ST3GAL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi apparatus but can be proteolytically processed to a soluble form. This protein is a member of glycosyltransferase family 29. Mutations in this gene have been associated with autosomal recessive nonsymdromic mental retardation-12 (MRT12). Multiple transcript variants encoding several different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-myosin filament sliding (GO:0033275)6.73284077
2muscle filament sliding (GO:0030049)6.73284077
3sarcoplasmic reticulum calcium ion transport (GO:0070296)6.63251326
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.44060471
5L-phenylalanine catabolic process (GO:0006559)6.44060471
6L-phenylalanine metabolic process (GO:0006558)6.28960612
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.28960612
8regulation of skeletal muscle contraction (GO:0014819)5.98193934
9aromatic amino acid family catabolic process (GO:0009074)5.66960106
10skeletal muscle contraction (GO:0003009)5.41967119
11actin-mediated cell contraction (GO:0070252)5.38638861
12positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.33856472
13kynurenine metabolic process (GO:0070189)5.33598438
14triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.31696230
15alpha-linolenic acid metabolic process (GO:0036109)5.24221587
16glyoxylate metabolic process (GO:0046487)5.21439069
17lysine metabolic process (GO:0006553)5.11147370
18lysine catabolic process (GO:0006554)5.11147370
19indole-containing compound catabolic process (GO:0042436)5.01627518
20indolalkylamine catabolic process (GO:0046218)5.01627518
21tryptophan catabolic process (GO:0006569)5.01627518
22bile acid biosynthetic process (GO:0006699)4.95900760
23sulfur amino acid catabolic process (GO:0000098)4.84241965
24creatine metabolic process (GO:0006600)4.72490300
25cysteine metabolic process (GO:0006534)4.69862971
26tryptophan metabolic process (GO:0006568)4.68880994
27urea cycle (GO:0000050)4.67733373
28urea metabolic process (GO:0019627)4.67733373
29negative regulation of fibrinolysis (GO:0051918)4.67278465
30complement activation, alternative pathway (GO:0006957)4.63237851
31fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.61394403
32peptidyl-glutamic acid carboxylation (GO:0017187)4.59098914
33protein carboxylation (GO:0018214)4.59098914
34regulation of cholesterol esterification (GO:0010872)4.56127526
35regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.55211861
36synaptic vesicle maturation (GO:0016188)4.49800404
37regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.47542524
38cellular ketone body metabolic process (GO:0046950)4.46745827
39high-density lipoprotein particle remodeling (GO:0034375)4.40970776
40regulation of protein activation cascade (GO:2000257)4.40158565
41striated muscle contraction (GO:0006941)4.38222764
42skeletal muscle fiber development (GO:0048741)4.38076488
43regulation of fibrinolysis (GO:0051917)4.37897532
44neuronal action potential propagation (GO:0019227)4.36340341
45serine family amino acid catabolic process (GO:0009071)4.36200269
46regulation of triglyceride catabolic process (GO:0010896)4.29595563
47nitrogen cycle metabolic process (GO:0071941)4.28993838
48homocysteine metabolic process (GO:0050667)4.25920883
49dicarboxylic acid biosynthetic process (GO:0043650)4.22601886
50bile acid metabolic process (GO:0008206)4.18038425
51amino-acid betaine metabolic process (GO:0006577)4.16889342
52synaptic vesicle docking involved in exocytosis (GO:0016081)4.16860636
532-oxoglutarate metabolic process (GO:0006103)4.14141304
54regulation of complement activation (GO:0030449)4.13185953
55myotube cell development (GO:0014904)4.11700313
56alpha-amino acid catabolic process (GO:1901606)4.11033537
57negative regulation of calcium ion transmembrane transport (GO:1903170)4.08085031
58negative regulation of calcium ion transmembrane transporter activity (GO:1901020)4.08085031
59acylglycerol homeostasis (GO:0055090)4.07005738
60triglyceride homeostasis (GO:0070328)4.07005738
61aromatic amino acid family metabolic process (GO:0009072)4.05387394
62glutamate metabolic process (GO:0006536)4.03526263
63aspartate family amino acid catabolic process (GO:0009068)3.98570101
64acetyl-CoA metabolic process (GO:0006084)3.97984788
65plasma lipoprotein particle clearance (GO:0034381)3.93439112
66coenzyme catabolic process (GO:0009109)3.93048705
67cellular modified amino acid catabolic process (GO:0042219)3.91944068
68tyrosine metabolic process (GO:0006570)3.87518547
69cellular amino acid catabolic process (GO:0009063)3.87013009
70reverse cholesterol transport (GO:0043691)3.86768404
71regulation of cholesterol homeostasis (GO:2000188)3.85273547
72ketone body metabolic process (GO:1902224)3.84600131
73positive regulation of fatty acid beta-oxidation (GO:0032000)3.84323445
74actin filament-based movement (GO:0030048)3.84203142
75negative regulation of sterol transport (GO:0032372)3.82903832
76negative regulation of cholesterol transport (GO:0032375)3.82903832
77plasma lipoprotein particle remodeling (GO:0034369)3.79763031
78protein-lipid complex remodeling (GO:0034368)3.79763031
79macromolecular complex remodeling (GO:0034367)3.79763031
80short-chain fatty acid metabolic process (GO:0046459)3.79730669
81membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.75253019
82positive regulation of lipid catabolic process (GO:0050996)3.72766062
83fatty acid beta-oxidation (GO:0006635)3.72461563
84regulation of relaxation of muscle (GO:1901077)3.72318491
85ethanol oxidation (GO:0006069)3.72071184
86fatty acid transmembrane transport (GO:1902001)3.70582677
87phospholipid homeostasis (GO:0055091)3.70557893
88myofibril assembly (GO:0030239)3.70057013
89negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.69406796
90cardiac muscle contraction (GO:0060048)3.63939237
91response to inactivity (GO:0014854)3.62399815
92phospholipid efflux (GO:0033700)3.61854026
93synaptic vesicle exocytosis (GO:0016079)3.59533247
94bile acid and bile salt transport (GO:0015721)3.56708228
95fatty acid oxidation (GO:0019395)3.56180733
96regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.53793291
97regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.52412134
98lipid oxidation (GO:0034440)3.49503715
99monocarboxylic acid catabolic process (GO:0072329)3.48269572
100fatty acid catabolic process (GO:0009062)3.48199863
101regulation of synaptic vesicle exocytosis (GO:2000300)3.47421802
102carboxylic acid catabolic process (GO:0046395)3.47260047
103organic acid catabolic process (GO:0016054)3.47260047
104indolalkylamine metabolic process (GO:0006586)3.44699541
105regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.44320720
106regulation of calcium ion transmembrane transport (GO:1903169)3.44229545
107regulation of calcium ion transmembrane transporter activity (GO:1901019)3.44229545
108benzene-containing compound metabolic process (GO:0042537)3.44188576
109carnitine shuttle (GO:0006853)3.43793953
110glycine metabolic process (GO:0006544)3.42369413
111regulation of fatty acid beta-oxidation (GO:0031998)3.41360612
112drug catabolic process (GO:0042737)3.40756022
113valine metabolic process (GO:0006573)3.38752583
114establishment of mitochondrion localization (GO:0051654)3.38575301
115serine family amino acid metabolic process (GO:0009069)3.38469307
116positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.37712338
117muscle contraction (GO:0006936)3.33131945
118cholesterol homeostasis (GO:0042632)3.32806899
119cholesterol efflux (GO:0033344)3.32165683
120sarcomere organization (GO:0045214)3.31668468
121arginine metabolic process (GO:0006525)3.30965605
122positive regulation of fatty acid oxidation (GO:0046321)3.30941383
123cellular glucuronidation (GO:0052695)3.30241764
124sterol homeostasis (GO:0055092)3.28589844
125carnitine metabolic process (GO:0009437)3.25904719
126fibrinolysis (GO:0042730)3.24192674
127amine catabolic process (GO:0009310)3.23415254
128cellular biogenic amine catabolic process (GO:0042402)3.23415254
129cytolysis (GO:0019835)3.22337373
130muscle fiber development (GO:0048747)3.18699507
131negative regulation of lipase activity (GO:0060192)3.16374050
132drug transmembrane transport (GO:0006855)3.15445129
133regulation of short-term neuronal synaptic plasticity (GO:0048172)3.14542944
134plasma lipoprotein particle assembly (GO:0034377)3.14517911
135skeletal muscle tissue regeneration (GO:0043403)3.14280439
136negative regulation of phosphoprotein phosphatase activity (GO:0032515)3.13456156
137cofactor catabolic process (GO:0051187)3.13355184
138glutamate secretion (GO:0014047)3.11713182
139response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.11508693
140exogenous drug catabolic process (GO:0042738)3.11157426
141imidazole-containing compound metabolic process (GO:0052803)3.10476496
142regulation of bile acid biosynthetic process (GO:0070857)3.09906287
143negative regulation of protein localization to cell surface (GO:2000009)3.09287214
144regulation of synapse structural plasticity (GO:0051823)3.09275000
145adenosine receptor signaling pathway (GO:0001973)3.08634174
146neuromuscular synaptic transmission (GO:0007274)3.07108503
147regulation of synaptic vesicle transport (GO:1902803)3.06647272
148muscle system process (GO:0003012)3.02349417
149response to muscle activity (GO:0014850)3.00231360
150cardiac myofibril assembly (GO:0055003)2.97554508
151activation of protein kinase A activity (GO:0034199)2.95568016
152glycogen catabolic process (GO:0005980)2.93266944
153positive regulation of synapse maturation (GO:0090129)2.90585216
154membrane depolarization during action potential (GO:0086010)2.88455318
155regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.87617606
156positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.87323701
157regulation of cell communication by electrical coupling (GO:0010649)2.86346232
158mitochondrion transport along microtubule (GO:0047497)2.85679384
159establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.85679384
160postsynaptic membrane organization (GO:0001941)2.82346073
161negative regulation of cation channel activity (GO:2001258)2.81510020
162negative regulation of heart rate (GO:0010459)2.80622814
163positive regulation of myotube differentiation (GO:0010831)2.77527854
164neuronal ion channel clustering (GO:0045161)2.77220472
165regulation of voltage-gated calcium channel activity (GO:1901385)2.76460913
166regulation of actin filament-based movement (GO:1903115)2.76431534
167negative regulation of muscle contraction (GO:0045932)2.75954787
168positive regulation of neurotransmitter secretion (GO:0001956)2.75469450
169negative regulation of heart contraction (GO:0045822)2.73021171
170negative regulation of appetite (GO:0032099)2.71990613
171negative regulation of response to food (GO:0032096)2.71990613
172heart process (GO:0003015)2.68993227
173heart contraction (GO:0060047)2.68993227
174regulation of platelet aggregation (GO:0090330)2.68557554
175cardiac muscle hypertrophy (GO:0003300)2.67982574
176synaptic vesicle endocytosis (GO:0048488)2.67963291
177regulation of striated muscle contraction (GO:0006942)2.64432250
178protein insertion into membrane (GO:0051205)2.62821579
179striated muscle hypertrophy (GO:0014897)2.62126979
180muscle cell cellular homeostasis (GO:0046716)2.61638553
181regulation of cAMP-dependent protein kinase activity (GO:2000479)2.61616717
182regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.60654632
183glucan catabolic process (GO:0009251)2.60459153
184deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.59512904
185negative regulation of blood circulation (GO:1903523)2.59437572
186regulation of membrane repolarization (GO:0060306)2.59281108
187negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.58590227
188glycolytic process (GO:0006096)2.54626025
189gluconeogenesis (GO:0006094)2.54409399
190pyrimidine nucleobase catabolic process (GO:0006208)2.53600827
191synaptic transmission, glutamatergic (GO:0035249)2.53326765
192neurotransmitter secretion (GO:0007269)2.51398390
193calcium-mediated signaling using intracellular calcium source (GO:0035584)2.51085088
194relaxation of muscle (GO:0090075)2.49787130
195regulation of cation channel activity (GO:2001257)2.49536785
196cellular polysaccharide catabolic process (GO:0044247)2.48884641
197regulation of synapse maturation (GO:0090128)2.48737814
198dopamine transport (GO:0015872)2.48291271
199skeletal muscle tissue development (GO:0007519)2.46945518
200muscle hypertrophy (GO:0014896)2.46574402

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.49240632
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.67181327
3EZH2_22144423_ChIP-Seq_EOC_Human6.40574253
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.84755883
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.50835281
6LXR_22158963_ChIP-Seq_LIVER_Mouse5.29467423
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.39543188
8EGR1_23403033_ChIP-Seq_LIVER_Mouse4.34032449
9* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.70570414
10SRY_22984422_ChIP-ChIP_TESTIS_Rat3.31062464
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.11213984
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.59140655
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.58036083
14SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.45200462
15LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.23436624
16RARB_27405468_Chip-Seq_BRAIN_Mouse2.19702851
17CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.04642123
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.02473757
19CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.02000151
20CLOCK_20551151_ChIP-Seq_293T_Human1.96638258
21* REST_18959480_ChIP-ChIP_MESCs_Mouse1.96628553
22IKZF1_21737484_ChIP-ChIP_HCT116_Human1.94711679
23TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.93304625
24EZH2_27294783_Chip-Seq_ESCs_Mouse1.89412110
25SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.86722949
26MTF2_20144788_ChIP-Seq_MESCs_Mouse1.82604358
27ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.80346301
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.79932261
29* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.79797530
30JARID2_20075857_ChIP-Seq_MESCs_Mouse1.72701603
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.70908645
32* VDR_21846776_ChIP-Seq_THP-1_Human1.69214279
33* FOXA2_19822575_ChIP-Seq_HepG2_Human1.66938805
34GBX2_23144817_ChIP-Seq_PC3_Human1.66417102
35* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.61472069
36SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.58317139
37LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.57480270
38RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.56323614
39JARID2_20064375_ChIP-Seq_MESCs_Mouse1.53619553
40* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.52703707
41SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.52155846
42ELF1_20517297_ChIP-Seq_JURKAT_Human1.49261490
43LXR_22292898_ChIP-Seq_THP-1_Human1.47901436
44REST_21632747_ChIP-Seq_MESCs_Mouse1.45356924
45ZNF263_19887448_ChIP-Seq_K562_Human1.44615018
46CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.44118212
47EZH2_27304074_Chip-Seq_ESCs_Mouse1.43043957
48EZH2_18974828_ChIP-Seq_MESCs_Mouse1.42944542
49RNF2_18974828_ChIP-Seq_MESCs_Mouse1.42944542
50ESR2_21235772_ChIP-Seq_MCF-7_Human1.41915386
51HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.40201832
52IGF1R_20145208_ChIP-Seq_DFB_Human1.40061879
53SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.36698711
54STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.33438621
55BP1_19119308_ChIP-ChIP_Hs578T_Human1.29574330
56OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.29517317
57GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29206742
58* SA1_27219007_Chip-Seq_ERYTHROID_Human1.24910031
59* BCL6_27268052_Chip-Seq_Bcells_Human1.23867529
60SCL_19346495_ChIP-Seq_HPC-7_Human1.23152727
61TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.22876616
62MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.21709937
63* HNF4A_19822575_ChIP-Seq_HepG2_Human1.20270202
64* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.20242779
65EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.19425179
66TET1_21490601_ChIP-Seq_MESCs_Mouse1.19420229
67* SA1_27219007_Chip-Seq_Bcells_Human1.18095859
68* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.16944077
69GATA1_22025678_ChIP-Seq_K562_Human1.15777237
70WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.13981684
71SPI1_20517297_ChIP-Seq_HL60_Human1.12970649
72MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.12958711
73NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.12927962
74GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.10735354
75* KDM2B_26808549_Chip-Seq_JURKAT_Human1.09961763
76ESR1_20079471_ChIP-ChIP_T-47D_Human1.09019739
77TBX20_22080862_ChIP-Seq_HEART_Mouse1.07791517
78TBX20_22328084_ChIP-Seq_HEART_Mouse1.07791517
79CTCF_21964334_Chip-Seq_Bcells_Human1.06128823
80BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05874287
81SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.04867409
82ERG_21242973_ChIP-ChIP_JURKAT_Human1.04412151
83RNF2_27304074_Chip-Seq_ESCs_Mouse1.03958829
84GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02954017
85* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.02450005
86EED_16625203_ChIP-ChIP_MESCs_Mouse1.01467710
87OCT4_19829295_ChIP-Seq_ESCs_Human1.01268332
88TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99947554
89THAP11_20581084_ChIP-Seq_MESCs_Mouse0.99666299
90NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.99366654
91KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.98794997
92* TP53_23651856_ChIP-Seq_MEFs_Mouse0.97513231
93CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.97419115
94* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.97383438
95TCF7_22412390_ChIP-Seq_EML_Mouse0.95368822
96* RACK7_27058665_Chip-Seq_MCF-7_Human0.93950817
97TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93124983
98* SPI1_23127762_ChIP-Seq_K562_Human0.93038502
99DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92893115
100ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.92424233
101RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.92305375
102* NFIB_24661679_ChIP-Seq_LUNG_Mouse0.91758516
103SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.90948626
104PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89756787
105IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.88806255
106RXRA_24833708_ChIP-Seq_LIVER_Mouse0.86441714
107GATA1_19941826_ChIP-Seq_K562_Human0.85595310
108* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.84483385
109ESR1_21235772_ChIP-Seq_MCF-7_Human0.83835378
110KDM2B_26808549_Chip-Seq_SUP-B15_Human0.83594936
111CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.82300730
112* KDM2B_26808549_Chip-Seq_K562_Human0.81904812
113NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.81070288
114ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.80843976
115* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.80564038
116* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.80524319
117CREB1_26743006_Chip-Seq_LNCaP_Human0.80491475
118TRIM28_21343339_ChIP-Seq_HEK293_Human0.79891974
119SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.79849742
120FOXO3_23340844_ChIP-Seq_DLD1_Human0.78559944
121CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.78549389
122PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.77934504
123PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.77801515
124AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.76983272
125RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.76434965
126CTCF_27219007_Chip-Seq_Bcells_Human0.76164097
127* GATA1_19941827_ChIP-Seq_MEL_Mouse0.75974788
128EGR1_19032775_ChIP-ChIP_M12_Human0.75691375
129HTT_18923047_ChIP-ChIP_STHdh_Human0.75548820
130PPAR_26484153_Chip-Seq_NCI-H1993_Human0.73501356
131DROSHA_22980978_ChIP-Seq_HELA_Human0.73289665
132PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.72534748
133GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.72522513
134SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.72405537
135* KDM2B_26808549_Chip-Seq_DND41_Human0.71298673
136ESR1_15608294_ChIP-ChIP_MCF-7_Human0.71103415
137EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.70618525
138EP300_21415370_ChIP-Seq_HL-1_Mouse0.68582584
139GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.68380828
140BCOR_27268052_Chip-Seq_Bcells_Human0.68369468
141GATA4_25053715_ChIP-Seq_YYC3_Human0.68091272
142* P68_20966046_ChIP-Seq_HELA_Human0.68065908
143* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.67833940
144ZFP281_18757296_ChIP-ChIP_E14_Mouse0.67554421
145SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.67234707
146NRF2_20460467_ChIP-Seq_MEFs_Mouse0.66389106
147NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.66389106
148GATA2_19941826_ChIP-Seq_K562_Human0.65918780
149ELK3_25401928_ChIP-Seq_HUVEC_Human0.65569291
150* SMC4_20622854_ChIP-Seq_HELA_Human0.64758552
151RAD21_21589869_ChIP-Seq_MESCs_Mouse0.64382562
152KLF4_19829295_ChIP-Seq_ESCs_Human0.64188646
153ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.63599518
154Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.63335405
155TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.63060504
156ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.61166046
157KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.61076265
158RARA_24833708_ChIP-Seq_LIVER_Mouse0.60503044
159AUTS2_25519132_ChIP-Seq_293T-REX_Human0.59162710
160CTCF_21964334_ChIP-Seq_BJAB-B_Human0.58409567
161* TP63_22573176_ChIP-Seq_HFKS_Human0.57972569
162SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.57533504
163TET1_21451524_ChIP-Seq_MESCs_Mouse0.57265519
164RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.57038794

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.11796681
2MP0005360_urolithiasis6.41544925
3MP0005085_abnormal_gallbladder_physiolo5.50990119
4MP0005365_abnormal_bile_salt5.23507670
5MP0008875_abnormal_xenobiotic_pharmacok4.02953475
6MP0004859_abnormal_synaptic_plasticity3.86640251
7MP0003252_abnormal_bile_duct3.50297734
8MP0003806_abnormal_nucleotide_metabolis3.40545088
9MP0010329_abnormal_lipoprotein_level3.23455330
10MP0009840_abnormal_foam_cell3.21625691
11MP0005083_abnormal_biliary_tract3.01232083
12MP0005464_abnormal_platelet_physiology2.77891537
13MP0005332_abnormal_amino_acid2.73486357
14MP0004270_analgesia2.60218066
15MP0003195_calcinosis2.59821118
16MP0002837_dystrophic_cardiac_calcinosis2.40335177
17MP0005423_abnormal_somatic_nervous2.26914415
18MP0001666_abnormal_nutrient_absorption2.23138984
19MP0003191_abnormal_cellular_cholesterol2.21833151
20MP0005369_muscle_phenotype2.12443236
21MP0002118_abnormal_lipid_homeostasis2.10511737
22MP0003705_abnormal_hypodermis_morpholog2.05730181
23MP0003635_abnormal_synaptic_transmissio2.03773174
24MP0000609_abnormal_liver_physiology1.96012948
25MP0004130_abnormal_muscle_cell1.95037416
26MP0002138_abnormal_hepatobiliary_system1.90345346
27MP0005319_abnormal_enzyme/_coenzyme1.78108749
28MP0004233_abnormal_muscle_weight1.75067803
29MP0003646_muscle_fatigue1.74695364
30MP0004019_abnormal_vitamin_homeostasis1.73608690
31MP0003880_abnormal_central_pattern1.64026139
32MP0002063_abnormal_learning/memory/cond1.62875714
33MP0005584_abnormal_enzyme/coenzyme_acti1.59385515
34MP0001529_abnormal_vocalization1.57931921
35MP0008569_lethality_at_weaning1.57622626
36MP0009046_muscle_twitch1.54503859
37MP0002733_abnormal_thermal_nociception1.52628337
38MP0006276_abnormal_autonomic_nervous1.52483705
39MP0002064_seizures1.52417025
40MP0001905_abnormal_dopamine_level1.46015353
41MP0005670_abnormal_white_adipose1.45612331
42MP0003879_abnormal_hair_cell1.43298455
43MP0000733_abnormal_muscle_development1.41914591
44MP0003868_abnormal_feces_composition1.39653662
45MP0009745_abnormal_behavioral_response1.37986289
46MP0002735_abnormal_chemical_nociception1.36967391
47MP0009643_abnormal_urine_homeostasis1.34279037
48MP0002734_abnormal_mechanical_nocicepti1.32810795
49MP0002572_abnormal_emotion/affect_behav1.32791709
50MP0001968_abnormal_touch/_nociception1.30679294
51MP0005666_abnormal_adipose_tissue1.28765478
52MP0000751_myopathy1.26275530
53MP0001970_abnormal_pain_threshold1.25113383
54MP0002272_abnormal_nervous_system1.22523814
55MP0000604_amyloidosis1.19730804
56MP0005451_abnormal_body_composition1.18440247
57MP0001486_abnormal_startle_reflex1.17214789
58MP0006036_abnormal_mitochondrial_physio1.17101705
59MP0004142_abnormal_muscle_tone1.16925025
60MP0004811_abnormal_neuron_physiology1.16881476
61MP0004036_abnormal_muscle_relaxation1.14350541
62MP0008004_abnormal_stomach_pH1.13497880
63MP0002971_abnormal_brown_adipose1.12683951
64MP0005410_abnormal_fertilization1.12533286
65MP0004484_altered_response_of1.10580901
66MP0005330_cardiomyopathy1.08863793
67MP0002269_muscular_atrophy1.08343300
68MP0002067_abnormal_sensory_capabilities1.08088454
69MP0000749_muscle_degeneration1.07028510
70MP0003656_abnormal_erythrocyte_physiolo1.05057832
71MP0003329_amyloid_beta_deposits1.04562442
72MP0002078_abnormal_glucose_homeostasis1.02638907
73MP0000013_abnormal_adipose_tissue1.01744750
74MP0005535_abnormal_body_temperature1.01182017
75MP0000598_abnormal_liver_morphology1.00131838
76MP0001764_abnormal_homeostasis0.99485306
77MP0004084_abnormal_cardiac_muscle0.98600582
78MP0004087_abnormal_muscle_fiber0.98569398
79MP0002066_abnormal_motor_capabilities/c0.97755871
80MP0002736_abnormal_nociception_after0.96953022
81MP0005375_adipose_tissue_phenotype0.95687556
82MP0000747_muscle_weakness0.95535604
83MP0003303_peritoneal_inflammation0.94973373
84MP0004185_abnormal_adipocyte_glucose0.94060419
85MP0010368_abnormal_lymphatic_system0.93360677
86MP0008260_abnormal_autophagy0.90298844
87MP0000343_altered_response_to0.90127288
88MP0003690_abnormal_glial_cell0.88900334
89MP0005334_abnormal_fat_pad0.88203184
90MP0001501_abnormal_sleep_pattern0.87733497
91MP0004085_abnormal_heartbeat0.85310140
92MP0004924_abnormal_behavior0.83920173
93MP0005386_behavior/neurological_phenoty0.83920173
94MP0003186_abnormal_redox_activity0.81612038
95MP0001756_abnormal_urination0.81083273
96MP0009764_decreased_sensitivity_to0.80757707
97MP0009763_increased_sensitivity_to0.80632757
98MP0009642_abnormal_blood_homeostasis0.80277237
99MP0005058_abnormal_lysosome_morphology0.78890894
100MP0002638_abnormal_pupillary_reflex0.77621576
101MP0003075_altered_response_to0.77472464
102MP0004215_abnormal_myocardial_fiber0.76811882
103MP0005636_abnormal_mineral_homeostasis0.76424872
104MP0002653_abnormal_ependyma_morphology0.76196104
105MP0004043_abnormal_pH_regulation0.75358990
106MP0005620_abnormal_muscle_contractility0.75124608
107MP0002882_abnormal_neuron_morphology0.74016317
108MP0002108_abnormal_muscle_morphology0.73379604
109MP0001984_abnormal_olfaction0.72541410
110MP0008961_abnormal_basal_metabolism0.71335100
111MP0008469_abnormal_protein_level0.70148462
112MP0005266_abnormal_metabolism0.69734850
113MP0005448_abnormal_energy_balance0.69700044
114MP0002557_abnormal_social/conspecific_i0.69326409
115MP0006035_abnormal_mitochondrial_morpho0.69172461
116MP0009278_abnormal_bone_marrow0.69124928
117MP0005647_abnormal_sex_gland0.68777924
118MP0000003_abnormal_adipose_tissue0.67437341
119MP0003221_abnormal_cardiomyocyte_apopto0.66932853
120MP0002254_reproductive_system_inflammat0.66860695
121MP0008775_abnormal_heart_ventricle0.66453220
122MP0000955_abnormal_spinal_cord0.66412793
123MP0003011_delayed_dark_adaptation0.66155303
124MP0005167_abnormal_blood-brain_barrier0.65439572
125MP0008874_decreased_physiological_sensi0.65386232
126MP0002972_abnormal_cardiac_muscle0.64989200
127MP0002822_catalepsy0.64606948
128MP0001544_abnormal_cardiovascular_syste0.62124084
129MP0005385_cardiovascular_system_phenoty0.62124084
130MP0010630_abnormal_cardiac_muscle0.61879703
131MP0000230_abnormal_systemic_arterial0.61821215
132MP0005623_abnormal_meninges_morphology0.61043554
133MP0005376_homeostasis/metabolism_phenot0.60973851
134MP0009780_abnormal_chondrocyte_physiolo0.60418466
135MP0000778_abnormal_nervous_system0.60149327
136MP0010234_abnormal_vibrissa_follicle0.59315805
137MP0002909_abnormal_adrenal_gland0.58976654
138MP0000759_abnormal_skeletal_muscle0.56981127
139MP0004147_increased_porphyrin_level0.56224176
140MP0009115_abnormal_fat_cell0.55656848
141MP0002332_abnormal_exercise_endurance0.54699715
142MP0006138_congestive_heart_failure0.54135878
143MP0002106_abnormal_muscle_physiology0.53577990
144MP0003300_gastrointestinal_ulcer0.52440722
145MP0000750_abnormal_muscle_regeneration0.51811153
146MP0002136_abnormal_kidney_physiology0.51586576
147MP0003137_abnormal_impulse_conducting0.51310582
148MP0005166_decreased_susceptibility_to0.51163520
149MP0004510_myositis0.51077220
150MP0003283_abnormal_digestive_organ0.51003411
151MP0004145_abnormal_muscle_electrophysio0.50927212
152MP0005084_abnormal_gallbladder_morpholo0.49115574
153MP0001661_extended_life_span0.48893382

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)8.14365291
2Nemaline bodies (HP:0003798)8.04411203
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)7.83452448
4Type 1 muscle fiber predominance (HP:0003803)6.52901636
5Deep venous thrombosis (HP:0002625)6.17232180
6Abnormality of aromatic amino acid family metabolism (HP:0004338)5.87723413
7Intrahepatic cholestasis (HP:0001406)5.65785556
8Xanthomatosis (HP:0000991)5.37358110
9Myopathic facies (HP:0002058)5.16118277
10Abnormality of monocarboxylic acid metabolism (HP:0010996)5.05898949
11Hyperlipoproteinemia (HP:0010980)4.64644248
12Complement deficiency (HP:0004431)4.61295476
13Prolonged partial thromboplastin time (HP:0003645)4.47888606
14Hypobetalipoproteinemia (HP:0003563)4.43539346
15Ketosis (HP:0001946)4.41882318
16Distal arthrogryposis (HP:0005684)4.38199805
17Abnormality of skeletal muscle fiber size (HP:0012084)4.25698299
18Muscle hypertrophy of the lower extremities (HP:0008968)4.24160521
19Hyperammonemia (HP:0001987)4.22014791
20Centrally nucleated skeletal muscle fibers (HP:0003687)4.12900583
21EMG: myopathic abnormalities (HP:0003458)4.08836435
22Muscle fiber splitting (HP:0003555)4.07125669
23Hypoglycemic coma (HP:0001325)3.88350682
24Rimmed vacuoles (HP:0003805)3.84654471
25Hypoalphalipoproteinemia (HP:0003233)3.84206336
26Hyperglycinuria (HP:0003108)3.84134793
27Increased variability in muscle fiber diameter (HP:0003557)3.83054847
28Hyperglycinemia (HP:0002154)3.81332154
29Hypolipoproteinemia (HP:0010981)3.80267888
30Ketoacidosis (HP:0001993)3.75997413
31Calf muscle hypertrophy (HP:0008981)3.69796450
32Abnormality of glycine metabolism (HP:0010895)3.67888817
33Abnormality of serine family amino acid metabolism (HP:0010894)3.67888817
34Abnormality of glutamine family amino acid metabolism (HP:0010902)3.67822297
35Epidermoid cyst (HP:0200040)3.64456220
36Abnormality of the calf musculature (HP:0001430)3.58065228
37Round ear (HP:0100830)3.56763171
38Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.49574492
39Abnormality of fatty-acid metabolism (HP:0004359)3.46759003
40Abnormality of sulfur amino acid metabolism (HP:0004339)3.43973122
41Abnormality of the common coagulation pathway (HP:0010990)3.42427487
42Ulnar deviation of the wrist (HP:0003049)3.42037667
43Joint hemorrhage (HP:0005261)3.35160142
44Abnormality of complement system (HP:0005339)3.32542988
45Calcaneovalgus deformity (HP:0001848)3.27418213
46Muscle stiffness (HP:0003552)3.25373120
47Distal lower limb amyotrophy (HP:0008944)3.24065686
48Neck muscle weakness (HP:0000467)3.23235838
49Abnormality of the left ventricular outflow tract (HP:0011103)3.18241690
50Subaortic stenosis (HP:0001682)3.18241690
51Increased connective tissue (HP:0009025)3.13096924
52Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.10785619
53Prolonged bleeding time (HP:0003010)3.10549082
54Abnormality of aspartate family amino acid metabolism (HP:0010899)3.10450906
55Gout (HP:0001997)3.07597949
56Menorrhagia (HP:0000132)3.06973896
57Distal lower limb muscle weakness (HP:0009053)3.06279843
58Myotonia (HP:0002486)3.04817376
59Myoglobinuria (HP:0002913)2.98990557
60Abnormality of methionine metabolism (HP:0010901)2.93963936
61Deformed tarsal bones (HP:0008119)2.93008445
62Difficulty running (HP:0009046)2.91550262
63Fat malabsorption (HP:0002630)2.90925006
64Frequent falls (HP:0002359)2.89883409
65Purpura (HP:0000979)2.86779073
66Lower limb amyotrophy (HP:0007210)2.86525485
67Skin nodule (HP:0200036)2.85395820
68Hypercholesterolemia (HP:0003124)2.83164075
69Fetal akinesia sequence (HP:0001989)2.82926893
70Abnormality of the intrinsic pathway (HP:0010989)2.80229079
71Exercise-induced myalgia (HP:0003738)2.74036551
72Abnormality of purine metabolism (HP:0004352)2.71410197
73Increased mean platelet volume (HP:0011877)2.70998776
74Myocardial infarction (HP:0001658)2.68076597
75Cholelithiasis (HP:0001081)2.65374982
76Hyperbilirubinemia (HP:0002904)2.60325004
77Metabolic acidosis (HP:0001942)2.59190025
78Hepatocellular carcinoma (HP:0001402)2.58274460
79Abnormal gallbladder morphology (HP:0012437)2.57564719
80Delayed CNS myelination (HP:0002188)2.56582384
81Dicarboxylic aciduria (HP:0003215)2.56523765
82Abnormality of dicarboxylic acid metabolism (HP:0010995)2.56523765
83Spinal rigidity (HP:0003306)2.56350680
84Abnormality of nucleobase metabolism (HP:0010932)2.54950909
85Systemic lupus erythematosus (HP:0002725)2.54794847
86Difficulty climbing stairs (HP:0003551)2.53572747
87Late onset (HP:0003584)2.52423860
88EMG: neuropathic changes (HP:0003445)2.51247041
89Petechiae (HP:0000967)2.49404418
90Bundle branch block (HP:0011710)2.48438932
91Ankle clonus (HP:0011448)2.46936725
92Abnormal platelet volume (HP:0011876)2.46684345
93Abnormality of serum amino acid levels (HP:0003112)2.42379921
94Malignant hyperthermia (HP:0002047)2.41211431
95Conjugated hyperbilirubinemia (HP:0002908)2.40802431
96Generalized muscle weakness (HP:0003324)2.36682180
97Slender build (HP:0001533)2.36019779
98Neonatal onset (HP:0003623)2.35995417
99Exercise-induced muscle cramps (HP:0003710)2.35751858
100Focal motor seizures (HP:0011153)2.35427616
101Myokymia (HP:0002411)2.34635841
102Absent phalangeal crease (HP:0006109)2.34455713
103Abnormality of the foot musculature (HP:0001436)2.33533142
104Abnormality of the Achilles tendon (HP:0005109)2.30545988
105Paralysis (HP:0003470)2.29375958
106Mildly elevated creatine phosphokinase (HP:0008180)2.28599269
107Areflexia of lower limbs (HP:0002522)2.28194673
108Foot dorsiflexor weakness (HP:0009027)2.27099104
109Spontaneous abortion (HP:0005268)2.23122511
110Ragged-red muscle fibers (HP:0003200)2.23023003
111Abnormality of pyrimidine metabolism (HP:0004353)2.22032334
112Limb dystonia (HP:0002451)2.21981127
113Bulbar palsy (HP:0001283)2.21841969
114Weak cry (HP:0001612)2.21610983
115Lethargy (HP:0001254)2.21323440
116Generalized aminoaciduria (HP:0002909)2.21151362
117Hyperinsulinemic hypoglycemia (HP:0000825)2.21131949
118Scapular winging (HP:0003691)2.18049899
119Spastic diplegia (HP:0001264)2.17210325
120Abnormal cartilage morphology (HP:0002763)2.16786641
121Hypoglycemic seizures (HP:0002173)2.16395068
122Rhabdomyolysis (HP:0003201)2.16075453
123Waddling gait (HP:0002515)2.15994216
124Abnormal gallbladder physiology (HP:0012438)2.15768552
125Cholecystitis (HP:0001082)2.15768552
126Mitral stenosis (HP:0001718)2.14617754
127Sudden death (HP:0001699)2.13171036
128Abnormality of proline metabolism (HP:0010907)2.11806659
129Hydroxyprolinuria (HP:0003080)2.11806659
130Limb-girdle muscle atrophy (HP:0003797)2.10868855
131Visual hallucinations (HP:0002367)2.10365429
132Glomerulonephritis (HP:0000099)2.09638590
133Abnormality of binocular vision (HP:0011514)2.08866930
134Diplopia (HP:0000651)2.08866930
135Dilated cardiomyopathy (HP:0001644)2.08516394
136Increased purine levels (HP:0004368)2.07745372
137Hyperuricemia (HP:0002149)2.07745372
138Gowers sign (HP:0003391)2.07224274
139Hyporeflexia of lower limbs (HP:0002600)2.07200553
140Cerebral edema (HP:0002181)2.06760354
141Esophageal varix (HP:0002040)2.06700710
142Epistaxis (HP:0000421)2.05055319
143Sensorimotor neuropathy (HP:0007141)2.02716715
144Steatorrhea (HP:0002570)2.02697227
145Hyperglycemia (HP:0003074)2.02397226
146Abnormality of the calcaneus (HP:0008364)2.01841156
147Abnormality of the gallbladder (HP:0005264)1.97384461
148Amyloidosis (HP:0011034)1.96824541
149Vomiting (HP:0002013)1.95242701
150Vascular calcification (HP:0004934)1.95123565
151Hypochromic microcytic anemia (HP:0004840)1.93069130
152Death in childhood (HP:0003819)1.92252612
153Asymmetric septal hypertrophy (HP:0001670)1.91594360
154Shoulder girdle muscle weakness (HP:0003547)1.89741660
155Abnormality of the hip-girdle musculature (HP:0001445)1.89314998
156Abnormality of the musculature of the pelvis (HP:0001469)1.89314998
157* Irritability (HP:0000737)1.87684535
158Pancreatitis (HP:0001733)1.87094295
159Abnormal atrioventricular conduction (HP:0005150)1.85875964
160Atrioventricular block (HP:0001678)1.85792197
161Increased intramyocellular lipid droplets (HP:0012240)1.84881991
162Hemorrhage of the eye (HP:0011885)1.84668955
163Limb-girdle muscle weakness (HP:0003325)1.83451138
164Recurrent gram-negative bacterial infections (HP:0005420)1.82769046
165Malnutrition (HP:0004395)1.82415147
166Reticulocytosis (HP:0001923)1.81841816
167Status epilepticus (HP:0002133)1.80918838
168Steppage gait (HP:0003376)1.80789285
169Abnormal finger flexion creases (HP:0006143)1.80561168
170Turricephaly (HP:0000262)1.80450259
171Heart block (HP:0012722)1.79875578
172Lymphangioma (HP:0100764)1.78457433
173Polycythemia (HP:0001901)1.78337743
174Right ventricular cardiomyopathy (HP:0011663)1.77913340
175Cardiovascular calcification (HP:0011915)1.77905340
176Lipoatrophy (HP:0100578)1.76059912
177Nephritis (HP:0000123)1.75174099
178Respiratory insufficiency due to muscle weakness (HP:0002747)1.74891420
179Increased muscle lipid content (HP:0009058)1.74644036
180Failure to thrive in infancy (HP:0001531)1.73197434
181Achilles tendon contracture (HP:0001771)1.72609346
182Pelvic girdle muscle weakness (HP:0003749)1.72518035
183Fatigable weakness (HP:0003473)1.71445953
184Abnormality of the neuromuscular junction (HP:0003398)1.71445953
185Atonic seizures (HP:0010819)1.71322991
186Generalized tonic-clonic seizures (HP:0002069)1.70381479
187Spastic gait (HP:0002064)1.70176328
188Abnormal pupillary function (HP:0007686)1.69006133
189Rapidly progressive (HP:0003678)1.68036019
190Exercise intolerance (HP:0003546)1.67129346

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.51676560
2TRIB34.07687520
3TAOK33.68134816
4ERN13.16396896
5PKN23.07692626
6SIK12.95166167
7MARK12.86793593
8FGFR42.49516696
9TTN2.47642771
10RIPK12.34265178
11PINK12.04533039
12PHKG11.86216955
13PHKG21.86216955
14MAP2K41.78488653
15INSRR1.67802514
16CCNB11.66500766
17PTK61.57898332
18TESK11.55754749
19MAP2K71.52087055
20MAP3K41.48047363
21MAP3K71.47712889
22KSR21.42755208
23OBSCN1.41308129
24DAPK21.40363382
25TESK21.35702891
26TAOK21.33802086
27LMTK21.32744501
28TAOK11.32421283
29GRK51.29451272
30PRPF4B1.25878599
31MOS1.23643416
32ICK1.22060445
33ARAF1.21090412
34RIPK41.20860066
35NEK11.20412664
36MAP3K91.19271028
37PDK31.19105187
38PDK41.19105187
39CDK191.15873873
40ERBB41.13167125
41EPHB11.12411335
42NTRK31.10699621
43MAPK111.10655861
44PIM21.10443728
45LIMK11.08084396
46CAMK2B1.06498978
47MINK11.06028396
48MAPKAPK31.04866437
49MAP3K61.02818543
50NTRK21.02352475
51MST1R1.02201740
52PDGFRA1.01808721
53JAK11.00411468
54UHMK11.00305524
55CDK140.99990454
56MAP3K100.99000966
57TYK20.98576330
58MARK20.97692092
59JAK20.97623650
60PRKAA20.96550259
61EPHB20.95923059
62PIK3CG0.95072873
63MAP3K130.94621856
64FLT30.93594823
65PDPK10.93002082
66MAP2K30.92566783
67MAP4K20.92326404
68MAPK120.91670862
69RET0.90860674
70CAMK10.90303802
71MUSK0.90228600
72ABL20.89318045
73BMX0.88563430
74MAPK130.86772861
75PLK20.86509901
76CDK150.86217013
77CAMK1D0.85618522
78CDK11A0.85370013
79PRKAA10.85168299
80PAK60.85120886
81PAK30.83279959
82CSNK1G30.82591865
83LATS20.82585385
84CDK50.81043503
85CAMK2A0.80756237
86CDK180.80205907
87STK380.78682447
88TBK10.77985860
89CAMK2D0.76839422
90LATS10.76348459
91CAMKK10.75399616
92NEK90.71160673
93PDK10.70626674
94EPHA40.68806991
95PDK20.67732488
96PRKD30.67500047
97PTK20.67219101
98PRKD10.66481087
99CAMK1G0.66371118
100DMPK0.65153419
101ERBB20.64906917
102MYLK0.64899496
103CSNK1G20.63609451
104PRKCH0.63330290
105MAP3K10.62765522
106DDR20.62545256
107DAPK10.62333601
108MAP3K110.62255460
109PRKCZ0.61445032
110PIK3CA0.61055840
111SGK30.60517341
112PRKACG0.60153654
113MAP2K10.59772082
114NTRK10.59450891
115SYK0.56677086
116PKN10.56406424
117FGFR20.56192951
118CAMK2G0.55468488
119PAK10.55396071
120MTOR0.54066200
121DYRK20.51049001
122SIK20.50368716
123GRK60.50234007
124MAP3K20.50180251
125WNK40.49429711
126MAP3K50.48649350
127GSK3A0.48388469
128IRAK20.48230767
129TYRO30.47873174
130DAPK30.46751898
131STK110.46627494
132PRKCG0.46091134
133PRKG10.45884395
134DYRK1B0.45712009
135CAMK40.45502195
136PTK2B0.43058254
137MAPK70.42105806
138EEF2K0.41965551
139BTK0.41658005
140MET0.40593807
141MAP2K20.39972626
142MAPKAPK50.39474918
143MAP2K60.39222431
144MAPK100.38967932
145ROCK10.38919677
146AKT20.37909529
147TIE10.37741637
148TGFBR20.36382380
149ZAP700.35988879
150MAPK40.35979720
151KDR0.35059605
152TNK20.34708484
153RPS6KA30.34567210
154CSK0.34338498
155FGFR30.33290581

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.02501913
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.99851071
3Nitrogen metabolism_Homo sapiens_hsa009103.69204306
4Arginine biosynthesis_Homo sapiens_hsa002203.09861689
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.88226531
6Fatty acid degradation_Homo sapiens_hsa000712.76809545
7Synaptic vesicle cycle_Homo sapiens_hsa047212.72303913
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.71186491
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.64464832
10Tryptophan metabolism_Homo sapiens_hsa003802.56751022
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.38015136
12Butanoate metabolism_Homo sapiens_hsa006502.34581697
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.34399357
14Propanoate metabolism_Homo sapiens_hsa006402.31908975
15Complement and coagulation cascades_Homo sapiens_hsa046102.30476439
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.10132550
17Fatty acid metabolism_Homo sapiens_hsa012122.07024257
18PPAR signaling pathway_Homo sapiens_hsa033202.04331691
19Circadian entrainment_Homo sapiens_hsa047131.92376679
20Peroxisome_Homo sapiens_hsa041461.88620543
21Oxytocin signaling pathway_Homo sapiens_hsa049211.84643793
22Pentose and glucuronate interconversions_Homo sapiens_hsa000401.80693690
23Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.77139547
24Platelet activation_Homo sapiens_hsa046111.76739134
25Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.73834325
26Nicotine addiction_Homo sapiens_hsa050331.73153771
27Amphetamine addiction_Homo sapiens_hsa050311.65771310
28Calcium signaling pathway_Homo sapiens_hsa040201.65055204
29Long-term potentiation_Homo sapiens_hsa047201.64902022
30Bile secretion_Homo sapiens_hsa049761.63317316
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.61431409
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.61022661
33beta-Alanine metabolism_Homo sapiens_hsa004101.59675584
34Morphine addiction_Homo sapiens_hsa050321.58645035
35Dopaminergic synapse_Homo sapiens_hsa047281.56312942
36Pyruvate metabolism_Homo sapiens_hsa006201.53499212
37Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.51724482
38Carbon metabolism_Homo sapiens_hsa012001.48435449
39Staphylococcus aureus infection_Homo sapiens_hsa051501.48316573
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.48235487
41Caffeine metabolism_Homo sapiens_hsa002321.40367735
42Chemical carcinogenesis_Homo sapiens_hsa052041.39139469
43Cocaine addiction_Homo sapiens_hsa050301.38613742
44Phenylalanine metabolism_Homo sapiens_hsa003601.37743282
45Gap junction_Homo sapiens_hsa045401.37446167
46Glutamatergic synapse_Homo sapiens_hsa047241.36141196
47Histidine metabolism_Homo sapiens_hsa003401.34133577
48Cholinergic synapse_Homo sapiens_hsa047251.33299759
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.29958741
50Starch and sucrose metabolism_Homo sapiens_hsa005001.29607270
51Steroid hormone biosynthesis_Homo sapiens_hsa001401.29524268
52Biosynthesis of amino acids_Homo sapiens_hsa012301.29099940
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.26528364
54Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.21123852
55Gastric acid secretion_Homo sapiens_hsa049711.20634004
56Selenocompound metabolism_Homo sapiens_hsa004501.19780817
57Drug metabolism - other enzymes_Homo sapiens_hsa009831.14881617
58cGMP-PKG signaling pathway_Homo sapiens_hsa040221.13229855
59Tyrosine metabolism_Homo sapiens_hsa003501.12511732
60Fat digestion and absorption_Homo sapiens_hsa049751.12160671
61Salivary secretion_Homo sapiens_hsa049701.11175812
62Circadian rhythm_Homo sapiens_hsa047101.11078300
63Retinol metabolism_Homo sapiens_hsa008301.10738712
64Alcoholism_Homo sapiens_hsa050341.09173812
65Sulfur metabolism_Homo sapiens_hsa009201.08879552
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.07290467
67Cysteine and methionine metabolism_Homo sapiens_hsa002701.06496657
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.05065112
69Fatty acid elongation_Homo sapiens_hsa000621.04591627
70Renin secretion_Homo sapiens_hsa049241.03352641
71ABC transporters_Homo sapiens_hsa020101.02117239
72Vascular smooth muscle contraction_Homo sapiens_hsa042701.01921162
73Parkinsons disease_Homo sapiens_hsa050120.99522820
74Long-term depression_Homo sapiens_hsa047300.99043037
75GnRH signaling pathway_Homo sapiens_hsa049120.98550974
76Lysine degradation_Homo sapiens_hsa003100.94836626
77VEGF signaling pathway_Homo sapiens_hsa043700.93795127
78Insulin secretion_Homo sapiens_hsa049110.93126075
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91255509
80Arginine and proline metabolism_Homo sapiens_hsa003300.91193196
81Glycosaminoglycan degradation_Homo sapiens_hsa005310.88999064
82Glioma_Homo sapiens_hsa052140.87331981
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86594484
84Serotonergic synapse_Homo sapiens_hsa047260.86557565
85Collecting duct acid secretion_Homo sapiens_hsa049660.84057873
86Olfactory transduction_Homo sapiens_hsa047400.83292908
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.81995896
88Cyanoamino acid metabolism_Homo sapiens_hsa004600.80740548
89Glycerolipid metabolism_Homo sapiens_hsa005610.80725222
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.78072993
91Folate biosynthesis_Homo sapiens_hsa007900.77963260
92ECM-receptor interaction_Homo sapiens_hsa045120.77011295
93Fatty acid biosynthesis_Homo sapiens_hsa000610.75732546
94Endocytosis_Homo sapiens_hsa041440.75393890
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75086749
96Alzheimers disease_Homo sapiens_hsa050100.73857847
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.73766924
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72529864
99cAMP signaling pathway_Homo sapiens_hsa040240.72231463
100Maturity onset diabetes of the young_Homo sapiens_hsa049500.72065037
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.70205871
102Focal adhesion_Homo sapiens_hsa045100.68705015
103Sulfur relay system_Homo sapiens_hsa041220.68490438
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.67790972
105Insulin resistance_Homo sapiens_hsa049310.66523962
106Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66058686
107Regulation of autophagy_Homo sapiens_hsa041400.65545115
108Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64716969
109MAPK signaling pathway_Homo sapiens_hsa040100.63211221
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58941587
111ErbB signaling pathway_Homo sapiens_hsa040120.57869797
112Prion diseases_Homo sapiens_hsa050200.57023821
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56585857
114Steroid biosynthesis_Homo sapiens_hsa001000.52015909
115Oocyte meiosis_Homo sapiens_hsa041140.50210173
116Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47352518
117Axon guidance_Homo sapiens_hsa043600.46520619
118Shigellosis_Homo sapiens_hsa051310.45305546
119Pentose phosphate pathway_Homo sapiens_hsa000300.44966822
120Vibrio cholerae infection_Homo sapiens_hsa051100.43453091
121Glucagon signaling pathway_Homo sapiens_hsa049220.42886986
122Vitamin digestion and absorption_Homo sapiens_hsa049770.42299926
123Salmonella infection_Homo sapiens_hsa051320.41877082
124Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41812087
125Vitamin B6 metabolism_Homo sapiens_hsa007500.41388867
126AMPK signaling pathway_Homo sapiens_hsa041520.41033476
127* Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39830748
128Fructose and mannose metabolism_Homo sapiens_hsa000510.38668160
129Melanogenesis_Homo sapiens_hsa049160.38120985
130Ras signaling pathway_Homo sapiens_hsa040140.35960262
131Choline metabolism in cancer_Homo sapiens_hsa052310.35708774
132Insulin signaling pathway_Homo sapiens_hsa049100.35100530
133Galactose metabolism_Homo sapiens_hsa000520.32140641
134Type II diabetes mellitus_Homo sapiens_hsa049300.31807116
135Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.31227761
136Glutathione metabolism_Homo sapiens_hsa004800.30711665
137* Metabolic pathways_Homo sapiens_hsa011000.27575983
138Central carbon metabolism in cancer_Homo sapiens_hsa052300.21677283
139Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.18612952
140Dilated cardiomyopathy_Homo sapiens_hsa054140.18026031
141Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.16949789
142Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.16375614
143Glycerophospholipid metabolism_Homo sapiens_hsa005640.15658580
144Cardiac muscle contraction_Homo sapiens_hsa042600.14294535
145Longevity regulating pathway - mammal_Homo sapiens_hsa042110.14288435
146Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.13563949
147Carbohydrate digestion and absorption_Homo sapiens_hsa049730.12934560
148Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.12441888
149Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.10371469
150Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.09165017
151One carbon pool by folate_Homo sapiens_hsa006700.07767963
152Amoebiasis_Homo sapiens_hsa051460.06176292
153Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.05111026
154mTOR signaling pathway_Homo sapiens_hsa041500.01327150
155alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.00738557
156GABAergic synapse_Homo sapiens_hsa04727-0.0855814
157Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0580521
158Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0465568
159Aldosterone synthesis and secretion_Homo sapiens_hsa04925-0.0389824
160Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961-0.0027275
161Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412-0.0014791

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