SRF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* sarcomere organization (GO:0045214)5.88275448
2* cardiac myofibril assembly (GO:0055003)5.61966822
3negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.25972176
4plasma membrane repair (GO:0001778)4.93144383
5negative regulation of potassium ion transmembrane transport (GO:1901380)4.76337384
6* myofibril assembly (GO:0030239)4.71503003
7actin-myosin filament sliding (GO:0033275)4.51214181
8muscle filament sliding (GO:0030049)4.51214181
9cardiac muscle cell development (GO:0055013)4.46722344
10negative regulation of erythrocyte differentiation (GO:0045647)4.30595471
11cardiac cell development (GO:0055006)4.28828408
12cardiac muscle contraction (GO:0060048)4.06922195
13* actomyosin structure organization (GO:0031032)4.00809191
14actin-mediated cell contraction (GO:0070252)3.72287919
15bundle of His cell to Purkinje myocyte communication (GO:0086069)3.65912490
16cell-substrate junction assembly (GO:0007044)3.65653413
17regulation of cardioblast differentiation (GO:0051890)3.62857012
18regulation of early endosome to late endosome transport (GO:2000641)3.59306144
19adult heart development (GO:0007512)3.57566760
20cardiac muscle tissue morphogenesis (GO:0055008)3.53460093
21ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.50942614
22regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.47544215
23* heart trabecula formation (GO:0060347)3.46137457
24cell-substrate adherens junction assembly (GO:0007045)3.45040425
25focal adhesion assembly (GO:0048041)3.45040425
26adherens junction assembly (GO:0034333)3.43322484
27apoptotic process involved in morphogenesis (GO:0060561)3.43227061
28negative regulation of cell size (GO:0045792)3.39814277
29ventricular cardiac muscle cell action potential (GO:0086005)3.35906234
30actin filament-based movement (GO:0030048)3.35094223
31protein localization to endosome (GO:0036010)3.32593218
32pinocytosis (GO:0006907)3.30660746
33negative regulation of fatty acid transport (GO:2000192)3.30637055
34embryonic process involved in female pregnancy (GO:0060136)3.30186956
35regulation of p38MAPK cascade (GO:1900744)3.25983923
36positive regulation of histone deacetylation (GO:0031065)3.25167876
37hemidesmosome assembly (GO:0031581)3.25012249
38desmosome organization (GO:0002934)3.21585894
39muscle tissue morphogenesis (GO:0060415)3.20963125
40positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.19448626
41regulation of actin filament-based movement (GO:1903115)3.14579427
42regulation of skeletal muscle contraction (GO:0014819)3.14156534
43regulation of NFAT protein import into nucleus (GO:0051532)3.13848834
44response to laminar fluid shear stress (GO:0034616)3.11860211
45regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.10215218
46cardiac muscle hypertrophy (GO:0003300)3.07273347
47regulation of tight junction assembly (GO:2000810)3.06347284
48striated muscle contraction (GO:0006941)3.03925630
49activation of MAPKKK activity (GO:0000185)2.99516565
50negative regulation of cardiac muscle tissue growth (GO:0055022)2.98984349
51negative regulation of heart growth (GO:0061117)2.98984349
52regulation of hippo signaling (GO:0035330)2.96597909
53regulation of the force of heart contraction (GO:0002026)2.95111747
54ventricular cardiac muscle cell development (GO:0055015)2.91133285
55striated muscle hypertrophy (GO:0014897)2.90886402
56cellular protein complex localization (GO:0034629)2.90703263
57negative regulation of nucleotide catabolic process (GO:0030812)2.88174484
58modulation by symbiont of host cellular process (GO:0044068)2.87922022
59mannose metabolic process (GO:0006013)2.87869980
60cytoskeletal anchoring at plasma membrane (GO:0007016)2.85991924
61regulation of glucose import in response to insulin stimulus (GO:2001273)2.85539462
62positive regulation of myotube differentiation (GO:0010831)2.85161838
63regulation of histone H3-K27 methylation (GO:0061085)2.83690697
64positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.77486462
65cardiac muscle cell proliferation (GO:0060038)2.77115187
66barbed-end actin filament capping (GO:0051016)2.76695738
67intracellular estrogen receptor signaling pathway (GO:0030520)2.74522204
68atrioventricular valve morphogenesis (GO:0003181)2.72230091
69regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.71503040
70cell-cell junction maintenance (GO:0045217)2.71387197
71regulation of mammary gland epithelial cell proliferation (GO:0033599)2.69888163
72hippo signaling (GO:0035329)2.67275023
73basement membrane organization (GO:0071711)2.65670782
74endothelial cell chemotaxis (GO:0035767)2.64714054
75regulation of RNA export from nucleus (GO:0046831)2.64641355
76vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.63943989
77negative regulation of purine nucleotide catabolic process (GO:0033122)2.63728368
78cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.63379980
79regulation of nucleobase-containing compound transport (GO:0032239)2.62761026
80heart morphogenesis (GO:0003007)2.61705097
81pre-miRNA processing (GO:0031054)2.60476875
82* epithelial cell-cell adhesion (GO:0090136)2.60125279
83mitotic chromosome condensation (GO:0007076)2.59406018
84peptidyl-lysine dimethylation (GO:0018027)2.59036673
85atrial septum morphogenesis (GO:0060413)2.59028433
86negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.58262264
87negative regulation of striated muscle cell differentiation (GO:0051154)2.58085076
88regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.57545600
89activation of Rac GTPase activity (GO:0032863)2.57512701
90cytoplasmic mRNA processing body assembly (GO:0033962)2.57492381
91modulation by virus of host process (GO:0019054)2.55511050
92negative regulation of striated muscle cell apoptotic process (GO:0010664)2.55466056
93positive regulation of blood vessel endothelial cell migration (GO:0043536)2.54781411
94heterochromatin organization (GO:0070828)2.54462626
95* trabecula formation (GO:0060343)2.54327831
96negative regulation of potassium ion transport (GO:0043267)2.53732354
97positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.53425572
98negative regulation of myotube differentiation (GO:0010832)2.52456676
99proline biosynthetic process (GO:0006561)2.51994791
100positive regulation of Cdc42 GTPase activity (GO:0043089)2.51702541
101apoptotic process involved in development (GO:1902742)2.51506179
102epithelial cell differentiation involved in prostate gland development (GO:0060742)2.51150260
103regulation of SMAD protein import into nucleus (GO:0060390)2.50455113
104maternal placenta development (GO:0001893)2.49846205
105insulin-like growth factor receptor signaling pathway (GO:0048009)2.49829890
106positive regulation of SMAD protein import into nucleus (GO:0060391)2.49521761
107RNA stabilization (GO:0043489)2.49447449
108mRNA stabilization (GO:0048255)2.49447449
109establishment of apical/basal cell polarity (GO:0035089)2.49155520
110protein heterotrimerization (GO:0070208)2.48760085
111cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.48096597
112vascular endothelial growth factor signaling pathway (GO:0038084)2.47773292
113polarized epithelial cell differentiation (GO:0030859)2.47685060
114striated muscle cell development (GO:0055002)2.46812502
115protein hydroxylation (GO:0018126)2.46712248
116regulation of integrin activation (GO:0033623)2.46130430
117regulation of striated muscle contraction (GO:0006942)2.45866803
118cardiac muscle hypertrophy in response to stress (GO:0014898)2.45731582
119muscle hypertrophy in response to stress (GO:0003299)2.45731582
120cardiac muscle adaptation (GO:0014887)2.45731582
121regulation of translational fidelity (GO:0006450)2.45517978
122outflow tract septum morphogenesis (GO:0003148)2.45475461
123cell communication involved in cardiac conduction (GO:0086065)2.45255304
124regulation of sarcomere organization (GO:0060297)2.43884474
1253-UTR-mediated mRNA stabilization (GO:0070935)2.42131188
126negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.41736465
127muscle hypertrophy (GO:0014896)2.40228164
128Golgi transport vesicle coating (GO:0048200)2.39578302
129COPI coating of Golgi vesicle (GO:0048205)2.39578302
130carnitine shuttle (GO:0006853)2.37309927
131planar cell polarity pathway involved in neural tube closure (GO:0090179)2.36790952
132cellular response to epidermal growth factor stimulus (GO:0071364)2.36455154
133protein complex localization (GO:0031503)2.35975945
134* stress fiber assembly (GO:0043149)2.35276705
135glucocorticoid receptor signaling pathway (GO:0042921)2.34183849
136fibroblast migration (GO:0010761)2.33144755
137convergent extension (GO:0060026)2.33009448
138regulation of extracellular matrix disassembly (GO:0010715)2.32408266
139regulation of chromatin binding (GO:0035561)2.32384588
140histone H3-K36 demethylation (GO:0070544)2.30652411
141trophoblast giant cell differentiation (GO:0060707)2.29172940
142modulation by virus of host morphology or physiology (GO:0019048)2.27598349
143activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.27221475
144Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.25878406
145regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.25791351
146DNA unwinding involved in DNA replication (GO:0006268)2.25603896
147regulation of apoptotic process involved in morphogenesis (GO:1902337)2.25313301
148cortical actin cytoskeleton organization (GO:0030866)2.25229754
149positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.24144384
150positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.22983976
151regulation of type I interferon-mediated signaling pathway (GO:0060338)2.22930296
152negative regulation of skeletal muscle tissue development (GO:0048642)2.22825290
153negative regulation of viral release from host cell (GO:1902187)2.21826512
154pentose-phosphate shunt (GO:0006098)2.20396895
155positive regulation of nuclease activity (GO:0032075)2.20277563
156intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.19945240
157regulation of glucocorticoid metabolic process (GO:0031943)2.17850572
158positive regulation by organism of defense response of other organism involved in symbiotic interact2.17843647
159modulation by symbiont of host immune response (GO:0052553)2.17843647
160positive regulation by symbiont of host defense response (GO:0052509)2.17843647
161modulation by symbiont of host defense response (GO:0052031)2.17843647
162modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.17843647
163modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.17843647
164positive regulation of protein dephosphorylation (GO:0035307)2.16944511
165embryonic eye morphogenesis (GO:0048048)2.16925637
166semaphorin-plexin signaling pathway (GO:0071526)2.16524093
167response to fluid shear stress (GO:0034405)2.16219301
168germinal center formation (GO:0002467)2.16161514
169response to muramyl dipeptide (GO:0032495)2.15952055
170positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.14942228
171negative regulation of necroptotic process (GO:0060546)2.14527505
172protein targeting to plasma membrane (GO:0072661)2.14317846
173NIK/NF-kappaB signaling (GO:0038061)2.14247509
174hypotonic response (GO:0006971)2.13929822
175regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.12969110

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.77545214
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.51798547
3MYC_22102868_ChIP-Seq_BL_Human3.28299756
4STAT6_21828071_ChIP-Seq_BEAS2B_Human3.15486469
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.97397886
6KDM2B_26808549_Chip-Seq_SUP-B15_Human2.76927577
7KDM2B_26808549_Chip-Seq_DND41_Human2.75483408
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.64600048
9ZNF263_19887448_ChIP-Seq_K562_Human2.62369182
10TCF7_22412390_ChIP-Seq_EML_Mouse2.56785043
11* ELK3_25401928_ChIP-Seq_HUVEC_Human2.55760278
12KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.42582188
13VDR_21846776_ChIP-Seq_THP-1_Human2.40522005
14KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.11520308
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.11151398
16* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.08096975
17EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.07956382
18RACK7_27058665_Chip-Seq_MCF-7_Human2.07002355
19TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.02870358
20CLOCK_20551151_ChIP-Seq_293T_Human2.00387626
21KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.99543891
22TBX20_22328084_ChIP-Seq_HEART_Mouse1.96797159
23TBX20_22080862_ChIP-Seq_HEART_Mouse1.96797159
24* LXR_22292898_ChIP-Seq_THP-1_Human1.94887887
25* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.94294963
26ATF3_27146783_Chip-Seq_COLON_Human1.92337316
27KDM2B_26808549_Chip-Seq_JURKAT_Human1.85787833
28STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.84877648
29* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.82496364
30HIF1A_21447827_ChIP-Seq_MCF-7_Human1.79476569
31P300_27058665_Chip-Seq_ZR-75-30cells_Human1.76719531
32KDM2B_26808549_Chip-Seq_K562_Human1.74203020
33MAF_26560356_Chip-Seq_TH1_Human1.72375636
34* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.69451169
35TRIM28_21343339_ChIP-Seq_HEK293_Human1.68599461
36UTX_26944678_Chip-Seq_JUKART_Human1.67844627
37ZFP281_27345836_Chip-Seq_ESCs_Mouse1.66258534
38TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.65662099
39* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.65618678
40KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.62176373
41EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61763937
42EP300_21415370_ChIP-Seq_HL-1_Mouse1.60104157
43* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.59830199
44STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.59049492
45RUNX1_27514584_Chip-Seq_MCF-7_Human1.56660677
46ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.56627777
47* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.55438330
48SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.54512362
49ESR2_21235772_ChIP-Seq_MCF-7_Human1.52615719
50NCOR1_26117541_ChIP-Seq_K562_Human1.51117406
51UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.49883996
52TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.49706358
53CREB1_26743006_Chip-Seq_LNCaP_Human1.48575224
54PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.38548040
55VDR_24763502_ChIP-Seq_THP-1_Human1.36551692
56TP53_22127205_ChIP-Seq_IMR90_Human1.33926851
57* UBF1/2_26484160_Chip-Seq_HMECs_Human1.33020126
58RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30097075
59ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.27523096
60MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.27470895
61KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.26234004
62FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.24482610
63DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.23559902
64CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.23516620
65* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.23337371
66SOX9_24532713_ChIP-Seq_HFSC_Mouse1.21332919
67STAT3_1855785_ChIP-Seq_MESCs_Mouse1.20540079
68* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.20382605
69RUNX1_22412390_ChIP-Seq_EML_Mouse1.19866478
70ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.19345156
71FOXO3_23340844_ChIP-Seq_DLD1_Human1.19095656
72ERG_21242973_ChIP-ChIP_JURKAT_Human1.18227297
73CTCF_27219007_Chip-Seq_ERYTHROID_Human1.17747498
74TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.17603907
75NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.17591551
76TET1_21451524_ChIP-Seq_MESCs_Mouse1.17481692
77SRY_22984422_ChIP-ChIP_TESTIS_Rat1.17184032
78RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.16781628
79* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15877813
80E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.14973164
81TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13991109
82SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.13636790
83E2F7_22180533_ChIP-Seq_HELA_Human1.12156211
84* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.12092730
85MAF_26560356_Chip-Seq_TH2_Human1.11979004
86MYB_21317192_ChIP-Seq_ERMYB_Mouse1.11928000
87NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.11363387
88CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.10611931
89THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09030770
90MYC_19079543_ChIP-ChIP_MESCs_Mouse1.08726852
91ESR1_20079471_ChIP-ChIP_T-47D_Human1.08269808
92EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.08017993
93BRD4_27068464_Chip-Seq_AML-cells_Mouse1.07897047
94ISL1_27105846_Chip-Seq_CPCs_Mouse1.06853958
95NFIB_24661679_ChIP-Seq_LUNG_Mouse1.06794574
96GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06428323
97* P68_20966046_ChIP-Seq_HELA_Human1.05090052
98SA1_27219007_Chip-Seq_ERYTHROID_Human1.04852050
99VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04718549
100SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.03321730
101PPAR_26484153_Chip-Seq_NCI-H1993_Human1.02576588
102* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01855095
103SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00694553
104SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.99380697
105ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.99360064
106NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.99231873
107SPI1_23127762_ChIP-Seq_K562_Human0.98779952
108SMC1_22415368_ChIP-Seq_MEFs_Mouse0.98604556
109CHD1_26751641_Chip-Seq_LNCaP_Human0.98402745
110HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.98121132
111* TP63_22573176_ChIP-Seq_HFKS_Human0.97820393
112TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97411719
113SMC4_20622854_ChIP-Seq_HELA_Human0.97239331
114CIITA_25753668_ChIP-Seq_RAJI_Human0.97093241
115GATA6_25053715_ChIP-Seq_YYC3_Human0.96952828
116ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.96441436
117POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.96112312
118SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.96104404
119SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.96104404
120ESR1_21235772_ChIP-Seq_MCF-7_Human0.95329097
121KLF4_18555785_ChIP-Seq_MESCs_Mouse0.94863739
122GATA1_19941826_ChIP-Seq_K562_Human0.94482383
123SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.93395612
124HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93023585
125* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.92710868

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004084_abnormal_cardiac_muscle3.94976390
2MP0002837_dystrophic_cardiac_calcinosis3.60742100
3MP0000751_myopathy3.28704471
4MP0003705_abnormal_hypodermis_morpholog3.19851568
5MP0005330_cardiomyopathy2.65127853
6MP0003646_muscle_fatigue2.63524936
7MP0004036_abnormal_muscle_relaxation2.60986639
8* MP0004087_abnormal_muscle_fiber2.51825245
9MP0003566_abnormal_cell_adhesion2.49176149
10MP0005451_abnormal_body_composition2.44105482
11MP0000750_abnormal_muscle_regeneration2.40273763
12MP0003828_pulmonary_edema2.38966542
13* MP0010630_abnormal_cardiac_muscle2.33867359
14MP0000749_muscle_degeneration2.29643405
15MP0004215_abnormal_myocardial_fiber2.15306452
16MP0010352_gastrointestinal_tract_polyps2.06251207
17MP0008438_abnormal_cutaneous_collagen2.03290530
18MP0005623_abnormal_meninges_morphology2.02655389
19MP0005076_abnormal_cell_differentiation1.95988067
20MP0004185_abnormal_adipocyte_glucose1.93666057
21MP0002972_abnormal_cardiac_muscle1.92352146
22MP0004510_myositis1.89587870
23MP0002877_abnormal_melanocyte_morpholog1.88298180
24MP0006138_congestive_heart_failure1.86906580
25MP0009840_abnormal_foam_cell1.86674638
26MP0004858_abnormal_nervous_system1.85865538
27MP0003279_aneurysm1.83400195
28MP0008775_abnormal_heart_ventricle1.82734837
29MP0005385_cardiovascular_system_phenoty1.80156842
30MP0001544_abnormal_cardiovascular_syste1.80156842
31MP0002106_abnormal_muscle_physiology1.79354692
32MP0000733_abnormal_muscle_development1.79227202
33MP0005257_abnormal_intraocular_pressure1.71531302
34MP0003436_decreased_susceptibility_to1.70253812
35MP0005620_abnormal_muscle_contractility1.69689888
36MP0003137_abnormal_impulse_conducting1.62688055
37* MP0000759_abnormal_skeletal_muscle1.59807000
38MP0002269_muscular_atrophy1.59553719
39MP0003303_peritoneal_inflammation1.57663318
40MP0005058_abnormal_lysosome_morphology1.57211820
41MP0004272_abnormal_basement_membrane1.55085718
42MP0002254_reproductive_system_inflammat1.50921522
43MP0002796_impaired_skin_barrier1.47042108
44MP0003567_abnormal_fetal_cardiomyocyte1.45132012
45MP0005369_muscle_phenotype1.43423214
46MP0008961_abnormal_basal_metabolism1.42682056
47MP0009278_abnormal_bone_marrow1.41064157
48MP0004233_abnormal_muscle_weight1.40064371
49MP0002234_abnormal_pharynx_morphology1.39746077
50MP0004484_altered_response_of1.39248646
51MP0003300_gastrointestinal_ulcer1.36283337
52MP0005666_abnormal_adipose_tissue1.35927161
53MP0005275_abnormal_skin_tensile1.35765773
54MP0000858_altered_metastatic_potential1.34284853
55MP0003091_abnormal_cell_migration1.32652672
56* MP0000266_abnormal_heart_morphology1.32082603
57MP0004947_skin_inflammation1.30232723
58MP0004145_abnormal_muscle_electrophysio1.30149766
59MP0010030_abnormal_orbit_morphology1.27813468
60MP0005375_adipose_tissue_phenotype1.26720508
61* MP0002925_abnormal_cardiovascular_devel1.25777751
62MP0002998_abnormal_bone_remodeling1.25014178
63MP0000747_muscle_weakness1.24866007
64MP0005023_abnormal_wound_healing1.21350731
65MP0003950_abnormal_plasma_membrane1.17413708
66* MP0002088_abnormal_embryonic_growth/wei1.17082562
67* MP0003984_embryonic_growth_retardation1.16880930
68MP0002127_abnormal_cardiovascular_syste1.15869040
69MP0001849_ear_inflammation1.15532380
70MP0005409_darkened_coat_color1.15124607
71MP0004130_abnormal_muscle_cell1.13301231
72MP0000003_abnormal_adipose_tissue1.13007565
73MP0002089_abnormal_postnatal_growth/wei1.10985805
74* MP0004085_abnormal_heartbeat1.10905175
75MP0008260_abnormal_autophagy1.09635236
76* MP0000767_abnormal_smooth_muscle1.08028579
77* MP0003221_abnormal_cardiomyocyte_apopto1.07327971
78MP0001958_emphysema1.05773305
79* MP0001672_abnormal_embryogenesis/_devel1.04899370
80* MP0005380_embryogenesis_phenotype1.04899370
81MP0003172_abnormal_lysosome_physiology1.04573444
82MP0010368_abnormal_lymphatic_system1.03421328
83MP0003385_abnormal_body_wall1.02690653
84* MP0002128_abnormal_blood_circulation1.01778074
85MP0005503_abnormal_tendon_morphology1.01191816
86MP0000678_abnormal_parathyroid_gland1.01143466
87MP0000428_abnormal_craniofacial_morphol1.00645372
88MP0004197_abnormal_fetal_growth/weight/1.00419472
89MP0009333_abnormal_splenocyte_physiolog0.98979967
90* MP0009672_abnormal_birth_weight0.98332991
91MP0005501_abnormal_skin_physiology0.97993086
92MP0002086_abnormal_extraembryonic_tissu0.97859667
93MP0002396_abnormal_hematopoietic_system0.97204853
94MP0003115_abnormal_respiratory_system0.96081398
95MP0004808_abnormal_hematopoietic_stem0.94336719
96MP0001533_abnormal_skeleton_physiology0.92991778
97MP0002249_abnormal_larynx_morphology0.92954991
98MP0004264_abnormal_extraembryonic_tissu0.92766760
99MP0003941_abnormal_skin_development0.92451200
100MP0009053_abnormal_anal_canal0.91856441
101MP0005390_skeleton_phenotype0.90328199
102* MP0002084_abnormal_developmental_patter0.90065041
103* MP0001730_embryonic_growth_arrest0.89525102
104MP0005621_abnormal_cell_physiology0.87235108
105* MP0002085_abnormal_embryonic_tissue0.86952075
106MP0003763_abnormal_thymus_physiology0.86247483
107* MP0001697_abnormal_embryo_size0.86217376
108* MP0001784_abnormal_fluid_regulation0.85786039
109MP0000685_abnormal_immune_system0.85212705
110MP0000537_abnormal_urethra_morphology0.84531225
111* MP0001614_abnormal_blood_vessel0.84242776
112MP0003935_abnormal_craniofacial_develop0.82747878
113MP0010234_abnormal_vibrissa_follicle0.82695275
114MP0003191_abnormal_cellular_cholesterol0.82114196
115MP0002060_abnormal_skin_morphology0.81952102
116MP0003045_fibrosis0.79093274
117MP0000462_abnormal_digestive_system0.79053954
118MP0010307_abnormal_tumor_latency0.75973665
119MP0009384_cardiac_valve_regurgitation0.75852357
120MP0003119_abnormal_digestive_system0.75555492
121MP0000013_abnormal_adipose_tissue0.75143745
122MP0005508_abnormal_skeleton_morphology0.74781907
123MP0003448_altered_tumor_morphology0.74142826
124MP0001851_eye_inflammation0.73566799
125MP0000350_abnormal_cell_proliferation0.73004433
126MP0006054_spinal_hemorrhage0.72029141
127MP0009931_abnormal_skin_appearance0.71312075
128* MP0002080_prenatal_lethality0.70710558
129MP0000534_abnormal_ureter_morphology0.69848030
130MP0002108_abnormal_muscle_morphology0.69420490
131MP0003453_abnormal_keratinocyte_physiol0.69085997
132MP0001348_abnormal_lacrimal_gland0.67746205
133MP0003283_abnormal_digestive_organ0.60007691
134MP0000343_altered_response_to0.59278186
135MP0002896_abnormal_bone_mineralization0.58320785

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)5.52434612
2Ventricular tachycardia (HP:0004756)4.77588620
3Increased connective tissue (HP:0009025)4.30363015
4Muscle fiber splitting (HP:0003555)4.21698253
5Abnormality of the left ventricular outflow tract (HP:0011103)4.20017142
6Subaortic stenosis (HP:0001682)4.20017142
7Right ventricular cardiomyopathy (HP:0011663)4.16824741
8Hyporeflexia of lower limbs (HP:0002600)4.04032620
9Premature rupture of membranes (HP:0001788)3.63684264
10Protrusio acetabuli (HP:0003179)3.63349406
11Atrial fibrillation (HP:0005110)3.63144639
12Exercise-induced muscle cramps (HP:0003710)3.59596821
13Lipoatrophy (HP:0100578)3.51528768
14Cerebral aneurysm (HP:0004944)3.50987312
15Primary atrial arrhythmia (HP:0001692)3.49806403
16Difficulty climbing stairs (HP:0003551)3.48356380
17Exercise-induced myalgia (HP:0003738)3.44877472
18Abnormality of the calf musculature (HP:0001430)3.44203605
19Calf muscle hypertrophy (HP:0008981)3.41612352
20Supraventricular arrhythmia (HP:0005115)3.38924548
21Supraventricular tachycardia (HP:0004755)3.36590814
22Shallow orbits (HP:0000586)3.08778369
23EMG: myopathic abnormalities (HP:0003458)3.05319974
24Muscle hypertrophy of the lower extremities (HP:0008968)3.04068300
25Type 1 muscle fiber predominance (HP:0003803)3.00520971
26Mildly elevated creatine phosphokinase (HP:0008180)2.99287207
27Difficulty running (HP:0009046)2.98908605
28Distal lower limb amyotrophy (HP:0008944)2.95386231
29Asymmetric septal hypertrophy (HP:0001670)2.93066214
30Bundle branch block (HP:0011710)2.80813962
31Broad face (HP:0000283)2.80226459
32Ventricular arrhythmia (HP:0004308)2.70595503
33Syncope (HP:0001279)2.62522335
34Dilated cardiomyopathy (HP:0001644)2.61098301
35Prolonged QT interval (HP:0001657)2.58958709
36Ankle contracture (HP:0006466)2.54838492
37Ventricular fibrillation (HP:0001663)2.52213755
38Atrioventricular block (HP:0001678)2.48502539
39Abnormal atrioventricular conduction (HP:0005150)2.46231864
40Increased density of long bones (HP:0006392)2.45152500
41Scapular winging (HP:0003691)2.44773477
42Myoglobinuria (HP:0002913)2.43546879
43Increased variability in muscle fiber diameter (HP:0003557)2.39412146
44Obstructive sleep apnea (HP:0002870)2.37419523
45Myopathic facies (HP:0002058)2.34673452
46Atrophic scars (HP:0001075)2.32704662
47Aneurysm (HP:0002617)2.32004265
48Abnormality of skeletal muscle fiber size (HP:0012084)2.31001909
49Lower limb amyotrophy (HP:0007210)2.30406747
50Broad metatarsal (HP:0001783)2.28971076
51Heart block (HP:0012722)2.28822074
52Limb-girdle muscle atrophy (HP:0003797)2.23787788
53Aortic aneurysm (HP:0004942)2.21203260
54Aortic dissection (HP:0002647)2.21078773
55Hyperacusis (HP:0010780)2.20793329
56Distal lower limb muscle weakness (HP:0009053)2.19203525
57Nemaline bodies (HP:0003798)2.18007536
58Mitral valve prolapse (HP:0001634)2.17783489
59Bladder diverticulum (HP:0000015)2.17115007
60Long palpebral fissure (HP:0000637)2.16851019
61Abnormality of the distal phalanx of the thumb (HP:0009617)2.16232053
62Vertebral compression fractures (HP:0002953)2.10818183
63Dilatation of the ascending aorta (HP:0005111)2.09582679
64Spinal rigidity (HP:0003306)2.09549238
65Round ear (HP:0100830)2.09250003
66Achilles tendon contracture (HP:0001771)2.09036584
67Milia (HP:0001056)2.08064480
68Genu recurvatum (HP:0002816)2.06926531
69Generalized amyotrophy (HP:0003700)2.06169161
70Rectal prolapse (HP:0002035)2.05700789
71Ulnar bowing (HP:0003031)2.03309103
72Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.02213094
73Short 4th metacarpal (HP:0010044)2.02213094
74Fragile skin (HP:0001030)2.01257375
75Blue sclerae (HP:0000592)2.00914681
76Asymmetry of the thorax (HP:0001555)1.97052061
77Trismus (HP:0000211)1.95465937
78EMG: neuropathic changes (HP:0003445)1.93465645
79Bicuspid aortic valve (HP:0001647)1.92010705
80Myotonia (HP:0002486)1.90065922
81Osteolytic defects of the hand bones (HP:0009699)1.89964343
82Osteolytic defects of the phalanges of the hand (HP:0009771)1.89964343
83Ulnar deviation of the wrist (HP:0003049)1.87428176
84Rhabdomyolysis (HP:0003201)1.86116134
85Cellulitis (HP:0100658)1.86039714
86Abnormality of the tricuspid valve (HP:0001702)1.84084004
87Dysmetric saccades (HP:0000641)1.84005332
88Segmental peripheral demyelination/remyelination (HP:0003481)1.83940817
89Lymphangioma (HP:0100764)1.83867085
90Emphysema (HP:0002097)1.83066874
91Neck muscle weakness (HP:0000467)1.83046775
92Abnormality of the 4th metacarpal (HP:0010012)1.82927295
93Thin ribs (HP:0000883)1.82819184
94Progressive muscle weakness (HP:0003323)1.82534936
95Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.81813768
96Bulbar palsy (HP:0001283)1.81472226
97Spinal cord lesions (HP:0100561)1.80722145
98Syringomyelia (HP:0003396)1.80722145
99Short nail (HP:0001799)1.80268399
100Cervical subluxation (HP:0003308)1.78902563
101Arterial tortuosity (HP:0005116)1.78196481
102Vascular tortuosity (HP:0004948)1.77803892
103Slender build (HP:0001533)1.76460792
104Dislocated radial head (HP:0003083)1.76292324
105Wormian bones (HP:0002645)1.75528185
106Muscle fiber inclusion bodies (HP:0100299)1.75018375
107Biconcave vertebral bodies (HP:0004586)1.74601351
108Palpitations (HP:0001962)1.74511050
109Testicular atrophy (HP:0000029)1.74308433
110Mitral regurgitation (HP:0001653)1.73394573
111Sudden cardiac death (HP:0001645)1.72569677
112Distal upper limb amyotrophy (HP:0007149)1.72260314
113Upper limb amyotrophy (HP:0009129)1.72260314
114Abnormality of the Achilles tendon (HP:0005109)1.69579664
115Advanced eruption of teeth (HP:0006288)1.69493641
116Renal duplication (HP:0000075)1.67561872
117Persistence of primary teeth (HP:0006335)1.67424900
118Arnold-Chiari malformation (HP:0002308)1.66661133
119Natal tooth (HP:0000695)1.66647895
120Wrist flexion contracture (HP:0001239)1.66448866
121Hypoplastic ischia (HP:0003175)1.65250362
122Hyperparathyroidism (HP:0000843)1.64991173
123Flat acetabular roof (HP:0003180)1.64733753
124Centrally nucleated skeletal muscle fibers (HP:0003687)1.63513839
125Hyperextensible skin (HP:0000974)1.63451565
126Abnormal ossification of hand bones (HP:0005921)1.63405974
127Frequent falls (HP:0002359)1.63024517
128Stridor (HP:0010307)1.62960065
129Turricephaly (HP:0000262)1.62418476
130Abnormality of the radial head (HP:0003995)1.61595085
131Limb-girdle muscle weakness (HP:0003325)1.61506885
132Palmoplantar keratoderma (HP:0000982)1.61266291
133Large for gestational age (HP:0001520)1.59597048
134Camptodactyly of toe (HP:0001836)1.59382531
135Abnormality of the fingertips (HP:0001211)1.59177666
136Thin bony cortex (HP:0002753)1.59090168
137Abnormal EKG (HP:0003115)1.57236765
138Selective tooth agenesis (HP:0001592)1.56848570
139Abnormality of the thoracic spine (HP:0100711)1.56787288
140Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.56600771
141Joint laxity (HP:0001388)1.56390235
142Disproportionate tall stature (HP:0001519)1.56263833
143Easy fatigability (HP:0003388)1.55838215
144Abnormality of oral frenula (HP:0000190)1.55422469
145Calcaneovalgus deformity (HP:0001848)1.54998398
146Broad distal phalanx of finger (HP:0009836)1.54862227
147Spondylolisthesis (HP:0003302)1.54458552
148Long eyelashes (HP:0000527)1.54390499
149Abnormality of the calcaneus (HP:0008364)1.53146356
150Abnormality of the foot musculature (HP:0001436)1.51287345

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.43754654
2TTN4.97636390
3PKN24.36416651
4PRPF4B3.81953708
5SMG13.31611268
6EEF2K3.18309641
7MAP3K102.91323235
8IRAK32.18345408
9RIPK12.18019965
10CDK122.10367728
11PDGFRA1.87802838
12ICK1.73902142
13TAOK21.70661220
14PTK61.60921679
15EPHA21.55241889
16* DMPK1.52086542
17NME21.44435302
18TAOK11.42878695
19LMTK21.42773032
20EPHB11.39779591
21ILK1.37119694
22ERN11.35510018
23MAP4K11.32071294
24BMX1.31741786
25STK241.29095381
26MTOR1.28997464
27PRKD31.28912745
28STK101.28769921
29MYLK1.28752612
30LRRK21.27685628
31OBSCN1.27471590
32PHKG21.26854068
33PHKG11.26854068
34SIK11.24520026
35ALK1.24154022
36MAP3K131.23837997
37PAK21.20655432
38LATS11.19412504
39MAP3K31.18096948
40KSR21.17466580
41MAP3K71.14515043
42MAP2K31.14212860
43CDC42BPA1.12404603
44LATS21.10770781
45TRPM71.06300868
46PRKD11.05263837
47DDR20.98825813
48TYRO30.93656777
49RPS6KB20.92627110
50PRKD20.92212035
51RIPK40.89711715
52MAP3K140.87563639
53MAP3K90.83092002
54STK30.81634038
55PTK20.81254136
56PAK40.81142392
57IRAK40.80046244
58NEK10.79596067
59MAPKAPK30.79427949
60PAK30.75721121
61PDGFRB0.75650748
62CDK40.74986428
63MAPK150.74935183
64MAPK120.74726000
65ARAF0.74663572
66TGFBR20.73823372
67RPS6KA40.73072782
68MAP3K60.72229542
69PDPK10.71562879
70IRAK20.70816894
71MARK20.69975037
72PTK2B0.68973949
73SIK30.68856107
74NEK20.68002640
75MAPK70.66480519
76MOS0.66113323
77ROCK10.65912226
78MAP3K110.64264359
79TYK20.62736313
80RET0.62350623
81* RPS6KL10.62298866
82SIK20.62208404
83TGFBR10.59779055
84PDK30.58736394
85PDK40.58736394
86HIPK20.58330173
87MAP3K80.57930245
88BRAF0.57356221
89* RPS6KA20.57326655
90PIK3CA0.56555892
91FER0.56019953
92FLT30.55420285
93CDK70.54544199
94EPHB20.54461455
95FGFR40.52729621
96* RPS6KA10.51905035
97BRD40.51498959
98PRKCH0.50555786
99PASK0.49136156
100CAMK1G0.48858852
101PRKG20.48699985
102MAPK110.48685595
103NEK90.47559512
104CSK0.46921778
105STK40.46883102
106GRK60.46381341
107DAPK30.44662328
108HCK0.43510012
109MAP3K50.43435532
110PRKAA20.42843241
111MAPK40.42380500
112ROCK20.41664141
113CAMK40.41192220
114EPHA30.40481687
115CDK60.40214703
116CHUK0.40025064
117MELK0.39717641
118MAP3K10.39278695
119TESK10.39176143
120FGFR10.38476603
121STK110.38193641
122MAP2K20.38168121
123SGK30.38149041
124CAMK1D0.37909399
125NTRK10.37777144
126TBK10.37718337
127FGFR30.37460499
128MARK30.37176384
129* RPS6KA60.36861364
130ZAP700.36607853
131PRKAA10.36205563
132DYRK1B0.36139957
133AKT20.35431533
134PDK10.35193480
135JAK30.34525196
136* RPS6KC10.34261972
137STK380.31540272

Predicted pathways (KEGG)

RankGene SetZ-score
1Dilated cardiomyopathy_Homo sapiens_hsa054143.04051340
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.93766715
3Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.40927639
4Viral myocarditis_Homo sapiens_hsa054162.16506432
5Focal adhesion_Homo sapiens_hsa045102.00938874
6Adherens junction_Homo sapiens_hsa045201.81325709
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.75008711
8Chronic myeloid leukemia_Homo sapiens_hsa052201.74101406
9Cardiac muscle contraction_Homo sapiens_hsa042601.61401379
10ECM-receptor interaction_Homo sapiens_hsa045121.60871350
11Small cell lung cancer_Homo sapiens_hsa052221.60062530
12Proteoglycans in cancer_Homo sapiens_hsa052051.58729080
13AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.55511925
14Prion diseases_Homo sapiens_hsa050201.51325734
15VEGF signaling pathway_Homo sapiens_hsa043701.49903191
16Other glycan degradation_Homo sapiens_hsa005111.48654448
17Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.48234316
18Insulin resistance_Homo sapiens_hsa049311.38556524
19Notch signaling pathway_Homo sapiens_hsa043301.37259494
20Thyroid hormone signaling pathway_Homo sapiens_hsa049191.36630690
21Tight junction_Homo sapiens_hsa045301.36193207
22Amoebiasis_Homo sapiens_hsa051461.35403399
23Acute myeloid leukemia_Homo sapiens_hsa052211.34609807
24Leukocyte transendothelial migration_Homo sapiens_hsa046701.33901039
25Renal cell carcinoma_Homo sapiens_hsa052111.33414365
26MicroRNAs in cancer_Homo sapiens_hsa052061.33334099
27Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.30634616
28mTOR signaling pathway_Homo sapiens_hsa041501.29859516
29Hippo signaling pathway_Homo sapiens_hsa043901.29139110
30Central carbon metabolism in cancer_Homo sapiens_hsa052301.27754036
31Bladder cancer_Homo sapiens_hsa052191.26797998
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.25788890
33Lysine degradation_Homo sapiens_hsa003101.24074403
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.22412152
35Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.21986570
36Regulation of actin cytoskeleton_Homo sapiens_hsa048101.21530303
37HIF-1 signaling pathway_Homo sapiens_hsa040661.21079296
38Toxoplasmosis_Homo sapiens_hsa051451.18182984
39Pentose phosphate pathway_Homo sapiens_hsa000301.15061776
40Insulin signaling pathway_Homo sapiens_hsa049101.14288960
41Endometrial cancer_Homo sapiens_hsa052131.13740580
42* HTLV-I infection_Homo sapiens_hsa051661.12720546
43Non-small cell lung cancer_Homo sapiens_hsa052231.11801237
44Longevity regulating pathway - mammal_Homo sapiens_hsa042111.09224471
45Basal cell carcinoma_Homo sapiens_hsa052171.07411751
46Hepatitis C_Homo sapiens_hsa051601.05498321
47Estrogen signaling pathway_Homo sapiens_hsa049151.04756158
48Dorso-ventral axis formation_Homo sapiens_hsa043201.04620868
49B cell receptor signaling pathway_Homo sapiens_hsa046621.04614413
50Neurotrophin signaling pathway_Homo sapiens_hsa047221.04038747
51* cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02974872
52Platelet activation_Homo sapiens_hsa046111.02715666
53Adipocytokine signaling pathway_Homo sapiens_hsa049201.02575844
54Glioma_Homo sapiens_hsa052141.01819657
55Influenza A_Homo sapiens_hsa051641.00379330
56Osteoclast differentiation_Homo sapiens_hsa043800.97784442
57Pancreatic cancer_Homo sapiens_hsa052120.97437712
58Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.95116547
59AMPK signaling pathway_Homo sapiens_hsa041520.94577384
60Glucagon signaling pathway_Homo sapiens_hsa049220.93178641
61Colorectal cancer_Homo sapiens_hsa052100.92619950
62Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.91157121
63Type II diabetes mellitus_Homo sapiens_hsa049300.91152671
64NF-kappa B signaling pathway_Homo sapiens_hsa040640.90800060
65Fructose and mannose metabolism_Homo sapiens_hsa000510.90382605
66Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89813329
67TGF-beta signaling pathway_Homo sapiens_hsa043500.88826281
68Prolactin signaling pathway_Homo sapiens_hsa049170.86237789
69Pathways in cancer_Homo sapiens_hsa052000.85942550
70Thyroid cancer_Homo sapiens_hsa052160.84356790
71T cell receptor signaling pathway_Homo sapiens_hsa046600.84128244
72* MAPK signaling pathway_Homo sapiens_hsa040100.83644542
73Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83075412
74Rap1 signaling pathway_Homo sapiens_hsa040150.82712072
75Hedgehog signaling pathway_Homo sapiens_hsa043400.82665661
76Prostate cancer_Homo sapiens_hsa052150.81547993
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77398490
78FoxO signaling pathway_Homo sapiens_hsa040680.76346981
79mRNA surveillance pathway_Homo sapiens_hsa030150.76182181
80Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76067967
81Measles_Homo sapiens_hsa051620.75937763
82Oxytocin signaling pathway_Homo sapiens_hsa049210.75861258
83GnRH signaling pathway_Homo sapiens_hsa049120.75330554
84Apoptosis_Homo sapiens_hsa042100.75033453
85Wnt signaling pathway_Homo sapiens_hsa043100.74998437
86Hepatitis B_Homo sapiens_hsa051610.74488040
87Herpes simplex infection_Homo sapiens_hsa051680.73678195
88Malaria_Homo sapiens_hsa051440.72513801
89Galactose metabolism_Homo sapiens_hsa000520.71430591
90ErbB signaling pathway_Homo sapiens_hsa040120.71412884
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.71312899
92Epstein-Barr virus infection_Homo sapiens_hsa051690.69697780
93Leishmaniasis_Homo sapiens_hsa051400.69515999
94PI3K-Akt signaling pathway_Homo sapiens_hsa041510.68977252
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.67793607
96Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67212924
97* Viral carcinogenesis_Homo sapiens_hsa052030.67105828
98Melanogenesis_Homo sapiens_hsa049160.66322233
99TNF signaling pathway_Homo sapiens_hsa046680.65729616
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.65388029
101Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.65288065
102Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63982026
103Shigellosis_Homo sapiens_hsa051310.63906405
104Inositol phosphate metabolism_Homo sapiens_hsa005620.63122329
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.61085985
106Chemokine signaling pathway_Homo sapiens_hsa040620.60570711
107Salmonella infection_Homo sapiens_hsa051320.60445417
108Tuberculosis_Homo sapiens_hsa051520.59370207
109Gap junction_Homo sapiens_hsa045400.58324828
110Biosynthesis of amino acids_Homo sapiens_hsa012300.58157371
111Melanoma_Homo sapiens_hsa052180.56491995
112Choline metabolism in cancer_Homo sapiens_hsa052310.56047985
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54695872
114Pertussis_Homo sapiens_hsa051330.54312748
115Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53975154
116Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53350393
117Long-term potentiation_Homo sapiens_hsa047200.52671346
118Protein digestion and absorption_Homo sapiens_hsa049740.51239753
119Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.51155776
120Endocytosis_Homo sapiens_hsa041440.50680165
121Antigen processing and presentation_Homo sapiens_hsa046120.49968340
122Jak-STAT signaling pathway_Homo sapiens_hsa046300.49686798
123Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48485545

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