ST8SIA4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). The encoded protein, which is a member of glycosyltransferase family 29, is a type II membrane protein that may be present in the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.11444380
2positive regulation of gamma-delta T cell activation (GO:0046645)5.32382511
3regulation of B cell receptor signaling pathway (GO:0050855)5.18189475
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.85588101
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.85588101
6antigen processing and presentation of endogenous antigen (GO:0019883)4.82325807
7neutrophil activation involved in immune response (GO:0002283)4.52131550
8positive regulation of B cell differentiation (GO:0045579)4.44916199
9positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.39253764
10positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.38163868
11detection of molecule of bacterial origin (GO:0032490)4.37894690
12microglial cell activation (GO:0001774)4.34007361
13B cell receptor signaling pathway (GO:0050853)4.33820017
14regulation of B cell differentiation (GO:0045577)4.29275351
15negative regulation of interleukin-12 production (GO:0032695)4.14177387
16neutrophil activation (GO:0042119)4.09555741
17detection of other organism (GO:0098543)4.02096670
18myeloid leukocyte mediated immunity (GO:0002444)3.95335844
19positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.92502571
20cellular response to interleukin-15 (GO:0071350)3.85393573
21negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.85036951
22negative regulation of cell killing (GO:0031342)3.85036951
23regulation of interferon-beta biosynthetic process (GO:0045357)3.81561346
24negative regulation of phagocytosis (GO:0050765)3.78098021
25detection of external biotic stimulus (GO:0098581)3.72422614
26mast cell activation (GO:0045576)3.71550898
27granulocyte activation (GO:0036230)3.68560419
28B cell homeostasis (GO:0001782)3.68194745
29modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.66053227
30modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.66053227
31positive regulation by organism of defense response of other organism involved in symbiotic interact3.66053227
32modulation by symbiont of host immune response (GO:0052553)3.66053227
33positive regulation by symbiont of host defense response (GO:0052509)3.66053227
34modulation by symbiont of host defense response (GO:0052031)3.66053227
35negative regulation of lymphocyte mediated immunity (GO:0002707)3.65431597
36macrophage activation (GO:0042116)3.61919539
37immunoglobulin mediated immune response (GO:0016064)3.60844615
38regulation of interleukin-12 biosynthetic process (GO:0045075)3.60527420
39regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.49841920
40defense response to protozoan (GO:0042832)3.49445513
41regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.48284877
42activated T cell proliferation (GO:0050798)3.47902315
43detection of bacterium (GO:0016045)3.46013129
44cellular extravasation (GO:0045123)3.42841200
45regulation of gamma-delta T cell differentiation (GO:0045586)3.42819412
46negative regulation of T cell mediated immunity (GO:0002710)3.41782301
47myeloid dendritic cell activation (GO:0001773)3.41623123
48T cell migration (GO:0072678)3.40102258
49regulation of gamma-delta T cell activation (GO:0046643)3.38579476
50positive regulation of interferon-alpha production (GO:0032727)3.38219629
51cellular response to zinc ion (GO:0071294)3.36521199
52mature B cell differentiation (GO:0002335)3.35297524
53NIK/NF-kappaB signaling (GO:0038061)3.35177164
54detection of biotic stimulus (GO:0009595)3.34678460
55Arp2/3 complex-mediated actin nucleation (GO:0034314)3.33873786
56germinal center formation (GO:0002467)3.29996784
57response to protozoan (GO:0001562)3.28426550
58positive regulation of antigen processing and presentation (GO:0002579)3.27856165
59T cell homeostasis (GO:0043029)3.26350472
60positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.26238685
61leukocyte aggregation (GO:0070486)3.24967352
62interferon-gamma-mediated signaling pathway (GO:0060333)3.24916911
63lymphocyte homeostasis (GO:0002260)3.24719600
64neutrophil mediated immunity (GO:0002446)3.24698864
65respiratory burst (GO:0045730)3.24170203
66myeloid cell activation involved in immune response (GO:0002275)3.22028942
67regulation of interferon-alpha production (GO:0032647)3.21409091
68negative thymic T cell selection (GO:0045060)3.20702333
69negative regulation of B cell proliferation (GO:0030889)3.19696164
70regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.16568199
71angiogenesis involved in wound healing (GO:0060055)3.16307274
72regulation of mast cell activation (GO:0033003)3.13866019
73negative T cell selection (GO:0043383)3.12882448
74interferon-gamma production (GO:0032609)3.12570840
75response to type I interferon (GO:0034340)3.12124950
76type I interferon signaling pathway (GO:0060337)3.10084944
77cellular response to type I interferon (GO:0071357)3.10084944
78response to muramyl dipeptide (GO:0032495)3.09481431
79positive thymic T cell selection (GO:0045059)3.07488233
80positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.07062063
81regulation of T cell receptor signaling pathway (GO:0050856)3.07047326
82response to peptidoglycan (GO:0032494)3.06647929
83myeloid dendritic cell differentiation (GO:0043011)3.03971409
84negative regulation of leukocyte mediated immunity (GO:0002704)3.02733772
85regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.01748043
86macrophage activation involved in immune response (GO:0002281)3.00935399
87mast cell degranulation (GO:0043303)3.00771171
88mast cell activation involved in immune response (GO:0002279)3.00771171
89leukocyte homeostasis (GO:0001776)2.99651846
90regulation of alpha-beta T cell proliferation (GO:0046640)2.99541595
91response to host (GO:0075136)2.99372536
92response to host defenses (GO:0052200)2.99372536
93response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.99372536
94production of molecular mediator involved in inflammatory response (GO:0002532)2.99014424
95positive regulation of mast cell activation (GO:0033005)2.97391820
96negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.97170563
97regulation of tolerance induction (GO:0002643)2.96401347
98positive regulation of interleukin-1 beta secretion (GO:0050718)2.96105791
99negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.91604399
100dendritic cell migration (GO:0036336)2.90600985
101definitive hemopoiesis (GO:0060216)2.90571867
102dendritic cell chemotaxis (GO:0002407)2.90102094
103myeloid leukocyte activation (GO:0002274)2.88951635
104regulation of mast cell degranulation (GO:0043304)2.88582399
105T-helper 1 type immune response (GO:0042088)2.87900761
106negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.87827273
107tolerance induction (GO:0002507)2.86584248
108regulation of T cell tolerance induction (GO:0002664)2.85491962
109positive regulation of interleukin-2 production (GO:0032743)2.85325214
110negative regulation of adaptive immune response (GO:0002820)2.84435170
111megakaryocyte development (GO:0035855)2.83587075
112B cell mediated immunity (GO:0019724)2.83500058
113regulation of interleukin-1 beta secretion (GO:0050706)2.83411822
114regulation of antigen processing and presentation (GO:0002577)2.82872550
115positive regulation of interferon-beta production (GO:0032728)2.81949785
116positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.81265790
117histamine secretion (GO:0001821)2.81228183
118cellular response to interferon-beta (GO:0035458)2.81196624
119regulation of interleukin-8 biosynthetic process (GO:0045414)2.80668239
120positive regulation of interleukin-12 production (GO:0032735)2.78676951
121regulation of B cell proliferation (GO:0030888)2.78601994
122antigen processing and presentation via MHC class Ib (GO:0002475)2.78415304
123leukocyte degranulation (GO:0043299)2.78306076
124regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.78151316
125regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.77854994
126lymphoid progenitor cell differentiation (GO:0002320)2.77827055
127positive regulation of toll-like receptor signaling pathway (GO:0034123)2.76693135
128antigen receptor-mediated signaling pathway (GO:0050851)2.76461343
129positive T cell selection (GO:0043368)2.76039947
130negative regulation of immunoglobulin mediated immune response (GO:0002890)2.75464719
131negative regulation of B cell mediated immunity (GO:0002713)2.75464719
132regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.75234854
133dendritic cell differentiation (GO:0097028)2.75194550
134positive regulation of alpha-beta T cell proliferation (GO:0046641)2.74631772
135mature B cell differentiation involved in immune response (GO:0002313)2.72680012
136response to interleukin-15 (GO:0070672)2.72021166
137T cell selection (GO:0045058)2.71308625
138hepatocyte apoptotic process (GO:0097284)2.71259456
139response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.69102441
140response to host immune response (GO:0052572)2.69102441
141regulation of mast cell activation involved in immune response (GO:0033006)2.68792677

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.06311188
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.02209070
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.78867093
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.48095914
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.43343671
6BP1_19119308_ChIP-ChIP_Hs578T_Human4.25547805
7* MECOM_23826213_ChIP-Seq_KASUMI_Mouse4.02280957
8SCL_19346495_ChIP-Seq_HPC-7_Human3.64398928
9* IRF8_27001747_Chip-Seq_BMDM_Mouse3.60769234
10* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.49658937
11SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.45798090
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.30443455
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.09730995
14E2F7_22180533_ChIP-Seq_HELA_Human2.98487498
15* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.90963319
16* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.89768577
17RUNX_20019798_ChIP-Seq_JUKART_Human2.85957114
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.79628984
19FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.61631725
20* SPI1_23547873_ChIP-Seq_NB4_Human2.48060905
21* MYB_26560356_Chip-Seq_TH2_Human2.47395168
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.33901133
23SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.26170766
24VDR_21846776_ChIP-Seq_THP-1_Human2.10443773
25* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.08789518
26* MYB_26560356_Chip-Seq_TH1_Human2.07848121
27Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.04479245
28VDR_24763502_ChIP-Seq_THP-1_Human2.00440583
29* MAF_26560356_Chip-Seq_TH1_Human1.94704636
30ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.92970350
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.91962457
32RUNX1_22412390_ChIP-Seq_EML_Mouse1.91805626
33FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.88158445
34* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.87816557
35EGR1_19374776_ChIP-ChIP_THP-1_Human1.84078078
36VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.82228468
37GATA1_22025678_ChIP-Seq_K562_Human1.75870269
38LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.75718573
39SPI1_23127762_ChIP-Seq_K562_Human1.74537025
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.74202904
41ZNF274_21170338_ChIP-Seq_K562_Hela1.72970918
42* PU_27001747_Chip-Seq_BMDM_Mouse1.72187758
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.71553728
44MYC_22102868_ChIP-Seq_BL_Human1.65408033
45LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.61740259
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.59212732
47TAF15_26573619_Chip-Seq_HEK293_Human1.57089624
48ER_23166858_ChIP-Seq_MCF-7_Human1.57048632
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55320235
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.55061621
51CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.54289079
52RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.53303500
53* UTX_26944678_Chip-Seq_JUKART_Human1.52918247
54VDR_24787735_ChIP-Seq_THP-1_Human1.51422857
55GATA3_27048872_Chip-Seq_THYMUS_Human1.48211673
56* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.44112379
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.41591469
58NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.41378223
59* P300_19829295_ChIP-Seq_ESCs_Human1.41166428
60* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.41100926
61GATA2_21666600_ChIP-Seq_HMVEC_Human1.40972787
62E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.40570186
63GBX2_23144817_ChIP-Seq_PC3_Human1.37215119
64HOXB4_20404135_ChIP-ChIP_EML_Mouse1.33805742
65PRDM14_20953172_ChIP-Seq_ESCs_Human1.33164849
66TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.32680016
67NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.31901992
68VDR_22108803_ChIP-Seq_LS180_Human1.31037822
69* GATA3_26560356_Chip-Seq_TH2_Human1.29271240
70SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.27727586
71GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.27092622
72PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25273821
73FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.23987885
74* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.23594174
75TCF7_22412390_ChIP-Seq_EML_Mouse1.23529996
76* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23117349
77* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.20008334
78ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17787257
79* SMRT_27268052_Chip-Seq_Bcells_Human1.16220714
80NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.15631735
81CDX2_19796622_ChIP-Seq_MESCs_Mouse1.15097613
82* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14505584
83* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.13681459
84SALL1_21062744_ChIP-ChIP_HESCs_Human1.13062958
85BCAT_22108803_ChIP-Seq_LS180_Human1.12506803
86* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11860696
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11689059
88GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.11273550
89FLI1_21867929_ChIP-Seq_TH2_Mouse1.10926228
90AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09600450
91CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06390027
92* SMAD3_21741376_ChIP-Seq_EPCs_Human1.06386460
93TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05323025
94MAF_26560356_Chip-Seq_TH2_Human1.04262011
95BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.03753042
96FLI1_27457419_Chip-Seq_LIVER_Mouse1.03025240
97* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02757497
98* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.02459417
99* SMAD3_21741376_ChIP-Seq_HESCs_Human1.02152934
100PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.00953334
101* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00729521
102POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00608965
103TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00608965
104SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.00579334
105CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00501084
106IRF1_19129219_ChIP-ChIP_H3396_Human0.99716153
107STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.99392837
108* CRX_20693478_ChIP-Seq_RETINA_Mouse0.98111662
109* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96973081
110IGF1R_20145208_ChIP-Seq_DFB_Human0.96478979
111* MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.96418694
112EWS_26573619_Chip-Seq_HEK293_Human0.95976991
113* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.95310551
114TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94590789
115* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94169896
116* SALL4_22934838_ChIP-ChIP_CD34+_Human0.92205494
117EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.91814796
118* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91204422
119* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91166796
120MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91000435
121CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.90507981
122* NANOG_18555785_Chip-Seq_ESCs_Mouse0.90152814
123KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.89188617
124* GATA1_19941827_ChIP-Seq_MEL_Mouse0.88916683
125* GATA3_26560356_Chip-Seq_TH1_Human0.88605139
126CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87856830
127HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.87422793
128TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.87120366
129CBP_20019798_ChIP-Seq_JUKART_Human0.86970922
130ELK1_19687146_ChIP-ChIP_HELA_Human0.83271884
131* PCGF2_27294783_Chip-Seq_ESCs_Mouse0.82464615
132TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.82390555
133CIITA_25753668_ChIP-Seq_RAJI_Human0.79283704
134RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78677486
135CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.77323434
136IKZF1_21737484_ChIP-ChIP_HCT116_Human0.76686690
137* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.75570872
138CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75548605
139SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.75300802
140STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.73314806
141GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72207813
142FOXM1_23109430_ChIP-Seq_U2OS_Human0.71241132
143KDM2B_26808549_Chip-Seq_SUP-B15_Human0.70181011
144ETS1_22383799_ChIP-Seq_G1ME_Mouse0.69797381
145FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.67793050
146PU.1_20513432_ChIP-Seq_Bcells_Mouse0.67120891
147KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.65086053
148* NFE2_27457419_Chip-Seq_LIVER_Mouse0.64486347
149* EZH2_27294783_Chip-Seq_NPCs_Mouse0.64418083

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.85185799
2MP0005671_abnormal_response_to3.29111914
3MP0001800_abnormal_humoral_immune3.25244538
4MP0009785_altered_susceptibility_to3.09317256
5MP0000685_abnormal_immune_system3.07287802
6MP0002452_abnormal_antigen_presenting2.99604126
7MP0005387_immune_system_phenotype2.97526593
8MP0001790_abnormal_immune_system2.97526593
9MP0002396_abnormal_hematopoietic_system2.94658147
10MP0005000_abnormal_immune_tolerance2.92447008
11MP0002148_abnormal_hypersensitivity_rea2.90801944
12MP0002723_abnormal_immune_serum2.77238478
13MP0002420_abnormal_adaptive_immunity2.76391247
14MP0001819_abnormal_immune_cell2.75455198
15MP0002419_abnormal_innate_immunity2.74220309
16MP0002166_altered_tumor_susceptibility2.69165682
17MP0005025_abnormal_response_to2.68931212
18MP0003436_decreased_susceptibility_to2.61817237
19MP0002398_abnormal_bone_marrow2.41069515
20MP0005174_abnormal_tail_pigmentation2.30320521
21MP0002006_tumorigenesis2.27895183
22MP0003763_abnormal_thymus_physiology2.27264164
23MP0000569_abnormal_digit_pigmentation2.26402900
24MP0003303_peritoneal_inflammation2.25284769
25MP0000716_abnormal_immune_system2.23942518
26MP0003724_increased_susceptibility_to2.14368499
27MP0000015_abnormal_ear_pigmentation2.06806587
28MP0003195_calcinosis1.99591989
29MP0005464_abnormal_platelet_physiology1.98045906
30MP0000689_abnormal_spleen_morphology1.96482452
31MP0002405_respiratory_system_inflammati1.94159248
32MP0001873_stomach_inflammation1.92475639
33MP0004808_abnormal_hematopoietic_stem1.89481268
34MP0002429_abnormal_blood_cell1.84961021
35MP0002722_abnormal_immune_system1.84238474
36MP0001853_heart_inflammation1.78584827
37MP0000465_gastrointestinal_hemorrhage1.73623792
38MP0010155_abnormal_intestine_physiology1.72006718
39MP0005397_hematopoietic_system_phenotyp1.70594491
40MP0001545_abnormal_hematopoietic_system1.70594491
41MP0008057_abnormal_DNA_replication1.67869789
42MP0001845_abnormal_inflammatory_respons1.65142561
43MP0008004_abnormal_stomach_pH1.60194624
44MP0000703_abnormal_thymus_morphology1.58859823
45MP0009333_abnormal_splenocyte_physiolog1.55576201
46MP0003890_abnormal_embryonic-extraembry1.52143770
47MP0004510_myositis1.47267980
48MP0003221_abnormal_cardiomyocyte_apopto1.45021008
49MP0009278_abnormal_bone_marrow1.42813779
50MP0005075_abnormal_melanosome_morpholog1.42240749
51MP0004883_abnormal_blood_vessel1.41975311
52MP0002132_abnormal_respiratory_system1.40807433
53MP0002095_abnormal_skin_pigmentation1.40141896
54MP0003183_abnormal_peptide_metabolism1.39479685
55MP0008260_abnormal_autophagy1.36154034
56MP0003300_gastrointestinal_ulcer1.35603375
57MP0001879_abnormal_lymphatic_vessel1.34173542
58MP0003866_abnormal_defecation1.30855399
59MP0003191_abnormal_cellular_cholesterol1.29765658
60MP0006082_CNS_inflammation1.28973144
61MP0000490_abnormal_crypts_of1.28591551
62MP0003172_abnormal_lysosome_physiology1.26738858
63MP0005310_abnormal_salivary_gland1.24577854
64MP0002009_preneoplasia1.21290110
65MP0005409_darkened_coat_color1.21090239
66MP0002102_abnormal_ear_morphology1.19502358
67MP0008469_abnormal_protein_level1.14158857
68MP0004947_skin_inflammation1.13709084
69MP0003448_altered_tumor_morphology1.13411126
70MP0001533_abnormal_skeleton_physiology1.09548500
71MP0009764_decreased_sensitivity_to1.07669438
72MP0000604_amyloidosis1.06062821
73MP0000343_altered_response_to1.05561496
74MP0003828_pulmonary_edema1.05051999
75MP0002933_joint_inflammation1.04971035
76MP0004484_altered_response_of1.04081777
77MP0002138_abnormal_hepatobiliary_system1.03778538
78MP0000858_altered_metastatic_potential1.00454262
79MP0005058_abnormal_lysosome_morphology0.97934354
80MP0002277_abnormal_respiratory_mucosa0.93803044
81MP0002998_abnormal_bone_remodeling0.89052574
82MP0003656_abnormal_erythrocyte_physiolo0.87825266
83MP0000371_diluted_coat_color0.86903355
84MP0005084_abnormal_gallbladder_morpholo0.86870291
85MP0008877_abnormal_DNA_methylation0.86532994
86MP0009765_abnormal_xenobiotic_induced0.84659776
87MP0002332_abnormal_exercise_endurance0.84419215
88MP0005164_abnormal_response_to0.84282749
89MP0005167_abnormal_blood-brain_barrier0.81834247
90MP0001851_eye_inflammation0.81495457
91MP0003690_abnormal_glial_cell0.81125687
92MP0002928_abnormal_bile_duct0.81022211
93MP0006054_spinal_hemorrhage0.80445917
94MP0000249_abnormal_blood_vessel0.77444630
95MP0009697_abnormal_copulation0.77391888
96MP0001986_abnormal_taste_sensitivity0.76929813
97MP0002019_abnormal_tumor_incidence0.76614858
98MP0003943_abnormal_hepatobiliary_system0.73256241
99MP0008007_abnormal_cellular_replicative0.70511361
100MP0003787_abnormal_imprinting0.69688605
101MP0002163_abnormal_gland_morphology0.67055972
102MP0004742_abnormal_vestibular_system0.66818774
103MP0004381_abnormal_hair_follicle0.64892415
104MP0008995_early_reproductive_senescence0.64712773
105MP0010307_abnormal_tumor_latency0.64140491
106MP0001188_hyperpigmentation0.63938261
107MP0005166_decreased_susceptibility_to0.62953564
108MP0001348_abnormal_lacrimal_gland0.61307344
109MP0003091_abnormal_cell_migration0.61185694
110MP0009763_increased_sensitivity_to0.60095378
111MP0001663_abnormal_digestive_system0.59663073
112MP0005379_endocrine/exocrine_gland_phen0.59113292
113MP0002075_abnormal_coat/hair_pigmentati0.58906877
114MP0000767_abnormal_smooth_muscle0.57781602
115MP0005645_abnormal_hypothalamus_physiol0.53724013
116MP0003075_altered_response_to0.53062028
117MP0001186_pigmentation_phenotype0.53057068
118MP0003121_genomic_imprinting0.52934511
119MP0000372_irregular_coat_pigmentation0.52442392
120MP0008874_decreased_physiological_sensi0.51506111
121MP0010094_abnormal_chromosome_stability0.50197249
122MP0002254_reproductive_system_inflammat0.49415735
123MP0003880_abnormal_central_pattern0.49138927
124MP0008058_abnormal_DNA_repair0.48306320
125MP0004147_increased_porphyrin_level0.47086190

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.70146969
2Recurrent bacterial skin infections (HP:0005406)5.16438674
3Myositis (HP:0100614)4.53298899
4Eczematoid dermatitis (HP:0000976)4.41282661
5Chronic otitis media (HP:0000389)4.36739576
6Agammaglobulinemia (HP:0004432)4.31371156
7IgM deficiency (HP:0002850)4.22254353
8Recurrent viral infections (HP:0004429)4.14848410
9Elevated erythrocyte sedimentation rate (HP:0003565)4.13918274
10Recurrent fungal infections (HP:0002841)4.06785224
11Meningitis (HP:0001287)3.90705542
12Thrombocytosis (HP:0001894)3.82610360
13Panhypogammaglobulinemia (HP:0003139)3.80728249
14Retrobulbar optic neuritis (HP:0100654)3.78512786
15Optic neuritis (HP:0100653)3.78512786
16Mediastinal lymphadenopathy (HP:0100721)3.76494636
17Spontaneous hematomas (HP:0007420)3.72114409
18Recurrent skin infections (HP:0001581)3.71914543
19Thyroiditis (HP:0100646)3.65263067
20Gastrointestinal infarctions (HP:0005244)3.59095706
21Colitis (HP:0002583)3.58664183
22Abnormal delayed hypersensitivity skin test (HP:0002963)3.54563146
23Chronic obstructive pulmonary disease (HP:0006510)3.54320716
24Obstructive lung disease (HP:0006536)3.54320716
25Chronic mucocutaneous candidiasis (HP:0002728)3.52379301
26Recurrent cutaneous fungal infections (HP:0011370)3.52379301
27Recurrent bronchitis (HP:0002837)3.52159213
28Inflammation of the large intestine (HP:0002037)3.49395823
29Cellulitis (HP:0100658)3.48543549
30Orchitis (HP:0100796)3.43636369
31Vasculitis (HP:0002633)3.41481307
32Gastrointestinal inflammation (HP:0004386)3.31333979
33Abnormality of B cell number (HP:0010975)3.12774635
34B lymphocytopenia (HP:0010976)3.12774635
35Abnormality of macrophages (HP:0004311)3.06465679
36Eosinophilia (HP:0001880)2.87048737
37Recurrent gram-negative bacterial infections (HP:0005420)2.86217608
38Abnormality of T cell physiology (HP:0011840)2.84757051
39Hematochezia (HP:0002573)2.84428681
40Pulmonary infiltrates (HP:0002113)2.82045168
41Abnormality of the prostate (HP:0008775)2.81982096
42Abnormality of T cells (HP:0002843)2.81529631
43IgG deficiency (HP:0004315)2.80477481
44Lymphopenia (HP:0001888)2.80235394
45Gastrointestinal stroma tumor (HP:0100723)2.80107214
46Arterial thrombosis (HP:0004420)2.78432453
47Recurrent pneumonia (HP:0006532)2.75967547
48Encephalitis (HP:0002383)2.73235770
49Abnormality of cells of the lymphoid lineage (HP:0012140)2.67326776
50Recurrent sinusitis (HP:0011108)2.63447033
51Osteomyelitis (HP:0002754)2.63198528
52Prolonged bleeding time (HP:0003010)2.63019346
53Granulocytopenia (HP:0001913)2.59750216
54Urticaria (HP:0001025)2.59670118
55Chronic sinusitis (HP:0011109)2.59630090
56Leukocytosis (HP:0001974)2.58422869
57Abnormality of T cell number (HP:0011839)2.58302042
58Gangrene (HP:0100758)2.57777081
59T lymphocytopenia (HP:0005403)2.57087020
60Papilledema (HP:0001085)2.56656917
61Chronic diarrhea (HP:0002028)2.56156493
62Abnormality of eosinophils (HP:0001879)2.53394145
63Progressive inability to walk (HP:0002505)2.53334846
64Anorexia (HP:0002039)2.53125443
65Gingivitis (HP:0000230)2.48915301
66Keratoconjunctivitis sicca (HP:0001097)2.48767473
67Pulmonary embolism (HP:0002204)2.47888363
68Periodontitis (HP:0000704)2.47743514
69Amyotrophic lateral sclerosis (HP:0007354)2.47472538
70Recurrent lower respiratory tract infections (HP:0002783)2.46715901
71Stomatitis (HP:0010280)2.44898361
72Abnormality of the fingertips (HP:0001211)2.44106790
73Chest pain (HP:0100749)2.43458895
74Hemoptysis (HP:0002105)2.42998926
75Hypochromic microcytic anemia (HP:0004840)2.38529015
76Prostate neoplasm (HP:0100787)2.38338970
77Petechiae (HP:0000967)2.35837004
78Increased IgM level (HP:0003496)2.34498774
79Basal ganglia calcification (HP:0002135)2.33891147
80IgA deficiency (HP:0002720)2.30510311
81Acute myeloid leukemia (HP:0004808)2.30092222
82Absent frontal sinuses (HP:0002688)2.28750173
83Pustule (HP:0200039)2.25475730
84Epistaxis (HP:0000421)2.25292042
85Keratoconjunctivitis (HP:0001096)2.23738751
86Sepsis (HP:0100806)2.23284462
87Dynein arm defect of respiratory motile cilia (HP:0012255)2.21853290
88Absent/shortened dynein arms (HP:0200106)2.21853290
89Stomach cancer (HP:0012126)2.20184667
90Autoimmune hemolytic anemia (HP:0001890)2.18998106
91Episodic fever (HP:0001954)2.18564839
92Hypergammaglobulinemia (HP:0010702)2.18231274
93Severe combined immunodeficiency (HP:0004430)2.18182813
94Abnormality of the pleura (HP:0002103)2.17646348
95Interstitial pulmonary disease (HP:0006530)2.17087414
96Viral hepatitis (HP:0006562)2.11942436
97Nasal polyposis (HP:0100582)2.11827405
98Increased IgE level (HP:0003212)2.10003823
99Verrucae (HP:0200043)2.08312647
100Papilloma (HP:0012740)2.08312647
101Lymphoma (HP:0002665)2.08237333
102Peritonitis (HP:0002586)2.06715714
103Disinhibition (HP:0000734)2.05464845
104Autoimmune thrombocytopenia (HP:0001973)2.03688996
105Neoplasm of the tracheobronchial system (HP:0100552)2.03602371
106Abnormality of the nasal mucosa (HP:0000433)2.03217809
107Hypoplasia of the thymus (HP:0000778)2.01904647
108Vertigo (HP:0002321)2.00049051
109Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.99769737
110Reticulocytopenia (HP:0001896)1.99595716
111Leukopenia (HP:0001882)1.97664992
112Gingival bleeding (HP:0000225)1.96416508
113Syringomyelia (HP:0003396)1.95977414
114Spinal cord lesions (HP:0100561)1.95977414
115Acute lymphatic leukemia (HP:0006721)1.95782550
116Fatigue (HP:0012378)1.93905568
117Vacuolated lymphocytes (HP:0001922)1.93379164
118Keratitis (HP:0000491)1.93178107
119Increased neuronal autofluorescent lipopigment (HP:0002074)1.91974683
120Hypochromic anemia (HP:0001931)1.91914750
121Polyneuropathy (HP:0001271)1.90171721
122Abolished electroretinogram (ERG) (HP:0000550)1.89043246
123Absent rod-and cone-mediated responses on ERG (HP:0007688)1.86842943
124Amaurosis fugax (HP:0100576)1.86464351
125Alveolar cell carcinoma (HP:0006519)1.86153188
126Bronchitis (HP:0012387)1.84247807
127Abnormality of the endocardium (HP:0004306)1.78674005
128Combined immunodeficiency (HP:0005387)1.76948646
129Thrombophlebitis (HP:0004418)1.76397185
130Acute hepatic failure (HP:0006554)1.76159801
131Absent speech (HP:0001344)1.75630345
132Abnormal respiratory epithelium morphology (HP:0012253)1.74770695
133Abnormal respiratory motile cilium morphology (HP:0005938)1.74770695
134Joint swelling (HP:0001386)1.73076780

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.83284412
2MAP3K143.46980602
3KIT3.21309310
4IRAK43.01044187
5TEC2.90935438
6TYK22.70927535
7TXK2.54325687
8BLK2.45970184
9RIPK42.37040689
10CSF1R2.32251590
11BTK2.21769504
12JAK32.18007619
13IKBKE2.10370093
14IKBKB2.10094953
15TBK12.07989688
16SYK1.95874521
17FES1.95246510
18MAP3K131.93869422
19SIK31.77124960
20JAK11.69345024
21TRIM281.69227267
22SIK21.66351443
23FLT31.62274030
24MAP4K21.61353936
25ITK1.53144149
26STK101.50677804
27BCR1.46810485
28HCK1.46634074
29CLK11.45579042
30ZAP701.45143028
31LCK1.44441136
32IRAK31.42147118
33CAMKK21.37336095
34LYN1.35767433
35CSK1.34436153
36TNIK1.33231214
37TIE11.29907716
38NLK1.29501674
39TGFBR21.29286470
40MAP3K41.28167839
41KDR1.27413155
42TAOK31.26392631
43CHUK1.25511469
44GRK61.24824317
45PIM11.22716224
46WNK31.17731411
47FGFR31.15215569
48MARK31.06306222
49CASK1.05499954
50YES11.05353022
51IRAK21.03865863
52MAP3K121.03488508
53MAP2K41.02079667
54MAP2K70.97465191
55TGFBR10.96950971
56ADRBK20.92233271
57STK40.92052883
58PRKCQ0.89173052
59MATK0.87576080
60LRRK20.86118030
61EIF2AK20.77092624
62PIK3CG0.76960560
63MAP3K50.76476583
64FRK0.76081874
65SGK20.74825709
66ADRBK10.74437625
67NUAK10.73960722
68PIM20.73492799
69TAOK10.72468631
70MAP3K60.67199820
71EIF2AK30.66595364
72BMPR20.63084679
73TRPM70.61979216
74ERBB40.61072327
75KSR10.59959566
76MAP2K30.59112897
77DAPK20.58612318
78GRK10.58462775
79OXSR10.57998628
80STK160.57672003
81MAPK40.56592047
82JAK20.54890729
83HIPK20.54093422
84PKN10.53800248
85BMPR1B0.53560248
86PTK2B0.52992446
87PLK20.52216670
88FGR0.51431954
89VRK10.50771917
90BRD40.50546059
91ACVR1B0.50274635
92IRAK10.49235705
93TNK20.48181228
94ABL10.47884099
95EPHB10.47421716
96MAPK120.47049828
97EPHA30.46870789
98MARK10.46451285
99PAK30.46430714
100PDK10.45904338
101MST40.45824139
102MAPK130.45467893
103CAMK1D0.44644059
104STK240.44174589
105RIPK10.42976246
106PRKAA20.42851322
107ATR0.42501160
108PRKCD0.42133240
109PINK10.41853028
110GRK70.41155502
111FYN0.40622307
112RPS6KA40.40152399
113TLK10.39681810
114STK110.39493187
115MAP3K20.38983128
116MAP3K10.38378866
117CSNK1G20.38131928
118ZAK0.38007254
119MAP3K110.37011859
120NME20.36780356
121ERBB30.35410145
122RAF10.35310652
123DYRK1A0.34994279
124CAMK40.34768602
125CDK120.34554917
126DYRK1B0.34176806
127RPS6KA60.33897961
128EEF2K0.33705745
129DYRK30.32923170
130EGFR0.32722081
131RPS6KA50.32473028
132MAP3K100.31212031
133CDK60.29775410
134FGFR40.29524676
135MKNK20.29521873
136MAP2K60.29321944
137CDK190.28122575

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.21735400
2B cell receptor signaling pathway_Homo sapiens_hsa046622.61617952
3Intestinal immune network for IgA production_Homo sapiens_hsa046722.58447369
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.55253360
5Leishmaniasis_Homo sapiens_hsa051402.52581031
6Measles_Homo sapiens_hsa051622.23749223
7Osteoclast differentiation_Homo sapiens_hsa043802.17906028
8Toll-like receptor signaling pathway_Homo sapiens_hsa046202.15234085
9Allograft rejection_Homo sapiens_hsa053302.11783594
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.03371522
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.03122024
12RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.99907620
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.92350591
14Hematopoietic cell lineage_Homo sapiens_hsa046401.86160499
15NOD-like receptor signaling pathway_Homo sapiens_hsa046211.80932412
16Graft-versus-host disease_Homo sapiens_hsa053321.80440447
17Antigen processing and presentation_Homo sapiens_hsa046121.76362918
18Herpes simplex infection_Homo sapiens_hsa051681.60455643
19T cell receptor signaling pathway_Homo sapiens_hsa046601.57503512
20Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.53769488
21Jak-STAT signaling pathway_Homo sapiens_hsa046301.52829062
22Chemokine signaling pathway_Homo sapiens_hsa040621.52760253
23Tuberculosis_Homo sapiens_hsa051521.52430706
24Toxoplasmosis_Homo sapiens_hsa051451.52261076
25Pertussis_Homo sapiens_hsa051331.51828065
26Influenza A_Homo sapiens_hsa051641.43486233
27TNF signaling pathway_Homo sapiens_hsa046681.34041304
28Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.33539956
29Transcriptional misregulation in cancer_Homo sapiens_hsa052021.33217930
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.33002402
31Viral myocarditis_Homo sapiens_hsa054161.29613810
32Malaria_Homo sapiens_hsa051441.27832565
33Legionellosis_Homo sapiens_hsa051341.26966896
34Apoptosis_Homo sapiens_hsa042101.24178106
35Shigellosis_Homo sapiens_hsa051311.23700687
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.23118892
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.22630402
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.22497735
39Autoimmune thyroid disease_Homo sapiens_hsa053201.20697703
40Hepatitis B_Homo sapiens_hsa051611.20380020
41Leukocyte transendothelial migration_Homo sapiens_hsa046701.18699255
42Non-homologous end-joining_Homo sapiens_hsa034501.16843770
43Acute myeloid leukemia_Homo sapiens_hsa052211.15866107
44Salmonella infection_Homo sapiens_hsa051321.06215021
45African trypanosomiasis_Homo sapiens_hsa051431.05284027
46Platelet activation_Homo sapiens_hsa046111.01903042
47Rheumatoid arthritis_Homo sapiens_hsa053231.01687299
48Type I diabetes mellitus_Homo sapiens_hsa049401.01602597
49Staphylococcus aureus infection_Homo sapiens_hsa051501.00972816
50Asthma_Homo sapiens_hsa053100.94388100
51Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.92482372
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91068431
53DNA replication_Homo sapiens_hsa030300.88847410
54Epstein-Barr virus infection_Homo sapiens_hsa051690.87974644
55Other glycan degradation_Homo sapiens_hsa005110.86175635
56Hepatitis C_Homo sapiens_hsa051600.85593247
57Pancreatic cancer_Homo sapiens_hsa052120.85223212
58Dorso-ventral axis formation_Homo sapiens_hsa043200.85053928
59Chronic myeloid leukemia_Homo sapiens_hsa052200.84737975
60Systemic lupus erythematosus_Homo sapiens_hsa053220.84070035
61Glycosaminoglycan degradation_Homo sapiens_hsa005310.83624488
62AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79467135
63Ribosome_Homo sapiens_hsa030100.78742475
64Phagosome_Homo sapiens_hsa041450.78397228
65Base excision repair_Homo sapiens_hsa034100.76024499
66Viral carcinogenesis_Homo sapiens_hsa052030.74788586
67Fanconi anemia pathway_Homo sapiens_hsa034600.73921279
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72258652
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70562819
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.70363151
71Collecting duct acid secretion_Homo sapiens_hsa049660.69751664
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69331667
73Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68433333
74Small cell lung cancer_Homo sapiens_hsa052220.68108226
75Regulation of autophagy_Homo sapiens_hsa041400.66655890
76Homologous recombination_Homo sapiens_hsa034400.66262958
77HTLV-I infection_Homo sapiens_hsa051660.64411537
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63731398
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62456387
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61585398
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61481599
82Lysosome_Homo sapiens_hsa041420.59955945
83Colorectal cancer_Homo sapiens_hsa052100.58600256
84Morphine addiction_Homo sapiens_hsa050320.54501998
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.53341306
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53187305
87Non-small cell lung cancer_Homo sapiens_hsa052230.52391025
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51108885
89Prolactin signaling pathway_Homo sapiens_hsa049170.50598094
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48846094
91HIF-1 signaling pathway_Homo sapiens_hsa040660.48297548
92Type II diabetes mellitus_Homo sapiens_hsa049300.48181276
93Mismatch repair_Homo sapiens_hsa034300.47827015
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46617208
95Nicotine addiction_Homo sapiens_hsa050330.46011311
96Ether lipid metabolism_Homo sapiens_hsa005650.45994964
97Notch signaling pathway_Homo sapiens_hsa043300.45959959
98MicroRNAs in cancer_Homo sapiens_hsa052060.44791618
99Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44492116
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43930221
101MAPK signaling pathway_Homo sapiens_hsa040100.43733862
102p53 signaling pathway_Homo sapiens_hsa041150.43100248
103Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41232550
104Inositol phosphate metabolism_Homo sapiens_hsa005620.41208010
105Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.40769465
106Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38864398
107Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37872249
108VEGF signaling pathway_Homo sapiens_hsa043700.37593391
109FoxO signaling pathway_Homo sapiens_hsa040680.37165423
110Olfactory transduction_Homo sapiens_hsa047400.35005532
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34466348
112Ras signaling pathway_Homo sapiens_hsa040140.34330874
113Pathways in cancer_Homo sapiens_hsa052000.33791797
114Prostate cancer_Homo sapiens_hsa052150.33205781
115Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32957733
116Renal cell carcinoma_Homo sapiens_hsa052110.32588336
117Alcoholism_Homo sapiens_hsa050340.31986059
118Endocytosis_Homo sapiens_hsa041440.30724691
119RNA degradation_Homo sapiens_hsa030180.30532639
120Taste transduction_Homo sapiens_hsa047420.29689472
121GABAergic synapse_Homo sapiens_hsa047270.26525455
122Phototransduction_Homo sapiens_hsa047440.25199546
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.24076395
124Rap1 signaling pathway_Homo sapiens_hsa040150.24038624
125cAMP signaling pathway_Homo sapiens_hsa040240.23575902

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