SRP9P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine catabolic process (GO:0006216)5.33187262
2cytidine deamination (GO:0009972)5.33187262
3cytidine metabolic process (GO:0046087)5.33187262
4DNA deamination (GO:0045006)5.33028484
5deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.81983653
6pyrimidine ribonucleoside catabolic process (GO:0046133)4.60305920
7regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.49554719
8purine deoxyribonucleotide catabolic process (GO:0009155)4.44039951
9Arp2/3 complex-mediated actin nucleation (GO:0034314)4.15446310
10positive regulation of B cell differentiation (GO:0045579)4.10091869
11RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.00253361
12tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.00253361
13deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.95350744
14mature B cell differentiation involved in immune response (GO:0002313)3.90168286
15negative regulation of B cell apoptotic process (GO:0002903)3.86981967
16deoxyribose phosphate catabolic process (GO:0046386)3.86854456
17positive thymic T cell selection (GO:0045059)3.82894957
18deoxyribonucleotide catabolic process (GO:0009264)3.78683081
19Peyers patch development (GO:0048541)3.61808182
20mucosal-associated lymphoid tissue development (GO:0048537)3.61808182
21positive T cell selection (GO:0043368)3.55726899
22sequestering of actin monomers (GO:0042989)3.55726387
23purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.50223943
24actin nucleation (GO:0045010)3.49010666
25pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.47254782
26positive regulation of interleukin-8 secretion (GO:2000484)3.46269999
27purine deoxyribonucleotide metabolic process (GO:0009151)3.45515074
28establishment of integrated proviral latency (GO:0075713)3.43858295
29mature B cell differentiation (GO:0002335)3.43563383
30immunoglobulin mediated immune response (GO:0016064)3.43050039
31regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.40326414
32B cell mediated immunity (GO:0019724)3.40176675
33negative T cell selection (GO:0043383)3.38030838
34purine nucleotide salvage (GO:0032261)3.37805190
35DNA ligation (GO:0006266)3.32348141
36regulation of B cell differentiation (GO:0045577)3.24277246
37establishment of viral latency (GO:0019043)3.19460393
38DNA strand elongation involved in DNA replication (GO:0006271)3.17674592
392-deoxyribonucleotide metabolic process (GO:0009394)3.13021145
40deoxyribose phosphate metabolic process (GO:0019692)3.11401614
41iron-sulfur cluster assembly (GO:0016226)3.10657252
42metallo-sulfur cluster assembly (GO:0031163)3.10657252
43DNA strand elongation (GO:0022616)3.07490953
44telomere maintenance via semi-conservative replication (GO:0032201)3.07346805
45autophagic vacuole fusion (GO:0000046)3.06991590
46purine nucleobase biosynthetic process (GO:0009113)3.05612664
47negative thymic T cell selection (GO:0045060)3.01987639
48positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.99515507
49ribosomal small subunit assembly (GO:0000028)2.95962833
50negative regulation of T cell apoptotic process (GO:0070233)2.92351631
51DNA dealkylation (GO:0035510)2.91319089
52deoxyribonucleotide metabolic process (GO:0009262)2.89367763
53DNA replication-dependent nucleosome assembly (GO:0006335)2.87941410
54DNA replication-dependent nucleosome organization (GO:0034723)2.87941410
55mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.87016575
56pyrimidine nucleotide catabolic process (GO:0006244)2.86934678
57nucleobase biosynthetic process (GO:0046112)2.86763541
58negative regulation by host of viral transcription (GO:0043922)2.86047303
59negative regulation of lymphocyte apoptotic process (GO:0070229)2.85051545
60DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.82519240
61response to interferon-beta (GO:0035456)2.81543172
62telomere maintenance via recombination (GO:0000722)2.81542289
63chaperone mediated protein folding requiring cofactor (GO:0051085)2.80271100
64regulation of cellular amino acid metabolic process (GO:0006521)2.79914681
65positive regulation of antigen processing and presentation (GO:0002579)2.79611273
66intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.79323466
67signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.79323466
68positive regulation of gamma-delta T cell activation (GO:0046645)2.79052012
69base-excision repair, AP site formation (GO:0006285)2.78321515
70antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.78230860
71signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.77545380
72signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.77545380
73signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.77545380
74negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.74854088
75positive regulation of uterine smooth muscle contraction (GO:0070474)2.74466638
76viral mRNA export from host cell nucleus (GO:0046784)2.74159727
77positive regulation of calcium-mediated signaling (GO:0050850)2.73641074
78aggressive behavior (GO:0002118)2.73158914
79pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.73028616
80DNA demethylation (GO:0080111)2.72407133
81deoxyribonucleotide biosynthetic process (GO:0009263)2.70778119
82positive regulation of monocyte chemotaxis (GO:0090026)2.70632335
83deoxyribose phosphate biosynthetic process (GO:0046385)2.70123543
842-deoxyribonucleotide biosynthetic process (GO:0009265)2.70123543
85mismatch repair (GO:0006298)2.67464697
86mitotic recombination (GO:0006312)2.67065074
87signal transduction involved in DNA integrity checkpoint (GO:0072401)2.65803205
88signal transduction involved in DNA damage checkpoint (GO:0072422)2.65803205
89positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.65609234
90antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.64320702
91ATP synthesis coupled proton transport (GO:0015986)2.63958376
92energy coupled proton transport, down electrochemical gradient (GO:0015985)2.63958376
93regulation of interleukin-8 secretion (GO:2000482)2.63221006
94regulation of RIG-I signaling pathway (GO:0039535)2.62914010
95signal transduction involved in cell cycle checkpoint (GO:0072395)2.61474687
96purine-containing compound salvage (GO:0043101)2.60113991
97regulation of B cell receptor signaling pathway (GO:0050855)2.56576873
98regulation of antigen processing and presentation (GO:0002577)2.54793559
99pseudouridine synthesis (GO:0001522)2.54463807
100cellular response to interferon-beta (GO:0035458)2.54325714

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.56275706
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.57424041
3ELF1_17652178_ChIP-ChIP_JURKAT_Human3.92846891
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.57844815
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.14226781
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.12364559
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.06307460
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.02452443
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.99235612
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.90108215
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.88292663
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.77308889
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.74629478
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.68782735
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.68408508
16VDR_23849224_ChIP-Seq_CD4+_Human2.50363192
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.44365812
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.43161204
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.40461604
20FOXP3_21729870_ChIP-Seq_TREG_Human2.36946578
21CIITA_25753668_ChIP-Seq_RAJI_Human2.30451654
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.25498394
23MYC_18358816_ChIP-ChIP_MESCs_Mouse2.23978077
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.19917028
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.17879534
26CREB1_15753290_ChIP-ChIP_HEK293T_Human2.13230764
27IRF8_21731497_ChIP-ChIP_J774_Mouse2.02484738
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.02323865
29SRF_21415370_ChIP-Seq_HL-1_Mouse2.00404956
30FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.96967905
31MYB_26560356_Chip-Seq_TH2_Human1.95241379
32HOXB4_20404135_ChIP-ChIP_EML_Mouse1.91816435
33TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.90945250
34ELK1_19687146_ChIP-ChIP_HELA_Human1.89816286
35STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.89632910
36MYC_19030024_ChIP-ChIP_MESCs_Mouse1.87940660
37HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.71006845
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.70578466
39SPI1_23547873_ChIP-Seq_NB4_Human1.70141771
40SCL_19346495_ChIP-Seq_HPC-7_Human1.66893883
41STAT4_19710469_ChIP-ChIP_TH1__Mouse1.65417612
42PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.60554843
43RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.60204439
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.57222544
45FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.51518996
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49274026
47UTX_26944678_Chip-Seq_JUKART_Human1.48913367
48NELFA_20434984_ChIP-Seq_ESCs_Mouse1.47147947
49MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.46761547
50DCP1A_22483619_ChIP-Seq_HELA_Human1.45463725
51FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.43269093
52XRN2_22483619_ChIP-Seq_HELA_Human1.41012529
53ERG_20887958_ChIP-Seq_HPC-7_Mouse1.40646748
54MYB_26560356_Chip-Seq_TH1_Human1.39851068
55GABP_19822575_ChIP-Seq_HepG2_Human1.35433804
56E2F1_18555785_ChIP-Seq_MESCs_Mouse1.34964667
57GATA3_27048872_Chip-Seq_THYMUS_Human1.33549962
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.31667781
59PADI4_21655091_ChIP-ChIP_MCF-7_Human1.31447343
60TTF2_22483619_ChIP-Seq_HELA_Human1.30214889
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.29397268
62CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.27889069
63MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.27165886
64FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.27054904
65MYC_19079543_ChIP-ChIP_MESCs_Mouse1.26818381
66MYC_22102868_ChIP-Seq_BL_Human1.22738381
67MYC_18940864_ChIP-ChIP_HL60_Human1.19254478
68YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18343050
69GATA3_26560356_Chip-Seq_TH2_Human1.17388407
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16747777
71ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15268744
72CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.14431802
73LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.12978813
74PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11399767
75POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.11275792
76E2F1_21310950_ChIP-Seq_MCF-7_Human1.09392679
77GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.08335388
78MAF_26560356_Chip-Seq_TH1_Human1.06115989
79MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.03583687
80IRF1_19129219_ChIP-ChIP_H3396_Human1.02781227
81POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.02348094
82MAF_26560356_Chip-Seq_TH2_Human1.02128660
83CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.01835781
84FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01538828
85RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.01481037
86BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00475026
87BCL6_27268052_Chip-Seq_Bcells_Human0.99858621
88CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.94655024
89MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.94425646
90CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.93389168
91ZNF274_21170338_ChIP-Seq_K562_Hela0.93141288
92ELF1_20517297_ChIP-Seq_JURKAT_Human0.92928877
93LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.92062451
94RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.90409742
95P300_27268052_Chip-Seq_Bcells_Human0.89256643
96KDM5A_27292631_Chip-Seq_BREAST_Human0.87901275
97E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.84419436
98FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.83988191
99RUNX_20019798_ChIP-Seq_JUKART_Human0.83599588
100GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.83531771

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.09200309
2MP0001835_abnormal_antigen_presentation3.90841926
3MP0010094_abnormal_chromosome_stability2.87717241
4MP0009697_abnormal_copulation2.84449739
5MP0008058_abnormal_DNA_repair2.55629394
6MP0003763_abnormal_thymus_physiology2.50126907
7MP0001800_abnormal_humoral_immune2.49858551
8MP0009333_abnormal_splenocyte_physiolog2.46512399
9MP0005075_abnormal_melanosome_morpholog2.44478820
10MP0003806_abnormal_nucleotide_metabolis2.39533401
11MP0002148_abnormal_hypersensitivity_rea2.37979514
12MP0009785_altered_susceptibility_to2.35628673
13MP0005000_abnormal_immune_tolerance2.34412678
14MP0002396_abnormal_hematopoietic_system2.27072309
15MP0000372_irregular_coat_pigmentation2.23315300
16MP0002166_altered_tumor_susceptibility2.22165781
17MP0002420_abnormal_adaptive_immunity2.13903787
18MP0002398_abnormal_bone_marrow2.12259427
19MP0009379_abnormal_foot_pigmentation2.10405101
20MP0001819_abnormal_immune_cell2.05998144
21MP0002006_tumorigenesis2.02937570
22MP0002452_abnormal_antigen_presenting2.02021143
23MP0002723_abnormal_immune_serum2.01131005
24MP0005645_abnormal_hypothalamus_physiol1.96656729
25MP0003786_premature_aging1.90679693
26MP0001873_stomach_inflammation1.88446815
27MP0001790_abnormal_immune_system1.86068800
28MP0005387_immune_system_phenotype1.86068800
29MP0005025_abnormal_response_to1.83226436
30MP0004147_increased_porphyrin_level1.82136117
31MP0000716_abnormal_immune_system1.81770462
32MP0000689_abnormal_spleen_morphology1.80536924
33MP0000465_gastrointestinal_hemorrhage1.75577529
34MP0005397_hematopoietic_system_phenotyp1.75521204
35MP0001545_abnormal_hematopoietic_system1.75521204
36MP0003866_abnormal_defecation1.72384942
37MP0001853_heart_inflammation1.72042747
38MP0002722_abnormal_immune_system1.70620494
39MP0002163_abnormal_gland_morphology1.69819326
40MP0000685_abnormal_immune_system1.69515008
41MP0002234_abnormal_pharynx_morphology1.68344789
42MP0002429_abnormal_blood_cell1.62048613
43MP0002019_abnormal_tumor_incidence1.61310181
44MP0003111_abnormal_nucleus_morphology1.60621476
45MP0002653_abnormal_ependyma_morphology1.57824569
46MP0004957_abnormal_blastocyst_morpholog1.54414984
47MP0005174_abnormal_tail_pigmentation1.52300222
48MP0003693_abnormal_embryo_hatching1.51614233
49MP0006036_abnormal_mitochondrial_physio1.51287969
50MP0005464_abnormal_platelet_physiology1.45380115
51MP0003646_muscle_fatigue1.42088759
52MP0000703_abnormal_thymus_morphology1.38716745
53MP0008057_abnormal_DNA_replication1.38494906
54MP0003183_abnormal_peptide_metabolism1.38070391
55MP0000015_abnormal_ear_pigmentation1.36831233
56MP0009764_decreased_sensitivity_to1.33204411
57MP0008007_abnormal_cellular_replicative1.32099915
58MP0002405_respiratory_system_inflammati1.29718575
59MP0006082_CNS_inflammation1.29508365
60MP0008961_abnormal_basal_metabolism1.25957946
61MP0006072_abnormal_retinal_apoptosis1.25683960
62MP0003077_abnormal_cell_cycle1.24039837
63MP0002419_abnormal_innate_immunity1.22636772
64MP0001188_hyperpigmentation1.21559715
65MP0008872_abnormal_physiological_respon1.14524517
66MP0009278_abnormal_bone_marrow1.10925453
67MP0006292_abnormal_olfactory_placode1.08838342
68MP0008469_abnormal_protein_level1.08308061
69MP0005367_renal/urinary_system_phenotyp1.08257836
70MP0000516_abnormal_urinary_system1.08257836
71MP0002095_abnormal_skin_pigmentation1.03988029
72MP0001845_abnormal_inflammatory_respons1.03259156
73MP0003448_altered_tumor_morphology1.02279746
74MP0008995_early_reproductive_senescence1.01125110
75MP0009763_increased_sensitivity_to0.99634507
76MP0010307_abnormal_tumor_latency0.99473910
77MP0006035_abnormal_mitochondrial_morpho0.99351132
78MP0005084_abnormal_gallbladder_morpholo0.92714622
79MP0010155_abnormal_intestine_physiology0.92047326
80MP0002876_abnormal_thyroid_physiology0.91962138
81MP0004381_abnormal_hair_follicle0.89681397
82MP0004145_abnormal_muscle_electrophysio0.89543846
83MP0003186_abnormal_redox_activity0.88949397
84MP0005410_abnormal_fertilization0.86932595
85MP0000490_abnormal_crypts_of0.83971889
86MP0003075_altered_response_to0.83222441
87MP0005310_abnormal_salivary_gland0.83050450
88MP0000313_abnormal_cell_death0.77268835
89MP0003045_fibrosis0.76941066
90MP0003656_abnormal_erythrocyte_physiolo0.76427674
91MP0000613_abnormal_salivary_gland0.72234791
92MP0002138_abnormal_hepatobiliary_system0.71985240
93MP0008932_abnormal_embryonic_tissue0.70330393
94MP0000358_abnormal_cell_content/0.70121873
95MP0005379_endocrine/exocrine_gland_phen0.69326492
96MP0008873_increased_physiological_sensi0.68404264
97MP0005266_abnormal_metabolism0.68128590
98MP0001119_abnormal_female_reproductive0.67093827
99MP0009765_abnormal_xenobiotic_induced0.64291273
100MP0004808_abnormal_hematopoietic_stem0.64161394

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of B cell number (HP:0010975)5.17477648
2Autoimmune hemolytic anemia (HP:0001890)5.08967147
3Severe combined immunodeficiency (HP:0004430)5.00650823
4Aplastic anemia (HP:0001915)4.86556902
5B lymphocytopenia (HP:0010976)4.67967317
63-Methylglutaconic aciduria (HP:0003535)4.60774139
7Agammaglobulinemia (HP:0004432)4.27927884
8Combined immunodeficiency (HP:0005387)4.18364946
9Hypoproteinemia (HP:0003075)3.67671785
10Hepatocellular necrosis (HP:0001404)3.47931302
11Abnormality of the prostate (HP:0008775)3.35610330
12Abnormal mitochondria in muscle tissue (HP:0008316)3.33392421
13Acute necrotizing encephalopathy (HP:0006965)3.28816356
14Acute encephalopathy (HP:0006846)3.24932621
15Mitochondrial inheritance (HP:0001427)3.24904074
16Abnormality of T cell number (HP:0011839)3.23300858
17Autoimmune thrombocytopenia (HP:0001973)3.20889156
18Hepatic necrosis (HP:0002605)3.19833929
19Elevated erythrocyte sedimentation rate (HP:0003565)3.14611693
20Thyroiditis (HP:0100646)3.14060570
21IgG deficiency (HP:0004315)3.10851365
22Increased IgM level (HP:0003496)3.10543197
23Panhypogammaglobulinemia (HP:0003139)3.05171604
24Granulocytopenia (HP:0001913)3.03275890
25Pancytopenia (HP:0001876)3.01972263
26Eosinophilia (HP:0001880)2.91133086
27T lymphocytopenia (HP:0005403)2.88149671
28Abnormality of T cells (HP:0002843)2.85854545
29Increased intramyocellular lipid droplets (HP:0012240)2.85354654
30Recurrent viral infections (HP:0004429)2.85062839
31Meningitis (HP:0001287)2.83842164
32Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.78987187
33Decreased activity of mitochondrial respiratory chain (HP:0008972)2.78987187
34Abnormality of eosinophils (HP:0001879)2.76452383
35Type I transferrin isoform profile (HP:0003642)2.75027063
36Obstructive lung disease (HP:0006536)2.73699818
37Chronic obstructive pulmonary disease (HP:0006510)2.73699818
38Increased muscle lipid content (HP:0009058)2.69457835
39Increased CSF lactate (HP:0002490)2.65201397
40Abnormal delayed hypersensitivity skin test (HP:0002963)2.60598357
41Colon cancer (HP:0003003)2.59108873
42Renal cortical cysts (HP:0000803)2.58770743
43IgM deficiency (HP:0002850)2.57553811
44Oral leukoplakia (HP:0002745)2.53853479
45Progressive macrocephaly (HP:0004481)2.52447159
46Cerebral edema (HP:0002181)2.49234495
47Recurrent fungal infections (HP:0002841)2.47845684
48Abnormality of T cell physiology (HP:0011840)2.40461781
49Abnormality of the heme biosynthetic pathway (HP:0010472)2.36993377
50Dicarboxylic aciduria (HP:0003215)2.36584314
51Abnormality of dicarboxylic acid metabolism (HP:0010995)2.36584314
52Lipid accumulation in hepatocytes (HP:0006561)2.36170001
53Microvesicular hepatic steatosis (HP:0001414)2.32873628
54Pulmonary fibrosis (HP:0002206)2.28635225
55Lactic acidosis (HP:0003128)2.22972583
56Recurrent bronchitis (HP:0002837)2.22146223
57Amaurosis fugax (HP:0100576)2.18762773
58Abnormality of male internal genitalia (HP:0000022)2.16317589
59Encephalitis (HP:0002383)2.14477661
60Lymphoma (HP:0002665)2.12597983
61Chest pain (HP:0100749)2.12441834
62Amyotrophic lateral sclerosis (HP:0007354)2.11839999
63Rhabdomyolysis (HP:0003201)2.07768316
64Leukocytosis (HP:0001974)2.06614553
65Cerebral palsy (HP:0100021)2.05764255
66Increased hepatocellular lipid droplets (HP:0006565)2.03187064
67Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.02443964
68Abnormal protein N-linked glycosylation (HP:0012347)2.02443964
69Abnormal protein glycosylation (HP:0012346)2.02443964
70Abnormal glycosylation (HP:0012345)2.02443964
71Aplasia/Hypoplasia of the thymus (HP:0010515)2.01640845
72Decreased electroretinogram (ERG) amplitude (HP:0000654)2.01445251
73Mediastinal lymphadenopathy (HP:0100721)2.01244278
74Skin rash (HP:0000988)2.01114996
75Chronic mucocutaneous candidiasis (HP:0002728)2.00889065
76Recurrent cutaneous fungal infections (HP:0011370)2.00889065
77Hypertensive crisis (HP:0100735)1.97858775
78Hypergammaglobulinemia (HP:0010702)1.97238646
79Thrombocytosis (HP:0001894)1.96767039
80Stomatitis (HP:0010280)1.96338394
81Spastic paraparesis (HP:0002313)1.95641245
82Exercise intolerance (HP:0003546)1.90012475
83Aplasia/Hypoplasia of the uvula (HP:0010293)1.89771017
84Chronic diarrhea (HP:0002028)1.88002934
85Abnormality of the preputium (HP:0100587)1.85924599
86Bone marrow hypocellularity (HP:0005528)1.85347493
87Respiratory failure (HP:0002878)1.83506277
88Myelodysplasia (HP:0002863)1.82613936
89Petechiae (HP:0000967)1.82385470
90Abnormality of the renal cortex (HP:0011035)1.82240162
91Pulmonary infiltrates (HP:0002113)1.81839350
92Abnormality of cells of the lymphoid lineage (HP:0012140)1.81475162
93Severe visual impairment (HP:0001141)1.79709749
94Congenital stationary night blindness (HP:0007642)1.79628960
95Increased serum lactate (HP:0002151)1.78934412
96Absent rod-and cone-mediated responses on ERG (HP:0007688)1.78209730
97Ureteral stenosis (HP:0000071)1.77685626
98Cellular immunodeficiency (HP:0005374)1.75966771
99Hypoplasia of the thymus (HP:0000778)1.73682557
100Neutropenia (HP:0001875)1.72822739

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR5.57464940
2VRK24.68615331
3TESK23.55365567
4SCYL23.55104207
5MAP4K22.97859341
6TXK2.86076161
7BCKDK2.73606270
8NUAK12.45251482
9VRK12.12815053
10KIT2.12739064
11CDC72.08535996
12ZAK2.04955683
13PIM22.01260509
14FES1.96814653
15FLT31.59619791
16NME21.52219664
17ITK1.49544642
18PINK11.48717682
19MAP3K121.48279137
20MST41.44152685
21EIF2AK31.35612699
22MAP3K111.32666286
23NEK11.31983487
24MAP4K11.28417007
25TLK11.21237644
26TAOK31.20371477
27CCNB11.18892552
28SYK1.18842360
29TESK11.16180854
30DAPK11.11981638
31ATR1.11827793
32TEC1.09416308
33SRPK11.03873863
34BTK1.02922511
35GRK60.98385264
36JAK30.97350119
37TAOK20.96676661
38BUB10.96453570
39PIK3CG0.96044304
40IKBKB0.93837974
41CSF1R0.90790050
42AURKA0.89553667
43WEE10.88408011
44CDK80.87552179
45CSNK1G30.86235459
46PLK40.83139501
47BMPR20.82590145
48GRK70.82285877
49ADRBK20.81751472
50CDK190.80702603
51CSNK1G10.79649474
52EIF2AK10.79301252
53AURKB0.79127732
54LYN0.78573344
55EIF2AK20.76769437
56RPS6KA50.76297810
57MAPK130.76090814
58CHEK20.75211720
59ARAF0.73823489
60DAPK30.72549928
61MAP3K100.70705009
62LCK0.69516537
63CDK40.69449522
64MATK0.68716776
65PASK0.68584147
66CDK70.67504287
67CSNK1A1L0.63451489
68RPS6KA40.61590159
69PRKCQ0.61215707
70INSRR0.60954517
71TBK10.59199156
72PIM10.57808235
73PKN10.57785031
74OBSCN0.56841041
75PBK0.54031294
76RPS6KB20.53809500
77CSNK2A20.49992104
78TAF10.49815588
79NEK20.47524322
80CSNK1G20.46954384
81IKBKE0.46934307
82LIMK10.45863799
83MYLK0.45059149
84MAPKAPK30.44669742
85PAK10.43239382
86ATM0.42208083
87CLK10.41331462
88CSNK1A10.39487478
89CSNK2A10.39439716
90STK30.39277502
91MAPK110.38561346
92ILK0.37300543
93HCK0.36158996
94GRK10.34714708
95PLK10.33945477
96IGF1R0.33475788
97TIE10.32826389
98MAPKAPK50.32427417
99BLK0.31459600
100BMPR1B0.31121499

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.92726366
2Proteasome_Homo sapiens_hsa030503.57117729
3Graft-versus-host disease_Homo sapiens_hsa053323.55846314
4Autoimmune thyroid disease_Homo sapiens_hsa053203.27965928
5Allograft rejection_Homo sapiens_hsa053303.25745911
6Asthma_Homo sapiens_hsa053103.21554939
7DNA replication_Homo sapiens_hsa030303.19602086
8Antigen processing and presentation_Homo sapiens_hsa046122.88864397
9Non-homologous end-joining_Homo sapiens_hsa034502.66248236
10Mismatch repair_Homo sapiens_hsa034302.64606707
11Type I diabetes mellitus_Homo sapiens_hsa049402.61813937
12Homologous recombination_Homo sapiens_hsa034402.42000351
13Base excision repair_Homo sapiens_hsa034102.40449889
14Intestinal immune network for IgA production_Homo sapiens_hsa046722.27711478
15Oxidative phosphorylation_Homo sapiens_hsa001902.05588257
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.04027859
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.95650839
18RNA polymerase_Homo sapiens_hsa030201.94078542
19Parkinsons disease_Homo sapiens_hsa050121.87830040
20Systemic lupus erythematosus_Homo sapiens_hsa053221.87194671
21Ribosome_Homo sapiens_hsa030101.86729036
22Hematopoietic cell lineage_Homo sapiens_hsa046401.86617817
23Viral myocarditis_Homo sapiens_hsa054161.74499012
24Fanconi anemia pathway_Homo sapiens_hsa034601.73077725
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.54685343
26Pyrimidine metabolism_Homo sapiens_hsa002401.52126911
27One carbon pool by folate_Homo sapiens_hsa006701.49138208
28Nucleotide excision repair_Homo sapiens_hsa034201.48343310
29Spliceosome_Homo sapiens_hsa030401.45636591
30Protein export_Homo sapiens_hsa030601.43995346
31Rheumatoid arthritis_Homo sapiens_hsa053231.36431168
32Huntingtons disease_Homo sapiens_hsa050161.22357808
33Leishmaniasis_Homo sapiens_hsa051401.11303352
34Herpes simplex infection_Homo sapiens_hsa051681.08729180
35Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.05499782
36Purine metabolism_Homo sapiens_hsa002301.04949940
37RNA transport_Homo sapiens_hsa030131.01870420
38Alzheimers disease_Homo sapiens_hsa050101.00402926
39SNARE interactions in vesicular transport_Homo sapiens_hsa041300.94366130
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.89469363
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.88245320
42Fatty acid elongation_Homo sapiens_hsa000620.84028636
43Phototransduction_Homo sapiens_hsa047440.83715778
44Propanoate metabolism_Homo sapiens_hsa006400.83625923
45Shigellosis_Homo sapiens_hsa051310.77512597
46Cell cycle_Homo sapiens_hsa041100.73357518
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.72588315
48Measles_Homo sapiens_hsa051620.71981214
49Epstein-Barr virus infection_Homo sapiens_hsa051690.70759399
50Staphylococcus aureus infection_Homo sapiens_hsa051500.69156062
51RNA degradation_Homo sapiens_hsa030180.68275086
52Alcoholism_Homo sapiens_hsa050340.66694886
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65226250
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.64931893
55Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.64230359
56Basal transcription factors_Homo sapiens_hsa030220.63549880
57Salmonella infection_Homo sapiens_hsa051320.63405772
58Peroxisome_Homo sapiens_hsa041460.61238062
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60721399
60Regulation of autophagy_Homo sapiens_hsa041400.60694425
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59196730
62T cell receptor signaling pathway_Homo sapiens_hsa046600.55841872
63Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.54826918
64NF-kappa B signaling pathway_Homo sapiens_hsa040640.54753101
65Influenza A_Homo sapiens_hsa051640.53946057
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52434213
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.52208056
682-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48795872
69African trypanosomiasis_Homo sapiens_hsa051430.47075198
70RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.45558366
71Carbon metabolism_Homo sapiens_hsa012000.44278320
72N-Glycan biosynthesis_Homo sapiens_hsa005100.43037518
73NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42230836
74p53 signaling pathway_Homo sapiens_hsa041150.37803670
75Glutathione metabolism_Homo sapiens_hsa004800.37241420
76Viral carcinogenesis_Homo sapiens_hsa052030.37099712
77Legionellosis_Homo sapiens_hsa051340.36968891
78HTLV-I infection_Homo sapiens_hsa051660.36673871
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.36661034
80Tuberculosis_Homo sapiens_hsa051520.33010341
81Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.32827396
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.31338705
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31077065
84Metabolic pathways_Homo sapiens_hsa011000.29982179
85Pyruvate metabolism_Homo sapiens_hsa006200.29976249
86Pentose phosphate pathway_Homo sapiens_hsa000300.28118329
87mRNA surveillance pathway_Homo sapiens_hsa030150.27292314
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.26892567
89Cardiac muscle contraction_Homo sapiens_hsa042600.23747644
90Nitrogen metabolism_Homo sapiens_hsa009100.23324143
91Butanoate metabolism_Homo sapiens_hsa006500.23244144
92Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.22028406
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.21954888
94Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.20395554
95Sulfur metabolism_Homo sapiens_hsa009200.18978687
96Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.17188465
97Toxoplasmosis_Homo sapiens_hsa051450.16774567
98Olfactory transduction_Homo sapiens_hsa047400.16443451
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.16278339
100Toll-like receptor signaling pathway_Homo sapiens_hsa046200.13189379

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