ST7L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene was identified by its similarity to the ST7 tumor suppressor gene found in the chromosome 7q31 region. This gene is clustered in a tail-to-tail manner with the WNT2B gene in a chromosomal region known to be deleted and rearranged in a variety of cancers. Several transcript variants encoding many different isoforms have been described, but some have not been fully characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)5.25122273
2central nervous system myelination (GO:0022010)5.25122273
3behavioral response to nicotine (GO:0035095)4.38523471
4nucleotide transmembrane transport (GO:1901679)4.02779146
5regulation of cilium movement (GO:0003352)4.01992156
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.86326826
7protein polyglutamylation (GO:0018095)3.79497231
8preassembly of GPI anchor in ER membrane (GO:0016254)3.76122238
9regulation of mitotic spindle checkpoint (GO:1903504)3.59703680
10regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.59703680
11replication fork processing (GO:0031297)3.58518327
12presynaptic membrane assembly (GO:0097105)3.55788565
13L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.54435698
14GPI anchor biosynthetic process (GO:0006506)3.52222705
15epithelial cilium movement (GO:0003351)3.50228782
16GPI anchor metabolic process (GO:0006505)3.40867896
17centriole replication (GO:0007099)3.37907477
18ganglioside metabolic process (GO:0001573)3.37538274
19mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.36714952
20mitochondrial respiratory chain complex I assembly (GO:0032981)3.36714952
21NADH dehydrogenase complex assembly (GO:0010257)3.36714952
22piRNA metabolic process (GO:0034587)3.36592699
23regulation of somitogenesis (GO:0014807)3.35234191
24response to pheromone (GO:0019236)3.34065909
25behavioral response to ethanol (GO:0048149)3.31470074
26presynaptic membrane organization (GO:0097090)3.31399269
27indole-containing compound catabolic process (GO:0042436)3.30766561
28indolalkylamine catabolic process (GO:0046218)3.30766561
29tryptophan catabolic process (GO:0006569)3.30766561
30eye photoreceptor cell differentiation (GO:0001754)3.30063341
31photoreceptor cell differentiation (GO:0046530)3.30063341
32cellular ketone body metabolic process (GO:0046950)3.26977530
33platelet dense granule organization (GO:0060155)3.25897070
34limb bud formation (GO:0060174)3.25233191
35DNA double-strand break processing (GO:0000729)3.24153417
36meiotic chromosome segregation (GO:0045132)3.19768252
37DNA deamination (GO:0045006)3.17528309
38regulation of centriole replication (GO:0046599)3.17034746
39fatty acid elongation (GO:0030497)3.16657323
40kynurenine metabolic process (GO:0070189)3.14544806
41mannosylation (GO:0097502)3.14319909
42respiratory chain complex IV assembly (GO:0008535)3.11705582
43negative regulation of execution phase of apoptosis (GO:1900118)3.11286193
44regulation of pigment cell differentiation (GO:0050932)3.10692964
45mitochondrial respiratory chain complex assembly (GO:0033108)3.10371118
46lymphoid progenitor cell differentiation (GO:0002320)3.10322700
47long-chain fatty acid biosynthetic process (GO:0042759)3.10196651
48indolalkylamine metabolic process (GO:0006586)3.09698193
49glycolipid biosynthetic process (GO:0009247)3.03421756
50reciprocal DNA recombination (GO:0035825)3.03141987
51reciprocal meiotic recombination (GO:0007131)3.03141987
52oligodendrocyte differentiation (GO:0048709)3.02149444
53DNA methylation involved in gamete generation (GO:0043046)3.00306830
54developmental pigmentation (GO:0048066)2.99994536
55protein neddylation (GO:0045116)2.99437345
56cilium movement (GO:0003341)2.98395888
57recombinational repair (GO:0000725)2.97268331
58energy homeostasis (GO:0097009)2.96525230
59regulation of meiosis I (GO:0060631)2.95518308
60cilium morphogenesis (GO:0060271)2.95184262
61rRNA catabolic process (GO:0016075)2.95172797
62myoblast migration (GO:0051451)2.94717467
63amino acid salvage (GO:0043102)2.94204749
64L-methionine salvage (GO:0071267)2.94204749
65L-methionine biosynthetic process (GO:0071265)2.94204749
66ketone body metabolic process (GO:1902224)2.94020483
67glycosphingolipid biosynthetic process (GO:0006688)2.93808985
68double-strand break repair via homologous recombination (GO:0000724)2.92636092
69cerebral cortex radially oriented cell migration (GO:0021799)2.92393042
70pyrimidine nucleobase catabolic process (GO:0006208)2.91921687
71neural tube formation (GO:0001841)2.91301168
72dendritic cell chemotaxis (GO:0002407)2.90366693
73pseudouridine synthesis (GO:0001522)2.88232903
74sperm motility (GO:0030317)2.88175066
75left/right axis specification (GO:0070986)2.87621238
76cilium organization (GO:0044782)2.86100937
77rRNA methylation (GO:0031167)2.86006225
78fucose catabolic process (GO:0019317)2.85257510
79L-fucose metabolic process (GO:0042354)2.85257510
80L-fucose catabolic process (GO:0042355)2.85257510
81water-soluble vitamin biosynthetic process (GO:0042364)2.84077109
82import into cell (GO:0098657)2.83811491
83L-amino acid import (GO:0043092)2.81834524
84C-terminal protein lipidation (GO:0006501)2.81074471
85tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.80645710
86RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.80645710
87tryptophan metabolic process (GO:0006568)2.78523905
88cilium assembly (GO:0042384)2.78384648
89resolution of meiotic recombination intermediates (GO:0000712)2.78242460
90regulation of activation of Janus kinase activity (GO:0010533)2.77760005
91cyclic nucleotide catabolic process (GO:0009214)2.76110669
92ubiquinone metabolic process (GO:0006743)2.75821451
93ubiquinone biosynthetic process (GO:0006744)2.75462960
94regulation of hexokinase activity (GO:1903299)2.74843810
95regulation of glucokinase activity (GO:0033131)2.74843810
96regulation of timing of cell differentiation (GO:0048505)2.74475490
97intraciliary transport (GO:0042073)2.73962607
98microtubule depolymerization (GO:0007019)2.73345733
99regulation of collateral sprouting (GO:0048670)2.73344959
100rRNA modification (GO:0000154)2.72795243
101axoneme assembly (GO:0035082)2.72584187
102G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.71693831
103regulation of microtubule-based movement (GO:0060632)2.69828574
104negative regulation of telomere maintenance (GO:0032205)2.69674231
105detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.68626060
106methionine biosynthetic process (GO:0009086)2.68298368
107amine catabolic process (GO:0009310)2.67303329
108cellular biogenic amine catabolic process (GO:0042402)2.67303329
109establishment of protein localization to mitochondrial membrane (GO:0090151)2.67094088
110cytochrome complex assembly (GO:0017004)2.66565254
111positive regulation of oligodendrocyte differentiation (GO:0048714)2.65922148
112signal peptide processing (GO:0006465)2.64997425
113male meiosis I (GO:0007141)2.64494506
114positive regulation of cellular amide metabolic process (GO:0034250)2.64377169
115C-terminal protein amino acid modification (GO:0018410)2.63992611
116myelination (GO:0042552)2.63864006
117nucleotide transport (GO:0006862)2.63217349
118ceramide biosynthetic process (GO:0046513)2.62122779
119daunorubicin metabolic process (GO:0044597)2.61438902
120polyketide metabolic process (GO:0030638)2.61438902
121doxorubicin metabolic process (GO:0044598)2.61438902
122protein prenylation (GO:0018342)2.60132774
123prenylation (GO:0097354)2.60132774
124regulation of hippo signaling (GO:0035330)2.59352627
125somite development (GO:0061053)2.58909554
126DNA-dependent DNA replication (GO:0006261)2.58812097
127chaperone-mediated protein transport (GO:0072321)2.58528480
128cell wall macromolecule catabolic process (GO:0016998)2.58499418
129synapsis (GO:0007129)2.58277231
130nucleobase catabolic process (GO:0046113)2.57987102
131neuronal action potential (GO:0019228)2.57478872
132RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.57470749
133superoxide anion generation (GO:0042554)2.56685057
134histone H2B ubiquitination (GO:0033523)2.55749671
135cornea development in camera-type eye (GO:0061303)2.53951284
136male meiosis (GO:0007140)2.52995178
137ensheathment of neurons (GO:0007272)2.52588421
138axon ensheathment (GO:0008366)2.52588421
139positive regulation of steroid hormone secretion (GO:2000833)2.51673009
140nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.51200195
141negative regulation of myoblast differentiation (GO:0045662)2.51091422
142cilium or flagellum-dependent cell motility (GO:0001539)2.50876877
143tRNA processing (GO:0008033)2.49180330
144androgen biosynthetic process (GO:0006702)2.48685173
145positive regulation of interleukin-1 beta secretion (GO:0050718)2.47832387
146retina layer formation (GO:0010842)2.47363269
147response to lipoprotein particle (GO:0055094)2.46822611
148establishment of protein localization to Golgi (GO:0072600)2.45904844
149purinergic nucleotide receptor signaling pathway (GO:0035590)2.45784304
150organelle membrane fusion (GO:0090174)2.45329040
151response to redox state (GO:0051775)2.45019267
152mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.44065949
153mesenchymal cell differentiation involved in kidney development (GO:0072161)2.41974117
154mesenchymal cell differentiation involved in renal system development (GO:2001012)2.41974117
155oligosaccharide catabolic process (GO:0009313)2.41395954
156positive regulation of protein homodimerization activity (GO:0090073)2.41061111
157dendritic cell migration (GO:0036336)2.40963991
158nonmotile primary cilium assembly (GO:0035058)2.40590057
159microglial cell activation (GO:0001774)2.38830697
160neuron remodeling (GO:0016322)2.37128649
161polyol transport (GO:0015791)2.36063692
162autophagic vacuole fusion (GO:0000046)2.35775786
163photoreceptor cell maintenance (GO:0045494)2.34579590
164sialylation (GO:0097503)2.34211446
165detection of other organism (GO:0098543)2.32350536
166positive regulation of smooth muscle cell migration (GO:0014911)2.30258017
167positive regulation of cellular amine metabolic process (GO:0033240)2.30046297
168neutrophil activation involved in immune response (GO:0002283)2.29257681
169negative regulation of neurotransmitter secretion (GO:0046929)2.29014649
170negative regulation of acute inflammatory response (GO:0002674)2.27468636
171postsynaptic membrane organization (GO:0001941)2.24797131
172adenosine metabolic process (GO:0046085)2.24085619
173neuron cell-cell adhesion (GO:0007158)2.23961717
174positive regulation of interleukin-1 secretion (GO:0050716)2.23640459
175cAMP catabolic process (GO:0006198)2.22844268
176ceramide catabolic process (GO:0046514)2.21642599
177intracellular pH reduction (GO:0051452)2.21305963
178positive regulation of toll-like receptor signaling pathway (GO:0034123)2.20121740
179fucosylation (GO:0036065)2.20012963
180protein complex biogenesis (GO:0070271)2.19814789
181membrane lipid biosynthetic process (GO:0046467)2.18904184
182regulation of platelet aggregation (GO:0090330)2.18171064
183negative regulation of transcription by competitive promoter binding (GO:0010944)2.17785171
184startle response (GO:0001964)2.17724425
185regulation of interleukin-1 beta secretion (GO:0050706)2.17204455
186detection of light stimulus involved in visual perception (GO:0050908)2.15144439
187detection of light stimulus involved in sensory perception (GO:0050962)2.15144439
188dentate gyrus development (GO:0021542)2.14011266
189positive regulation of response to oxidative stress (GO:1902884)2.13215833
190positive regulation of cellular response to oxidative stress (GO:1900409)2.13215833
191androgen metabolic process (GO:0008209)2.13140461
192negative regulation of keratinocyte proliferation (GO:0010839)2.11956350
193regulation of development, heterochronic (GO:0040034)2.10698595
194negative regulation of osteoblast proliferation (GO:0033689)2.10632065

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.57615752
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.36469084
3ZNF274_21170338_ChIP-Seq_K562_Hela3.27311192
4* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.76572966
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.52472657
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.44230692
7TAF15_26573619_Chip-Seq_HEK293_Human2.44159042
8PCGF2_27294783_Chip-Seq_ESCs_Mouse2.41305422
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.35439442
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.33791548
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.30908333
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.24451097
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.20800107
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.19149564
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.18931977
16SUZ12_27294783_Chip-Seq_NPCs_Mouse2.10035667
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.08785644
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.08735315
19SMAD_19615063_ChIP-ChIP_OVARY_Human2.06282951
20PCGF2_27294783_Chip-Seq_NPCs_Mouse2.02964668
21AR_21572438_ChIP-Seq_LNCaP_Human2.01318718
22ELK1_19687146_ChIP-ChIP_HELA_Human1.98859517
23NFE2_27457419_Chip-Seq_LIVER_Mouse1.91411366
24* P300_19829295_ChIP-Seq_ESCs_Human1.90703224
25* EST1_17652178_ChIP-ChIP_JURKAT_Human1.90034618
26EZH2_27294783_Chip-Seq_NPCs_Mouse1.87325522
27EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.84247410
28ER_23166858_ChIP-Seq_MCF-7_Human1.83172602
29NANOG_18555785_Chip-Seq_ESCs_Mouse1.80222427
30TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.78590934
31BMI1_23680149_ChIP-Seq_NPCS_Mouse1.78112704
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.76637862
33P53_22387025_ChIP-Seq_ESCs_Mouse1.76062774
34SUZ12_18555785_Chip-Seq_ESCs_Mouse1.74348230
35STAT3_18555785_Chip-Seq_ESCs_Mouse1.67771217
36BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.66934745
37CBX2_27304074_Chip-Seq_ESCs_Mouse1.66142464
38SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.65240262
39P300_18555785_Chip-Seq_ESCs_Mouse1.64734487
40CMYC_18555785_Chip-Seq_ESCs_Mouse1.64652395
41EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.64067937
42IGF1R_20145208_ChIP-Seq_DFB_Human1.63746244
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.63394587
44VDR_22108803_ChIP-Seq_LS180_Human1.63241322
45E2F1_18555785_Chip-Seq_ESCs_Mouse1.62509494
46EED_16625203_ChIP-ChIP_MESCs_Mouse1.62133076
47NOTCH1_21737748_ChIP-Seq_TLL_Human1.59253107
48OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59102474
49NMYC_18555785_Chip-Seq_ESCs_Mouse1.58258644
50FUS_26573619_Chip-Seq_HEK293_Human1.58165561
51RUNX1_27457419_Chip-Seq_LIVER_Mouse1.57725947
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.56295195
53MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.56264344
54MYC_18940864_ChIP-ChIP_HL60_Human1.55340884
55VDR_23849224_ChIP-Seq_CD4+_Human1.54550079
56JARID2_20064375_ChIP-Seq_MESCs_Mouse1.54384866
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52852611
58SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.49154048
59SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.48775317
60SOX2_18555785_Chip-Seq_ESCs_Mouse1.47605292
61CBP_20019798_ChIP-Seq_JUKART_Human1.47245899
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47245899
63EWS_26573619_Chip-Seq_HEK293_Human1.47040632
64OCT4_18555785_Chip-Seq_ESCs_Mouse1.46976394
65GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.46025393
66IRF8_21731497_ChIP-ChIP_J774_Mouse1.45649085
67VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.45273431
68TP53_22573176_ChIP-Seq_HFKS_Human1.44412472
69E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.43883909
70EZH2_27304074_Chip-Seq_ESCs_Mouse1.43758439
71PU1_27457419_Chip-Seq_LIVER_Mouse1.43277333
72EZH2_22144423_ChIP-Seq_EOC_Human1.40763802
73AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40602769
74TAL1_26923725_Chip-Seq_HPCs_Mouse1.40259693
75ZFX_18555785_Chip-Seq_ESCs_Mouse1.39482801
76SMAD4_21799915_ChIP-Seq_A2780_Human1.39455197
77SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.39350330
78SMAD1_18555785_Chip-Seq_ESCs_Mouse1.38847244
79CRX_20693478_ChIP-Seq_RETINA_Mouse1.37866835
80IRF1_19129219_ChIP-ChIP_H3396_Human1.37641979
81SMAD3_21741376_ChIP-Seq_EPCs_Human1.37621095
82CDX2_19796622_ChIP-Seq_MESCs_Mouse1.37322545
83RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37111474
84RUNX_20019798_ChIP-Seq_JUKART_Human1.36913244
85MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.35449252
86CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34296225
87CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.33959285
88E2F4_17652178_ChIP-ChIP_JURKAT_Human1.33620030
89CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33572804
90UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32908506
91KLF4_18555785_Chip-Seq_ESCs_Mouse1.32147598
92RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31679344
93NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.31295856
94NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30486558
95ESRRB_18555785_Chip-Seq_ESCs_Mouse1.30387491
96SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29886010
97CTCF_18555785_Chip-Seq_ESCs_Mouse1.29332194
98POU5F1_16153702_ChIP-ChIP_HESCs_Human1.28539429
99HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.28481505
100RNF2_27304074_Chip-Seq_NSC_Mouse1.27718973
101SOX2_19829295_ChIP-Seq_ESCs_Human1.27402496
102NANOG_19829295_ChIP-Seq_ESCs_Human1.27402496
103PADI4_21655091_ChIP-ChIP_MCF-7_Human1.26517380
104SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.26485523
105TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25431416
106EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.24284472
107WT1_19549856_ChIP-ChIP_CCG9911_Human1.24187154
108TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23148366
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23148366
110IRF8_22096565_ChIP-ChIP_GC-B_Human1.22719740
111SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.21582202
112IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.21382186
113BCAT_22108803_ChIP-Seq_LS180_Human1.20960872
114OCT4_21477851_ChIP-Seq_ESCs_Mouse1.20764815
115PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.20646720
116KDM2B_26808549_Chip-Seq_REH_Human1.20087300
117STAT3_23295773_ChIP-Seq_U87_Human1.19333629
118ETS1_20019798_ChIP-Seq_JURKAT_Human1.18469218
119SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.15289817
120RBPJ_22232070_ChIP-Seq_NCS_Mouse1.14350510
121TP53_18474530_ChIP-ChIP_U2OS_Human1.13900471
122TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12153953
123RUNX2_22187159_ChIP-Seq_PCA_Human1.11952470
124* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.11889390
125KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11355124
126JARID2_20075857_ChIP-Seq_MESCs_Mouse1.11181361
127TCF4_22108803_ChIP-Seq_LS180_Human1.10866711
128FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10791673
129TCF4_23295773_ChIP-Seq_U87_Human1.10412345
130RNF2_27304074_Chip-Seq_ESCs_Mouse1.09913094
131CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08987183
132LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.07868318
133AR_25329375_ChIP-Seq_VCAP_Human1.07803742
134SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.06278978
135FLI1_21867929_ChIP-Seq_TH2_Mouse1.03828165
136* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02718948
137GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02297162
138SRF_21415370_ChIP-Seq_HL-1_Mouse1.02205251
139TP63_19390658_ChIP-ChIP_HaCaT_Human1.01614845
140FOXA1_27270436_Chip-Seq_PROSTATE_Human1.01502029
141FOXA1_25329375_ChIP-Seq_VCAP_Human1.01502029
142AUTS2_25519132_ChIP-Seq_293T-REX_Human1.00264512
143FOXP3_21729870_ChIP-Seq_TREG_Human0.99991619
144AR_20517297_ChIP-Seq_VCAP_Human0.98198862
145SMAD4_21741376_ChIP-Seq_EPCs_Human0.97858563
146NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.97419980
147GATA3_21878914_ChIP-Seq_MCF-7_Human0.97012566

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color3.36764231
2MP0001188_hyperpigmentation3.24982990
3MP0004381_abnormal_hair_follicle3.19781992
4MP0001986_abnormal_taste_sensitivity3.11876566
5MP0005409_darkened_coat_color2.74967568
6MP0005171_absent_coat_pigmentation2.73407857
7MP0003646_muscle_fatigue2.68261976
8MP0008877_abnormal_DNA_methylation2.67884198
9MP0002837_dystrophic_cardiac_calcinosis2.66652764
10MP0006292_abnormal_olfactory_placode2.56208902
11MP0002638_abnormal_pupillary_reflex2.37252939
12MP0005645_abnormal_hypothalamus_physiol2.37234151
13MP0003724_increased_susceptibility_to2.30152155
14MP0005646_abnormal_pituitary_gland2.29850023
15MP0000920_abnormal_myelination2.28999393
16MP0001835_abnormal_antigen_presentation2.13539586
17MP0008058_abnormal_DNA_repair2.08780953
18MP0005075_abnormal_melanosome_morpholog2.08273747
19MP0000566_synostosis2.07463926
20MP0000015_abnormal_ear_pigmentation2.07030066
21MP0002876_abnormal_thyroid_physiology2.02394507
22MP0000372_irregular_coat_pigmentation1.94136904
23MP0002102_abnormal_ear_morphology1.88130248
24MP0005379_endocrine/exocrine_gland_phen1.87507404
25MP0002653_abnormal_ependyma_morphology1.85625099
26MP0006072_abnormal_retinal_apoptosis1.82624472
27MP0003195_calcinosis1.81715021
28MP0005174_abnormal_tail_pigmentation1.78950463
29MP0003787_abnormal_imprinting1.74933966
30MP0009697_abnormal_copulation1.73557392
31MP0003690_abnormal_glial_cell1.73382256
32MP0003880_abnormal_central_pattern1.70531747
33MP0003718_maternal_effect1.69589985
34MP0006082_CNS_inflammation1.67670581
35MP0002234_abnormal_pharynx_morphology1.64520242
36MP0004742_abnormal_vestibular_system1.60702416
37MP0002148_abnormal_hypersensitivity_rea1.59441904
38MP0004133_heterotaxia1.58590098
39MP0002009_preneoplasia1.58333918
40MP0005423_abnormal_somatic_nervous1.55323482
41MP0008260_abnormal_autophagy1.55162831
42MP0003890_abnormal_embryonic-extraembry1.52162778
43MP0005671_abnormal_response_to1.52032741
44MP0005551_abnormal_eye_electrophysiolog1.51805956
45MP0004043_abnormal_pH_regulation1.49992046
46MP0002132_abnormal_respiratory_system1.49312639
47MP0003950_abnormal_plasma_membrane1.49193319
48MP0002160_abnormal_reproductive_system1.48749949
49MP0002277_abnormal_respiratory_mucosa1.44442230
50MP0004145_abnormal_muscle_electrophysio1.43943808
51MP0003786_premature_aging1.40995392
52MP0000427_abnormal_hair_cycle1.40732983
53MP0001293_anophthalmia1.37342583
54MP0002938_white_spotting1.35555768
55MP0003183_abnormal_peptide_metabolism1.34573178
56MP0002419_abnormal_innate_immunity1.33050897
57MP0001800_abnormal_humoral_immune1.33016980
58MP0004215_abnormal_myocardial_fiber1.32111584
59MP0001661_extended_life_span1.31143474
60MP0001346_abnormal_lacrimal_gland1.31035920
61MP0002095_abnormal_skin_pigmentation1.29555229
62MP0004142_abnormal_muscle_tone1.29310875
63MP0001502_abnormal_circadian_rhythm1.29164802
64MP0008995_early_reproductive_senescence1.26990943
65MP0002723_abnormal_immune_serum1.23695055
66MP0000685_abnormal_immune_system1.22641013
67MP0001486_abnormal_startle_reflex1.22503172
68MP0008789_abnormal_olfactory_epithelium1.20662035
69MP0001929_abnormal_gametogenesis1.20349656
70MP0003121_genomic_imprinting1.18563452
71MP0002452_abnormal_antigen_presenting1.18092863
72MP0005387_immune_system_phenotype1.17450451
73MP0001790_abnormal_immune_system1.17450451
74MP0008057_abnormal_DNA_replication1.17329494
75MP0002210_abnormal_sex_determination1.17198676
76MP0002751_abnormal_autonomic_nervous1.16729689
77MP0000647_abnormal_sebaceous_gland1.15758213
78MP0001529_abnormal_vocalization1.15730725
79MP0004147_increased_porphyrin_level1.14581185
80MP0000569_abnormal_digit_pigmentation1.14519409
81MP0003698_abnormal_male_reproductive1.14404286
82MP0000778_abnormal_nervous_system1.13064552
83MP0008872_abnormal_physiological_respon1.11989831
84MP0005670_abnormal_white_adipose1.11964390
85MP0002163_abnormal_gland_morphology1.11816628
86MP0005000_abnormal_immune_tolerance1.10028419
87MP0004134_abnormal_chest_morphology1.09512655
88MP0005187_abnormal_penis_morphology1.08712631
89MP0006035_abnormal_mitochondrial_morpho1.08594896
90MP0003937_abnormal_limbs/digits/tail_de1.07970971
91MP0002928_abnormal_bile_duct1.07713583
92MP0001905_abnormal_dopamine_level1.07140305
93MP0009785_altered_susceptibility_to1.05505083
94MP0003137_abnormal_impulse_conducting1.04070327
95MP0000653_abnormal_sex_gland1.03810292
96MP0010094_abnormal_chromosome_stability1.03730860
97MP0005389_reproductive_system_phenotype1.03457874
98MP0003011_delayed_dark_adaptation1.02628981
99MP0000026_abnormal_inner_ear1.02589311
100MP0003186_abnormal_redox_activity1.00512941
101MP0000383_abnormal_hair_follicle1.00428696
102MP0001819_abnormal_immune_cell0.99314385
103MP0002420_abnormal_adaptive_immunity0.99308860
104MP0005410_abnormal_fertilization0.98730096
105MP0005025_abnormal_response_to0.97624403
106MP0005391_vision/eye_phenotype0.97322594
107MP0001851_eye_inflammation0.96294133
108MP0002233_abnormal_nose_morphology0.96089519
109MP0002272_abnormal_nervous_system0.95885623
110MP0008775_abnormal_heart_ventricle0.95769319
111MP0005253_abnormal_eye_physiology0.95742449
112MP0000631_abnormal_neuroendocrine_gland0.94437963
113MP0000049_abnormal_middle_ear0.92291088
114MP0001145_abnormal_male_reproductive0.92263520
115MP0002282_abnormal_trachea_morphology0.91375947
116MP0001963_abnormal_hearing_physiology0.90782395
117MP0001984_abnormal_olfaction0.90229796
118MP0004085_abnormal_heartbeat0.89275114
119MP0005395_other_phenotype0.87734642
120MP0001485_abnormal_pinna_reflex0.86470092
121MP0002735_abnormal_chemical_nociception0.85626408
122MP0005195_abnormal_posterior_eye0.84536986
123MP0003567_abnormal_fetal_cardiomyocyte0.84281109
124MP0001764_abnormal_homeostasis0.83551661
125MP0009764_decreased_sensitivity_to0.83364879
126MP0006276_abnormal_autonomic_nervous0.82676060
127MP0000230_abnormal_systemic_arterial0.82244174
128MP0005386_behavior/neurological_phenoty0.79547031
129MP0004924_abnormal_behavior0.79547031
130MP0005408_hypopigmentation0.79331150
131MP0002177_abnormal_outer_ear0.78544295
132MP0000613_abnormal_salivary_gland0.78428392
133MP0005310_abnormal_salivary_gland0.78049179
134MP0005083_abnormal_biliary_tract0.77462255
135MP0002736_abnormal_nociception_after0.77406395
136MP0002557_abnormal_social/conspecific_i0.77371644
137MP0001324_abnormal_eye_pigmentation0.76437645
138MP0003938_abnormal_ear_development0.76288338
139MP0009046_muscle_twitch0.76121685
140MP0003119_abnormal_digestive_system0.75680678
141MP0002572_abnormal_emotion/affect_behav0.75415391
142MP0002933_joint_inflammation0.74920381
143MP0002184_abnormal_innervation0.74811842
144MP0003868_abnormal_feces_composition0.74542804
145MP0001119_abnormal_female_reproductive0.74267427
146MP0009384_cardiac_valve_regurgitation0.74124968
147MP0000681_abnormal_thyroid_gland0.73076420
148MP0003763_abnormal_thymus_physiology0.72207411
149MP0010386_abnormal_urinary_bladder0.72034364
150MP0002067_abnormal_sensory_capabilities0.71058115
151MP0002229_neurodegeneration0.70405400
152MP0001968_abnormal_touch/_nociception0.70161216
153MP0002752_abnormal_somatic_nervous0.70018966
154MP0005464_abnormal_platelet_physiology0.70001166
155MP0001186_pigmentation_phenotype0.69826700
156MP0005647_abnormal_sex_gland0.68907390
157MP0001873_stomach_inflammation0.68474572
158MP0009745_abnormal_behavioral_response0.68082862

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.70675623
2Pancreatic fibrosis (HP:0100732)4.48065807
3Molar tooth sign on MRI (HP:0002419)4.26180938
4Abnormality of midbrain morphology (HP:0002418)4.26180938
5Nephronophthisis (HP:0000090)3.77478881
6Hypothermia (HP:0002045)3.72493258
7Patchy hypopigmentation of hair (HP:0011365)3.54024892
8White forelock (HP:0002211)3.42560999
9Type II lissencephaly (HP:0007260)3.40750325
10Abnormality of the renal medulla (HP:0100957)3.36236443
11Alveolar cell carcinoma (HP:0006519)3.11339086
12Parakeratosis (HP:0001036)3.07734986
13Submucous cleft hard palate (HP:0000176)2.98622726
14Cystic liver disease (HP:0006706)2.98164331
15Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.82266504
16Anomalous pulmonary venous return (HP:0010772)2.81177347
17Bile duct proliferation (HP:0001408)2.72790608
18Abnormal biliary tract physiology (HP:0012439)2.72790608
19Abnormality of the columella (HP:0009929)2.71361592
20Dynein arm defect of respiratory motile cilia (HP:0012255)2.65759916
21Absent/shortened dynein arms (HP:0200106)2.65759916
22Hyperventilation (HP:0002883)2.58738225
23Cerebellar dysplasia (HP:0007033)2.57210108
24Congenital hepatic fibrosis (HP:0002612)2.53686071
25Cupped ear (HP:0000378)2.53482760
26Duplicated collecting system (HP:0000081)2.52839905
27Congenital primary aphakia (HP:0007707)2.51517549
28Gait imbalance (HP:0002141)2.51020103
29Abnormality of the renal collecting system (HP:0004742)2.50736395
30Neoplasm of the tracheobronchial system (HP:0100552)2.48452602
31Sclerocornea (HP:0000647)2.48308237
32Renal cortical cysts (HP:0000803)2.47769083
33Tubular atrophy (HP:0000092)2.46816578
34Lissencephaly (HP:0001339)2.45140477
35Abnormal drinking behavior (HP:0030082)2.43851741
36Polydipsia (HP:0001959)2.43851741
37Nonprogressive disorder (HP:0003680)2.43585887
38Retrobulbar optic neuritis (HP:0100654)2.41730603
39Optic neuritis (HP:0100653)2.41730603
40Abnormality of the pulmonary veins (HP:0011718)2.41385826
41Abnormality of alanine metabolism (HP:0010916)2.41385444
42Hyperalaninemia (HP:0003348)2.41385444
43Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.41385444
44Tubulointerstitial nephritis (HP:0001970)2.41252448
45Acute necrotizing encephalopathy (HP:0006965)2.41241457
463-Methylglutaconic aciduria (HP:0003535)2.40284275
47Fair hair (HP:0002286)2.40175721
48Aplasia/Hypoplasia of the tongue (HP:0010295)2.39080301
49Abnormality of incisor morphology (HP:0011063)2.36207901
50Abnormality of the axillary hair (HP:0100134)2.32685501
51Abnormality of secondary sexual hair (HP:0009888)2.32685501
52Febrile seizures (HP:0002373)2.31756094
53Recurrent abscess formation (HP:0002722)2.26537189
54Aplasia/Hypoplasia of the uvula (HP:0010293)2.26103830
55Acute encephalopathy (HP:0006846)2.25739686
56Postaxial foot polydactyly (HP:0001830)2.23738299
57Increased CSF lactate (HP:0002490)2.23667806
58Congenital sensorineural hearing impairment (HP:0008527)2.23198681
59Mitochondrial inheritance (HP:0001427)2.22823143
60Abnormal ciliary motility (HP:0012262)2.22210365
61Progressive inability to walk (HP:0002505)2.22063934
62Septo-optic dysplasia (HP:0100842)2.21688454
63Anencephaly (HP:0002323)2.20686733
64Inability to walk (HP:0002540)2.19025995
65Aplasia/Hypoplasia of the tibia (HP:0005772)2.18676305
66Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.18270837
67Thyroid-stimulating hormone excess (HP:0002925)2.17686947
68Chronic diarrhea (HP:0002028)2.17530371
69Chromosomal breakage induced by crosslinking agents (HP:0003221)2.13836218
70Recurrent bacterial skin infections (HP:0005406)2.13582988
71Occipital encephalocele (HP:0002085)2.11910144
72Genital tract atresia (HP:0001827)2.11492335
73Type 2 muscle fiber atrophy (HP:0003554)2.11205322
74Decreased central vision (HP:0007663)2.11194955
75Male pseudohermaphroditism (HP:0000037)2.10440393
76Congenital stationary night blindness (HP:0007642)2.10338389
77Reduced antithrombin III activity (HP:0001976)2.10066658
78Hepatocellular necrosis (HP:0001404)2.09975206
79Vaginal atresia (HP:0000148)2.07620377
80Type I transferrin isoform profile (HP:0003642)2.07183754
81Hypoplasia of the iris (HP:0007676)2.07125979
82Hepatic necrosis (HP:0002605)2.06912969
83Progressive macrocephaly (HP:0004481)2.04797004
84Chronic hepatic failure (HP:0100626)2.03548667
85Abnormal mitochondria in muscle tissue (HP:0008316)2.03510203
86Poor coordination (HP:0002370)1.99818354
87Congenital, generalized hypertrichosis (HP:0004540)1.99159036
88Furrowed tongue (HP:0000221)1.98949737
89Polyuria (HP:0000103)1.98413475
90Recurrent skin infections (HP:0001581)1.98177283
91Generalized hypopigmentation of hair (HP:0011358)1.97614974
92Medial flaring of the eyebrow (HP:0010747)1.97442031
93Gaze-evoked nystagmus (HP:0000640)1.97153765
94True hermaphroditism (HP:0010459)1.96576352
95Toxemia of pregnancy (HP:0100603)1.96184273
96Recurrent pneumonia (HP:0006532)1.96031954
97Prolonged partial thromboplastin time (HP:0003645)1.95225539
98Absent septum pellucidum (HP:0001331)1.94451883
99Clumsiness (HP:0002312)1.92670987
100Preaxial hand polydactyly (HP:0001177)1.92241919
101Tubulointerstitial abnormality (HP:0001969)1.91408435
102Conjugated hyperbilirubinemia (HP:0002908)1.90767361
103Increased neuronal autofluorescent lipopigment (HP:0002074)1.90518899
104Abnormality of the pons (HP:0007361)1.90516383
105Abnormal hair whorl (HP:0010721)1.90116441
106Sloping forehead (HP:0000340)1.89223799
107Postaxial hand polydactyly (HP:0001162)1.88859377
108Attenuation of retinal blood vessels (HP:0007843)1.87124380
109Hypoplasia of the pons (HP:0012110)1.87098968
110Hypoplasia of the fovea (HP:0007750)1.86907232
111Aplasia/Hypoplasia of the fovea (HP:0008060)1.86907232
112Lipid accumulation in hepatocytes (HP:0006561)1.86867954
113Short tibia (HP:0005736)1.85484531
114Abnormality of the renal cortex (HP:0011035)1.84599207
115Supernumerary spleens (HP:0009799)1.83905277
116Absent rod-and cone-mediated responses on ERG (HP:0007688)1.83868210
117Blue irides (HP:0000635)1.83201091
118Widely spaced teeth (HP:0000687)1.82745266
119Broad-based gait (HP:0002136)1.82400135
120Abnormal respiratory epithelium morphology (HP:0012253)1.82351059
121Abnormal respiratory motile cilium morphology (HP:0005938)1.82351059
122Agammaglobulinemia (HP:0004432)1.82099912
123Dandy-Walker malformation (HP:0001305)1.81865193
124Chorioretinal atrophy (HP:0000533)1.81808618
125Prolonged neonatal jaundice (HP:0006579)1.81564194
126Upper limb muscle weakness (HP:0003484)1.81501109
127Myositis (HP:0100614)1.81361940
128Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.81151755
129Abnormal protein N-linked glycosylation (HP:0012347)1.81151755
130Abnormal protein glycosylation (HP:0012346)1.81151755
131Abnormal glycosylation (HP:0012345)1.81151755
132Myelomeningocele (HP:0002475)1.81084001
133Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.79833102
134Hyperglycinemia (HP:0002154)1.79197768
135Anophthalmia (HP:0000528)1.79132838
136Optic nerve hypoplasia (HP:0000609)1.78362380
137Retinal dysplasia (HP:0007973)1.77759951
138Abnormal rod and cone electroretinograms (HP:0008323)1.77677335
139Asplenia (HP:0001746)1.77598284
140Keratoconus (HP:0000563)1.77005909
141Increased corneal curvature (HP:0100692)1.77005909
142Small hand (HP:0200055)1.76531903
143Degeneration of the lateral corticospinal tracts (HP:0002314)1.76234754
144Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.76234754
145Aganglionic megacolon (HP:0002251)1.76137539
146Abnormality of macular pigmentation (HP:0008002)1.75831982
147Stomach cancer (HP:0012126)1.75703562
148Chromsome breakage (HP:0040012)1.75539335
149Abnormal respiratory motile cilium physiology (HP:0012261)1.75014363
150Microvesicular hepatic steatosis (HP:0001414)1.74909190
151Birth length less than 3rd percentile (HP:0003561)1.74501427
152Pulmonary artery stenosis (HP:0004415)1.74489494
153Dry hair (HP:0011359)1.74027513
154Optic disc pallor (HP:0000543)1.73587666
155Oculomotor apraxia (HP:0000657)1.73518373
156Abolished electroretinogram (ERG) (HP:0000550)1.73041318
157Abnormality of the septum pellucidum (HP:0007375)1.72769074
158Barrel-shaped chest (HP:0001552)1.72063394
159Ectropion (HP:0000656)1.71680743
160Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.71320250
161Abnormality of the ileum (HP:0001549)1.71034812
162Oligodactyly (hands) (HP:0001180)1.70686775
163Abnormality of chromosome stability (HP:0003220)1.70446576
164Astigmatism (HP:0000483)1.70427489
165Meckel diverticulum (HP:0002245)1.70295401
166Pachygyria (HP:0001302)1.69904675
167Conical tooth (HP:0000698)1.69748300
168Autoimmune hemolytic anemia (HP:0001890)1.66449915
169Orchitis (HP:0100796)1.65871040
170Protruding tongue (HP:0010808)1.65119991
171Osteomalacia (HP:0002749)1.65037528
172Nephrogenic diabetes insipidus (HP:0009806)1.64651924

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR24.13711916
2FRK3.60242540
3TNIK3.43032002
4MAP4K23.33288512
5CASK3.30893769
6ACVR1B2.53606969
7MAPK152.45230156
8BRSK22.34058757
9PNCK2.22010494
10MAP3K142.18898532
11IRAK42.16957874
12TXK2.16729632
13LATS12.13929054
14INSRR2.08046507
15EPHA31.95783422
16MAP3K41.94981147
17PINK11.91001704
18STK391.87614814
19PDK21.82640789
20PKN11.78913787
21ZAK1.78107535
22BMPR1B1.76894378
23NUAK11.75352550
24STK161.72945554
25WEE11.65718886
26ADRBK21.65542104
27IRAK11.65191106
28NEK61.62604447
29PRPF4B1.57351890
30NEK11.53303375
31IRAK31.52260676
32OXSR11.52067870
33PBK1.51894422
34GRK71.49241873
35GRK11.47964319
36PLK41.46878480
37STK38L1.44991961
38IRAK21.42067137
39CDK31.40559871
40IKBKB1.40136886
41EIF2AK21.32050628
42MAP3K131.30379961
43AKT31.30348519
44YES11.28920138
45TEC1.27223312
46MAPKAPK51.27188787
47MAPK131.26406792
48BLK1.23642171
49TRIM281.23506249
50TAF11.19883758
51MAP2K71.13231695
52IKBKE1.12159210
53PAK31.06994676
54EPHB11.05264144
55CDK81.04659564
56KIT1.03334339
57VRK11.02284207
58MKNK21.01835362
59CAMKK21.01587930
60BCR0.98742371
61CLK10.98106079
62MUSK0.97369238
63SGK2230.94921567
64SGK4940.94921567
65CSNK1G20.93244278
66BCKDK0.92851460
67ADRBK10.91620584
68NLK0.91605409
69CDC70.91177225
70ITK0.89457206
71TGFBR20.89363139
72CSNK1A1L0.84619166
73CSNK1G10.83501845
74PIK3CA0.81527131
75SRPK10.81476385
76MARK10.80873250
77CSNK1G30.79823278
78PRKCQ0.78527083
79PIK3CG0.77985759
80SGK20.77095668
81TLK10.76777636
82NTRK30.74285305
83TGFBR10.74129163
84RIPK40.72694476
85MKNK10.70804265
86CDK90.69812533
87TIE10.67649226
88PLK10.67591588
89PRKCG0.67027908
90CAMK2B0.66909275
91STK30.66281711
92VRK20.65119923
93PRKCE0.65096001
94SIK30.63503168
95TAOK30.63049019
96DAPK20.62226036
97PLK20.61371576
98NEK20.60108625
99WNK40.59940887
100CAMK1G0.58066516
101RPS6KA50.57678330
102ATR0.56671955
103DMPK0.56575089
104CHEK20.56233155
105DYRK20.55814431
106PLK30.55079512
107FES0.54848750
108LYN0.54790158
109BTK0.53339654
110MAPK70.51483508
111TRPM70.50357137
112MAP3K60.49098784
113CHUK0.47132990
114ATM0.46475822
115SYK0.46123811
116BRSK10.45999251
117PTK2B0.45657510
118DYRK1A0.45226401
119MARK20.44527986
120LCK0.44514278
121BRD40.44393997
122MST40.44136983
123CAMK2D0.43448518
124CSF1R0.42467480
125PRKG10.42082721
126PIM20.41541066
127JAK30.41294853
128GSK3A0.41111281
129WNK30.40790404
130BRAF0.40324832
131PRKACA0.37950867
132PHKG20.37949841
133PHKG10.37949841
134EIF2AK30.37719993
135HIPK20.37466732
136DYRK30.34692231
137ERBB30.34283837
138MAPKAPK30.34260284
139OBSCN0.33026134
140MAP3K120.32766104
141CSNK1A10.32307564
142AURKB0.32036067
143CAMK2A0.31491529
144CAMK2G0.31337956
145WNK10.30073636
146PRKAA20.29893238
147PRKACB0.29847048
148EIF2AK10.29488229
149CCNB10.27816229

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.59486163
2Steroid biosynthesis_Homo sapiens_hsa001003.00630700
3Protein export_Homo sapiens_hsa030602.94396349
4Oxidative phosphorylation_Homo sapiens_hsa001902.65789209
5Fatty acid elongation_Homo sapiens_hsa000622.55310608
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.37772189
7RNA polymerase_Homo sapiens_hsa030202.29965070
8Nitrogen metabolism_Homo sapiens_hsa009102.19295560
9Parkinsons disease_Homo sapiens_hsa050122.16856684
10Selenocompound metabolism_Homo sapiens_hsa004502.15887224
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.08554956
12Sphingolipid metabolism_Homo sapiens_hsa006002.08118261
13Ether lipid metabolism_Homo sapiens_hsa005652.03129498
14Phototransduction_Homo sapiens_hsa047442.02481016
15One carbon pool by folate_Homo sapiens_hsa006702.00370356
16SNARE interactions in vesicular transport_Homo sapiens_hsa041301.95494988
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.83653829
18Butanoate metabolism_Homo sapiens_hsa006501.83475799
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.78963809
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.77820915
21Huntingtons disease_Homo sapiens_hsa050161.67818772
22Mismatch repair_Homo sapiens_hsa034301.65362886
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.56798941
24Non-homologous end-joining_Homo sapiens_hsa034501.56427859
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.55870117
26Propanoate metabolism_Homo sapiens_hsa006401.53812880
27Autoimmune thyroid disease_Homo sapiens_hsa053201.53587856
28Tryptophan metabolism_Homo sapiens_hsa003801.52077329
29RNA degradation_Homo sapiens_hsa030181.48810349
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.46111988
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.45135826
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.43009664
33Glycosaminoglycan degradation_Homo sapiens_hsa005311.41541265
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38163003
35Ribosome_Homo sapiens_hsa030101.38078424
36Histidine metabolism_Homo sapiens_hsa003401.36386987
37Steroid hormone biosynthesis_Homo sapiens_hsa001401.35918777
38Vitamin digestion and absorption_Homo sapiens_hsa049771.34479659
39Allograft rejection_Homo sapiens_hsa053301.33449095
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.31782598
41Alzheimers disease_Homo sapiens_hsa050101.30433030
42Sulfur metabolism_Homo sapiens_hsa009201.27536850
43Rheumatoid arthritis_Homo sapiens_hsa053231.27467737
44RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.26479929
45Arachidonic acid metabolism_Homo sapiens_hsa005901.25864888
46Graft-versus-host disease_Homo sapiens_hsa053321.24663655
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.24249028
48Cardiac muscle contraction_Homo sapiens_hsa042601.23444364
49Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.22592786
50Olfactory transduction_Homo sapiens_hsa047401.21704789
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.19936073
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.19654736
53Nucleotide excision repair_Homo sapiens_hsa034201.19488121
54Toll-like receptor signaling pathway_Homo sapiens_hsa046201.16260033
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.14204876
56Purine metabolism_Homo sapiens_hsa002301.12497251
57Serotonergic synapse_Homo sapiens_hsa047261.11073738
58Taste transduction_Homo sapiens_hsa047421.10235467
59DNA replication_Homo sapiens_hsa030301.08696644
60ABC transporters_Homo sapiens_hsa020101.08628483
61Pyrimidine metabolism_Homo sapiens_hsa002401.07235472
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.06458988
63Primary immunodeficiency_Homo sapiens_hsa053401.05659809
64Morphine addiction_Homo sapiens_hsa050321.04729238
65RNA transport_Homo sapiens_hsa030131.04283402
66Fanconi anemia pathway_Homo sapiens_hsa034601.04101459
67Other glycan degradation_Homo sapiens_hsa005111.03802705
68Hematopoietic cell lineage_Homo sapiens_hsa046401.03767044
69NOD-like receptor signaling pathway_Homo sapiens_hsa046211.01627530
70Nicotine addiction_Homo sapiens_hsa050331.01038213
71Malaria_Homo sapiens_hsa051441.00557207
72Asthma_Homo sapiens_hsa053100.99881845
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.99527926
74Retinol metabolism_Homo sapiens_hsa008300.98348368
75Linoleic acid metabolism_Homo sapiens_hsa005910.98320626
76Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.95768065
77African trypanosomiasis_Homo sapiens_hsa051430.94872398
78Basal transcription factors_Homo sapiens_hsa030220.91909109
79Ovarian steroidogenesis_Homo sapiens_hsa049130.89181653
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83789877
81Fatty acid biosynthesis_Homo sapiens_hsa000610.83662877
82Axon guidance_Homo sapiens_hsa043600.83415426
83Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.82964167
84Alcoholism_Homo sapiens_hsa050340.82751162
85Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.82716976
86Measles_Homo sapiens_hsa051620.81887689
87Peroxisome_Homo sapiens_hsa041460.80189270
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.79933303
89Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.78618393
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.76224585
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74638188
92Circadian rhythm_Homo sapiens_hsa047100.74325387
93Glutamatergic synapse_Homo sapiens_hsa047240.73172661
94Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72512266
95Caffeine metabolism_Homo sapiens_hsa002320.70586014
96Hedgehog signaling pathway_Homo sapiens_hsa043400.70025769
97T cell receptor signaling pathway_Homo sapiens_hsa046600.68526650
98Collecting duct acid secretion_Homo sapiens_hsa049660.68401465
99beta-Alanine metabolism_Homo sapiens_hsa004100.68152008
100Staphylococcus aureus infection_Homo sapiens_hsa051500.67361310
101Leishmaniasis_Homo sapiens_hsa051400.66453311
102Base excision repair_Homo sapiens_hsa034100.65018483
103Proteasome_Homo sapiens_hsa030500.63767447
104Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62546894
105Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61715201
106Cysteine and methionine metabolism_Homo sapiens_hsa002700.59736709
107Phagosome_Homo sapiens_hsa041450.58079004
108Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57315792
109Osteoclast differentiation_Homo sapiens_hsa043800.56083939
110TGF-beta signaling pathway_Homo sapiens_hsa043500.56068073
111Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55665995
112Inositol phosphate metabolism_Homo sapiens_hsa005620.54906276
113Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54407873
114Lysosome_Homo sapiens_hsa041420.54266391
115Chemokine signaling pathway_Homo sapiens_hsa040620.53233747
116Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52372315
117Spliceosome_Homo sapiens_hsa030400.51720957
118Pertussis_Homo sapiens_hsa051330.51598252
119Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50839466
120Basal cell carcinoma_Homo sapiens_hsa052170.50254336
121Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49140696
122N-Glycan biosynthesis_Homo sapiens_hsa005100.48965119
123Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.47916622
124GABAergic synapse_Homo sapiens_hsa047270.47761480
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44863373
126Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43519378
127Calcium signaling pathway_Homo sapiens_hsa040200.42914738
128Cell cycle_Homo sapiens_hsa041100.42562548
129Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41681832
130p53 signaling pathway_Homo sapiens_hsa041150.41633608
131Regulation of autophagy_Homo sapiens_hsa041400.41519542
132Hepatitis C_Homo sapiens_hsa051600.41460945
133TNF signaling pathway_Homo sapiens_hsa046680.41175133
134Chemical carcinogenesis_Homo sapiens_hsa052040.41139471
135Homologous recombination_Homo sapiens_hsa034400.41128466
136Pancreatic secretion_Homo sapiens_hsa049720.41111883
137Pyruvate metabolism_Homo sapiens_hsa006200.39774718
138Type I diabetes mellitus_Homo sapiens_hsa049400.39445553
139Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37941200
140Hippo signaling pathway_Homo sapiens_hsa043900.37527296
141Metabolic pathways_Homo sapiens_hsa011000.37376811
142Folate biosynthesis_Homo sapiens_hsa007900.36935912
143Lysine degradation_Homo sapiens_hsa003100.36442757
144Fat digestion and absorption_Homo sapiens_hsa049750.36365430
145Systemic lupus erythematosus_Homo sapiens_hsa053220.34554068
146Circadian entrainment_Homo sapiens_hsa047130.34299740
147Herpes simplex infection_Homo sapiens_hsa051680.32655118
148Mineral absorption_Homo sapiens_hsa049780.31942984
149Primary bile acid biosynthesis_Homo sapiens_hsa001200.31398618
150Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.30004371

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