ST6GALNAC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Glycosylation of proteins affects cell-cell interaction, interactions with the matrix, and the functions of intracellular molecules. ST6GALNAC1 transfers a sialic acid, N-acetylneuraminic acid (NeuAc), in an alpha-2,6 linkage to O-linked GalNAc residues. The cancer-associated sialyl-Tn (sTn) antigen is formed by ST6GALNAC1-catalyzed sialylation of GalNAc residues on mucins (Ikehara et al., 1999 [PubMed 10536037]; Sewell et al., 2006 [PubMed 16319059]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)8.70716850
2cilium or flagellum-dependent cell motility (GO:0001539)6.95607183
3angiotensin maturation (GO:0002003)5.99456086
4motile cilium assembly (GO:0044458)5.93470904
5vitamin transmembrane transport (GO:0035461)5.86881683
6ethanol oxidation (GO:0006069)5.84923960
7ethanol metabolic process (GO:0006067)5.75956685
8primary alcohol catabolic process (GO:0034310)5.66248368
9regulation of guanylate cyclase activity (GO:0031282)5.59816742
10cilium movement (GO:0003341)5.55944613
11intestinal absorption (GO:0050892)5.49375260
12mesenchymal cell differentiation involved in kidney development (GO:0072161)5.46987621
13mesenchymal cell differentiation involved in renal system development (GO:2001012)5.46987621
14regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.41210012
15diterpenoid biosynthetic process (GO:0016102)5.33355146
16O-glycan processing (GO:0016266)5.08410113
17positive regulation of respiratory burst (GO:0060267)4.89604778
18calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.77527845
19epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.74676472
20NADH metabolic process (GO:0006734)4.71243596
21presynaptic membrane assembly (GO:0097105)4.61657541
22epithelial cilium movement (GO:0003351)4.59829026
23epoxygenase P450 pathway (GO:0019373)4.57888512
24presynaptic membrane organization (GO:0097090)4.51999370
25daunorubicin metabolic process (GO:0044597)4.47400490
26polyketide metabolic process (GO:0030638)4.47400490
27doxorubicin metabolic process (GO:0044598)4.47400490
28antibacterial humoral response (GO:0019731)4.44974031
29cerebral cortex radially oriented cell migration (GO:0021799)4.40217122
30sperm capacitation (GO:0048240)4.32158096
31flavonoid metabolic process (GO:0009812)4.31354262
32maintenance of gastrointestinal epithelium (GO:0030277)4.29477759
33antimicrobial humoral response (GO:0019730)4.24812263
34positive regulation of pseudopodium assembly (GO:0031274)4.17379238
35superoxide anion generation (GO:0042554)4.15757725
36transcytosis (GO:0045056)4.11306936
37positive regulation of guanylate cyclase activity (GO:0031284)4.07592177
38regulation of cellular extravasation (GO:0002691)4.00720212
39cellular glucuronidation (GO:0052695)3.97960684
40uronic acid metabolic process (GO:0006063)3.91232626
41glucuronate metabolic process (GO:0019585)3.91232626
42one-carbon compound transport (GO:0019755)3.87242650
43glomerular filtration (GO:0003094)3.81855936
44regulation of systemic arterial blood pressure by hormone (GO:0001990)3.81658080
45regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.81658080
46endocrine process (GO:0050886)3.81658080
47exogenous drug catabolic process (GO:0042738)3.79902741
48limb bud formation (GO:0060174)3.78894818
49receptor guanylyl cyclase signaling pathway (GO:0007168)3.71168519
50regulation of pseudopodium assembly (GO:0031272)3.70472325
51primary alcohol metabolic process (GO:0034308)3.67518580
52axoneme assembly (GO:0035082)3.63173329
53terpenoid biosynthetic process (GO:0016114)3.60601939
54drug metabolic process (GO:0017144)3.60176568
55phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.59092077
56excretion (GO:0007588)3.56510072
57regulation of vitamin metabolic process (GO:0030656)3.55926851
58sodium ion homeostasis (GO:0055078)3.55812295
59lipoprotein transport (GO:0042953)3.53012586
60digestion (GO:0007586)3.51475171
61fat-soluble vitamin biosynthetic process (GO:0042362)3.50856741
62bile acid and bile salt transport (GO:0015721)3.48984908
63regulation of respiratory burst (GO:0060263)3.48350464
64renal filtration (GO:0097205)3.46603314
65drug catabolic process (GO:0042737)3.44210227
66desmosome organization (GO:0002934)3.43306196
67retinol metabolic process (GO:0042572)3.39430582
68nucleoside diphosphate biosynthetic process (GO:0009133)3.37004106
69multicellular organismal water homeostasis (GO:0050891)3.36816253
70fructose metabolic process (GO:0006000)3.36335154
71glutathione biosynthetic process (GO:0006750)3.34883588
72regulation of systemic arterial blood pressure (GO:0003073)3.32688840
73protein O-linked glycosylation (GO:0006493)3.30520656
74glycosylceramide metabolic process (GO:0006677)3.29092214
75regulation of cGMP biosynthetic process (GO:0030826)3.27523493
76bundle of His cell to Purkinje myocyte communication (GO:0086069)3.26427819
77digestive system process (GO:0022600)3.26105282
78hormone catabolic process (GO:0042447)3.25143461
79renal system process involved in regulation of blood volume (GO:0001977)3.23897789
80postsynaptic membrane organization (GO:0001941)3.23076753
81GDP-mannose metabolic process (GO:0019673)3.22378596
82nonribosomal peptide biosynthetic process (GO:0019184)3.14976537
83energy homeostasis (GO:0097009)3.14944923
84sphingomyelin metabolic process (GO:0006684)3.14878088
85antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.12992146
86regulation of timing of cell differentiation (GO:0048505)3.12739229
87sulfur compound transport (GO:0072348)3.11469101
88retinoic acid metabolic process (GO:0042573)3.09558220
89glutathione derivative metabolic process (GO:1901685)3.08976384
90glutathione derivative biosynthetic process (GO:1901687)3.08976384
91glycosphingolipid catabolic process (GO:0046479)3.07597814
92very-low-density lipoprotein particle assembly (GO:0034379)3.07585819
93ionotropic glutamate receptor signaling pathway (GO:0035235)3.07316050
94negative regulation of homotypic cell-cell adhesion (GO:0034111)3.06377676
95epithelial structure maintenance (GO:0010669)3.03401080
96melanin biosynthetic process (GO:0042438)3.03196987
97regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.02206724
98intestinal epithelial cell development (GO:0060576)3.01807771
99glycolipid catabolic process (GO:0019377)2.98679661
100antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.98518751
101cell differentiation involved in metanephros development (GO:0072202)2.97863228
102positive regulation of glycoprotein metabolic process (GO:1903020)2.95509239
103regulation of bile acid biosynthetic process (GO:0070857)2.95057640
104inner ear receptor stereocilium organization (GO:0060122)2.94796234
105glutathione metabolic process (GO:0006749)2.94209682
106vitamin transport (GO:0051180)2.93251991
107urea cycle (GO:0000050)2.92842407
108neuron cell-cell adhesion (GO:0007158)2.92747926
109progesterone metabolic process (GO:0042448)2.92015230
110positive regulation of glycoprotein biosynthetic process (GO:0010560)2.91969414
111short-chain fatty acid metabolic process (GO:0046459)2.90289416
112detection of molecule of bacterial origin (GO:0032490)2.89904598
113opioid receptor signaling pathway (GO:0038003)2.86204745
114polyol transport (GO:0015791)2.85808439
115vocalization behavior (GO:0071625)2.84766229
116long-chain fatty acid biosynthetic process (GO:0042759)2.84673226
117renal absorption (GO:0070293)2.84026180
118negative regulation of keratinocyte proliferation (GO:0010839)2.82856644
119mesenchymal cell differentiation (GO:0048762)2.82267293
120keratinocyte development (GO:0003334)2.81384868
121cellular response to reactive nitrogen species (GO:1902170)2.80780998
122neurotransmitter biosynthetic process (GO:0042136)2.78958915
123negative regulation of synaptic transmission, GABAergic (GO:0032229)2.78903825
124phenol-containing compound catabolic process (GO:0019336)2.78657808
125glutamate receptor signaling pathway (GO:0007215)2.78079904
126behavioral response to nicotine (GO:0035095)2.76928280
127positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.75811798
128T-helper cell differentiation (GO:0042093)2.75795404
129CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.75795404
130cell proliferation in forebrain (GO:0021846)2.75415124
131regulation of synapse maturation (GO:0090128)2.74429480
132righting reflex (GO:0060013)2.72438814
133auditory receptor cell stereocilium organization (GO:0060088)2.71150343
134regulation of heat generation (GO:0031650)2.68953326
135aminoglycoside antibiotic metabolic process (GO:0030647)2.68631024
136G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.68411497
137cranial nerve morphogenesis (GO:0021602)2.67825482
138cell differentiation involved in kidney development (GO:0061005)2.67148591
139forebrain neuron differentiation (GO:0021879)2.65887884
140cerebral cortex cell migration (GO:0021795)2.65621687
141serotonin receptor signaling pathway (GO:0007210)2.62250877
142regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.61817379
143regulation of platelet aggregation (GO:0090330)2.61060381
144microtubule depolymerization (GO:0007019)2.59424332
145regulation of development, heterochronic (GO:0040034)2.57759462
146mitochondrial calcium ion homeostasis (GO:0051560)2.56194423
147sulfate transport (GO:0008272)2.54691527
148central nervous system projection neuron axonogenesis (GO:0021952)2.54621371
149developmental pigmentation (GO:0048066)2.52238809
150positive regulation of synapse assembly (GO:0051965)2.51977661
151kidney morphogenesis (GO:0060993)2.51707430
152positive regulation of uterine smooth muscle contraction (GO:0070474)2.50235044
153calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.49903621
154sulfate transmembrane transport (GO:1902358)2.47933341
155positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.47810688
156nucleotide transmembrane transport (GO:1901679)2.46196630
157regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.44834872
158mature B cell differentiation (GO:0002335)2.40830457
159positive regulation of action potential (GO:0045760)2.40686892
160CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.37853417
161synaptic transmission, glutamatergic (GO:0035249)2.37555971
162regulation of pigment cell differentiation (GO:0050932)2.36937736
163alpha-beta T cell differentiation involved in immune response (GO:0002293)2.36741544
164alpha-beta T cell activation involved in immune response (GO:0002287)2.36741544
165T cell differentiation involved in immune response (GO:0002292)2.36741544
166cranial nerve structural organization (GO:0021604)2.36146900
167adenosine metabolic process (GO:0046085)2.35260447
168behavioral response to ethanol (GO:0048149)2.35043996
169cellular anion homeostasis (GO:0030002)2.34809352
170positive regulation of icosanoid secretion (GO:0032305)2.34588455
171T-helper 1 type immune response (GO:0042088)2.32766704
172extracellular negative regulation of signal transduction (GO:1900116)2.31156200
173extracellular regulation of signal transduction (GO:1900115)2.31156200
174mature B cell differentiation involved in immune response (GO:0002313)2.29710447
175positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.28651469
176neuron remodeling (GO:0016322)2.28569511
177regulation of inositol phosphate biosynthetic process (GO:0010919)2.27243837
178negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.26193336
179positive regulation of heat generation (GO:0031652)2.24864483
180female gonad development (GO:0008585)2.24129307
181pyrimidine-containing compound transmembrane transport (GO:0072531)2.23257572
182prostate gland growth (GO:0060736)2.23028045
183positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.22725934
184regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.19695696
185mesonephros development (GO:0001823)2.19028140
186neuronal ion channel clustering (GO:0045161)2.18983481
187positive regulation of meiosis (GO:0045836)2.18478282
188detection of external biotic stimulus (GO:0098581)2.18371799
189cornea development in camera-type eye (GO:0061303)2.18164024
190positive regulation of protein homodimerization activity (GO:0090073)2.18007898
191L-amino acid import (GO:0043092)2.17467450
192eosinophil chemotaxis (GO:0048245)2.16984522
193regulation of synapse assembly (GO:0051963)2.16680244
194superoxide metabolic process (GO:0006801)2.16566276
195organ growth (GO:0035265)2.16545292
196cAMP catabolic process (GO:0006198)2.16401063
197positive regulation of cellular amide metabolic process (GO:0034250)2.15965214

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CDX2_20551321_ChIP-Seq_CACO-2_Human5.29378656
2EZH2_22144423_ChIP-Seq_EOC_Human3.73141798
3SOX2_27498859_Chip-Seq_STOMACH_Mouse3.53719202
4GBX2_23144817_ChIP-Seq_PC3_Human3.49776717
5FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human3.09642917
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.91046140
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.87927593
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.84488766
9* GATA4_25053715_ChIP-Seq_YYC3_Human2.84215367
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.64397012
11* GATA6_25053715_ChIP-Seq_YYC3_Human2.60052246
12SOX2_20726797_ChIP-Seq_SW620_Human2.58770490
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.49157442
14TP63_17297297_ChIP-ChIP_HaCaT_Human2.45341711
15* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.39681526
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.34503022
17BMI1_23680149_ChIP-Seq_NPCS_Mouse2.31730198
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.30266186
19CBX2_27304074_Chip-Seq_ESCs_Mouse2.28192264
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.28086817
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.23428209
22TAF15_26573619_Chip-Seq_HEK293_Human2.23400411
23FOXO3_23340844_ChIP-Seq_DLD1_Human2.22144809
24SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.21587746
25HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.21262136
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.19747864
27SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.18586940
28GATA1_19941826_ChIP-Seq_K562_Human2.18008950
29SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.16596323
30PCGF2_27294783_Chip-Seq_ESCs_Mouse2.15961431
31RXR_22158963_ChIP-Seq_LIVER_Mouse2.14109507
32ESR1_21235772_ChIP-Seq_MCF-7_Human2.13292134
33VDR_22108803_ChIP-Seq_LS180_Human2.11347721
34IGF1R_20145208_ChIP-Seq_DFB_Human2.11239136
35TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.10744016
36SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.07717317
37* AR_21915096_ChIP-Seq_LNCaP-1F5_Human2.04311156
38PPARA_22158963_ChIP-Seq_LIVER_Mouse2.01531105
39AR_21572438_ChIP-Seq_LNCaP_Human1.98818355
40* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.97569950
41JARID2_20075857_ChIP-Seq_MESCs_Mouse1.95642266
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.95135500
43* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.93396705
44SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.90732958
45ESR2_21235772_ChIP-Seq_MCF-7_Human1.89335026
46* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.89058178
47LXR_22158963_ChIP-Seq_LIVER_Mouse1.88855618
48RNF2_18974828_ChIP-Seq_MESCs_Mouse1.88503522
49EZH2_18974828_ChIP-Seq_MESCs_Mouse1.88503522
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.88461180
51CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.88085040
52RUNX1_27514584_Chip-Seq_MCF-7_Human1.86926977
53P300_19829295_ChIP-Seq_ESCs_Human1.85456169
54SUZ12_27294783_Chip-Seq_NPCs_Mouse1.85014108
55* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.84048275
56ZNF263_19887448_ChIP-Seq_K562_Human1.80844190
57GATA2_19941826_ChIP-Seq_K562_Human1.80343847
58IRF8_22096565_ChIP-ChIP_GC-B_Human1.80142245
59KLF5_25053715_ChIP-Seq_YYC3_Human1.78418095
60PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.76914611
61* EZH2_27294783_Chip-Seq_ESCs_Mouse1.75127256
62PCGF2_27294783_Chip-Seq_NPCs_Mouse1.74696731
63TRIM28_21343339_ChIP-Seq_HEK293_Human1.72817302
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.72798865
65NANOG_18555785_Chip-Seq_ESCs_Mouse1.72655270
66RNF2_27304074_Chip-Seq_ESCs_Mouse1.70815944
67RACK7_27058665_Chip-Seq_MCF-7_Human1.70517478
68EGR1_23403033_ChIP-Seq_LIVER_Mouse1.69769387
69* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.69193013
70EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.68967502
71TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.68844353
72PIAS1_25552417_ChIP-Seq_VCAP_Human1.67646005
73NFE2_27457419_Chip-Seq_LIVER_Mouse1.66779509
74TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.66441300
75E2F1_18555785_Chip-Seq_ESCs_Mouse1.66220414
76PPAR_26484153_Chip-Seq_NCI-H1993_Human1.65464962
77P53_22387025_ChIP-Seq_ESCs_Mouse1.64664902
78ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.64156315
79* FOXA1_25552417_ChIP-Seq_VCAP_Human1.63939695
80SUZ12_27294783_Chip-Seq_ESCs_Mouse1.63145045
81CDX2_19796622_ChIP-Seq_MESCs_Mouse1.62323022
82PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.59664787
83SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58736085
84SMAD3_21741376_ChIP-Seq_EPCs_Human1.58716936
85SUZ12_18555785_Chip-Seq_ESCs_Mouse1.58521358
86* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.57445482
87SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.57310819
88SMAD4_21799915_ChIP-Seq_A2780_Human1.56570835
89BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.56158176
90GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.55647208
91RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.55534477
92RNF2_27304074_Chip-Seq_NSC_Mouse1.54757783
93STAT3_18555785_Chip-Seq_ESCs_Mouse1.54454830
94TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53979254
95EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.51677955
96CTBP2_25329375_ChIP-Seq_LNCAP_Human1.51206003
97LXR_22292898_ChIP-Seq_THP-1_Human1.50679683
98CMYC_18555785_Chip-Seq_ESCs_Mouse1.50618021
99CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.50188170
100SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.49451882
101NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.49317499
102MTF2_20144788_ChIP-Seq_MESCs_Mouse1.48649434
103EZH2_27294783_Chip-Seq_NPCs_Mouse1.48612002
104STAT1_20625510_ChIP-Seq_HELA_Human1.46992182
105* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.46477124
106TP53_18474530_ChIP-ChIP_U2OS_Human1.45733807
107CLOCK_20551151_ChIP-Seq_293T_Human1.45439853
108P63_26484246_Chip-Seq_KERATINOCYTES_Human1.44520417
109P300_18555785_Chip-Seq_ESCs_Mouse1.41735387
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41159400
111POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.41159400
112NMYC_18555785_Chip-Seq_ESCs_Mouse1.40273794
113FUS_26573619_Chip-Seq_HEK293_Human1.39145648
114ER_23166858_ChIP-Seq_MCF-7_Human1.39023559
115RUNX1_27457419_Chip-Seq_LIVER_Mouse1.38876932
116POU5F1_16153702_ChIP-ChIP_HESCs_Human1.38322069
117CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36813730
118SOX2_18555785_Chip-Seq_ESCs_Mouse1.36746389
119BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.34186399
120FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.33792093
121OCT4_18555785_Chip-Seq_ESCs_Mouse1.33702420
122AR_25329375_ChIP-Seq_VCAP_Human1.33643490
123TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31078885
124IKZF1_21737484_ChIP-ChIP_HCT116_Human1.30272040
125PU1_27457419_Chip-Seq_LIVER_Mouse1.29389618
126BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.28892306
127* GATA3_24758297_ChIP-Seq_MCF-7_Human1.28843390
128CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27906737
129TCF4_18268006_ChIP-ChIP_LS174T_Human1.27698227
130DROSHA_22980978_ChIP-Seq_HELA_Human1.27429936
131CEBPB_22108803_ChIP-Seq_LS180_Human1.24974861
132SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24628551
133PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.24426571
134UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24164333
135ZFX_18555785_Chip-Seq_ESCs_Mouse1.23101147
136REST_21632747_ChIP-Seq_MESCs_Mouse1.22699061
137AR_21909140_ChIP-Seq_LNCAP_Human1.22372257
138AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21722412
139OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21495477
140VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.20591880
141CDX2_22108803_ChIP-Seq_LS180_Human1.19391890
142KLF4_18555785_Chip-Seq_ESCs_Mouse1.19349639
143ESRRB_18555785_Chip-Seq_ESCs_Mouse1.18902785
144MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17983550
145ARNT_22903824_ChIP-Seq_MCF-7_Human1.16771324
146ESR1_20079471_ChIP-ChIP_T-47D_Human1.16216433
147THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.15656148
148CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.15411215
149ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14693275
150RAD21_21589869_ChIP-Seq_MESCs_Mouse1.13944518
151STAT3_23295773_ChIP-Seq_U87_Human1.13732851
152CTCF_18555785_Chip-Seq_ESCs_Mouse1.13222388
153TAL1_26923725_Chip-Seq_HPCs_Mouse1.12322737
154SMAD1_18555785_Chip-Seq_ESCs_Mouse1.12177000
155* TP63_22573176_ChIP-Seq_HFKS_Human1.11850930
156* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.11683792
157KDM2B_26808549_Chip-Seq_REH_Human1.11335609
158SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.10888378
159RUNX2_22187159_ChIP-Seq_PCA_Human1.10404965
160AHR_22903824_ChIP-Seq_MCF-7_Human1.10183389
161NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09365984
162* HNF4A_19822575_ChIP-Seq_HepG2_Human1.08828352
163CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07557371
164BCOR_27268052_Chip-Seq_Bcells_Human1.07465741
165TCF4_23295773_ChIP-Seq_U87_Human1.07015118
166CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.05230194
167SA1_27219007_Chip-Seq_Bcells_Human1.04977818
168CREB1_26743006_Chip-Seq_LNCaP_Human1.04420234
169SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.03863289
170CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02661641
171* FOXA2_19822575_ChIP-Seq_HepG2_Human1.02178367
172HNFA_21074721_ChIP-Seq_CACO-2_Human1.02068584
173GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01069083
174RARG_19884340_ChIP-ChIP_MEFs_Mouse1.00399065
175* SMC4_20622854_ChIP-Seq_HELA_Human0.99949114
176GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.96901533
177* BCL6_27268052_Chip-Seq_Bcells_Human0.96894359
178MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.96551993
179* NCOR1_26117541_ChIP-Seq_K562_Human0.95704485
180PHF8_20622854_ChIP-Seq_HELA_Human0.95503547
181GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.95120573
182TP63_23658742_ChIP-Seq_EP156T_Human0.94196117
183RBPJ_21746931_ChIP-Seq_IB4_Human0.94049830
184CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.93932424
185ETV1_20927104_ChIP-Seq_GIST48_Human0.93915938
186P300_27268052_Chip-Seq_Bcells_Human0.92586305
187CTCF_27219007_Chip-Seq_Bcells_Human0.92232353
188PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.91999726
189E2F1_20622854_ChIP-Seq_HELA_Human0.90100693
190ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88672492
191CTCF_20526341_ChIP-Seq_ESCs_Human0.87249993
192CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.86919703
193GATA6_21074721_ChIP-Seq_CACO-2_Human0.86380556
194SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84637100
195PHF8_20622853_ChIP-Seq_HELA_Human0.83030898
196* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.82351776
197NANOG_20526341_ChIP-Seq_ESCs_Human0.82099397
198SPI1_23127762_ChIP-Seq_K562_Human0.80740089

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.01959473
2MP0005360_urolithiasis4.57706782
3MP0003136_yellow_coat_color4.27276739
4MP0002139_abnormal_hepatobiliary_system4.11959929
5MP0005085_abnormal_gallbladder_physiolo3.65082213
6MP0002102_abnormal_ear_morphology3.58299687
7MP0001188_hyperpigmentation3.38679802
8MP0000566_synostosis3.32933218
9MP0006292_abnormal_olfactory_placode3.25837247
10MP0001666_abnormal_nutrient_absorption3.24618745
11MP0004264_abnormal_extraembryonic_tissu3.18454887
12MP0010155_abnormal_intestine_physiology3.09793144
13MP0005377_hearing/vestibular/ear_phenot2.93893953
14MP0003878_abnormal_ear_physiology2.93893953
15MP0005171_absent_coat_pigmentation2.92873987
16MP0008875_abnormal_xenobiotic_pharmacok2.81796861
17MP0005365_abnormal_bile_salt2.77711209
18MP0003880_abnormal_central_pattern2.74537018
19MP0003866_abnormal_defecation2.73631904
20MP0005408_hypopigmentation2.45474102
21MP0003787_abnormal_imprinting2.29409842
22MP0002277_abnormal_respiratory_mucosa2.27415506
23MP0005645_abnormal_hypothalamus_physiol2.24239291
24MP0003183_abnormal_peptide_metabolism2.22005819
25MP0010352_gastrointestinal_tract_polyps2.21115135
26MP0003806_abnormal_nucleotide_metabolis2.20262462
27MP0001765_abnormal_ion_homeostasis2.14848136
28MP0004381_abnormal_hair_follicle2.11032374
29MP0002735_abnormal_chemical_nociception2.09665396
30MP0004742_abnormal_vestibular_system1.98513666
31MP0002938_white_spotting1.94439664
32MP0000490_abnormal_crypts_of1.93804976
33MP0000015_abnormal_ear_pigmentation1.91243631
34MP0001501_abnormal_sleep_pattern1.89265570
35MP0005636_abnormal_mineral_homeostasis1.87332848
36MP0001486_abnormal_startle_reflex1.86818861
37MP0001663_abnormal_digestive_system1.86097225
38MP0000477_abnormal_intestine_morphology1.82383561
39MP0009745_abnormal_behavioral_response1.81618786
40MP0010386_abnormal_urinary_bladder1.78805381
41MP0002876_abnormal_thyroid_physiology1.78690832
42MP0006276_abnormal_autonomic_nervous1.77370134
43MP0001873_stomach_inflammation1.75037838
44MP0002572_abnormal_emotion/affect_behav1.72184336
45MP0009643_abnormal_urine_homeostasis1.67224475
46MP0003724_increased_susceptibility_to1.63160167
47MP0001485_abnormal_pinna_reflex1.63006336
48MP0000465_gastrointestinal_hemorrhage1.58477741
49MP0008004_abnormal_stomach_pH1.56740965
50MP0005646_abnormal_pituitary_gland1.52214305
51MP0005166_decreased_susceptibility_to1.50806214
52MP0002063_abnormal_learning/memory/cond1.46027152
53MP0003941_abnormal_skin_development1.43871019
54MP0001346_abnormal_lacrimal_gland1.41629926
55MP0002736_abnormal_nociception_after1.40887486
56MP0001968_abnormal_touch/_nociception1.40486843
57MP0002638_abnormal_pupillary_reflex1.40264487
58MP0005409_darkened_coat_color1.38859939
59MP0001905_abnormal_dopamine_level1.38766331
60MP0000026_abnormal_inner_ear1.38317105
61MP0002249_abnormal_larynx_morphology1.34108854
62MP0002272_abnormal_nervous_system1.33139502
63MP0000569_abnormal_digit_pigmentation1.31794743
64MP0009046_muscle_twitch1.30101653
65MP0000372_irregular_coat_pigmentation1.28754024
66MP0005165_increased_susceptibility_to1.28559843
67MP0002136_abnormal_kidney_physiology1.26366329
68MP0004782_abnormal_surfactant_physiolog1.26358147
69MP0001440_abnormal_grooming_behavior1.24806583
70MP0001881_abnormal_mammary_gland1.24705525
71MP0004142_abnormal_muscle_tone1.24323715
72MP0003938_abnormal_ear_development1.24061726
73MP0002067_abnormal_sensory_capabilities1.23708200
74MP0005083_abnormal_biliary_tract1.23012032
75MP0010678_abnormal_skin_adnexa1.22707344
76MP0002098_abnormal_vibrissa_morphology1.22468577
77MP0004859_abnormal_synaptic_plasticity1.22376594
78MP0003868_abnormal_feces_composition1.21684708
79MP0009840_abnormal_foam_cell1.21076170
80MP0002557_abnormal_social/conspecific_i1.20646840
81MP0003635_abnormal_synaptic_transmissio1.19992934
82MP0003879_abnormal_hair_cell1.18164837
83MP0000681_abnormal_thyroid_gland1.18009190
84MP0001963_abnormal_hearing_physiology1.17248683
85MP0002064_seizures1.17216522
86MP0008995_early_reproductive_senescence1.16220906
87MP0003252_abnormal_bile_duct1.15075689
88MP0005332_abnormal_amino_acid1.13016774
89MP0002796_impaired_skin_barrier1.12442500
90MP0010329_abnormal_lipoprotein_level1.12130921
91MP0001764_abnormal_homeostasis1.10446205
92MP0005248_abnormal_Harderian_gland1.07029614
93MP0000778_abnormal_nervous_system1.06873788
94MP0009250_abnormal_appendicular_skeleto1.06555923
95MP0004858_abnormal_nervous_system1.05595716
96MP0002132_abnormal_respiratory_system1.05386634
97MP0005174_abnormal_tail_pigmentation1.04683449
98MP0000049_abnormal_middle_ear1.04664150
99MP0004134_abnormal_chest_morphology1.03711955
100MP0009697_abnormal_copulation1.02375158
101MP0002148_abnormal_hypersensitivity_rea1.01905574
102MP0001835_abnormal_antigen_presentation1.01227251
103MP0005167_abnormal_blood-brain_barrier1.00095443
104MP0002177_abnormal_outer_ear1.00084531
105MP0003303_peritoneal_inflammation0.98962197
106MP0000762_abnormal_tongue_morphology0.98683638
107MP0002822_catalepsy0.98141165
108MP0008260_abnormal_autophagy0.96379069
109MP0005551_abnormal_eye_electrophysiolog0.96117458
110MP0002166_altered_tumor_susceptibility0.94784553
111MP0009780_abnormal_chondrocyte_physiolo0.94208826
112MP0005257_abnormal_intraocular_pressure0.94039710
113MP0009379_abnormal_foot_pigmentation0.92070743
114MP0000678_abnormal_parathyroid_gland0.89899880
115MP0005451_abnormal_body_composition0.89287527
116MP0004043_abnormal_pH_regulation0.89001171
117MP0005319_abnormal_enzyme/_coenzyme0.88892864
118MP0005379_endocrine/exocrine_gland_phen0.88556237
119MP0009785_altered_susceptibility_to0.87793487
120MP0001664_abnormal_digestion0.87559706
121MP0001986_abnormal_taste_sensitivity0.86897775
122MP0003385_abnormal_body_wall0.86869714
123MP0003786_premature_aging0.86859986
124MP0000013_abnormal_adipose_tissue0.86199472
125MP0000609_abnormal_liver_physiology0.84300519
126MP0005670_abnormal_white_adipose0.83847005
127MP0001502_abnormal_circadian_rhythm0.83303621
128MP0003890_abnormal_embryonic-extraembry0.83260383
129MP0003011_delayed_dark_adaptation0.82769444
130MP0000462_abnormal_digestive_system0.82309617
131MP0002118_abnormal_lipid_homeostasis0.82166160
132MP0005310_abnormal_salivary_gland0.81240347
133MP0002009_preneoplasia0.81104399
134MP0002095_abnormal_skin_pigmentation0.80727143
135MP0001756_abnormal_urination0.80470722
136MP0004019_abnormal_vitamin_homeostasis0.79375995
137MP0000537_abnormal_urethra_morphology0.77896165
138MP0005423_abnormal_somatic_nervous0.77834089
139MP0001970_abnormal_pain_threshold0.77539456
140MP0001845_abnormal_inflammatory_respons0.77461402
141MP0004147_increased_porphyrin_level0.77121395
142MP0009764_decreased_sensitivity_to0.76201379
143MP0002184_abnormal_innervation0.75312235
144MP0002734_abnormal_mechanical_nocicepti0.74876572
145MP0005253_abnormal_eye_physiology0.73107676
146MP0000467_abnormal_esophagus_morphology0.73077955
147MP0003937_abnormal_limbs/digits/tail_de0.72500055
148MP0003656_abnormal_erythrocyte_physiolo0.71773219
149MP0006082_CNS_inflammation0.70816228
150MP0005075_abnormal_melanosome_morpholog0.70022912
151MP0004484_altered_response_of0.69176288
152MP0008872_abnormal_physiological_respon0.68632570
153MP0005381_digestive/alimentary_phenotyp0.68197505
154MP0005025_abnormal_response_to0.67940662
155MP0004947_skin_inflammation0.67749843
156MP0001529_abnormal_vocalization0.65894228
157MP0005501_abnormal_skin_physiology0.65328510
158MP0003453_abnormal_keratinocyte_physiol0.65111539
159MP0001790_abnormal_immune_system0.63425716
160MP0005387_immune_system_phenotype0.63425716
161MP0003718_maternal_effect0.63118424
162MP0002138_abnormal_hepatobiliary_system0.61173702
163MP0002877_abnormal_melanocyte_morpholog0.60959144
164MP0005058_abnormal_lysosome_morphology0.60938969
165MP0005584_abnormal_enzyme/coenzyme_acti0.60880421
166MP0003300_gastrointestinal_ulcer0.59652682
167MP0002896_abnormal_bone_mineralization0.59491020
168MP0002653_abnormal_ependyma_morphology0.59483811
169MP0000538_abnormal_urinary_bladder0.57553637
170MP0009333_abnormal_splenocyte_physiolog0.57522696
171MP0001849_ear_inflammation0.54657309

Predicted human phenotypes

RankGene SetZ-score
1Hyperactive renin-angiotensin system (HP:0000841)7.52585861
2Chronic bronchitis (HP:0004469)6.45202958
3Bronchiectasis (HP:0002110)5.45553235
4Nasal polyposis (HP:0100582)5.34362356
5Decreased circulating renin level (HP:0003351)5.26660409
6Abnormality of the nasal mucosa (HP:0000433)5.02897599
7Chromosomal breakage induced by crosslinking agents (HP:0003221)4.92056407
8Abnormality of glutamine family amino acid metabolism (HP:0010902)4.87556803
9Abnormality of renin-angiotensin system (HP:0000847)4.63802505
10Chromsome breakage (HP:0040012)4.38638834
11Malnutrition (HP:0004395)4.21929182
12Abnormality of chloride homeostasis (HP:0011422)3.74007491
13Hyperaldosteronism (HP:0000859)3.67633390
14Abnormal ciliary motility (HP:0012262)3.62549186
15Bronchitis (HP:0012387)3.61312501
16Flat acetabular roof (HP:0003180)3.59241660
17Focal motor seizures (HP:0011153)3.58066898
18Metabolic alkalosis (HP:0200114)3.57949729
19Ileus (HP:0002595)3.57122506
20Absent/shortened dynein arms (HP:0200106)3.53335601
21Dynein arm defect of respiratory motile cilia (HP:0012255)3.53335601
22Abnormality of monocarboxylic acid metabolism (HP:0010996)3.52404610
23Alkalosis (HP:0001948)3.44437852
24Asymmetry of the thorax (HP:0001555)3.39687133
25Septo-optic dysplasia (HP:0100842)3.29273019
26Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.26004203
27Recurrent sinusitis (HP:0011108)3.21534411
28Febrile seizures (HP:0002373)3.18521609
29Prostate neoplasm (HP:0100787)3.13635156
30Hyponatremia (HP:0002902)3.07439929
31Male infertility (HP:0003251)3.03938476
32Fat malabsorption (HP:0002630)3.02784271
33Abnormality of proline metabolism (HP:0010907)2.94241986
34Hydroxyprolinuria (HP:0003080)2.94241986
35Abnormal respiratory epithelium morphology (HP:0012253)2.92004856
36Abnormal respiratory motile cilium morphology (HP:0005938)2.92004856
37Fibular aplasia (HP:0002990)2.90894482
38Infertility (HP:0000789)2.84205607
39Recurrent corneal erosions (HP:0000495)2.82409408
40Chronic sinusitis (HP:0011109)2.81911569
41Abnormal respiratory motile cilium physiology (HP:0012261)2.81526439
42Stomach cancer (HP:0012126)2.81233460
43Abnormality of incisor morphology (HP:0011063)2.79941949
44Conical tooth (HP:0000698)2.79459912
45Increased IgM level (HP:0003496)2.79103639
46Hyperkalemia (HP:0002153)2.76539379
47Chronic otitis media (HP:0000389)2.75501817
48Abnormality of the vitamin B12 metabolism (HP:0004341)2.74135520
49Recurrent otitis media (HP:0000403)2.69511533
50Chronic diarrhea (HP:0002028)2.68086535
51Abdominal distention (HP:0003270)2.64596002
52Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.61618808
53Parakeratosis (HP:0001036)2.61553313
54Abnormality of DNA repair (HP:0003254)2.61226063
55Optic nerve hypoplasia (HP:0000609)2.61181017
56Abnormality of vitamin metabolism (HP:0100508)2.58135434
57Abnormality of vitamin B metabolism (HP:0004340)2.52135667
58Renal salt wasting (HP:0000127)2.50842121
59Aplasia cutis congenita (HP:0001057)2.49244082
60Hemorrhage of the eye (HP:0011885)2.49108578
61Anomalous pulmonary venous return (HP:0010772)2.48696664
62White forelock (HP:0002211)2.46370325
63Nephroblastoma (Wilms tumor) (HP:0002667)2.44440656
64Morphological abnormality of the middle ear (HP:0008609)2.43613560
65Atelectasis (HP:0100750)2.40297532
66Hypotension (HP:0002615)2.39255874
67Tubulointerstitial nephritis (HP:0001970)2.37811299
68Right ventricular cardiomyopathy (HP:0011663)2.36939062
69Systemic lupus erythematosus (HP:0002725)2.36240986
70Aplasia/Hypoplasia of the fovea (HP:0008060)2.35494270
71Hypoplasia of the fovea (HP:0007750)2.35494270
72Patchy hypopigmentation of hair (HP:0011365)2.35372114
73Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.34629184
74Ectropion (HP:0000656)2.33921992
75Erythroderma (HP:0001019)2.33172060
76Abnormality of small intestinal villus morphology (HP:0011472)2.31983905
77Villous atrophy (HP:0011473)2.31983905
78Fibular hypoplasia (HP:0003038)2.31339948
79Tented upper lip vermilion (HP:0010804)2.30375506
80Acanthocytosis (HP:0001927)2.30215480
81Congenital ichthyosiform erythroderma (HP:0007431)2.30045805
82Embryonal renal neoplasm (HP:0011794)2.29227425
83Congenital sensorineural hearing impairment (HP:0008527)2.28953224
84Nasolacrimal duct obstruction (HP:0000579)2.27911810
85Abnormality of sodium homeostasis (HP:0010931)2.24430797
86Popliteal pterygium (HP:0009756)2.23637656
87Intrahepatic cholestasis (HP:0001406)2.20465107
88Abnormality of the septum pellucidum (HP:0007375)2.18092015
89Protruding tongue (HP:0010808)2.16194635
90Absent septum pellucidum (HP:0001331)2.16049114
91Abnormality of the pulmonary veins (HP:0011718)2.14847580
92Unilateral renal agenesis (HP:0000122)2.14583000
93Ventricular fibrillation (HP:0001663)2.10182342
94Aplasia/Hypoplasia of the tibia (HP:0005772)2.09537829
95Amelogenesis imperfecta (HP:0000705)2.07593721
96Hypophosphatemic rickets (HP:0004912)2.06318508
97Hypokalemia (HP:0002900)2.05772739
98Abnormality of the lacrimal duct (HP:0011481)2.05014601
99Osteomalacia (HP:0002749)2.04141922
100Abnormality of the preputium (HP:0100587)2.01372176
101Absent eyebrow (HP:0002223)2.00667908
102Abnormality of potassium homeostasis (HP:0011042)2.00555349
103Clubbing of toes (HP:0100760)2.00355266
104Pili torti (HP:0003777)2.00178783
105Abnormality of the nasolacrimal system (HP:0000614)1.99808967
106Alveolar cell carcinoma (HP:0006519)1.99763018
107Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.99754769
108Decreased central vision (HP:0007663)1.99582603
109Overfolded helix (HP:0000396)1.99042983
110Conjugated hyperbilirubinemia (HP:0002908)1.98320967
111Widely patent fontanelles and sutures (HP:0004492)1.98271677
112Fair hair (HP:0002286)1.97712305
113Aplasia/Hypoplasia of the uvula (HP:0010293)1.97160161
114Fetal akinesia sequence (HP:0001989)1.96519146
115Flattened epiphyses (HP:0003071)1.94896157
116Abnormality of the renal collecting system (HP:0004742)1.94344370
117Aplastic anemia (HP:0001915)1.93436847
118Adrenal overactivity (HP:0002717)1.91989354
119Hypobetalipoproteinemia (HP:0003563)1.90163596
120Short tibia (HP:0005736)1.88624713
121Abnormality of the fovea (HP:0000493)1.87622526
122Renal dysplasia (HP:0000110)1.87367921
123Abnormality of renal resorption (HP:0011038)1.86235578
124Dehydration (HP:0001944)1.84476586
125Steatorrhea (HP:0002570)1.80595137
126Cheilitis (HP:0100825)1.80449198
127Recurrent cutaneous fungal infections (HP:0011370)1.79401496
128Chronic mucocutaneous candidiasis (HP:0002728)1.79401496
129Syncope (HP:0001279)1.78930333
130Abnormal hair whorl (HP:0010721)1.78712748
131Nonprogressive disorder (HP:0003680)1.78521242
132Duplicated collecting system (HP:0000081)1.77470303
133Hyperammonemia (HP:0001987)1.77193257
134Abnormality of the fibula (HP:0002991)1.76159591
135Keratitis (HP:0000491)1.75793021
136Attenuation of retinal blood vessels (HP:0007843)1.75186636
137Occipital encephalocele (HP:0002085)1.74665564
138Aplasia involving bones of the upper limbs (HP:0009823)1.74307760
139Aplasia of the phalanges of the hand (HP:0009802)1.74307760
140Aplasia involving bones of the extremities (HP:0009825)1.74307760
141Meckel diverticulum (HP:0002245)1.73983969
142Epileptic encephalopathy (HP:0200134)1.72831013
143True hermaphroditism (HP:0010459)1.72550288
144Natal tooth (HP:0000695)1.71732273
145Xerostomia (HP:0000217)1.70783002
146Eczematoid dermatitis (HP:0000976)1.70718399
147Bifid uvula (HP:0000193)1.70267445
148Obstructive lung disease (HP:0006536)1.69059098
149Chronic obstructive pulmonary disease (HP:0006510)1.69059098
150Hyperphosphatemia (HP:0002905)1.68981406
151Aplasia/Hypoplasia of the fibula (HP:0006492)1.68870514
152Pigmentary retinal degeneration (HP:0001146)1.68789630
153Ocular albinism (HP:0001107)1.67976750
154Recurrent bronchitis (HP:0002837)1.66137812
155Abnormality of the renal medulla (HP:0100957)1.66116801
156Spinal cord compression (HP:0002176)1.65709430
157Focal segmental glomerulosclerosis (HP:0000097)1.65392502
158Broad-based gait (HP:0002136)1.64719863
159Increased purine levels (HP:0004368)1.63729651
160Hyperuricemia (HP:0002149)1.63729651
161Medulloblastoma (HP:0002885)1.63202536
162Abnormality of the dental pulp (HP:0006479)1.62664917
163Abnormality of the ileum (HP:0001549)1.62569746
164Glomerulonephritis (HP:0000099)1.62341002
165Thyroid-stimulating hormone excess (HP:0002925)1.61336711
166Generalized hypopigmentation of hair (HP:0011358)1.61161253
167Hyperparathyroidism (HP:0000843)1.60453333
168Vascular calcification (HP:0004934)1.60096939
169Rhinitis (HP:0012384)1.59460509
170Nephronophthisis (HP:0000090)1.59380227
171Abnormality of the distal phalanges of the toes (HP:0010182)1.57603649
172Abnormal hair laboratory examination (HP:0003328)1.56972337
173Glomerulosclerosis (HP:0000096)1.56870041
174Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.54950504
175Abnormal biliary tract morphology (HP:0012440)1.54354633
176Abnormal tarsal ossification (HP:0008369)1.52029644
177Visceral angiomatosis (HP:0100761)1.51415459
178Abnormality of carpal bone ossification (HP:0006257)1.50969530
179Metabolic acidosis (HP:0001942)1.50178798
180Posterior subcapsular cataract (HP:0007787)1.49074665
181Confusion (HP:0001289)1.47788095
182Polycythemia (HP:0001901)1.46998903
183Thin bony cortex (HP:0002753)1.46982353
184Gout (HP:0001997)1.46076308
185Renal tubular acidosis (HP:0001947)1.45737558
186Abnormality of urine glucose concentration (HP:0011016)1.45183052
187Glycosuria (HP:0003076)1.45183052

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.93661511
2ACVR1B4.93427912
3MAPK154.42878375
4RIPK13.14902736
5ERN12.79918973
6IRAK32.58760641
7BLK2.51041305
8LMTK22.46168937
9TNIK2.45614836
10MAP3K22.42795819
11TXK2.40068319
12INSRR2.36318032
13MKNK22.33910191
14MAP3K142.33910169
15NTRK32.29110155
16MAP2K72.11566752
17PRPF4B2.10100413
18MET2.05220088
19IRAK21.89387107
20PDK21.87592539
21ADRBK21.85555684
22PRKG21.83963204
23EPHA41.81834316
24SIK21.76796200
25SIK31.65930514
26NUAK11.64783682
27MAPK131.63930549
28PTK61.61820382
29EPHB11.60429892
30YES11.58604690
31TNK21.54666245
32STK241.53464831
33MAPKAPK31.52941773
34BMPR21.49376381
35IRAK41.46077792
36PKN11.44696437
37MAP3K101.40205900
38GRK11.37436886
39BCR1.36029905
40FER1.35311134
41SMG11.34533127
42NEK61.33424511
43MAP3K31.32590108
44FGFR41.31490273
45STK38L1.31328520
46ZAK1.29783032
47MST41.29214557
48RIPK41.26475017
49EEF2K1.26131267
50MUSK1.24037565
51TYK21.23445546
52MATK1.22676038
53GRK61.20738490
54AKT31.18339149
55TTK1.18067631
56EIF2AK21.16577580
57MST1R1.11673998
58MKNK11.09037409
59CAMK1D1.07448892
60CAMK1G1.06224091
61FGFR31.02895603
62NTRK20.99105962
63ERBB20.97937256
64CDK30.97395838
65PRKCE0.96883852
66MAP3K40.95301255
67PINK10.93289087
68BRAF0.92939825
69MYLK0.91032328
70PBK0.87806165
71IRAK10.87699063
72GRK70.87249434
73PLK20.87144483
74TRPM70.84041892
75CAMK10.82238555
76MAP3K10.77490854
77BMPR1B0.76983155
78EPHA30.75775039
79PDPK10.75160400
80CSK0.74639035
81TAOK10.74517401
82TESK10.73668953
83FES0.72758948
84SGK20.71573057
85NME10.70378347
86OXSR10.70114048
87PAK40.69573610
88PRKCQ0.68761038
89CAMK2B0.68619880
90EIF2AK10.68237208
91TEC0.67862323
92EPHB20.67569391
93PIK3CA0.66367731
94WNK40.66332233
95MAP2K20.65366687
96TRIB30.63954198
97IKBKE0.63946315
98FGR0.63717271
99CAMK2A0.62840738
100CDC42BPA0.61309685
101LRRK20.61259322
102PRKCI0.61208256
103DYRK1A0.61205103
104ZAP700.59506946
105CLK10.58633674
106EPHA20.57943639
107IKBKB0.57550401
108KSR20.57250510
109LYN0.57184105
110STK160.57129426
111PRKG10.56345052
112MARK10.56179437
113TAOK30.55391241
114SGK10.54299992
115MAPK120.52398523
116TBK10.52326202
117MAPK110.51762732
118ERBB30.51320834
119BRD40.51286409
120HCK0.50904901
121WNK10.48997956
122FRK0.46427277
123NLK0.45696898
124CAMKK20.44710047
125SGK2230.44686695
126SGK4940.44686695
127BRSK20.44271270
128PRKCG0.43867387
129MAP2K60.42637415
130PRKCA0.42208206
131MAP3K120.41786236
132JAK10.41752863
133PIK3CG0.40621091
134MAPK70.40410240
135PRKCH0.40396924
136BMX0.39501026
137CAMK2D0.39425825
138SYK0.39262987
139STK390.39132274
140PRKCD0.38858089
141LCK0.38755356
142PRKAA20.38158691
143CSNK1A1L0.38026036
144PRKACG0.37742547
145CHUK0.37710926
146ICK0.37646987
147ABL20.36806077
148ADRBK10.36689274
149PRKACA0.36558488
150PDK10.36002212
151SRPK10.34866043
152GRK50.34816913
153PTK2B0.33257162
154JAK20.30597263
155SRC0.30034972
156MAP3K70.29552192
157RET0.29068207
158TESK20.26672624
159FYN0.25916165
160WEE10.24402924
161DDR20.24289096
162MAP2K10.22422063
163MAP3K80.22085812
164CAMK2G0.21162188
165IGF1R0.20636277
166PTK20.20407228
167CDK60.20312928
168AKT20.18196823
169RPS6KB20.17763975
170CSNK1A10.17285128
171MAPKAPK20.13509328
172PRKCZ0.12934272

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004604.35398657
2Nicotine addiction_Homo sapiens_hsa050333.35858149
3Histidine metabolism_Homo sapiens_hsa003403.17733625
4Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.04539544
5Fat digestion and absorption_Homo sapiens_hsa049752.92491639
6Chemical carcinogenesis_Homo sapiens_hsa052042.82800528
7Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.75125319
8Caffeine metabolism_Homo sapiens_hsa002322.69371312
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.41902029
10Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.40766855
11Graft-versus-host disease_Homo sapiens_hsa053322.31142190
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.27660941
13Arginine biosynthesis_Homo sapiens_hsa002202.21478154
14Renin-angiotensin system_Homo sapiens_hsa046142.20452913
15Phenylalanine metabolism_Homo sapiens_hsa003602.14507318
16Tyrosine metabolism_Homo sapiens_hsa003502.07810382
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.05254483
18Pentose and glucuronate interconversions_Homo sapiens_hsa000401.99549668
19Fructose and mannose metabolism_Homo sapiens_hsa000511.98906843
20Taste transduction_Homo sapiens_hsa047421.97921030
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.97718666
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.96767108
23Starch and sucrose metabolism_Homo sapiens_hsa005001.89569445
24Nitrogen metabolism_Homo sapiens_hsa009101.89354268
25Autoimmune thyroid disease_Homo sapiens_hsa053201.84632521
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.84382222
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.79174782
28Fatty acid degradation_Homo sapiens_hsa000711.75222609
29Serotonergic synapse_Homo sapiens_hsa047261.70429275
30Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.69955614
31Fanconi anemia pathway_Homo sapiens_hsa034601.69847577
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.69612314
33Glutathione metabolism_Homo sapiens_hsa004801.67806988
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.66362447
35Morphine addiction_Homo sapiens_hsa050321.66279819
36Rheumatoid arthritis_Homo sapiens_hsa053231.65063935
37Glutamatergic synapse_Homo sapiens_hsa047241.60827943
38Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.57643971
39Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.55056742
40Fatty acid biosynthesis_Homo sapiens_hsa000611.54591651
41NF-kappa B signaling pathway_Homo sapiens_hsa040641.54032867
42Phototransduction_Homo sapiens_hsa047441.53619301
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.53567989
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.53508560
45Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.51159679
46Protein digestion and absorption_Homo sapiens_hsa049741.46055535
47Allograft rejection_Homo sapiens_hsa053301.45750779
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.42841688
49Carbohydrate digestion and absorption_Homo sapiens_hsa049731.42792217
50African trypanosomiasis_Homo sapiens_hsa051431.40797902
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.40180574
52Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.39602054
53SNARE interactions in vesicular transport_Homo sapiens_hsa041301.38605963
54Type I diabetes mellitus_Homo sapiens_hsa049401.37207171
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.36273534
56PPAR signaling pathway_Homo sapiens_hsa033201.35091793
57Arachidonic acid metabolism_Homo sapiens_hsa005901.33276476
58Primary immunodeficiency_Homo sapiens_hsa053401.33114350
59Sulfur metabolism_Homo sapiens_hsa009201.32594956
60Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.30228400
61Toll-like receptor signaling pathway_Homo sapiens_hsa046201.29377115
62Bile secretion_Homo sapiens_hsa049761.25534720
63Hematopoietic cell lineage_Homo sapiens_hsa046401.23183472
64Arginine and proline metabolism_Homo sapiens_hsa003301.23058977
65GABAergic synapse_Homo sapiens_hsa047271.19891619
66Galactose metabolism_Homo sapiens_hsa000521.19526428
67Axon guidance_Homo sapiens_hsa043601.18691055
68Calcium signaling pathway_Homo sapiens_hsa040201.17276566
692-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.16328755
70Mineral absorption_Homo sapiens_hsa049781.12454759
71Salivary secretion_Homo sapiens_hsa049701.09214612
72Maturity onset diabetes of the young_Homo sapiens_hsa049501.08798228
73Malaria_Homo sapiens_hsa051441.06414308
74Long-term depression_Homo sapiens_hsa047301.05242823
75Asthma_Homo sapiens_hsa053101.03965061
76Sphingolipid metabolism_Homo sapiens_hsa006001.03644716
77Circadian entrainment_Homo sapiens_hsa047131.02706672
78Vitamin digestion and absorption_Homo sapiens_hsa049771.01460403
79Ether lipid metabolism_Homo sapiens_hsa005651.01439503
80* Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.01035574
81Homologous recombination_Homo sapiens_hsa034400.99993535
82Pancreatic secretion_Homo sapiens_hsa049720.99565933
83NOD-like receptor signaling pathway_Homo sapiens_hsa046210.98632713
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.96148203
85Glycerolipid metabolism_Homo sapiens_hsa005610.93570778
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.92786492
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.91780649
88Measles_Homo sapiens_hsa051620.90823931
89Oxidative phosphorylation_Homo sapiens_hsa001900.90008954
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88271351
91Steroid biosynthesis_Homo sapiens_hsa001000.86814092
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.86018242
93Tryptophan metabolism_Homo sapiens_hsa003800.84381338
94Linoleic acid metabolism_Homo sapiens_hsa005910.79944325
95beta-Alanine metabolism_Homo sapiens_hsa004100.79093371
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78771768
97Other glycan degradation_Homo sapiens_hsa005110.78133984
98Tight junction_Homo sapiens_hsa045300.77938970
99Chemokine signaling pathway_Homo sapiens_hsa040620.74334305
100Melanoma_Homo sapiens_hsa052180.71681077
101TNF signaling pathway_Homo sapiens_hsa046680.71621501
102Leishmaniasis_Homo sapiens_hsa051400.71273696
103Ras signaling pathway_Homo sapiens_hsa040140.70072246
104Ovarian steroidogenesis_Homo sapiens_hsa049130.69820720
105Peroxisome_Homo sapiens_hsa041460.69465762
106Collecting duct acid secretion_Homo sapiens_hsa049660.66559046
107cAMP signaling pathway_Homo sapiens_hsa040240.66372024
108Cholinergic synapse_Homo sapiens_hsa047250.61962935
109Phagosome_Homo sapiens_hsa041450.60598301
110Glycosaminoglycan degradation_Homo sapiens_hsa005310.60473424
111Tuberculosis_Homo sapiens_hsa051520.60305120
112Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.59727652
113Pertussis_Homo sapiens_hsa051330.59516045
114Insulin secretion_Homo sapiens_hsa049110.58802028
115Retinol metabolism_Homo sapiens_hsa008300.58648391
116ABC transporters_Homo sapiens_hsa020100.58618540
117Staphylococcus aureus infection_Homo sapiens_hsa051500.58578034
118Regulation of autophagy_Homo sapiens_hsa041400.55484505
119Hepatitis C_Homo sapiens_hsa051600.55451947
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.55087765
121Vascular smooth muscle contraction_Homo sapiens_hsa042700.54869404
122Alzheimers disease_Homo sapiens_hsa050100.54769023
123Fatty acid metabolism_Homo sapiens_hsa012120.54346067
124Fatty acid elongation_Homo sapiens_hsa000620.54098837
125Salmonella infection_Homo sapiens_hsa051320.53651952
126Cocaine addiction_Homo sapiens_hsa050300.51920087
127Leukocyte transendothelial migration_Homo sapiens_hsa046700.51818676
128Basal transcription factors_Homo sapiens_hsa030220.51274423
129Renin secretion_Homo sapiens_hsa049240.51271228
130Osteoclast differentiation_Homo sapiens_hsa043800.49513354
131Oxytocin signaling pathway_Homo sapiens_hsa049210.49304385
132Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48330802
133Olfactory transduction_Homo sapiens_hsa047400.46480565
134Pyruvate metabolism_Homo sapiens_hsa006200.44756953
135Influenza A_Homo sapiens_hsa051640.43962728
136Rap1 signaling pathway_Homo sapiens_hsa040150.43484598
137Amphetamine addiction_Homo sapiens_hsa050310.43300496
138Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42998092
139Circadian rhythm_Homo sapiens_hsa047100.42718803
140Choline metabolism in cancer_Homo sapiens_hsa052310.42295043
141ErbB signaling pathway_Homo sapiens_hsa040120.41517432
142Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41226237
143T cell receptor signaling pathway_Homo sapiens_hsa046600.40357537
144Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38199100
145Gastric acid secretion_Homo sapiens_hsa049710.37118875
146Pentose phosphate pathway_Homo sapiens_hsa000300.36741363
147MAPK signaling pathway_Homo sapiens_hsa040100.35869209
148* Metabolic pathways_Homo sapiens_hsa011000.32414283
149Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.32073177
150Insulin resistance_Homo sapiens_hsa049310.31718250
151Primary bile acid biosynthesis_Homo sapiens_hsa001200.31359859
152Butanoate metabolism_Homo sapiens_hsa006500.31323778
153Huntingtons disease_Homo sapiens_hsa050160.31184459
154Sulfur relay system_Homo sapiens_hsa041220.31020037
155Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.30072322
156Propanoate metabolism_Homo sapiens_hsa006400.29998862
157Carbon metabolism_Homo sapiens_hsa012000.27556984
158Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.26783034
159Antigen processing and presentation_Homo sapiens_hsa046120.26397481
160Thyroid hormone synthesis_Homo sapiens_hsa049180.23760034
161Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.20702956
162Adipocytokine signaling pathway_Homo sapiens_hsa049200.18160444
163Vibrio cholerae infection_Homo sapiens_hsa051100.13186206
164Biosynthesis of amino acids_Homo sapiens_hsa012300.09424223
165Folate biosynthesis_Homo sapiens_hsa007900.08946985
166Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.05743076
167Adherens junction_Homo sapiens_hsa045200.03754220
168Amoebiasis_Homo sapiens_hsa051460.03145227

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