SRM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The polyamines putrescine, spermine, and spermidine are ubiquitous polycationic mediators of cell growth and differentiation. Spermidine synthase is one of four enzymes in the polyamine-biosynthetic pathway and carries out the final step of spermidine biosynthesis. This enzyme catalyzes the conversion of putrescine to spermidine using decarboxylated S-adenosylmethionine as the cofactor. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.29833557
2ribosomal small subunit assembly (GO:0000028)5.36619275
3maturation of SSU-rRNA (GO:0030490)5.23367118
4viral transcription (GO:0019083)5.19474179
5DNA strand elongation involved in DNA replication (GO:0006271)5.18762972
6translational termination (GO:0006415)5.09819082
7formation of translation preinitiation complex (GO:0001731)5.01724303
8DNA replication initiation (GO:0006270)4.95881521
9folic acid-containing compound biosynthetic process (GO:0009396)4.95813184
10DNA strand elongation (GO:0022616)4.91358063
11telomere maintenance via semi-conservative replication (GO:0032201)4.84798542
12DNA unwinding involved in DNA replication (GO:0006268)4.78983212
13nucleobase biosynthetic process (GO:0046112)4.76194557
14ribosomal small subunit biogenesis (GO:0042274)4.71846547
15translational elongation (GO:0006414)4.68196045
16SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.56299207
17translational initiation (GO:0006413)4.52059117
18protein targeting to ER (GO:0045047)4.44127881
19cotranslational protein targeting to membrane (GO:0006613)4.43783123
20ribosome biogenesis (GO:0042254)4.39099235
21ribonucleoprotein complex biogenesis (GO:0022613)4.38390367
22regulation of translational fidelity (GO:0006450)4.30224024
23ribosomal large subunit biogenesis (GO:0042273)4.29786900
24ribosome assembly (GO:0042255)4.28835858
25pseudouridine synthesis (GO:0001522)4.22530605
26nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.22409060
27establishment of protein localization to endoplasmic reticulum (GO:0072599)4.21889799
28IMP biosynthetic process (GO:0006188)4.21076401
29protein localization to endoplasmic reticulum (GO:0070972)4.19565979
30purine nucleobase biosynthetic process (GO:0009113)4.18239850
31protein maturation by protein folding (GO:0022417)4.14243472
32telomere maintenance via recombination (GO:0000722)4.04807746
33proline biosynthetic process (GO:0006561)4.02963026
34cellular protein complex disassembly (GO:0043624)3.99862822
35viral life cycle (GO:0019058)3.96425727
36rRNA processing (GO:0006364)3.96190583
37DNA replication checkpoint (GO:0000076)3.89533575
38spliceosomal snRNP assembly (GO:0000387)3.84358574
39regulation of mammary gland epithelial cell proliferation (GO:0033599)3.81972693
40rRNA metabolic process (GO:0016072)3.80517017
41IMP metabolic process (GO:0046040)3.78762955
42mitotic chromosome condensation (GO:0007076)3.75619115
43telomere maintenance via telomere lengthening (GO:0010833)3.73480998
44folic acid metabolic process (GO:0046655)3.70130575
45mitotic recombination (GO:0006312)3.69966682
46nucleobase-containing small molecule interconversion (GO:0015949)3.69537779
47translation (GO:0006412)3.69276406
48protein localization to kinetochore (GO:0034501)3.66819605
49DNA replication-dependent nucleosome organization (GO:0034723)3.61733841
50DNA replication-dependent nucleosome assembly (GO:0006335)3.61733841
51protein complex disassembly (GO:0043241)3.61685386
52heterochromatin organization (GO:0070828)3.60667251
53proteasome assembly (GO:0043248)3.59998764
54mitotic nuclear envelope disassembly (GO:0007077)3.58487757
55pteridine-containing compound biosynthetic process (GO:0042559)3.53160250
56nucleotide-excision repair, DNA gap filling (GO:0006297)3.52679228
57deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.52397878
58pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.52205120
59establishment of integrated proviral latency (GO:0075713)3.50625882
60histone arginine methylation (GO:0034969)3.48310466
61regulation of mitochondrial translation (GO:0070129)3.47421225
62regulation of translational termination (GO:0006449)3.47199776
63macromolecular complex disassembly (GO:0032984)3.43371103
64negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.41910491
65rRNA transcription (GO:0009303)3.41488484
66ncRNA 3-end processing (GO:0043628)3.40882895
67regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.39512094
68pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.37366065
69nuclear-transcribed mRNA catabolic process (GO:0000956)3.35809886
70pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.31766041
71cellular component biogenesis (GO:0044085)3.31600848
72guanosine-containing compound biosynthetic process (GO:1901070)3.31558325
73negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.30631034
74nuclear envelope disassembly (GO:0051081)3.30551152
75membrane disassembly (GO:0030397)3.30551152
76chaperone-mediated protein transport (GO:0072321)3.29090751
77negative regulation of RNA splicing (GO:0033119)3.27829977
78UTP biosynthetic process (GO:0006228)3.26009708
79transcription from mitochondrial promoter (GO:0006390)3.21224702
80rRNA modification (GO:0000154)3.20752721
81negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.18907076
82mRNA catabolic process (GO:0006402)3.18416839
83protein targeting to mitochondrion (GO:0006626)3.17072871
84spliceosomal complex assembly (GO:0000245)3.15468535
85CENP-A containing nucleosome assembly (GO:0034080)3.15205163
86RNA catabolic process (GO:0006401)3.15184030
87chromatin remodeling at centromere (GO:0031055)3.14969432
88peptidyl-arginine omega-N-methylation (GO:0035247)3.13316032
89pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)3.10964759
90protein localization to chromosome, centromeric region (GO:0071459)3.07145204
91peptidyl-arginine N-methylation (GO:0035246)3.05434888
92peptidyl-arginine methylation (GO:0018216)3.05434888
93G1/S transition of mitotic cell cycle (GO:0000082)3.05056166
94cell cycle G1/S phase transition (GO:0044843)3.05056166
95anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.04665499
96transcription-coupled nucleotide-excision repair (GO:0006283)3.02766374
97pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.02626638
98GDP-mannose metabolic process (GO:0019673)3.02501305
99mitotic metaphase plate congression (GO:0007080)3.02019665
100L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.01160214
101regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.00946773
102DNA replication-independent nucleosome assembly (GO:0006336)3.00402906
103DNA replication-independent nucleosome organization (GO:0034724)3.00402906
104mitotic sister chromatid segregation (GO:0000070)2.98970899
105tRNA aminoacylation for protein translation (GO:0006418)2.98763059
106COPI coating of Golgi vesicle (GO:0048205)2.98578396
107Golgi transport vesicle coating (GO:0048200)2.98578396
108exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.98101247
109nuclear envelope reassembly (GO:0031468)2.97458376
110mitotic nuclear envelope reassembly (GO:0007084)2.97458376
111ncRNA processing (GO:0034470)2.97218502
112tRNA methylation (GO:0030488)2.97172210
113negative regulation of ligase activity (GO:0051352)2.96797065
114negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.96797065
115positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.96716493
116DNA duplex unwinding (GO:0032508)2.95516094
117transcription elongation from RNA polymerase III promoter (GO:0006385)2.94758559
118termination of RNA polymerase III transcription (GO:0006386)2.94758559
119viral mRNA export from host cell nucleus (GO:0046784)2.93265804
120DNA geometric change (GO:0032392)2.91848025
121negative regulation of mRNA processing (GO:0050686)2.91607958
122tRNA aminoacylation (GO:0043039)2.91127870
123amino acid activation (GO:0043038)2.91127870
124establishment of protein localization to mitochondrion (GO:0072655)2.90945086
125ncRNA metabolic process (GO:0034660)2.90271633
126protein complex localization (GO:0031503)2.90224111
127spliceosomal tri-snRNP complex assembly (GO:0000244)2.90171899
128protein targeting to membrane (GO:0006612)2.90087821
129pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.90065801
130CTP metabolic process (GO:0046036)2.89685865
131CTP biosynthetic process (GO:0006241)2.89685865
132termination of RNA polymerase II transcription (GO:0006369)2.87201920
133UTP metabolic process (GO:0046051)2.86874541
134mRNA splicing, via spliceosome (GO:0000398)2.86124525
135RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.86124525
136RNA splicing, via transesterification reactions (GO:0000375)2.85829212
137protein retention in ER lumen (GO:0006621)2.84434979
138oxidative phosphorylation (GO:0006119)2.81048406
139pentose metabolic process (GO:0019321)2.80783690
140maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.79303903
141L-serine metabolic process (GO:0006563)2.76658382
142negative regulation of mRNA metabolic process (GO:1903312)2.74696727
143positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.72519126
144deoxyribose phosphate biosynthetic process (GO:0046385)2.72299168
1452-deoxyribonucleotide biosynthetic process (GO:0009265)2.72299168
146pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.70015271

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.44340839
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.78433406
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.47898707
4* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.22143507
5* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.16113661
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.97908423
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.97849332
8* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.97803293
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.97000770
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.95484009
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.91842328
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.86029989
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.61126154
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.58361477
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.56014017
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.55450891
17XRN2_22483619_ChIP-Seq_HELA_Human2.48435201
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.47538580
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.24075666
20VDR_23849224_ChIP-Seq_CD4+_Human2.17727604
21ZNF263_19887448_ChIP-Seq_K562_Human2.15928620
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.13944444
23* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.09842677
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.07877540
25DCP1A_22483619_ChIP-Seq_HELA_Human2.05852645
26GABP_19822575_ChIP-Seq_HepG2_Human1.99806779
27THAP11_20581084_ChIP-Seq_MESCs_Mouse1.95610404
28ELF1_17652178_ChIP-ChIP_JURKAT_Human1.95445460
29* MYC_22102868_ChIP-Seq_BL_Human1.91356818
30FOXP3_21729870_ChIP-Seq_TREG_Human1.90851249
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.87549743
32TTF2_22483619_ChIP-Seq_HELA_Human1.87215456
33TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.86262173
34* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.84425512
35ZFX_18555785_ChIP-Seq_MESCs_Mouse1.75650767
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.74784590
37E2F1_21310950_ChIP-Seq_MCF-7_Human1.74768046
38PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.72695122
39AR_21909140_ChIP-Seq_LNCAP_Human1.72493311
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.72134210
41LXR_22292898_ChIP-Seq_THP-1_Human1.70496648
42* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.67073368
43* ELK3_25401928_ChIP-Seq_HUVEC_Human1.66652882
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.65225191
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.64589484
46CIITA_25753668_ChIP-Seq_RAJI_Human1.60543737
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59974189
48MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.56613835
49EGR1_19374776_ChIP-ChIP_THP-1_Human1.56116079
50* TET1_21451524_ChIP-Seq_MESCs_Mouse1.55928427
51CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.50543618
52FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.46637385
53KDM5A_27292631_Chip-Seq_BREAST_Human1.44234941
54VDR_21846776_ChIP-Seq_THP-1_Human1.42921939
55* RACK7_27058665_Chip-Seq_MCF-7_Human1.41671909
56ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.40324052
57* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.40006054
58STAT3_1855785_ChIP-Seq_MESCs_Mouse1.39938471
59CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.37688345
60SRF_21415370_ChIP-Seq_HL-1_Mouse1.37544617
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.36722151
62FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.36208624
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.35555036
64POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.34874936
65RARG_19884340_ChIP-ChIP_MEFs_Mouse1.34764915
66* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.33545338
67ERG_20887958_ChIP-Seq_HPC-7_Mouse1.33539405
68YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33197773
69E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.32720692
70ELK1_19687146_ChIP-ChIP_HELA_Human1.30828088
71* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.29293488
72DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.28813675
73KLF4_18555785_ChIP-Seq_MESCs_Mouse1.27828420
74NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.21803603
75* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.19178563
76P68_20966046_ChIP-Seq_HELA_Human1.17614453
77SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.17169715
78TFEB_21752829_ChIP-Seq_HELA_Human1.17039171
79* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15147888
80SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.14866874
81* SA1_27219007_Chip-Seq_ERYTHROID_Human1.10412718
82PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.09777393
83POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09644779
84ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.09422498
85ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09312055
86TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08763672
87KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.06833702
88KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06197805
89* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.05577450
90TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05085713
91TP63_17297297_ChIP-ChIP_HaCaT_Human1.04755815
92KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04591499
93SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.04572328
94ATF3_27146783_Chip-Seq_COLON_Human1.02593283
95CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01510133
96* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.00969904
97TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00916859
98NCOR1_26117541_ChIP-Seq_K562_Human1.00813907
99* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00535329
100* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00455861
101BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99767954
102TBX5_21415370_ChIP-Seq_HL-1_Mouse0.99584728
103ELF1_20517297_ChIP-Seq_JURKAT_Human0.99030318
104MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.97741531
105THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.97325599
106* MAF_26560356_Chip-Seq_TH2_Human0.96926066
107ELK1_22589737_ChIP-Seq_MCF10A_Human0.94655868
108CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93910737
109SRY_22984422_ChIP-ChIP_TESTIS_Rat0.93223395
110MYC_18940864_ChIP-ChIP_HL60_Human0.93213839
111HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93168436
112SPI1_23547873_ChIP-Seq_NB4_Human0.93061176
113* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.92004509
114TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.91422222
115SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.90299227
116DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.88929999
117* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88682540
118SOX2_18555785_ChIP-Seq_MESCs_Mouse0.86424723
119GATA1_22383799_ChIP-Seq_G1ME_Mouse0.85110859
120OCT4_18692474_ChIP-Seq_MEFs_Mouse0.84880530
121* FOXP1_21924763_ChIP-Seq_HESCs_Human0.84791662
122CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.84599868
123PADI4_21655091_ChIP-ChIP_MCF-7_Human0.83573937
124CTCF_18555785_ChIP-Seq_MESCs_Mouse0.80892921
125ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.80184008
126FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79953480

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.75094283
2MP0004957_abnormal_blastocyst_morpholog4.97667022
3MP0010094_abnormal_chromosome_stability4.36030354
4MP0003111_abnormal_nucleus_morphology4.30360045
5MP0003077_abnormal_cell_cycle3.86546412
6MP0008057_abnormal_DNA_replication3.85732730
7MP0002396_abnormal_hematopoietic_system3.19513021
8MP0008058_abnormal_DNA_repair3.09203997
9MP0008932_abnormal_embryonic_tissue2.79795180
10MP0008007_abnormal_cellular_replicative2.77338684
11MP0000678_abnormal_parathyroid_gland2.73178338
12MP0008438_abnormal_cutaneous_collagen2.72209210
13MP0005451_abnormal_body_composition2.54770723
14MP0010352_gastrointestinal_tract_polyps2.47147568
15MP0001730_embryonic_growth_arrest2.46006530
16MP0003806_abnormal_nucleotide_metabolis2.40992166
17MP0000350_abnormal_cell_proliferation2.32587756
18MP0003123_paternal_imprinting2.32130938
19MP0004858_abnormal_nervous_system2.30419528
20MP0000490_abnormal_crypts_of2.20999355
21MP0004185_abnormal_adipocyte_glucose2.14838778
22MP0005623_abnormal_meninges_morphology2.11606946
23MP0002249_abnormal_larynx_morphology2.05396491
24MP0003786_premature_aging1.90011128
25MP0005501_abnormal_skin_physiology1.84586688
26MP0009333_abnormal_splenocyte_physiolog1.83385479
27MP0001697_abnormal_embryo_size1.79863031
28MP0002080_prenatal_lethality1.79008396
29MP0002796_impaired_skin_barrier1.73999519
30MP0005397_hematopoietic_system_phenotyp1.68039767
31MP0001545_abnormal_hematopoietic_system1.68039767
32MP0001672_abnormal_embryogenesis/_devel1.67210893
33MP0005380_embryogenesis_phenotype1.67210893
34MP0006054_spinal_hemorrhage1.65992598
35MP0002163_abnormal_gland_morphology1.63836782
36MP0000313_abnormal_cell_death1.62970399
37MP0010307_abnormal_tumor_latency1.59477107
38MP0002019_abnormal_tumor_incidence1.56841824
39MP0004808_abnormal_hematopoietic_stem1.54043881
40MP0003984_embryonic_growth_retardation1.53798607
41MP0009379_abnormal_foot_pigmentation1.52437870
42MP0002085_abnormal_embryonic_tissue1.50338316
43MP0001661_extended_life_span1.50302449
44MP0002088_abnormal_embryonic_growth/wei1.48409537
45MP0000358_abnormal_cell_content/1.43451609
46MP0004197_abnormal_fetal_growth/weight/1.39657040
47MP0001348_abnormal_lacrimal_gland1.38564162
48MP0002084_abnormal_developmental_patter1.38417076
49MP0000733_abnormal_muscle_development1.38349202
50MP0008260_abnormal_autophagy1.36613085
51MP0003567_abnormal_fetal_cardiomyocyte1.36405334
52MP0002086_abnormal_extraembryonic_tissu1.35942869
53MP0003186_abnormal_redox_activity1.35428746
54MP0003718_maternal_effect1.33014186
55MP0005257_abnormal_intraocular_pressure1.29306339
56MP0000049_abnormal_middle_ear1.28038744
57MP0010030_abnormal_orbit_morphology1.26982877
58MP0003763_abnormal_thymus_physiology1.26402535
59MP0001849_ear_inflammation1.24113077
60MP0005670_abnormal_white_adipose1.22133321
61MP0004133_heterotaxia1.20611435
62MP0009053_abnormal_anal_canal1.20598965
63MP0002234_abnormal_pharynx_morphology1.19758592
64MP0000703_abnormal_thymus_morphology1.19352996
65MP0003566_abnormal_cell_adhesion1.18458330
66MP0002398_abnormal_bone_marrow1.17036932
67MP0002722_abnormal_immune_system1.17014262
68MP0001293_anophthalmia1.16619154
69MP0002060_abnormal_skin_morphology1.15737023
70MP0006036_abnormal_mitochondrial_physio1.13707149
71MP0009250_abnormal_appendicular_skeleto1.12854985
72MP0000689_abnormal_spleen_morphology1.11557296
73MP0001346_abnormal_lacrimal_gland1.11113630
74MP0003942_abnormal_urinary_system1.10725176
75MP0000759_abnormal_skeletal_muscle1.09611611
76MP0000003_abnormal_adipose_tissue1.08069579
77MP0006035_abnormal_mitochondrial_morpho1.05841121
78MP0000858_altered_metastatic_potential1.04742027
79MP0003656_abnormal_erythrocyte_physiolo1.04659012
80MP0001881_abnormal_mammary_gland1.02770146
81MP0005058_abnormal_lysosome_morphology1.02555797
82MP0001853_heart_inflammation0.98766998
83MP0005666_abnormal_adipose_tissue0.97158040
84MP0002429_abnormal_blood_cell0.96523587
85MP0005075_abnormal_melanosome_morpholog0.96268318
86MP0004272_abnormal_basement_membrane0.95585277
87MP0000681_abnormal_thyroid_gland0.95034519
88MP0005023_abnormal_wound_healing0.90969945
89MP0002160_abnormal_reproductive_system0.89922039
90MP0005375_adipose_tissue_phenotype0.89889277
91MP0000762_abnormal_tongue_morphology0.89248844
92MP0003705_abnormal_hypodermis_morpholog0.88675481
93MP0005384_cellular_phenotype0.88226479
94MP0005220_abnormal_exocrine_pancreas0.87979620
95MP0001145_abnormal_male_reproductive0.84730223
96MP0003119_abnormal_digestive_system0.82429568
97MP0000534_abnormal_ureter_morphology0.81035477
98MP0002111_abnormal_tail_morphology0.80479521
99MP0003221_abnormal_cardiomyocyte_apopto0.78663240
100MP0002210_abnormal_sex_determination0.78323716
101MP0000750_abnormal_muscle_regeneration0.78229914
102MP0003453_abnormal_keratinocyte_physiol0.77926827
103MP0002132_abnormal_respiratory_system0.77769173
104MP0000477_abnormal_intestine_morphology0.77172153
105MP0005076_abnormal_cell_differentiation0.76519299
106MP0003279_aneurysm0.76421464
107MP0005621_abnormal_cell_physiology0.75972827
108MP0001915_intracranial_hemorrhage0.75758908
109MP0003385_abnormal_body_wall0.75477905
110MP0001873_stomach_inflammation0.74333659
111MP0005174_abnormal_tail_pigmentation0.73844429
112MP0005503_abnormal_tendon_morphology0.73676770
113MP0009672_abnormal_birth_weight0.73576064
114MP0000716_abnormal_immune_system0.73359538
115MP0005266_abnormal_metabolism0.73333040
116MP0000462_abnormal_digestive_system0.72564367
117MP0008877_abnormal_DNA_methylation0.72425199
118MP0005330_cardiomyopathy0.72412658
119MP0000537_abnormal_urethra_morphology0.71729766
120MP0005508_abnormal_skeleton_morphology0.71066727
121MP0000467_abnormal_esophagus_morphology0.69801799
122MP0002697_abnormal_eye_size0.69586626
123MP0003890_abnormal_embryonic-extraembry0.69105330
124MP0002114_abnormal_axial_skeleton0.68780424
125MP0006292_abnormal_olfactory_placode0.68119424
126MP0002089_abnormal_postnatal_growth/wei0.67944767
127MP0003315_abnormal_perineum_morphology0.67906814
128MP0009931_abnormal_skin_appearance0.66969316
129MP0000751_myopathy0.65851393
130MP0000465_gastrointestinal_hemorrhage0.65541752
131MP0008770_decreased_survivor_rate0.65509585
132MP0002877_abnormal_melanocyte_morpholog0.65201208
133MP0003941_abnormal_skin_development0.64994501
134MP0005389_reproductive_system_phenotype0.64763261
135MP0002405_respiratory_system_inflammati0.64249599
136MP0002653_abnormal_ependyma_morphology0.64035315
137MP0000653_abnormal_sex_gland0.62696993
138MP0000685_abnormal_immune_system0.60214357
139MP0004233_abnormal_muscle_weight0.59623979
140MP0009278_abnormal_bone_marrow0.58867397
141MP0002095_abnormal_skin_pigmentation0.58858067
142MP0002075_abnormal_coat/hair_pigmentati0.56882850
143MP0004147_increased_porphyrin_level0.56120610
144MP0003121_genomic_imprinting0.55737366
145MP0000598_abnormal_liver_morphology0.54912141
146MP0002938_white_spotting0.54832434
147MP0001929_abnormal_gametogenesis0.54043031
148MP0002269_muscular_atrophy0.52737763
149MP0000428_abnormal_craniofacial_morphol0.51703666

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)6.30642759
2Abnormal number of erythroid precursors (HP:0012131)6.13279686
3Reticulocytopenia (HP:0001896)5.12532510
4Aplastic anemia (HP:0001915)4.60591568
5Birth length less than 3rd percentile (HP:0003561)4.55384480
6Oral leukoplakia (HP:0002745)4.15890184
7Macrocytic anemia (HP:0001972)3.85081570
8Pallor (HP:0000980)3.73962575
9Selective tooth agenesis (HP:0001592)3.60948869
10Breast hypoplasia (HP:0003187)3.50987474
11Premature rupture of membranes (HP:0001788)3.43693717
12Cerebral hypomyelination (HP:0006808)3.37908369
13Rough bone trabeculation (HP:0100670)3.33671187
14Microretrognathia (HP:0000308)3.21439088
15Abnormality of the anterior horn cell (HP:0006802)3.20515591
16Degeneration of anterior horn cells (HP:0002398)3.20515591
17Multiple enchondromatosis (HP:0005701)3.09828175
18Colon cancer (HP:0003003)3.08281113
19Thrombocytosis (HP:0001894)3.00838914
20Trismus (HP:0000211)3.00786737
21Ependymoma (HP:0002888)2.97005846
22Progressive muscle weakness (HP:0003323)2.95437072
23Truncus arteriosus (HP:0001660)2.95197037
24Carpal bone hypoplasia (HP:0001498)2.94710663
25Premature graying of hair (HP:0002216)2.92220268
26Achilles tendon contracture (HP:0001771)2.89061605
27Type I transferrin isoform profile (HP:0003642)2.86610865
28Ragged-red muscle fibers (HP:0003200)2.84653210
29Hyperacusis (HP:0010780)2.79394593
30Premature skin wrinkling (HP:0100678)2.79089042
31Decreased activity of mitochondrial respiratory chain (HP:0008972)2.71021906
32Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.71021906
33Broad distal phalanx of finger (HP:0009836)2.66340375
3411 pairs of ribs (HP:0000878)2.64003369
35Abnormality of the heme biosynthetic pathway (HP:0010472)2.61772361
36Absent thumb (HP:0009777)2.59065653
37Myopathic facies (HP:0002058)2.58757549
38Hyperthyroidism (HP:0000836)2.57246611
39Abnormality of the umbilical cord (HP:0010881)2.57044471
40Abnormality of the fetal cardiovascular system (HP:0010948)2.54277932
41Abnormal umbilical cord blood vessels (HP:0011403)2.54277932
42Single umbilical artery (HP:0001195)2.54277932
43Testicular atrophy (HP:0000029)2.53006882
44Patellar aplasia (HP:0006443)2.50277186
45Unilateral renal agenesis (HP:0000122)2.48174226
46Medulloblastoma (HP:0002885)2.46503688
47Abnormality of the Achilles tendon (HP:0005109)2.46185976
48Pancytopenia (HP:0001876)2.41764710
49Redundant skin (HP:0001582)2.40653701
50Reduced antithrombin III activity (HP:0001976)2.40260834
51Abnormal number of incisors (HP:0011064)2.36477234
52Aplasia/Hypoplasia of the patella (HP:0006498)2.35641405
53Abnormality of reticulocytes (HP:0004312)2.34910351
54Aplasia/Hypoplasia of the sacrum (HP:0008517)2.34745503
55Basal cell carcinoma (HP:0002671)2.34702856
56Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.32791900
57Abnormal protein N-linked glycosylation (HP:0012347)2.32791900
58Abnormal protein glycosylation (HP:0012346)2.32791900
59Abnormal glycosylation (HP:0012345)2.32791900
60Ulnar bowing (HP:0003031)2.32552339
61Megaloblastic anemia (HP:0001889)2.32203230
62Insomnia (HP:0100785)2.32161138
63Double outlet right ventricle (HP:0001719)2.31777062
64Congenital malformation of the right heart (HP:0011723)2.31777062
65Neoplasm of the pancreas (HP:0002894)2.31459520
66Vertebral compression fractures (HP:0002953)2.31026986
67Abnormal mitochondria in muscle tissue (HP:0008316)2.30535197
68Disproportionate tall stature (HP:0001519)2.29691099
69Premature ovarian failure (HP:0008209)2.28519508
70Glossoptosis (HP:0000162)2.28371135
71Myelodysplasia (HP:0002863)2.27371026
72Abnormal trabecular bone morphology (HP:0100671)2.27169483
73Increased serum lactate (HP:0002151)2.26528271
74Agnosia (HP:0010524)2.26114112
75Elbow flexion contracture (HP:0002987)2.26091607
76Generalized amyotrophy (HP:0003700)2.25290124
77Hypertensive crisis (HP:0100735)2.24853301
78Atrophy/Degeneration involving motor neurons (HP:0007373)2.24494220
79Bone marrow hypocellularity (HP:0005528)2.22899583
80Cholecystitis (HP:0001082)2.22561344
81Abnormal gallbladder physiology (HP:0012438)2.22561344
82Fragile skin (HP:0001030)2.21101288
83Abnormality of the preputium (HP:0100587)2.21085663
84Abnormality of the tricuspid valve (HP:0001702)2.20796398
85Spinal rigidity (HP:0003306)2.18977329
86Meckel diverticulum (HP:0002245)2.18205950
87Slender long bone (HP:0003100)2.18130883
88Secondary amenorrhea (HP:0000869)2.18039918
89Abnormality of the ileum (HP:0001549)2.16777341
90Patellar dislocation (HP:0002999)2.15840832
91Poor head control (HP:0002421)2.15648147
92Missing ribs (HP:0000921)2.15603323
93Long palpebral fissure (HP:0000637)2.15521194
94Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.15188931
95Nonimmune hydrops fetalis (HP:0001790)2.14700354
96Hypoplastic left heart (HP:0004383)2.10147334
97Hypoplasia of the pons (HP:0012110)2.08909555
98Chromsome breakage (HP:0040012)2.07424754
99CNS hypomyelination (HP:0003429)2.03602258
100Rhabdomyosarcoma (HP:0002859)2.03316952
101Absent radius (HP:0003974)2.01781573
102Cellular immunodeficiency (HP:0005374)2.01311117
103Atresia of the external auditory canal (HP:0000413)2.00303818
104Acute necrotizing encephalopathy (HP:0006965)2.00073270
105Septate vagina (HP:0001153)1.98662375
106Postnatal microcephaly (HP:0005484)1.98608706
107Ankle contracture (HP:0006466)1.98600756
108Abnormality of chromosome stability (HP:0003220)1.97820790
109Chromosomal breakage induced by crosslinking agents (HP:0003221)1.97250214
110Squamous cell carcinoma (HP:0002860)1.96174566
111Genu recurvatum (HP:0002816)1.94975520
112Sparse eyelashes (HP:0000653)1.94216161
113Abnormal ventriculo-arterial connection (HP:0011563)1.93607460
114Transposition of the great arteries (HP:0001669)1.93607460
115Abnormal connection of the cardiac segments (HP:0011545)1.93607460
116Horseshoe kidney (HP:0000085)1.92390040
117Microvesicular hepatic steatosis (HP:0001414)1.92220511
118Abnormality of the pons (HP:0007361)1.91724026
119Reduced subcutaneous adipose tissue (HP:0003758)1.91499060
120Tracheoesophageal fistula (HP:0002575)1.91157876
121Biconcave vertebral bodies (HP:0004586)1.89120942
122Seborrheic dermatitis (HP:0001051)1.86579409
123Aplasia/Hypoplasia of the uvula (HP:0010293)1.85842238
124Acute encephalopathy (HP:0006846)1.85490722
125Stridor (HP:0010307)1.85208707
126Increased connective tissue (HP:0009025)1.85108815
127Protrusio acetabuli (HP:0003179)1.84621019
128Absent forearm bone (HP:0003953)1.84532564
129Aplasia involving forearm bones (HP:0009822)1.84532564
130Hepatocellular necrosis (HP:0001404)1.83841188
131Irregular epiphyses (HP:0010582)1.83138573
132Lymphoma (HP:0002665)1.82804883
133Adenoma sebaceum (HP:0009720)1.82736116
134Angiofibromas (HP:0010615)1.82736116
135Sparse lateral eyebrow (HP:0005338)1.82417308
136Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.82064238
137Renal duplication (HP:0000075)1.81899639
138Poikiloderma (HP:0001029)1.80852813
139Exercise intolerance (HP:0003546)1.79789601
140Increased intramyocellular lipid droplets (HP:0012240)1.79362131
141Hypoplasia of the radius (HP:0002984)1.79276695
142IgM deficiency (HP:0002850)1.77653805
143Abnormality of the phalanges of the hallux (HP:0010057)1.77175252
144Increased serum pyruvate (HP:0003542)1.76148002
145Abnormality of glycolysis (HP:0004366)1.76148002
146Proximal placement of thumb (HP:0009623)1.76067267
147Distal upper limb amyotrophy (HP:0007149)1.75148273
148Upper limb amyotrophy (HP:0009129)1.75148273
149Personality changes (HP:0000751)1.75097940
150Overriding aorta (HP:0002623)1.74763207
151Abnormality of the aortic arch (HP:0012303)1.74634325
152Abnormality of the calcaneus (HP:0008364)1.74501599
153Hypokinesia (HP:0002375)1.74433189
154Prominent nose (HP:0000448)1.73592992
155Abnormality of the distal phalanges of the toes (HP:0010182)1.72818614
156Increased hepatocellular lipid droplets (HP:0006565)1.72758505
157Muscle fiber atrophy (HP:0100295)1.71930678
158Asplenia (HP:0001746)1.71858119
159Hypoparathyroidism (HP:0000829)1.71698691
160Emotional lability (HP:0000712)1.71368903
161Increased muscle lipid content (HP:0009058)1.70837810
162Deep palmar crease (HP:0006191)1.70192296
163Tongue fasciculations (HP:0001308)1.69765642
164Self-mutilation (HP:0000742)1.67873352
165Hypergonadotropic hypogonadism (HP:0000815)1.67151555
166Centrally nucleated skeletal muscle fibers (HP:0003687)1.66357254
167Slender build (HP:0001533)1.66303990
168Blue sclerae (HP:0000592)1.66066459
169Spinal cord compression (HP:0002176)1.65868350
170Increased CSF lactate (HP:0002490)1.64387687
171Ileus (HP:0002595)1.62740214

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.39814427
2SMG14.39390141
3WEE14.18447337
4VRK23.59444286
5CDC73.44852634
6NME23.44722057
7IRAK33.41962209
8EIF2AK13.18652692
9STK162.82844224
10SCYL22.73816214
11TESK22.70419797
12EIF2AK32.54874262
13ICK2.49773304
14TSSK62.19094263
15EEF2K2.07041098
16PIM21.99906135
17ACVR1B1.97814450
18NEK21.97082975
19SRPK11.92997215
20RPS6KB21.92235713
21CDK71.81560810
22VRK11.79100832
23NEK11.74901483
24PRPF4B1.70922365
25PASK1.69831667
26ARAF1.69393806
27PRKD31.63804798
28DYRK31.61887995
29MAP3K111.61225943
30TTK1.60224045
31RPS6KA41.53686931
32TAF11.52226284
33PLK11.51758480
34SIK11.50515641
35KDR1.50220005
36BRSK21.42362102
37FLT31.41749663
38ATR1.39345546
39TLK11.37416744
40MAP3K81.36069013
41BCKDK1.30707778
42AURKA1.30667970
43AURKB1.30163099
44MAPKAPK31.26754539
45PLK41.26404059
46PKN21.25742669
47MKNK11.25545001
48CDK41.23134146
49ERN11.18389610
50TESK11.16848206
51PAK41.14932373
52PBK1.13537939
53LRRK21.09593535
54MAP4K11.08971697
55MAP2K31.06833602
56CDK191.06719460
57CHEK21.05443511
58MAP3K101.00975465
59TTN0.97464805
60BRSK10.96952362
61TGFBR10.96734958
62CHEK10.95879929
63NME10.93196320
64STK100.90637959
65EPHA20.88660640
66PAK10.87205166
67IRAK20.83533583
68TRIB30.79725192
69CSNK2A20.78999558
70PTK20.77324769
71MKNK20.74444064
72PLK30.72438045
73MAPK110.72221033
74TAOK20.71716529
75CDK20.71089279
76PIM10.71039493
77ALK0.69677082
78CDK80.68047830
79CDK120.67734998
80CSNK2A10.66120498
81RAF10.65569614
82CAMK1D0.63536518
83ILK0.63148694
84PAK20.62896199
85CLK10.60366799
86CCNB10.60248071
87LIMK10.58123858
88DMPK0.57763898
89KSR20.57561097
90ZAP700.57258493
91BTK0.56660052
92ATM0.54935627
93DAPK30.54801907
94DAPK10.53688123
95BRAF0.51763863
96CDK90.51574836
97LATS20.50029963
98MAP3K30.49829507
99AKT20.49375455
100TAOK10.48555543
101ABL20.48349803
102PRKCI0.48337161
103BMX0.47027744
104MOS0.45910408
105GRK60.45365240
106PDGFRA0.45254864
107MAPKAPK50.44911208
108TEC0.44673023
109PRKD20.42501281
110PDK20.41834941
111MTOR0.40775421
112CDK150.40559732
113EIF2AK20.40520966
114MAP2K20.39650946
115CSF1R0.39561093
116CDK10.38669563
117IRAK40.38213152
118NTRK10.37940114
119RPS6KL10.37092646
120RPS6KC10.37092646
121MAP3K130.36717765
122CSNK1E0.35547349
123PDPK10.35392717
124BLK0.34503066
125KIT0.33515850
126MATK0.31994353
127JAK30.31371944
128STK40.31142151
129DYRK20.30615004
130RPS6KA50.26265582
131MAP3K50.25712693
132CDK11A0.25624336
133PNCK0.24915649
134CDK60.24097739

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.26816542
2Ribosome_Homo sapiens_hsa030104.57091899
3Mismatch repair_Homo sapiens_hsa034304.13119833
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.71350860
5Proteasome_Homo sapiens_hsa030503.53840419
6Spliceosome_Homo sapiens_hsa030403.24346616
7RNA polymerase_Homo sapiens_hsa030203.22226945
8One carbon pool by folate_Homo sapiens_hsa006702.99637524
9Base excision repair_Homo sapiens_hsa034102.97570372
10RNA transport_Homo sapiens_hsa030132.93777186
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.76713871
12Nucleotide excision repair_Homo sapiens_hsa034202.73175060
13Homologous recombination_Homo sapiens_hsa034402.69901242
14Pyrimidine metabolism_Homo sapiens_hsa002402.68252571
15Cell cycle_Homo sapiens_hsa041102.19165164
16Fanconi anemia pathway_Homo sapiens_hsa034601.72058022
17RNA degradation_Homo sapiens_hsa030181.69518273
18Non-homologous end-joining_Homo sapiens_hsa034501.57486370
19Folate biosynthesis_Homo sapiens_hsa007901.54016103
20Protein export_Homo sapiens_hsa030601.43985984
21p53 signaling pathway_Homo sapiens_hsa041151.34785126
22Purine metabolism_Homo sapiens_hsa002301.34429968
23Sulfur relay system_Homo sapiens_hsa041221.34254006
24Basal transcription factors_Homo sapiens_hsa030221.32717052
25Biosynthesis of amino acids_Homo sapiens_hsa012301.26449233
26Cyanoamino acid metabolism_Homo sapiens_hsa004601.26431817
27mRNA surveillance pathway_Homo sapiens_hsa030151.22348217
28Pentose phosphate pathway_Homo sapiens_hsa000301.21163092
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.09652029
30Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.07749681
31N-Glycan biosynthesis_Homo sapiens_hsa005101.05442319
32Epstein-Barr virus infection_Homo sapiens_hsa051691.00901371
33* Cysteine and methionine metabolism_Homo sapiens_hsa002700.98199598
34Selenocompound metabolism_Homo sapiens_hsa004500.96420121
35Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.91160826
36Non-small cell lung cancer_Homo sapiens_hsa052230.84921994
37Drug metabolism - other enzymes_Homo sapiens_hsa009830.84370015
38Parkinsons disease_Homo sapiens_hsa050120.81546250
39Antigen processing and presentation_Homo sapiens_hsa046120.79222049
40Pancreatic cancer_Homo sapiens_hsa052120.78115902
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.78034802
42Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.77474453
43Prion diseases_Homo sapiens_hsa050200.76807152
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75707154
45Vibrio cholerae infection_Homo sapiens_hsa051100.74205669
46Viral carcinogenesis_Homo sapiens_hsa052030.73385045
47Huntingtons disease_Homo sapiens_hsa050160.72856276
48Systemic lupus erythematosus_Homo sapiens_hsa053220.72157755
49Carbon metabolism_Homo sapiens_hsa012000.71620825
50Thyroid cancer_Homo sapiens_hsa052160.70322070
51Herpes simplex infection_Homo sapiens_hsa051680.68149040
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.63046248
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59955622
54Galactose metabolism_Homo sapiens_hsa000520.58667174
55VEGF signaling pathway_Homo sapiens_hsa043700.56834249
56Oxidative phosphorylation_Homo sapiens_hsa001900.55689195
57Fatty acid elongation_Homo sapiens_hsa000620.54447884
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53668930
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53399858
60HTLV-I infection_Homo sapiens_hsa051660.52747516
61Oocyte meiosis_Homo sapiens_hsa041140.52612740
62Glioma_Homo sapiens_hsa052140.52401749
63Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52068318
64Legionellosis_Homo sapiens_hsa051340.50667785
65Sulfur metabolism_Homo sapiens_hsa009200.50294635
66Melanoma_Homo sapiens_hsa052180.49862466
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49594095
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49438331
69Fructose and mannose metabolism_Homo sapiens_hsa000510.49204545
70Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47896969
71Bladder cancer_Homo sapiens_hsa052190.44963729
72Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.44898321
73Basal cell carcinoma_Homo sapiens_hsa052170.43434606
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42726790
75Vitamin B6 metabolism_Homo sapiens_hsa007500.42059214
76Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41258090
77Shigellosis_Homo sapiens_hsa051310.39913252
78Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39445256
79Endometrial cancer_Homo sapiens_hsa052130.38438583
80Insulin signaling pathway_Homo sapiens_hsa049100.38350631
81Renin-angiotensin system_Homo sapiens_hsa046140.37790885
82Prostate cancer_Homo sapiens_hsa052150.37313590
83* Glutathione metabolism_Homo sapiens_hsa004800.37189867
84Small cell lung cancer_Homo sapiens_hsa052220.36423128
85Apoptosis_Homo sapiens_hsa042100.36056982
86Lysine degradation_Homo sapiens_hsa003100.35323898
87Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.35149301
88Central carbon metabolism in cancer_Homo sapiens_hsa052300.35148962
89AMPK signaling pathway_Homo sapiens_hsa041520.35101804
90* Metabolic pathways_Homo sapiens_hsa011000.34270065
91Acute myeloid leukemia_Homo sapiens_hsa052210.34209900
92Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.32937373
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30701371
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.30179352
95Cardiac muscle contraction_Homo sapiens_hsa042600.29580575
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.28575077
97Renal cell carcinoma_Homo sapiens_hsa052110.28148879
98Primary immunodeficiency_Homo sapiens_hsa053400.25772278
99Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.25341974
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.25129015
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.24920174
102Hepatitis B_Homo sapiens_hsa051610.24814382
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24678079
104Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24431607
105MicroRNAs in cancer_Homo sapiens_hsa052060.23498936
106HIF-1 signaling pathway_Homo sapiens_hsa040660.21716647
107Alcoholism_Homo sapiens_hsa050340.19727327
108Colorectal cancer_Homo sapiens_hsa052100.19460247
109Alzheimers disease_Homo sapiens_hsa050100.18835372
110Chronic myeloid leukemia_Homo sapiens_hsa052200.17743423
111Notch signaling pathway_Homo sapiens_hsa043300.13490772
112Measles_Homo sapiens_hsa051620.13305661
113TGF-beta signaling pathway_Homo sapiens_hsa043500.11628962
114* Arginine and proline metabolism_Homo sapiens_hsa003300.09606938
115RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.09356930
116Other glycan degradation_Homo sapiens_hsa005110.09113106
117Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.08043600
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.06452371
119Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.05411466
120Pathways in cancer_Homo sapiens_hsa052000.04973021
121Pyruvate metabolism_Homo sapiens_hsa006200.04265150
122mTOR signaling pathway_Homo sapiens_hsa041500.04228313
123Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.03295758
124Hematopoietic cell lineage_Homo sapiens_hsa046400.02853605
125Influenza A_Homo sapiens_hsa051640.01653639

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