SSPO

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous antigen (GO:0019883)8.80430371
2oxygen transport (GO:0015671)8.51465210
3regulation of dendritic cell antigen processing and presentation (GO:0002604)8.11533597
4NIK/NF-kappaB signaling (GO:0038061)8.01524271
5neurotransmitter catabolic process (GO:0042135)7.44332339
6imidazole-containing compound metabolic process (GO:0052803)6.94186652
7substrate-independent telencephalic tangential migration (GO:0021826)6.73722648
8substrate-independent telencephalic tangential interneuron migration (GO:0021843)6.73722648
9positive regulation of granulocyte chemotaxis (GO:0071624)6.08340885
10positive regulation of antigen processing and presentation (GO:0002579)5.99687445
11regulation of antigen processing and presentation (GO:0002577)5.11005488
12regulation of T-helper 1 cell differentiation (GO:0045625)5.04309651
13virion attachment to host cell (GO:0019062)4.81377878
14adhesion of symbiont to host cell (GO:0044650)4.81377878
15gas transport (GO:0015669)4.80807283
16positive regulation of protein kinase C signaling (GO:0090037)4.68450141
17membrane tubulation (GO:0097320)4.67248747
18asymmetric protein localization (GO:0008105)4.65799851
19cellular response to ATP (GO:0071318)4.62652679
20regulation of bile acid biosynthetic process (GO:0070857)4.46504701
21bundle of His cell to Purkinje myocyte communication (GO:0086069)4.46151113
22negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 4.40316529
23proline transport (GO:0015824)4.38757172
24antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.36012796
25antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.36012796
26regulation of MHC class II biosynthetic process (GO:0045346)4.29995770
27positive regulation of natural killer cell differentiation (GO:0032825)4.28971392
28positive regulation of T-helper cell differentiation (GO:0045624)4.24402771
29positive regulation of T-helper 1 type immune response (GO:0002827)4.24116907
30positive regulation of monocyte chemotaxis (GO:0090026)4.07977839
31positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.98594849
32myeloid dendritic cell differentiation (GO:0043011)3.95490729
33negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)3.95191575
34positive regulation of cholesterol efflux (GO:0010875)3.94738305
35regulation of cellular extravasation (GO:0002691)3.93910664
36positive regulation of Cdc42 GTPase activity (GO:0043089)3.87563436
37regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 3.87561601
38negative thymic T cell selection (GO:0045060)3.86841176
39regulation of natural killer cell differentiation (GO:0032823)3.85552824
40diaphragm development (GO:0060539)3.85091235
41positive regulation of neutrophil chemotaxis (GO:0090023)3.79987552
42positive regulation of neutrophil migration (GO:1902624)3.79987552
43regulation of Cdc42 GTPase activity (GO:0043088)3.77616633
44positive regulation of heat generation (GO:0031652)3.76438402
45adhesion of symbiont to host (GO:0044406)3.75254124
46synaptic vesicle docking involved in exocytosis (GO:0016081)3.70992467
47regulation of granulocyte chemotaxis (GO:0071622)3.69240658
48myelin maintenance (GO:0043217)3.66090412
49positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.63755583
50positive regulation of macrophage cytokine production (GO:0060907)3.61038490
51regulation of fever generation (GO:0031620)3.59841249
52dendritic cell differentiation (GO:0097028)3.59645356
53positive regulation of cholesterol transport (GO:0032376)3.54179168
54positive regulation of sterol transport (GO:0032373)3.54179168
55protein localization to endosome (GO:0036010)3.50534658
56negative T cell selection (GO:0043383)3.49987536
57skeletal muscle organ development (GO:0060538)3.49372494
58regulation of Golgi to plasma membrane protein transport (GO:0042996)3.48989106
59positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.48868453
60regulation of ARF GTPase activity (GO:0032312)3.43310783
61regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.41017530
62urinary tract smooth muscle contraction (GO:0014848)3.40200108
63dendritic spine morphogenesis (GO:0060997)3.38584791
64positive regulation of CREB transcription factor activity (GO:0032793)3.34535680
65regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.32369926
66positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.32304468
67negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)3.29202756
68positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)3.26282867
69regulation of heat generation (GO:0031650)3.20030936
70Leydig cell differentiation (GO:0033327)3.17471680
71axonal fasciculation (GO:0007413)3.15366056
72myeloid dendritic cell activation (GO:0001773)3.12357256
73regulation of T-helper cell differentiation (GO:0045622)3.11645377
74regulation of T-helper 1 type immune response (GO:0002825)3.08598332
75fatty acid homeostasis (GO:0055089)3.07009025
76negative regulation of interleukin-10 production (GO:0032693)3.06479956
77fucose catabolic process (GO:0019317)3.06294843
78L-fucose metabolic process (GO:0042354)3.06294843
79L-fucose catabolic process (GO:0042355)3.06294843
80positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.05202472
81positive thymic T cell selection (GO:0045059)3.04168166
82peptide catabolic process (GO:0043171)3.01956294
83positive regulation of filopodium assembly (GO:0051491)3.00636314
84regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.98739567
85prostanoid biosynthetic process (GO:0046457)2.98244748
86prostaglandin biosynthetic process (GO:0001516)2.98244748
87neuronal ion channel clustering (GO:0045161)2.96476340
88semaphorin-plexin signaling pathway (GO:0071526)2.95252532
89locomotory exploration behavior (GO:0035641)2.95179757
90regulation of synapse maturation (GO:0090128)2.93841850
91positive regulation of insulin receptor signaling pathway (GO:0046628)2.93487700
92positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.90585001
93regulation of memory T cell differentiation (GO:0043380)2.90492229
94regulation of activation of Janus kinase activity (GO:0010533)2.89885753
95antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.88150243
96positive regulation of histone deacetylation (GO:0031065)2.86696337
97JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.85159887
98regulation of cholesterol efflux (GO:0010874)2.83427967
99negative regulation of cell size (GO:0045792)2.83226328
100regulation of protein kinase C signaling (GO:0090036)2.82828507
101pyrimidine dimer repair (GO:0006290)2.82359346
102regulation of neutrophil chemotaxis (GO:0090022)2.82250586
103regulation of neutrophil migration (GO:1902622)2.82250586
104nephron epithelium morphogenesis (GO:0072088)2.81954422
105nephron tubule morphogenesis (GO:0072078)2.81954422
106ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.80914238
107white fat cell differentiation (GO:0050872)2.78813024
108positive regulation of type 2 immune response (GO:0002830)2.78665468
109regulation of leukocyte mediated cytotoxicity (GO:0001910)2.78644729
110epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.77676102
111creatine metabolic process (GO:0006600)2.77661100
112detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.77494675
113single strand break repair (GO:0000012)2.76853736
114dentate gyrus development (GO:0021542)2.75174744
115ovulation from ovarian follicle (GO:0001542)2.74440264
116cerebellar granule cell differentiation (GO:0021707)2.74348797
117hemidesmosome assembly (GO:0031581)2.73869245
118negative regulation of B cell apoptotic process (GO:0002903)2.73046450
119regulation of short-term neuronal synaptic plasticity (GO:0048172)2.72938196
120positive regulation of natural killer cell activation (GO:0032816)2.72116930
121regulation of monocyte chemotaxis (GO:0090025)2.71590093
122fibroblast migration (GO:0010761)2.70372155
123regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)2.70080162
124synaptic transmission, cholinergic (GO:0007271)2.69269478
125regulation of hydrogen peroxide metabolic process (GO:0010310)2.68951872
126negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.65083410
127positive regulation of synapse maturation (GO:0090129)2.61488885
128positive regulation of membrane potential (GO:0045838)2.60972702
129neurotransmitter-gated ion channel clustering (GO:0072578)2.60621150
130peptidyl-tyrosine autophosphorylation (GO:0038083)2.59851101
131mannose metabolic process (GO:0006013)2.59621176
132synaptic vesicle exocytosis (GO:0016079)2.55522901
133membrane depolarization during action potential (GO:0086010)2.54860591
134vocalization behavior (GO:0071625)2.52595342
135postsynaptic membrane organization (GO:0001941)2.51752637
136epithelial cell fate commitment (GO:0072148)2.51461915
137glutamate secretion (GO:0014047)2.51033148
138sulfate transmembrane transport (GO:1902358)2.49145936
139glycerophospholipid catabolic process (GO:0046475)2.48545049
140membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.47252774
141regulation of calcium ion-dependent exocytosis (GO:0017158)2.45087398
142regulation of respiratory system process (GO:0044065)2.42947707
143regulation of synapse structural plasticity (GO:0051823)2.42437455
144protein localization to synapse (GO:0035418)2.41831989
145cell-cell junction maintenance (GO:0045217)2.41031929
146neurotransmitter secretion (GO:0007269)2.40976430
147establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.38606290
148mitochondrion transport along microtubule (GO:0047497)2.38606290
149dendritic spine organization (GO:0097061)2.38596007
150synaptic vesicle maturation (GO:0016188)2.38265125
151neuron maturation (GO:0042551)2.38207612
152auditory receptor cell differentiation (GO:0042491)2.36881369
153axon ensheathment in central nervous system (GO:0032291)2.35755267
154central nervous system myelination (GO:0022010)2.35755267
155endothelial cell chemotaxis (GO:0035767)2.35709231
156presynaptic membrane organization (GO:0097090)2.33018099
157presynaptic membrane assembly (GO:0097105)2.32526861
158establishment of mitochondrion localization (GO:0051654)2.30738188
159regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.28464436
160negative regulation of axon extension involved in axon guidance (GO:0048843)2.28029770
161negative regulation of cytosolic calcium ion concentration (GO:0051481)2.26839044
162chemosensory behavior (GO:0007635)2.26821773
163regulation of neurotransmitter uptake (GO:0051580)2.26552816
164synapse assembly (GO:0007416)2.25658128
165regulation of histone deacetylation (GO:0031063)2.24783429
166synaptic vesicle endocytosis (GO:0048488)2.23671909
167neuron cell-cell adhesion (GO:0007158)2.23438947
168growth hormone secretion (GO:0030252)2.22793593
169regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.22361959
170cell proliferation in forebrain (GO:0021846)2.21099769
171zinc ion homeostasis (GO:0055069)2.21052414
172regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.21041154
173negative regulation of cAMP-mediated signaling (GO:0043951)2.20257953
174detection of light stimulus involved in sensory perception (GO:0050962)2.19829846
175detection of light stimulus involved in visual perception (GO:0050908)2.19829846
176sex differentiation (GO:0007548)2.18963669
177neuromuscular process controlling posture (GO:0050884)2.18962918
178positive regulation of dendrite development (GO:1900006)2.18049876
179regulation of axon extension involved in axon guidance (GO:0048841)2.17911395
180regulation of synaptic vesicle transport (GO:1902803)2.17721803
181auditory behavior (GO:0031223)2.17715230
182histone H3-K4 trimethylation (GO:0080182)2.17599503
183insulin-like growth factor receptor signaling pathway (GO:0048009)2.17584353
184positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.16714652
185lung epithelium development (GO:0060428)2.16691198
186dermatan sulfate metabolic process (GO:0030205)2.16437852
187neuromuscular synaptic transmission (GO:0007274)2.14752753
188regulation of clathrin-mediated endocytosis (GO:2000369)2.14659433
189peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.13457562
190behavioral response to nicotine (GO:0035095)2.13074490
191positive regulation of neurotransmitter transport (GO:0051590)2.12631830
192positive regulation of sodium ion transmembrane transport (GO:1902307)2.11999000
193epithelial cilium movement (GO:0003351)2.09683438
194renal tubule morphogenesis (GO:0061333)2.09122019
195adaptation of signaling pathway (GO:0023058)2.07744541
196axoneme assembly (GO:0035082)2.07717023
197cell migration in hindbrain (GO:0021535)2.07672801
198negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.07659592
199phosphatidylinositol 3-kinase signaling (GO:0014065)2.07375927

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.61291042
2EZH2_22144423_ChIP-Seq_EOC_Human3.94539270
3CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.60226546
4RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.33535565
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.18341118
6FOXO3_23340844_ChIP-Seq_DLD1_Human1.94167126
7ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.94046381
8ESR1_20079471_ChIP-ChIP_T-47D_Human1.93955097
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.87062405
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.85972445
11VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.85225595
12TRIM28_21343339_ChIP-Seq_HEK293_Human1.84471299
13* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.84196855
14IRF8_22096565_ChIP-ChIP_GC-B_Human1.83720253
15SMAD_19615063_ChIP-ChIP_OVARY_Human1.81080661
16REST_21632747_ChIP-Seq_MESCs_Mouse1.78816712
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.78812185
18SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.76263572
19* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.76196279
20CTCF_27219007_Chip-Seq_Bcells_Human1.75795576
21ESR2_21235772_ChIP-Seq_MCF-7_Human1.74125436
22ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.69927907
23ERG_21242973_ChIP-ChIP_JURKAT_Human1.69800318
24ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.69048775
25RNF2_18974828_ChIP-Seq_MESCs_Mouse1.66487444
26EZH2_18974828_ChIP-Seq_MESCs_Mouse1.66487444
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.65486249
28SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.64879505
29* LXR_22292898_ChIP-Seq_THP-1_Human1.64310331
30TCF4_18268006_ChIP-ChIP_LS174T_Human1.60766108
31MTF2_20144788_ChIP-Seq_MESCs_Mouse1.58822129
32JARID2_20064375_ChIP-Seq_MESCs_Mouse1.58680647
33FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.56974954
34* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.56836388
35REST_18959480_ChIP-ChIP_MESCs_Mouse1.55012137
36* DROSHA_22980978_ChIP-Seq_HELA_Human1.53041883
37P68_20966046_ChIP-Seq_HELA_Human1.52944498
38ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.50476581
39SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.46671626
40EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.43986809
41TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.43851717
42SMC4_20622854_ChIP-Seq_HELA_Human1.40333865
43AR_21572438_ChIP-Seq_LNCaP_Human1.40079384
44GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.38067005
45NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.37210648
46STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.36999706
47RNF2_27304074_Chip-Seq_ESCs_Mouse1.35396867
48SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.33968400
49CLOCK_20551151_ChIP-Seq_293T_Human1.32993446
50EZH2_27304074_Chip-Seq_ESCs_Mouse1.32720625
51IRF8_27001747_Chip-Seq_BMDM_Mouse1.31425875
52EGR1_19374776_ChIP-ChIP_THP-1_Human1.30637631
53CREB1_26743006_Chip-Seq_LNCaP_Human1.30175829
54AHR_22903824_ChIP-Seq_MCF-7_Human1.29995216
55IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.28252409
56KDM2B_26808549_Chip-Seq_DND41_Human1.28060471
57IRF8_21731497_ChIP-ChIP_J774_Mouse1.27460623
58VDR_22108803_ChIP-Seq_LS180_Human1.26972255
59EZH2_27294783_Chip-Seq_ESCs_Mouse1.26409966
60DNAJC2_21179169_ChIP-ChIP_NT2_Human1.25232030
61VDR_24787735_ChIP-Seq_THP-1_Human1.24529487
62RARB_27405468_Chip-Seq_BRAIN_Mouse1.22575836
63ZNF217_24962896_ChIP-Seq_MCF-7_Human1.20680945
64TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.19987237
65CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.19835842
66IKZF1_21737484_ChIP-ChIP_HCT116_Human1.17835768
67IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.17325343
68ESR1_21235772_ChIP-Seq_MCF-7_Human1.17269647
69GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17095446
70EGR1_19032775_ChIP-ChIP_M12_Human1.17021565
71POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15922373
72TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15922373
73OCT4_19829295_ChIP-Seq_ESCs_Human1.14725495
74CBX2_27304074_Chip-Seq_ESCs_Mouse1.13462699
75STAT6_21828071_ChIP-Seq_BEAS2B_Human1.13247983
76LXR_22158963_ChIP-Seq_LIVER_Mouse1.13109394
77THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.12825380
78RUNX1_27514584_Chip-Seq_MCF-7_Human1.11923992
79ERA_21632823_ChIP-Seq_H3396_Human1.11263225
80TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.10980652
81SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.10979658
82ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.10869897
83ARNT_22903824_ChIP-Seq_MCF-7_Human1.10019798
84RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.09567778
85PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.09387908
86MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.08890722
87* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07227678
88E2F1_20622854_ChIP-Seq_HELA_Human1.07156384
89ZNF274_21170338_ChIP-Seq_K562_Hela1.07084806
90STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.05419275
91RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.04113528
92RACK7_27058665_Chip-Seq_MCF-7_Human1.01446976
93SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01389228
94TP53_20018659_ChIP-ChIP_R1E_Mouse1.01194546
95BCOR_27268052_Chip-Seq_Bcells_Human1.01154742
96SOX9_24532713_ChIP-Seq_HFSC_Mouse1.01014416
97TP63_22573176_ChIP-Seq_HFKS_Human0.99893044
98SOX2_27498859_Chip-Seq_STOMACH_Mouse0.99591710
99ZFP281_27345836_Chip-Seq_ESCs_Mouse0.99386083
100SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99093089
101CBP_20019798_ChIP-Seq_JUKART_Human0.98941100
102IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98941100
103P63_26484246_Chip-Seq_KERATINOCYTES_Human0.98923094
104TP53_16413492_ChIP-PET_HCT116_Human0.98693809
105* RXR_22158963_ChIP-Seq_LIVER_Mouse0.98407376
106CTBP2_25329375_ChIP-Seq_LNCAP_Human0.98330806
107TET1_21490601_ChIP-Seq_MESCs_Mouse0.98112968
108FOXA2_19822575_ChIP-Seq_HepG2_Human0.97644443
109BCAT_22108803_ChIP-Seq_LS180_Human0.97524971
110SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97225431
111KLF4_19829295_ChIP-Seq_ESCs_Human0.96737466
112PIAS1_25552417_ChIP-Seq_VCAP_Human0.96686208
113PHF8_20622854_ChIP-Seq_HELA_Human0.96325944
114AR_19668381_ChIP-Seq_PC3_Human0.96048591
115BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95823270
116PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95274295
117IGF1R_20145208_ChIP-Seq_DFB_Human0.95153584
118EED_16625203_ChIP-ChIP_MESCs_Mouse0.95075435
119RING1B_27294783_Chip-Seq_NPCs_Mouse0.95054372
120OCT4_20526341_ChIP-Seq_ESCs_Human0.94920888
121EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.94558703
122WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93777892
123BCL6_27268052_Chip-Seq_Bcells_Human0.92694196
124SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.92251287
125NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.91706847
126PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.90637723
127CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.90367861
128KDM2B_26808549_Chip-Seq_SUP-B15_Human0.89941895
129EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.89127709
130STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.88264430
131ER_23166858_ChIP-Seq_MCF-7_Human0.88181580
132* KDM2B_26808549_Chip-Seq_K562_Human0.88057670
133EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.88008530
134MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87699448
135ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.87500970
136RARB_24833708_ChIP-Seq_LIVER_Mouse0.86714552
137WDR5_24793694_ChIP-Seq_LNCAP_Human0.86113462
138ISL1_27105846_Chip-Seq_CPCs_Mouse0.85884088
139TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85594390
140TCF4_22108803_ChIP-Seq_LS180_Human0.84871221
141RING1B_27294783_Chip-Seq_ESCs_Mouse0.84166660
142SMAD3_21741376_ChIP-Seq_HESCs_Human0.83951975
143GBX2_23144817_ChIP-Seq_PC3_Human0.83281812
144SOX2_20726797_ChIP-Seq_SW620_Human0.83015757
145Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.82623662
146NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.82266874
147TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.82201720
148TP53_18474530_ChIP-ChIP_U2OS_Human0.82061509
149P53_22127205_ChIP-Seq_FIBROBLAST_Human0.82026028
150TP63_23658742_ChIP-Seq_EP156T_Human0.81998524
151CJUN_26792858_Chip-Seq_BT549_Human0.80452300
152SMRT_27268052_Chip-Seq_Bcells_Human0.80340892
153* PPARA_22158963_ChIP-Seq_LIVER_Mouse0.79992241
154TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79283478
155RUNX_20019798_ChIP-Seq_JUKART_Human0.78950327
156CDX2_22108803_ChIP-Seq_LS180_Human0.78229586
157TBX20_22328084_ChIP-Seq_HEART_Mouse0.77749515
158TBX20_22080862_ChIP-Seq_HEART_Mouse0.77749515
159KLF5_25053715_ChIP-Seq_YYC3_Human0.77737264

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001348_abnormal_lacrimal_gland6.15151178
2MP0001346_abnormal_lacrimal_gland5.82013173
3MP0002876_abnormal_thyroid_physiology5.06944365
4MP0000685_abnormal_immune_system4.04587395
5MP0001873_stomach_inflammation3.73884771
6MP0005310_abnormal_salivary_gland3.49189295
7MP0003136_yellow_coat_color3.42968326
8MP0005645_abnormal_hypothalamus_physiol3.20740289
9MP0003880_abnormal_central_pattern2.85713512
10MP0006082_CNS_inflammation2.84949926
11MP0004859_abnormal_synaptic_plasticity2.67512330
12MP0004510_myositis2.60820338
13MP0001835_abnormal_antigen_presentation2.50174609
14MP0001968_abnormal_touch/_nociception2.47368299
15MP0005167_abnormal_blood-brain_barrier2.29792793
16MP0003879_abnormal_hair_cell2.19905279
17MP0002822_catalepsy2.18688562
18MP0002249_abnormal_larynx_morphology2.18398071
19MP0002653_abnormal_ependyma_morphology2.16364066
20MP0000566_synostosis2.09745860
21MP0005174_abnormal_tail_pigmentation2.09027596
22MP0005409_darkened_coat_color2.03910551
23MP0002254_reproductive_system_inflammat12.9239162
24MP0003635_abnormal_synaptic_transmissio1.99829347
25MP0004381_abnormal_hair_follicle1.97714897
26MP0005646_abnormal_pituitary_gland1.93226640
27MP0005647_abnormal_sex_gland1.87400972
28MP0002234_abnormal_pharynx_morphology1.85094855
29MP0002063_abnormal_learning/memory/cond1.85034163
30MP0002877_abnormal_melanocyte_morpholog1.82499802
31MP0001486_abnormal_startle_reflex1.80930384
32MP0003787_abnormal_imprinting1.78433082
33MP0006292_abnormal_olfactory_placode1.77018468
34MP0009745_abnormal_behavioral_response1.73388327
35MP0002138_abnormal_hepatobiliary_system1.73298887
36MP0002572_abnormal_emotion/affect_behav1.71732439
37MP0000015_abnormal_ear_pigmentation1.67402270
38MP0002064_seizures1.65609647
39MP0005423_abnormal_somatic_nervous1.65052181
40MP0005551_abnormal_eye_electrophysiolog1.61415221
41MP0002557_abnormal_social/conspecific_i1.60817049
42MP0000778_abnormal_nervous_system1.58981731
43MP0002272_abnormal_nervous_system1.56200725
44MP0000613_abnormal_salivary_gland1.52252914
45MP0009780_abnormal_chondrocyte_physiolo1.50553409
46MP0004043_abnormal_pH_regulation1.50444216
47MP0005671_abnormal_response_to1.49878056
48MP0001790_abnormal_immune_system1.46472741
49MP0005387_immune_system_phenotype1.46472741
50MP0005670_abnormal_white_adipose1.44147396
51MP0001851_eye_inflammation1.43074953
52MP0001986_abnormal_taste_sensitivity1.42611934
53MP0003283_abnormal_digestive_organ1.41067862
54MP0004133_heterotaxia1.37669455
55MP0009046_muscle_twitch1.37341250
56MP0000383_abnormal_hair_follicle1.36136103
57MP0010678_abnormal_skin_adnexa1.35356931
58MP0002735_abnormal_chemical_nociception1.34116353
59MP0003763_abnormal_thymus_physiology1.30595486
60MP0010234_abnormal_vibrissa_follicle1.28191391
61MP0004270_analgesia1.27806753
62MP0000013_abnormal_adipose_tissue1.27714685
63MP0001188_hyperpigmentation1.26597914
64MP0002277_abnormal_respiratory_mucosa1.26499685
65MP0002184_abnormal_innervation1.25668391
66MP0002736_abnormal_nociception_after1.23099826
67MP0003453_abnormal_keratinocyte_physiol1.21595424
68MP0006276_abnormal_autonomic_nervous1.20350061
69MP0005503_abnormal_tendon_morphology1.17929674
70MP0005075_abnormal_melanosome_morpholog1.15375964
71MP0000026_abnormal_inner_ear1.13760554
72MP0005058_abnormal_lysosome_morphology1.12468418
73MP0005377_hearing/vestibular/ear_phenot1.12357640
74MP0003878_abnormal_ear_physiology1.12357640
75MP0002909_abnormal_adrenal_gland1.11148790
76MP0001485_abnormal_pinna_reflex1.07467853
77MP0000470_abnormal_stomach_morphology1.05971669
78MP0003045_fibrosis1.02925854
79MP0000678_abnormal_parathyroid_gland1.01964767
80MP0003938_abnormal_ear_development1.01691844
81MP0003633_abnormal_nervous_system1.00973156
82MP0002882_abnormal_neuron_morphology1.00402593
83MP0000371_diluted_coat_color1.00209608
84MP0008057_abnormal_DNA_replication0.98711198
85MP0003123_paternal_imprinting0.98120930
86MP0002067_abnormal_sensory_capabilities0.96348080
87MP0001944_abnormal_pancreas_morphology0.96016989
88MP0002752_abnormal_somatic_nervous0.95839741
89MP0001501_abnormal_sleep_pattern0.95406022
90MP0000631_abnormal_neuroendocrine_gland0.94040859
91MP0001963_abnormal_hearing_physiology0.93645843
92MP0001984_abnormal_olfaction0.93000866
93MP0004742_abnormal_vestibular_system0.92818651
94MP0000955_abnormal_spinal_cord0.90487956
95MP0004145_abnormal_muscle_electrophysio0.87635388
96MP0005220_abnormal_exocrine_pancreas0.86976277
97MP0005000_abnormal_immune_tolerance0.85852640
98MP0000516_abnormal_urinary_system0.85751080
99MP0005367_renal/urinary_system_phenotyp0.85751080
100MP0002638_abnormal_pupillary_reflex0.85499814
101MP0004924_abnormal_behavior0.85471637
102MP0005386_behavior/neurological_phenoty0.85471637
103MP0002116_abnormal_craniofacial_bone0.85036355
104MP0001765_abnormal_ion_homeostasis0.84454485
105MP0001919_abnormal_reproductive_system0.83320720
106MP0003690_abnormal_glial_cell0.81188420
107MP0010352_gastrointestinal_tract_polyps0.81183709
108MP0010368_abnormal_lymphatic_system0.80885955
109MP0001664_abnormal_digestion0.79434508
110MP0003300_gastrointestinal_ulcer0.79330145
111MP0003183_abnormal_peptide_metabolism0.79288963
112MP0002229_neurodegeneration0.78459105
113MP0003631_nervous_system_phenotype0.76845855
114MP0002148_abnormal_hypersensitivity_rea0.76822165
115MP0001881_abnormal_mammary_gland0.76318739
116MP0001800_abnormal_humoral_immune0.75529405
117MP0002932_abnormal_joint_morphology0.75197094
118MP0003329_amyloid_beta_deposits0.74628398
119MP0000604_amyloidosis0.74574614
120MP0010155_abnormal_intestine_physiology0.74008020
121MP0005410_abnormal_fertilization0.73982495
122MP0002405_respiratory_system_inflammati0.73070051
123MP0002933_joint_inflammation0.72606680
124MP0002837_dystrophic_cardiac_calcinosis0.70742713
125MP0003195_calcinosis0.68728662
126MP0002693_abnormal_pancreas_physiology0.66543939
127MP0004782_abnormal_surfactant_physiolog0.66207243
128MP0000538_abnormal_urinary_bladder0.62929221
129MP0001663_abnormal_digestive_system0.62792121
130MP0005025_abnormal_response_to0.62737737
131MP0000579_abnormal_nail_morphology0.60695690
132MP0002733_abnormal_thermal_nociception0.60263654
133MP0001502_abnormal_circadian_rhythm0.59822327
134MP0003448_altered_tumor_morphology0.59319194
135MP0001845_abnormal_inflammatory_respons0.58848887
136MP0003091_abnormal_cell_migration0.58185245
137MP0009785_altered_susceptibility_to0.56855435
138MP0003638_abnormal_response/metabolism_0.53475611
139MP0005623_abnormal_meninges_morphology0.53455124
140MP0003075_altered_response_to0.53336111
141MP0004947_skin_inflammation0.51220670
142MP0002796_impaired_skin_barrier0.51201051
143MP0001853_heart_inflammation0.49248279
144MP0005381_digestive/alimentary_phenotyp0.49026382
145MP0004858_abnormal_nervous_system0.48567062
146MP0005197_abnormal_uvea_morphology0.47941686
147MP0008872_abnormal_physiological_respon0.47396891
148MP0002452_abnormal_antigen_presenting0.44971572
149MP0005076_abnormal_cell_differentiation0.43840544
150MP0009765_abnormal_xenobiotic_induced0.43318794
151MP0002723_abnormal_immune_serum0.42594565
152MP0002734_abnormal_mechanical_nocicepti0.42528911
153MP0003303_peritoneal_inflammation0.41423986
154MP0000703_abnormal_thymus_morphology0.40519401
155MP0000639_abnormal_adrenal_gland0.39640068
156MP0005535_abnormal_body_temperature0.39454993
157MP0001819_abnormal_immune_cell0.39119747
158MP0000627_abnormal_mammary_gland0.39072008
159MP0000920_abnormal_myelination0.38477864
160MP0000733_abnormal_muscle_development0.38465724
161MP0000716_abnormal_immune_system0.37045398
162MP0008569_lethality_at_weaning0.36756139
163MP0002420_abnormal_adaptive_immunity0.36699490
164MP0002971_abnormal_brown_adipose0.35340735
165MP0003436_decreased_susceptibility_to0.33824675
166MP0001216_abnormal_epidermal_layer0.33771431
167MP0003172_abnormal_lysosome_physiology0.33594903
168MP0004885_abnormal_endolymph0.32517960
169MP0008004_abnormal_stomach_pH0.31406756
170MP0002419_abnormal_innate_immunity0.31325332
171MP0002098_abnormal_vibrissa_morphology0.29551594
172MP0005451_abnormal_body_composition0.27930262
173MP0002970_abnormal_white_adipose0.26362248
174MP0001970_abnormal_pain_threshold0.25740032
175MP0009643_abnormal_urine_homeostasis0.25403959
176MP0001849_ear_inflammation0.25329105
177MP0009333_abnormal_splenocyte_physiolog0.25030452
178MP0005448_abnormal_energy_balance0.24720327
179MP0003828_pulmonary_edema0.23035297

Predicted human phenotypes

RankGene SetZ-score
1Recurrent cutaneous fungal infections (HP:0011370)9.80412806
2Chronic mucocutaneous candidiasis (HP:0002728)9.80412806
3Keratoconjunctivitis (HP:0001096)8.24731280
4Aplasia/Hypoplasia of the spleen (HP:0010451)8.21924773
5Asplenia (HP:0001746)7.50660154
6Abnormality of calcium-phosphate metabolism (HP:0100530)6.08611248
7Hypercortisolism (HP:0001578)5.77085326
8Type I diabetes mellitus (HP:0100651)5.39307196
9Recurrent fungal infections (HP:0002841)5.18540006
10Recurrent skin infections (HP:0001581)4.98548216
11Abnormality of the gastric mucosa (HP:0004295)4.93842776
12Increased IgE level (HP:0003212)4.53284370
13Cholelithiasis (HP:0001081)4.41729878
14Eczematoid dermatitis (HP:0000976)4.20039256
15Hypoparathyroidism (HP:0000829)4.10798564
16Abnormal gallbladder morphology (HP:0012437)4.07263818
17Upper limb muscle weakness (HP:0003484)4.07214238
18Hydroxyprolinuria (HP:0003080)4.05928808
19Abnormality of proline metabolism (HP:0010907)4.05928808
20Right ventricular cardiomyopathy (HP:0011663)3.95588761
21Type 2 muscle fiber atrophy (HP:0003554)3.91013200
22Type II lissencephaly (HP:0007260)3.89591457
23Lymphangioma (HP:0100764)3.86527635
24Obstructive sleep apnea (HP:0002870)3.86420335
25Hypoplasia of dental enamel (HP:0006297)3.78797466
26Hepatitis (HP:0012115)3.67181672
27Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.64144300
28Keratitis (HP:0000491)3.59480909
29Genetic anticipation (HP:0003743)3.49981511
30Abnormal pupillary function (HP:0007686)3.48052611
31Muscle fiber atrophy (HP:0100295)3.46407783
32J-shaped sella turcica (HP:0002680)3.43835431
33Fatigable weakness (HP:0003473)3.37886253
34Abnormality of the neuromuscular junction (HP:0003398)3.37886253
35Thin bony cortex (HP:0002753)3.37133483
36Abnormal delayed hypersensitivity skin test (HP:0002963)3.37087826
37Onycholysis (HP:0001806)3.32070819
38Hypoplastic ischia (HP:0003175)3.31107130
39Plantar hyperkeratosis (HP:0007556)3.24863564
40Unilateral renal agenesis (HP:0000122)3.24600039
41Colitis (HP:0002583)3.22215614
42Abnormal auditory evoked potentials (HP:0006958)3.09448353
43Congenital stationary night blindness (HP:0007642)3.09132542
44Progressive cerebellar ataxia (HP:0002073)3.07190248
45Decreased number of large peripheral myelinated nerve fibers (HP:0003387)3.02006844
46Cerebellar dysplasia (HP:0007033)3.01026410
47Lip pit (HP:0100267)2.97285394
48Neurofibrillary tangles (HP:0002185)2.90971683
49Onion bulb formation (HP:0003383)2.89899279
50Inflammation of the large intestine (HP:0002037)2.85128742
51Weak cry (HP:0001612)2.84658030
52Abnormality of the ischium (HP:0003174)2.84109271
53Adrenal overactivity (HP:0002717)2.80010476
54Tongue fasciculations (HP:0001308)2.79149783
55Interstitial pulmonary disease (HP:0006530)2.76564968
56Palmoplantar hyperkeratosis (HP:0000972)2.71078064
57Nasal polyposis (HP:0100582)2.69181422
58Vitreoretinal degeneration (HP:0000655)2.69123364
59Chronic otitis media (HP:0000389)2.64465265
60Abnormality of the gallbladder (HP:0005264)2.63592023
61Agammaglobulinemia (HP:0004432)2.63334952
62Neoplasm of the heart (HP:0100544)2.63318645
63Amelogenesis imperfecta (HP:0000705)2.63061277
64Gastrointestinal inflammation (HP:0004386)2.57865514
65Cystic liver disease (HP:0006706)2.57095191
66Pustule (HP:0200039)2.56983867
67Prolonged neonatal jaundice (HP:0006579)2.55795045
68Abnormality of mucopolysaccharide metabolism (HP:0011020)2.55322325
69Abnormality of polysaccharide metabolism (HP:0011012)2.55322325
70Abnormality of glycosaminoglycan metabolism (HP:0004371)2.55322325
71Septo-optic dysplasia (HP:0100842)2.53371381
72Muscle fibrillation (HP:0010546)2.52864538
73Confusion (HP:0001289)2.52422573
74Palmar hyperkeratosis (HP:0010765)2.50614498
75Abnormality of the fingertips (HP:0001211)2.49015836
76Abnormality of small intestinal villus morphology (HP:0011472)2.47644615
77Villous atrophy (HP:0011473)2.47644615
78Milia (HP:0001056)2.47295017
79Abnormality of glutamine family amino acid metabolism (HP:0010902)2.46469172
80Urinary glycosaminoglycan excretion (HP:0003541)2.46442785
81Mucopolysacchariduria (HP:0008155)2.46442785
82Myokymia (HP:0002411)2.46007058
83Ocular albinism (HP:0001107)2.45995471
84Panhypogammaglobulinemia (HP:0003139)2.44878299
85Broad face (HP:0000283)2.41263115
86Tetraparesis (HP:0002273)2.41049842
87Cervical subluxation (HP:0003308)2.41040796
88Focal seizures (HP:0007359)2.38268726
89Large for gestational age (HP:0001520)2.38028844
90Cerebral inclusion bodies (HP:0100314)2.36805431
91Rib fusion (HP:0000902)2.36601297
92Annular pancreas (HP:0001734)2.34317646
93Prolonged QT interval (HP:0001657)2.31462530
94Nephronophthisis (HP:0000090)2.29472568
95Papilledema (HP:0001085)2.27929447
96Attenuation of retinal blood vessels (HP:0007843)2.24295765
97Hyperventilation (HP:0002883)2.22253257
98Abnormal rod and cone electroretinograms (HP:0008323)2.20630423
99Bronchomalacia (HP:0002780)2.19686142
100Easy fatigability (HP:0003388)2.18773183
101Febrile seizures (HP:0002373)2.15980335
102Premature loss of primary teeth (HP:0006323)2.15920747
103Hypoplasia of the uterus (HP:0000013)2.15562443
104Ketoacidosis (HP:0001993)2.14798333
105Renal dysplasia (HP:0000110)2.11198276
106Iris hypopigmentation (HP:0007730)2.11052553
107Abnormality of the nasal mucosa (HP:0000433)2.10270485
108Abnormality of the renal medulla (HP:0100957)2.09335388
109Gaze-evoked nystagmus (HP:0000640)2.08934366
110Severe muscular hypotonia (HP:0006829)2.08926771
111Abnormality of the vitreous humor (HP:0004327)2.08783622
112Tented upper lip vermilion (HP:0010804)2.08671596
113Supranuclear gaze palsy (HP:0000605)2.05356187
114Mesangial abnormality (HP:0001966)2.04948864
115Testicular atrophy (HP:0000029)2.04721532
116Retinal dysplasia (HP:0007973)2.03402494
117Hamartoma of the eye (HP:0010568)2.02952960
118Germ cell neoplasia (HP:0100728)2.01256512
119Concave nail (HP:0001598)2.01009209
120Xerostomia (HP:0000217)2.00921194
121Spinal canal stenosis (HP:0003416)2.00682643
122Abnormality of the pubic bones (HP:0003172)1.98352833
123Impaired smooth pursuit (HP:0007772)1.96402834
124Hypoplasia of the odontoid process (HP:0003311)1.96175559
125Gingivitis (HP:0000230)1.95719359
126Sleep apnea (HP:0010535)1.95595875
127Stridor (HP:0010307)1.95055018
128Dysostosis multiplex (HP:0000943)1.94642024
129Gastrointestinal stroma tumor (HP:0100723)1.94641094
130Depressed nasal tip (HP:0000437)1.94638722
131Decreased muscle mass (HP:0003199)1.94172211
132Tubular atrophy (HP:0000092)1.93433296
133Broad metatarsal (HP:0001783)1.93391237
134Sparse lateral eyebrow (HP:0005338)1.93030543
135Clumsiness (HP:0002312)1.92973953
136Hypergammaglobulinemia (HP:0010702)1.87863787
137Truncus arteriosus (HP:0001660)1.87818699
138Bony spicule pigmentary retinopathy (HP:0007737)1.85748341
139Severe visual impairment (HP:0001141)1.85391064
140Atonic seizures (HP:0010819)1.85087933
141Pancreatic cysts (HP:0001737)1.85047866
142Ependymoma (HP:0002888)1.84399848
143Deformed sella turcica (HP:0002681)1.84132105
144Urticaria (HP:0001025)1.83299691
145Abnormality of macrophages (HP:0004311)1.82915254
146Absent speech (HP:0001344)1.82844244
147Emphysema (HP:0002097)1.82835607
148Ketosis (HP:0001946)1.81979182
149Anal stenosis (HP:0002025)1.81593509
150Visceral angiomatosis (HP:0100761)1.81438393
151Congenital malformation of the right heart (HP:0011723)1.81043705
152Double outlet right ventricle (HP:0001719)1.81043705
153Gait imbalance (HP:0002141)1.80964194
154Epileptic encephalopathy (HP:0200134)1.79399533
155Buphthalmos (HP:0000557)1.79238520
156Recurrent bacterial skin infections (HP:0005406)1.77538708
157Abnormality of the femoral head (HP:0003368)1.77133425
158Primary adrenal insufficiency (HP:0008207)1.75241989
159Recurrent gram-negative bacterial infections (HP:0005420)1.73168624
160Enlarged penis (HP:0000040)1.71833126
161Hemiparesis (HP:0001269)1.71409464
162Bulbous nose (HP:0000414)1.71229959
163Agitation (HP:0000713)1.71223585
164Occipital encephalocele (HP:0002085)1.70620373
165Atrophic scars (HP:0001075)1.70328870
166Abnormality of placental membranes (HP:0011409)1.69283090
167Amniotic constriction ring (HP:0009775)1.69283090
168Ankle clonus (HP:0011448)1.68944048
169Enlarged epiphyses (HP:0010580)1.68855929
170Maternal diabetes (HP:0009800)1.68742041
171Abnormal drinking behavior (HP:0030082)1.67703585
172Polydipsia (HP:0001959)1.67703585
173Intellectual disability, severe (HP:0010864)1.66998940
174Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.66662458
175Viral hepatitis (HP:0006562)1.66075260
176Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.64656035
177Macroorchidism (HP:0000053)1.64267878
178Syncope (HP:0001279)1.63414760
179Fragile nails (HP:0001808)1.63291941
180Abnormal EKG (HP:0003115)1.63274680
181Medial flaring of the eyebrow (HP:0010747)1.63112022
182Neonatal hypoglycemia (HP:0001998)1.61705470
183Hypohidrosis (HP:0000966)1.61474574
184Molar tooth sign on MRI (HP:0002419)1.59503737
185Abnormality of midbrain morphology (HP:0002418)1.59503737
186Tracheomalacia (HP:0002779)1.58984801
187Recurrent lower respiratory tract infections (HP:0002783)1.55997369
188Peripheral demyelination (HP:0011096)1.55884607
189Woolly hair (HP:0002224)1.55741510
190Mediastinal lymphadenopathy (HP:0100721)1.52503457
191Fragile skin (HP:0001030)1.50728203
192Conical tooth (HP:0000698)1.50501467
193Anosmia (HP:0000458)1.50205956
194Reticulocytosis (HP:0001923)1.49360981
195Abnormality of the aortic arch (HP:0012303)1.48567544
196Aplasia/hypoplasia of the uterus (HP:0008684)1.46753253
197Periodontitis (HP:0000704)1.46129495

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K146.81928499
2EPHA35.29366216
3EPHB14.25375234
4NME13.96827735
5DYRK33.49073787
6TNK23.45802986
7FRK3.41610813
8FGFR43.33989970
9NTRK33.21750805
10PRKD32.78094395
11WNK42.66392433
12MAP3K132.58817571
13EPHA22.35710634
14FGFR22.29974263
15TRIB32.19201390
16PINK12.16354495
17CHUK2.15732228
18NLK2.09368339
19CDC42BPA1.94098419
20CAMK1D1.82723745
21IKBKB1.82100729
22MARK21.81820354
23PKN21.81565269
24PTK61.74132104
25IKBKE1.72467823
26TYK21.70535765
27JAK31.69359140
28MAP2K61.67098537
29IRAK41.66550457
30TBK11.64940283
31GRK11.63850984
32MAP3K71.63687705
33EPHA41.61842298
34BMPR1B1.61203095
35MAPK151.60755268
36CASK1.59050969
37IRAK11.57287290
38MAP3K91.56408789
39NTRK21.54402209
40MUSK1.53176140
41FGFR31.51328988
42PRKD21.49552056
43AKT31.47643346
44JAK11.40820048
45FER1.40701364
46RIPK11.39117779
47CAMK1G1.38995794
48ITK1.32580669
49MAPK131.28471790
50GRK51.27751401
51PRKCI1.22902290
52DYRK1B1.20829976
53BCR1.20230552
54WNK11.19289874
55SIK21.18788644
56DDR21.17739102
57SGK2231.12680833
58SGK4941.12680833
59JAK21.12509795
60PKN11.12155935
61SGK21.11851513
62PTK21.11799744
63RPS6KA21.10124804
64PRKCH1.09515695
65CAMK11.08272222
66MARK11.08155414
67INSRR1.05422508
68CAMKK11.03203891
69BTK1.01810268
70EEF2K1.00215346
71STK390.99445992
72MAP3K60.98443705
73CLK10.97806883
74MST40.91681950
75PHKG10.91250405
76PHKG20.91250405
77PRKAA10.90211351
78MAPKAPK50.89967500
79IRAK30.88220716
80MATK0.87449911
81MAP2K20.85920254
82RPS6KA60.85601411
83TGFBR10.85585047
84CSNK1A1L0.82003497
85ADRBK20.81986993
86CSNK1G10.79975995
87PRKAA20.78615485
88TSSK60.75791864
89SGK30.74695363
90MAP3K100.73898479
91PTK2B0.73745840
92DYRK1A0.71180593
93KDR0.69371082
94CSNK1G30.68101601
95RPS6KL10.66796304
96RPS6KC10.66796304
97ROCK20.66384729
98HIPK20.66047477
99DAPK20.64270034
100PRKCG0.63450252
101MAP2K40.62062281
102CAMK40.62032382
103EIF2AK20.61440824
104NTRK10.60825204
105ALK0.59648926
106CSNK1G20.58504779
107SCYL20.58011753
108TIE10.57808541
109ICK0.57658456
110RET0.57485963
111CDK90.57260109
112LRRK20.56587775
113MINK10.55937583
114TAOK10.53688752
115CDK50.53478015
116SYK0.52529144
117PRKDC0.51163867
118BMX0.51001692
119MAP3K20.50937964
120BMPR20.50420070
121MAPKAPK30.50034017
122ERBB30.49785069
123PRKCQ0.49607035
124HCK0.49509344
125STK380.48603463
126STK110.47963743
127ACVR1B0.47830761
128TYRO30.45775851
129STK100.44569916
130MAP2K70.44397536
131SRC0.43902633
132MAP4K20.42511130
133MAP3K10.41332779
134MAPK120.40246422
135PDK10.40028367
136MAPK70.39311807
137TNIK0.39027577
138MAP3K40.38763185
139PDPK10.38733408
140PRKD10.38336123
141CDK30.38133121
142KIT0.37797638
143ERBB20.37738527
144WNK30.37423551
145ADRBK10.36008848
146RPS6KA50.35772891
147SIK10.35118920
148PRKCE0.34964875
149CDK80.33192593
150PRKCD0.32768582
151TEC0.32740089
152DYRK20.32072686
153FGR0.31729633
154PDGFRA0.31483951
155MAPKAPK20.30695443
156EGFR0.28873788
157MTOR0.28259432
158CAMK2G0.28196295
159MAP2K10.27994179
160PRKCZ0.26804327
161RPS6KB20.26522607
162PAK30.24640972
163MAPK80.23819958
164LCK0.23323654
165CSK0.22920640
166KSR20.22557854
167GSK3A0.21955560
168INSR0.21072471
169SGK10.19513049
170CAMK2B0.18060393
171OXSR10.17660479
172RPS6KA10.17553376
173PAK60.17258703

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004006.14177158
2Primary immunodeficiency_Homo sapiens_hsa053404.23693429
3Histidine metabolism_Homo sapiens_hsa003403.62959701
4Antigen processing and presentation_Homo sapiens_hsa046123.00600088
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.58811605
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.46800310
7Insulin secretion_Homo sapiens_hsa049112.26102813
8Leishmaniasis_Homo sapiens_hsa051402.00647238
9Phototransduction_Homo sapiens_hsa047441.97905447
10Glycosaminoglycan degradation_Homo sapiens_hsa005311.88570088
11Notch signaling pathway_Homo sapiens_hsa043301.87655827
12Allograft rejection_Homo sapiens_hsa053301.82395892
13Phenylalanine metabolism_Homo sapiens_hsa003601.81873139
14Aldosterone synthesis and secretion_Homo sapiens_hsa049251.80604415
15Asthma_Homo sapiens_hsa053101.79380701
16Arginine biosynthesis_Homo sapiens_hsa002201.78194371
17Other glycan degradation_Homo sapiens_hsa005111.77155347
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.76089773
19African trypanosomiasis_Homo sapiens_hsa051431.62862995
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.55184609
21Osteoclast differentiation_Homo sapiens_hsa043801.55056218
22Autoimmune thyroid disease_Homo sapiens_hsa053201.49196376
23Toxoplasmosis_Homo sapiens_hsa051451.48037754
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.45782198
25Lysine degradation_Homo sapiens_hsa003101.45104264
26Taste transduction_Homo sapiens_hsa047421.42764888
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.40998891
28Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.39995778
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.35190762
30Axon guidance_Homo sapiens_hsa043601.30376635
31Vascular smooth muscle contraction_Homo sapiens_hsa042701.30121005
32Linoleic acid metabolism_Homo sapiens_hsa005911.28867809
33Dopaminergic synapse_Homo sapiens_hsa047281.28860182
34Ovarian steroidogenesis_Homo sapiens_hsa049131.28391690
35Synaptic vesicle cycle_Homo sapiens_hsa047211.27005919
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.25965781
37Renin secretion_Homo sapiens_hsa049241.24334572
38Graft-versus-host disease_Homo sapiens_hsa053321.24143824
39Cholinergic synapse_Homo sapiens_hsa047251.23488296
40Oxytocin signaling pathway_Homo sapiens_hsa049211.22877912
41cAMP signaling pathway_Homo sapiens_hsa040241.22047739
42Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.19898484
43Longevity regulating pathway - mammal_Homo sapiens_hsa042111.19161824
44Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.18300151
45Tryptophan metabolism_Homo sapiens_hsa003801.15022807
46Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.14655290
47Cyanoamino acid metabolism_Homo sapiens_hsa004601.14634393
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.12810865
49Small cell lung cancer_Homo sapiens_hsa052221.07278585
50TNF signaling pathway_Homo sapiens_hsa046681.05966977
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.04285494
52Melanogenesis_Homo sapiens_hsa049161.03860887
53mTOR signaling pathway_Homo sapiens_hsa041501.03838397
54Butanoate metabolism_Homo sapiens_hsa006501.02982130
55Long-term depression_Homo sapiens_hsa047301.02767236
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.01119276
57Phospholipase D signaling pathway_Homo sapiens_hsa040721.00668641
58Estrogen signaling pathway_Homo sapiens_hsa049151.00428905
59Bile secretion_Homo sapiens_hsa049760.99916162
60Ether lipid metabolism_Homo sapiens_hsa005650.99698037
61Amphetamine addiction_Homo sapiens_hsa050310.99010286
62cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98430132
63AMPK signaling pathway_Homo sapiens_hsa041520.98101133
64Choline metabolism in cancer_Homo sapiens_hsa052310.97969124
65Chemokine signaling pathway_Homo sapiens_hsa040620.97644544
66GnRH signaling pathway_Homo sapiens_hsa049120.95262848
67Regulation of autophagy_Homo sapiens_hsa041400.94016428
68Circadian rhythm_Homo sapiens_hsa047100.93489784
69Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.88952805
70ABC transporters_Homo sapiens_hsa020100.88798090
71Tuberculosis_Homo sapiens_hsa051520.87991511
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87902154
73Pancreatic secretion_Homo sapiens_hsa049720.86891285
74Hedgehog signaling pathway_Homo sapiens_hsa043400.86876591
75RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.86526473
76Inositol phosphate metabolism_Homo sapiens_hsa005620.86209174
77Fatty acid biosynthesis_Homo sapiens_hsa000610.85125430
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81857822
79Pertussis_Homo sapiens_hsa051330.80844544
80Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.79849184
81Long-term potentiation_Homo sapiens_hsa047200.79645626
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.79529159
83Vitamin digestion and absorption_Homo sapiens_hsa049770.77988517
84Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.77872824
85Rheumatoid arthritis_Homo sapiens_hsa053230.77871863
86Glucagon signaling pathway_Homo sapiens_hsa049220.77558026
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77395264
88Apoptosis_Homo sapiens_hsa042100.77368773
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76844735
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74963006
91Collecting duct acid secretion_Homo sapiens_hsa049660.74142649
92Nicotine addiction_Homo sapiens_hsa050330.73997137
93Arginine and proline metabolism_Homo sapiens_hsa003300.73669389
94B cell receptor signaling pathway_Homo sapiens_hsa046620.72864864
95Dorso-ventral axis formation_Homo sapiens_hsa043200.72458833
96Legionellosis_Homo sapiens_hsa051340.72271144
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.72229612
98Type I diabetes mellitus_Homo sapiens_hsa049400.71855533
99Thyroid hormone synthesis_Homo sapiens_hsa049180.71484487
100Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70971749
101Insulin resistance_Homo sapiens_hsa049310.69511421
102Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.69501544
103Toll-like receptor signaling pathway_Homo sapiens_hsa046200.67783484
104Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67201776
105Olfactory transduction_Homo sapiens_hsa047400.66719335
106Cocaine addiction_Homo sapiens_hsa050300.66711751
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66114640
108Tyrosine metabolism_Homo sapiens_hsa003500.65702854
109Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63892594
110Insulin signaling pathway_Homo sapiens_hsa049100.63468889
111Leukocyte transendothelial migration_Homo sapiens_hsa046700.63236711
112Prolactin signaling pathway_Homo sapiens_hsa049170.63216544
113Serotonergic synapse_Homo sapiens_hsa047260.62759575
114Arachidonic acid metabolism_Homo sapiens_hsa005900.61564234
115Sphingolipid metabolism_Homo sapiens_hsa006000.61382295
116Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.61265156
117Measles_Homo sapiens_hsa051620.60991148
118Amoebiasis_Homo sapiens_hsa051460.60629270
119Glycerolipid metabolism_Homo sapiens_hsa005610.60329723
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.59618425
121Rap1 signaling pathway_Homo sapiens_hsa040150.58351311
122Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58062544
123Neurotrophin signaling pathway_Homo sapiens_hsa047220.56750167
124Pancreatic cancer_Homo sapiens_hsa052120.54713795
125Malaria_Homo sapiens_hsa051440.52301260
126Lysosome_Homo sapiens_hsa041420.52150741
127ErbB signaling pathway_Homo sapiens_hsa040120.51841442
128Nitrogen metabolism_Homo sapiens_hsa009100.50642721
129MAPK signaling pathway_Homo sapiens_hsa040100.47787544
130Salivary secretion_Homo sapiens_hsa049700.47315668
131Hippo signaling pathway_Homo sapiens_hsa043900.47134331
132Primary bile acid biosynthesis_Homo sapiens_hsa001200.46002227
133Glioma_Homo sapiens_hsa052140.45115363
134Calcium signaling pathway_Homo sapiens_hsa040200.44937376
135VEGF signaling pathway_Homo sapiens_hsa043700.44647081
136Mineral absorption_Homo sapiens_hsa049780.44616488
137Glutamatergic synapse_Homo sapiens_hsa047240.44446502
138Influenza A_Homo sapiens_hsa051640.43676600
139T cell receptor signaling pathway_Homo sapiens_hsa046600.43336099
140Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42937041
141Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.42852138
142Staphylococcus aureus infection_Homo sapiens_hsa051500.41577088
143Pathways in cancer_Homo sapiens_hsa052000.41110570
144AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.37628466
145Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.37092094
146Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36856840
147Cysteine and methionine metabolism_Homo sapiens_hsa002700.36161676
148Viral myocarditis_Homo sapiens_hsa054160.35027987
149Type II diabetes mellitus_Homo sapiens_hsa049300.34841843
150Basal cell carcinoma_Homo sapiens_hsa052170.33892421
151Ras signaling pathway_Homo sapiens_hsa040140.33873692
152Hepatitis C_Homo sapiens_hsa051600.33857329
153HTLV-I infection_Homo sapiens_hsa051660.33805948
154Sphingolipid signaling pathway_Homo sapiens_hsa040710.32580375
155Glycerophospholipid metabolism_Homo sapiens_hsa005640.31998961
156MicroRNAs in cancer_Homo sapiens_hsa052060.29747275
157Circadian entrainment_Homo sapiens_hsa047130.29427987
158Morphine addiction_Homo sapiens_hsa050320.29059818
159Gastric acid secretion_Homo sapiens_hsa049710.28710176
160Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.28656295
161Acute myeloid leukemia_Homo sapiens_hsa052210.28247463
162Hepatitis B_Homo sapiens_hsa051610.26273160
163GABAergic synapse_Homo sapiens_hsa047270.25953829
164Herpes simplex infection_Homo sapiens_hsa051680.25701354
165ECM-receptor interaction_Homo sapiens_hsa045120.25046984

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