SRXN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1low-density lipoprotein particle clearance (GO:0034383)4.57966049
2glycosphingolipid catabolic process (GO:0046479)4.14581262
3polyketide metabolic process (GO:0030638)4.10551132
4doxorubicin metabolic process (GO:0044598)4.10551132
5daunorubicin metabolic process (GO:0044597)4.10551132
6oligosaccharide catabolic process (GO:0009313)3.96423690
7glycolipid catabolic process (GO:0019377)3.88377682
8Golgi transport vesicle coating (GO:0048200)3.85634129
9COPI coating of Golgi vesicle (GO:0048205)3.85634129
10positive regulation of chemokine biosynthetic process (GO:0045080)3.74926241
11positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.59813466
12aminoglycoside antibiotic metabolic process (GO:0030647)3.53778707
13cellular response to thyroid hormone stimulus (GO:0097067)3.44172347
14barbed-end actin filament capping (GO:0051016)3.37553186
15pentose-phosphate shunt (GO:0006098)3.34395086
16regulation of vitamin D biosynthetic process (GO:0060556)3.33835441
17positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.30974756
18ceramide catabolic process (GO:0046514)3.30146593
19positive regulation of extracellular matrix organization (GO:1903055)3.29203612
20pinocytosis (GO:0006907)3.27720176
21regulation of vitamin metabolic process (GO:0030656)3.24819270
22glycoside metabolic process (GO:0016137)3.24297644
23skin morphogenesis (GO:0043589)3.22457245
24plasma lipoprotein particle clearance (GO:0034381)3.21038978
25negative regulation of interleukin-12 production (GO:0032695)3.14217293
26response to thyroid hormone (GO:0097066)3.11151941
27membrane lipid catabolic process (GO:0046466)3.08414462
28positive regulation by symbiont of host defense response (GO:0052509)3.05528872
29modulation by symbiont of host defense response (GO:0052031)3.05528872
30modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.05528872
31modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.05528872
32positive regulation by organism of defense response of other organism involved in symbiotic interact3.05528872
33modulation by symbiont of host immune response (GO:0052553)3.05528872
34NADPH regeneration (GO:0006740)3.03474467
35stress fiber assembly (GO:0043149)3.03201649
36regulation of membrane protein ectodomain proteolysis (GO:0051043)3.02347542
37hydrogen peroxide biosynthetic process (GO:0050665)3.00163427
38positive regulation of heat generation (GO:0031652)2.99383940
39macroautophagy (GO:0016236)2.97669787
40neutrophil activation involved in immune response (GO:0002283)2.96462734
41cysteine metabolic process (GO:0006534)2.94205158
42glucose 6-phosphate metabolic process (GO:0051156)2.90741138
43iron ion import (GO:0097286)2.88359655
44hemidesmosome assembly (GO:0031581)2.86896394
45regulation of fever generation (GO:0031620)2.84397198
46macrophage activation involved in immune response (GO:0002281)2.84015483
47decidualization (GO:0046697)2.82634056
48antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.82630913
49progesterone metabolic process (GO:0042448)2.82562299
50detection of molecule of bacterial origin (GO:0032490)2.82412470
51hyaluronan catabolic process (GO:0030214)2.81317731
52sphingolipid catabolic process (GO:0030149)2.81226820
53cyclooxygenase pathway (GO:0019371)2.81068025
54protein localization to endosome (GO:0036010)2.80731943
55negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.80479389
56aldehyde catabolic process (GO:0046185)2.80355425
57phagosome maturation (GO:0090382)2.79555097
58regulation of cholesterol storage (GO:0010885)2.78183820
59negative regulation of protein localization to plasma membrane (GO:1903077)2.71984648
60NIK/NF-kappaB signaling (GO:0038061)2.71032273
61regulation of superoxide anion generation (GO:0032928)2.70951696
62regulation of chemokine biosynthetic process (GO:0045073)2.70138740
63regulation of heterotypic cell-cell adhesion (GO:0034114)2.66973062
64response to laminar fluid shear stress (GO:0034616)2.65954921
65positive regulation of leukocyte degranulation (GO:0043302)2.65130316
66positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.63048049
67membrane raft organization (GO:0031579)2.62837331
68glucose catabolic process (GO:0006007)2.62698329
69positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.62289994
70epithelial cell-cell adhesion (GO:0090136)2.60822105
71maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.55680829
72regulation of mononuclear cell migration (GO:0071675)2.55589605
73positive regulation of p38MAPK cascade (GO:1900745)2.54952496
74positive regulation of endothelial cell apoptotic process (GO:2000353)2.54705999
75positive regulation of Cdc42 GTPase activity (GO:0043089)2.53604863
76hypotonic response (GO:0006971)2.53441211
77eosinophil chemotaxis (GO:0048245)2.51770238
78lipopolysaccharide-mediated signaling pathway (GO:0031663)2.51221048
79cellular copper ion homeostasis (GO:0006878)2.50521593
80negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.49291254
81amino sugar catabolic process (GO:0046348)2.49124224
82reactive oxygen species biosynthetic process (GO:1903409)2.48280041
83regulation of podosome assembly (GO:0071801)2.47847052
84negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.46558877
85mammary gland epithelial cell proliferation (GO:0033598)2.46284828
86cellular response to arsenic-containing substance (GO:0071243)2.46210143
87positive regulation of lipid storage (GO:0010884)2.43704068
88triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.43694666
89nucleobase-containing small molecule interconversion (GO:0015949)2.42953534
90negative regulation of amino acid transport (GO:0051956)2.42941513
91regulation of leukocyte degranulation (GO:0043300)2.42446544
92activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.41239862
93apoptotic cell clearance (GO:0043277)2.41109640
94positive regulation of fatty acid biosynthetic process (GO:0045723)2.40654300
95cofactor catabolic process (GO:0051187)2.38440643
96acute-phase response (GO:0006953)2.37608355
97osteoclast differentiation (GO:0030316)2.37385018
98respiratory burst (GO:0045730)2.36938823
99growth hormone receptor signaling pathway (GO:0060396)2.36859373
100epithelial cell differentiation involved in prostate gland development (GO:0060742)2.36218603
101protein retention in ER lumen (GO:0006621)2.36099215
102lipoprotein transport (GO:0042953)2.35464326
103regulation of macrophage chemotaxis (GO:0010758)2.35163217
104L-ascorbic acid metabolic process (GO:0019852)2.34213181
105modulation by symbiont of host cellular process (GO:0044068)2.33760664
106positive regulation of cellular amide metabolic process (GO:0034250)2.32977203
107cell-substrate junction assembly (GO:0007044)2.32803184
108negative regulation of erythrocyte differentiation (GO:0045647)2.32586312
109positive regulation of monocyte chemotaxis (GO:0090026)2.32106602
110phospholipid efflux (GO:0033700)2.31752392
111endoplasmic reticulum unfolded protein response (GO:0030968)2.30367002
112negative regulation of response to reactive oxygen species (GO:1901032)2.29812171
113positive regulation of nuclease activity (GO:0032075)2.28762085
114regulation of early endosome to late endosome transport (GO:2000641)2.28698663
115response to manganese ion (GO:0010042)2.28444050
116response to peptidoglycan (GO:0032494)2.27345176
117ER-nucleus signaling pathway (GO:0006984)2.26506173
118proline transport (GO:0015824)2.26113917
119regulation of cytokine secretion involved in immune response (GO:0002739)2.25555360
120response to progesterone (GO:0032570)2.25313039
121regulation of cholesterol homeostasis (GO:2000188)2.25095401
122eosinophil migration (GO:0072677)2.24627260
123substrate-dependent cell migration (GO:0006929)2.24375802
124regulation of metalloenzyme activity (GO:0048552)2.24337137
125cholesterol efflux (GO:0033344)2.23790271
126retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.23762495
127positive regulation of bone remodeling (GO:0046852)2.23502776
128positive regulation of bone resorption (GO:0045780)2.23502776
129protein-lipid complex assembly (GO:0065005)2.22630846
130negative regulation of lipid storage (GO:0010888)2.22064113
131negative regulation of cytokine production involved in immune response (GO:0002719)2.21902475
132L-alpha-amino acid transmembrane transport (GO:1902475)2.20171947
133fructose metabolic process (GO:0006000)2.18783313
134phagocytosis, recognition (GO:0006910)2.18774514
135positive regulation of interferon-alpha production (GO:0032727)2.18429507
136protein carboxylation (GO:0018214)2.17817455
137peptidyl-glutamic acid carboxylation (GO:0017187)2.17817455
138superoxide anion generation (GO:0042554)2.15871114
139regulation of heat generation (GO:0031650)2.15804869
140natural killer cell mediated immunity (GO:0002228)2.15595547
141natural killer cell mediated cytotoxicity (GO:0042267)2.15595547
142wound healing, spreading of epidermal cells (GO:0035313)2.15289963
143cell adhesion mediated by integrin (GO:0033627)2.14871841
144negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.14865731
145sexual reproduction (GO:0019953)2.13984838
146positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.13923638
147regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.12625419
148positive regulation of nitric oxide biosynthetic process (GO:0045429)2.11424115
149plasma lipoprotein particle assembly (GO:0034377)2.11121142
150transferrin transport (GO:0033572)2.11051186
151glucuronate metabolic process (GO:0019585)2.09429279
152uronic acid metabolic process (GO:0006063)2.09429279
153positive regulation of lipid catabolic process (GO:0050996)2.09392394
154alanine transport (GO:0032328)2.09267821
155regulation of interferon-beta biosynthetic process (GO:0045357)2.08252215
156regulation of interferon-alpha production (GO:0032647)2.07808381
157fibrinolysis (GO:0042730)2.07544605
158urea cycle (GO:0000050)2.05254158
159urea metabolic process (GO:0019627)2.05254158
160cellular response to nicotine (GO:0071316)2.04670067
161cellular response to ATP (GO:0071318)2.04237145
162cellular response to growth hormone stimulus (GO:0071378)2.03738856
163response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.03489217
164response to host immune response (GO:0052572)2.03489217
165granulocyte activation (GO:0036230)2.02776975
166regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.02729793
167trivalent inorganic cation transport (GO:0072512)2.02465751
168ferric iron transport (GO:0015682)2.02465751
169response to arsenic-containing substance (GO:0046685)2.02392927
170ATP hydrolysis coupled proton transport (GO:0015991)2.01624057
171energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.01624057

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.49294919
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.33813406
3IRF8_22096565_ChIP-ChIP_GC-B_Human2.84480222
4IRF8_21731497_ChIP-ChIP_J774_Mouse2.70189753
5TRIM28_21343339_ChIP-Seq_HEK293_Human2.66514518
6RXR_22158963_ChIP-Seq_LIVER_Mouse2.62504681
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.39544404
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.36577800
9LXR_22158963_ChIP-Seq_LIVER_Mouse2.35532809
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.32170253
11ZNF263_19887448_ChIP-Seq_K562_Human2.30602381
12RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.29607751
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.25996672
14PPARA_22158963_ChIP-Seq_LIVER_Mouse2.17998751
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.15408909
16FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.08658514
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.07059461
18IRF8_27001747_Chip-Seq_BMDM_Mouse2.04167290
19STAT6_21828071_ChIP-Seq_BEAS2B_Human2.01365717
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.00937130
21* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.96506375
22* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.96506375
23ESR2_21235772_ChIP-Seq_MCF-7_Human1.79836811
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.76969843
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.72377027
26VDR_21846776_ChIP-Seq_THP-1_Human1.68020370
27EGR1_19374776_ChIP-ChIP_THP-1_Human1.67149998
28CDX2_19796622_ChIP-Seq_MESCs_Mouse1.66239302
29NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.62885043
30MYB_21317192_ChIP-Seq_ERMYB_Mouse1.58941658
31* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.57220099
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.56895195
33TFEB_21752829_ChIP-Seq_HELA_Human1.55243950
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.50781671
35KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.46422797
36CLOCK_20551151_ChIP-Seq_293T_Human1.43005606
37DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.42967495
38MYC_22102868_ChIP-Seq_BL_Human1.42920520
39TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42736653
40TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.42147317
41GATA2_21666600_ChIP-Seq_HMVEC_Human1.41639243
42SOX2_20726797_ChIP-Seq_SW620_Human1.40788652
43* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.39832049
44ESR1_21235772_ChIP-Seq_MCF-7_Human1.39262537
45TCF7_22412390_ChIP-Seq_EML_Mouse1.37033928
46VDR_24787735_ChIP-Seq_THP-1_Human1.36719608
47VDR_24763502_ChIP-Seq_THP-1_Human1.36109192
48RXR_22108803_ChIP-Seq_LS180_Human1.35890368
49BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.34590484
50IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.34497384
51STAT4_19710469_ChIP-ChIP_TH1__Mouse1.34293344
52TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.31825418
53TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.31162383
54RUNX1_22412390_ChIP-Seq_EML_Mouse1.30948981
55NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.30247869
56HIF1A_21447827_ChIP-Seq_MCF-7_Human1.29868319
57UBF1/2_26484160_Chip-Seq_HMECs_Human1.29684962
58STAT3_1855785_ChIP-Seq_MESCs_Mouse1.26875290
59TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26453927
60CJUN_26792858_Chip-Seq_BT549_Human1.26246541
61KLF4_18555785_ChIP-Seq_MESCs_Mouse1.26122052
62JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24919030
63SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.24406079
64PPAR_26484153_Chip-Seq_NCI-H1993_Human1.24095239
65ZNF217_24962896_ChIP-Seq_MCF-7_Human1.22646092
66CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.22200752
67JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22179761
68TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20834646
69EGR1_23403033_ChIP-Seq_LIVER_Mouse1.20326844
70FOXO3_23340844_ChIP-Seq_DLD1_Human1.19987025
71GATA1_22025678_ChIP-Seq_K562_Human1.17682796
72NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.17228498
73KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.16814586
74AR_21909140_ChIP-Seq_LNCAP_Human1.14338540
75ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.13154478
76PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12724689
77SMAD_19615063_ChIP-ChIP_OVARY_Human1.12636595
78KDM2B_26808549_Chip-Seq_DND41_Human1.11956196
79UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.11533074
80CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10523090
81BRD4_27068464_Chip-Seq_AML-cells_Mouse1.09399057
82SPI1_23547873_ChIP-Seq_NB4_Human1.08882155
83EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.08507170
84VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06176606
85RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.05711510
86CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05403148
87STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.05245962
88GATA1_22383799_ChIP-Seq_G1ME_Mouse1.04205346
89PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03199901
90SRY_22984422_ChIP-ChIP_TESTIS_Rat1.02735406
91* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02469908
92SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02244141
93ATF3_27146783_Chip-Seq_COLON_Human1.00482786
94NCOR1_26117541_ChIP-Seq_K562_Human0.99627690
95MAF_26560356_Chip-Seq_TH1_Human0.99556956
96P63_26484246_Chip-Seq_KERATINOCYTES_Human0.99097584
97TP53_18474530_ChIP-ChIP_U2OS_Human0.98972669
98* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.98662689
99NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.98516162
100SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.98360448
101PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.98248517
102* TP53_22127205_ChIP-Seq_IMR90_Human0.97745949
103SALL4_18804426_ChIP-ChIP_XEN_Mouse0.97437350
104SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.96318527
105SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.96318527
106KDM2B_26808549_Chip-Seq_K562_Human0.95811574
107CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95411441
108SOX2_27498859_Chip-Seq_STOMACH_Mouse0.95093864
109SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.94922778
110CDX2_20551321_ChIP-Seq_CACO-2_Human0.94628387
111NR3C1_23031785_ChIP-Seq_PC12_Mouse0.94145395
112FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.93391951
113ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.92709297
114EGR1_19032775_ChIP-ChIP_M12_Human0.92648129
115ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.92366975
116GATA2_19941826_ChIP-Seq_K562_Human0.92269278
117P300_27058665_Chip-Seq_ZR-75-30cells_Human0.91450118
118SPI1_23127762_ChIP-Seq_K562_Human0.91197811
119FOXA2_19822575_ChIP-Seq_HepG2_Human0.90458247
120MTF2_20144788_ChIP-Seq_MESCs_Mouse0.89877916
121RACK7_27058665_Chip-Seq_MCF-7_Human0.89804891
122LXR_22292898_ChIP-Seq_THP-1_Human0.88731286
123IKZF1_21737484_ChIP-ChIP_HCT116_Human0.88535096
124RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.87185423
125STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.85359843
126KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.84934354
127TP63_23658742_ChIP-Seq_EP156T_Human0.83567857
128STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.83429901
129GATA1_19941826_ChIP-Seq_K562_Human0.82625799
130TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.82265850
131ESR1_20079471_ChIP-ChIP_T-47D_Human0.80224254
132* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.78896467
133ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.78273562
134ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.77335562
135PU_27001747_Chip-Seq_BMDM_Mouse0.77266274
136TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.77222692
137* ELK3_25401928_ChIP-Seq_HUVEC_Human0.76656457
138SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.75211211
139AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.74271199
140KDM2B_26808549_Chip-Seq_SUP-B15_Human0.73484948
141KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.73468056
142SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.73170303

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition3.33846190
2MP0003303_peritoneal_inflammation3.18564950
3MP0005360_urolithiasis2.95791338
4MP0003436_decreased_susceptibility_to2.84899008
5MP0005058_abnormal_lysosome_morphology2.82852376
6MP0009840_abnormal_foam_cell2.77363243
7MP0002139_abnormal_hepatobiliary_system2.49800883
8MP0003195_calcinosis2.47314560
9MP0004858_abnormal_nervous_system2.40436690
10MP0004510_myositis2.27888721
11MP0003172_abnormal_lysosome_physiology2.14732645
12MP0000604_amyloidosis2.11713444
13MP0008260_abnormal_autophagy2.08274968
14MP0006082_CNS_inflammation2.06995073
15MP0008438_abnormal_cutaneous_collagen1.98746452
16MP0003705_abnormal_hypodermis_morpholog1.90858953
17MP0003075_altered_response_to1.88526627
18MP0003191_abnormal_cellular_cholesterol1.88189793
19MP0003300_gastrointestinal_ulcer1.87856421
20MP0001533_abnormal_skeleton_physiology1.82709935
21MP0009785_altered_susceptibility_to1.80976642
22MP0002735_abnormal_chemical_nociception1.79814218
23MP0009764_decreased_sensitivity_to1.72898178
24MP0002419_abnormal_innate_immunity1.72353606
25MP0003183_abnormal_peptide_metabolism1.71239145
26MP0002254_reproductive_system_inflammat1.68836118
27MP0000343_altered_response_to1.64418552
28MP0004233_abnormal_muscle_weight1.63072764
29MP0008875_abnormal_xenobiotic_pharmacok1.61636643
30MP0005166_decreased_susceptibility_to1.60713943
31MP0010329_abnormal_lipoprotein_level1.60279666
32MP0005085_abnormal_gallbladder_physiolo1.59518482
33MP0009780_abnormal_chondrocyte_physiolo1.57992883
34MP0010352_gastrointestinal_tract_polyps1.57183990
35MP0005083_abnormal_biliary_tract1.52730594
36MP0003690_abnormal_glial_cell1.50793277
37MP0002909_abnormal_adrenal_gland1.50392187
38MP0002998_abnormal_bone_remodeling1.49805093
39MP0005365_abnormal_bile_salt1.49267313
40MP0003950_abnormal_plasma_membrane1.47974472
41MP0002877_abnormal_melanocyte_morpholog1.43160137
42MP0005076_abnormal_cell_differentiation1.42806350
43MP0001835_abnormal_antigen_presentation1.40426303
44MP0003656_abnormal_erythrocyte_physiolo1.40025151
45MP0003828_pulmonary_edema1.39651305
46MP0003566_abnormal_cell_adhesion1.39127490
47MP0002148_abnormal_hypersensitivity_rea1.37765226
48MP0001849_ear_inflammation1.37623660
49MP0001853_heart_inflammation1.33901744
50MP0003252_abnormal_bile_duct1.33138559
51MP0004947_skin_inflammation1.32955457
52MP0003186_abnormal_redox_activity1.32713747
53MP0003329_amyloid_beta_deposits1.32416845
54MP0004859_abnormal_synaptic_plasticity1.32052159
55MP0003091_abnormal_cell_migration1.31237538
56MP0005000_abnormal_immune_tolerance1.30439232
57MP0002138_abnormal_hepatobiliary_system1.26921533
58MP0004270_analgesia1.25829860
59MP0005164_abnormal_response_to1.24644257
60MP0005464_abnormal_platelet_physiology1.24325817
61MP0005257_abnormal_intraocular_pressure1.24270216
62MP0003011_delayed_dark_adaptation1.20694941
63MP0004185_abnormal_adipocyte_glucose1.18385246
64MP0003448_altered_tumor_morphology1.17156144
65MP0005167_abnormal_blood-brain_barrier1.16064395
66MP0000609_abnormal_liver_physiology1.15886979
67MP0001501_abnormal_sleep_pattern1.15053826
68MP0008469_abnormal_protein_level1.14980398
69MP0005025_abnormal_response_to1.14652802
70MP0003453_abnormal_keratinocyte_physiol1.12371780
71MP0003045_fibrosis1.12138847
72MP0002796_impaired_skin_barrier1.11587384
73MP0005319_abnormal_enzyme/_coenzyme1.10481947
74MP0003724_increased_susceptibility_to1.09704340
75MP0009333_abnormal_splenocyte_physiolog1.08127939
76MP0002090_abnormal_vision1.07928450
77MP0002060_abnormal_skin_morphology1.07839840
78MP0006054_spinal_hemorrhage1.07636058
79MP0010386_abnormal_urinary_bladder1.07402057
80MP0001216_abnormal_epidermal_layer1.07091608
81MP0001968_abnormal_touch/_nociception1.06848904
82MP0002118_abnormal_lipid_homeostasis1.06615608
83MP0002933_joint_inflammation1.06089699
84MP0001845_abnormal_inflammatory_respons1.05682782
85MP0005535_abnormal_body_temperature1.05463419
86MP0003941_abnormal_skin_development1.03906717
87MP0002736_abnormal_nociception_after1.01332920
88MP0009046_muscle_twitch0.99550212
89MP0004272_abnormal_basement_membrane0.98866392
90MP0001666_abnormal_nutrient_absorption0.97986297
91MP0004130_abnormal_muscle_cell0.97679249
92MP0005584_abnormal_enzyme/coenzyme_acti0.97095801
93MP0000685_abnormal_immune_system0.96970892
94MP0003879_abnormal_hair_cell0.96252291
95MP0002733_abnormal_thermal_nociception0.95693202
96MP0005332_abnormal_amino_acid0.95278653
97MP0009278_abnormal_bone_marrow0.93666614
98MP0004019_abnormal_vitamin_homeostasis0.93621642
99MP0004043_abnormal_pH_regulation0.93330443
100MP0008004_abnormal_stomach_pH0.92736106
101MP0010234_abnormal_vibrissa_follicle0.92525494
102MP0001915_intracranial_hemorrhage0.91081133
103MP0003806_abnormal_nucleotide_metabolis0.89353555
104MP0005448_abnormal_energy_balance0.87360573
105MP0002896_abnormal_bone_mineralization0.86803416
106MP0008961_abnormal_basal_metabolism0.84767382
107MP0001545_abnormal_hematopoietic_system0.84227757
108MP0005397_hematopoietic_system_phenotyp0.84227757
109MP0003279_aneurysm0.83295245
110MP0010155_abnormal_intestine_physiology0.83032362
111MP0002405_respiratory_system_inflammati0.82717325
112MP0000920_abnormal_myelination0.81451432
113MP0002332_abnormal_exercise_endurance0.81388679
114MP0002723_abnormal_immune_serum0.80653464
115MP0002734_abnormal_mechanical_nocicepti0.79958240
116MP0005390_skeleton_phenotype0.79177818
117MP0003795_abnormal_bone_structure0.79005445
118MP0001440_abnormal_grooming_behavior0.78763452
119MP0005621_abnormal_cell_physiology0.78370846
120MP0005023_abnormal_wound_healing0.77961053
121MP0003221_abnormal_cardiomyocyte_apopto0.77955583
122MP0002452_abnormal_antigen_presenting0.77252476
123MP0001299_abnormal_eye_distance/0.76960391
124MP0009643_abnormal_urine_homeostasis0.76774692
125MP0008873_increased_physiological_sensi0.75984212
126MP0005165_increased_susceptibility_to0.75364166
127MP0004883_abnormal_blood_vessel0.75274147
128MP0010307_abnormal_tumor_latency0.74930026
129MP0005501_abnormal_skin_physiology0.74900971
130MP0004808_abnormal_hematopoietic_stem0.74847206
131MP0000747_muscle_weakness0.74325733
132MP0000858_altered_metastatic_potential0.74149976
133MP0001881_abnormal_mammary_gland0.74074359
134MP0009763_increased_sensitivity_to0.73895453
135MP0005310_abnormal_salivary_gland0.73327895
136MP0009053_abnormal_anal_canal0.73092214
137MP0000371_diluted_coat_color0.72937951
138MP0001790_abnormal_immune_system0.72136644
139MP0005387_immune_system_phenotype0.72136644
140MP0000750_abnormal_muscle_regeneration0.71012409
141MP0005409_darkened_coat_color0.70533295
142MP0001243_abnormal_dermal_layer0.70398692
143MP0001851_eye_inflammation0.70199501

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.44223041
2Recurrent gram-negative bacterial infections (HP:0005420)4.24360540
3Increased cerebral lipofuscin (HP:0011813)4.01821734
4Tetraparesis (HP:0002273)3.87399742
5Abnormality of proline metabolism (HP:0010907)3.69968041
6Hydroxyprolinuria (HP:0003080)3.69968041
7Axonal loss (HP:0003447)3.64272104
8Epiphyseal dysplasia (HP:0002656)3.56563575
9Abnormality of glutamine family amino acid metabolism (HP:0010902)3.48420985
10Cupped ribs (HP:0000887)3.41573175
11Increased neuronal autofluorescent lipopigment (HP:0002074)3.40371247
12Neurofibrillary tangles (HP:0002185)3.30687448
13Abnormal gallbladder physiology (HP:0012438)3.26317836
14Cholecystitis (HP:0001082)3.26317836
15Cerebral inclusion bodies (HP:0100314)3.04887493
16Nuclear cataract (HP:0100018)2.98340445
17Flat acetabular roof (HP:0003180)2.89419004
18Abnormality of macrophages (HP:0004311)2.87974627
19Premature rupture of membranes (HP:0001788)2.86493511
20Xanthomatosis (HP:0000991)2.82763930
21Recurrent abscess formation (HP:0002722)2.78687952
22Myocardial infarction (HP:0001658)2.76694508
23Vacuolated lymphocytes (HP:0001922)2.73132480
24Abnormality of the Achilles tendon (HP:0005109)2.67846307
25Achilles tendon contracture (HP:0001771)2.67211994
26Recurrent bacterial skin infections (HP:0005406)2.66602478
27Protuberant abdomen (HP:0001538)2.65968565
28Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.65221405
29Vertebral compression fractures (HP:0002953)2.65014546
30Dysostosis multiplex (HP:0000943)2.60139561
31Mucopolysacchariduria (HP:0008155)2.59741932
32Urinary glycosaminoglycan excretion (HP:0003541)2.59741932
33Vitreoretinal degeneration (HP:0000655)2.58394747
34Abnormal tarsal ossification (HP:0008369)2.54889214
35Interstitial pulmonary disease (HP:0006530)2.48732262
36Osteolytic defects of the phalanges of the hand (HP:0009771)2.47522713
37Osteolytic defects of the hand bones (HP:0009699)2.47522713
38Short nail (HP:0001799)2.41404368
39Gingivitis (HP:0000230)2.40127727
40Abnormality of glycosaminoglycan metabolism (HP:0004371)2.36615059
41Abnormality of mucopolysaccharide metabolism (HP:0011020)2.36615059
42Abnormality of polysaccharide metabolism (HP:0011012)2.36615059
43Protrusio acetabuli (HP:0003179)2.35959219
44Ovoid vertebral bodies (HP:0003300)2.30913006
45Abnormality of the lumbar spine (HP:0100712)2.29610740
46Autoimmune thrombocytopenia (HP:0001973)2.28518572
47Apathy (HP:0000741)2.27699928
48Upper motor neuron abnormality (HP:0002127)2.27320853
49Metaphyseal cupping (HP:0003021)2.27048685
50Distal lower limb amyotrophy (HP:0008944)2.26996419
51Increased serum ferritin (HP:0003281)2.26741987
52Distal lower limb muscle weakness (HP:0009053)2.26177076
53Sensorimotor neuropathy (HP:0007141)2.25939945
54Distal upper limb amyotrophy (HP:0007149)2.25330159
55Upper limb amyotrophy (HP:0009129)2.25330159
56Thick nail (HP:0001805)2.25203696
57Diminished motivation (HP:0000745)2.25024001
58Systemic lupus erythematosus (HP:0002725)2.22029464
59Abnormality of glycolipid metabolism (HP:0010969)2.19427028
60Abnormality of liposaccharide metabolism (HP:0010968)2.19427028
61Abnormality of glycosphingolipid metabolism (HP:0004343)2.19427028
62Hypoplastic ischia (HP:0003175)2.18404271
63Global brain atrophy (HP:0002283)2.15972180
64Irregular epiphyses (HP:0010582)2.15399983
65Beaking of vertebral bodies (HP:0004568)2.13433913
66Prolonged neonatal jaundice (HP:0006579)2.11782080
67Osteoarthritis (HP:0002758)2.11495855
68Hand muscle atrophy (HP:0009130)2.10504139
69Esophageal varix (HP:0002040)2.10123686
70Deep venous thrombosis (HP:0002625)2.09049612
71Abnormality of the common coagulation pathway (HP:0010990)2.06861646
72Peripheral demyelination (HP:0011096)2.04935380
73Cervical subluxation (HP:0003308)2.04644476
74Coxa vara (HP:0002812)2.03687014
75Increased CSF protein (HP:0002922)2.01845401
76Neuronal loss in central nervous system (HP:0002529)2.01439704
77Abnormality of the ischium (HP:0003174)1.99160631
78Abnormality of the vertebral endplates (HP:0005106)1.98467087
79Asymmetric septal hypertrophy (HP:0001670)1.97219844
80Supranuclear gaze palsy (HP:0000605)1.96002231
81Hyperacusis (HP:0010780)1.95966598
82Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.95539873
83Abnormal gallbladder morphology (HP:0012437)1.94982716
84Increased connective tissue (HP:0009025)1.94851425
85Abnormality of monocarboxylic acid metabolism (HP:0010996)1.94689392
86Thoracolumbar scoliosis (HP:0002944)1.94680685
87Skin nodule (HP:0200036)1.94586328
88Hypercortisolism (HP:0001578)1.91807710
89Abnormality of the distal phalanges of the toes (HP:0010182)1.91747474
90Stomatitis (HP:0010280)1.90915288
91Cholelithiasis (HP:0001081)1.89841856
92Intrahepatic cholestasis (HP:0001406)1.88295349
93Progressive neurologic deterioration (HP:0002344)1.86638009
94Atrophic scars (HP:0001075)1.86560189
95Loss of speech (HP:0002371)1.86017808
96Hypercholesterolemia (HP:0003124)1.85910140
97Thin bony cortex (HP:0002753)1.85842831
98Amyloidosis (HP:0011034)1.84266154
99Hypobetalipoproteinemia (HP:0003563)1.83356124
100Epidermoid cyst (HP:0200040)1.83188670
101Mediastinal lymphadenopathy (HP:0100721)1.81985880
102Abnormality of aromatic amino acid family metabolism (HP:0004338)1.81700844
103Spondylolisthesis (HP:0003302)1.80835884
104Pathologic fracture (HP:0002756)1.80231365
105Nausea (HP:0002018)1.80092221
106Complement deficiency (HP:0004431)1.80044255
107Purpura (HP:0000979)1.78857945
108Bone pain (HP:0002653)1.78523971
109Abdominal distention (HP:0003270)1.78380090
110Recurrent skin infections (HP:0001581)1.77393256
111Fragile skin (HP:0001030)1.77209274
112Mutism (HP:0002300)1.77044807
113Flattened epiphyses (HP:0003071)1.76742335
114Glomerulonephritis (HP:0000099)1.76596329
115Arthropathy (HP:0003040)1.76507173
116Cardiomegaly (HP:0001640)1.74742591
117Abnormality of complement system (HP:0005339)1.74736216
118Hyperparathyroidism (HP:0000843)1.74534810
119Hepatosplenomegaly (HP:0001433)1.73720682
120Reticulocytosis (HP:0001923)1.73398523
121Abnormality of the vasculature of the conjunctiva (HP:0008054)1.72692227
122Natal tooth (HP:0000695)1.70142787
123Broad face (HP:0000283)1.69574125
124Arterial tortuosity (HP:0005116)1.69505374
125Hypolipoproteinemia (HP:0010981)1.69292360
126Disinhibition (HP:0000734)1.69279567
127Joint hemorrhage (HP:0005261)1.68081315
128Cerebral aneurysm (HP:0004944)1.67528944
129Conjugated hyperbilirubinemia (HP:0002908)1.67116764
130Peritonitis (HP:0002586)1.66614610
131Fat malabsorption (HP:0002630)1.66337110
132Difficulty climbing stairs (HP:0003551)1.65871866
133Thoracic kyphosis (HP:0002942)1.65643352
134Small epiphyses (HP:0010585)1.65550904
135Abnormality of iron homeostasis (HP:0011031)1.65519233
136Mitral stenosis (HP:0001718)1.65043260
137Orchitis (HP:0100796)1.64746885
138Recurrent fungal infections (HP:0002841)1.64468901
139Spinal rigidity (HP:0003306)1.64252924
140Cardiovascular calcification (HP:0011915)1.63534198
141Hypoalphalipoproteinemia (HP:0003233)1.63451630
142Vascular calcification (HP:0004934)1.63374157
143Vascular tortuosity (HP:0004948)1.62527100
144Spastic tetraparesis (HP:0001285)1.62511340
145Retinal atrophy (HP:0001105)1.62328466
146Malnutrition (HP:0004395)1.62069739
147Acanthocytosis (HP:0001927)1.62051147
148Turricephaly (HP:0000262)1.61469722
149Ankle contracture (HP:0006466)1.61393637
150Elevated alkaline phosphatase (HP:0003155)1.60929146
151Multiple lipomas (HP:0001012)1.60594724
152Subacute progressive viral hepatitis (HP:0006572)1.58320707
153Abnormality of the thoracic spine (HP:0100711)1.58002752
154Elbow flexion contracture (HP:0002987)1.56935972
155Personality changes (HP:0000751)1.56403411
156Generalized amyotrophy (HP:0003700)1.53145180

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.58716774
2NME23.42244666
3PBK3.40155356
4RIPK42.83813899
5MST1R2.65206599
6TBK12.59834821
7ERBB42.57400248
8EPHB12.56643998
9TAOK22.50735096
10PRPF4B2.48429603
11EPHA32.34079735
12MAP3K32.33342401
13KSR22.30659329
14BMX2.13823789
15PAK42.11948500
16MAP3K92.06918673
17MAP3K22.05166522
18IRAK31.88691646
19MAP3K141.85956374
20SIK11.83987126
21ICK1.77080701
22ABL21.67836977
23DDR21.66628227
24TRIB31.63097381
25MAP3K11.58109671
26FGFR41.54173811
27SMG11.53507935
28JAK11.50152144
29NTRK11.48552024
30RIPK11.41052559
31TGFBR21.40384045
32TAOK31.39118620
33SCYL21.37523058
34EPHA21.37002670
35PIM21.35522372
36NTRK31.35167069
37MAP3K111.32136231
38DAPK21.27097534
39TAOK11.21907127
40GRK71.17446966
41RET1.15443734
42MET1.14652420
43FER1.14556186
44MAP2K11.13585561
45MATK1.12870654
46PRKG21.11002467
47IRAK21.10905161
48CAMKK11.07073731
49NEK91.05027177
50PTK61.04622421
51SIK31.03018292
52CDK121.00732327
53ZAP701.00664067
54CDC42BPA1.00224822
55MAP3K50.94584732
56TYK20.94023856
57MAP3K130.93683217
58MAP3K80.93572143
59PTK20.91731022
60JAK20.90396123
61MAP2K40.89189236
62MUSK0.88236628
63CAMKK20.87401813
64FGFR30.87135269
65PAK60.86968193
66ALK0.86414214
67BMPR20.83935552
68FRK0.83768317
69ARAF0.83418966
70PRKCH0.81593561
71PRKD30.81182941
72EIF2AK10.78976564
73FGR0.78969038
74IKBKB0.76797660
75STK100.75948684
76MOS0.74922869
77MINK10.74502597
78MST40.73240564
79TESK20.72491315
80TESK10.71922973
81PDPK10.71663683
82BLK0.71018719
83IKBKE0.67725429
84MAP3K120.66534646
85PKN20.66264670
86EGFR0.64781243
87IRAK10.64043142
88LATS20.63360663
89CAMK1D0.61875916
90PRKD20.61073429
91DAPK30.60456123
92GRK50.60326805
93CDK60.59449618
94LMTK20.59327761
95TTN0.57400175
96PDGFRA0.57084645
97CSK0.56861087
98MAP2K30.56632310
99BRAF0.56396646
100GSK3A0.53514609
101TRPM70.52022275
102MTOR0.51966409
103MAP2K20.51410639
104PAK30.51299438
105PAK20.50311223
106PRKCD0.49389344
107PDK10.49191672
108EEF2K0.48827546
109PLK20.46779261
110MELK0.46280305
111IRAK40.45045041
112PTK2B0.44096726
113ABL10.41988615
114LIMK10.41064593
115PRKCE0.40751786
116PDK20.40438800
117CDK50.40263880
118STK380.38061059
119KSR10.37716555
120LRRK20.36121504
121SGK30.35388368
122RAF10.34755455
123HCK0.34617203
124CHUK0.34161500
125JAK30.33862651
126CAMK2G0.32537657
127INSR0.32482488
128PDGFRB0.32358245
129PRKACG0.32349699
130RPS6KA20.31969807
131SRC0.31538513
132RPS6KC10.31497370
133RPS6KL10.31497370
134MAP3K60.30634805
135STK240.29433199
136ILK0.27855288
137CLK10.27823306

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.18630200
2Collecting duct acid secretion_Homo sapiens_hsa049661.99799520
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.97638360
4Synaptic vesicle cycle_Homo sapiens_hsa047211.86938869
5Lysosome_Homo sapiens_hsa041421.81103344
6Phagosome_Homo sapiens_hsa041451.79252748
7Arginine biosynthesis_Homo sapiens_hsa002201.78002645
8Leishmaniasis_Homo sapiens_hsa051401.74384393
9Rheumatoid arthritis_Homo sapiens_hsa053231.73195810
10Staphylococcus aureus infection_Homo sapiens_hsa051501.65293276
11Tuberculosis_Homo sapiens_hsa051521.52329077
12Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.51252645
13Legionellosis_Homo sapiens_hsa051341.46798237
14Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.44079324
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.43626237
16Mineral absorption_Homo sapiens_hsa049781.39172212
17Osteoclast differentiation_Homo sapiens_hsa043801.38684126
18Complement and coagulation cascades_Homo sapiens_hsa046101.35484119
19Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.34717060
20Chronic myeloid leukemia_Homo sapiens_hsa052201.33625909
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.32777524
22Malaria_Homo sapiens_hsa051441.29189296
23Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.28508343
24Type I diabetes mellitus_Homo sapiens_hsa049401.26992317
25Vibrio cholerae infection_Homo sapiens_hsa051101.26911447
26Salmonella infection_Homo sapiens_hsa051321.26631970
27Pertussis_Homo sapiens_hsa051331.26561083
28TNF signaling pathway_Homo sapiens_hsa046681.20584962
29Pancreatic cancer_Homo sapiens_hsa052121.16575790
30Bile secretion_Homo sapiens_hsa049761.14841877
31Central carbon metabolism in cancer_Homo sapiens_hsa052301.13973357
32Acute myeloid leukemia_Homo sapiens_hsa052211.12484692
33Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.11905462
34Sphingolipid metabolism_Homo sapiens_hsa006001.11187354
35Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.08647244
36Primary bile acid biosynthesis_Homo sapiens_hsa001201.08453428
37Starch and sucrose metabolism_Homo sapiens_hsa005001.07424860
38PPAR signaling pathway_Homo sapiens_hsa033201.07272279
39Graft-versus-host disease_Homo sapiens_hsa053321.05704727
40Renal cell carcinoma_Homo sapiens_hsa052111.04726354
41NOD-like receptor signaling pathway_Homo sapiens_hsa046211.01708193
42Type II diabetes mellitus_Homo sapiens_hsa049301.00002705
43Pentose and glucuronate interconversions_Homo sapiens_hsa000400.98602684
44Hepatitis B_Homo sapiens_hsa051610.96198435
45Fat digestion and absorption_Homo sapiens_hsa049750.94618237
46Vitamin B6 metabolism_Homo sapiens_hsa007500.92809747
47Adipocytokine signaling pathway_Homo sapiens_hsa049200.92199341
48Amoebiasis_Homo sapiens_hsa051460.91248550
49Dorso-ventral axis formation_Homo sapiens_hsa043200.88394991
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.86708788
51African trypanosomiasis_Homo sapiens_hsa051430.86353464
52Small cell lung cancer_Homo sapiens_hsa052220.86328470
53Glutathione metabolism_Homo sapiens_hsa004800.86226898
54Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.85155792
55Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.84953884
56B cell receptor signaling pathway_Homo sapiens_hsa046620.84034569
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.83172918
58Prion diseases_Homo sapiens_hsa050200.83161475
59Caffeine metabolism_Homo sapiens_hsa002320.82898441
60Steroid biosynthesis_Homo sapiens_hsa001000.82312042
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79877429
62Glycosaminoglycan degradation_Homo sapiens_hsa005310.78290110
63Leukocyte transendothelial migration_Homo sapiens_hsa046700.78080337
64Focal adhesion_Homo sapiens_hsa045100.78025623
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77134529
66Fructose and mannose metabolism_Homo sapiens_hsa000510.75919329
67Thyroid cancer_Homo sapiens_hsa052160.75479630
68Non-small cell lung cancer_Homo sapiens_hsa052230.74902597
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73785519
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.72997376
71Sulfur metabolism_Homo sapiens_hsa009200.72038453
72Measles_Homo sapiens_hsa051620.70823034
73NF-kappa B signaling pathway_Homo sapiens_hsa040640.69285685
74RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.67646751
75Apoptosis_Homo sapiens_hsa042100.64708017
76Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63825622
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63812950
78Toxoplasmosis_Homo sapiens_hsa051450.62946745
79Shigellosis_Homo sapiens_hsa051310.62110747
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.61225534
81Asthma_Homo sapiens_hsa053100.60232497
82Adherens junction_Homo sapiens_hsa045200.59460144
83Insulin resistance_Homo sapiens_hsa049310.58196702
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58019271
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.56678574
86AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56420750
87ErbB signaling pathway_Homo sapiens_hsa040120.55802035
88Hepatitis C_Homo sapiens_hsa051600.55080947
89Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54986706
90Endometrial cancer_Homo sapiens_hsa052130.54897951
91Insulin signaling pathway_Homo sapiens_hsa049100.53107436
92Renin-angiotensin system_Homo sapiens_hsa046140.52448183
93Prolactin signaling pathway_Homo sapiens_hsa049170.52289482
94Chemokine signaling pathway_Homo sapiens_hsa040620.52012503
95Protein digestion and absorption_Homo sapiens_hsa049740.51755375
96Bladder cancer_Homo sapiens_hsa052190.51720762
97Viral carcinogenesis_Homo sapiens_hsa052030.51684450
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51294820
99Allograft rejection_Homo sapiens_hsa053300.50661839
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.50531958
101Prostate cancer_Homo sapiens_hsa052150.50165869
102Pentose phosphate pathway_Homo sapiens_hsa000300.49766895
103Proteoglycans in cancer_Homo sapiens_hsa052050.49457720
104Histidine metabolism_Homo sapiens_hsa003400.49425759
105Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49336336
106Herpes simplex infection_Homo sapiens_hsa051680.49124815
107HIF-1 signaling pathway_Homo sapiens_hsa040660.48635477
108Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48160400
109Tryptophan metabolism_Homo sapiens_hsa003800.47357658
110Vitamin digestion and absorption_Homo sapiens_hsa049770.46922956
111Other glycan degradation_Homo sapiens_hsa005110.46512699
112Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46450643
113Galactose metabolism_Homo sapiens_hsa000520.45815861
114MicroRNAs in cancer_Homo sapiens_hsa052060.45053292
115Influenza A_Homo sapiens_hsa051640.44625867
116Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.44078924
117N-Glycan biosynthesis_Homo sapiens_hsa005100.44035818
118Glioma_Homo sapiens_hsa052140.43365391
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43281888
120Hematopoietic cell lineage_Homo sapiens_hsa046400.42715453
121Selenocompound metabolism_Homo sapiens_hsa004500.41713133
122Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.41628964
123Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41432354
124Notch signaling pathway_Homo sapiens_hsa043300.41126658
125Endocytosis_Homo sapiens_hsa041440.38626773
126Phenylalanine metabolism_Homo sapiens_hsa003600.38417903
127VEGF signaling pathway_Homo sapiens_hsa043700.38407188
128Sphingolipid signaling pathway_Homo sapiens_hsa040710.37879439
129Chemical carcinogenesis_Homo sapiens_hsa052040.37804781
130GABAergic synapse_Homo sapiens_hsa047270.35535346
131mTOR signaling pathway_Homo sapiens_hsa041500.35274882
132GnRH signaling pathway_Homo sapiens_hsa049120.33701486
133Carbon metabolism_Homo sapiens_hsa012000.33574927
134Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33456233
135Insulin secretion_Homo sapiens_hsa049110.33413507

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