SSX4B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. Chromosome Xp11 contains a segmental duplication resulting in two identical copies of synovial sarcoma, X breakpoint 4, SSX4 and SSX4B, in tail-to-tail orientation. This gene, SSX4B, represents the more centromeric copy. Two transcript variants encoding distinct isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of retinoic acid receptor signaling pathway (GO:0048385)9.11428282
2melanin biosynthetic process (GO:0042438)6.71332328
3melanin metabolic process (GO:0006582)6.05939163
4secondary metabolite biosynthetic process (GO:0044550)5.53425688
5mitotic sister chromatid segregation (GO:0000070)5.49874477
6mitotic chromosome condensation (GO:0007076)5.15762040
7sister chromatid segregation (GO:0000819)5.05012442
8DNA strand elongation involved in DNA replication (GO:0006271)4.59139044
9DNA strand elongation (GO:0022616)4.51591995
10response to UV-C (GO:0010225)4.49909887
11ventricular cardiac muscle cell development (GO:0055015)4.37100419
12DNA replication checkpoint (GO:0000076)4.34481625
13rRNA modification (GO:0000154)4.32962030
14rRNA methylation (GO:0031167)4.31205497
15nuclear pore complex assembly (GO:0051292)4.18885214
16DNA replication initiation (GO:0006270)4.18512764
17telomere maintenance via semi-conservative replication (GO:0032201)4.16011881
18negative regulation of cell cycle arrest (GO:0071157)4.02729734
19DNA topological change (GO:0006265)4.01619568
20mitotic metaphase plate congression (GO:0007080)3.99820212
21DNA unwinding involved in DNA replication (GO:0006268)3.81395823
22positive regulation of DNA-dependent DNA replication (GO:2000105)3.80149559
23regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.79308030
24mitotic nuclear envelope disassembly (GO:0007077)3.75391794
25nuclear pore organization (GO:0006999)3.74604859
26chromosome segregation (GO:0007059)3.59647954
27regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.57699607
28negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)3.50363848
29chromosome condensation (GO:0030261)3.49879167
30regulation of DNA endoreduplication (GO:0032875)3.48750002
31regulation of mitotic spindle organization (GO:0060236)3.48390503
32CENP-A containing nucleosome assembly (GO:0034080)3.47650661
33telomere maintenance via recombination (GO:0000722)3.46470982
34membrane disassembly (GO:0030397)3.43806098
35nuclear envelope disassembly (GO:0051081)3.43806098
36telomere maintenance via telomere lengthening (GO:0010833)3.39861557
37mitotic recombination (GO:0006312)3.39496788
38regulation of spindle organization (GO:0090224)3.36642471
39regulation of sister chromatid cohesion (GO:0007063)3.36114869
40metaphase plate congression (GO:0051310)3.29679980
41chromatin remodeling at centromere (GO:0031055)3.29432126
42regulation of translational fidelity (GO:0006450)3.25432151
43synapsis (GO:0007129)3.24747856
44nucleotide-excision repair, DNA gap filling (GO:0006297)3.22683701
45pore complex assembly (GO:0046931)3.22170642
46mitotic sister chromatid cohesion (GO:0007064)3.21162582
47protein localization to chromosome, centromeric region (GO:0071459)3.20100474
48meiotic chromosome segregation (GO:0045132)3.18332646
49regulation of chromosome segregation (GO:0051983)3.17767281
50tRNA aminoacylation for protein translation (GO:0006418)3.14447833
51male meiosis (GO:0007140)3.13418213
52regulation of nuclear cell cycle DNA replication (GO:0033262)3.13119152
53positive regulation of chromosome segregation (GO:0051984)3.11092375
54melanosome organization (GO:0032438)3.10371471
55pigment biosynthetic process (GO:0046148)3.08915488
56amino acid activation (GO:0043038)3.07616921
57tRNA aminoacylation (GO:0043039)3.07616921
58regulation of centriole replication (GO:0046599)3.06866366
59kinetochore organization (GO:0051383)3.05730883
60DNA packaging (GO:0006323)3.04732576
61negative regulation of chromosome segregation (GO:0051985)3.04098014
62transcription from mitochondrial promoter (GO:0006390)3.02726049
63protein localization to kinetochore (GO:0034501)3.02684716
64mitotic spindle checkpoint (GO:0071174)3.02351898
65regulation of DNA-dependent DNA replication (GO:0090329)3.02270180
66formation of translation preinitiation complex (GO:0001731)2.97256974
67DNA synthesis involved in DNA repair (GO:0000731)2.96684921
68spindle checkpoint (GO:0031577)2.96609019
69histone exchange (GO:0043486)2.94717077
70DNA conformation change (GO:0071103)2.93909649
71maturation of SSU-rRNA (GO:0030490)2.93489324
72spliceosomal tri-snRNP complex assembly (GO:0000244)2.93030001
73negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.91437927
74negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.91437927
75negative regulation of mitotic sister chromatid segregation (GO:0033048)2.91437927
76negative regulation of mitotic sister chromatid separation (GO:2000816)2.91437927
77negative regulation of sister chromatid segregation (GO:0033046)2.91437927
78pigment granule organization (GO:0048753)2.91109784
79regulation of double-strand break repair via homologous recombination (GO:0010569)2.87356657
80mitotic spindle assembly checkpoint (GO:0007094)2.85382518
81intra-S DNA damage checkpoint (GO:0031573)2.84812281
82tetrahydrofolate metabolic process (GO:0046653)2.84426157
83anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.84046267
84kinetochore assembly (GO:0051382)2.83138121
85double-strand break repair via nonhomologous end joining (GO:0006303)2.82546324
86non-recombinational repair (GO:0000726)2.82546324
87mitochondrial RNA metabolic process (GO:0000959)2.81856831
88regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.81454419
89spliceosomal snRNP assembly (GO:0000387)2.81447207
90spindle assembly checkpoint (GO:0071173)2.79575443
91proteasome assembly (GO:0043248)2.77862861
92mitotic G2/M transition checkpoint (GO:0044818)2.77638617
93DNA duplex unwinding (GO:0032508)2.76047202
94establishment of chromosome localization (GO:0051303)2.74649156
95ribosome biogenesis (GO:0042254)2.74514118
96microtubule depolymerization (GO:0007019)2.74368416
97maturation of 5.8S rRNA (GO:0000460)2.71578113
98L-serine metabolic process (GO:0006563)2.71104368
99DNA replication-independent nucleosome organization (GO:0034724)2.70996811
100negative regulation of retinoic acid receptor signaling pathway (GO:0048387)10.7297802

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.12557731
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.82286816
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.67702282
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.81775128
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.73011948
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.53321500
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.22473978
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.08858657
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.02534224
10GABP_17652178_ChIP-ChIP_JURKAT_Human3.02311376
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.98948093
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.97809530
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.81147196
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.80441205
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.61655012
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.55689994
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.55503321
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.38780564
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.37116884
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.36566231
21THAP11_20581084_ChIP-Seq_MESCs_Mouse2.25197511
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.24245706
23MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.22211461
24AR_21909140_ChIP-Seq_LNCAP_Human2.21340014
25PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.16739799
26FOXP3_21729870_ChIP-Seq_TREG_Human2.11598168
27SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.09732164
28E2F1_21310950_ChIP-Seq_MCF-7_Human2.06783463
29DCP1A_22483619_ChIP-Seq_HELA_Human2.03871739
30VDR_23849224_ChIP-Seq_CD4+_Human1.99483521
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.95335049
32NELFA_20434984_ChIP-Seq_ESCs_Mouse1.92106291
33GABP_19822575_ChIP-Seq_HepG2_Human1.91759146
34XRN2_22483619_ChIP-Seq_HELA_Human1.91070379
35MYCN_18555785_ChIP-Seq_MESCs_Mouse1.88413523
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.82784784
37KDM5A_27292631_Chip-Seq_BREAST_Human1.82121377
38YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80371023
39KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.79168275
40TTF2_22483619_ChIP-Seq_HELA_Human1.76576110
41ELK1_19687146_ChIP-ChIP_HELA_Human1.75139982
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.71960289
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.69743794
44E2F1_18555785_ChIP-Seq_MESCs_Mouse1.69310514
45ESR1_15608294_ChIP-ChIP_MCF-7_Human1.66088487
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.62698134
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.56547718
48PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.47682537
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.42513618
50PADI4_21655091_ChIP-ChIP_MCF-7_Human1.36594347
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.33778494
52CIITA_25753668_ChIP-Seq_RAJI_Human1.33441071
53E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.33145761
54NANOG_18555785_ChIP-Seq_MESCs_Mouse1.32582525
55MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.31402923
56CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.30256361
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.28882721
58TFEB_21752829_ChIP-Seq_HELA_Human1.28313977
59ZFX_18555785_ChIP-Seq_MESCs_Mouse1.28301237
60CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25991004
61GATA1_22025678_ChIP-Seq_K562_Human1.23471432
62CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.23265133
63BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.20590075
64MYC_22102868_ChIP-Seq_BL_Human1.19205257
65CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.18917235
66ERG_20887958_ChIP-Seq_HPC-7_Mouse1.16848786
67MYC_18940864_ChIP-ChIP_HL60_Human1.11959531
68ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.07798447
69TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.07337079
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06446401
71CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.04657176
72CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95792616
73NCOR1_26117541_ChIP-Seq_K562_Human0.95029445
74KLF4_18555785_ChIP-Seq_MESCs_Mouse0.91268402
75POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.90197717
76PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.89283125
77CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.88990476
78FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.87965616
79DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.87739811
80STAT3_1855785_ChIP-Seq_MESCs_Mouse0.85256202
81GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.82210942
82VDR_22108803_ChIP-Seq_LS180_Human0.79162532
83SALL1_21062744_ChIP-ChIP_HESCs_Human0.77156704
84ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.77113140
85SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.76886638
86CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.76448587
87GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.74175452
88CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.73906847
89RBPJ_22232070_ChIP-Seq_NCS_Mouse0.71842405
90HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.71674406
91ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.69392950
92GATA6_21074721_ChIP-Seq_CACO-2_Human0.68783228
93RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.68030469
94POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.67639802
95RBPJ_21746931_ChIP-Seq_IB4_Human0.67028067
96PHF8_20622853_ChIP-Seq_HELA_Human0.63558278
97EGR1_19374776_ChIP-ChIP_THP-1_Human0.62477655
98CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.61528028
99TBX5_21415370_ChIP-Seq_HL-1_Mouse0.58922170
100SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.57667290

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation6.32960334
2MP0005171_absent_coat_pigmentation4.60895611
3MP0010094_abnormal_chromosome_stability3.87156666
4MP0003136_yellow_coat_color3.85879081
5MP0003806_abnormal_nucleotide_metabolis3.74770069
6MP0003693_abnormal_embryo_hatching3.52925396
7MP0003111_abnormal_nucleus_morphology3.50204181
8MP0008058_abnormal_DNA_repair3.35805608
9MP0004957_abnormal_blastocyst_morpholog3.23798179
10MP0008057_abnormal_DNA_replication3.20128112
11MP0003077_abnormal_cell_cycle3.15241712
12MP0000015_abnormal_ear_pigmentation3.14923615
13MP0005075_abnormal_melanosome_morpholog3.05430400
14MP0002102_abnormal_ear_morphology3.01811711
15MP0005408_hypopigmentation2.60656757
16MP0002938_white_spotting2.47266495
17MP0004147_increased_porphyrin_level2.37837160
18MP0005451_abnormal_body_composition2.34175261
19MP0003718_maternal_effect2.33656116
20MP0003878_abnormal_ear_physiology2.26682987
21MP0005377_hearing/vestibular/ear_phenot2.26682987
22MP0002095_abnormal_skin_pigmentation2.20227861
23MP0008932_abnormal_embryonic_tissue2.11511456
24MP0000371_diluted_coat_color2.01462972
25MP0000350_abnormal_cell_proliferation1.61059859
26MP0001545_abnormal_hematopoietic_system1.54278961
27MP0005397_hematopoietic_system_phenotyp1.54278961
28MP0004381_abnormal_hair_follicle1.52066073
29MP0003186_abnormal_redox_activity1.50882235
30MP0003786_premature_aging1.50617400
31MP0004233_abnormal_muscle_weight1.43054963
32MP0001697_abnormal_embryo_size1.39322653
33MP0001324_abnormal_eye_pigmentation1.39296536
34MP0010030_abnormal_orbit_morphology1.36067422
35MP0003646_muscle_fatigue1.33136129
36MP0005174_abnormal_tail_pigmentation1.31907580
37MP0006036_abnormal_mitochondrial_physio1.28613707
38MP0002210_abnormal_sex_determination1.27717588
39MP0002075_abnormal_coat/hair_pigmentati1.25725196
40MP0001672_abnormal_embryogenesis/_devel1.24976759
41MP0005380_embryogenesis_phenotype1.24976759
42MP0001929_abnormal_gametogenesis1.23980166
43MP0002877_abnormal_melanocyte_morpholog1.23777616
44MP0003221_abnormal_cardiomyocyte_apopto1.22028007
45MP0001730_embryonic_growth_arrest1.21713324
46MP0003567_abnormal_fetal_cardiomyocyte1.20551911
47MP0002396_abnormal_hematopoietic_system1.20506576
48MP0008007_abnormal_cellular_replicative1.19971722
49MP0004133_heterotaxia1.16607689
50MP0009697_abnormal_copulation1.16602814
51MP0008995_early_reproductive_senescence1.14511855
52MP0002080_prenatal_lethality1.09535371
53MP0001986_abnormal_taste_sensitivity1.06509026
54MP0000313_abnormal_cell_death1.04563409
55MP0000647_abnormal_sebaceous_gland1.04109797
56MP0003984_embryonic_growth_retardation1.01583889
57MP0006292_abnormal_olfactory_placode0.99474766
58MP0004808_abnormal_hematopoietic_stem0.99302542
59MP0002088_abnormal_embryonic_growth/wei0.98926622
60MP0001186_pigmentation_phenotype0.98235346
61MP0000678_abnormal_parathyroid_gland0.94655315
62MP0010307_abnormal_tumor_latency0.94533938
63MP0002084_abnormal_developmental_patter0.87032708
64MP0002085_abnormal_embryonic_tissue0.86485520
65MP0000653_abnormal_sex_gland0.84251769
66MP0001145_abnormal_male_reproductive0.83661400
67MP0003699_abnormal_female_reproductive0.83497313
68MP0003698_abnormal_male_reproductive0.81968155
69MP0006035_abnormal_mitochondrial_morpho0.79758579
70MP0002019_abnormal_tumor_incidence0.78066364
71MP0003890_abnormal_embryonic-extraembry0.77194154
72MP0008877_abnormal_DNA_methylation0.71533701
73MP0002269_muscular_atrophy0.71185422
74MP0004197_abnormal_fetal_growth/weight/0.68864328
75MP0003137_abnormal_impulse_conducting0.68440708
76MP0002086_abnormal_extraembryonic_tissu0.68438360
77MP0005423_abnormal_somatic_nervous0.67702467
78MP0001119_abnormal_female_reproductive0.67430343
79MP0009840_abnormal_foam_cell0.66712392
80MP0005197_abnormal_uvea_morphology0.66679283
81MP0001764_abnormal_homeostasis0.65946468
82MP0004885_abnormal_endolymph0.65602066
83MP0002161_abnormal_fertility/fecundity0.64945457
84MP0000569_abnormal_digit_pigmentation0.64905295
85MP0005266_abnormal_metabolism0.58197564
86MP0002090_abnormal_vision0.57977759
87MP0005253_abnormal_eye_physiology0.57615390
88MP0000358_abnormal_cell_content/0.55195394
89MP0005410_abnormal_fertilization0.54626626
90MP0008789_abnormal_olfactory_epithelium0.54016633
91MP0001293_anophthalmia0.53528203
92MP0000631_abnormal_neuroendocrine_gland0.50688345
93MP0003943_abnormal_hepatobiliary_system0.50166639
94MP0002092_abnormal_eye_morphology0.49300394
95MP0000703_abnormal_thymus_morphology0.47427588
96MP0003950_abnormal_plasma_membrane0.47050515
97MP0005391_vision/eye_phenotype0.45960834
98MP0005394_taste/olfaction_phenotype0.43129891
99MP0005499_abnormal_olfactory_system0.43129891
100MP0005384_cellular_phenotype0.41786514

Predicted human phenotypes

RankGene SetZ-score
1Neoplasm of the adrenal cortex (HP:0100641)6.00658422
2Iris hypopigmentation (HP:0007730)4.66892967
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.42245755
4Ocular albinism (HP:0001107)4.21805216
5Hypoplasia of the fovea (HP:0007750)4.10939493
6Aplasia/Hypoplasia of the fovea (HP:0008060)4.10939493
7Patchy hypopigmentation of hair (HP:0011365)4.08449613
8Chromsome breakage (HP:0040012)4.00933499
9White forelock (HP:0002211)3.96815900
10Neoplasm of the adrenal gland (HP:0100631)3.86879715
11Birth length less than 3rd percentile (HP:0003561)3.81914377
12Anterior segment dysgenesis (HP:0007700)3.78653055
13Abnormality of the fovea (HP:0000493)3.66739153
14Abnormal gallbladder physiology (HP:0012438)3.60437005
15Cholecystitis (HP:0001082)3.60437005
16Aplasia/Hypoplasia of the macula (HP:0008059)3.49230050
17Hypoplasia of the iris (HP:0007676)3.25825877
18Aplasia/Hypoplasia affecting the retina (HP:0008061)3.21145083
19Abnormal auditory evoked potentials (HP:0006958)3.16172065
20Freckling (HP:0001480)3.15289938
21Upper limb muscle weakness (HP:0003484)3.04897691
22Cutaneous melanoma (HP:0012056)3.00505916
23Aplasia/Hypoplasia of the uvula (HP:0010293)2.99971550
24Albinism (HP:0001022)2.99393056
25Small intestinal stenosis (HP:0012848)2.98592923
26Duodenal stenosis (HP:0100867)2.98592923
27Abnormality of chromosome stability (HP:0003220)2.88995733
28Acute necrotizing encephalopathy (HP:0006965)2.84370446
29Melanoma (HP:0002861)2.82974598
30Abnormality of the preputium (HP:0100587)2.77966041
31Meckel diverticulum (HP:0002245)2.71215117
32Acute encephalopathy (HP:0006846)2.69639620
33Abnormality of the ileum (HP:0001549)2.67934760
34Cerebral hypomyelination (HP:0006808)2.62582463
35Homocystinuria (HP:0002156)2.60097024
36Abnormality of homocysteine metabolism (HP:0010919)2.60097024
37Abnormal mitochondria in muscle tissue (HP:0008316)2.58364239
38Premature ovarian failure (HP:0008209)2.57338211
39Duplicated collecting system (HP:0000081)2.47812106
40Neoplasm of the colon (HP:0100273)2.46560035
41Abnormality of the duodenum (HP:0002246)2.43520484
42Male infertility (HP:0003251)2.43490868
43Abnormality of the heme biosynthetic pathway (HP:0010472)2.42399030
44Truncus arteriosus (HP:0001660)2.41437914
45Reticulocytopenia (HP:0001896)2.37421006
46Hyperthyroidism (HP:0000836)2.33514306
47Progressive macrocephaly (HP:0004481)2.33254890
48Premature graying of hair (HP:0002216)2.32149621
49Generalized hypopigmentation (HP:0007513)2.30273854
50Increased CSF lactate (HP:0002490)2.27291110
51Myelodysplasia (HP:0002863)2.26375754
52Abnormality of the renal collecting system (HP:0004742)2.23896514
53Abnormality of DNA repair (HP:0003254)2.23495920
54Degeneration of anterior horn cells (HP:0002398)2.19827582
55Abnormality of the anterior horn cell (HP:0006802)2.19827582
56Sloping forehead (HP:0000340)2.17767407
57Abnormal lung lobation (HP:0002101)2.15309165
58Blue irides (HP:0000635)2.13651915
59Abnormal number of incisors (HP:0011064)2.13113305
60Hypopigmentation of the fundus (HP:0007894)2.12420686
61Long clavicles (HP:0000890)2.09618819
62Mitochondrial inheritance (HP:0001427)2.05607443
63Ependymoma (HP:0002888)2.01989681
64Hypoplastic pelvis (HP:0008839)1.99405192
65Squamous cell carcinoma (HP:0002860)1.98544018
66CNS hypomyelination (HP:0003429)1.98239731
67Abnormality of glycolysis (HP:0004366)1.97964951
68Abnormality of the carotid arteries (HP:0005344)1.97963980
69Hypergonadotropic hypogonadism (HP:0000815)1.96717692
70Microvesicular hepatic steatosis (HP:0001414)1.96531910
71Cerebral edema (HP:0002181)1.95262568
72Megalocornea (HP:0000485)1.90103677
73Intestinal atresia (HP:0011100)1.88387182
74Increased serum lactate (HP:0002151)1.88246447
75Horseshoe kidney (HP:0000085)1.87890195
76Abnormality of reticulocytes (HP:0004312)1.87883904
77Absent thumb (HP:0009777)1.87780780
78Poor head control (HP:0002421)1.87389696
79Nephroblastoma (Wilms tumor) (HP:0002667)1.87240950
80Astigmatism (HP:0000483)1.82873124
81Increased nuchal translucency (HP:0010880)1.81534481
82Abnormal large intestine physiology (HP:0012700)1.81379529
83Anal stenosis (HP:0002025)1.80815478
84Aplasia/Hypoplasia of the earlobes (HP:0009906)1.80240891
85Neoplasm of the pancreas (HP:0002894)1.76460443
86Pallor (HP:0000980)1.76031372
87Anal atresia (HP:0002023)1.76019095
88Bowel incontinence (HP:0002607)1.75781725
89Increased serum pyruvate (HP:0003542)1.75729528
90Abnormality of the pons (HP:0007361)1.75198559
91Hypoplasia of the pons (HP:0012110)1.74523684
92Increased hepatocellular lipid droplets (HP:0006565)1.72966350
93Abnormality of sulfur amino acid metabolism (HP:0004339)1.72814445
94Cafe-au-lait spot (HP:0000957)1.72678395
95Ectopic kidney (HP:0000086)1.71582820
96Entropion (HP:0000621)1.71225406
97Seborrheic dermatitis (HP:0001051)1.70934638
98Posterior embryotoxon (HP:0000627)1.69746254
99Hypoparathyroidism (HP:0000829)1.69400778
100Embryonal renal neoplasm (HP:0011794)1.68749716

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE16.57894903
2BUB13.40955565
3SRPK13.40813459
4TTK3.36993112
5PLK43.29411787
6EIF2AK12.97313392
7CDC72.43735465
8BMPR22.32644429
9BRSK22.25543250
10PBK2.14301789
11ATR2.11022590
12PLK12.10215339
13EIF2AK32.09868816
14MARK32.01528253
15PDK22.00862462
16BRSK11.92115406
17CHEK21.88657341
18PIM11.83571286
19NEK11.80614188
20PLK31.74014554
21CLK11.73899067
22CCNB11.55810342
23MAP3K101.53238786
24MST41.52599406
25CDK71.52056735
26NEK21.49345527
27NME11.47472800
28TRIM281.46111083
29ZAK1.43149832
30DAPK31.31283805
31PLK21.26089470
32CHEK11.23541741
33STK101.19986478
34ATM1.13035948
35CDK31.10536936
36AURKB1.10183467
37TAOK31.08519833
38STK31.08025039
39AKT21.07133265
40LATS11.04649937
41MAP3K80.99634906
42NME20.95764786
43ERBB30.93008889
44STK160.89979533
45ACVR1B0.89927420
46CDK20.86972688
47STK40.82929397
48CDK40.82826497
49BMPR1B0.81993635
50ERN10.80426849
51AURKA0.80327642
52EIF2AK20.79753461
53CDK10.77912493
54NEK60.76713589
55RAF10.76184712
56MAPKAPK20.74929720
57ERBB40.74890890
58CSNK2A10.74205911
59TSSK60.73893317
60RPS6KB10.72799327
61PNCK0.72702728
62CDK80.71863295
63MKNK10.66388459
64KSR10.66333273
65LATS20.65375867
66PRKCI0.57685347
67CSNK2A20.57013172
68CSNK1G10.53860847
69BMX0.53235883
70KSR20.52803334
71PAK10.51775083
72WNK30.48656166
73LRRK20.47177087
74VRK20.44146560
75PRKDC0.43869162
76CSNK1D0.43415570
77TYRO30.43227145
78CSNK1G30.40898887
79EEF2K0.40281990
80CSNK1A10.39772829
81GSK3B0.39758785
82PAK40.38139775
83MKNK20.36623567
84CSNK1G20.34895850
85NTRK30.33686185
86AKT10.33636941
87WNK40.33195905
88PIM20.32816174
89CSNK1E0.32508540
90BRAF0.32292014
91KDR0.31128898
92CDK60.30796449
93RIPK40.28076153
94RPS6KB20.28034007
95GSK3A0.27650667
96MAPK140.27233510
97PINK10.26571171
98CSNK1A1L0.26083252
99STK390.24030256
100VRK10.22964236

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.51560297
2Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.78283777
3Mismatch repair_Homo sapiens_hsa034303.56666383
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.21837473
5Homologous recombination_Homo sapiens_hsa034403.15744933
6One carbon pool by folate_Homo sapiens_hsa006703.11513507
7Cell cycle_Homo sapiens_hsa041103.06787255
8Non-homologous end-joining_Homo sapiens_hsa034502.97736429
9Proteasome_Homo sapiens_hsa030502.60804888
10Fanconi anemia pathway_Homo sapiens_hsa034602.60696537
11Base excision repair_Homo sapiens_hsa034102.43387332
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.42677432
13RNA transport_Homo sapiens_hsa030132.42066941
14Spliceosome_Homo sapiens_hsa030402.35901204
15Cyanoamino acid metabolism_Homo sapiens_hsa004602.31070117
16Nucleotide excision repair_Homo sapiens_hsa034202.29760865
17Basal transcription factors_Homo sapiens_hsa030222.18277834
18Ribosome_Homo sapiens_hsa030102.04219449
19RNA polymerase_Homo sapiens_hsa030202.03275740
20Selenocompound metabolism_Homo sapiens_hsa004501.73195281
21Protein export_Homo sapiens_hsa030601.72732741
22p53 signaling pathway_Homo sapiens_hsa041151.66107955
23Pyrimidine metabolism_Homo sapiens_hsa002401.64982554
24mRNA surveillance pathway_Homo sapiens_hsa030151.54116749
25Steroid biosynthesis_Homo sapiens_hsa001001.51369948
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.48237043
27Parkinsons disease_Homo sapiens_hsa050121.46070127
28RNA degradation_Homo sapiens_hsa030181.43993262
29Oxidative phosphorylation_Homo sapiens_hsa001901.43049809
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.40199483
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.37458339
32Oocyte meiosis_Homo sapiens_hsa041141.31305037
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.27785196
34Pyruvate metabolism_Homo sapiens_hsa006201.16364807
35Bladder cancer_Homo sapiens_hsa052191.13390021
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.13348265
37Biosynthesis of amino acids_Homo sapiens_hsa012301.12764766
38Tyrosine metabolism_Homo sapiens_hsa003501.11298260
39Huntingtons disease_Homo sapiens_hsa050161.05206670
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.99702712
41Purine metabolism_Homo sapiens_hsa002300.95698092
42Carbon metabolism_Homo sapiens_hsa012000.90602758
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81529016
44Folate biosynthesis_Homo sapiens_hsa007900.80978814
45Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.80904369
46Fatty acid elongation_Homo sapiens_hsa000620.77834357
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.77435389
48Collecting duct acid secretion_Homo sapiens_hsa049660.73844440
49Glutathione metabolism_Homo sapiens_hsa004800.73761253
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72940446
51Prostate cancer_Homo sapiens_hsa052150.67255364
52Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65739685
53Melanoma_Homo sapiens_hsa052180.64491392
54Vitamin B6 metabolism_Homo sapiens_hsa007500.64054883
55Epstein-Barr virus infection_Homo sapiens_hsa051690.64007344
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.61514265
57Propanoate metabolism_Homo sapiens_hsa006400.61352079
58Sulfur relay system_Homo sapiens_hsa041220.60716424
59Pentose phosphate pathway_Homo sapiens_hsa000300.57550365
60Arginine and proline metabolism_Homo sapiens_hsa003300.57287196
61Chronic myeloid leukemia_Homo sapiens_hsa052200.56127508
62Lysine degradation_Homo sapiens_hsa003100.54821624
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52484446
64Alzheimers disease_Homo sapiens_hsa050100.52222127
65Metabolic pathways_Homo sapiens_hsa011000.50882437
66Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.46879913
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44449794
68Viral carcinogenesis_Homo sapiens_hsa052030.44287937
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43982387
70Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.41024866
71Thyroid cancer_Homo sapiens_hsa052160.40945479
72Glioma_Homo sapiens_hsa052140.40630094
73MicroRNAs in cancer_Homo sapiens_hsa052060.39491041
74N-Glycan biosynthesis_Homo sapiens_hsa005100.39255123
75Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.31561494
76Vibrio cholerae infection_Homo sapiens_hsa051100.28659724
77Arginine biosynthesis_Homo sapiens_hsa002200.27620374
78Fatty acid metabolism_Homo sapiens_hsa012120.26278364
79Fructose and mannose metabolism_Homo sapiens_hsa000510.26200934
80Olfactory transduction_Homo sapiens_hsa047400.25785478
81Drug metabolism - other enzymes_Homo sapiens_hsa009830.21586052
82Regulation of autophagy_Homo sapiens_hsa041400.19256285
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.19210504
84Butanoate metabolism_Homo sapiens_hsa006500.18131825
85HTLV-I infection_Homo sapiens_hsa051660.17480449
86ABC transporters_Homo sapiens_hsa020100.17277748
87beta-Alanine metabolism_Homo sapiens_hsa004100.15620482
88Herpes simplex infection_Homo sapiens_hsa051680.14485594
89TGF-beta signaling pathway_Homo sapiens_hsa043500.13909298
90Peroxisome_Homo sapiens_hsa041460.13822491
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.12860073
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.12263989
93Taste transduction_Homo sapiens_hsa047420.12259809
94Small cell lung cancer_Homo sapiens_hsa052220.11952375
95Hepatitis B_Homo sapiens_hsa051610.10223843
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.07881666
97Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.07877653
98Inositol phosphate metabolism_Homo sapiens_hsa005620.06401887
99Synaptic vesicle cycle_Homo sapiens_hsa047210.04871221
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.04651710

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