eye (HP:0011885)3.07386310
36Abnormality of glycine metabolism (HP:0010895)3.04040354
37Abnormality of serine family amino acid metabolism (HP:0010894)3.04040354
38Capillary hemangiomas (HP:0005306)3.01523714
39Hyperglycinuria (HP:0003108)3.01450815
40Hyperbilirubinemia (HP:0002904)2.99206150
41Abnormality of pyrimidine metabolism (HP:0004353)2.94529212
42Lymphangioma (HP:0100764)2.92396720
43Spontaneous hematomas (HP:0007420)2.91859486
44Hepatocellular carcinoma (HP:0001402)2.85119769
45Cardiovascular calcification (HP:0011915)2.84294744
46Myocardial infarction (HP:0001658)2.77261553
47Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.75498415
48Thrombophlebitis (HP:0004418)2.69850782
49Abnormality of fatty-acid metabolism (HP:0004359)2.69469872
50Fair hair (HP:0002286)2.68531054
51Spontaneous abortion (HP:0005268)2.68299518
52Delayed CNS myelination (HP:0002188)2.68004320
53Abnormality of nucleobase metabolism (HP:0010932)2.63895431
54Ketoacidosis (HP:0001993)2.61846726
55Conjunctival telangiectasia (HP:0000524)2.60792235
56Amyloidosis (HP:0011034)2.55376168
57Acanthocytosis (HP:0001927)2.52578901
58Steatorrhea (HP:0002570)2.50192468
59Abnormality of purine metabolism (HP:0004352)2.48578540
60Skin nodule (HP:0200036)2.45883760
61Hypochromic microcytic anemia (HP:0004840)2.43987076
62Abnormal gallbladder physiology (HP:0012438)2.41468483
63Cholecystitis (HP:0001082)2.41468483
64Cerebral hemorrhage (HP:0001342)2.39278096
65Hypoglycemic seizures (HP:0002173)2.33997896
66Generalized aminoaciduria (HP:0002909)2.31414614
67Pulmonary embolism (HP:0002204)2.29798860
68Systemic lupus erythematosus (HP:0002725)2.29249479
69Abnormality of the vasculature of the conjunctiva (HP:0008054)2.28684545
70Hypophosphatemic rickets (HP:0004912)2.28422878
71Abnormal gallbladder morphology (HP:0012437)2.27528757
72Potter facies (HP:0002009)2.26725894
73Facial shape deformation (HP:0011334)2.26725894
74Cholelithiasis (HP:0001081)2.25781536
75Stroke (HP:0001297)2.23561953
76Broad metatarsal (HP:0001783)2.20270027
77Elevated alkaline phosphatase (HP:0003155)2.19350660
78Neonatal hypoglycemia (HP:0001998)2.19212382
79Abnormality of serum amino acid levels (HP:0003112)2.18913125
80Spastic diplegia (HP:0001264)2.17943763
81Dicarboxylic aciduria (HP:0003215)2.17904192
82Abnormality of dicarboxylic acid metabolism (HP:0010995)2.17904192
83Menorrhagia (HP:0000132)2.16488431
84Poikilocytosis (HP:0004447)2.16474897
85Mitral stenosis (HP:0001718)2.16370889
86Short hallux (HP:0010109)2.13919214
87Metabolic acidosis (HP:0001942)2.12957809
88Gingival bleeding (HP:0000225)2.10310474
89Azoospermia (HP:0000027)2.09761833
90Rickets (HP:0002748)2.03690508
91Cardiomegaly (HP:0001640)2.03346715
92Abnormality of the ischium (HP:0003174)2.02668758
93Sensorimotor neuropathy (HP:0007141)2.02313493
94Neonatal onset (HP:0003623)2.01948231
95Irritability (HP:0000737)2.01181093
96Aplasia/Hypoplasia of the hallux (HP:0008362)1.95241928
97Abnormality of alkaline phosphatase activity (HP:0004379)1.94833920
98Abnormality of iron homeostasis (HP:0011031)1.94451739
99Lethargy (HP:0001254)1.94395198
100Hematochezia (HP:0002573)1.93641050
101Abnormality of the gallbladder (HP:0005264)1.93034914
102Recurrent gram-negative bacterial infections (HP:0005420)1.92273629
103Gout (HP:0001997)1.92095831
104Glomerulonephritis (HP:0000099)1.91829457
105Hyperglycemia (HP:0003074)1.91055062
106Malnutrition (HP:0004395)1.90284172
107Bile duct proliferation (HP:0001408)1.88782589
108Abnormal biliary tract physiology (HP:0012439)1.88782589
109Microcytic anemia (HP:0001935)1.88689636
110Abnormality of transition element cation homeostasis (HP:0011030)1.88324756
111Generalized hypopigmentation of hair (HP:0011358)1.86579441
112Pancreatitis (HP:0001733)1.85658681
113Abnormal enzyme/coenzyme activity (HP:0012379)1.84800775
114Hyperinsulinemic hypoglycemia (HP:0000825)1.84794991
115Epistaxis (HP:0000421)1.83242700
116Chronic hepatic failure (HP:0100626)1.82084885
117Joint swelling (HP:0001386)1.80033646
118Abnormal delivery (HP:0001787)1.72551431
119Cerebral palsy (HP:0100021)1.71760058
120Aortic aneurysm (HP:0004942)1.65053662
121Purpura (HP:0000979)1.63481761
122Portal hypertension (HP:0001409)1.60859760
123Enlarged kidneys (HP:0000105)1.57776561
124Hypoplastic ischia (HP:0003175)1.57775872
125Blue irides (HP:0000635)1.56621545
126Gingivitis (HP:0000230)1.53376792
127Tubulointerstitial nephritis (HP:0001970)1.52995357
128Abnormal spermatogenesis (HP:0008669)1.51766856
12911 pairs of ribs (HP:0000878)1.49799272
130Abnormality of carpal bone ossification (HP:0006257)1.44185867
131Abnormality of the hepatic vasculature (HP:0006707)1.44023480
132Hematuria (HP:0000790)1.42103065
133Focal segmental glomerulosclerosis (HP:0000097)1.41096006
134Bifid scrotum (HP:0000048)1.40407780
135Visceral angiomatosis (HP:0100761)1.39724962
136Aortic dissection (HP:0002647)1.37802889
137Bell-shaped thorax (HP:0001591)1.35456036

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE18.55861538
2ERN13.27965091
3PLK42.86334139
4TGFBR22.78251916
5ACVR1B2.68953736
6AKT32.59066091
7DDR22.54428232
8BCKDK2.32613848
9MYLK2.23956571
10STK38L2.19596137
11NTRK32.04738259
12KDR11.7169597
13FGFR41.98832893
14KSR21.94234315
15TGFBR11.83892610
16SIK11.81159871
17MAP3K131.75064679
18BMPR1B1.73547056
19PINK11.58097487
20JAK11.57116987
21CAMK1G1.54231367
22CDK121.53249342
23STK381.52455447
24MAP3K91.51979873
25BRD41.49504321
26GRK11.38813599
27WNK11.38630928
28PIK3CA1.38386631
29MAP3K21.28989243
30MAP4K21.27530060
31TNK21.26719843
32PTK61.25754786
33PKN21.25634686
34EPHB11.25114588
35INSRR1.23113526
36PTK2B1.21048605
37NEK21.18047128
38TRPM71.13577183
39DAPK21.12784426
40JAK21.09574341
41JAK31.08656281
42TAOK31.08302994
43FLT31.05655845
44MELK1.05606792
45NLK1.05242262
46NEK61.04214847
47STK240.97031724
48TYK20.92418896
49MAP2K30.89418713
50MAP3K110.87486405
51CDK70.86984828
52LATS20.85693906
53CAMK40.85571372
54MAP2K40.85200722
55RIPK10.82711637
56ERBB40.82616375
57KIT0.81784631
58EIF2AK30.81583130
59MARK30.80349799
60MAP4K10.80150437
61PNCK0.77881015
62PRKG10.77498360
63TRIB30.76547621
64ADRBK20.75036696
65PDGFRB0.73988926
66STK30.71838996
67OBSCN0.70691732
68BLK0.69117049
69PTK20.68874624
70PRKG20.67972938
71MAPK120.66696975
72RAF10.65726499
73EEF2K0.65413510
74MAPK110.64181929
75MAPK150.64029525
76PBK0.63830952
77BRAF0.63521853
78ARAF0.63332734
79MUSK0.62865650
80STK390.59034167
81SGK20.58333071
82EPHB20.57456477
83MET0.55574080
84RET0.55030082
85MAP3K100.52437457
86FER0.50849779
87PRKAA20.49568039
88CLK10.47818997
89MAP3K10.47712504
90PIK3CG0.47530139
91CSK0.47278871
92TBK10.45702945
93PAK20.45335464
94MAP3K70.44553416
95MAPK10.43688393
96MST1R0.42030007
97MAP3K30.41968814
98MAP2K10.41705695
99FGFR20.41648467
100CSNK1D0.41571259
101KSR10.40499903
102NEK90.40045969
103MARK20.39966679
104GRK60.38681656
105EPHA30.37598623
106MAPK70.35855405
107IGF1R0.35762087
108EGFR0.34885730
109CDK90.34724072
110ROCK10.34365605
111PRKACB0.33335465
112MAPK40.32515542
113PLK20.32122628
114BRSK20.31675507
115GSK3A0.31673949
116SGK2230.31092402
117SGK4940.31092402
118SCYL20.30232500
119CDK40.30182077
120LYN0.26527484
121SRC0.25697991
122FGFR30.25382708
123ZAP700.24840543
124MAP3K140.24326569
125PRKCZ0.24241698
126PRKACG0.24080984
127PRKAA10.23949438
128PRKCH0.23830593
129ERBB20.22557041
130MAP2K20.21756888
131LATS10.20844046
132ABL20.20046726
133ITK0.19612115
134NTRK10.15880311
135CSF1R0.15860168
136CDK60.14722345
137MAP2K60.14203309
138PAK40.13422574
139TEC0.11972018
140PDPK10.11777227
141PDGFRA0.11757194
142FGFR10.11685038
143CAMK1D0.10559791
144PRKCQ0.09809809
145PDK10.09029485
146FES0.08485671
147PRKD10.08004139
148ICK0.07118035
149SGK30.06180422
150BTK0.05860938
151INSR0.05829757
152MTOR0.05820699
153PRKCD0.05646918
154STK100.05595123
155FRK0.05073262
156BMX0.04934324
157IKBKE0.04449485
158DYRK1B0.03567737
159LRRK20.03498004

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.58916617
2Nitrogen metabolism_Homo sapiens_hsa009103.87456525
3Complement and coagulation cascades_Homo sapiens_hsa046103.54212188
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.38830107
5Arginine biosynthesis_Homo sapiens_hsa002203.38700691
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.24418940
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.66566166
8Tryptophan metabolism_Homo sapiens_hsa003802.59997074
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.51594861
10Fatty acid degradation_Homo sapiens_hsa000712.46761292
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.39278678
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.25141865
13Butanoate metabolism_Homo sapiens_hsa006502.07559024
14PPAR signaling pathway_Homo sapiens_hsa033202.07097303
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.06638078
16Staphylococcus aureus infection_Homo sapiens_hsa051502.01486243
17Peroxisome_Homo sapiens_hsa041461.98018857
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.94586450
19Propanoate metabolism_Homo sapiens_hsa006401.78922802
20Fatty acid metabolism_Homo sapiens_hsa012121.77854765
21Histidine metabolism_Homo sapiens_hsa003401.77317260
22Chemical carcinogenesis_Homo sapiens_hsa052041.76238187
23Bile secretion_Homo sapiens_hsa049761.74421932
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.69432166
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.68295922
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.63779900
27ABC transporters_Homo sapiens_hsa020101.61175159
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.61162020
29Arachidonic acid metabolism_Homo sapiens_hsa005901.58310113
30beta-Alanine metabolism_Homo sapiens_hsa004101.56394876
31Retinol metabolism_Homo sapiens_hsa008301.53575144
32Caffeine metabolism_Homo sapiens_hsa002321.52733509
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.43422690
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.42730989
35Selenocompound metabolism_Homo sapiens_hsa004501.42618793
36Phenylalanine metabolism_Homo sapiens_hsa003601.41750769
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.38422355
38Tyrosine metabolism_Homo sapiens_hsa003501.24792036
39Pyruvate metabolism_Homo sapiens_hsa006201.22850204
40Fatty acid elongation_Homo sapiens_hsa000621.21815639
41Starch and sucrose metabolism_Homo sapiens_hsa005001.20790857
42Fat digestion and absorption_Homo sapiens_hsa049751.20173438
43Vitamin digestion and absorption_Homo sapiens_hsa049771.19777548
44Sulfur metabolism_Homo sapiens_hsa009201.15593031
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.15489315
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.07620963
47Biosynthesis of amino acids_Homo sapiens_hsa012301.07383713
48Carbon metabolism_Homo sapiens_hsa012001.00467764
49Folate biosynthesis_Homo sapiens_hsa007900.98242397
50Maturity onset diabetes of the young_Homo sapiens_hsa049500.96434995
51Arginine and proline metabolism_Homo sapiens_hsa003300.95229861
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.95097033
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.94410702
54Steroid biosynthesis_Homo sapiens_hsa001000.91145282
55Lysine degradation_Homo sapiens_hsa003100.83610451
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77591014
57Sulfur relay system_Homo sapiens_hsa041220.76073429
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75970060
59Vitamin B6 metabolism_Homo sapiens_hsa007500.72995547
60Cyanoamino acid metabolism_Homo sapiens_hsa004600.71091405
61African trypanosomiasis_Homo sapiens_hsa051430.65297401
62Malaria_Homo sapiens_hsa051440.64980131
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64931957
64Glycerolipid metabolism_Homo sapiens_hsa005610.63699869
65Pentose phosphate pathway_Homo sapiens_hsa000300.52992686
66Pertussis_Homo sapiens_hsa051330.49480772
67Fatty acid biosynthesis_Homo sapiens_hsa000610.45405376
68One carbon pool by folate_Homo sapiens_hsa006700.44287635
69Systemic lupus erythematosus_Homo sapiens_hsa053220.39812855
70Insulin resistance_Homo sapiens_hsa049310.39253197
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.39180297
72Glutathione metabolism_Homo sapiens_hsa004800.38297725
73Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.35318225
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.33578232
75Prion diseases_Homo sapiens_hsa050200.32859726
76Metabolic pathways_Homo sapiens_hsa011000.32089900
77Serotonergic synapse_Homo sapiens_hsa047260.31547378
78Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.29902760
79ECM-receptor interaction_Homo sapiens_hsa045120.25396116
80Mineral absorption_Homo sapiens_hsa049780.25108524
81Galactose metabolism_Homo sapiens_hsa000520.22877051
82Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.19326235
83Olfactory transduction_Homo sapiens_hsa047400.14611679
84Circadian rhythm_Homo sapiens_hsa047100.14512560
85Glucagon signaling pathway_Homo sapiens_hsa049220.09841534
86Fructose and mannose metabolism_Homo sapiens_hsa000510.08724307
87Renin-angiotensin system_Homo sapiens_hsa046140.07531015
88Glycosaminoglycan degradation_Homo sapiens_hsa005310.06798253
89Ovarian steroidogenesis_Homo sapiens_hsa049130.06751251
90Platelet activation_Homo sapiens_hsa046110.05691354
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.04567013
92AMPK signaling pathway_Homo sapiens_hsa041520.01912526
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.00840706
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.00371394
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1333682
96Aldosterone synthesis and secretion_Homo sapiens_hsa04925-0.1260486
97PI3K-Akt signaling pathway_Homo sapiens_hsa04151-0.1205627
98Calcium signaling pathway_Homo sapiens_hsa04020-0.1194636
99Dorso-ventral axis formation_Homo sapiens_hsa04320-0.1150839
100Insulin signaling pathway_Homo sapiens_hsa04910-0.1089108
101Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1078331
102Inositol phosphate metabolism_Homo sapiens_hsa00562-0.1060538
103Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.0986670
104TNF signaling pathway_Homo sapiens_hsa04668-0.0968883
105Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060-0.0934297
106Protein digestion and absorption_Homo sapiens_hsa04974-0.0912714
107TGF-beta signaling pathway_Homo sapiens_hsa04350-0.0887486
108Amoebiasis_Homo sapiens_hsa05146-0.0796949
109cGMP-PKG signaling pathway_Homo sapiens_hsa04022-0.0768019
110Rap1 signaling pathway_Homo sapiens_hsa04015-0.0766588
111Focal adhesion_Homo sapiens_hsa04510-0.0758904
112Salivary secretion_Homo sapiens_hsa04970-0.0742780
113Leukocyte transendothelial migration_Homo sapiens_hsa04670-0.0671545
114Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514-0.0667549
115Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0623108
116Linoleic acid metabolism_Homo sapiens_hsa00591-0.0574885
117Hepatitis C_Homo sapiens_hsa05160-0.0573954
118FoxO signaling pathway_Homo sapiens_hsa04068-0.0533054
119Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0480539
120Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533-0.0392563
121Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080-0.0297588
122Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0204180
123AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933-0.0102262

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