SSR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein (alpha-SSR or SSR1) and a 22-kD glycoprotein (beta-SSR or SSR2). The human beta-signal sequence receptor gene (SSR2) maps to chromosome bands 1q21-q23. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)7.41663715
2viral transcription (GO:0019083)6.55517827
3maintenance of protein location in nucleus (GO:0051457)6.41866710
4* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.41692565
5* cotranslational protein targeting to membrane (GO:0006613)6.31256425
6* protein targeting to ER (GO:0045047)6.27428521
7regulation of nuclear cell cycle DNA replication (GO:0033262)6.24120805
8somite rostral/caudal axis specification (GO:0032525)6.23638001
9protein localization to kinetochore (GO:0034501)6.22242490
10translational termination (GO:0006415)6.21809786
11regulation of mammary gland epithelial cell proliferation (GO:0033599)6.17662746
12negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)6.10662982
13ribosomal small subunit assembly (GO:0000028)6.04757014
14* protein localization to endoplasmic reticulum (GO:0070972)5.97919332
15* establishment of protein localization to endoplasmic reticulum (GO:0072599)5.97511133
16ribosomal small subunit biogenesis (GO:0042274)5.88204681
17regulation of response to osmotic stress (GO:0047484)5.79626916
18regulation of telomere maintenance via telomerase (GO:0032210)5.78846565
19negative regulation of telomerase activity (GO:0051974)5.66281855
20negative regulation of epidermis development (GO:0045683)5.62844425
21negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)5.59518230
22negative regulation of cell cycle G2/M phase transition (GO:1902750)5.56815379
23regulation of MHC class I biosynthetic process (GO:0045343)5.48511614
24translational elongation (GO:0006414)5.45358305
25rRNA transcription (GO:0009303)5.30570039
26histone H4-K12 acetylation (GO:0043983)5.27861945
27viral life cycle (GO:0019058)5.18687253
28muscle organ morphogenesis (GO:0048644)5.14390340
29histone H4-K5 acetylation (GO:0043981)5.07781156
30histone H4-K8 acetylation (GO:0043982)5.07781156
31COPI coating of Golgi vesicle (GO:0048205)5.05979377
32Golgi transport vesicle coating (GO:0048200)5.05979377
33mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.00541003
34mitotic sister chromatid segregation (GO:0000070)4.89687764
35cytidine deamination (GO:0009972)4.87933714
36cytidine metabolic process (GO:0046087)4.87933714
37cytidine catabolic process (GO:0006216)4.87933714
38nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.85049596
39notochord development (GO:0030903)4.79485498
40rRNA methylation (GO:0031167)4.73980583
41cellular protein complex disassembly (GO:0043624)4.72823832
42regulation of apoptotic process involved in morphogenesis (GO:1902337)4.69400731
43translational initiation (GO:0006413)4.68387636
44nucleoside transmembrane transport (GO:1901642)4.60136872
45regulation of translation in response to stress (GO:0043555)4.58032754
46energy coupled proton transport, down electrochemical gradient (GO:0015985)4.55640231
47ATP synthesis coupled proton transport (GO:0015986)4.55640231
48quinone metabolic process (GO:1901661)4.54715168
49protein localization to chromosome, centromeric region (GO:0071459)4.54417161
50positive regulation of DNA-dependent DNA replication (GO:2000105)4.54224253
51regulation of cilium movement (GO:0003352)4.51088151
52negative regulation of epidermal cell differentiation (GO:0045605)4.49688362
53DNA replication-dependent nucleosome organization (GO:0034723)4.47078532
54DNA replication-dependent nucleosome assembly (GO:0006335)4.47078532
55rRNA modification (GO:0000154)4.46150811
56DNA replication checkpoint (GO:0000076)4.45713211
57coenzyme catabolic process (GO:0009109)4.45234097
58hormone catabolic process (GO:0042447)4.44552282
59negative regulation of telomere maintenance (GO:0032205)4.44191495
60response to dietary excess (GO:0002021)4.41701161
61cullin deneddylation (GO:0010388)4.41136501
62* protein targeting to membrane (GO:0006612)4.37263036
63maturation of SSU-rRNA (GO:0030490)4.35819699
64phenol-containing compound catabolic process (GO:0019336)4.34957626
65heterochromatin organization (GO:0070828)4.33145844
66ribosomal large subunit biogenesis (GO:0042273)4.30328862
67primitive streak formation (GO:0090009)4.29872820
68* translation (GO:0006412)4.29147311
69GDP-mannose metabolic process (GO:0019673)4.22719659
70protein maturation by protein folding (GO:0022417)4.22438488
71maintenance of protein localization in organelle (GO:0072595)4.16633561
72negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.14572054
73branching involved in mammary gland duct morphogenesis (GO:0060444)4.07627278
74sister chromatid segregation (GO:0000819)4.03228205
75interferon-gamma production (GO:0032609)4.00301464
76protein complex disassembly (GO:0043241)3.98541152
77chromatin assembly (GO:0031497)3.95411932
78regulation of cellular amino acid metabolic process (GO:0006521)3.93902201
79DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.93351188
80protein deneddylation (GO:0000338)3.91972544
81antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.91180618
82cell fate commitment involved in formation of primary germ layer (GO:0060795)3.88650578
83positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.86134047
84signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.83334876
85intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.83334876
86negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.82761106
87negative regulation of ligase activity (GO:0051352)3.82761106
88signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.79216026
89signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.79216026
90signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.79216026
91macromolecular complex disassembly (GO:0032984)3.77456407
92nuclear pore complex assembly (GO:0051292)3.76423344
93intestinal epithelial cell development (GO:0060576)3.76081736
94antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.70720248
95signal transduction involved in DNA integrity checkpoint (GO:0072401)3.70285676
96signal transduction involved in DNA damage checkpoint (GO:0072422)3.70285676
97formation of translation preinitiation complex (GO:0001731)3.70214188
98regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.66137188
99signal transduction involved in cell cycle checkpoint (GO:0072395)3.62192431
100histone H4-K16 acetylation (GO:0043984)3.61087669
101cellular modified amino acid catabolic process (GO:0042219)3.59881249
102establishment of protein localization to mitochondrial membrane (GO:0090151)3.57948033
103regulation of telomerase activity (GO:0051972)3.57018621
104proteasome assembly (GO:0043248)3.53308402
105ribosome biogenesis (GO:0042254)3.51679366
106positive regulation of protein deacetylation (GO:0090312)3.48316428
107cardiovascular system development (GO:0072358)3.48282747
108intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.47605484
109anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.45597380
110maternal placenta development (GO:0001893)3.45469225
111maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.45169816
112pyrimidine ribonucleoside catabolic process (GO:0046133)3.45012195
113nucleoside transport (GO:0015858)3.44255916
114respiratory electron transport chain (GO:0022904)3.41142628
115nuclear pore organization (GO:0006999)3.39559120
116chaperone-mediated protein transport (GO:0072321)3.36250477
117electron transport chain (GO:0022900)3.36234669
118mitochondrion distribution (GO:0048311)3.35912035
119protein retention in ER lumen (GO:0006621)3.35135035
120ribonucleoprotein complex biogenesis (GO:0022613)3.34808603
121nuclear-transcribed mRNA catabolic process (GO:0000956)3.34527673
122regulation of telomere maintenance (GO:0032204)3.33258519
123bone trabecula formation (GO:0060346)3.30774376
124intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)3.30559732
125viral protein processing (GO:0019082)3.28751870
126pseudouridine synthesis (GO:0001522)3.28193284
127positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.27579730
128transcription from mitochondrial promoter (GO:0006390)3.26702383
129antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.26431607
130mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.25996107
131RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.24602249
132tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.24602249
133DNA damage response, detection of DNA damage (GO:0042769)3.24565553
134trophectodermal cell differentiation (GO:0001829)3.23393272
135retinoic acid receptor signaling pathway (GO:0048384)3.19064245
136regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.18104790
137mRNA catabolic process (GO:0006402)3.16455568
138regulation of gene silencing by RNA (GO:0060966)3.15257659
139regulation of posttranscriptional gene silencing (GO:0060147)3.15257659
140regulation of gene silencing by miRNA (GO:0060964)3.15257659
141positive regulation of ligase activity (GO:0051351)3.14761188
142epoxygenase P450 pathway (GO:0019373)3.13111475
143* establishment of protein localization to membrane (GO:0090150)3.13078800
144positive regulation of cell cycle arrest (GO:0071158)3.12256541
145RNA stabilization (GO:0043489)3.11523564
146mRNA stabilization (GO:0048255)3.11523564
147vitamin A metabolic process (GO:0006776)3.09587080
148pteridine-containing compound biosynthetic process (GO:0042559)3.08738845
149nucleotide-sugar biosynthetic process (GO:0009226)3.07340994
150protein targeting to mitochondrion (GO:0006626)3.07126047
151DNA duplex unwinding (GO:0032508)3.06848629
152arachidonic acid secretion (GO:0050482)3.05672877
153icosanoid secretion (GO:0032309)3.05672877
154virion assembly (GO:0019068)3.04565130
155dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.04501086
156regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.03584841
157guanosine-containing compound biosynthetic process (GO:1901070)3.02461317
158DNA geometric change (GO:0032392)3.02331516
159positive regulation of histone deacetylation (GO:0031065)3.01155081
160cellular component biogenesis (GO:0044085)2.98967972
161GTP biosynthetic process (GO:0006183)2.98357517
162microtubule severing (GO:0051013)2.98135339
163regulation of mitochondrial translation (GO:0070129)2.96574598
164pre-miRNA processing (GO:0031054)2.95333120
165regulation of microtubule-based movement (GO:0060632)2.95021627
166cofactor transport (GO:0051181)2.94797187
167signal transduction involved in regulation of gene expression (GO:0023019)2.94651111
168apoptotic DNA fragmentation (GO:0006309)2.93688253
169* protein targeting (GO:0006605)2.91176414
170peptidyl-histidine modification (GO:0018202)2.89945952
171negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.88252892
172establishment of protein localization to mitochondrion (GO:0072655)2.86479608
173regulation of cellular amine metabolic process (GO:0033238)2.85189502
174amyloid precursor protein catabolic process (GO:0042987)2.84694702
175RNA catabolic process (GO:0006401)2.82688518
176transcription elongation from RNA polymerase III promoter (GO:0006385)2.81517218
177termination of RNA polymerase III transcription (GO:0006386)2.81517218
178nucleobase-containing small molecule interconversion (GO:0015949)2.81327166
179regulation of ubiquitin-protein transferase activity (GO:0051438)2.79309964
180mannosylation (GO:0097502)2.79138413
181UTP biosynthetic process (GO:0006228)2.79134161
182base-excision repair, AP site formation (GO:0006285)2.74971827
183DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.71002055
184regulation of ligase activity (GO:0051340)2.70663810
185CTP biosynthetic process (GO:0006241)2.70153901
186CTP metabolic process (GO:0046036)2.70153901
187regulation of cell cycle arrest (GO:0071156)2.69760334
188negative regulation of protein ubiquitination (GO:0031397)2.67970591
189protein localization to mitochondrion (GO:0070585)2.66191121
190deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.61924352
191protein complex biogenesis (GO:0070271)2.61623093
192cell redox homeostasis (GO:0045454)2.61553739
193doxorubicin metabolic process (GO:0044598)11.4539744
194daunorubicin metabolic process (GO:0044597)11.4539744
195polyketide metabolic process (GO:0030638)11.4539744

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF4_18264089_ChIP-ChIP_MESCs_Mouse6.03825622
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse6.03825622
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse6.03825622
4BP1_19119308_ChIP-ChIP_Hs578T_Human5.71752677
5E2F7_22180533_ChIP-Seq_HELA_Human4.68437934
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.63329956
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.68141993
8NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.07244000
9POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.96663412
10TP63_19390658_ChIP-ChIP_HaCaT_Human2.95160128
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.70600110
12SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.66163530
13* SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.50008463
14NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.34130389
15* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.31513456
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.28482746
17* TCF3_18692474_ChIP-Seq_MESCs_Mouse2.22059273
18* TCF3_18692474_ChIP-Seq_MEFs_Mouse2.21907705
19DCP1A_22483619_ChIP-Seq_HELA_Human2.14418096
20ELK1_19687146_ChIP-ChIP_HELA_Human2.07224317
21* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.05972082
22* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.05542736
23SRF_21415370_ChIP-Seq_HL-1_Mouse2.04305746
24NANOG_18358816_ChIP-ChIP_MESCs_Mouse2.01881162
25THAP11_20581084_ChIP-Seq_MESCs_Mouse2.01102055
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.99769746
27CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.94924975
28MYC_19079543_ChIP-ChIP_MESCs_Mouse1.90631762
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.90072125
30* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.88181639
31STAT3_1855785_ChIP-Seq_MESCs_Mouse1.88110172
32* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.84940715
33KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.84368027
34CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.84267083
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.83165808
36FOXM1_23109430_ChIP-Seq_U2OS_Human1.81591078
37ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.78752405
38* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.78659822
39* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.78651542
40KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.77783792
41POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.77235142
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.77149605
43NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.75541810
44CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.75479775
45E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.74483000
46NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.74349278
47IRF1_19129219_ChIP-ChIP_H3396_Human1.73048575
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.69872169
49MYC_18358816_ChIP-ChIP_MESCs_Mouse1.68300372
50CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.68248143
51ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.67019063
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.66956543
53HIF1A_21447827_ChIP-Seq_MCF-7_Human1.62772719
54CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.60395044
55MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.59580396
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.55404540
57PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.53960738
58POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.46203794
59* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.45192959
60EST1_17652178_ChIP-ChIP_JURKAT_Human1.44837330
61MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.43457507
62* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.41897653
63SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.41638170
64TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39298405
65TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.38122995
66FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.37812539
67RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36769712
68DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.35456087
69* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.35228155
70* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.34058650
71ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.32733329
72* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.31354412
73MYC_22102868_ChIP-Seq_BL_Human1.30549030
74HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.28902888
75ERG_20887958_ChIP-Seq_HPC-7_Mouse1.28311575
76* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.28229583
77E2F1_17053090_ChIP-ChIP_MCF-7_Human1.27365340
78SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.26252527
79CTCF_18555785_ChIP-Seq_MESCs_Mouse1.25885813
80* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.25400549
81SRY_22984422_ChIP-ChIP_TESTIS_Rat1.24779361
82SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.24673963
83RARG_19884340_ChIP-ChIP_MEFs_Mouse1.24110688
84* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.21335137
85TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.19896620
86* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.19361101
87* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.19131189
88NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.18939384
89* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.17707113
90ZNF263_19887448_ChIP-Seq_K562_Human1.14409883
91NOTCH1_21737748_ChIP-Seq_TLL_Human1.14042263
92* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.13228195
93TET1_21451524_ChIP-Seq_MESCs_Mouse1.12683045
94ZFP281_18757296_ChIP-ChIP_E14_Mouse1.12211666
95ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.10097517
96NANOG_16153702_ChIP-ChIP_HESCs_Human1.07952277
97HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.06929721
98NANOG_21062744_ChIP-ChIP_HESCs_Human1.06882398
99YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06698917
100FOXP3_21729870_ChIP-Seq_TREG_Human1.06559060
101* NANOG_16518401_ChIP-PET_MESCs_Mouse1.05656186
102CIITA_25753668_ChIP-Seq_RAJI_Human1.04724375
103CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.04657658
104DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.04443870
105* ELK3_25401928_ChIP-Seq_HUVEC_Human1.03801365
106* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02458408
107SPI1_23547873_ChIP-Seq_NB4_Human1.00670714
108PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.00177991
109* ETS1_20019798_ChIP-Seq_JURKAT_Human0.99573062
110TRIM28_21343339_ChIP-Seq_HEK293_Human0.99041918
111ELF5_23300383_ChIP-Seq_T47D_Human0.98109663
112ZFP281_27345836_Chip-Seq_ESCs_Mouse0.97759433
113VDR_21846776_ChIP-Seq_THP-1_Human0.97646872
114CDX2_20551321_ChIP-Seq_CACO-2_Human0.96985510
115PADI4_21655091_ChIP-ChIP_MCF-7_Human0.96176747
116* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.93190280
117NELFA_20434984_ChIP-Seq_ESCs_Mouse0.93031341
118KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.92382328
119NCOR1_26117541_ChIP-Seq_K562_Human0.91349346
120* GABP_17652178_ChIP-ChIP_JURKAT_Human0.91172052
121KLF4_18555785_ChIP-Seq_MESCs_Mouse0.90975696
122* XRN2_22483619_ChIP-Seq_HELA_Human0.90073989
123FOXP1_21924763_ChIP-Seq_HESCs_Human0.89944293
124SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.89457299
125* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.88663277
126TP53_22127205_ChIP-Seq_IMR90_Human0.87552765
127IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.87249792
128RACK7_27058665_Chip-Seq_MCF-7_Human0.86333938
129SOX17_20123909_ChIP-Seq_XEN_Mouse0.85964056
130GABP_19822575_ChIP-Seq_HepG2_Human0.85269029
131MYC_18940864_ChIP-ChIP_HL60_Human0.85126698
132ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.84567779
133SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.83535418
134PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.82979814
135MYCN_18555785_ChIP-Seq_MESCs_Mouse0.82141245
136ZFX_18555785_ChIP-Seq_MESCs_Mouse0.80441624
137ELK1_22589737_ChIP-Seq_MCF10A_Human0.80213529
138YY1_22570637_ChIP-Seq_MALME-3M_Human0.80012269
139POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.79986473
140* KAP1_27257070_Chip-Seq_ESCs_Mouse0.78290974
141EGR1_19374776_ChIP-ChIP_THP-1_Human0.76879696
142TTF2_22483619_ChIP-Seq_HELA_Human0.76391448
143PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.75805041
144* KDM5A_27292631_Chip-Seq_BREAST_Human0.75141519
145AR_21909140_ChIP-Seq_LNCAP_Human0.74960333
146HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.74860524
147TFEB_21752829_ChIP-Seq_HELA_Human0.73275585
148CTCF_21964334_Chip-Seq_Bcells_Human0.71731497
149ELF1_20517297_ChIP-Seq_JURKAT_Human0.71530296
150VDR_23849224_ChIP-Seq_CD4+_Human0.71498070
151SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.71325802
152TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.70344088
153E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.70205952
154SCL_19346495_ChIP-Seq_HPC-7_Human0.70058229

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.88299371
2MP0004264_abnormal_extraembryonic_tissu4.67244743
3MP0003011_delayed_dark_adaptation4.28826580
4MP0002254_reproductive_system_inflammat4.11526485
5MP0006292_abnormal_olfactory_placode4.08112170
6MP0003890_abnormal_embryonic-extraembry3.62196250
7MP0009379_abnormal_foot_pigmentation3.30833573
8MP0005075_abnormal_melanosome_morpholog3.24510329
9MP0008057_abnormal_DNA_replication3.17840332
10MP0004957_abnormal_blastocyst_morpholog3.15791925
11MP0003122_maternal_imprinting3.07841144
12MP0005394_taste/olfaction_phenotype2.97769622
13MP0005499_abnormal_olfactory_system2.97769622
14MP0005408_hypopigmentation2.93443461
15MP0000678_abnormal_parathyroid_gland2.82134441
16MP0004858_abnormal_nervous_system2.79463586
17MP0000372_irregular_coat_pigmentation2.69459076
18MP0005257_abnormal_intraocular_pressure2.59089010
19MP0002332_abnormal_exercise_endurance2.56633465
20MP0005058_abnormal_lysosome_morphology2.42801649
21MP0002653_abnormal_ependyma_morphology2.29841015
22MP0003705_abnormal_hypodermis_morpholog2.28214348
23MP0010352_gastrointestinal_tract_polyps2.26287817
24MP0003121_genomic_imprinting2.25849345
25MP0006035_abnormal_mitochondrial_morpho2.22631859
26MP0009840_abnormal_foam_cell2.10032524
27MP0009333_abnormal_splenocyte_physiolog2.07175254
28MP0003183_abnormal_peptide_metabolism1.89751332
29MP0005380_embryogenesis_phenotype1.88527094
30MP0001672_abnormal_embryogenesis/_devel1.88527094
31MP0005503_abnormal_tendon_morphology1.82693082
32MP0001542_abnormal_bone_strength1.79675611
33MP0002088_abnormal_embryonic_growth/wei1.75676174
34MP0003984_embryonic_growth_retardation1.74480422
35MP0003123_paternal_imprinting1.67822851
36MP0006054_spinal_hemorrhage1.66386985
37MP0010030_abnormal_orbit_morphology1.61178387
38MP0003279_aneurysm1.58059819
39MP0003077_abnormal_cell_cycle1.57013438
40MP0003938_abnormal_ear_development1.55821616
41MP0002127_abnormal_cardiovascular_syste1.54761366
42MP0000350_abnormal_cell_proliferation1.53753817
43MP0001293_anophthalmia1.53230455
44MP0008961_abnormal_basal_metabolism1.52786764
45MP0000049_abnormal_middle_ear1.51855111
46MP0001853_heart_inflammation1.48072704
47MP0001849_ear_inflammation1.47995464
48MP0002277_abnormal_respiratory_mucosa1.47913088
49MP0003191_abnormal_cellular_cholesterol1.46186946
50MP0003283_abnormal_digestive_organ1.45865345
51MP0005360_urolithiasis1.42252310
52MP0004043_abnormal_pH_regulation1.40963052
53MP0002938_white_spotting1.39461720
54MP0005266_abnormal_metabolism1.37702594
55MP0002932_abnormal_joint_morphology1.37270355
56MP0000762_abnormal_tongue_morphology1.33386871
57MP0002086_abnormal_extraembryonic_tissu1.32677867
58MP0006082_CNS_inflammation1.32045654
59MP0004133_heterotaxia1.31609594
60MP0002085_abnormal_embryonic_tissue1.31515311
61MP0002092_abnormal_eye_morphology1.31405049
62MP0003941_abnormal_skin_development1.28802351
63MP0005171_absent_coat_pigmentation1.26648397
64MP0003119_abnormal_digestive_system1.26177556
65MP0003111_abnormal_nucleus_morphology1.25928117
66MP0000858_altered_metastatic_potential1.25473960
67MP0005275_abnormal_skin_tensile1.25403961
68MP0008789_abnormal_olfactory_epithelium1.24862309
69MP0009785_altered_susceptibility_to1.22616227
70MP0001873_stomach_inflammation1.20244236
71MP0003693_abnormal_embryo_hatching1.18588683
72MP0002084_abnormal_developmental_patter1.17031366
73MP0001348_abnormal_lacrimal_gland1.15945024
74MP0002396_abnormal_hematopoietic_system1.15261466
75MP0001764_abnormal_homeostasis1.15158560
76MP0005197_abnormal_uvea_morphology1.15050584
77MP0003950_abnormal_plasma_membrane1.14889170
78MP0002163_abnormal_gland_morphology1.13607060
79MP0000613_abnormal_salivary_gland1.13339143
80MP0008932_abnormal_embryonic_tissue1.12395969
81MP0004197_abnormal_fetal_growth/weight/1.11899590
82MP0010094_abnormal_chromosome_stability1.11510786
83MP0002060_abnormal_skin_morphology1.11361109
84MP0003436_decreased_susceptibility_to1.11110672
85MP0002233_abnormal_nose_morphology1.10913415
86MP0002148_abnormal_hypersensitivity_rea1.07215380
87MP0002970_abnormal_white_adipose1.05414434
88MP0000490_abnormal_crypts_of1.05094338
89MP0000685_abnormal_immune_system1.04826774
90MP0008260_abnormal_autophagy1.04785655
91MP0005508_abnormal_skeleton_morphology1.04382964
92MP0002114_abnormal_axial_skeleton1.04203028
93MP0001881_abnormal_mammary_gland1.04177522
94MP0001243_abnormal_dermal_layer1.03870465
95MP0002877_abnormal_melanocyte_morpholog1.03500879
96MP0001730_embryonic_growth_arrest1.03493544
97MP0000432_abnormal_head_morphology1.01609749
98MP0000428_abnormal_craniofacial_morphol0.99956480
99MP0000313_abnormal_cell_death0.99891574
100MP0003755_abnormal_palate_morphology0.99796105
101MP0003935_abnormal_craniofacial_develop0.98653097
102MP0008007_abnormal_cellular_replicative0.97753133
103MP0008058_abnormal_DNA_repair0.96779418
104MP0002295_abnormal_pulmonary_circulatio0.96299008
105MP0000343_altered_response_to0.96142078
106MP0001845_abnormal_inflammatory_respons0.94077476
107MP0001697_abnormal_embryo_size0.93592797
108MP0005084_abnormal_gallbladder_morpholo0.93544512
109MP0008469_abnormal_protein_level0.93246932
110MP0002080_prenatal_lethality0.91637900
111MP0005379_endocrine/exocrine_gland_phen0.91506409
112MP0002751_abnormal_autonomic_nervous0.90733266
113MP0000750_abnormal_muscle_regeneration0.88246984
114MP0003136_yellow_coat_color0.87890842
115MP0002132_abnormal_respiratory_system0.87167191
116MP0005023_abnormal_wound_healing0.86611235
117MP0009384_cardiac_valve_regurgitation0.86574278
118MP0005025_abnormal_response_to0.85435854
119MP0005671_abnormal_response_to0.85223270
120MP0005501_abnormal_skin_physiology0.85093350
121MP0010155_abnormal_intestine_physiology0.84243261
122MP0005193_abnormal_anterior_eye0.82777887
123MP0005391_vision/eye_phenotype0.82515402
124MP0005319_abnormal_enzyme/_coenzyme0.82181652
125MP0009053_abnormal_anal_canal0.82059536
126MP0004019_abnormal_vitamin_homeostasis0.81745866
127MP0000358_abnormal_cell_content/0.80067036
128MP0005390_skeleton_phenotype0.80045455
129MP0001270_distended_abdomen0.78058994
130MP0001666_abnormal_nutrient_absorption0.78031197
131MP0002925_abnormal_cardiovascular_devel0.77906295
132MP0003806_abnormal_nucleotide_metabolis0.76790713
133MP0005248_abnormal_Harderian_gland0.76349917
134MP0002116_abnormal_craniofacial_bone0.76265111
135MP0009703_decreased_birth_body0.76192377
136MP0005365_abnormal_bile_salt0.76141798
137MP0008770_decreased_survivor_rate0.75944532
138MP0009643_abnormal_urine_homeostasis0.75094320
139MP0001286_abnormal_eye_development0.74445210
140MP0001533_abnormal_skeleton_physiology0.73991832
141MP0001661_extended_life_span0.72673131
142MP0008995_early_reproductive_senescence0.72329675
143MP0003787_abnormal_imprinting0.72261315
144MP0004782_abnormal_surfactant_physiolog0.71725555
145MP0000749_muscle_degeneration0.71681855
146MP0002098_abnormal_vibrissa_morphology0.71190659
147MP0002933_joint_inflammation0.71129561
148MP0003795_abnormal_bone_structure0.70924397
149MP0005165_increased_susceptibility_to0.70906558
150MP0003566_abnormal_cell_adhesion0.70011887
151MP0005083_abnormal_biliary_tract0.69894548
152MP0002269_muscular_atrophy0.69761457
153MP0004381_abnormal_hair_follicle0.69666992
154MP0001727_abnormal_embryo_implantation0.69419458
155MP0003315_abnormal_perineum_morphology0.69384684
156MP0002139_abnormal_hepatobiliary_system0.68723868
157MP0002095_abnormal_skin_pigmentation0.68119617
158MP0000538_abnormal_urinary_bladder0.67583666
159MP0003763_abnormal_thymus_physiology0.67132712
160MP0005164_abnormal_response_to0.66031863
161MP0004272_abnormal_basement_membrane0.65915023
162MP0003137_abnormal_impulse_conducting0.65907402
163MP0002419_abnormal_innate_immunity0.65252870
164MP0003186_abnormal_redox_activity0.64817603
165MP0003937_abnormal_limbs/digits/tail_de0.64758851
166MP0006036_abnormal_mitochondrial_physio0.63627615
167MP0003786_premature_aging0.62228925
168MP0000163_abnormal_cartilage_morphology0.61699190
169MP0005384_cellular_phenotype0.60239477
170MP0002249_abnormal_larynx_morphology0.58923995
171MP0002111_abnormal_tail_morphology0.58841580

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)7.41902792
2Hypochromic microcytic anemia (HP:0004840)5.72893411
3Hepatoblastoma (HP:0002884)5.72624319
4Multiple enchondromatosis (HP:0005701)5.33408102
5Reticulocytopenia (HP:0001896)4.65528278
6Rib fusion (HP:0000902)4.61535274
7Abnormality of the lower motor neuron (HP:0002366)4.56085776
8Ependymoma (HP:0002888)4.34279850
9Abnormality of cells of the erythroid lineage (HP:0012130)4.18390660
10Premature rupture of membranes (HP:0001788)4.05639527
11Acute necrotizing encephalopathy (HP:0006965)4.00088246
12Mitochondrial inheritance (HP:0001427)3.96635658
13Hyperinsulinemic hypoglycemia (HP:0000825)3.91419152
14Abnormal number of erythroid precursors (HP:0012131)3.89648240
15Nephroblastoma (Wilms tumor) (HP:0002667)3.86072974
16Abnormal mitochondria in muscle tissue (HP:0008316)3.84858249
17Aplasia/Hypoplasia of the fovea (HP:0008060)3.82210243
18Hypoplasia of the fovea (HP:0007750)3.82210243
19Neoplasm of striated muscle (HP:0009728)3.73917167
20Hepatocellular necrosis (HP:0001404)3.70483051
21Rhabdomyosarcoma (HP:0002859)3.68782102
22Vertebral compression fractures (HP:0002953)3.67534711
23Chromosomal breakage induced by crosslinking agents (HP:0003221)3.63662601
24Increased hepatocellular lipid droplets (HP:0006565)3.60548769
25Macrocytic anemia (HP:0001972)3.60369607
26Embryonal renal neoplasm (HP:0011794)3.58765164
27Acute encephalopathy (HP:0006846)3.56013388
28Lipid accumulation in hepatocytes (HP:0006561)3.50418868
29Increased CSF lactate (HP:0002490)3.48409487
30Fused cervical vertebrae (HP:0002949)3.43074159
31Abnormal protein glycosylation (HP:0012346)3.35705139
32Abnormal glycosylation (HP:0012345)3.35705139
33Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.35705139
34Abnormal protein N-linked glycosylation (HP:0012347)3.35705139
35Hepatic necrosis (HP:0002605)3.31680774
36Testicular atrophy (HP:0000029)3.28476300
37Reduced antithrombin III activity (HP:0001976)3.22285015
38Renal Fanconi syndrome (HP:0001994)3.17820587
39Bifid tongue (HP:0010297)3.17218113
40Rectovaginal fistula (HP:0000143)3.15765890
41Rectal fistula (HP:0100590)3.15765890
42Trismus (HP:0000211)3.12616238
43Chromsome breakage (HP:0040012)3.10212417
44Partial duplication of thumb phalanx (HP:0009944)3.07915707
45Progressive macrocephaly (HP:0004481)3.02092480
46Abnormal cartilage morphology (HP:0002763)2.97727977
47Ragged-red muscle fibers (HP:0003200)2.96374744
48Vacuolated lymphocytes (HP:0001922)2.96095748
49Abnormal lung lobation (HP:0002101)2.93114787
50Aplasia/hypoplasia of the humerus (HP:0006507)2.92890589
51Abnormality of the astrocytes (HP:0100707)2.91777554
52Astrocytoma (HP:0009592)2.91777554
53Abnormality of the salivary glands (HP:0010286)2.90655576
54Abnormality of the fovea (HP:0000493)2.88506296
55Short humerus (HP:0005792)2.84161921
56Intestinal fistula (HP:0100819)2.77436039
57Increased intramyocellular lipid droplets (HP:0012240)2.77408093
58Amyotrophic lateral sclerosis (HP:0007354)2.76215277
59Aplastic anemia (HP:0001915)2.75612691
60Vaginal fistula (HP:0004320)2.75235195
61Abnormality of dentin (HP:0010299)2.72449382
62Partial duplication of the phalanx of hand (HP:0009999)2.69815967
63Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.66938209
64Decreased activity of mitochondrial respiratory chain (HP:0008972)2.66938209
65Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.63428199
66Cerebral edema (HP:0002181)2.61066497
67Anomalous pulmonary venous return (HP:0010772)2.58910409
68Rough bone trabeculation (HP:0100670)2.58448711
69Type I transferrin isoform profile (HP:0003642)2.55828219
70Cervical subluxation (HP:0003308)2.54149687
71Increased muscle lipid content (HP:0009058)2.52244692
72Preauricular skin tag (HP:0000384)2.50980438
73Respiratory difficulties (HP:0002880)2.50203215
74Progressive muscle weakness (HP:0003323)2.50058529
75Aplasia/Hypoplasia of the macula (HP:0008059)2.47128431
76Abnormality of the intrinsic pathway (HP:0010989)2.46423608
77Respiratory failure (HP:0002878)2.45632417
78Protrusio acetabuli (HP:0003179)2.42280431
79Shawl scrotum (HP:0000049)2.42276638
80Horizontal nystagmus (HP:0000666)2.41243204
81Meckel diverticulum (HP:0002245)2.40818966
82Hypochromic anemia (HP:0001931)2.38206538
83Short 5th finger (HP:0009237)2.36312000
84Impulsivity (HP:0100710)2.36009015
85Tongue fasciculations (HP:0001308)2.34940885
86Increased serum lactate (HP:0002151)2.33524476
87Aplasia/Hypoplasia of the uvula (HP:0010293)2.32560098
88Villous atrophy (HP:0011473)2.31673104
89Abnormality of small intestinal villus morphology (HP:0011472)2.31673104
90Lactic acidosis (HP:0003128)2.31072202
91Abnormality of glycolipid metabolism (HP:0010969)2.30136210
92Abnormality of liposaccharide metabolism (HP:0010968)2.30136210
93Abnormality of glycosphingolipid metabolism (HP:0004343)2.30136210
94Generalized hypotonia (HP:0001290)2.27934930
95Glossoptosis (HP:0000162)2.27598188
96Exertional dyspnea (HP:0002875)2.25783946
97Hand muscle atrophy (HP:0009130)2.25166287
98Abnormality of the ileum (HP:0001549)2.24704731
99Tetraplegia (HP:0002445)2.23604860
100Aplasia/Hypoplasia affecting the retina (HP:0008061)2.22937144
101Microretrognathia (HP:0000308)2.22226924
102Glioma (HP:0009733)2.20412847
103Preauricular pit (HP:0004467)2.19100117
104Periauricular skin pits (HP:0100277)2.19100117
105Abnormality of the pulmonary veins (HP:0011718)2.18354771
106Nasolacrimal duct obstruction (HP:0000579)2.16844712
107Abnormality of the musculature of the hand (HP:0001421)2.15599039
108Skin tags (HP:0010609)2.15509383
109Aplasia/Hypoplasia of the sternum (HP:0006714)2.15285384
110Missing ribs (HP:0000921)2.14987448
111Atrophy/Degeneration involving motor neurons (HP:0007373)2.14502131
112Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.13414901
113Microvesicular hepatic steatosis (HP:0001414)2.13336511
114Thrombocytosis (HP:0001894)2.12298089
115Pallor (HP:0000980)2.12239278
116Nonimmune hydrops fetalis (HP:0001790)2.10639937
117Prolonged neonatal jaundice (HP:0006579)2.10424190
118Abnormality of chromosome segregation (HP:0002916)2.10250539
119Muscle fibrillation (HP:0010546)2.09757031
120Hyperventilation (HP:0002883)2.09362894
121Exercise intolerance (HP:0003546)2.08380411
122Large earlobe (HP:0009748)2.08330219
123Supernumerary spleens (HP:0009799)2.07812695
124Aplasia/Hypoplasia of the sacrum (HP:0008517)2.07736923
125Abnormality of the phalanges of the hallux (HP:0010057)2.06838112
126Neoplasm of the heart (HP:0100544)2.05349291
127Malignant neoplasm of the central nervous system (HP:0100836)2.04747426
128Abnormality of the pubic bones (HP:0003172)2.04491547
129Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.04041199
130Degeneration of anterior horn cells (HP:0002398)2.00985384
131Abnormality of the anterior horn cell (HP:0006802)2.00985384
132Facial cleft (HP:0002006)1.99941636
133Increased connective tissue (HP:0009025)1.98173545
134Cheilitis (HP:0100825)1.97253095
135Spinal muscular atrophy (HP:0007269)1.96901273
136Abnormal trabecular bone morphology (HP:0100671)1.95872157
137Generalized aminoaciduria (HP:0002909)1.94554563
138Duodenal stenosis (HP:0100867)1.93647136
139Small intestinal stenosis (HP:0012848)1.93647136
140Combined immunodeficiency (HP:0005387)1.93197393
141Abnormality of the distal phalanx of the thumb (HP:0009617)1.92105608
142Hypokinesia (HP:0002375)1.91976008
143Sensory axonal neuropathy (HP:0003390)1.91542456
144Angiofibromas (HP:0010615)1.90300886
145Adenoma sebaceum (HP:0009720)1.90300886
1463-Methylglutaconic aciduria (HP:0003535)1.90241832
147Renal duplication (HP:0000075)1.89631725
148Embryonal neoplasm (HP:0002898)1.88189683
149Sparse eyelashes (HP:0000653)1.88178027
150Vertebral fusion (HP:0002948)1.87692343
151Delayed cranial suture closure (HP:0000270)1.87487216
152Esophageal neoplasm (HP:0100751)1.86373012
153Neoplasm of head and neck (HP:0012288)1.86373012
154Entropion (HP:0000621)1.84133795
155Poor head control (HP:0002421)1.83872938
156Redundant skin (HP:0001582)1.82279740
157Elevated erythrocyte sedimentation rate (HP:0003565)1.81087650
158Lethargy (HP:0001254)1.79964173
159Dysostosis multiplex (HP:0000943)1.78608389
160Blue sclerae (HP:0000592)1.77151573
161Opisthotonus (HP:0002179)1.76819307
162Pancytopenia (HP:0001876)1.76485678
163Abnormality of renal resorption (HP:0011038)1.73932401
164Glycosuria (HP:0003076)1.72157105
165Abnormality of urine glucose concentration (HP:0011016)1.72157105
166Hyperphosphaturia (HP:0003109)1.71745325
167CNS demyelination (HP:0007305)1.71075572
168Beaking of vertebral bodies (HP:0004568)1.69632861
169Spastic paraparesis (HP:0002313)1.68806183
170Joint stiffness (HP:0001387)1.65943344
171Patchy hypopigmentation of hair (HP:0011365)1.64869777
172Flat capital femoral epiphysis (HP:0003370)1.63976122
173Abnormality of the umbilical cord (HP:0010881)1.63498351
174Loss of speech (HP:0002371)1.62737599
175Abnormality of placental membranes (HP:0011409)1.62679230
176Amniotic constriction ring (HP:0009775)1.62679230
177Oral leukoplakia (HP:0002745)1.61752095
178Neutropenia (HP:0001875)1.61107210
179Optic disc pallor (HP:0000543)1.60859715
180Abnormality of the distal phalanges of the toes (HP:0010182)1.60483334
181Increased serum pyruvate (HP:0003542)1.59660551
182Abnormalities of placenta or umbilical cord (HP:0001194)1.59114105
183Dicarboxylic aciduria (HP:0003215)1.58660857
184Abnormality of dicarboxylic acid metabolism (HP:0010995)1.58660857
185J-shaped sella turcica (HP:0002680)1.55985808
186Abnormality of T cell physiology (HP:0011840)1.55687911
187Congenital ichthyosiform erythroderma (HP:0007431)1.55678938

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.98136915
2GRK55.28112211
3ERN15.20820517
4VRK24.69707277
5GRK64.29265564
6ADRBK23.28653396
7GRK13.27084492
8TESK13.07341254
9STK162.90639875
10CSF1R2.78876198
11TTK2.77246096
12TGFBR22.64043585
13GRK72.38955747
14MAPK72.35386519
15LRRK22.34379732
16TYRO32.34302595
17LIMK12.32380375
18STK102.19563099
19MATK2.15369926
20MAP3K122.13305108
21MOS1.96753696
22PBK1.89993656
23WNK11.87582469
24PIM21.74854513
25CDK71.74662727
26EPHA21.74366384
27PRKG21.68769563
28KDR1.62159613
29IRAK31.47819635
30PAK41.46121112
31AKT31.46014364
32NME11.45703410
33VRK11.44290419
34NTRK11.43650088
35EIF2AK11.41022679
36HIPK21.40688910
37CAMK41.36466289
38CHEK21.30273206
39MYLK1.25268107
40PLK11.21910030
41ILK1.20003405
42BRSK11.18191492
43MARK21.13331537
44MAP3K101.11498494
45ADRBK11.10591776
46ZAK1.10441998
47ZAP701.06899810
48TBK11.06615496
49ABL21.04365870
50EPHB21.00335174
51MST1R0.98848844
52PDK20.97353604
53TLK10.94920940
54MAP4K10.94694171
55TYK20.94316093
56SCYL20.92803901
57CSNK1G30.91087807
58ARAF0.87924496
59SIK30.86594463
60SMG10.84270764
61ERBB40.82324951
62FGFR30.81833064
63BUB10.79593579
64CDC70.79175413
65CHEK10.78062130
66DAPK30.76310259
67LMTK20.75220576
68EIF2AK20.75030906
69MAP2K60.74736823
70WEE10.73311460
71ALK0.71256992
72MAP2K40.70877937
73AKT20.70340740
74CSK0.67367924
75RPS6KB20.65441279
76PRKCI0.64966135
77DAPK10.64313457
78CSNK1A1L0.63622853
79TXK0.63586163
80MAP3K110.61301709
81NEK20.60619378
82TRIM280.59820687
83AURKA0.56736148
84PKN20.56054179
85MAP2K20.55204075
86CSNK2A20.55011932
87CSNK2A10.54685192
88TESK20.53972435
89MTOR0.53144669
90TGFBR10.51084237
91CSNK1G10.51052971
92MAP3K70.48652876
93PTK20.47903557
94LATS20.47819700
95CDK20.47366579
96EPHB10.47205941
97MAPK120.46852220
98AURKB0.46099008
99BRAF0.45805552
100PTK60.45798859
101IRAK40.44670772
102IKBKE0.44578037
103MAP4K20.43321825
104TRIB30.42513707
105JAK30.40905393
106MAPKAPK30.40883220
107RPS6KA40.40866537
108DYRK30.40646646
109FGFR40.40444051
110MUSK0.40384067
111IGF1R0.38534718
112PAK10.38369666
113CDK40.38296472
114MAP2K70.37900922
115NUAK10.37644269
116FLT30.36559213
117CDK190.35751667
118ATM0.35413305
119SRPK10.34752548
120PRKCD0.33555578
121PASK0.32738634
122DYRK20.31302974
123NEK10.30902942
124ITK0.30417433
125IKBKB0.30341669
126BRSK20.29140319
127PDGFRA0.28737309
128CSNK1E0.27417289
129CDK80.27074852
130DDR20.25653482
131ERBB20.25148285
132CDK10.24641972
133MST40.22082627
134NME20.20730506
135MAPK10.20291351
136TAOK20.18843190
137MAPK100.18680439
138INSR0.18417268
139EIF2AK30.17691464
140PRKD20.17259679
141MAPK140.17102400
142RIPK10.15363639
143GSK3B0.15170831
144GSK3A0.14993602
145DYRK1B0.14677318
146MET0.13211178
147CHUK0.13155642
148PRKACG0.12934925
149DYRK1A0.12906668
150MAP3K30.12200169
151BCKDK0.12165120
152ATR0.11982388
153CDK150.11638378
154MAPKAPK20.11600370
155PAK30.11550825
156CDK11A0.11415166
157SIK10.10510242
158MAPK40.10456759
159MAP3K80.10218063

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006035.88614309
2Vitamin B6 metabolism_Homo sapiens_hsa007505.80346167
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.24314388
4Fructose and mannose metabolism_Homo sapiens_hsa000513.95284287
5Oxidative phosphorylation_Homo sapiens_hsa001903.48671450
6Galactose metabolism_Homo sapiens_hsa000523.04697013
7Parkinsons disease_Homo sapiens_hsa050122.87246782
8Arachidonic acid metabolism_Homo sapiens_hsa005902.78991471
9Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.31799779
10Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.26226448
11Linoleic acid metabolism_Homo sapiens_hsa005912.12483637
12Sulfur metabolism_Homo sapiens_hsa009202.06929210
13RNA transport_Homo sapiens_hsa030132.05277095
14DNA replication_Homo sapiens_hsa030302.04816302
15Ribosome_Homo sapiens_hsa030102.03916477
16N-Glycan biosynthesis_Homo sapiens_hsa005101.99326287
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.98588282
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.97509667
19Huntingtons disease_Homo sapiens_hsa050161.90860934
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.85251264
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.79970541
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.76690302
23Alzheimers disease_Homo sapiens_hsa050101.76245783
24Other glycan degradation_Homo sapiens_hsa005111.73652421
25Mismatch repair_Homo sapiens_hsa034301.67408590
26One carbon pool by folate_Homo sapiens_hsa006701.67190437
27Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.65663791
28Thyroid cancer_Homo sapiens_hsa052161.60061926
29Fatty acid elongation_Homo sapiens_hsa000621.57831145
30Fanconi anemia pathway_Homo sapiens_hsa034601.49417758
31Vibrio cholerae infection_Homo sapiens_hsa051101.46919166
32Homologous recombination_Homo sapiens_hsa034401.41129953
33Cell cycle_Homo sapiens_hsa041101.37703470
34Glycosaminoglycan degradation_Homo sapiens_hsa005311.37001596
35mRNA surveillance pathway_Homo sapiens_hsa030151.36351001
36Folate biosynthesis_Homo sapiens_hsa007901.34341936
37Cyanoamino acid metabolism_Homo sapiens_hsa004601.32264582
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.30343251
39Spliceosome_Homo sapiens_hsa030401.27174719
40RNA degradation_Homo sapiens_hsa030181.26607385
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.26273687
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.22129358
43RNA polymerase_Homo sapiens_hsa030201.18936168
44Maturity onset diabetes of the young_Homo sapiens_hsa049501.18849943
45Lysosome_Homo sapiens_hsa041421.14594787
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.13208118
47mTOR signaling pathway_Homo sapiens_hsa041501.12635088
48Base excision repair_Homo sapiens_hsa034101.12383625
49Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.04529627
50Pentose phosphate pathway_Homo sapiens_hsa000300.98899540
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.96473695
52Chemical carcinogenesis_Homo sapiens_hsa052040.89581570
53p53 signaling pathway_Homo sapiens_hsa041150.89264941
54Antigen processing and presentation_Homo sapiens_hsa046120.87726378
55Primary immunodeficiency_Homo sapiens_hsa053400.85337249
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83915805
57RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.83573548
58Selenocompound metabolism_Homo sapiens_hsa004500.82770693
59Pyrimidine metabolism_Homo sapiens_hsa002400.80069298
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79965305
61Purine metabolism_Homo sapiens_hsa002300.78522664
62Collecting duct acid secretion_Homo sapiens_hsa049660.78312699
63Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.75646667
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.74124275
65Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73807980
66* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73794412
67Sulfur relay system_Homo sapiens_hsa041220.73385679
68Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.72834248
69Ether lipid metabolism_Homo sapiens_hsa005650.70555059
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.70274628
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70048983
72Basal transcription factors_Homo sapiens_hsa030220.69061711
73Tryptophan metabolism_Homo sapiens_hsa003800.67506808
74Basal cell carcinoma_Homo sapiens_hsa052170.66304731
75Central carbon metabolism in cancer_Homo sapiens_hsa052300.66280337
76Protein export_Homo sapiens_hsa030600.66259390
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.63995940
78Sphingolipid metabolism_Homo sapiens_hsa006000.63764627
79Ovarian steroidogenesis_Homo sapiens_hsa049130.63245717
80Nucleotide excision repair_Homo sapiens_hsa034200.62463531
81Carbon metabolism_Homo sapiens_hsa012000.61966048
82Peroxisome_Homo sapiens_hsa041460.59474015
83Biosynthesis of amino acids_Homo sapiens_hsa012300.58098437
84Shigellosis_Homo sapiens_hsa051310.57123063
85Fat digestion and absorption_Homo sapiens_hsa049750.56465797
86Hedgehog signaling pathway_Homo sapiens_hsa043400.56458747
87Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56294792
88Non-homologous end-joining_Homo sapiens_hsa034500.56212381
89Pathways in cancer_Homo sapiens_hsa052000.55882044
90Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.54898035
91Acute myeloid leukemia_Homo sapiens_hsa052210.54639966
92Steroid biosynthesis_Homo sapiens_hsa001000.54009648
93Inositol phosphate metabolism_Homo sapiens_hsa005620.53292622
94Bladder cancer_Homo sapiens_hsa052190.52604777
95Epstein-Barr virus infection_Homo sapiens_hsa051690.51890086
96Rheumatoid arthritis_Homo sapiens_hsa053230.51176255
97MicroRNAs in cancer_Homo sapiens_hsa052060.49647789
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.48500943
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48086471
100Proteasome_Homo sapiens_hsa030500.47401100
101Herpes simplex infection_Homo sapiens_hsa051680.43715898
102Regulation of autophagy_Homo sapiens_hsa041400.42517095
103Protein digestion and absorption_Homo sapiens_hsa049740.42296380
104Hippo signaling pathway_Homo sapiens_hsa043900.41728255
105Pyruvate metabolism_Homo sapiens_hsa006200.41725275
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40662034
107Cardiac muscle contraction_Homo sapiens_hsa042600.39656589
108Phagosome_Homo sapiens_hsa041450.39428729
109Metabolic pathways_Homo sapiens_hsa011000.38481756
110Vitamin digestion and absorption_Homo sapiens_hsa049770.37598980
111Allograft rejection_Homo sapiens_hsa053300.35345470
112Graft-versus-host disease_Homo sapiens_hsa053320.34640896
113Autoimmune thyroid disease_Homo sapiens_hsa053200.34265719
114Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33467768
115Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.32648583
116Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32100503
117Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.32077599
118Renin-angiotensin system_Homo sapiens_hsa046140.31891959
119Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.31404394
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.31400486
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30266364
122Apoptosis_Homo sapiens_hsa042100.30003228
123Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29345309
124Tyrosine metabolism_Homo sapiens_hsa003500.28565766
125Notch signaling pathway_Homo sapiens_hsa043300.27994139
126Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.27785888
127Legionellosis_Homo sapiens_hsa051340.27779912
1282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.27607522
129Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.26022329
130Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.25539549
131Choline metabolism in cancer_Homo sapiens_hsa052310.24622907
132Starch and sucrose metabolism_Homo sapiens_hsa005000.24296301
133AMPK signaling pathway_Homo sapiens_hsa041520.24187591
134Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.23725338
135Cysteine and methionine metabolism_Homo sapiens_hsa002700.23383182
136Rap1 signaling pathway_Homo sapiens_hsa040150.23365506
137African trypanosomiasis_Homo sapiens_hsa051430.22890633
138Primary bile acid biosynthesis_Homo sapiens_hsa001200.22609269
139PI3K-Akt signaling pathway_Homo sapiens_hsa041510.22179199
140Drug metabolism - other enzymes_Homo sapiens_hsa009830.22139793
141Propanoate metabolism_Homo sapiens_hsa006400.20238665
142Non-small cell lung cancer_Homo sapiens_hsa052230.19029532
143Glutathione metabolism_Homo sapiens_hsa004800.18688832
144HTLV-I infection_Homo sapiens_hsa051660.18382749
145Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.18194361
146Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.17821722
147Viral carcinogenesis_Homo sapiens_hsa052030.17689211
148Wnt signaling pathway_Homo sapiens_hsa043100.17552440
149Proteoglycans in cancer_Homo sapiens_hsa052050.13567913
150Complement and coagulation cascades_Homo sapiens_hsa046100.12989461
151Leukocyte transendothelial migration_Homo sapiens_hsa046700.12894371

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »