SRRD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)9.56234349
2DNA deamination (GO:0045006)7.97087289
3transcription from mitochondrial promoter (GO:0006390)7.52423193
4replication fork processing (GO:0031297)7.14387931
5proline metabolic process (GO:0006560)7.07828443
6embryonic process involved in female pregnancy (GO:0060136)6.68414625
7positive regulation of protein homooligomerization (GO:0032464)6.41473370
8maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)6.16625789
9oxidative demethylation (GO:0070989)5.86111294
10establishment of apical/basal cell polarity (GO:0035089)5.44257601
11regulation of integrin activation (GO:0033623)5.21962392
12mitochondrial DNA metabolic process (GO:0032042)5.18854469
13viral mRNA export from host cell nucleus (GO:0046784)5.13230867
14regulation of protein homooligomerization (GO:0032462)5.09541595
15poly(A)+ mRNA export from nucleus (GO:0016973)5.02598304
16establishment or maintenance of monopolar cell polarity (GO:0061339)5.01688998
17establishment of monopolar cell polarity (GO:0061162)5.01688998
18mitotic sister chromatid cohesion (GO:0007064)4.92105785
19DNA strand renaturation (GO:0000733)4.78505942
20telomere maintenance via semi-conservative replication (GO:0032201)4.71287165
21negative regulation of JAK-STAT cascade (GO:0046426)4.71044215
22formation of translation preinitiation complex (GO:0001731)4.67574526
23somatic diversification of immune receptors via somatic mutation (GO:0002566)4.67257568
24somatic hypermutation of immunoglobulin genes (GO:0016446)4.67257568
25establishment of protein localization to mitochondrial membrane (GO:0090151)4.48792739
26mitotic G1 DNA damage checkpoint (GO:0031571)4.45029525
27negative regulation of cell cycle arrest (GO:0071157)4.36913957
28base-excision repair (GO:0006284)4.35586197
29GDP-mannose metabolic process (GO:0019673)4.30278146
30protoporphyrinogen IX metabolic process (GO:0046501)4.24183485
31negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.21141846
32pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.18429485
33cellular response to ATP (GO:0071318)4.18182474
34nucleotide-excision repair, DNA gap filling (GO:0006297)4.15327791
35base-excision repair, AP site formation (GO:0006285)4.12715473
36histone H4-K12 acetylation (GO:0043983)4.11562729
37regulation of translational termination (GO:0006449)4.07473546
38mRNA cleavage (GO:0006379)4.05134089
39positive regulation of developmental pigmentation (GO:0048087)3.99362644
40G1 DNA damage checkpoint (GO:0044783)3.96623169
41nuclear pore complex assembly (GO:0051292)3.93425915
42DNA strand elongation involved in DNA replication (GO:0006271)3.88334333
43mitotic G1/S transition checkpoint (GO:0044819)3.87778992
44termination of RNA polymerase II transcription (GO:0006369)3.86879639
45DNA integration (GO:0015074)3.84504737
46nuclear envelope reassembly (GO:0031468)3.83935657
47mitotic nuclear envelope reassembly (GO:0007084)3.83935657
48DNA double-strand break processing (GO:0000729)3.79285058
49telomere maintenance via recombination (GO:0000722)3.79198374
50embryonic placenta development (GO:0001892)3.76347571
51kinetochore organization (GO:0051383)3.73565154
52DNA ligation (GO:0006266)3.72892635
53regulation of double-strand break repair via homologous recombination (GO:0010569)3.71969525
54spliceosomal tri-snRNP complex assembly (GO:0000244)3.70554198
55negative regulation of mRNA processing (GO:0050686)3.64721134
56positive regulation of DNA repair (GO:0045739)3.64467342
57DNA strand elongation (GO:0022616)3.63974115
58mitochondrial RNA metabolic process (GO:0000959)3.62081495
59glutamine family amino acid biosynthetic process (GO:0009084)3.59438554
60nuclear pore organization (GO:0006999)3.58439909
61dosage compensation (GO:0007549)3.56462734
62positive regulation by host of viral transcription (GO:0043923)3.55631482
63maturation of 5.8S rRNA (GO:0000460)3.54830436
64protoporphyrinogen IX biosynthetic process (GO:0006782)3.54808885
65rRNA modification (GO:0000154)3.53571891
66cullin deneddylation (GO:0010388)3.53496440
67positive regulation of protein oligomerization (GO:0032461)3.52984881
68regulation of translational fidelity (GO:0006450)3.52272668
69non-recombinational repair (GO:0000726)3.48157493
70double-strand break repair via nonhomologous end joining (GO:0006303)3.48157493
71positive regulation of chromosome segregation (GO:0051984)3.46374755
72regulation of double-strand break repair (GO:2000779)3.43214269
73negative regulation of Ras GTPase activity (GO:0034261)3.39140879
74positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.37438827
75positive regulation of mitotic sister chromatid separation (GO:1901970)3.37438827
76positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.37438827
77face development (GO:0060324)3.36447457
78pyrimidine nucleotide catabolic process (GO:0006244)3.34501499
79trophectodermal cell differentiation (GO:0001829)3.33888672
80negative regulation of RNA splicing (GO:0033119)3.32993746
81porphyrin-containing compound biosynthetic process (GO:0006779)3.28515521
82protein deneddylation (GO:0000338)3.26323242
83mitotic recombination (GO:0006312)3.23881566
84negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.23642152
85negative regulation of fatty acid biosynthetic process (GO:0045717)3.20227533
86piRNA metabolic process (GO:0034587)3.20005048
87meiotic chromosome segregation (GO:0045132)3.19577453
88heme biosynthetic process (GO:0006783)3.19108463
89glial cell migration (GO:0008347)3.17919416
90DNA demethylation (GO:0080111)3.17503691
91kinetochore assembly (GO:0051382)3.17442244
92rRNA processing (GO:0006364)3.14955988
93regulation of protein oligomerization (GO:0032459)3.14223381
94negative regulation of protein oligomerization (GO:0032460)3.13985197
95telomere maintenance via telomere lengthening (GO:0010833)3.09905243
96histone arginine methylation (GO:0034969)3.09812170
97tetrapyrrole biosynthetic process (GO:0033014)3.08384046
98pore complex assembly (GO:0046931)3.07568483
99cellular response to zinc ion (GO:0071294)3.07055167
100DNA replication initiation (GO:0006270)3.06938009
101IMP biosynthetic process (GO:0006188)3.06534983
102DNA replication checkpoint (GO:0000076)3.05971659
103peptidyl-histidine modification (GO:0018202)3.05941967
104embryonic camera-type eye development (GO:0031076)3.04288456
105termination of RNA polymerase III transcription (GO:0006386)3.03256315
106transcription elongation from RNA polymerase III promoter (GO:0006385)3.03256315
107rRNA metabolic process (GO:0016072)3.02117225
108mRNA export from nucleus (GO:0006406)3.02026622
109negative regulation of tumor necrosis factor production (GO:0032720)3.01065318
110mitochondrial DNA replication (GO:0006264)3.00153031
111DNA topological change (GO:0006265)2.99664942
112branched-chain amino acid catabolic process (GO:0009083)2.99415006
113RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.98934663
114rRNA methylation (GO:0031167)2.98132832
115ubiquinone biosynthetic process (GO:0006744)2.97685921
116DNA unwinding involved in DNA replication (GO:0006268)2.97063910
117activation of Rac GTPase activity (GO:0032863)2.96727921
118regulation of RNA export from nucleus (GO:0046831)2.96259655
119pseudouridine synthesis (GO:0001522)2.95702836
120regulation of DNA repair (GO:0006282)2.94112059
121convergent extension (GO:0060026)2.93530230
122spliceosomal snRNP assembly (GO:0000387)2.92869363
123regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.91653133
124regulation of DNA damage checkpoint (GO:2000001)2.90413800
125ribosome assembly (GO:0042255)2.90019040
126nodal signaling pathway (GO:0038092)2.89534820
127negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.89472731
128regulation of mitochondrial translation (GO:0070129)2.89133983
129mitotic chromosome condensation (GO:0007076)2.88597081
130IMP metabolic process (GO:0046040)2.87910891
131regulation of nuclear cell cycle DNA replication (GO:0033262)2.86766699
132hemoglobin metabolic process (GO:0020027)2.83529152
133ribosome biogenesis (GO:0042254)2.83515006
134regulation of cilium movement (GO:0003352)2.83378256
135anterograde synaptic vesicle transport (GO:0048490)2.82912416
136chaperone-mediated protein transport (GO:0072321)2.81447495
137platelet dense granule organization (GO:0060155)2.78146507
138sister chromatid cohesion (GO:0007062)2.78027545
139mitotic sister chromatid segregation (GO:0000070)2.77000237
140somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.76577913
141isotype switching (GO:0045190)2.76577913
142somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.76577913
143folic acid-containing compound biosynthetic process (GO:0009396)2.75609911
144synapsis (GO:0007129)2.75570372
145somatic recombination of immunoglobulin gene segments (GO:0016447)2.74573190
146ncRNA processing (GO:0034470)2.74456912
147protein K6-linked ubiquitination (GO:0085020)2.73842814
148peptidyl-cysteine modification (GO:0018198)2.73007630
149somatic diversification of immunoglobulins (GO:0016445)2.70564512
150regulation of sister chromatid cohesion (GO:0007063)2.67488529
151respiratory chain complex IV assembly (GO:0008535)2.66707880
152pteridine-containing compound biosynthetic process (GO:0042559)2.66281613
153porphyrin-containing compound metabolic process (GO:0006778)2.64582167
154negative regulation of mRNA metabolic process (GO:1903312)2.64552984
155DNA catabolic process, exonucleolytic (GO:0000738)2.63283130
156nucleobase biosynthetic process (GO:0046112)2.62251558
157sister chromatid segregation (GO:0000819)2.61738447
158cellular ketone body metabolic process (GO:0046950)2.60582517
159ncRNA metabolic process (GO:0034660)2.60170407
160negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.57935241
161DNA-dependent DNA replication (GO:0006261)2.56648604
162ubiquinone metabolic process (GO:0006743)2.56547052
163ribonucleoprotein complex disassembly (GO:0032988)2.56283492
164tRNA processing (GO:0008033)2.54978536
165tRNA aminoacylation for protein translation (GO:0006418)2.54394264
166amino acid activation (GO:0043038)2.53828833
167tRNA aminoacylation (GO:0043039)2.53828833
168negative regulation of cell cycle G2/M phase transition (GO:1902750)2.53173473
169branched-chain amino acid metabolic process (GO:0009081)2.51672195
170tRNA metabolic process (GO:0006399)2.51087307
171lactate metabolic process (GO:0006089)2.48715537
172heme metabolic process (GO:0042168)2.46554045
173signal peptide processing (GO:0006465)2.46135937
174transcription-coupled nucleotide-excision repair (GO:0006283)2.42844094
175protein-cofactor linkage (GO:0018065)2.41561123

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_18555785_ChIP-Seq_MESCs_Mouse3.43376379
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.26420631
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.26420631
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.26420631
5E2F7_22180533_ChIP-Seq_HELA_Human3.06186701
6SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.01654494
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.79441878
8ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.72667758
9PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.69361804
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.67038429
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.63041871
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.57148429
13VDR_21846776_ChIP-Seq_THP-1_Human2.52497870
14FOXP3_21729870_ChIP-Seq_TREG_Human2.48112069
15RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.43305954
16FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.36297620
17GATA1_22025678_ChIP-Seq_K562_Human2.32269579
18ELK1_19687146_ChIP-ChIP_HELA_Human2.31549713
19* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.23245110
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.22610252
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.19839476
22E2F1_21310950_ChIP-Seq_MCF-7_Human2.16691078
23* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.12466790
24SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.10128098
25HOXB4_20404135_ChIP-ChIP_EML_Mouse2.08935878
26KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.08689813
27* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.08090183
28NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.07975526
29CIITA_25753668_ChIP-Seq_RAJI_Human1.99129911
30FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.95463129
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.95180672
32SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.90912487
33YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.89926224
34KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.89033319
35ETS1_20019798_ChIP-Seq_JURKAT_Human1.87427896
36* TFEB_21752829_ChIP-Seq_HELA_Human1.85955246
37PADI4_21655091_ChIP-ChIP_MCF-7_Human1.85024343
38NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.84797136
39STAT3_1855785_ChIP-Seq_MESCs_Mouse1.84414639
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.82068644
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.81379360
42POU5F1_16518401_ChIP-PET_MESCs_Mouse1.81300861
43TCF3_18692474_ChIP-Seq_MESCs_Mouse1.79958827
44ERG_20887958_ChIP-Seq_HPC-7_Mouse1.79424766
45SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.79332376
46PU.1_20513432_ChIP-Seq_Bcells_Mouse1.78905573
47* LXR_22292898_ChIP-Seq_THP-1_Human1.74672363
48FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.74346523
49PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.70210380
50MYC_22102868_ChIP-Seq_BL_Human1.70011011
51E2F1_18555785_ChIP-Seq_MESCs_Mouse1.68153047
52TCF3_18692474_ChIP-Seq_MEFs_Mouse1.62197846
53DCP1A_22483619_ChIP-Seq_HELA_Human1.60396073
54E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.60267671
55NANOG_21062744_ChIP-ChIP_HESCs_Human1.58547293
56NANOG_18555785_ChIP-Seq_MESCs_Mouse1.57880649
57SALL1_21062744_ChIP-ChIP_HESCs_Human1.57366108
58MYCN_18555785_ChIP-Seq_MESCs_Mouse1.56856087
59DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.56138795
60CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.54114310
61GABP_19822575_ChIP-Seq_HepG2_Human1.52195985
62TET1_21451524_ChIP-Seq_MESCs_Mouse1.50818150
63CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.50757526
64NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.50548316
65POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.50349063
66ERG_21242973_ChIP-ChIP_JURKAT_Human1.49963568
67KLF4_18555785_ChIP-Seq_MESCs_Mouse1.49801162
68E2F4_17652178_ChIP-ChIP_JURKAT_Human1.48737077
69GABP_17652178_ChIP-ChIP_JURKAT_Human1.48541932
70FOXM1_23109430_ChIP-Seq_U2OS_Human1.48336483
71CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.48235188
72PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.42863328
73POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.42628261
74TTF2_22483619_ChIP-Seq_HELA_Human1.41949163
75POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.40372149
76EST1_17652178_ChIP-ChIP_JURKAT_Human1.39767768
77* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.39130091
78POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.38692813
79ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.38522310
80GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.38008231
81ZNF263_19887448_ChIP-Seq_K562_Human1.36144494
82* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.36033067
83SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.35405224
84XRN2_22483619_ChIP-Seq_HELA_Human1.33412022
85CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.33232324
86FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.33026738
87CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.32795009
88NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.31751092
89ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30821866
90BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.29280322
91SRY_22984422_ChIP-ChIP_TESTIS_Rat1.29257064
92HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.28106490
93PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.27275542
94SOX2_18555785_ChIP-Seq_MESCs_Mouse1.27268226
95KDM5A_27292631_Chip-Seq_BREAST_Human1.26633576
96NOTCH1_21737748_ChIP-Seq_TLL_Human1.26355413
97NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.26080586
98STAT1_20625510_ChIP-Seq_HELA_Human1.25109518
99NELFA_20434984_ChIP-Seq_ESCs_Mouse1.23915173
100ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.23101566
101MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.22618764
102NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.21871543
103TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20767522
104SOX2_18692474_ChIP-Seq_MEFs_Mouse1.19077279
105* VDR_23849224_ChIP-Seq_CD4+_Human1.18936332
106MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18416891
107* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.18242005
108YY1_22570637_ChIP-Seq_MALME-3M_Human1.17565325
109TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.17530255
110RACK7_27058665_Chip-Seq_MCF-7_Human1.17412440
111ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17194086
112TBX5_21415370_ChIP-Seq_HL-1_Mouse1.16488611
113SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16362181
114RARB_24833708_ChIP-Seq_LIVER_Mouse1.15747637
115SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.14907658
116CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.14138723
117CREB1_15753290_ChIP-ChIP_HEK293T_Human1.13076998
118OCT4_18692474_ChIP-Seq_MEFs_Mouse1.12960543
119CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.12609922
120ETS1_21867929_ChIP-Seq_TH2_Mouse1.12159293
121KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.12020435
122SOX2_18692474_ChIP-Seq_MESCs_Mouse1.10692009
123ZFP281_27345836_Chip-Seq_ESCs_Mouse1.10439584
124MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.09975897
125GATA4_21415370_ChIP-Seq_HL-1_Mouse1.09942097
126RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.09674711
127SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.09435153
128NANOG_18692474_ChIP-Seq_MESCs_Mouse1.09306835
129FLI1_27457419_Chip-Seq_LIVER_Mouse1.08167290
130EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07790276
131ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07642081
132KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07497542
133CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.07405395
134ZNF274_21170338_ChIP-Seq_K562_Hela1.05138426
135MYC_18940864_ChIP-ChIP_HL60_Human0.97632578
136E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.96730148
137MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.86272315
138SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85753017
139ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85556863
140TP53_22573176_ChIP-Seq_HFKS_Human0.85324809
141AR_21909140_ChIP-Seq_LNCAP_Human0.85236836
142PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.78406457
143CHD1_26751641_Chip-Seq_LNCaP_Human0.78079496
144FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.75785310
145* FOXP1_21924763_ChIP-Seq_HESCs_Human0.74366672
146FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73556885
147ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.73447487
148SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.72602195
149SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.72116527
150CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.72112198
151SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.70941070
152SPI1_23547873_ChIP-Seq_NB4_Human0.69614752
153EGR1_19374776_ChIP-ChIP_THP-1_Human0.69027621

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication6.58092668
2MP0005171_absent_coat_pigmentation3.71570179
3MP0009278_abnormal_bone_marrow3.71490311
4MP0010030_abnormal_orbit_morphology3.68976804
5MP0003656_abnormal_erythrocyte_physiolo3.10807120
6MP0006035_abnormal_mitochondrial_morpho3.02657056
7MP0006036_abnormal_mitochondrial_physio3.00529181
8MP0003646_muscle_fatigue2.89263970
9MP0004147_increased_porphyrin_level2.86028061
10MP0003890_abnormal_embryonic-extraembry2.79348342
11MP0010094_abnormal_chromosome_stability2.74986256
12MP0005174_abnormal_tail_pigmentation2.59884088
13MP0004957_abnormal_blastocyst_morpholog2.53947697
14MP0005075_abnormal_melanosome_morpholog2.46084615
15MP0004133_heterotaxia2.43355381
16MP0008995_early_reproductive_senescence2.41068522
17MP0004233_abnormal_muscle_weight2.34450475
18MP0005451_abnormal_body_composition2.31350794
19MP0002009_preneoplasia2.20024705
20MP0008932_abnormal_embryonic_tissue2.16725289
21MP0008058_abnormal_DNA_repair2.14274080
22MP0005397_hematopoietic_system_phenotyp2.11225962
23MP0001545_abnormal_hematopoietic_system2.11225962
24MP0003786_premature_aging2.09888377
25MP0008877_abnormal_DNA_methylation2.04637756
26MP0003119_abnormal_digestive_system1.97150505
27MP0000749_muscle_degeneration1.94707131
28MP0002653_abnormal_ependyma_morphology1.94131204
29MP0000015_abnormal_ear_pigmentation1.92988849
30MP0008007_abnormal_cellular_replicative1.92661997
31MP0000490_abnormal_crypts_of1.92066801
32MP0003111_abnormal_nucleus_morphology1.80154641
33MP0003186_abnormal_redox_activity1.78976378
34MP0002249_abnormal_larynx_morphology1.78299625
35MP0001293_anophthalmia1.77547059
36MP0006072_abnormal_retinal_apoptosis1.76870716
37MP0002163_abnormal_gland_morphology1.76145262
38MP0000358_abnormal_cell_content/1.73707450
39MP0004145_abnormal_muscle_electrophysio1.70019462
40MP0003693_abnormal_embryo_hatching1.68527403
41MP0002837_dystrophic_cardiac_calcinosis1.67938380
42MP0002282_abnormal_trachea_morphology1.66760680
43MP0006292_abnormal_olfactory_placode1.58223689
44MP0002138_abnormal_hepatobiliary_system1.56455990
45MP0002877_abnormal_melanocyte_morpholog1.51595821
46MP0001697_abnormal_embryo_size1.51583937
47MP0003283_abnormal_digestive_organ1.50896478
48MP0002084_abnormal_developmental_patter1.50523381
49MP0005220_abnormal_exocrine_pancreas1.49852777
50MP0003077_abnormal_cell_cycle1.49761567
51MP0002822_catalepsy1.45460351
52MP0005076_abnormal_cell_differentiation1.44721664
53MP0002086_abnormal_extraembryonic_tissu1.43097608
54MP0003195_calcinosis1.42090546
55MP0002085_abnormal_embryonic_tissue1.40200549
56MP0001661_extended_life_span1.39833200
57MP0004036_abnormal_muscle_relaxation1.36623721
58MP0003787_abnormal_imprinting1.36184042
59MP0000371_diluted_coat_color1.36173685
60MP0003453_abnormal_keratinocyte_physiol1.34907041
61MP0010234_abnormal_vibrissa_follicle1.33546698
62MP0009697_abnormal_copulation1.32621082
63MP0003221_abnormal_cardiomyocyte_apopto1.28249551
64MP0010352_gastrointestinal_tract_polyps1.27608399
65MP0002095_abnormal_skin_pigmentation1.25721516
66MP0003828_pulmonary_edema1.25388876
67MP0001672_abnormal_embryogenesis/_devel1.25128602
68MP0005380_embryogenesis_phenotype1.25128602
69MP0010307_abnormal_tumor_latency1.24860595
70MP0005379_endocrine/exocrine_gland_phen1.24471638
71MP0000350_abnormal_cell_proliferation1.24199032
72MP0004197_abnormal_fetal_growth/weight/1.23101911
73MP0003567_abnormal_fetal_cardiomyocyte1.21985393
74MP0002132_abnormal_respiratory_system1.20604080
75MP0003943_abnormal_hepatobiliary_system1.19769424
76MP0000685_abnormal_immune_system1.18299196
77MP0003252_abnormal_bile_duct1.14558417
78MP0002019_abnormal_tumor_incidence1.11154621
79MP0006082_CNS_inflammation1.10924998
80MP0005330_cardiomyopathy1.08808375
81MP0003172_abnormal_lysosome_physiology1.07563406
82MP0004142_abnormal_muscle_tone1.07543000
83MP0000762_abnormal_tongue_morphology1.06974767
84MP0000470_abnormal_stomach_morphology1.06111265
85MP0003718_maternal_effect1.05851235
86MP0002075_abnormal_coat/hair_pigmentati1.05732569
87MP0002111_abnormal_tail_morphology1.01894168
88MP0000372_irregular_coat_pigmentation1.01799296
89MP0003136_yellow_coat_color1.01264265
90MP0004381_abnormal_hair_follicle1.01187767
91MP0002405_respiratory_system_inflammati1.01162463
92MP0000049_abnormal_middle_ear1.00643037
93MP0009333_abnormal_splenocyte_physiolog1.00172273
94MP0001730_embryonic_growth_arrest0.99841462
95MP0000759_abnormal_skeletal_muscle0.99191249
96MP0002080_prenatal_lethality0.98842515
97MP0001340_abnormal_eyelid_morphology0.98686526
98MP0005645_abnormal_hypothalamus_physiol0.98651876
99MP0000569_abnormal_digit_pigmentation0.98650123
100MP0000313_abnormal_cell_death0.97959451
101MP0003984_embryonic_growth_retardation0.96942241
102MP0008775_abnormal_heart_ventricle0.96828813
103MP0002928_abnormal_bile_duct0.96072148
104MP0002932_abnormal_joint_morphology0.95806476
105MP0003755_abnormal_palate_morphology0.95039381
106MP0003123_paternal_imprinting0.94823545
107MP0000579_abnormal_nail_morphology0.93786538
108MP0002269_muscular_atrophy0.93655263
109MP0002088_abnormal_embryonic_growth/wei0.93469096
110MP0004215_abnormal_myocardial_fiber0.93343784
111MP0002114_abnormal_axial_skeleton0.92740489
112MP0003300_gastrointestinal_ulcer0.91282063
113MP0001324_abnormal_eye_pigmentation0.90959999
114MP0002106_abnormal_muscle_physiology0.89733870
115MP0001145_abnormal_male_reproductive0.89033497
116MP0001186_pigmentation_phenotype0.88616115
117MP0002116_abnormal_craniofacial_bone0.86682109
118MP0004808_abnormal_hematopoietic_stem0.85256073
119MP0002751_abnormal_autonomic_nervous0.84945093
120MP0000639_abnormal_adrenal_gland0.84402003
121MP0000462_abnormal_digestive_system0.84133735
122MP0005084_abnormal_gallbladder_morpholo0.83269841
123MP0001348_abnormal_lacrimal_gland0.83074137
124MP0005266_abnormal_metabolism0.81857742
125MP0004087_abnormal_muscle_fiber0.81078160
126MP0000689_abnormal_spleen_morphology0.81055316
127MP0000678_abnormal_parathyroid_gland0.79408794
128MP0005083_abnormal_biliary_tract0.78721202
129MP0000747_muscle_weakness0.77532999
130MP0003137_abnormal_impulse_conducting0.75696449
131MP0009672_abnormal_birth_weight0.75378777
132MP0000653_abnormal_sex_gland0.75154684
133MP0009115_abnormal_fat_cell0.74719193
134MP0003935_abnormal_craniofacial_develop0.74385974
135MP0005310_abnormal_salivary_gland0.72357427
136MP0004264_abnormal_extraembryonic_tissu0.72243997
137MP0005058_abnormal_lysosome_morphology0.72092178
138MP0000432_abnormal_head_morphology0.70805619
139MP0002166_altered_tumor_susceptibility0.69504970
140MP0000598_abnormal_liver_morphology0.69101261
141MP0002210_abnormal_sex_determination0.69038408
142MP0000703_abnormal_thymus_morphology0.68812430
143MP0004185_abnormal_adipocyte_glucose0.68234765
144MP0005384_cellular_phenotype0.68186186
145MP0002796_impaired_skin_barrier0.67810591
146MP0001929_abnormal_gametogenesis0.67543158
147MP0005167_abnormal_blood-brain_barrier0.67207064
148MP0002396_abnormal_hematopoietic_system0.66574712
149MP0008260_abnormal_autophagy0.66231967
150MP0005508_abnormal_skeleton_morphology0.66231159
151MP0003806_abnormal_nucleotide_metabolis0.65548511
152MP0003763_abnormal_thymus_physiology0.63479610
153MP0002398_abnormal_bone_marrow0.60742434
154MP0002970_abnormal_white_adipose0.60388909
155MP0002332_abnormal_exercise_endurance0.59525339

Predicted human phenotypes

RankGene SetZ-score
1Concave nail (HP:0001598)6.36713995
2Rib fusion (HP:0000902)5.67083600
3Rectovaginal fistula (HP:0000143)5.21325199
4Rectal fistula (HP:0100590)5.21325199
5Increased IgM level (HP:0003496)5.14342267
6Pustule (HP:0200039)4.90792319
7Nemaline bodies (HP:0003798)4.76954392
8Muscle fiber inclusion bodies (HP:0100299)4.69491343
9Facial hemangioma (HP:0000329)4.60847943
10Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.53191553
11Vaginal fistula (HP:0004320)4.50395785
12Intestinal fistula (HP:0100819)4.50358214
13Poikiloderma (HP:0001029)4.45848497
14Abnormal hemoglobin (HP:0011902)4.37450886
15Aplasia/Hypoplasia involving the carpal bones (HP:0006502)4.37023089
16Annular pancreas (HP:0001734)4.33653135
17Hypochromic microcytic anemia (HP:0004840)4.19377114
18Tongue fasciculations (HP:0001308)4.00448250
19Abnormality of the heme biosynthetic pathway (HP:0010472)3.96694668
20Microvesicular hepatic steatosis (HP:0001414)3.91266546
21Alopecia of scalp (HP:0002293)3.80017376
22Aplasia/hypoplasia of the humerus (HP:0006507)3.66630570
23Short humerus (HP:0005792)3.62394853
24Muscle fibrillation (HP:0010546)3.51130699
25Absent radius (HP:0003974)3.49990651
26Abnormality of endocrine pancreas physiology (HP:0012093)3.48763621
27Abnormality of the pancreatic islet cells (HP:0006476)3.48763621
283-Methylglutaconic aciduria (HP:0003535)3.43439737
29Ulnar bowing (HP:0003031)3.42513098
30Turricephaly (HP:0000262)3.35457561
31Progressive muscle weakness (HP:0003323)3.28409763
32Aplasia involving forearm bones (HP:0009822)3.27226250
33Absent forearm bone (HP:0003953)3.27226250
34Intestinal atresia (HP:0011100)3.26002594
35Abnormality of male internal genitalia (HP:0000022)3.24909630
36Coronal craniosynostosis (HP:0004440)3.22414813
37Exercise-induced muscle cramps (HP:0003710)3.20560092
38Absent thumb (HP:0009777)3.20284437
39Type I transferrin isoform profile (HP:0003642)3.20194532
40Neoplasm of the adrenal cortex (HP:0100641)3.14833449
41Anteriorly placed anus (HP:0001545)3.04531383
42Chromsome breakage (HP:0040012)3.04356658
43Chromosomal breakage induced by crosslinking agents (HP:0003221)3.03740117
44Orthostatic hypotension (HP:0001278)3.03351504
45Albinism (HP:0001022)3.00317778
46Hypochromic anemia (HP:0001931)2.98227277
47Squamous cell carcinoma (HP:0002860)2.97126545
48Neoplasm of the adrenal gland (HP:0100631)2.96233796
49Hypokinesia (HP:0002375)2.94520464
50Broad alveolar ridges (HP:0000187)2.91883360
51Aplasia/Hypoplasia of the sacrum (HP:0008517)2.88478153
52Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.86477812
53Abnormal protein N-linked glycosylation (HP:0012347)2.86477812
54Abnormal protein glycosylation (HP:0012346)2.86477812
55Abnormal glycosylation (HP:0012345)2.86477812
56Cheilitis (HP:0100825)2.86097852
57Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.85642148
58Vertebral hypoplasia (HP:0008417)2.85642148
59Ketoacidosis (HP:0001993)2.83553474
60Abnormality of the aortic arch (HP:0012303)2.80463847
61Male infertility (HP:0003251)2.79825347
62Basal cell carcinoma (HP:0002671)2.78155193
63Microretrognathia (HP:0000308)2.76982099
64Abnormality of the left ventricular outflow tract (HP:0011103)2.74015293
65Subaortic stenosis (HP:0001682)2.74015293
66Selective tooth agenesis (HP:0001592)2.69158360
67Paralysis (HP:0003470)2.64040201
68Patellar aplasia (HP:0006443)2.63271424
69Dysautonomia (HP:0002459)2.61552759
70Muscle hypertrophy of the lower extremities (HP:0008968)2.59063993
71Capillary hemangiomas (HP:0005306)2.56774462
72Bifid uvula (HP:0000193)2.54663955
73Exercise-induced myalgia (HP:0003738)2.53706474
74Ketosis (HP:0001946)2.53097405
75Premature skin wrinkling (HP:0100678)2.52443726
76Premature graying of hair (HP:0002216)2.52127089
77Rhabdomyolysis (HP:0003201)2.50231535
78Aplasia/Hypoplasia of the patella (HP:0006498)2.49126741
79Congenital hip dislocation (HP:0001374)2.49111032
80Calf muscle hypertrophy (HP:0008981)2.46906481
81Short chin (HP:0000331)2.46877335
82Diaphragmatic weakness (HP:0009113)2.43221541
83Abnormal pancreas size (HP:0012094)2.42282659
84Choanal stenosis (HP:0000452)2.41985616
85Increased intramyocellular lipid droplets (HP:0012240)2.41761538
86Ragged-red muscle fibers (HP:0003200)2.41490500
87Aplasia of the musculature (HP:0100854)2.41404720
88Areflexia of lower limbs (HP:0002522)2.40938441
89Joint stiffness (HP:0001387)2.40381007
90Increased hepatocellular lipid droplets (HP:0006565)2.38537116
91Alacrima (HP:0000522)2.37417626
92Multiple enchondromatosis (HP:0005701)2.36216606
93Hamartoma (HP:0010566)2.34888025
94Increased number of teeth (HP:0011069)2.34310267
95Lipid accumulation in hepatocytes (HP:0006561)2.30482288
96Increased serum lactate (HP:0002151)2.30189606
97Redundant skin (HP:0001582)2.30044997
98Hyperinsulinemic hypoglycemia (HP:0000825)2.28927991
99Amelogenesis imperfecta (HP:0000705)2.27900770
100Rimmed vacuoles (HP:0003805)2.27394392
101Abnormality of alanine metabolism (HP:0010916)2.26273974
102Hyperalaninemia (HP:0003348)2.26273974
103Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.26273974
104Hypotrichosis (HP:0001006)2.25670244
105Mucopolysacchariduria (HP:0008155)2.25376569
106Urinary glycosaminoglycan excretion (HP:0003541)2.25376569
107Large for gestational age (HP:0001520)2.24619935
108Abnormality of the ileum (HP:0001549)2.23987291
109Hypoplasia of the radius (HP:0002984)2.23204889
110Volvulus (HP:0002580)2.22941458
111Abnormality of chromosome stability (HP:0003220)2.22093851
112Myoglobinuria (HP:0002913)2.20973929
113Vertebral fusion (HP:0002948)2.20580418
114Amniotic constriction ring (HP:0009775)2.19803278
115Abnormality of placental membranes (HP:0011409)2.19803278
116Cutaneous melanoma (HP:0012056)2.18829231
117Nephroblastoma (Wilms tumor) (HP:0002667)2.16381575
118Abnormal number of incisors (HP:0011064)2.16079206
119EMG: myopathic abnormalities (HP:0003458)2.15600922
120Muscle fiber atrophy (HP:0100295)2.15070101
121Acute necrotizing encephalopathy (HP:0006965)2.14980527
122Exertional dyspnea (HP:0002875)2.14365746
123Increased CSF lactate (HP:0002490)2.13342109
124Exercise intolerance (HP:0003546)2.13167394
125Lactic acidosis (HP:0003128)2.13155697
126Renal Fanconi syndrome (HP:0001994)2.12627985
127Dysostosis multiplex (HP:0000943)2.10947905
128Median cleft lip (HP:0000161)2.09286416
129Hypotelorism (HP:0000601)2.07757116
130Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.07706602
131Poikilocytosis (HP:0004447)2.07203090
132Progressive macrocephaly (HP:0004481)2.06487309
133Birth length less than 3rd percentile (HP:0003561)2.05258441
134Clumsiness (HP:0002312)2.02795317
135Ectopic anus (HP:0004397)2.02683611
136Increased muscle lipid content (HP:0009058)2.01393763
137Lower limb hyperreflexia (HP:0002395)2.00916774
138IgA deficiency (HP:0002720)2.00498841
139Acute lymphatic leukemia (HP:0006721)1.99650549
140Abnormal respiratory epithelium morphology (HP:0012253)1.99408034
141Abnormal respiratory motile cilium morphology (HP:0005938)1.99408034
142Spinal muscular atrophy (HP:0007269)1.99334342
143Abnormal mitochondria in muscle tissue (HP:0008316)1.97646104
144Embryonal renal neoplasm (HP:0011794)1.96007352
145Abnormality of the preputium (HP:0100587)1.95014792
146Abnormality of the labia minora (HP:0012880)1.94978998
147Short 5th finger (HP:0009237)1.94814660
148Mitochondrial inheritance (HP:0001427)1.93047016
149Difficulty running (HP:0009046)1.93034777
150Abnormality of mucopolysaccharide metabolism (HP:0011020)1.92777608
151Abnormality of polysaccharide metabolism (HP:0011012)1.92777608
152Abnormality of glycosaminoglycan metabolism (HP:0004371)1.92777608
153Bowed forearm bones (HP:0003956)1.92643593
154Bowing of the arm (HP:0006488)1.92643593
155Type 2 muscle fiber atrophy (HP:0003554)1.92170379
156Decreased lacrimation (HP:0000633)1.90570751
157Bulbar palsy (HP:0001283)1.90298411
158Testicular atrophy (HP:0000029)1.89370651
159Myopathic facies (HP:0002058)1.88815055
160Cerebral edema (HP:0002181)1.88610494
161Acute encephalopathy (HP:0006846)1.87150071
162Pancreatic islet-cell hyperplasia (HP:0004510)1.86507924
163Popliteal pterygium (HP:0009756)1.86367488
164Conjunctival hamartoma (HP:0100780)1.86316452
165Small hand (HP:0200055)1.85245604
166Hypoplasia of the ulna (HP:0003022)1.84947513
167Abnormality of methionine metabolism (HP:0010901)1.83778932
168Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.83437244
169Abnormality of the lower motor neuron (HP:0002366)1.83014097
170Progressive external ophthalmoplegia (HP:0000590)1.82963477
171Embryonal neoplasm (HP:0002898)1.80737337
172Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.80212122
173Bundle branch block (HP:0011710)1.78197794
174Prominent metopic ridge (HP:0005487)1.78133359
175Reduced antithrombin III activity (HP:0001976)1.77604497
176Progressive microcephaly (HP:0000253)1.76571831
177Dysphonia (HP:0001618)1.76555162
178Breast carcinoma (HP:0003002)1.73693318
179Ectopic kidney (HP:0000086)1.73316567
180Hyperkalemia (HP:0002153)1.71914866
181Aplasia/Hypoplasia of the uvula (HP:0010293)1.71089285
182Cholelithiasis (HP:0001081)1.70861683
183Meckel diverticulum (HP:0002245)1.64733323
184Abnormality of the pons (HP:0007361)1.64617644
185Abnormal gallbladder morphology (HP:0012437)1.64050782
186Type II lissencephaly (HP:0007260)1.64012061
187Hepatoblastoma (HP:0002884)1.62723761
188Hypoplasia of the pons (HP:0012110)1.62120050
189Neonatal hypoglycemia (HP:0001998)1.59579298
190Horseshoe kidney (HP:0000085)1.58460580
191Hyperglycemia (HP:0003074)1.58045649
192Methylmalonic acidemia (HP:0002912)1.57490782
193Enlarged kidneys (HP:0000105)1.57403146

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.54194817
2MAPK154.89848801
3MAP3K64.63245199
4DDR24.44436772
5MAP3K113.73022133
6TIE13.38148295
7PINK13.31746647
8MATK3.25062327
9ZAK3.23708769
10SCYL23.13452532
11OBSCN3.08059443
12PIM22.99042641
13TYRO32.95515299
14FRK2.81867062
15FGR2.70071108
16DAPK12.53676493
17PRKD22.50834168
18DYRK1B2.38455437
19NUAK12.34196731
20EIF2AK32.34037644
21UHMK12.33974199
22CSK2.27446034
23YES12.26591550
24BMPR1B2.06740695
25BMX1.92441524
26CDK71.91522935
27BRSK21.70038941
28PLK31.67747300
29TAF11.61330277
30PIM11.60738515
31PBK1.58842302
32CLK11.56767926
33TNIK1.51473216
34PDGFRA1.50918656
35AKT31.46805139
36ADRBK21.40318345
37MAP3K71.37233940
38STK41.37114966
39PLK41.36509156
40DYRK31.34999925
41CHEK21.25944443
42MUSK1.20902070
43PASK1.20182571
44STK161.19857102
45CDK61.18220536
46MAP3K101.12961787
47RPS6KL11.10875169
48RPS6KC11.10875169
49PLK11.06155820
50LATS21.04711940
51MAP2K31.02969036
52NEK11.02654066
53TSSK61.00246897
54MST40.98103372
55BRSK10.97198471
56TLK10.96853536
57MAPK110.95524384
58CDK120.93667992
59GSK3A0.93053169
60RPS6KA60.92979315
61TRPM70.91373437
62DYRK20.90297962
63HIPK20.89584017
64PIK3CG0.89252172
65PRPF4B0.88524764
66MAP3K140.82892067
67LIMK10.82644576
68BRD40.81511824
69CDC42BPA0.81476617
70CAMK1D0.80303294
71WEE10.79259746
72WNK10.78269341
73TAOK20.78005668
74CDK90.77406761
75INSRR0.76772996
76MAP3K130.75932033
77MARK30.75749105
78BUB10.74661584
79GRK10.72506086
80NME20.71005865
81CCNB10.70908718
82CAMK1G0.70832883
83PRKCI0.70475825
84VRK20.70005267
85TGFBR10.69321371
86CDK190.68058488
87PLK20.65953326
88AURKA0.65739157
89TTN0.64844943
90MAP3K20.63570580
91ACVR1B0.61646714
92RPS6KA10.58466341
93GRK60.58317656
94SRPK10.57523023
95RAF10.56793007
96TESK20.56768504
97LYN0.56335739
98CSNK2A10.56264301
99PHKG20.53643688
100PHKG10.53643688
101VRK10.51021777
102CDK20.50183414
103TTK0.49674163
104STK38L0.49204205
105CDC70.47040498
106ATR0.46991420
107EIF2AK10.45898491
108MAPK40.45365673
109STK30.44676566
110NEK20.43307140
111MAP2K10.42266487
112IRAK30.42210239
113PRKAA10.41978939
114TEC0.41858075
115BRAF0.40830601
116CDK80.40779425
117CSNK2A20.40731199
118AKT20.40270974
119IKBKB0.38272063
120RPS6KB10.38223737
121MTOR0.37502672
122EIF2AK20.37305011
123NME10.37258999
124MARK20.36276217
125ERBB30.36225952
126MKNK20.35823542
127CAMKK20.35728162
128CAMK2B0.35270518
129MKNK10.34445710
130MAP3K80.34136686
131CHEK10.32273674
132OXSR10.31847776
133PRKCH0.31776577
134MELK0.31645645
135CAMK2G0.31615649
136AURKB0.31371615
137MAPK30.30933661
138CDK11A0.30590647
139CDK40.30536074
140FLT30.29301546
141MAPK10.28820600
142EGFR0.27964760
143EPHA20.27928826
144PRKCD0.27908654
145CDK150.26862817
146BCKDK0.26696133
147LCK0.26661048
148ATM0.26651689
149CSNK1G10.25239073
150CDK180.24860882
151MAP4K10.24602972
152MAPK100.23602945
153ALK0.23540006
154PRKCZ0.22454432
155SIK20.21379896
156PAK10.20701775
157MAPKAPK20.20587880
158MAPK140.19718512
159CDK10.19351433
160CDK140.18608240
161PRKAA20.15792244

Predicted pathways (KEGG)

RankGene SetZ-score
1Base excision repair_Homo sapiens_hsa034105.19960551
2Mismatch repair_Homo sapiens_hsa034304.91517321
3DNA replication_Homo sapiens_hsa030304.79520708
4Fatty acid biosynthesis_Homo sapiens_hsa000613.90109509
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.88591897
6Nucleotide excision repair_Homo sapiens_hsa034202.83411209
7Ribosome_Homo sapiens_hsa030102.74655771
8Spliceosome_Homo sapiens_hsa030402.72887131
9Homologous recombination_Homo sapiens_hsa034402.54836304
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.51403646
11Non-homologous end-joining_Homo sapiens_hsa034502.49462329
12Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.31735648
13RNA transport_Homo sapiens_hsa030132.30469274
14Propanoate metabolism_Homo sapiens_hsa006402.20559760
15mRNA surveillance pathway_Homo sapiens_hsa030152.20072375
16Protein export_Homo sapiens_hsa030602.19385294
17Fanconi anemia pathway_Homo sapiens_hsa034602.16550413
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.90152022
19RNA polymerase_Homo sapiens_hsa030201.88404973
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.85057340
21Sulfur relay system_Homo sapiens_hsa041221.79568141
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.73589128
23p53 signaling pathway_Homo sapiens_hsa041151.61364332
24Hedgehog signaling pathway_Homo sapiens_hsa043401.60639177
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.56051168
26Arginine and proline metabolism_Homo sapiens_hsa003301.56014226
27Cell cycle_Homo sapiens_hsa041101.55402244
28Folate biosynthesis_Homo sapiens_hsa007901.55096847
29Selenocompound metabolism_Homo sapiens_hsa004501.53341167
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.53066735
31Notch signaling pathway_Homo sapiens_hsa043301.51405016
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.50990858
33Proteasome_Homo sapiens_hsa030501.47523217
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.46046289
35Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.43417554
36Circadian rhythm_Homo sapiens_hsa047101.41886904
37mTOR signaling pathway_Homo sapiens_hsa041501.39912003
38Hippo signaling pathway_Homo sapiens_hsa043901.38367254
39Butanoate metabolism_Homo sapiens_hsa006501.36266095
40Pyrimidine metabolism_Homo sapiens_hsa002401.29235660
41Shigellosis_Homo sapiens_hsa051311.23428811
42Regulation of autophagy_Homo sapiens_hsa041401.22762740
43Pyruvate metabolism_Homo sapiens_hsa006201.17305917
44Wnt signaling pathway_Homo sapiens_hsa043101.15878153
45Transcriptional misregulation in cancer_Homo sapiens_hsa052021.15170729
46Bladder cancer_Homo sapiens_hsa052191.15157949
47Primary immunodeficiency_Homo sapiens_hsa053401.12419899
48TGF-beta signaling pathway_Homo sapiens_hsa043501.07438005
49Adherens junction_Homo sapiens_hsa045201.04688995
50Carbon metabolism_Homo sapiens_hsa012001.01471975
51One carbon pool by folate_Homo sapiens_hsa006700.99355638
52Biosynthesis of amino acids_Homo sapiens_hsa012300.95467102
53Basal transcription factors_Homo sapiens_hsa030220.93099433
54Longevity regulating pathway - mammal_Homo sapiens_hsa042110.92616236
55VEGF signaling pathway_Homo sapiens_hsa043700.92554111
56Oocyte meiosis_Homo sapiens_hsa041140.91288299
57Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.84133273
58Fructose and mannose metabolism_Homo sapiens_hsa000510.83038615
59Thyroid cancer_Homo sapiens_hsa052160.81728980
60Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.81269778
61Basal cell carcinoma_Homo sapiens_hsa052170.80965107
62Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80826726
63RNA degradation_Homo sapiens_hsa030180.77771622
64Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73984111
65Legionellosis_Homo sapiens_hsa051340.69408130
66Maturity onset diabetes of the young_Homo sapiens_hsa049500.69248637
67Fatty acid elongation_Homo sapiens_hsa000620.67100547
68Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66169646
69Acute myeloid leukemia_Homo sapiens_hsa052210.63474918
70Vitamin B6 metabolism_Homo sapiens_hsa007500.62933293
71Epstein-Barr virus infection_Homo sapiens_hsa051690.61810574
72Fatty acid degradation_Homo sapiens_hsa000710.61655312
73Colorectal cancer_Homo sapiens_hsa052100.61275151
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.60934807
75Alzheimers disease_Homo sapiens_hsa050100.59744066
76Nitrogen metabolism_Homo sapiens_hsa009100.58544382
77Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57942142
78Metabolic pathways_Homo sapiens_hsa011000.56858529
79Herpes simplex infection_Homo sapiens_hsa051680.56212452
80Non-small cell lung cancer_Homo sapiens_hsa052230.55835926
81Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.53651775
82Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52556608
83Glycosaminoglycan degradation_Homo sapiens_hsa005310.49836761
84Insulin resistance_Homo sapiens_hsa049310.48907160
85Pentose phosphate pathway_Homo sapiens_hsa000300.48448199
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48180098
87Cardiac muscle contraction_Homo sapiens_hsa042600.47936504
88Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.47928565
89Huntingtons disease_Homo sapiens_hsa050160.47069713
90Viral carcinogenesis_Homo sapiens_hsa052030.46034479
91MicroRNAs in cancer_Homo sapiens_hsa052060.45390498
92Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.45378413
93ErbB signaling pathway_Homo sapiens_hsa040120.45145292
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43977811
95Choline metabolism in cancer_Homo sapiens_hsa052310.43805115
96Peroxisome_Homo sapiens_hsa041460.43674439
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42739324
98Pancreatic cancer_Homo sapiens_hsa052120.42724615
99Galactose metabolism_Homo sapiens_hsa000520.41506555
100SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39218674
101FoxO signaling pathway_Homo sapiens_hsa040680.38668987
102Hepatitis B_Homo sapiens_hsa051610.38269234
103Purine metabolism_Homo sapiens_hsa002300.36517854
104Type II diabetes mellitus_Homo sapiens_hsa049300.35915133
105Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.34989179
106Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33770013
107Lysine degradation_Homo sapiens_hsa003100.33736967
108Inositol phosphate metabolism_Homo sapiens_hsa005620.33011101
109B cell receptor signaling pathway_Homo sapiens_hsa046620.32390826
110Phototransduction_Homo sapiens_hsa047440.32248060
111Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.31868862
112Glucagon signaling pathway_Homo sapiens_hsa049220.31425940
113Parkinsons disease_Homo sapiens_hsa050120.30924828
114Gap junction_Homo sapiens_hsa045400.29611146
115HTLV-I infection_Homo sapiens_hsa051660.29330954
116Endometrial cancer_Homo sapiens_hsa052130.26892178
117T cell receptor signaling pathway_Homo sapiens_hsa046600.26829362
118Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26716334
119RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.26436189
120Viral myocarditis_Homo sapiens_hsa054160.25487065
121Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.24923585
122Arachidonic acid metabolism_Homo sapiens_hsa005900.24317481
123Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.24131917
124Chronic myeloid leukemia_Homo sapiens_hsa052200.23473586
125MAPK signaling pathway_Homo sapiens_hsa040100.23145776
126Tight junction_Homo sapiens_hsa045300.22842927
127Dorso-ventral axis formation_Homo sapiens_hsa043200.22657451
128N-Glycan biosynthesis_Homo sapiens_hsa005100.22508948
129AMPK signaling pathway_Homo sapiens_hsa041520.22212451
130Jak-STAT signaling pathway_Homo sapiens_hsa046300.21730326
1312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.21281270
132Oxidative phosphorylation_Homo sapiens_hsa001900.21076427
133Linoleic acid metabolism_Homo sapiens_hsa005910.20948848
134Prostate cancer_Homo sapiens_hsa052150.20470403
135Cysteine and methionine metabolism_Homo sapiens_hsa002700.17553817
136Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.17202348
137PI3K-Akt signaling pathway_Homo sapiens_hsa041510.16084438
138Sphingolipid signaling pathway_Homo sapiens_hsa040710.15761019
139Insulin signaling pathway_Homo sapiens_hsa049100.15365313
140Pathways in cancer_Homo sapiens_hsa052000.13948973
141Fatty acid metabolism_Homo sapiens_hsa012120.12976947
142Glutathione metabolism_Homo sapiens_hsa004800.12677264

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