SRPX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a secreted protein that contains three sushi repeat motifs. The encoded protein may play a role in the development of speech and language centers in the brain. This protein may also be involved in angiogenesis. Mutations in this gene are the cause of bilateral perisylvian polymicrogyria, rolandic epilepsy, speech dyspraxia and mental retardation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)9.05271280
2collagen fibril organization (GO:0030199)7.90665552
3extracellular fibril organization (GO:0043206)6.54823829
4sequestering of extracellular ligand from receptor (GO:0035581)6.41553772
5dermatan sulfate biosynthetic process (GO:0030208)6.21465012
6peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)5.90154697
7fibril organization (GO:0097435)5.88572500
8skin morphogenesis (GO:0043589)5.86624941
9bone trabecula formation (GO:0060346)5.79707991
10keratan sulfate catabolic process (GO:0042340)5.74766441
11dermatan sulfate metabolic process (GO:0030205)5.63165812
12chondrocyte proliferation (GO:0035988)5.57237563
13collagen metabolic process (GO:0032963)5.10287037
14collagen catabolic process (GO:0030574)4.92203028
15multicellular organismal macromolecule metabolic process (GO:0044259)4.78872069
16cellular response to vitamin (GO:0071295)4.72989184
17endodermal cell differentiation (GO:0035987)4.64167857
18multicellular organismal metabolic process (GO:0044236)4.55999824
19multicellular organismal catabolic process (GO:0044243)4.52838397
20negative regulation of chondrocyte differentiation (GO:0032331)4.28844015
21mesenchymal-epithelial cell signaling (GO:0060638)4.22673890
22extracellular matrix disassembly (GO:0022617)4.17642812
23regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.16450190
24response to gravity (GO:0009629)4.15366715
25cellular response to vitamin D (GO:0071305)4.00518823
26maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.92422563
27opsonization (GO:0008228)3.92338704
28wound healing, spreading of epidermal cells (GO:0035313)3.91660801
29protein retention in ER lumen (GO:0006621)3.90671695
30peptidyl-proline hydroxylation (GO:0019511)3.90308567
31extracellular matrix assembly (GO:0085029)3.89482814
32negative regulation of biomineral tissue development (GO:0070168)3.86242416
33metanephric mesenchyme development (GO:0072075)3.74596298
34retina vasculature morphogenesis in camera-type eye (GO:0061299)3.73082561
35endothelial cell morphogenesis (GO:0001886)3.71601064
36extracellular matrix organization (GO:0030198)3.69438054
37positive regulation of osteoblast proliferation (GO:0033690)3.68634974
38extracellular structure organization (GO:0043062)3.67850499
39basement membrane organization (GO:0071711)3.62407929
40chondroitin sulfate biosynthetic process (GO:0030206)3.59774881
41protein hydroxylation (GO:0018126)3.58634079
42positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.55653920
43cell adhesion mediated by integrin (GO:0033627)3.52943042
44negative regulation of cartilage development (GO:0061037)3.52343307
45regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.46012016
46extracellular regulation of signal transduction (GO:1900115)3.44939016
47extracellular negative regulation of signal transduction (GO:1900116)3.44939016
48craniofacial suture morphogenesis (GO:0097094)3.42743715
49cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.39544761
50kidney mesenchyme development (GO:0072074)3.35853124
51regulation of tight junction assembly (GO:2000810)3.33660369
52regulation of metalloenzyme activity (GO:0048552)3.32491787
53regulation of gonadotropin secretion (GO:0032276)3.31224244
54lymphangiogenesis (GO:0001946)3.31156467
55substrate adhesion-dependent cell spreading (GO:0034446)3.30493149
56tooth mineralization (GO:0034505)3.28343460
57chondroitin sulfate catabolic process (GO:0030207)3.22367730
58substrate-dependent cell migration (GO:0006929)3.22192921
59regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.18649024
60axon extension involved in axon guidance (GO:0048846)3.18488757
61neuron projection extension involved in neuron projection guidance (GO:1902284)3.18488757
62positive regulation of endothelial cell apoptotic process (GO:2000353)3.17661684
63negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.17198293
64short-term memory (GO:0007614)3.16951737
65barbed-end actin filament capping (GO:0051016)3.15821968
66cell migration involved in heart development (GO:0060973)3.15800794
67negative regulation of axon extension involved in axon guidance (GO:0048843)3.15659323
68protein trimerization (GO:0070206)3.14682595
69apoptotic cell clearance (GO:0043277)3.12307510
70negative regulation of smooth muscle cell migration (GO:0014912)3.11688178
71virion attachment to host cell (GO:0019062)3.10492758
72adhesion of symbiont to host cell (GO:0044650)3.10492758
73protein targeting to plasma membrane (GO:0072661)3.08118912
74mesodermal cell differentiation (GO:0048333)3.06457992
75hemidesmosome assembly (GO:0031581)3.06213634
76type B pancreatic cell proliferation (GO:0044342)3.05262524
77chondrocyte development (GO:0002063)3.04844791
78wound healing, spreading of cells (GO:0044319)3.02422130
79regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.01215533
80sprouting angiogenesis (GO:0002040)3.00997684
81muscle cell migration (GO:0014812)3.00284485
82regulation of macrophage cytokine production (GO:0010935)2.98276957
83cellular response to amino acid stimulus (GO:0071230)2.98090665
84regulation of chondrocyte differentiation (GO:0032330)2.95030772
85positive regulation of epithelial to mesenchymal transition (GO:0010718)2.94653937
86epithelial cell-cell adhesion (GO:0090136)2.93966070
87endothelial cell proliferation (GO:0001935)2.93935482
88glycosaminoglycan catabolic process (GO:0006027)2.93461568
89cell-substrate junction assembly (GO:0007044)2.92850596
90regulation of axon extension involved in axon guidance (GO:0048841)2.92616511
91regulation of cartilage development (GO:0061035)2.91600781
92positive regulation of macrophage cytokine production (GO:0060907)2.91548705
93trabecula formation (GO:0060343)2.91275155
94cellular response to nutrient (GO:0031670)2.90320631
95glomerular basement membrane development (GO:0032836)2.87201410
96negative regulation of nitric-oxide synthase activity (GO:0051001)2.85954792
97smooth muscle tissue development (GO:0048745)2.84937232
98atrioventricular valve morphogenesis (GO:0003181)2.84775929
99regulation of integrin-mediated signaling pathway (GO:2001044)2.84570992
100protein localization to cell surface (GO:0034394)2.84029363
101Golgi transport vesicle coating (GO:0048200)2.83514304
102COPI coating of Golgi vesicle (GO:0048205)2.83514304
103positive regulation of cartilage development (GO:0061036)2.82585326
104vascular endothelial growth factor signaling pathway (GO:0038084)2.82383396
105cranial suture morphogenesis (GO:0060363)2.81331908
106vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.81316334
107endocrine hormone secretion (GO:0060986)2.81025742
108wound healing (GO:0042060)2.80460127
109aminoglycan catabolic process (GO:0006026)2.79637773
110positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.77892568
111glycosaminoglycan biosynthetic process (GO:0006024)2.76752111
112COPII vesicle coating (GO:0048208)2.76467034
113endocardial cushion development (GO:0003197)2.75166295
114sulfur compound catabolic process (GO:0044273)2.74976044
115positive regulation of macrophage activation (GO:0043032)2.74650634
116negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.74592452
117aminoglycan biosynthetic process (GO:0006023)2.72906659
118membrane raft organization (GO:0031579)2.71722200
119* positive regulation of blood vessel endothelial cell migration (GO:0043536)2.70176549
120positive regulation of extracellular matrix organization (GO:1903055)2.69755360
121negative regulation of anoikis (GO:2000811)2.69000561
122blood vessel maturation (GO:0001955)2.68645116
123ossification (GO:0001503)2.68497071
124positive regulation of fatty acid oxidation (GO:0046321)2.68400858
125cell-substrate adhesion (GO:0031589)2.67842611
126cell migration involved in sprouting angiogenesis (GO:0002042)2.67581703
127epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.67534057
128regulation of transforming growth factor beta2 production (GO:0032909)2.66141459
129regulation of extracellular matrix disassembly (GO:0010715)2.65937518
130positive regulation of fibroblast migration (GO:0010763)2.65497282
131* positive regulation of endothelial cell migration (GO:0010595)2.65322177
132cardiac epithelial to mesenchymal transition (GO:0060317)2.64494900
133plasma membrane repair (GO:0001778)2.63622788
134regulation of plasminogen activation (GO:0010755)2.63615036
135venous blood vessel morphogenesis (GO:0048845)2.63274474
136endothelium development (GO:0003158)2.62943184
137cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.62809177
138regulation of smooth muscle cell migration (GO:0014910)2.62757912
139negative regulation of fatty acid transport (GO:2000192)2.61680881
140positive regulation of receptor recycling (GO:0001921)2.61067687
141cell-matrix adhesion (GO:0007160)2.60422560

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human8.31590741
2RARG_19884340_ChIP-ChIP_MEFs_Mouse5.22496048
3PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse4.85854881
4TP63_17297297_ChIP-ChIP_HaCaT_Human4.18965390
5CLOCK_20551151_ChIP-Seq_293T_Human3.20948407
6TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human3.17959986
7CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.98447733
8RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.94492788
9CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.88260735
10CJUN_26792858_Chip-Seq_BT549_Human2.87970133
11ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.68143544
12WT1_19549856_ChIP-ChIP_CCG9911_Human2.64691059
13NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.33451928
14NRF2_20460467_ChIP-Seq_MEFs_Mouse2.33451928
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.33163078
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.28979220
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.25393274
18EP300_21415370_ChIP-Seq_HL-1_Mouse2.08876740
19TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.05804047
20BRD4_25478319_ChIP-Seq_HGPS_Human2.05485446
21SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.93729104
22ESR1_21235772_ChIP-Seq_MCF-7_Human1.89340171
23EED_16625203_ChIP-ChIP_MESCs_Mouse1.83890070
24SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.82638456
25TP53_18474530_ChIP-ChIP_U2OS_Human1.76591655
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.73825664
27HIF1A_21447827_ChIP-Seq_MCF-7_Human1.67078894
28CDX2_19796622_ChIP-Seq_MESCs_Mouse1.66104258
29WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.61899189
30SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.59718681
31PPAR_26484153_Chip-Seq_NCI-H1993_Human1.59650368
32JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.58898507
33EZH2_18974828_ChIP-Seq_MESCs_Mouse1.57461689
34RNF2_18974828_ChIP-Seq_MESCs_Mouse1.57461689
35* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.54336222
36SMC1_22415368_ChIP-Seq_MEFs_Mouse1.53768877
37SOX2_20726797_ChIP-Seq_SW620_Human1.53444671
38SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.52857148
39* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.51191821
40EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.50486341
41SALL4_18804426_ChIP-ChIP_XEN_Mouse1.49919914
42TP53_20018659_ChIP-ChIP_R1E_Mouse1.43984827
43GATA2_21666600_ChIP-Seq_HMVEC_Human1.43177493
44CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.42521868
45SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.41550161
46BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.35442294
47NFIB_24661679_ChIP-Seq_LUNG_Mouse1.34764160
48RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.33197104
49SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.32529050
50SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.32529050
51MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.28931540
52TBX20_22328084_ChIP-Seq_HEART_Mouse1.26870664
53TBX20_22080862_ChIP-Seq_HEART_Mouse1.26870664
54TP53_16413492_ChIP-PET_HCT116_Human1.24748965
55ELK3_25401928_ChIP-Seq_HUVEC_Human1.23832124
56SMC3_22415368_ChIP-Seq_MEFs_Mouse1.22972960
57P300_27058665_Chip-Seq_ZR-75-30cells_Human1.20192586
58ESR2_21235772_ChIP-Seq_MCF-7_Human1.19930014
59SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.18512919
60SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.18455161
61NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.17693977
62NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.17489110
63KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.17084104
64UBF1/2_26484160_Chip-Seq_HMECs_Human1.15193624
65TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.13496206
66TP53_23651856_ChIP-Seq_MEFs_Mouse1.12615083
67PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.09957958
68PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.09210379
69AHR_22903824_ChIP-Seq_MCF-7_Human1.08494304
70JARID2_20075857_ChIP-Seq_MESCs_Mouse1.08472663
71Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.07804100
72SOX9_24532713_ChIP-Seq_HFSC_Mouse1.06928852
73EGR1_19374776_ChIP-ChIP_THP-1_Human1.06475082
74RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.06449253
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.05475990
76ESR1_20079471_ChIP-ChIP_T-47D_Human1.04750279
77GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.04056661
78AR_21572438_ChIP-Seq_LNCaP_Human1.03362258
79MTF2_20144788_ChIP-Seq_MESCs_Mouse1.02718522
80CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02415414
81UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.02361925
82DROSHA_22980978_ChIP-Seq_HELA_Human1.01863184
83NFI_21473784_ChIP-Seq_ESCs_Mouse1.00973315
84SA1_22415368_ChIP-Seq_MEFs_Mouse1.00370581
85ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00121629
86STAT6_21828071_ChIP-Seq_BEAS2B_Human0.97398742
87CSB_26484114_Chip-Seq_FIBROBLAST_Human0.96478122
88SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.95650106
89HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.95124416
90PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.94857092
91ATF3_27146783_Chip-Seq_COLON_Human0.93783508
92FOXO3_23340844_ChIP-Seq_DLD1_Human0.93027398
93NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.92572661
94* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.91875739
95CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.89791492
96LXR_22158963_ChIP-Seq_LIVER_Mouse0.89509869
97RXR_22158963_ChIP-Seq_LIVER_Mouse0.88703215
98TP63_23658742_ChIP-Seq_EP156T_Human0.84535217
99ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.83972899
100ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.83830414
101ISL1_27105846_Chip-Seq_CPCs_Mouse0.83610913
102ARNT_22903824_ChIP-Seq_MCF-7_Human0.83606237
103TP53_22127205_ChIP-Seq_IMR90_Human0.83592697
104RBPJ_22232070_ChIP-Seq_NCS_Mouse0.83075372
105BCAT_22108803_ChIP-Seq_LS180_Human0.83039397
106PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.82803324
107FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.82762818
108RAD21_21589869_ChIP-Seq_MESCs_Mouse0.82141303
109* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.81551516
110TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.80442626
111EZH2_27304074_Chip-Seq_ESCs_Mouse0.80335656
112WT1_25993318_ChIP-Seq_PODOCYTE_Human0.80140640
113TCF4_18268006_ChIP-ChIP_LS174T_Human0.80010774
114FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.79661029
115PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.78975094
116AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.78439313
117ZFP281_18757296_ChIP-ChIP_E14_Mouse0.77403475
118ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.77068581
119THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.76829707
120TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.75969652

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005503_abnormal_tendon_morphology7.24203989
2MP0005275_abnormal_skin_tensile6.77615079
3MP0003279_aneurysm3.78711335
4MP0003705_abnormal_hypodermis_morpholog3.76524349
5MP0001958_emphysema3.74159645
6MP0003950_abnormal_plasma_membrane3.10123564
7MP0001542_abnormal_bone_strength2.98670861
8MP0009780_abnormal_chondrocyte_physiolo2.64331093
9MP0002108_abnormal_muscle_morphology2.48141114
10MP0002060_abnormal_skin_morphology2.39577085
11MP0009384_cardiac_valve_regurgitation2.38009722
12MP0004272_abnormal_basement_membrane2.36906916
13MP0005508_abnormal_skeleton_morphology2.23682388
14MP0006054_spinal_hemorrhage2.13365699
15MP0008438_abnormal_cutaneous_collagen10.3060242
16MP0005257_abnormal_intraocular_pressure1.86128657
17MP0003566_abnormal_cell_adhesion1.84731346
18MP0002295_abnormal_pulmonary_circulatio1.73228157
19MP0001243_abnormal_dermal_layer1.63642151
20MP0004185_abnormal_adipocyte_glucose1.61278701
21MP0009250_abnormal_appendicular_skeleto1.59384083
22MP0002933_joint_inflammation1.57648126
23MP0005623_abnormal_meninges_morphology1.57471552
24MP0005023_abnormal_wound_healing1.54414182
25MP0000751_myopathy1.54112674
26MP0010030_abnormal_orbit_morphology1.52197956
27MP0010368_abnormal_lymphatic_system1.47731220
28MP0002896_abnormal_bone_mineralization1.47053577
29MP0005390_skeleton_phenotype1.46484291
30MP0000013_abnormal_adipose_tissue1.35128709
31MP0001661_extended_life_span1.33759584
32MP0003091_abnormal_cell_migration1.29176198
33MP0002998_abnormal_bone_remodeling1.23326634
34MP0003724_increased_susceptibility_to1.22080538
35MP0004134_abnormal_chest_morphology1.21291076
36MP0005171_absent_coat_pigmentation1.20180063
37MP0002877_abnormal_melanocyte_morpholog1.16187949
38MP0001299_abnormal_eye_distance/1.15502288
39MP0003941_abnormal_skin_development1.12407721
40MP0000163_abnormal_cartilage_morphology1.11498612
41MP0003385_abnormal_body_wall1.10485123
42MP0002115_abnormal_skeleton_extremities1.09571276
43MP0000749_muscle_degeneration1.09217632
44MP0001533_abnormal_skeleton_physiology1.09116766
45MP0000762_abnormal_tongue_morphology1.04139538
46MP0003191_abnormal_cellular_cholesterol1.03535026
47MP0005165_increased_susceptibility_to1.03262589
48MP0000767_abnormal_smooth_muscle1.01507982
49MP0005375_adipose_tissue_phenotype0.98838499
50MP0000003_abnormal_adipose_tissue0.98743578
51MP0005666_abnormal_adipose_tissue0.98417143
52MP0005595_abnormal_vascular_smooth0.95386939
53MP0004084_abnormal_cardiac_muscle0.94634751
54MP0002282_abnormal_trachea_morphology0.93648436
55MP0002837_dystrophic_cardiac_calcinosis0.93337824
56MP0003283_abnormal_digestive_organ0.91374608
57MP0001915_intracranial_hemorrhage0.89930449
58MP0000733_abnormal_muscle_development0.88274778
59MP0002113_abnormal_skeleton_development0.87929541
60MP0002168_other_aberrant_phenotype0.86742794
61MP0003795_abnormal_bone_structure0.86307653
62MP0001879_abnormal_lymphatic_vessel0.83799882
63MP0004858_abnormal_nervous_system0.83676113
64MP0005369_muscle_phenotype0.83551136
65MP0002932_abnormal_joint_morphology0.81855141
66MP0005197_abnormal_uvea_morphology0.81502291
67MP0001849_ear_inflammation0.81299256
68MP0000750_abnormal_muscle_regeneration0.79995346
69MP0000759_abnormal_skeletal_muscle0.79142642
70MP0005388_respiratory_system_phenotype0.78915749
71MP0002133_abnormal_respiratory_system0.78915749
72MP0006138_congestive_heart_failure0.76162164
73MP0002089_abnormal_postnatal_growth/wei0.75956103
74MP0003045_fibrosis0.74461550
75MP0008004_abnormal_stomach_pH0.73810294
76MP0005164_abnormal_response_to0.70844847
77MP0003828_pulmonary_edema0.69620531
78MP0002128_abnormal_blood_circulation0.67592387
79MP0000343_altered_response_to0.67554546
80MP0000249_abnormal_blood_vessel0.67494079
81MP0000858_altered_metastatic_potential0.66704785
82MP0005330_cardiomyopathy0.65811384
83MP0003115_abnormal_respiratory_system0.64172273
84MP0001177_atelectasis0.63091279
85MP0003868_abnormal_feces_composition0.62003966
86MP0004087_abnormal_muscle_fiber0.61865084
87MP0002925_abnormal_cardiovascular_devel0.60905989
88MP0010771_integument_phenotype0.60000427
89MP0000538_abnormal_urinary_bladder0.58986894
90MP0003252_abnormal_bile_duct0.58516748
91MP0009379_abnormal_foot_pigmentation0.58409326
92MP0003448_altered_tumor_morphology0.58033944
93MP0001175_abnormal_lung_morphology0.57103995
94MP0003942_abnormal_urinary_system0.56973681
95MP0002254_reproductive_system_inflammat0.55210508
96MP0000428_abnormal_craniofacial_morphol0.55147390
97MP0005076_abnormal_cell_differentiation0.54835051
98MP0000747_muscle_weakness0.54326089
99MP0010352_gastrointestinal_tract_polyps0.54139193
100MP0009115_abnormal_fat_cell0.53781270
101MP0001614_abnormal_blood_vessel0.52807904
102MP0002109_abnormal_limb_morphology0.52318134
103MP0003755_abnormal_palate_morphology0.51046788
104MP0004233_abnormal_muscle_weight0.49646068
105MP0008775_abnormal_heart_ventricle0.47658065
106MP0010386_abnormal_urinary_bladder0.46926183
107MP0000534_abnormal_ureter_morphology0.46617022
108MP0001348_abnormal_lacrimal_gland0.46461152
109MP0000432_abnormal_head_morphology0.46207743
110MP0005670_abnormal_white_adipose0.45503743
111MP0002116_abnormal_craniofacial_bone0.44715092
112MP0009053_abnormal_anal_canal0.44637075
113MP0002249_abnormal_larynx_morphology0.44204273
114MP0005620_abnormal_muscle_contractility0.43898849
115MP0005193_abnormal_anterior_eye0.43064513
116MP0004883_abnormal_blood_vessel0.42682543
117MP0005220_abnormal_exocrine_pancreas0.42237242
118MP0003195_calcinosis0.41153952
119MP0003300_gastrointestinal_ulcer0.40945905
120MP0000049_abnormal_middle_ear0.40781094

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)9.66560387
2Soft skin (HP:0000977)5.29404629
3Aortic dissection (HP:0002647)5.29071366
4Vertebral compression fractures (HP:0002953)4.64995196
5Peritonitis (HP:0002586)4.61984380
6Broad metatarsal (HP:0001783)4.60288320
7Aortic aneurysm (HP:0004942)4.50099990
8Biconcave vertebral bodies (HP:0004586)4.49795068
9Atrophic scars (HP:0001075)4.44591012
10Ankle contracture (HP:0006466)4.39390958
11Shallow orbits (HP:0000586)4.39143844
12Dilatation of the ascending aorta (HP:0005111)4.25123300
13Fragile skin (HP:0001030)4.24487071
14Bladder diverticulum (HP:0000015)4.19873731
15Abnormality of dentin (HP:0010299)4.12629154
16Neonatal short-limb short stature (HP:0008921)3.96099858
17Wormian bones (HP:0002645)3.92208418
18Type 1 muscle fiber predominance (HP:0003803)3.88396228
19Genu recurvatum (HP:0002816)3.87258208
20Spinal rigidity (HP:0003306)3.86818079
21Cerebral aneurysm (HP:0004944)3.86742758
22Follicular hyperkeratosis (HP:0007502)3.76388319
23Blue sclerae (HP:0000592)3.66103902
24Increased connective tissue (HP:0009025)3.60509457
25Abnormal delivery (HP:0001787)3.54367059
26Mitral valve prolapse (HP:0001634)3.33866919
27Cervical subluxation (HP:0003308)3.24007667
28Overgrowth (HP:0001548)3.18362531
29Mildly elevated creatine phosphokinase (HP:0008180)3.18088499
30Wrist flexion contracture (HP:0001239)3.17780729
31Hyperextensible skin (HP:0000974)3.08209337
32Round ear (HP:0100830)3.07601334
33Slender build (HP:0001533)3.05015479
34Abnormality of the acetabulum (HP:0003170)2.88822795
35Bowel diverticulosis (HP:0005222)2.73852824
36Vascular tortuosity (HP:0004948)2.64281679
37Infantile muscular hypotonia (HP:0008947)2.63393661
38Osteolytic defects of the phalanges of the hand (HP:0009771)2.62019219
39Osteolytic defects of the hand bones (HP:0009699)2.62019219
40Mitral regurgitation (HP:0001653)2.60665303
41Elbow flexion contracture (HP:0002987)2.58951862
42Breech presentation (HP:0001623)2.58747436
43Increased variability in muscle fiber diameter (HP:0003557)2.56367693
44Mitral stenosis (HP:0001718)2.56108811
45Ectopia lentis (HP:0001083)2.53710343
46Joint stiffness (HP:0001387)2.52206262
47Broad ribs (HP:0000885)2.48608198
48Spondylolisthesis (HP:0003302)2.47068889
49Osteoarthritis (HP:0002758)2.43330441
50Wide anterior fontanel (HP:0000260)2.42372902
51Coxa vara (HP:0002812)2.40562359
52Absent frontal sinuses (HP:0002688)2.39119086
53Beaking of vertebral bodies (HP:0004568)2.35101209
54Thin bony cortex (HP:0002753)2.33701880
55Joint laxity (HP:0001388)2.32917596
56Aneurysm (HP:0002617)2.27955982
57Abnormality of skeletal muscle fiber size (HP:0012084)2.25518245
58Short nail (HP:0001799)2.23016301
59Decreased skull ossification (HP:0004331)2.22576265
60Generalized amyotrophy (HP:0003700)2.20765906
61Bell-shaped thorax (HP:0001591)2.20620193
62Ovoid vertebral bodies (HP:0003300)2.20377836
63Venous abnormality (HP:0002624)2.19163268
64Decreased subcutaneous fat (HP:0001002)2.18340043
65Osteopenia (HP:0000938)2.14626209
66Camptodactyly of toe (HP:0001836)2.08956661
67Hypoplasia of the iris (HP:0007676)2.06798639
68Reduced subcutaneous adipose tissue (HP:0003758)2.06657294
69Abnormality of skull ossification (HP:0002703)2.06035923
70Nonimmune hydrops fetalis (HP:0001790)2.05597245
71Arterial tortuosity (HP:0005116)2.04090211
72Tibial bowing (HP:0002982)2.00908137
73Protrusio acetabuli (HP:0003179)10.2427707
74Achilles tendon contracture (HP:0001771)1.98684783
75Aortic regurgitation (HP:0001659)1.98194204
76Platyspondyly (HP:0000926)1.97871112
77Premature skin wrinkling (HP:0100678)1.97321148
78Mild short stature (HP:0003502)1.93599415
79Venous insufficiency (HP:0005293)1.93313587
80Thin skin (HP:0000963)1.92802888
81Difficulty climbing stairs (HP:0003551)1.92141449
82Femoral bowing (HP:0002980)1.91735129
83Ulnar bowing (HP:0003031)1.90910142
84Distal lower limb amyotrophy (HP:0008944)1.90108497
85Hypoventilation (HP:0002791)1.89477901
86Protruding ear (HP:0000411)1.88468259
87Aortic valve stenosis (HP:0001650)1.87232313
88Delayed cranial suture closure (HP:0000270)1.86566831
89Delayed closure of the anterior fontanelle (HP:0001476)1.86018288
90Striae distensae (HP:0001065)1.85814321
91Syringomyelia (HP:0003396)1.84592576
92Spinal cord lesions (HP:0100561)1.84592576
93Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.84126896
94Coronal craniosynostosis (HP:0004440)1.83321637
95Disproportionate tall stature (HP:0001519)1.81048391
96Knee flexion contracture (HP:0006380)1.81002710
97Increased corneal curvature (HP:0100692)1.80819255
98Keratoconus (HP:0000563)1.80819255
99Flared iliac wings (HP:0002869)1.80286697
100Deviation of the hallux (HP:0010051)1.80005949
101Redundant skin (HP:0001582)1.79872852
102Abnormality of the Achilles tendon (HP:0005109)1.79386078
103Myocardial infarction (HP:0001658)1.78733330
104Limited hip movement (HP:0008800)1.78619621
105Inguinal hernia (HP:0000023)1.78605212
106Cardiovascular calcification (HP:0011915)1.78524865
107Abnormality of the anterior chamber (HP:0000593)1.78429436
108Limb-girdle muscle weakness (HP:0003325)1.78130287
109Mesomelia (HP:0003027)1.77760265
110Distal lower limb muscle weakness (HP:0009053)1.77619411
111Scapular winging (HP:0003691)1.77236597
112Metaphyseal dysplasia (HP:0100255)1.76325819
113Abnormality of the peritoneum (HP:0002585)1.76210456
114Natal tooth (HP:0000695)1.74323880
115Persistence of primary teeth (HP:0006335)1.72941973
116Hallux valgus (HP:0001822)1.71534342
117Congenital glaucoma (HP:0001087)1.71283287
118Cupped ribs (HP:0000887)1.70684399
119Spinal cord compression (HP:0002176)1.70132833
120Flat cornea (HP:0007720)1.68307917
121Pulmonary artery stenosis (HP:0004415)1.67985575
122Abnormality of carpal bone ossification (HP:0006257)1.67644947

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR25.79177133
2PDGFRA4.07096770
3TIE13.92864009
4TRIB33.60698826
5LATS23.48688521
6TTN3.12136754
7EPHA32.90685987
8ERN12.88607236
9FER2.78369414
10SIK12.76033568
11NEK92.58038652
12MYLK2.12465403
13PLK22.10093541
14MUSK1.92633391
15ERBB31.89479352
16EPHA21.88837345
17PTK2B1.78388198
18PIM21.78118269
19STK38L1.73811966
20TGFBR21.70829357
21TRPM71.69736293
22PKN21.69627260
23PAK21.69533168
24MOS1.68624152
25PIK3CA1.59358869
26MAP3K121.53931719
27LATS11.47814834
28BMX1.45242680
29LMTK21.39631716
30TESK11.38542250
31LIMK11.36792551
32PIK3CG1.36573961
33STK381.33937690
34IRAK31.33281186
35DMPK1.30319683
36TGFBR11.29443401
37EPHB21.28424041
38NME21.24177321
39PAK31.17420806
40ROCK11.16182131
41FRK1.13660132
42ACVR1B1.08165359
43CLK11.06333725
44PAK41.04819012
45PTK21.04744032
46PDGFRB1.03893548
47STK31.03103841
48MAP2K11.01657505
49PRKD21.01094075
50EIF2AK11.00659329
51ILK0.98861647
52PRKG20.93937067
53DAPK30.90814355
54ARAF0.88719320
55MET0.84801633
56MAPKAPK30.84288952
57AKT30.83463789
58FGFR40.82419490
59RIPK10.79972409
60PAK60.79619412
61ADRBK10.79580404
62MAP3K60.79420858
63PRKCH0.78958213
64EPHB10.78118701
65JAK10.77967054
66LRRK20.77164908
67STK240.74485653
68ABL20.74334446
69BCKDK0.72986858
70GRK50.72502535
71NTRK10.71911085
72GSK3A0.69737737
73ROCK20.64321247
74FLT30.63852838
75FGFR10.63806889
76KDR0.62495750
77IRAK10.60749334
78CDC42BPA0.60725264
79EIF2AK30.60572202
80DYRK1B0.60138479
81CDK140.60119349
82BMPR1B0.60080359
83MAPK70.57488143
84TYK20.57044508
85PDK30.56584220
86PDK40.56584220
87PRKD10.56274437
88CDK80.56023517
89PDK20.51970014
90PRKCE0.51361866
91STK100.50253965
92JAK30.49429230
93INSR0.49197827
94RPS6KA20.48616200
95CDK150.48243760
96RPS6KA40.47544161
97PAK10.47079398
98RET0.46692263
99MTOR0.45251543
100ZAP700.44991000
101MAP3K30.43526729
102GRK10.43120538
103CDK180.42637233
104PTK60.42272205
105CDK60.40250117
106MST1R0.39981721
107PRKD30.39863598
108FGFR30.39094650
109MAPKAPK50.39010544
110MAP3K130.38519819
111CDK11A0.37990456
112ZAK0.37036962
113ERBB40.36507263
114MELK0.36502425
115KIT0.34818339
116SRC0.34712809
117CDK90.33049428
118IGF1R0.32924803
119PRKAA20.31698574
120BUB10.30475959
121CAMK1D0.30058905
122MAPKAPK20.29387046
123FES0.28892069
124TESK20.28637894
125INSRR0.28592323
126TAOK20.26833168
127STK390.26767346
128CSK0.25708007
129BMPR20.23851467
130CAMKK20.21505469
131ABL10.21178280
132ICK0.21071628
133CAMK2D0.20575625
134CAMK2G0.20074043

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045125.20599664
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005324.09637331
3Focal adhesion_Homo sapiens_hsa045103.25876147
4Protein digestion and absorption_Homo sapiens_hsa049743.22210215
5Malaria_Homo sapiens_hsa051442.99192739
6Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.68753521
7Dilated cardiomyopathy_Homo sapiens_hsa054142.57221581
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.26879507
9AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.23574484
10Proteoglycans in cancer_Homo sapiens_hsa052052.13350885
11Amoebiasis_Homo sapiens_hsa051462.09521840
12TGF-beta signaling pathway_Homo sapiens_hsa043502.07290197
13Bladder cancer_Homo sapiens_hsa052191.85113076
14PI3K-Akt signaling pathway_Homo sapiens_hsa041511.82642303
15Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.68762018
16Melanoma_Homo sapiens_hsa052181.63211213
17Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.61443179
18Adherens junction_Homo sapiens_hsa045201.59758036
19Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.33096696
20MicroRNAs in cancer_Homo sapiens_hsa052061.21851443
21Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.19243915
22Viral myocarditis_Homo sapiens_hsa054161.17570789
23Hippo signaling pathway_Homo sapiens_hsa043901.17361559
24Regulation of actin cytoskeleton_Homo sapiens_hsa048101.16504602
25Other glycan degradation_Homo sapiens_hsa005111.13199502
26Phagosome_Homo sapiens_hsa041451.12908151
27Sulfur metabolism_Homo sapiens_hsa009201.12865455
28Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.12170313
29Starch and sucrose metabolism_Homo sapiens_hsa005001.11602776
30Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.08383489
31Chronic myeloid leukemia_Homo sapiens_hsa052201.03603354
32Glioma_Homo sapiens_hsa052141.01471159
33Platelet activation_Homo sapiens_hsa046110.94957440
34Prostate cancer_Homo sapiens_hsa052150.92512047
35Small cell lung cancer_Homo sapiens_hsa052220.92487805
36PPAR signaling pathway_Homo sapiens_hsa033200.89868837
37TNF signaling pathway_Homo sapiens_hsa046680.88652245
38Vibrio cholerae infection_Homo sapiens_hsa051100.86615226
39Mineral absorption_Homo sapiens_hsa049780.85411725
40HIF-1 signaling pathway_Homo sapiens_hsa040660.84959769
41Arachidonic acid metabolism_Homo sapiens_hsa005900.81053745
42Leukocyte transendothelial migration_Homo sapiens_hsa046700.80484836
43Pancreatic cancer_Homo sapiens_hsa052120.77422108
44Rap1 signaling pathway_Homo sapiens_hsa040150.77060180
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.75947581
46Glycerolipid metabolism_Homo sapiens_hsa005610.75860982
47Complement and coagulation cascades_Homo sapiens_hsa046100.75112274
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.74008373
49Shigellosis_Homo sapiens_hsa051310.73716342
50Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73448295
51Basal cell carcinoma_Homo sapiens_hsa052170.72922020
52Thyroid hormone synthesis_Homo sapiens_hsa049180.72863161
53Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72772546
54Central carbon metabolism in cancer_Homo sapiens_hsa052300.72442723
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72362482
56Galactose metabolism_Homo sapiens_hsa000520.71821610
57Pathways in cancer_Homo sapiens_hsa052000.71384269
58Wnt signaling pathway_Homo sapiens_hsa043100.71046393
59Adipocytokine signaling pathway_Homo sapiens_hsa049200.69924800
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69794024
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67705585
62Rheumatoid arthritis_Homo sapiens_hsa053230.67471708
63Gap junction_Homo sapiens_hsa045400.67200899
64Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.66510842
65Hedgehog signaling pathway_Homo sapiens_hsa043400.65869538
66Tight junction_Homo sapiens_hsa045300.65227197
67Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63900677
68Toxoplasmosis_Homo sapiens_hsa051450.61694415
69p53 signaling pathway_Homo sapiens_hsa041150.61183124
70AMPK signaling pathway_Homo sapiens_hsa041520.59155874
71Circadian rhythm_Homo sapiens_hsa047100.59083697
72Caffeine metabolism_Homo sapiens_hsa002320.58990881
73Insulin resistance_Homo sapiens_hsa049310.58513747
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.57543264
75Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56865733
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52198574
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50035902
78Ras signaling pathway_Homo sapiens_hsa040140.49685860
79Arginine and proline metabolism_Homo sapiens_hsa003300.49395439
80Glutathione metabolism_Homo sapiens_hsa004800.49015924
81Renin-angiotensin system_Homo sapiens_hsa046140.48711928
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48494319
83Salmonella infection_Homo sapiens_hsa051320.48012244
84HTLV-I infection_Homo sapiens_hsa051660.47894281
85Melanogenesis_Homo sapiens_hsa049160.47549032
86Sphingolipid metabolism_Homo sapiens_hsa006000.47098497
87Apoptosis_Homo sapiens_hsa042100.46877545
88Prion diseases_Homo sapiens_hsa050200.46092945
89Endocytosis_Homo sapiens_hsa041440.44972163
90Hepatitis B_Homo sapiens_hsa051610.43142634
91Insulin signaling pathway_Homo sapiens_hsa049100.42530662
92Lysine degradation_Homo sapiens_hsa003100.41337857
93Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.40946989
94Pentose phosphate pathway_Homo sapiens_hsa000300.40934622
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40709538
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40645419
97FoxO signaling pathway_Homo sapiens_hsa040680.40293151
98African trypanosomiasis_Homo sapiens_hsa051430.40276009
99Osteoclast differentiation_Homo sapiens_hsa043800.40275974
100Fatty acid degradation_Homo sapiens_hsa000710.39652473
101Ovarian steroidogenesis_Homo sapiens_hsa049130.39389975
102Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.39110353
103Chemical carcinogenesis_Homo sapiens_hsa052040.39099059
1042-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.38792915
105Estrogen signaling pathway_Homo sapiens_hsa049150.38781463
106Cyanoamino acid metabolism_Homo sapiens_hsa004600.38389781
107Glycosaminoglycan degradation_Homo sapiens_hsa005310.38326168
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37945564
109Tyrosine metabolism_Homo sapiens_hsa003500.37920674
110Phenylalanine metabolism_Homo sapiens_hsa003600.37179526
111N-Glycan biosynthesis_Homo sapiens_hsa005100.36978935
112Phospholipase D signaling pathway_Homo sapiens_hsa040720.35671439
113Lysosome_Homo sapiens_hsa041420.34402120
114Thyroid cancer_Homo sapiens_hsa052160.34232552
115Renal cell carcinoma_Homo sapiens_hsa052110.33761242
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32553528
117Histidine metabolism_Homo sapiens_hsa003400.32373666
118GnRH signaling pathway_Homo sapiens_hsa049120.31647947
119Fatty acid biosynthesis_Homo sapiens_hsa000610.31325170
120Axon guidance_Homo sapiens_hsa043600.30854826
121Tuberculosis_Homo sapiens_hsa051520.30610515
122Dorso-ventral axis formation_Homo sapiens_hsa043200.30324301
123Steroid hormone biosynthesis_Homo sapiens_hsa001400.29798362
124Renin secretion_Homo sapiens_hsa049240.29222539
125Protein export_Homo sapiens_hsa030600.29080767
126Pertussis_Homo sapiens_hsa051330.28755099

Most similar genes based on co-expression Upload to Enrichr

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