ST6GALNAC6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: ST6GALNAC6 belongs to a family of sialyltransferases that modify proteins and ceramides on the cell surface to alter cell-cell or cell-extracellular matrix interactions (Tsuchida et al., 2003 [PubMed 12668675]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)3.96379077
2synaptic vesicle maturation (GO:0016188)3.79254774
3bile acid and bile salt transport (GO:0015721)3.68338538
4regulation of short-term neuronal synaptic plasticity (GO:0048172)3.67856283
5regulation of ARF protein signal transduction (GO:0032012)3.62369640
6locomotory exploration behavior (GO:0035641)3.61007270
7cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.57193261
8sulfur amino acid catabolic process (GO:0000098)3.41290146
9glutamate secretion (GO:0014047)3.29999368
10negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.25184136
11sodium ion export (GO:0071436)3.24418516
12synaptic vesicle docking involved in exocytosis (GO:0016081)3.23308509
13barbed-end actin filament capping (GO:0051016)3.22571914
14dicarboxylic acid biosynthetic process (GO:0043650)3.18292147
15cell communication involved in cardiac conduction (GO:0086065)3.16401468
16cell communication by electrical coupling (GO:0010644)3.14376513
17erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.13411428
18L-phenylalanine catabolic process (GO:0006559)3.13411428
19kynurenine metabolic process (GO:0070189)3.12583258
20positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.11781113
21positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.11126691
22triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.09917683
23regulation of synapse structural plasticity (GO:0051823)3.06664469
24cytoskeletal anchoring at plasma membrane (GO:0007016)3.05468525
25erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.02754579
26L-phenylalanine metabolic process (GO:0006558)3.02754579
27cellular ketone body metabolic process (GO:0046950)3.00670748
28alpha-linolenic acid metabolic process (GO:0036109)2.99440971
29regulation of cholesterol homeostasis (GO:2000188)2.96803867
30positive regulation of synapse maturation (GO:0090129)2.95039541
31activation of protein kinase A activity (GO:0034199)2.93681054
32lysine metabolic process (GO:0006553)2.93280809
33lysine catabolic process (GO:0006554)2.93280809
34carnitine shuttle (GO:0006853)2.87350217
35neurotransmitter secretion (GO:0007269)2.84743849
36aromatic amino acid family catabolic process (GO:0009074)2.84667394
37fatty acid transmembrane transport (GO:1902001)2.84420377
38synaptic vesicle exocytosis (GO:0016079)2.80490822
39cellular potassium ion homeostasis (GO:0030007)2.77903536
40membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.77890780
41cerebellar granule cell differentiation (GO:0021707)2.72128980
42bile acid biosynthetic process (GO:0006699)2.71781018
43glutamate metabolic process (GO:0006536)2.71375849
44alanine transport (GO:0032328)2.71135463
45phospholipid homeostasis (GO:0055091)2.70345896
46gamma-aminobutyric acid transport (GO:0015812)2.69991482
47peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.69368000
48L-amino acid import (GO:0043092)2.69363951
49neurotransmitter-gated ion channel clustering (GO:0072578)2.68267300
50mannose metabolic process (GO:0006013)2.67344562
51high-density lipoprotein particle remodeling (GO:0034375)2.66081424
52negative regulation of fibrinolysis (GO:0051918)2.64448725
53indole-containing compound catabolic process (GO:0042436)2.63021621
54indolalkylamine catabolic process (GO:0046218)2.63021621
55tryptophan catabolic process (GO:0006569)2.63021621
56bile acid metabolic process (GO:0008206)2.62552206
57regulation of glutamate receptor signaling pathway (GO:1900449)2.62424472
58regulation of triglyceride catabolic process (GO:0010896)2.61771788
59positive regulation of lipid catabolic process (GO:0050996)2.61192527
60regulation of synaptic vesicle exocytosis (GO:2000300)2.60599919
61regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.60214858
62proline transport (GO:0015824)2.59461952
63positive regulation of fatty acid beta-oxidation (GO:0032000)2.58773845
64negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.58253746
65ketone body metabolic process (GO:1902224)2.57972794
66regulation of neuronal synaptic plasticity (GO:0048168)2.56981292
67glyoxylate metabolic process (GO:0046487)2.56678492
68complement activation, alternative pathway (GO:0006957)2.56671322
69regulation of synapse maturation (GO:0090128)2.56482899
70regulation of protein activation cascade (GO:2000257)2.55334384
71regulation of long-term neuronal synaptic plasticity (GO:0048169)2.55326926
72cellular sodium ion homeostasis (GO:0006883)2.54989063
73urea metabolic process (GO:0019627)2.54549125
74urea cycle (GO:0000050)2.54549125
75ethanol oxidation (GO:0006069)2.53665317
762-oxoglutarate metabolic process (GO:0006103)2.52012506
77protein carboxylation (GO:0018214)2.51753955
78peptidyl-glutamic acid carboxylation (GO:0017187)2.51753955
79amino acid import (GO:0043090)2.51747502
80positive regulation of protein dephosphorylation (GO:0035307)2.50760776
81negative regulation of sterol transport (GO:0032372)2.50704407
82negative regulation of cholesterol transport (GO:0032375)2.50704407
83exploration behavior (GO:0035640)2.49181477
84axonemal dynein complex assembly (GO:0070286)2.49061376
85protein localization to endosome (GO:0036010)2.48346115
86protein-lipid complex remodeling (GO:0034368)2.47887994
87macromolecular complex remodeling (GO:0034367)2.47887994
88plasma lipoprotein particle remodeling (GO:0034369)2.47887994
89negative regulation of erythrocyte differentiation (GO:0045647)2.47357368
90short-chain fatty acid metabolic process (GO:0046459)2.47323966
91positive regulation of fatty acid oxidation (GO:0046321)2.47235797
92stress fiber assembly (GO:0043149)2.47216237
93cellular glucuronidation (GO:0052695)2.46091395
94regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.45668982
95regulation of synaptic vesicle transport (GO:1902803)2.45176070
96dicarboxylic acid catabolic process (GO:0043649)2.43596835
97positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.43315468
98signal complex assembly (GO:0007172)2.43005860
99low-density lipoprotein particle clearance (GO:0034383)2.42995564
100protein targeting to plasma membrane (GO:0072661)2.42969892
101positive regulation of Rap GTPase activity (GO:0032854)2.42963315
102positive regulation of extracellular matrix organization (GO:1903055)2.42751203
103low-density lipoprotein particle remodeling (GO:0034374)2.42667644
104cardiac conduction (GO:0061337)2.42584999
105layer formation in cerebral cortex (GO:0021819)2.42394064
106extracellular fibril organization (GO:0043206)2.42002760
107regulation of fibrinolysis (GO:0051917)2.41932178
108ethanol metabolic process (GO:0006067)2.41930125
109fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.40994900
110aspartate family amino acid catabolic process (GO:0009068)2.40965135
111regulation of complement activation (GO:0030449)2.40154119
112tryptophan metabolic process (GO:0006568)2.40130280
113regulation of ARF GTPase activity (GO:0032312)2.39964063
114regulation of sodium ion transmembrane transporter activity (GO:2000649)2.39763143
115fibril organization (GO:0097435)2.39355321
116positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.38965939
117adenosine receptor signaling pathway (GO:0001973)2.38310748
118negative regulation of cell killing (GO:0031342)2.37652779
119negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.37652779
120potassium ion import (GO:0010107)2.36383881
121cellular modified amino acid catabolic process (GO:0042219)2.36254795
122tricarboxylic acid cycle (GO:0006099)2.36068765
123ventricular cardiac muscle cell action potential (GO:0086005)2.35985522
124regulation of fatty acid oxidation (GO:0046320)2.35131755
125glycine transport (GO:0015816)2.34513664
126succinate metabolic process (GO:0006105)2.34176841
127neuronal ion channel clustering (GO:0045161)2.32180684
128reverse cholesterol transport (GO:0043691)2.31978062
129cell volume homeostasis (GO:0006884)2.31811019
130positive regulation of fibroblast migration (GO:0010763)2.31804489
131regulation of fatty acid beta-oxidation (GO:0031998)2.31608182
132regulation of neurotransmitter levels (GO:0001505)2.31130483
133drug catabolic process (GO:0042737)2.30939005
134cellular response to epinephrine stimulus (GO:0071872)2.29562101
135neuromuscular process controlling balance (GO:0050885)2.27905488
136regulation of voltage-gated calcium channel activity (GO:1901385)2.27786892
137regulation of extracellular matrix disassembly (GO:0010715)2.27637892
138actin filament capping (GO:0051693)2.26864943
139regulation of synaptic plasticity (GO:0048167)2.26707980
140diacylglycerol metabolic process (GO:0046339)2.24399232
141apoptotic cell clearance (GO:0043277)2.24230861
142motile cilium assembly (GO:0044458)2.22567915
143negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.18187317
144protein heterotrimerization (GO:0070208)2.17160198
145regulation of early endosome to late endosome transport (GO:2000641)2.15199474
146cellular response to catecholamine stimulus (GO:0071870)2.14338136
147cellular response to monoamine stimulus (GO:0071868)2.14338136
148G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.12469966
149adherens junction assembly (GO:0034333)2.12348967
150focal adhesion assembly (GO:0048041)2.12096240
151cell-substrate adherens junction assembly (GO:0007045)2.12096240
152extracellular matrix assembly (GO:0085029)2.11665314
153cGMP-mediated signaling (GO:0019934)2.11283902
154positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.10994264
155positive regulation of dendritic spine development (GO:0060999)2.09450201
156positive regulation of receptor recycling (GO:0001921)2.08898633
157response to acidic pH (GO:0010447)2.04388031
158regulation of Rap GTPase activity (GO:0032317)2.03934781
159cortical actin cytoskeleton organization (GO:0030866)2.03848563
160negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.03735236
161acylglycerol catabolic process (GO:0046464)2.02707951
162neutral lipid catabolic process (GO:0046461)2.02707951
163regulation of response to osmotic stress (GO:0047484)2.01751347
164cilium or flagellum-dependent cell motility (GO:0001539)2.01480332
165potassium ion homeostasis (GO:0055075)2.00383977
166detection of calcium ion (GO:0005513)2.00036709
167regulation of T-helper 2 cell differentiation (GO:0045628)1.99118572
168dopamine receptor signaling pathway (GO:0007212)1.97094499
169positive regulation of membrane potential (GO:0045838)1.96867406
170regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)1.96652811
171triglyceride catabolic process (GO:0019433)1.95501201
172negative regulation of inclusion body assembly (GO:0090084)1.94146246
173peptidyl-tyrosine autophosphorylation (GO:0038083)1.92985925
174cAMP biosynthetic process (GO:0006171)1.92376231

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.62014828
2* RXR_22158963_ChIP-Seq_LIVER_Mouse3.27497172
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.83405171
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.76828542
5LXR_22158963_ChIP-Seq_LIVER_Mouse2.71917987
6DROSHA_22980978_ChIP-Seq_HELA_Human2.47737730
7EZH2_22144423_ChIP-Seq_EOC_Human2.32621319
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.28333255
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.23196916
10MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.21882702
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.14989062
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.11585856
13ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.88130783
14ELK3_25401928_ChIP-Seq_HUVEC_Human1.86774025
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.85834688
16RARB_27405468_Chip-Seq_BRAIN_Mouse1.85623388
17MTF2_20144788_ChIP-Seq_MESCs_Mouse1.84809835
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.84784137
19SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.84694573
20KDM2B_26808549_Chip-Seq_DND41_Human1.84230596
21EZH2_18974828_ChIP-Seq_MESCs_Mouse1.72947021
22RNF2_18974828_ChIP-Seq_MESCs_Mouse1.72947021
23KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.70103440
24* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68580172
25IKZF1_21737484_ChIP-ChIP_HCT116_Human1.66503234
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.64538530
27JARID2_20075857_ChIP-Seq_MESCs_Mouse1.63325921
28SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.62627517
29TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.62406772
30TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.59528748
31ERG_21242973_ChIP-ChIP_JURKAT_Human1.57777793
32EZH2_27294783_Chip-Seq_ESCs_Mouse1.56061427
33P68_20966046_ChIP-Seq_HELA_Human1.54891298
34VDR_21846776_ChIP-Seq_THP-1_Human1.54334445
35ESR1_20079471_ChIP-ChIP_T-47D_Human1.52330761
36SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.51717764
37SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.51649630
38* TCF7_22412390_ChIP-Seq_EML_Mouse1.50325884
39SUZ12_27294783_Chip-Seq_ESCs_Mouse1.49716845
40ESR2_21235772_ChIP-Seq_MCF-7_Human1.49210600
41JARID2_20064375_ChIP-Seq_MESCs_Mouse1.47048839
42REST_21632747_ChIP-Seq_MESCs_Mouse1.44856385
43SA1_27219007_Chip-Seq_ERYTHROID_Human1.42890762
44TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40603080
45ZNF263_19887448_ChIP-Seq_K562_Human1.40381298
46EGR1_23403033_ChIP-Seq_LIVER_Mouse1.38992231
47KDM2B_26808549_Chip-Seq_JURKAT_Human1.38697746
48UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.38669252
49NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.36810544
50RARG_19884340_ChIP-ChIP_MEFs_Mouse1.35719183
51DNAJC2_21179169_ChIP-ChIP_NT2_Human1.35059534
52BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.34411919
53CTCF_27219007_Chip-Seq_ERYTHROID_Human1.32956290
54CDX2_20551321_ChIP-Seq_CACO-2_Human1.32327855
55* LXR_22292898_ChIP-Seq_THP-1_Human1.31089207
56* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.30605695
57KDM2B_26808549_Chip-Seq_K562_Human1.28797969
58NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.28473034
59TET1_21451524_ChIP-Seq_MESCs_Mouse1.26438571
60REST_18959480_ChIP-ChIP_MESCs_Mouse1.26275891
61TP63_17297297_ChIP-ChIP_HaCaT_Human1.25257363
62FOXA2_19822575_ChIP-Seq_HepG2_Human1.23838522
63EED_16625203_ChIP-ChIP_MESCs_Mouse1.23098777
64E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.21157655
65* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.19621777
66RNF2_27304074_Chip-Seq_ESCs_Mouse1.17549657
67ELF1_20517297_ChIP-Seq_JURKAT_Human1.17004038
68ZFP281_27345836_Chip-Seq_ESCs_Mouse1.16000272
69GATA1_19941827_ChIP-Seq_MEL_Mouse1.15514407
70TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15432522
71TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.13210665
72ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.12745619
73ZFP281_18757296_ChIP-ChIP_E14_Mouse1.10819541
74GATA2_21666600_ChIP-Seq_HMVEC_Human1.10798448
75PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10573424
76VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.10072213
77EZH2_27304074_Chip-Seq_ESCs_Mouse1.09818807
78VDR_24763502_ChIP-Seq_THP-1_Human1.09442987
79TP63_22573176_ChIP-Seq_HFKS_Human1.09411318
80SMC1_22415368_ChIP-Seq_MEFs_Mouse1.07555561
81SA1_27219007_Chip-Seq_Bcells_Human1.07069224
82GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05853498
83KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.05420125
84SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.04814156
85CTCF_27219007_Chip-Seq_Bcells_Human1.03350326
86* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.03309255
87SRY_22984422_ChIP-ChIP_TESTIS_Rat1.03165124
88RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.02769637
89WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02426411
90GBX2_23144817_ChIP-Seq_PC3_Human1.02414911
91SOX2_27498859_Chip-Seq_STOMACH_Mouse1.02291028
92STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.02239491
93EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.01607817
94EP300_21415370_ChIP-Seq_HL-1_Mouse1.01355859
95BCOR_27268052_Chip-Seq_Bcells_Human1.01068526
96ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00374396
97* BCL6_27268052_Chip-Seq_Bcells_Human1.00041940
98* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.99792749
99* TP53_23651856_ChIP-Seq_MEFs_Mouse0.99347822
100MAF_26560356_Chip-Seq_TH1_Human0.99110117
101P300_27058665_Chip-Seq_ZR-75-30cells_Human0.98968615
102* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.98849699
103MAF_26560356_Chip-Seq_TH2_Human0.98754248
104NR3C1_23031785_ChIP-Seq_PC12_Mouse0.97536457
105ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.97441811
106MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.95724399
107TRIM28_21343339_ChIP-Seq_HEK293_Human0.95662986
108PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.94670290
109SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93057462
110NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.92260740
111ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91595453
112RACK7_27058665_Chip-Seq_MCF-7_Human0.91371944
113RXR_22108803_ChIP-Seq_LS180_Human0.91076054
114CLOCK_20551151_ChIP-Seq_293T_Human0.91034933
115BCAT_22108803_ChIP-Seq_LS180_Human0.90984355
116RING1B_27294783_Chip-Seq_ESCs_Mouse0.90456333
117* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88709479
118PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.88126811
119RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.87629082
120CREB1_26743006_Chip-Seq_LNCaP_Human0.87543221
121SMAD3_21741376_ChIP-Seq_HESCs_Human0.86497748
122ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86420409
123* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.86150085
124SMAD4_21741376_ChIP-Seq_HESCs_Human0.85903688
125ESR1_21235772_ChIP-Seq_MCF-7_Human0.85863529
126AR_19668381_ChIP-Seq_PC3_Human0.85130160
127ZNF274_21170338_ChIP-Seq_K562_Hela0.84787133
128TBX20_22080862_ChIP-Seq_HEART_Mouse0.84566574
129TBX20_22328084_ChIP-Seq_HEART_Mouse0.84566574
130TET1_21490601_ChIP-Seq_MESCs_Mouse0.83697307
131ESR1_15608294_ChIP-ChIP_MCF-7_Human0.82269146
132CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.81919678
133SOX2_20726797_ChIP-Seq_SW620_Human0.81625559
134NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.81290341
135NRF2_20460467_ChIP-Seq_MEFs_Mouse0.81290341
136* SOX2_21211035_ChIP-Seq_LN229_Gbm0.80484789
137GATA1_19941826_ChIP-Seq_K562_Human0.80151662
138SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.80134402
139SMC4_20622854_ChIP-Seq_HELA_Human0.79455713
140CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.79421814
141SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.77849808
142NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.77794390
143TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.76027655
144AHR_22903824_ChIP-Seq_MCF-7_Human0.74486664

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.41474331
2MP0010234_abnormal_vibrissa_follicle4.00278402
3MP0002822_catalepsy3.76886664
4MP0002139_abnormal_hepatobiliary_system3.73321653
5MP0005085_abnormal_gallbladder_physiolo3.68215011
6MP0005360_urolithiasis3.47378956
7MP0005365_abnormal_bile_salt3.08360678
8MP0008438_abnormal_cutaneous_collagen2.97839367
9MP0002837_dystrophic_cardiac_calcinosis2.76348052
10MP0001958_emphysema2.68954249
11MP0008875_abnormal_xenobiotic_pharmacok2.50691979
12MP0003252_abnormal_bile_duct2.35989989
13MP0003635_abnormal_synaptic_transmissio2.29408520
14MP0003279_aneurysm2.27633757
15MP0010329_abnormal_lipoprotein_level2.24493213
16MP0003705_abnormal_hypodermis_morpholog2.14154233
17MP0002909_abnormal_adrenal_gland2.09980561
18MP0004270_analgesia2.09263291
19MP0000751_myopathy2.02970694
20MP0005670_abnormal_white_adipose1.93627990
21MP0005503_abnormal_tendon_morphology1.90889319
22MP0009780_abnormal_chondrocyte_physiolo1.86168227
23MP0004130_abnormal_muscle_cell1.84257633
24MP0005167_abnormal_blood-brain_barrier1.82237233
25MP0005623_abnormal_meninges_morphology1.81939056
26MP0009840_abnormal_foam_cell1.78685147
27MP0009745_abnormal_behavioral_response1.77330609
28MP0002063_abnormal_learning/memory/cond1.76860607
29MP0003329_amyloid_beta_deposits1.76689060
30MP0005423_abnormal_somatic_nervous1.72738617
31MP0005058_abnormal_lysosome_morphology1.71263306
32MP0004858_abnormal_nervous_system1.60550293
33MP0000604_amyloidosis1.59763926
34MP0005275_abnormal_skin_tensile1.57595153
35MP0003806_abnormal_nucleotide_metabolis1.57124889
36MP0004215_abnormal_myocardial_fiber1.56740924
37MP0005409_darkened_coat_color1.56697042
38MP0001501_abnormal_sleep_pattern1.53536689
39MP0002064_seizures1.53112101
40MP0003303_peritoneal_inflammation1.51991634
41MP0003075_altered_response_to1.51926875
42MP0003172_abnormal_lysosome_physiology1.51592356
43MP0004084_abnormal_cardiac_muscle1.51506805
44MP0003646_muscle_fatigue1.50516341
45MP0002933_joint_inflammation1.49826075
46MP0002118_abnormal_lipid_homeostasis1.48695141
47MP0005083_abnormal_biliary_tract1.47295791
48MP0001666_abnormal_nutrient_absorption1.47234462
49MP0003191_abnormal_cellular_cholesterol1.46232377
50MP0009046_muscle_twitch1.45122834
51MP0004036_abnormal_muscle_relaxation1.44789708
52MP0003195_calcinosis1.41445129
53MP0005332_abnormal_amino_acid1.39071803
54MP0000920_abnormal_myelination1.38514917
55MP0003436_decreased_susceptibility_to1.38241495
56MP0003724_increased_susceptibility_to1.36639267
57MP0003091_abnormal_cell_migration1.35863342
58MP0003283_abnormal_digestive_organ1.35611940
59MP0005375_adipose_tissue_phenotype1.29642623
60MP0001968_abnormal_touch/_nociception1.26752958
61MP0002734_abnormal_mechanical_nocicepti1.26203493
62MP0003566_abnormal_cell_adhesion1.25612251
63MP0003879_abnormal_hair_cell1.24657109
64MP0002572_abnormal_emotion/affect_behav1.24231906
65MP0002272_abnormal_nervous_system1.22323488
66MP0001849_ear_inflammation1.22123791
67MP0005584_abnormal_enzyme/coenzyme_acti1.21514710
68MP0000013_abnormal_adipose_tissue1.21113896
69MP0003868_abnormal_feces_composition1.19575215
70MP0003880_abnormal_central_pattern1.17901473
71MP0002269_muscular_atrophy1.15789417
72MP0010368_abnormal_lymphatic_system1.14592774
73MP0005330_cardiomyopathy1.14465341
74MP0008569_lethality_at_weaning1.13071529
75MP0003690_abnormal_glial_cell1.12716676
76MP0005319_abnormal_enzyme/_coenzyme1.12657079
77MP0001486_abnormal_startle_reflex1.12501034
78MP0001440_abnormal_grooming_behavior1.11797636
79MP0000003_abnormal_adipose_tissue1.11588457
80MP0008260_abnormal_autophagy1.10939186
81MP0004272_abnormal_basement_membrane1.10480138
82MP0001348_abnormal_lacrimal_gland1.10129495
83MP0003633_abnormal_nervous_system1.09000051
84MP0002998_abnormal_bone_remodeling1.07504779
85MP0000749_muscle_degeneration1.06605165
86MP0002133_abnormal_respiratory_system1.05725561
87MP0005388_respiratory_system_phenotype1.05725561
88MP0003137_abnormal_impulse_conducting1.05594447
89MP0005166_decreased_susceptibility_to1.05516384
90MP0001533_abnormal_skeleton_physiology1.04944371
91MP0004087_abnormal_muscle_fiber1.04672605
92MP0005165_increased_susceptibility_to1.04604369
93MP0002295_abnormal_pulmonary_circulatio1.03991988
94MP0005620_abnormal_muscle_contractility1.02517307
95MP0005595_abnormal_vascular_smooth1.02037672
96MP0002972_abnormal_cardiac_muscle1.01411089
97MP0004484_altered_response_of1.01374120
98MP0003828_pulmonary_edema1.01332740
99MP0000609_abnormal_liver_physiology0.99759853
100MP0008874_decreased_physiological_sensi0.99692572
101MP0005535_abnormal_body_temperature0.98932873
102MP0003866_abnormal_defecation0.98135284
103MP0008872_abnormal_physiological_respon0.97925222
104MP0000767_abnormal_smooth_muscle0.96719233
105MP0004043_abnormal_pH_regulation0.96309348
106MP0003300_gastrointestinal_ulcer0.96253986
107MP0003634_abnormal_glial_cell0.95633597
108MP0000681_abnormal_thyroid_gland0.95552151
109MP0002736_abnormal_nociception_after0.94632697
110MP0008775_abnormal_heart_ventricle0.94042982
111MP0004085_abnormal_heartbeat0.93048308
112MP0005386_behavior/neurological_phenoty0.91802192
113MP0004924_abnormal_behavior0.91802192
114MP0000759_abnormal_skeletal_muscle0.91267766
115MP0008961_abnormal_basal_metabolism0.91194556
116MP0004947_skin_inflammation0.90099709
117MP0002733_abnormal_thermal_nociception0.88854044
118MP0001986_abnormal_taste_sensitivity0.85618826
119MP0005666_abnormal_adipose_tissue0.85383323
120MP0000747_muscle_weakness0.84085061
121MP0002078_abnormal_glucose_homeostasis0.83178197
122MP0000249_abnormal_blood_vessel0.81664462
123MP0004811_abnormal_neuron_physiology0.81046174
124MP0001970_abnormal_pain_threshold0.80876911
125MP0000230_abnormal_systemic_arterial0.79327052
126MP0004510_myositis0.79191203
127MP0001765_abnormal_ion_homeostasis0.79167729
128MP0000343_altered_response_to0.79073460
129MP0003763_abnormal_thymus_physiology0.79067613
130MP0004019_abnormal_vitamin_homeostasis0.78854020
131MP0006138_congestive_heart_failure0.78801671
132MP0001664_abnormal_digestion0.78662122
133MP0000858_altered_metastatic_potential0.78641014
134MP0002971_abnormal_brown_adipose0.78543569
135MP0002249_abnormal_larynx_morphology0.78467769
136MP0005390_skeleton_phenotype0.78414389
137MP0005385_cardiovascular_system_phenoty0.78205946
138MP0001544_abnormal_cardiovascular_syste0.78205946
139MP0002090_abnormal_vision0.76532770
140MP0004185_abnormal_adipocyte_glucose0.75634433
141MP0005023_abnormal_wound_healing0.75203712
142MP0005187_abnormal_penis_morphology0.74837160
143MP0003045_fibrosis0.73893578
144MP0001663_abnormal_digestive_system0.73836520
145MP0001542_abnormal_bone_strength0.73615594
146MP0005508_abnormal_skeleton_morphology0.73587561
147MP0002896_abnormal_bone_mineralization0.72349670
148MP0004145_abnormal_muscle_electrophysio0.72330023
149MP0003631_nervous_system_phenotype0.70722458
150MP0002108_abnormal_muscle_morphology0.69824363
151MP0001502_abnormal_circadian_rhythm0.68803899
152MP0001851_eye_inflammation0.68310167
153MP0006036_abnormal_mitochondrial_physio0.67060627
154MP0002089_abnormal_postnatal_growth/wei0.66775943
155MP0006082_CNS_inflammation0.66694541

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.27607688
2Deep venous thrombosis (HP:0002625)4.05653809
3Protrusio acetabuli (HP:0003179)4.01932330
4Bundle branch block (HP:0011710)3.71038914
5Obstructive sleep apnea (HP:0002870)3.56095913
6Intrahepatic cholestasis (HP:0001406)3.45486766
7Xanthomatosis (HP:0000991)3.33144599
8Abnormality of the nasal mucosa (HP:0000433)3.31466089
9Ventricular fibrillation (HP:0001663)3.17212036
10Sudden death (HP:0001699)3.17190508
11Increased variability in muscle fiber diameter (HP:0003557)3.15659314
12Right ventricular cardiomyopathy (HP:0011663)3.13265197
13Neurofibrillary tangles (HP:0002185)3.10373128
14Focal motor seizures (HP:0011153)3.09359774
15Supranuclear gaze palsy (HP:0000605)3.07808882
16Abnormality of monocarboxylic acid metabolism (HP:0010996)3.04408789
17Exercise-induced myalgia (HP:0003738)3.02254090
18Nasal polyposis (HP:0100582)3.02112391
19Aortic aneurysm (HP:0004942)3.00805592
20Vascular tortuosity (HP:0004948)3.00298799
21Abnormality of aromatic amino acid family metabolism (HP:0004338)2.99961292
22Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.97581334
23Action tremor (HP:0002345)2.92657133
24Syncope (HP:0001279)2.89839498
25Heart block (HP:0012722)2.89787796
26Myoglobinuria (HP:0002913)2.87454581
27Hyperlipoproteinemia (HP:0010980)2.86192284
28Ankle clonus (HP:0011448)2.85876828
29Dysmetric saccades (HP:0000641)2.82238731
30Visual hallucinations (HP:0002367)2.81456915
31Complement deficiency (HP:0004431)2.81414190
32Premature rupture of membranes (HP:0001788)2.80675153
33Abnormal atrioventricular conduction (HP:0005150)2.76456676
34Arterial tortuosity (HP:0005116)2.75249813
35Annular pancreas (HP:0001734)2.74942657
36Hypoglycemic coma (HP:0001325)2.74823498
37Cerebral aneurysm (HP:0004944)2.70282626
38Ketosis (HP:0001946)2.70233453
39Hyperammonemia (HP:0001987)2.69925574
40Abnormality of skeletal muscle fiber size (HP:0012084)2.67940199
41Exercise-induced muscle cramps (HP:0003710)2.67144358
42Abnormality of binocular vision (HP:0011514)2.66300585
43Diplopia (HP:0000651)2.66300585
44Papilledema (HP:0001085)2.64198643
45Focal seizures (HP:0007359)2.61828269
46Ketoacidosis (HP:0001993)2.56050996
47Hypoalphalipoproteinemia (HP:0003233)2.55778942
48Prolonged partial thromboplastin time (HP:0003645)2.54924181
49Cerebral inclusion bodies (HP:0100314)2.54068611
50Vertebral compression fractures (HP:0002953)2.53328248
51Atrioventricular block (HP:0001678)2.52434237
52Prolonged QT interval (HP:0001657)2.44205944
53Aortic dissection (HP:0002647)2.41750543
54Ventricular arrhythmia (HP:0004308)2.38987737
55Abnormality of the lower motor neuron (HP:0002366)2.38739464
56Impaired social interactions (HP:0000735)2.35600095
57Abnormal social behavior (HP:0012433)2.35600095
58Abnormal respiratory epithelium morphology (HP:0012253)2.34732184
59Abnormal respiratory motile cilium morphology (HP:0005938)2.34732184
60Torticollis (HP:0000473)2.33659079
61Spinal rigidity (HP:0003306)2.33411447
62Abnormal respiratory motile cilium physiology (HP:0012261)2.33299232
63Palpitations (HP:0001962)2.31715251
64Dynein arm defect of respiratory motile cilia (HP:0012255)2.31104821
65Absent/shortened dynein arms (HP:0200106)2.31104821
66Rhinitis (HP:0012384)2.30294501
67Atelectasis (HP:0100750)2.27980238
68Dilatation of the ascending aorta (HP:0005111)2.27634916
69Distal upper limb amyotrophy (HP:0007149)2.25913278
70Upper limb amyotrophy (HP:0009129)2.25913278
71Turricephaly (HP:0000262)2.24103075
72Hemorrhage of the eye (HP:0011885)2.22664042
73Type 1 muscle fiber predominance (HP:0003803)2.21885216
74Epidermoid cyst (HP:0200040)2.21820194
75Postural instability (HP:0002172)2.21435475
76Abnormality of glutamine family amino acid metabolism (HP:0010902)2.20878578
77Dysostosis multiplex (HP:0000943)2.19833085
78Sensorimotor neuropathy (HP:0007141)2.19199006
79Hypolipoproteinemia (HP:0010981)2.18832006
80Skin nodule (HP:0200036)2.18390279
81Abnormal ciliary motility (HP:0012262)2.17934345
82Hypobetalipoproteinemia (HP:0003563)2.17058067
83Mildly elevated creatine phosphokinase (HP:0008180)2.15489456
84Pheochromocytoma (HP:0002666)2.14090573
85Abnormal EKG (HP:0003115)2.13223227
86Focal dystonia (HP:0004373)2.12762224
87Hyperglycinemia (HP:0002154)2.11991869
88Abnormality of mucopolysaccharide metabolism (HP:0011020)2.11874289
89Abnormality of polysaccharide metabolism (HP:0011012)2.11874289
90Abnormality of glycosaminoglycan metabolism (HP:0004371)2.11874289
91Atrial fibrillation (HP:0005110)2.10663892
92Mucopolysacchariduria (HP:0008155)2.10385197
93Urinary glycosaminoglycan excretion (HP:0003541)2.10385197
94Ventricular tachycardia (HP:0004756)2.09461340
95Hyperactive renin-angiotensin system (HP:0000841)2.09347234
96Poor eye contact (HP:0000817)2.08698678
97Centrally nucleated skeletal muscle fibers (HP:0003687)2.08048854
98Abnormality of the Achilles tendon (HP:0005109)2.07867788
99Cholelithiasis (HP:0001081)2.07412887
100Abnormal gallbladder physiology (HP:0012438)2.06812126
101Cholecystitis (HP:0001082)2.06812126
102Status epilepticus (HP:0002133)2.06159606
103Shallow orbits (HP:0000586)2.05881231
104Dysdiadochokinesis (HP:0002075)2.04922204
105Axonal loss (HP:0003447)2.04787107
106Hyperglycinuria (HP:0003108)2.04202718
107Muscle fiber splitting (HP:0003555)2.03738934
108Distal lower limb muscle weakness (HP:0009053)2.03587138
109Craniofacial dystonia (HP:0012179)2.02722574
110Gout (HP:0001997)2.02672512
111Generalized tonic-clonic seizures (HP:0002069)2.02640752
112Abnormality of the common coagulation pathway (HP:0010990)2.02464877
113Primary atrial arrhythmia (HP:0001692)2.02264292
114Stridor (HP:0010307)2.02009509
115Cervical subluxation (HP:0003308)2.00740023
116Neonatal onset (HP:0003623)1.99684529
117Late onset (HP:0003584)1.98747594
118Aneurysm (HP:0002617)1.98145474
119Abnormality of complement system (HP:0005339)1.97734562
120Abnormal gallbladder morphology (HP:0012437)1.96132354
121Abnormality of fatty-acid metabolism (HP:0004359)1.95742388
122Hypercortisolism (HP:0001578)1.95684650
123Neuronal loss in central nervous system (HP:0002529)1.95150804
124Bladder diverticulum (HP:0000015)1.94119559
125Anxiety (HP:0000739)1.94030980
126Neonatal short-limb short stature (HP:0008921)1.93263466
127Spinal cord compression (HP:0002176)1.93044743
128Spontaneous abortion (HP:0005268)1.92372314
129Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.91798467
130Myotonia (HP:0002486)1.91351168
131Ileus (HP:0002595)1.90968448
132Truncal ataxia (HP:0002078)1.90959036
133Depression (HP:0000716)1.89836186
134Growth hormone excess (HP:0000845)1.89326620
135Systemic lupus erythematosus (HP:0002725)1.89200312
136Hyporeflexia of lower limbs (HP:0002600)1.88965037
137Emphysema (HP:0002097)1.87888641
138Polygenic inheritance (HP:0010982)1.87209164
139Impaired vibration sensation in the lower limbs (HP:0002166)1.87002225
140Abnormality of glycine metabolism (HP:0010895)1.86854136
141Abnormality of serine family amino acid metabolism (HP:0010894)1.86854136
142Wormian bones (HP:0002645)1.86712934
143Supraventricular tachycardia (HP:0004755)1.85904068
144Rapidly progressive (HP:0003678)1.85585427
145Epileptic encephalopathy (HP:0200134)1.85026453
146Hand muscle atrophy (HP:0009130)1.84352702
147Broad metatarsal (HP:0001783)1.84291937
148Flat acetabular roof (HP:0003180)1.83995902
149Abnormal eating behavior (HP:0100738)1.83897347
150Stroke (HP:0001297)1.83832286
151Asymmetric septal hypertrophy (HP:0001670)1.83313699
152Supraventricular arrhythmia (HP:0005115)1.81460722
153EMG: myopathic abnormalities (HP:0003458)1.81447575
154Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.80661772
155Joint stiffness (HP:0001387)1.80410914
156Achilles tendon contracture (HP:0001771)1.79558367
157Thin bony cortex (HP:0002753)1.79434874
158Chronic bronchitis (HP:0004469)1.79182146
159Increased connective tissue (HP:0009025)1.78593622
160Muscle stiffness (HP:0003552)1.77143165
161Urinary bladder sphincter dysfunction (HP:0002839)1.76731484
162Hemiplegia (HP:0002301)1.75346218
163Long toe (HP:0010511)1.74694510
164Hyperventilation (HP:0002883)1.74338042
165Abnormality of the intrinsic pathway (HP:0010989)1.74190024
166Foot dorsiflexor weakness (HP:0009027)1.73990294
167Abnormality of dicarboxylic acid metabolism (HP:0010995)1.73660760
168Dicarboxylic aciduria (HP:0003215)1.73660760
169Mitral regurgitation (HP:0001653)1.72824585
170Hypertriglyceridemia (HP:0002155)1.72658361
171Progressive cerebellar ataxia (HP:0002073)1.72315086
172Tetraplegia (HP:0002445)1.71591560
173Mitral stenosis (HP:0001718)1.71506529
174Akinesia (HP:0002304)1.71131985
175Bronchiectasis (HP:0002110)1.70989541
176Rhabdomyolysis (HP:0003201)1.70911171
177Blue sclerae (HP:0000592)1.69017580
178Insomnia (HP:0100785)1.67083734
179Acanthosis nigricans (HP:0000956)1.66922677
180Hypoventilation (HP:0002791)1.66655952

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK13.13349669
2EPHA43.11966938
3LMTK22.74422826
4MAP3K92.62324925
5PIK3CA2.55480313
6TRIB32.41576573
7DAPK22.39321238
8KSR22.36027002
9CAMKK12.24894156
10NTRK32.23175937
11PKN22.11958251
12MAPK152.06002944
13PRKD32.02610941
14TAOK11.89868327
15PAK61.84942787
16FRK1.75284471
17PHKG21.68351474
18PHKG11.68351474
19MAP2K41.59188396
20MINK11.55639649
21MARK21.50471660
22MAP3K41.47837716
23TTN1.43534170
24NEK11.43167522
25ICK1.42398469
26MAP3K71.41408717
27NTRK11.40306513
28SIK11.40304907
29STK381.38213240
30EEF2K1.36990576
31MYLK1.36277063
32PINK11.35325073
33MAP3K21.33842676
34RIPK41.32140402
35DMPK1.31660108
36TESK11.31089011
37MST1R1.24092626
38SMG11.17257412
39FGFR41.15521241
40FES1.13245250
41SGK31.10852016
42UHMK11.10678568
43MARK11.08888823
44BCKDK1.07981083
45ZAP701.07192558
46GRK61.06137194
47PDPK11.04240901
48EPHB11.03783372
49PRKD21.01725332
50MAP4K11.00418071
51RET0.98592787
52PRKCH0.97861744
53PAK30.96584684
54MAP3K10.96350816
55CAMKK20.95382932
56PDK10.93406403
57DAPK10.93287518
58CDK50.93283205
59PDK40.92513258
60PDK30.92513258
61LATS20.92051498
62CAMK2D0.91464564
63MAP3K130.91011815
64PTK60.90828299
65MAP2K10.90720951
66ERN10.90476981
67PDGFRA0.89372635
68ARAF0.86007508
69TBK10.85201748
70MAP2K30.83965316
71STK110.81483256
72TYK20.81261995
73DAPK30.80387857
74SGK20.80209121
75TGFBR20.79065440
76PRKCG0.78595711
77MAP2K70.77891073
78CDC42BPA0.77870120
79MAPK70.77583004
80CSK0.77417464
81TAOK20.75917741
82RPS6KA20.75859612
83ALK0.74434699
84MOS0.73868749
85BMX0.72797470
86CAMK10.72647296
87KSR10.72557942
88PRPF4B0.72064676
89GRK50.71151510
90SGK2230.70709476
91SGK4940.70709476
92PRKG20.70166021
93DDR20.68359555
94PTK2B0.68258346
95CAMK2G0.65890421
96TNK20.65501009
97MAPKAPK30.65110955
98PTK20.64072952
99CAMK2A0.62380916
100NTRK20.62321117
101MAP3K30.62313601
102PRKAA10.58309711
103MAPK40.57520944
104OBSCN0.57304263
105HIPK20.56505102
106PRKCZ0.55526281
107EPHB20.55073949
108FGFR30.55002704
109TYRO30.54590951
110MAP3K120.54297099
111MAP2K20.53999701
112ROCK10.53995219
113MAP2K60.52990425
114LIMK10.52948922
115PRKACG0.52862680
116SGK10.52585321
117CAMK40.52263863
118PRKD10.49877356
119NME10.48971912
120DYRK1B0.48609322
121JAK10.47966000
122ROCK20.47659979
123INSRR0.46149347
124MAPK120.45100855
125JAK20.44733942
126TIE10.44214826
127PDGFRB0.44104649
128SIK20.43590277
129CAMK2B0.43546257
130MAP3K110.43345703
131ERBB20.43246538
132PRKAA20.42640021
133MAPK110.42282612
134RAF10.42111541

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.55133336
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.07223187
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.46538241
4Arginine biosynthesis_Homo sapiens_hsa002202.36902189
5Bile secretion_Homo sapiens_hsa049762.05671061
6Fatty acid degradation_Homo sapiens_hsa000711.91982977
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.89534015
8Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.86504356
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.82461916
10Butanoate metabolism_Homo sapiens_hsa006501.71108945
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.70959022
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.64935897
13Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.64820163
14Sulfur metabolism_Homo sapiens_hsa009201.56257298
15Tryptophan metabolism_Homo sapiens_hsa003801.54374429
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.48139483
17Olfactory transduction_Homo sapiens_hsa047401.46499259
18Glycosaminoglycan degradation_Homo sapiens_hsa005311.45358375
19Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.43675714
20PPAR signaling pathway_Homo sapiens_hsa033201.43252137
21Propanoate metabolism_Homo sapiens_hsa006401.43124138
22Fatty acid metabolism_Homo sapiens_hsa012121.37815150
23Synaptic vesicle cycle_Homo sapiens_hsa047211.37476026
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.36408452
25Other glycan degradation_Homo sapiens_hsa005111.30733048
26Circadian entrainment_Homo sapiens_hsa047131.28678953
27Salivary secretion_Homo sapiens_hsa049701.27113218
28GABAergic synapse_Homo sapiens_hsa047271.26615519
29Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.24377483
30Phospholipase D signaling pathway_Homo sapiens_hsa040721.23142931
31Complement and coagulation cascades_Homo sapiens_hsa046101.18354378
32Insulin secretion_Homo sapiens_hsa049111.17234105
33VEGF signaling pathway_Homo sapiens_hsa043701.17133017
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14814872
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12006143
36Nicotine addiction_Homo sapiens_hsa050331.11825349
37Aldosterone synthesis and secretion_Homo sapiens_hsa049251.11519120
38Carbon metabolism_Homo sapiens_hsa012001.10945115
39Gastric acid secretion_Homo sapiens_hsa049711.08591082
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.08122961
41Long-term potentiation_Homo sapiens_hsa047201.07717027
42Neurotrophin signaling pathway_Homo sapiens_hsa047221.05679973
43Glutamatergic synapse_Homo sapiens_hsa047241.04099475
44Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.02584473
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.98563469
46Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.98547067
47Morphine addiction_Homo sapiens_hsa050320.97301921
48Starch and sucrose metabolism_Homo sapiens_hsa005000.95399170
49Leukocyte transendothelial migration_Homo sapiens_hsa046700.95241219
50Amphetamine addiction_Homo sapiens_hsa050310.94901002
51Dilated cardiomyopathy_Homo sapiens_hsa054140.94742702
52Type II diabetes mellitus_Homo sapiens_hsa049300.94300470
53Cholinergic synapse_Homo sapiens_hsa047250.91825174
54Pyruvate metabolism_Homo sapiens_hsa006200.90711014
55Endocytosis_Homo sapiens_hsa041440.89985164
56Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.89819384
57Cardiac muscle contraction_Homo sapiens_hsa042600.89710138
58AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89597495
59Focal adhesion_Homo sapiens_hsa045100.89080310
60Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.86907275
61Renin secretion_Homo sapiens_hsa049240.86661957
62Choline metabolism in cancer_Homo sapiens_hsa052310.86540049
63Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.85952651
64Oxytocin signaling pathway_Homo sapiens_hsa049210.83753892
65beta-Alanine metabolism_Homo sapiens_hsa004100.83346268
66Osteoclast differentiation_Homo sapiens_hsa043800.82690797
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.81769011
68Pentose and glucuronate interconversions_Homo sapiens_hsa000400.81462135
69Phenylalanine metabolism_Homo sapiens_hsa003600.79567616
70Dopaminergic synapse_Homo sapiens_hsa047280.79159908
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78428689
72Biosynthesis of amino acids_Homo sapiens_hsa012300.77824113
73Amoebiasis_Homo sapiens_hsa051460.76571508
74Peroxisome_Homo sapiens_hsa041460.76247332
75Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.75709540
76ECM-receptor interaction_Homo sapiens_hsa045120.75364855
77Non-small cell lung cancer_Homo sapiens_hsa052230.74709690
78Melanogenesis_Homo sapiens_hsa049160.74409126
79Calcium signaling pathway_Homo sapiens_hsa040200.73990702
80Inositol phosphate metabolism_Homo sapiens_hsa005620.73958517
81Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.73819088
82Glucagon signaling pathway_Homo sapiens_hsa049220.72930752
83Rap1 signaling pathway_Homo sapiens_hsa040150.72282878
84B cell receptor signaling pathway_Homo sapiens_hsa046620.71726195
85Acute myeloid leukemia_Homo sapiens_hsa052210.71331033
86mTOR signaling pathway_Homo sapiens_hsa041500.71007896
87MAPK signaling pathway_Homo sapiens_hsa040100.70953748
88ErbB signaling pathway_Homo sapiens_hsa040120.70769343
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.70626151
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69766927
91GnRH signaling pathway_Homo sapiens_hsa049120.69405685
92Pertussis_Homo sapiens_hsa051330.68284776
93Lysosome_Homo sapiens_hsa041420.68144684
94Caffeine metabolism_Homo sapiens_hsa002320.67805231
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67425057
96Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.66804264
97Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.66406029
98AMPK signaling pathway_Homo sapiens_hsa041520.66030314
99ABC transporters_Homo sapiens_hsa020100.64268604
100Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.64184902
101Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.64095059
102Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63614749
103cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63556758
104Insulin resistance_Homo sapiens_hsa049310.63156309
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62842970
106Chronic myeloid leukemia_Homo sapiens_hsa052200.62607256
107Fat digestion and absorption_Homo sapiens_hsa049750.62556658
108Vascular smooth muscle contraction_Homo sapiens_hsa042700.61807241
109Cocaine addiction_Homo sapiens_hsa050300.61388859
110Pancreatic secretion_Homo sapiens_hsa049720.60905387
111T cell receptor signaling pathway_Homo sapiens_hsa046600.60716619
112Fatty acid biosynthesis_Homo sapiens_hsa000610.60244458
113Fructose and mannose metabolism_Homo sapiens_hsa000510.59736631
114Insulin signaling pathway_Homo sapiens_hsa049100.59584946
115Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59249285
116Malaria_Homo sapiens_hsa051440.59045266
117Notch signaling pathway_Homo sapiens_hsa043300.58635341
118cAMP signaling pathway_Homo sapiens_hsa040240.58561037
119Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58441891
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.58145053
121Histidine metabolism_Homo sapiens_hsa003400.58033128
122Endometrial cancer_Homo sapiens_hsa052130.57724957
123Ras signaling pathway_Homo sapiens_hsa040140.56990338
124Galactose metabolism_Homo sapiens_hsa000520.56705355
125Thyroid hormone synthesis_Homo sapiens_hsa049180.56689284
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.55480209
127Platelet activation_Homo sapiens_hsa046110.54900944
128Chemical carcinogenesis_Homo sapiens_hsa052040.54792561
129Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.54296392
130Glycerolipid metabolism_Homo sapiens_hsa005610.54268048
131Sulfur relay system_Homo sapiens_hsa041220.53854793
132Cyanoamino acid metabolism_Homo sapiens_hsa004600.53657750
133Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.52169614
134Gap junction_Homo sapiens_hsa045400.51844231
135Proteoglycans in cancer_Homo sapiens_hsa052050.51839327
136Hepatitis C_Homo sapiens_hsa051600.50758628
137Circadian rhythm_Homo sapiens_hsa047100.49938265
138Mineral absorption_Homo sapiens_hsa049780.49380182
139Taste transduction_Homo sapiens_hsa047420.49051637
140Glioma_Homo sapiens_hsa052140.48986187
141Staphylococcus aureus infection_Homo sapiens_hsa051500.48410818
142Tyrosine metabolism_Homo sapiens_hsa003500.48203074
143Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.48067363
144Estrogen signaling pathway_Homo sapiens_hsa049150.47834932
145Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45847245
146Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44427221
147Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43327700
148Prion diseases_Homo sapiens_hsa050200.42457594
149Long-term depression_Homo sapiens_hsa047300.42036317
150Central carbon metabolism in cancer_Homo sapiens_hsa052300.41270790
151Cysteine and methionine metabolism_Homo sapiens_hsa002700.40848571

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