SRSF7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.06353502
2DNA strand elongation involved in DNA replication (GO:0006271)5.03879285
3telomere maintenance via semi-conservative replication (GO:0032201)4.92156384
4DNA strand elongation (GO:0022616)4.82170298
5DNA replication initiation (GO:0006270)4.67815039
6telomere maintenance via recombination (GO:0000722)4.43822840
7DNA deamination (GO:0045006)4.35467254
8DNA unwinding involved in DNA replication (GO:0006268)4.30553064
9mitotic recombination (GO:0006312)4.23233391
10maturation of SSU-rRNA (GO:0030490)4.19897141
11nucleobase biosynthetic process (GO:0046112)4.17436393
12DNA replication checkpoint (GO:0000076)4.16125414
13CENP-A containing nucleosome assembly (GO:0034080)4.15849017
14chromatin remodeling at centromere (GO:0031055)4.04063017
15purine nucleobase biosynthetic process (GO:0009113)4.01839361
16telomere maintenance via telomere lengthening (GO:0010833)3.93896177
17nucleotide-excision repair, DNA gap filling (GO:0006297)3.81902375
18DNA replication-independent nucleosome organization (GO:0034724)3.80779850
19DNA replication-independent nucleosome assembly (GO:0006336)3.80779850
20DNA double-strand break processing (GO:0000729)3.80282048
21kinetochore organization (GO:0051383)3.79729256
22formation of translation preinitiation complex (GO:0001731)3.77306966
23viral transcription (GO:0019083)3.74106126
24translational termination (GO:0006415)3.68987606
25deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.67379271
26ribosomal small subunit biogenesis (GO:0042274)3.64333623
27mitotic metaphase plate congression (GO:0007080)3.58920739
28ribosomal large subunit biogenesis (GO:0042273)3.55694693
29kinetochore assembly (GO:0051382)3.54812989
30DNA ligation (GO:0006266)3.53838597
31ribonucleoprotein complex biogenesis (GO:0022613)3.52628582
32ribosome biogenesis (GO:0042254)3.49226748
33regulation of mitotic spindle checkpoint (GO:1903504)3.47360627
34regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.47360627
35proteasome assembly (GO:0043248)3.46523664
36IMP biosynthetic process (GO:0006188)3.46024925
37viral mRNA export from host cell nucleus (GO:0046784)3.43670410
38DNA catabolic process, exonucleolytic (GO:0000738)3.43606291
39spliceosomal snRNP assembly (GO:0000387)3.39720856
40translational elongation (GO:0006414)3.39147849
41SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.39141396
42replication fork processing (GO:0031297)3.37616781
43transcription-coupled nucleotide-excision repair (GO:0006283)3.37051336
44histone exchange (GO:0043486)3.36200529
45pseudouridine synthesis (GO:0001522)3.34228604
46protein localization to kinetochore (GO:0034501)3.33691644
47DNA replication-dependent nucleosome organization (GO:0034723)3.33582166
48DNA replication-dependent nucleosome assembly (GO:0006335)3.33582166
49rRNA processing (GO:0006364)3.33530635
50regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.33462359
51metaphase plate congression (GO:0051310)3.33167972
52establishment of integrated proviral latency (GO:0075713)3.32762328
53chaperone-mediated protein transport (GO:0072321)3.32327959
54cotranslational protein targeting to membrane (GO:0006613)3.31498419
55mitochondrial RNA metabolic process (GO:0000959)3.31358742
56regulation of helicase activity (GO:0051095)3.31352585
57protein targeting to ER (GO:0045047)3.27409612
58translational initiation (GO:0006413)3.27094734
59regulation of nuclear cell cycle DNA replication (GO:0033262)3.24133060
60negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.24077958
61rRNA metabolic process (GO:0016072)3.22590376
62attachment of spindle microtubules to kinetochore (GO:0008608)3.22302188
63transcription from mitochondrial promoter (GO:0006390)3.20619811
64DNA damage response, detection of DNA damage (GO:0042769)3.20019154
65mitotic nuclear envelope disassembly (GO:0007077)3.18497940
66maturation of 5.8S rRNA (GO:0000460)3.17224738
67somatic diversification of immune receptors via somatic mutation (GO:0002566)3.16665829
68somatic hypermutation of immunoglobulin genes (GO:0016446)3.16665829
69spliceosomal complex assembly (GO:0000245)3.16282733
70nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.16252583
71non-recombinational repair (GO:0000726)3.15750419
72double-strand break repair via nonhomologous end joining (GO:0006303)3.15750419
73rRNA modification (GO:0000154)3.15536270
74mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.15455295
75mismatch repair (GO:0006298)3.14258795
76termination of RNA polymerase III transcription (GO:0006386)3.13824540
77transcription elongation from RNA polymerase III promoter (GO:0006385)3.13824540
78exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.13497290
79regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.12836365
80anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.11880578
81ribosome assembly (GO:0042255)3.11484368
82* negative regulation of mRNA processing (GO:0050686)3.11176036
83protein localization to endoplasmic reticulum (GO:0070972)3.08973241
84telomere organization (GO:0032200)3.08754797
85establishment of protein localization to endoplasmic reticulum (GO:0072599)3.08676160
86telomere maintenance (GO:0000723)3.08391064
87signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.07980578
88signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.07980578
89signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.07980578
90G1/S transition of mitotic cell cycle (GO:0000082)3.07046836
91cell cycle G1/S phase transition (GO:0044843)3.07046836
92DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.06600326
93positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.06103621
94mitotic sister chromatid segregation (GO:0000070)3.05281237
95negative regulation of DNA-dependent DNA replication (GO:2000104)3.04272279
96negative regulation of mitotic sister chromatid separation (GO:2000816)3.03929648
97negative regulation of sister chromatid segregation (GO:0033046)3.03929648
98negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.03929648
99negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.03929648
100negative regulation of mitotic sister chromatid segregation (GO:0033048)3.03929648
101intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.03862559
102signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.03862559
103negative regulation of chromosome segregation (GO:0051985)3.03377530
104establishment of protein localization to mitochondrial membrane (GO:0090151)3.02591288
105protein deneddylation (GO:0000338)3.02349477
106* RNA splicing, via transesterification reactions (GO:0000375)3.01875195
107establishment of viral latency (GO:0019043)3.01677898
108* mRNA splicing, via spliceosome (GO:0000398)3.01521444
109* RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.01521444
110nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.01407942
111* negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.00319166
112establishment of chromosome localization (GO:0051303)2.99909404
113maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.99654793
114IMP metabolic process (GO:0046040)2.99617019
115spindle checkpoint (GO:0031577)2.99572722
116mitotic spindle checkpoint (GO:0071174)2.99433399
117signal transduction involved in DNA damage checkpoint (GO:0072422)2.99244250
118signal transduction involved in DNA integrity checkpoint (GO:0072401)2.99244250
119* negative regulation of RNA splicing (GO:0033119)2.98602450
120somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.97647493
121isotype switching (GO:0045190)2.97647493
122somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.97647493
123RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.97418171
124tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.97418171
125histone H2A acetylation (GO:0043968)2.97057903
126meiotic chromosome segregation (GO:0045132)2.96920823
127signal transduction involved in cell cycle checkpoint (GO:0072395)2.96876329
128regulation of cellular amino acid metabolic process (GO:0006521)2.95961735
129positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.95759858
130regulation of double-strand break repair via homologous recombination (GO:0010569)2.95519337
131cellular protein complex disassembly (GO:0043624)2.94777405
1327-methylguanosine mRNA capping (GO:0006370)2.94506695
133protein localization to chromosome, centromeric region (GO:0071459)2.93922640
1347-methylguanosine RNA capping (GO:0009452)2.93808547
135RNA capping (GO:0036260)2.93808547
136intra-S DNA damage checkpoint (GO:0031573)2.93720757
137negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.93705217
138negative regulation of ligase activity (GO:0051352)2.93705217
139respiratory chain complex IV assembly (GO:0008535)2.93473904
140base-excision repair (GO:0006284)2.92721175
141viral life cycle (GO:0019058)2.90762889
142nuclear envelope disassembly (GO:0051081)2.90558880
143membrane disassembly (GO:0030397)2.90558880
144histone mRNA metabolic process (GO:0008334)2.90308400
145deoxyribonucleotide biosynthetic process (GO:0009263)2.89726409
146translation (GO:0006412)2.88870231
147* termination of RNA polymerase II transcription (GO:0006369)2.88732397
148cullin deneddylation (GO:0010388)2.87107001
149* DNA-templated transcription, termination (GO:0006353)2.86848814

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.07740987
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.37318222
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.84208602
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.71950894
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.52348961
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.30601438
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.21787020
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.21629456
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.06595893
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.02997929
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.93247896
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.90983863
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.90734765
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.90428714
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.89077895
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.71261434
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.62457698
18VDR_23849224_ChIP-Seq_CD4+_Human2.51946658
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.49535268
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.48071864
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.42499702
22XRN2_22483619_ChIP-Seq_HELA_Human2.42076850
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.22959297
24FOXP3_21729870_ChIP-Seq_TREG_Human2.22433405
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.18956097
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.12591281
27DCP1A_22483619_ChIP-Seq_HELA_Human2.10236748
28E2F1_18555785_ChIP-Seq_MESCs_Mouse2.07262894
29E2F1_21310950_ChIP-Seq_MCF-7_Human2.06679441
30* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.05618746
31THAP11_20581084_ChIP-Seq_MESCs_Mouse2.00796417
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.00773873
33TTF2_22483619_ChIP-Seq_HELA_Human2.00704986
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.00189677
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.99877852
36MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.98875224
37GABP_19822575_ChIP-Seq_HepG2_Human1.94358679
38ELK1_19687146_ChIP-ChIP_HELA_Human1.91310904
39YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.88357671
40AR_21909140_ChIP-Seq_LNCAP_Human1.87718080
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.84243080
42CIITA_25753668_ChIP-Seq_RAJI_Human1.83239370
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.81665049
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.80966548
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.80803429
46E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.73480687
47SRF_21415370_ChIP-Seq_HL-1_Mouse1.71766032
48KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.68278112
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.66832840
50HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.66704760
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.66107695
52ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.61206272
53ERG_20887958_ChIP-Seq_HPC-7_Mouse1.58128689
54EGR1_19374776_ChIP-ChIP_THP-1_Human1.57998544
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.57964638
56ZFX_18555785_ChIP-Seq_MESCs_Mouse1.54513880
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.52284423
58RBPJ_22232070_ChIP-Seq_NCS_Mouse1.49262923
59TP63_19390658_ChIP-ChIP_HaCaT_Human1.45160914
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.45062632
61PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.42587532
62NANOG_18555785_ChIP-Seq_MESCs_Mouse1.42395327
63CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.39129200
64ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.38868881
65KDM5A_27292631_Chip-Seq_BREAST_Human1.36883979
66PADI4_21655091_ChIP-ChIP_MCF-7_Human1.32138396
67CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31129215
68MYC_22102868_ChIP-Seq_BL_Human1.30937161
69SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.30935047
70ZNF274_21170338_ChIP-Seq_K562_Hela1.29934078
71GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.19915802
72EWS_26573619_Chip-Seq_HEK293_Human1.18943505
73MYC_18940864_ChIP-ChIP_HL60_Human1.16416317
74POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15643872
75E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15105962
76IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.07231188
77* SPI1_23547873_ChIP-Seq_NB4_Human1.07033964
78SOX2_18555785_ChIP-Seq_MESCs_Mouse1.06134662
79DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.05219675
80ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02866792
81POU5F1_16153702_ChIP-ChIP_HESCs_Human1.01466928
82TFEB_21752829_ChIP-Seq_HELA_Human1.01259347
83KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00286082
84CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99434604
85NANOG_16153702_ChIP-ChIP_HESCs_Human0.98292475
86SOX2_16153702_ChIP-ChIP_HESCs_Human0.97901369
87CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.95559211
88VDR_22108803_ChIP-Seq_LS180_Human0.95251914
89* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93709572
90CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.93151597
91ELK1_22589737_ChIP-Seq_MCF10A_Human0.89252740
92FUS_26573619_Chip-Seq_HEK293_Human0.88608725
93KLF4_18555785_ChIP-Seq_MESCs_Mouse0.87392291
94CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87163584
95CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.85352221
96CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.85295159
97IGF1R_20145208_ChIP-Seq_DFB_Human0.84758066
98FLI1_27457419_Chip-Seq_LIVER_Mouse0.82936118
99DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.80842480
100IRF1_19129219_ChIP-ChIP_H3396_Human0.80553639
101VDR_21846776_ChIP-Seq_THP-1_Human0.78818819
102FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77223368
103CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.76698001
104HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.74502304
105STAT3_1855785_ChIP-Seq_MESCs_Mouse0.70657250
106MYB_26560356_Chip-Seq_TH2_Human0.69816669
107MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.69682342
108SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.66934337
109SALL1_21062744_ChIP-ChIP_HESCs_Human0.65894973
110PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.65728609
111SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.65496988
112STAT4_19710469_ChIP-ChIP_TH1__Mouse0.62073223
113* TP53_22573176_ChIP-Seq_HFKS_Human0.61495898
114HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.61428566
115FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.60050402

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.19902163
2MP0010094_abnormal_chromosome_stability4.94383147
3MP0008057_abnormal_DNA_replication4.40612186
4MP0003111_abnormal_nucleus_morphology4.05737271
5MP0004957_abnormal_blastocyst_morpholog4.01642773
6MP0008058_abnormal_DNA_repair3.99979539
7MP0003077_abnormal_cell_cycle3.86457420
8MP0008007_abnormal_cellular_replicative3.25914792
9MP0002396_abnormal_hematopoietic_system3.18397467
10MP0008877_abnormal_DNA_methylation2.59741430
11MP0003123_paternal_imprinting2.51288271
12MP0008932_abnormal_embryonic_tissue2.48223332
13MP0003786_premature_aging2.13872482
14MP0006292_abnormal_olfactory_placode2.02372885
15MP0000350_abnormal_cell_proliferation1.93914151
16MP0003806_abnormal_nucleotide_metabolis1.91032641
17MP0004808_abnormal_hematopoietic_stem1.84971741
18MP0008995_early_reproductive_senescence1.82308866
19MP0000490_abnormal_crypts_of1.82188554
20MP0003763_abnormal_thymus_physiology1.81947735
21MP0006072_abnormal_retinal_apoptosis1.78205465
22MP0001730_embryonic_growth_arrest1.72216255
23MP0003121_genomic_imprinting1.68007116
24MP0009333_abnormal_splenocyte_physiolog1.55252809
25MP0009379_abnormal_foot_pigmentation1.47686040
26MP0000313_abnormal_cell_death1.45992561
27MP0002398_abnormal_bone_marrow1.40906397
28MP0002019_abnormal_tumor_incidence1.38048515
29MP0001697_abnormal_embryo_size1.34963534
30MP0000703_abnormal_thymus_morphology1.31662358
31MP0002210_abnormal_sex_determination1.30868108
32MP0005397_hematopoietic_system_phenotyp1.30139728
33MP0001545_abnormal_hematopoietic_system1.30139728
34MP0000372_irregular_coat_pigmentation1.29621868
35MP0002009_preneoplasia1.28475166
36MP0002080_prenatal_lethality1.26898740
37MP0006054_spinal_hemorrhage1.26656745
38MP0003315_abnormal_perineum_morphology1.25686668
39MP0001672_abnormal_embryogenesis/_devel1.24586868
40MP0005380_embryogenesis_phenotype1.24586868
41MP0002095_abnormal_skin_pigmentation1.22188917
42MP0003567_abnormal_fetal_cardiomyocyte1.19984856
43MP0002938_white_spotting1.19045868
44MP0002722_abnormal_immune_system1.18412890
45MP0001764_abnormal_homeostasis1.17626654
46MP0004147_increased_porphyrin_level1.17540273
47MP0000689_abnormal_spleen_morphology1.17360161
48MP0003718_maternal_effect1.17192710
49MP0005671_abnormal_response_to1.16898461
50MP0005174_abnormal_tail_pigmentation1.14369991
51MP0001188_hyperpigmentation1.13426043
52MP0001529_abnormal_vocalization1.11797444
53MP0003984_embryonic_growth_retardation1.11499143
54MP0001145_abnormal_male_reproductive1.11186192
55MP0001293_anophthalmia1.10996702
56MP0010307_abnormal_tumor_latency1.10056576
57MP0002085_abnormal_embryonic_tissue1.09283440
58MP0002132_abnormal_respiratory_system1.07274103
59MP0002088_abnormal_embryonic_growth/wei1.07152018
60MP0005075_abnormal_melanosome_morpholog1.07132318
61MP0002429_abnormal_blood_cell1.06366334
62MP0001835_abnormal_antigen_presentation1.03107432
63MP0002160_abnormal_reproductive_system1.01051708
64MP0000716_abnormal_immune_system0.97611741
65MP0000653_abnormal_sex_gland0.96450486
66MP0001929_abnormal_gametogenesis0.96071024
67MP0002736_abnormal_nociception_after0.95114311
68MP0005253_abnormal_eye_physiology0.95094698
69MP0010352_gastrointestinal_tract_polyps0.94993469
70MP0002084_abnormal_developmental_patter0.93866539
71MP0004197_abnormal_fetal_growth/weight/0.92142595
72MP0001873_stomach_inflammation0.91836864
73MP0001853_heart_inflammation0.91297467
74MP0005645_abnormal_hypothalamus_physiol0.90521732
75MP0003941_abnormal_skin_development0.90454409
76MP0003890_abnormal_embryonic-extraembry0.90173676
77MP0005499_abnormal_olfactory_system0.89967586
78MP0005394_taste/olfaction_phenotype0.89967586
79MP0001119_abnormal_female_reproductive0.89772933
80MP0002086_abnormal_extraembryonic_tissu0.89458928
81MP0003787_abnormal_imprinting0.89355642
82MP0003943_abnormal_hepatobiliary_system0.88173928
83MP0000015_abnormal_ear_pigmentation0.86200263
84MP0002277_abnormal_respiratory_mucosa0.86138442
85MP0009697_abnormal_copulation0.85435524
86MP0002420_abnormal_adaptive_immunity0.85090075
87MP0000537_abnormal_urethra_morphology0.85012536
88MP0003698_abnormal_male_reproductive0.84256929
89MP0002163_abnormal_gland_morphology0.83980493
90MP0001819_abnormal_immune_cell0.82731921
91MP0001800_abnormal_humoral_immune0.81958826
92MP0000049_abnormal_middle_ear0.80703573
93MP0001919_abnormal_reproductive_system0.80554472
94MP0000465_gastrointestinal_hemorrhage0.80481229
95MP0005389_reproductive_system_phenotype0.78764342
96MP0003937_abnormal_limbs/digits/tail_de0.77824469
97MP0008789_abnormal_olfactory_epithelium0.76928229
98MP0010030_abnormal_orbit_morphology0.75138641
99MP0000647_abnormal_sebaceous_gland0.74157780
100MP0002166_altered_tumor_susceptibility0.73565536
101MP0002254_reproductive_system_inflammat0.73380494
102MP0002452_abnormal_antigen_presenting0.73143220
103MP0002102_abnormal_ear_morphology0.72992206
104MP0001986_abnormal_taste_sensitivity0.71613575
105MP0008872_abnormal_physiological_respon0.71315124
106MP0000858_altered_metastatic_potential0.70638748
107MP0009703_decreased_birth_body0.69681717
108MP0002723_abnormal_immune_serum0.67642527
109MP0000358_abnormal_cell_content/0.67416552
110MP0001346_abnormal_lacrimal_gland0.67086101
111MP0006036_abnormal_mitochondrial_physio0.66332993
112MP0009785_altered_susceptibility_to0.65488282
113MP0004133_heterotaxia0.63974587
114MP0003186_abnormal_redox_activity0.63872184
115MP0002006_tumorigenesis0.62892650
116MP0003122_maternal_imprinting0.62887499
117MP0000516_abnormal_urinary_system0.62703995
118MP0005367_renal/urinary_system_phenotyp0.62703995
119MP0005379_endocrine/exocrine_gland_phen0.62437631
120MP0002405_respiratory_system_inflammati0.62426527
121MP0009672_abnormal_birth_weight0.62053717
122MP0002751_abnormal_autonomic_nervous0.60836737
123MP0002111_abnormal_tail_morphology0.60219955
124MP0001286_abnormal_eye_development0.59998773
125MP0005384_cellular_phenotype0.59939721
126MP0000566_synostosis0.59365475
127MP0006035_abnormal_mitochondrial_morpho0.59053334

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.20397723
2Abnormality of cells of the erythroid lineage (HP:0012130)4.44274201
3Reticulocytopenia (HP:0001896)4.43398575
4Abnormal number of erythroid precursors (HP:0012131)4.43224949
5Aplastic anemia (HP:0001915)4.01964570
6Chromsome breakage (HP:0040012)3.61145430
7Acute necrotizing encephalopathy (HP:0006965)3.40469975
8Colon cancer (HP:0003003)3.40219461
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.34849127
10Breast hypoplasia (HP:0003187)3.33065877
11Oral leukoplakia (HP:0002745)3.29259323
12Abnormality of the preputium (HP:0100587)3.15167910
13Abnormal mitochondria in muscle tissue (HP:0008316)3.13948807
14Acute encephalopathy (HP:0006846)3.10849718
15Patellar aplasia (HP:0006443)3.08864501
16Meckel diverticulum (HP:0002245)3.01582163
1711 pairs of ribs (HP:0000878)3.01029674
18Type I transferrin isoform profile (HP:0003642)2.99388110
19Abnormality of chromosome stability (HP:0003220)2.97420576
20Aplasia/Hypoplasia of the patella (HP:0006498)2.94376337
21Severe combined immunodeficiency (HP:0004430)2.90023831
22Abnormality of the ileum (HP:0001549)2.89908110
23Medulloblastoma (HP:0002885)2.84296033
24Pallor (HP:0000980)2.83322546
25Myelodysplasia (HP:0002863)2.81518076
26Combined immunodeficiency (HP:0005387)2.77422891
27Progressive macrocephaly (HP:0004481)2.72514958
28Aplasia/Hypoplasia of the uvula (HP:0010293)2.67568832
29Macrocytic anemia (HP:0001972)2.66653523
30Rough bone trabeculation (HP:0100670)2.65213462
31Thrombocytosis (HP:0001894)2.64922836
32Lipid accumulation in hepatocytes (HP:0006561)2.63545755
33Agnosia (HP:0010524)2.63113734
34Abnormality of the anterior horn cell (HP:0006802)2.59070493
35Degeneration of anterior horn cells (HP:0002398)2.59070493
36Selective tooth agenesis (HP:0001592)2.58501991
37IgG deficiency (HP:0004315)2.56662231
38Cerebral edema (HP:0002181)2.53705072
39Premature graying of hair (HP:0002216)2.52940365
40Abnormal lung lobation (HP:0002101)2.52624995
41Bone marrow hypocellularity (HP:0005528)2.50576009
42Absent thumb (HP:0009777)2.48712890
43Small intestinal stenosis (HP:0012848)2.46110316
44Duodenal stenosis (HP:0100867)2.46110316
45Abnormality of the heme biosynthetic pathway (HP:0010472)2.40003345
46Microretrognathia (HP:0000308)2.35000909
47Carpal bone hypoplasia (HP:0001498)2.34765534
48Hepatic necrosis (HP:0002605)2.32951228
49IgM deficiency (HP:0002850)2.29482288
50Pancytopenia (HP:0001876)2.25475509
51Sloping forehead (HP:0000340)2.23508416
52Methylmalonic acidemia (HP:0002912)2.22624594
53Cerebral hypomyelination (HP:0006808)2.21500784
54Abnormality of methionine metabolism (HP:0010901)2.20550192
55Lactic acidosis (HP:0003128)2.19790476
56Lymphoma (HP:0002665)2.16640132
57Optic nerve coloboma (HP:0000588)2.15814474
58Neoplasm of the pancreas (HP:0002894)2.15290106
59Type 2 muscle fiber atrophy (HP:0003554)2.14664429
60Panhypogammaglobulinemia (HP:0003139)2.14551184
61Aplasia/Hypoplasia of the sacrum (HP:0008517)2.13810594
62Abnormality of DNA repair (HP:0003254)2.13648124
63Supernumerary spleens (HP:0009799)2.11065575
64Nephroblastoma (Wilms tumor) (HP:0002667)2.10126781
65Abnormal number of incisors (HP:0011064)2.09575632
66Muscle fiber atrophy (HP:0100295)2.08987978
67Cellular immunodeficiency (HP:0005374)2.08601022
68Methylmalonic aciduria (HP:0012120)2.08028176
69Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.07550290
70Abnormal protein N-linked glycosylation (HP:0012347)2.07550290
71Abnormal protein glycosylation (HP:0012346)2.07550290
72Abnormal glycosylation (HP:0012345)2.07550290
73Irregular epiphyses (HP:0010582)2.07221028
74Multiple enchondromatosis (HP:0005701)2.06808877
75Microvesicular hepatic steatosis (HP:0001414)2.06385400
76Abnormality of the duodenum (HP:0002246)2.04415756
77Increased serum lactate (HP:0002151)2.04408787
78Increased intramyocellular lipid droplets (HP:0012240)2.03870462
79Hepatocellular necrosis (HP:0001404)2.01222105
80Triphalangeal thumb (HP:0001199)2.00679502
81Embryonal renal neoplasm (HP:0011794)1.99999089
82Decreased activity of mitochondrial respiratory chain (HP:0008972)1.98845850
83Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.98845850
84Hyperglycinemia (HP:0002154)1.97802978
85Ectopic kidney (HP:0000086)1.97625332
86Amaurosis fugax (HP:0100576)1.97084479
87Atresia of the external auditory canal (HP:0000413)1.96729063
88Reduced antithrombin III activity (HP:0001976)1.94745553
89Duplicated collecting system (HP:0000081)1.94086234
90Abnormality of the labia minora (HP:0012880)1.93363683
91Abnormality of the pons (HP:0007361)1.92788441
92Abnormal trabecular bone morphology (HP:0100671)1.92616298
933-Methylglutaconic aciduria (HP:0003535)1.92388855
94Tracheoesophageal fistula (HP:0002575)1.92167211
95Abnormality of aspartate family amino acid metabolism (HP:0010899)1.91847610
96Asplenia (HP:0001746)1.90853674
97Acute lymphatic leukemia (HP:0006721)1.90031223
98Horseshoe kidney (HP:0000085)1.88849284
99Slender long bone (HP:0003100)1.88519646
100Clubbing of toes (HP:0100760)1.88420363
101Cleft eyelid (HP:0000625)1.88380676
102Renal Fanconi syndrome (HP:0001994)1.87192987
103Abnormal spermatogenesis (HP:0008669)1.86899004
104Hypoplasia of the pons (HP:0012110)1.86503663
105Abnormality of serum amino acid levels (HP:0003112)1.85452062
106Volvulus (HP:0002580)1.84221801
107Abnormality of the renal collecting system (HP:0004742)1.83508250
108Hypoplasia of the capital femoral epiphysis (HP:0003090)1.83352858
109Optic disc pallor (HP:0000543)1.83168879
110Absent radius (HP:0003974)1.82908692
111Mitochondrial inheritance (HP:0001427)1.82446241
112Abnormality of the carotid arteries (HP:0005344)1.82351323
113Ependymoma (HP:0002888)1.82296660
114Exercise intolerance (HP:0003546)1.82173409
115True hermaphroditism (HP:0010459)1.81899648
116Increased CSF lactate (HP:0002490)1.81667427
117Increased hepatocellular lipid droplets (HP:0006565)1.80789732
118Renal cortical cysts (HP:0000803)1.80368654
119Leukodystrophy (HP:0002415)1.80093170
120Pancreatic cysts (HP:0001737)1.79082364
121Prostate neoplasm (HP:0100787)1.78878748
122Pancreatic fibrosis (HP:0100732)1.78721914
123Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.77678816
124Pancreatic islet-cell hyperplasia (HP:0004510)1.77639045
125Neoplasm of the colon (HP:0100273)1.77599180
126Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.77544470
127Aplasia/Hypoplasia of the sternum (HP:0006714)1.76716742
128Abnormality of alanine metabolism (HP:0010916)1.76387470
129Hyperalaninemia (HP:0003348)1.76387470
130Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.76387470
131B lymphocytopenia (HP:0010976)1.75334587
132Abnormality of B cell number (HP:0010975)1.75334587
133Absent forearm bone (HP:0003953)1.75014688
134Aplasia involving forearm bones (HP:0009822)1.75014688
135Short middle phalanx of the 5th finger (HP:0004220)1.74786725
136Glossoptosis (HP:0000162)1.74567572
137Megaloblastic anemia (HP:0001889)1.74489602
138Respiratory difficulties (HP:0002880)1.71462287
139Respiratory failure (HP:0002878)1.70439601
140Lethargy (HP:0001254)1.69971691

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.20256471
2BUB14.15193264
3CDC73.80565032
4STK163.59758419
5VRK23.25277237
6EIF2AK13.20537436
7SRPK12.78927243
8TSSK62.72734747
9VRK12.71050952
10NUAK12.60029745
11MKNK12.48673471
12BRSK22.40842791
13ACVR1B2.35570973
14EIF2AK32.35450331
15CCNB12.12390529
16NEK22.06221322
17DYRK32.04496404
18TRIM282.04145518
19PASK2.00103506
20PLK41.97775502
21NME21.95270579
22MKNK21.92096842
23ATR1.80841206
24PLK11.72640585
25PLK31.63630602
26CDK71.60409348
27CDK81.55796403
28PDK21.55587086
29BRSK11.50570942
30AURKB1.50312451
31TAF11.49494726
32TTK1.49117984
33MAP4K21.47995158
34TGFBR11.47245348
35TLK11.43952268
36NEK11.38142922
37RPS6KA41.31097754
38PIM21.28746860
39CHEK21.22235223
40WNK31.22032374
41RPS6KB21.16859501
42BCKDK1.14923484
43TESK21.12813804
44TEC1.06947319
45EIF2AK21.02600669
46CHEK11.01370606
47CDK41.01187186
48ZAK0.98354705
49AURKA0.95382630
50CSNK1G10.91920892
51MAP4K10.91773767
52KIT0.88774570
53YES10.88352607
54FLT30.87842384
55CLK10.86724676
56BRD40.85218812
57BTK0.84563935
58BCR0.80858726
59IRAK40.78498250
60ATM0.77744816
61SCYL20.77368830
62TNIK0.77076476
63CSNK2A10.74429768
64TXK0.73841112
65NME10.73462794
66PAK40.72784296
67PIM10.71291030
68CSNK2A20.71115897
69CDK20.70867232
70TAOK30.70562547
71ERBB30.69338917
72STK40.69016621
73MST40.68462494
74MAP3K80.65292414
75GRK10.62535547
76DAPK10.61771799
77KDR0.61010832
78DYRK20.57416404
79CSNK1G20.56804942
80CSNK1A1L0.56790692
81CDK10.55929730
82MAP2K30.54757551
83CDK190.52025214
84STK100.51107176
85TAOK20.50063976
86ALK0.49102496
87RPS6KA50.46567732
88TIE10.45361270
89BMPR1B0.44346910
90ZAP700.42948260
91CSF1R0.42474489
92BRAF0.40986118
93LYN0.40198806
94PRKCI0.39903381
95MAP3K120.37328296
96PBK0.36630396
97PAK10.36267687
98INSRR0.35572957
99OXSR10.35413792
100RPS6KA60.35123134
101CSNK1E0.33812678
102CDK30.33762753
103ITK0.32845875
104EEF2K0.31409303
105NLK0.31303716
106RPS6KL10.30254315
107RPS6KC10.30254315
108SYK0.30100001
109CSNK1G30.29668665
110IRAK30.29556573
111MAP3K40.28319535
112MAP3K100.28259141
113PRKDC0.27493969
114RPS6KB10.27244688
115PLK20.26056227
116CDK60.24684521
117CSNK1A10.24452058
118PNCK0.23015700
119ADRBK20.22200926
120IKBKB0.21316269
121JAK30.21000797
122CDK90.20983764
123SIK30.20383845
124MAPK130.20370654
125MAP2K70.19013942
126MAPK140.18547485

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.15182528
2Mismatch repair_Homo sapiens_hsa034304.37045639
3Ribosome_Homo sapiens_hsa030103.61245200
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.44194918
5Proteasome_Homo sapiens_hsa030503.40873806
6* Spliceosome_Homo sapiens_hsa030403.40356332
7RNA polymerase_Homo sapiens_hsa030203.38058720
8Base excision repair_Homo sapiens_hsa034103.28131147
9Homologous recombination_Homo sapiens_hsa034403.18028808
10Nucleotide excision repair_Homo sapiens_hsa034203.00011185
11RNA transport_Homo sapiens_hsa030132.79125273
12Pyrimidine metabolism_Homo sapiens_hsa002402.62547026
13Cell cycle_Homo sapiens_hsa041102.54400891
14Non-homologous end-joining_Homo sapiens_hsa034502.50209939
15Fanconi anemia pathway_Homo sapiens_hsa034602.33117289
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.13035221
17Basal transcription factors_Homo sapiens_hsa030222.06378534
18One carbon pool by folate_Homo sapiens_hsa006702.05726263
19RNA degradation_Homo sapiens_hsa030182.04357517
20Protein export_Homo sapiens_hsa030601.69960104
21mRNA surveillance pathway_Homo sapiens_hsa030151.62930762
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.55809718
23Purine metabolism_Homo sapiens_hsa002301.51482721
24p53 signaling pathway_Homo sapiens_hsa041151.38087861
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.26511353
26Epstein-Barr virus infection_Homo sapiens_hsa051691.20393229
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.15476278
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13217073
29Propanoate metabolism_Homo sapiens_hsa006401.10834674
30* Herpes simplex infection_Homo sapiens_hsa051681.02648960
31Antigen processing and presentation_Homo sapiens_hsa046120.99516145
32Systemic lupus erythematosus_Homo sapiens_hsa053220.95451317
33Primary immunodeficiency_Homo sapiens_hsa053400.95400048
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93072023
35Fatty acid elongation_Homo sapiens_hsa000620.89935977
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.88332398
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.85760475
38Pyruvate metabolism_Homo sapiens_hsa006200.85745655
39N-Glycan biosynthesis_Homo sapiens_hsa005100.76271277
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74936979
41Viral carcinogenesis_Homo sapiens_hsa052030.73705752
42Oocyte meiosis_Homo sapiens_hsa041140.73601773
43Huntingtons disease_Homo sapiens_hsa050160.73601659
44Parkinsons disease_Homo sapiens_hsa050120.72465260
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.71155112
46Legionellosis_Homo sapiens_hsa051340.71092102
47Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69339317
48Steroid biosynthesis_Homo sapiens_hsa001000.67637308
49Carbon metabolism_Homo sapiens_hsa012000.66227465
50HTLV-I infection_Homo sapiens_hsa051660.65633722
51Folate biosynthesis_Homo sapiens_hsa007900.65275711
52Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61582012
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60878175
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60143837
55Thyroid cancer_Homo sapiens_hsa052160.58274162
56Measles_Homo sapiens_hsa051620.54166427
57Cysteine and methionine metabolism_Homo sapiens_hsa002700.52424654
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50335672
59Oxidative phosphorylation_Homo sapiens_hsa001900.49546109
60Allograft rejection_Homo sapiens_hsa053300.48721576
61Drug metabolism - other enzymes_Homo sapiens_hsa009830.47446008
62Cyanoamino acid metabolism_Homo sapiens_hsa004600.47283236
63RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.47281970
64Alcoholism_Homo sapiens_hsa050340.46697681
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46507462
66Pentose phosphate pathway_Homo sapiens_hsa000300.45133588
67Hematopoietic cell lineage_Homo sapiens_hsa046400.45073555
68Intestinal immune network for IgA production_Homo sapiens_hsa046720.44249849
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43927122
70NF-kappa B signaling pathway_Homo sapiens_hsa040640.43704299
71Peroxisome_Homo sapiens_hsa041460.43562409
72Phototransduction_Homo sapiens_hsa047440.43388394
73Hepatitis B_Homo sapiens_hsa051610.41295609
74Selenocompound metabolism_Homo sapiens_hsa004500.40413928
75Caffeine metabolism_Homo sapiens_hsa002320.36951520
76Type I diabetes mellitus_Homo sapiens_hsa049400.36586979
77Butanoate metabolism_Homo sapiens_hsa006500.36153413
78Sulfur relay system_Homo sapiens_hsa041220.34610723
79Small cell lung cancer_Homo sapiens_hsa052220.34343358
80Vitamin digestion and absorption_Homo sapiens_hsa049770.34298234
81Apoptosis_Homo sapiens_hsa042100.33667207
82Influenza A_Homo sapiens_hsa051640.33470701
83Asthma_Homo sapiens_hsa053100.32510784
84Shigellosis_Homo sapiens_hsa051310.32248080
85Colorectal cancer_Homo sapiens_hsa052100.31630945
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30873369
87NOD-like receptor signaling pathway_Homo sapiens_hsa046210.30819550
88Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.29599071
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29538234
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29004009
91MicroRNAs in cancer_Homo sapiens_hsa052060.28865355
92Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.27033296
93Biosynthesis of amino acids_Homo sapiens_hsa012300.26231904
94Nitrogen metabolism_Homo sapiens_hsa009100.25922749
95Glutathione metabolism_Homo sapiens_hsa004800.25907142
96Graft-versus-host disease_Homo sapiens_hsa053320.24779409
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.24778697
98Fatty acid metabolism_Homo sapiens_hsa012120.22899737
99Autoimmune thyroid disease_Homo sapiens_hsa053200.22367782
100Vitamin B6 metabolism_Homo sapiens_hsa007500.21870613
101Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21639360
102Tryptophan metabolism_Homo sapiens_hsa003800.21371720
103Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.20777176
104TGF-beta signaling pathway_Homo sapiens_hsa043500.20567038
105Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.20116792
106Metabolic pathways_Homo sapiens_hsa011000.19562459
107Sulfur metabolism_Homo sapiens_hsa009200.19521007
108Pentose and glucuronate interconversions_Homo sapiens_hsa000400.19139502
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.18366827
110Regulation of autophagy_Homo sapiens_hsa041400.18290552
111Arachidonic acid metabolism_Homo sapiens_hsa005900.17933989
112Lysine degradation_Homo sapiens_hsa003100.17795689
113Cardiac muscle contraction_Homo sapiens_hsa042600.17246386
114Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.16909254
115Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.16700630
116Alzheimers disease_Homo sapiens_hsa050100.16368440
117Leishmaniasis_Homo sapiens_hsa051400.15039662
118Pathways in cancer_Homo sapiens_hsa052000.14612388
119Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.14545317
120Basal cell carcinoma_Homo sapiens_hsa052170.13876777
121Jak-STAT signaling pathway_Homo sapiens_hsa046300.12809304
122Renin-angiotensin system_Homo sapiens_hsa046140.11822256
123Notch signaling pathway_Homo sapiens_hsa043300.11779638
124Viral myocarditis_Homo sapiens_hsa054160.11459157
125Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.09658067
126Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.09368774
127Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.09349626
128T cell receptor signaling pathway_Homo sapiens_hsa046600.08866771

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