SREK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of serine/arginine-rich (SR) splicing proteins containing RNA recognition motif (RRM) domains. The encoded protein interacts with other SR proteins to modulate splice site selection. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1replication fork processing (GO:0031297)4.51087660
2histone H3-K4 trimethylation (GO:0080182)4.25451360
3monoubiquitinated protein deubiquitination (GO:0035520)4.22495669
4kinetochore organization (GO:0051383)4.00276534
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.86692579
6regulation of centriole replication (GO:0046599)3.70098722
7mesenchymal cell differentiation involved in kidney development (GO:0072161)3.67333773
8mesenchymal cell differentiation involved in renal system development (GO:2001012)3.67333773
9intraciliary transport (GO:0042073)3.55096820
10maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.53314750
11resolution of meiotic recombination intermediates (GO:0000712)3.47347900
12microtubule anchoring (GO:0034453)3.45979322
13presynaptic membrane assembly (GO:0097105)3.44792838
14regulation of nuclear cell cycle DNA replication (GO:0033262)3.43579450
15negative regulation of DNA-dependent DNA replication (GO:2000104)3.33385603
16limb bud formation (GO:0060174)3.32522852
17epithelial cilium movement (GO:0003351)3.29526461
18poly(A)+ mRNA export from nucleus (GO:0016973)3.26524888
19centriole replication (GO:0007099)3.24993231
20kinetochore assembly (GO:0051382)3.20879304
21regulation of centrosome duplication (GO:0010824)3.14190662
22somite development (GO:0061053)3.08748440
23mitotic sister chromatid cohesion (GO:0007064)3.07751779
24cell differentiation involved in metanephros development (GO:0072202)3.06244972
25cilium movement (GO:0003341)3.05299960
26double-strand break repair via homologous recombination (GO:0000724)3.01101411
27sister chromatid cohesion (GO:0007062)2.99932934
28recombinational repair (GO:0000725)2.99886304
29nucleotide transmembrane transport (GO:1901679)2.99778083
30cerebral cortex radially oriented cell migration (GO:0021799)2.98184503
31mRNA splice site selection (GO:0006376)2.96450686
32mesenchymal cell differentiation (GO:0048762)2.95425990
33centriole assembly (GO:0098534)2.94936367
34cell differentiation involved in kidney development (GO:0061005)2.94434811
35presynaptic membrane organization (GO:0097090)2.91403640
36sister chromatid segregation (GO:0000819)2.89093587
37negative regulation of keratinocyte proliferation (GO:0010839)2.88856330
38nonmotile primary cilium assembly (GO:0035058)2.86737995
39prenylation (GO:0097354)2.86409426
40protein prenylation (GO:0018342)2.86409426
41peptidyl-lysine methylation (GO:0018022)2.85968467
42microtubule organizing center organization (GO:0031023)2.85924354
43DNA ligation (GO:0006266)2.85542344
44protein K11-linked deubiquitination (GO:0035871)2.85348810
45peptidyl-lysine trimethylation (GO:0018023)2.84766968
46regulation of non-canonical Wnt signaling pathway (GO:2000050)2.82924195
47centrosome organization (GO:0051297)2.82790822
48regulation of centrosome cycle (GO:0046605)2.81920415
49regulation of pigment cell differentiation (GO:0050932)2.81566649
50axoneme assembly (GO:0035082)2.80860984
51replicative senescence (GO:0090399)2.80770045
52regulation of DNA endoreduplication (GO:0032875)2.80701598
53retina layer formation (GO:0010842)2.80582621
54detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.79598282
55histone H3-K4 methylation (GO:0051568)2.74965139
56attachment of spindle microtubules to kinetochore (GO:0008608)2.74485556
57negative regulation of stem cell proliferation (GO:2000647)2.74025462
58protein K6-linked ubiquitination (GO:0085020)2.72897015
59intra-S DNA damage checkpoint (GO:0031573)2.72223266
60rRNA catabolic process (GO:0016075)2.69425468
61DNA replication checkpoint (GO:0000076)2.68753501
62synapsis (GO:0007129)2.66360469
63cytoplasmic mRNA processing body assembly (GO:0033962)2.65557947
64negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.64445469
65negative regulation of translation, ncRNA-mediated (GO:0040033)2.64445469
66regulation of translation, ncRNA-mediated (GO:0045974)2.64445469
67startle response (GO:0001964)2.64227045
68prostate gland growth (GO:0060736)2.62048153
69DNA strand renaturation (GO:0000733)2.61917686
70metanephric mesenchyme development (GO:0072075)2.58443915
71spinal cord motor neuron differentiation (GO:0021522)2.58219632
72kidney morphogenesis (GO:0060993)2.57934155
73developmental pigmentation (GO:0048066)2.57844753
74mitotic sister chromatid segregation (GO:0000070)2.57143138
75histone H3-K9 modification (GO:0061647)2.55934423
76negative regulation of myoblast differentiation (GO:0045662)2.55060456
77nuclear pore complex assembly (GO:0051292)2.54833282
78negative regulation of neurotransmitter secretion (GO:0046929)2.54760402
79otic vesicle formation (GO:0030916)2.54417935
80L-fucose catabolic process (GO:0042355)2.54162043
81fucose catabolic process (GO:0019317)2.54162043
82L-fucose metabolic process (GO:0042354)2.54162043
83cell proliferation involved in kidney development (GO:0072111)2.53948970
84cilium or flagellum-dependent cell motility (GO:0001539)2.52990931
85reciprocal meiotic recombination (GO:0007131)2.52926254
86reciprocal DNA recombination (GO:0035825)2.52926254
87behavioral response to nicotine (GO:0035095)2.52757671
88dentate gyrus development (GO:0021542)2.52256058
89chromatin remodeling at centromere (GO:0031055)2.51947280
90cell proliferation in forebrain (GO:0021846)2.50764422
91regulation of mRNA splicing, via spliceosome (GO:0048024)2.50333046
92regulation of meiosis I (GO:0060631)2.48838697
93regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.46916765
94regulation of mitotic spindle checkpoint (GO:1903504)2.46916765
95cilium morphogenesis (GO:0060271)2.46485222
96negative regulation of DNA recombination (GO:0045910)2.45546200
97DNA topological change (GO:0006265)2.45092320
98positive regulation of histone H3-K4 methylation (GO:0051571)2.44150677
99nucleus localization (GO:0051647)2.43261998
100nuclear pore organization (GO:0006999)2.43060073
101kidney mesenchyme development (GO:0072074)2.42861682
102regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.42789227
103positive regulation of developmental pigmentation (GO:0048087)2.42264085
104postsynaptic membrane organization (GO:0001941)2.41869196
105sympathetic nervous system development (GO:0048485)2.41359203
106snRNA transcription (GO:0009301)2.41241809
107DNA double-strand break processing (GO:0000729)2.40959578
108mechanosensory behavior (GO:0007638)2.40391475
109regulation of telomere maintenance (GO:0032204)2.40332040
110establishment of protein localization to Golgi (GO:0072600)2.40212973
111interkinetic nuclear migration (GO:0022027)2.40140270
112regulation of cell proliferation involved in kidney development (GO:1901722)2.38875842
113glomerulus development (GO:0032835)2.37193324
114translesion synthesis (GO:0019985)2.36733317
115embryonic digit morphogenesis (GO:0042733)2.36697483
116histone H3-K9 methylation (GO:0051567)2.35357259
117histone H2B ubiquitination (GO:0033523)2.35030031
118cilium assembly (GO:0042384)2.33257151
119positive regulation of DNA-dependent DNA replication (GO:2000105)2.32909371
120cornea development in camera-type eye (GO:0061303)2.32706300
121ER overload response (GO:0006983)2.32424311
122centrosome duplication (GO:0051298)2.32055000
123histone lysine methylation (GO:0034968)2.31396985
124limb development (GO:0060173)2.31318572
125appendage development (GO:0048736)2.31318572
126regulation of cilium movement (GO:0003352)2.29870954
127negative regulation of astrocyte differentiation (GO:0048712)2.29860334
128mesonephros development (GO:0001823)2.29199890
129postreplication repair (GO:0006301)2.28299433
130axonemal dynein complex assembly (GO:0070286)2.28218228
131regulation of male gonad development (GO:2000018)2.27564783
132photoreceptor cell maintenance (GO:0045494)2.27456061
133histone exchange (GO:0043486)2.27226017
134pharyngeal system development (GO:0060037)2.27093209
135negative regulation of neurotransmitter transport (GO:0051589)2.26789754
136positive regulation of mRNA processing (GO:0050685)2.26589815
137lateral sprouting from an epithelium (GO:0060601)2.26409456
138female gonad development (GO:0008585)2.26068184
139cilium organization (GO:0044782)2.25429966
140definitive hemopoiesis (GO:0060216)2.25166417
141cranial nerve structural organization (GO:0021604)2.25104026
142neuron cell-cell adhesion (GO:0007158)2.25002002
143negative regulation of smooth muscle cell differentiation (GO:0051151)2.24811011
144CENP-A containing nucleosome assembly (GO:0034080)2.24810568
145somatic hypermutation of immunoglobulin genes (GO:0016446)2.24529974
146somatic diversification of immune receptors via somatic mutation (GO:0002566)2.24529974
147regulation of mRNA processing (GO:0050684)2.24226548
148regulation of timing of cell differentiation (GO:0048505)2.24017017
149histone H2A acetylation (GO:0043968)2.21789210
150neural tube formation (GO:0001841)2.20976248
151positive regulation of meiosis (GO:0045836)2.20624220
152telomere maintenance via telomerase (GO:0007004)2.19127663
153response to X-ray (GO:0010165)2.19071095
154righting reflex (GO:0060013)2.18809454
155microtubule depolymerization (GO:0007019)2.16550540
156regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.15322695
157regulation of somitogenesis (GO:0014807)2.15300811
158regulation of DNA-templated transcription, initiation (GO:2000142)2.15069241
159RNA-dependent DNA replication (GO:0006278)2.14498123
160regulation of keratinocyte proliferation (GO:0010837)2.14330338
161regulation of glomerulus development (GO:0090192)2.13843714
162cell differentiation in spinal cord (GO:0021515)2.12776175
163smoothened signaling pathway (GO:0007224)2.12536537
164meiotic chromosome segregation (GO:0045132)2.11850851
165facial nerve structural organization (GO:0021612)2.11559694
166inner ear receptor stereocilium organization (GO:0060122)2.10777239
167ganglion development (GO:0061548)2.10478296

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.67515322
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.20460338
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.85780972
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.68214484
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.64782396
6ZNF274_21170338_ChIP-Seq_K562_Hela2.63315748
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.36072594
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.34432305
9TAF15_26573619_Chip-Seq_HEK293_Human2.33421528
10FUS_26573619_Chip-Seq_HEK293_Human2.33147141
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.17853543
12EWS_26573619_Chip-Seq_HEK293_Human2.16475969
13EZH2_22144423_ChIP-Seq_EOC_Human2.14082916
14TP63_19390658_ChIP-ChIP_HaCaT_Human2.14078918
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.11449793
16PCGF2_27294783_Chip-Seq_ESCs_Mouse2.09236346
17SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.08785494
18BMI1_23680149_ChIP-Seq_NPCS_Mouse2.04173395
19PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.97561927
20IGF1R_20145208_ChIP-Seq_DFB_Human1.96129268
21SALL1_21062744_ChIP-ChIP_HESCs_Human1.93977589
22P300_19829295_ChIP-Seq_ESCs_Human1.93713112
23RBPJ_22232070_ChIP-Seq_NCS_Mouse1.90520630
24CBX2_27304074_Chip-Seq_ESCs_Mouse1.83039925
25TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.78814977
26SUZ12_27294783_Chip-Seq_NPCs_Mouse1.77925148
27POU5F1_16153702_ChIP-ChIP_HESCs_Human1.77360950
28NANOG_18555785_Chip-Seq_ESCs_Mouse1.77035110
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.72353951
30PCGF2_27294783_Chip-Seq_NPCs_Mouse1.71529073
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.71341547
32EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.68526749
33RNF2_27304074_Chip-Seq_NSC_Mouse1.68365535
34SMAD3_21741376_ChIP-Seq_EPCs_Human1.67679372
35NFE2_27457419_Chip-Seq_LIVER_Mouse1.65632026
36SMAD4_21799915_ChIP-Seq_A2780_Human1.65432210
37E2F1_18555785_Chip-Seq_ESCs_Mouse1.64841253
38FOXM1_23109430_ChIP-Seq_U2OS_Human1.64511131
39EZH2_27304074_Chip-Seq_ESCs_Mouse1.63320883
40ER_23166858_ChIP-Seq_MCF-7_Human1.62137011
41ELK1_19687146_ChIP-ChIP_HELA_Human1.60359823
42MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.59408589
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.58765817
44AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.58488203
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.58444024
46P53_22387025_ChIP-Seq_ESCs_Mouse1.58420271
47EED_16625203_ChIP-ChIP_MESCs_Mouse1.58052707
48CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.57142401
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55855822
50EZH2_27294783_Chip-Seq_NPCs_Mouse1.55526799
51SUZ12_18555785_Chip-Seq_ESCs_Mouse1.54171220
52VDR_22108803_ChIP-Seq_LS180_Human1.54100955
53* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53859303
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.52021239
55JARID2_20064375_ChIP-Seq_MESCs_Mouse1.50965644
56STAT3_23295773_ChIP-Seq_U87_Human1.49528284
57SMAD_19615063_ChIP-ChIP_OVARY_Human1.48679627
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.48479739
59CBP_20019798_ChIP-Seq_JUKART_Human1.48479739
60CMYC_18555785_Chip-Seq_ESCs_Mouse1.44264093
61STAT3_18555785_Chip-Seq_ESCs_Mouse1.43241101
62TCF4_23295773_ChIP-Seq_U87_Human1.42973943
63TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42626394
64RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.42263994
65P300_18555785_Chip-Seq_ESCs_Mouse1.41373029
66CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40370734
67HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.40353817
68PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.40195380
69KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.40156905
70EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.40029245
71PADI4_21655091_ChIP-ChIP_MCF-7_Human1.39576778
72* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38379569
73NOTCH1_21737748_ChIP-Seq_TLL_Human1.37676453
74SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.37364337
75ZNF217_24962896_ChIP-Seq_MCF-7_Human1.36195756
76BCAT_22108803_ChIP-Seq_LS180_Human1.36010830
77NMYC_18555785_Chip-Seq_ESCs_Mouse1.34918740
78NR3C1_21868756_ChIP-Seq_MCF10A_Human1.34571256
79E2F7_22180533_ChIP-Seq_HELA_Human1.33552131
80RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33085002
81AR_21572438_ChIP-Seq_LNCaP_Human1.33031019
82EST1_17652178_ChIP-ChIP_JURKAT_Human1.32032898
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.31483687
84TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31483687
85SOX2_18555785_Chip-Seq_ESCs_Mouse1.30476072
86AR_25329375_ChIP-Seq_VCAP_Human1.29685202
87SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29416855
88FOXM1_26456572_ChIP-Seq_MCF-7_Human1.29223957
89SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.28255480
90SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.28009582
91OCT4_18555785_Chip-Seq_ESCs_Mouse1.27340572
92IRF1_19129219_ChIP-ChIP_H3396_Human1.26993792
93PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26035205
94MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25564917
95MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.25538555
96E2F1_21310950_ChIP-Seq_MCF-7_Human1.25266537
97TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.24437204
98TCF4_22108803_ChIP-Seq_LS180_Human1.24082228
99RUNX1_27457419_Chip-Seq_LIVER_Mouse1.22071395
100SOX9_26525672_Chip-Seq_HEART_Mouse1.22020597
101RUNX2_22187159_ChIP-Seq_PCA_Human1.21998421
102TP53_16413492_ChIP-PET_HCT116_Human1.21655556
103TP53_18474530_ChIP-ChIP_U2OS_Human1.20659588
104ZFX_18555785_Chip-Seq_ESCs_Mouse1.20592765
105MYC_18940864_ChIP-ChIP_HL60_Human1.20365027
106ARNT_22903824_ChIP-Seq_MCF-7_Human1.20353742
107RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.20085091
108UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18559142
109WT1_19549856_ChIP-ChIP_CCG9911_Human1.17769041
110SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.17320117
111PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16286449
112GABP_17652178_ChIP-ChIP_JURKAT_Human1.16013715
113HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.15205586
114CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14675215
115KLF4_18555785_Chip-Seq_ESCs_Mouse1.14666074
116BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.14448447
117JARID2_20075857_ChIP-Seq_MESCs_Mouse1.13760272
118FLI1_21867929_ChIP-Seq_TH2_Mouse1.12989222
119AHR_22903824_ChIP-Seq_MCF-7_Human1.12067589
120SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.11819145
121LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11613286
122PU1_27457419_Chip-Seq_LIVER_Mouse1.11524769
123EZH2_18974828_ChIP-Seq_MESCs_Mouse1.10700638
124RNF2_18974828_ChIP-Seq_MESCs_Mouse1.10700638
125RNF2_27304074_Chip-Seq_ESCs_Mouse1.10204469
126CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.09744568
127STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.08462059
128KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.07901344
129FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.07605068
130KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07326721
131TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06483005
132YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04622698
133FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.02907242
134PRDM14_20953172_ChIP-Seq_ESCs_Human1.02901567
135TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01940283

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting3.84467739
2MP0006292_abnormal_olfactory_placode3.56718752
3MP0000566_synostosis3.43687192
4MP0001188_hyperpigmentation3.14849386
5MP0008057_abnormal_DNA_replication3.11218490
6MP0005409_darkened_coat_color3.09804385
7MP0005171_absent_coat_pigmentation2.90478400
8MP0003121_genomic_imprinting2.65343204
9MP0003136_yellow_coat_color2.57598907
10MP0002938_white_spotting2.39352541
11MP0009697_abnormal_copulation2.38287026
12MP0000015_abnormal_ear_pigmentation2.35559307
13MP0003122_maternal_imprinting2.33092424
14MP0000569_abnormal_digit_pigmentation2.19773602
15MP0008877_abnormal_DNA_methylation2.11385285
16MP0005646_abnormal_pituitary_gland1.88197607
17MP0008058_abnormal_DNA_repair1.74816430
18MP0000427_abnormal_hair_cycle1.71585295
19MP0002163_abnormal_gland_morphology1.64869100
20MP0003880_abnormal_central_pattern1.64514978
21MP0000778_abnormal_nervous_system1.61383978
22MP0008789_abnormal_olfactory_epithelium1.60429692
23MP0009250_abnormal_appendicular_skeleto1.59115438
24MP0005379_endocrine/exocrine_gland_phen1.51697473
25MP0000049_abnormal_middle_ear1.51010769
26MP0003937_abnormal_limbs/digits/tail_de1.46972915
27MP0004885_abnormal_endolymph1.45564101
28MP0002396_abnormal_hematopoietic_system1.45321226
29MP0000631_abnormal_neuroendocrine_gland1.44246650
30MP0004142_abnormal_muscle_tone1.43934036
31MP0005394_taste/olfaction_phenotype1.41278377
32MP0005499_abnormal_olfactory_system1.41278377
33MP0003385_abnormal_body_wall1.40430146
34MP0005645_abnormal_hypothalamus_physiol1.39989461
35MP0004134_abnormal_chest_morphology1.37597498
36MP0002177_abnormal_outer_ear1.36867117
37MP0003077_abnormal_cell_cycle1.36694420
38MP0004043_abnormal_pH_regulation1.34918792
39MP0008995_early_reproductive_senescence1.34206928
40MP0003195_calcinosis1.32478052
41MP0000372_irregular_coat_pigmentation1.29998331
42MP0002638_abnormal_pupillary_reflex1.29839411
43MP0003941_abnormal_skin_development1.29448606
44MP0002102_abnormal_ear_morphology1.29260806
45MP0002928_abnormal_bile_duct1.26730822
46MP0010307_abnormal_tumor_latency1.25961651
47MP0008961_abnormal_basal_metabolism1.23575061
48MP0002234_abnormal_pharynx_morphology1.22830224
49MP0003890_abnormal_embryonic-extraembry1.22091264
50MP0003755_abnormal_palate_morphology1.21046821
51MP0002751_abnormal_autonomic_nervous1.19542282
52MP0005174_abnormal_tail_pigmentation1.19337852
53MP0005257_abnormal_intraocular_pressure1.17869083
54MP0003111_abnormal_nucleus_morphology1.17427898
55MP0001177_atelectasis1.16413236
56MP0001986_abnormal_taste_sensitivity1.15955037
57MP0010678_abnormal_skin_adnexa1.13336040
58MP0000678_abnormal_parathyroid_gland1.13160488
59MP0002009_preneoplasia1.12713249
60MP0010386_abnormal_urinary_bladder1.12063292
61MP0003123_paternal_imprinting1.11341061
62MP0003938_abnormal_ear_development1.10794779
63MP0002095_abnormal_skin_pigmentation1.10044351
64MP0001486_abnormal_startle_reflex1.09592287
65MP0002233_abnormal_nose_morphology1.08854810
66MP0005408_hypopigmentation1.08166474
67MP0009046_muscle_twitch1.06160201
68MP0002210_abnormal_sex_determination1.03586421
69MP0003283_abnormal_digestive_organ1.03566189
70MP0001929_abnormal_gametogenesis1.01103520
71MP0003567_abnormal_fetal_cardiomyocyte1.00697692
72MP0003786_premature_aging1.00482290
73MP0002116_abnormal_craniofacial_bone0.99996024
74MP0010030_abnormal_orbit_morphology0.99494138
75MP0005391_vision/eye_phenotype0.98761683
76MP0001186_pigmentation_phenotype0.97306208
77MP0004215_abnormal_myocardial_fiber0.97019277
78MP0000026_abnormal_inner_ear0.95794828
79MP0002109_abnormal_limb_morphology0.94877185
80MP0005367_renal/urinary_system_phenotyp0.94840823
81MP0000516_abnormal_urinary_system0.94840823
82MP0004742_abnormal_vestibular_system0.94626986
83MP0005075_abnormal_melanosome_morpholog0.94038814
84MP0005503_abnormal_tendon_morphology0.93678073
85MP0002249_abnormal_larynx_morphology0.93349583
86MP0001286_abnormal_eye_development0.92268143
87MP0006072_abnormal_retinal_apoptosis0.92076198
88MP0001485_abnormal_pinna_reflex0.91363341
89MP0001346_abnormal_lacrimal_gland0.90884829
90MP0004957_abnormal_blastocyst_morpholog0.90680029
91MP0002557_abnormal_social/conspecific_i0.89921563
92MP0001963_abnormal_hearing_physiology0.88960096
93MP0000653_abnormal_sex_gland0.88559050
94MP0003698_abnormal_male_reproductive0.88548277
95MP0003935_abnormal_craniofacial_develop0.88303842
96MP0005195_abnormal_posterior_eye0.87561989
97MP0003942_abnormal_urinary_system0.87019311
98MP0001324_abnormal_eye_pigmentation0.87016075
99MP0004381_abnormal_hair_follicle0.85688097
100MP0000613_abnormal_salivary_gland0.85505842
101MP0001293_anophthalmia0.84745189
102MP0005220_abnormal_exocrine_pancreas0.83938247
103MP0000432_abnormal_head_morphology0.83899410
104MP0010094_abnormal_chromosome_stability0.83777950
105MP0002160_abnormal_reproductive_system0.83619547
106MP0001905_abnormal_dopamine_level0.82839306
107MP0002697_abnormal_eye_size0.82828443
108MP0001145_abnormal_male_reproductive0.82787321
109MP0002084_abnormal_developmental_patter0.82203126
110MP0002277_abnormal_respiratory_mucosa0.81210853
111MP0006276_abnormal_autonomic_nervous0.81123063
112MP0004197_abnormal_fetal_growth/weight/0.80806611
113MP0002876_abnormal_thyroid_physiology0.80781852
114MP0001299_abnormal_eye_distance/0.79926995
115MP0002114_abnormal_axial_skeleton0.79893890
116MP0005386_behavior/neurological_phenoty0.78689239
117MP0004924_abnormal_behavior0.78689239
118MP0000955_abnormal_spinal_cord0.78584813
119MP0003943_abnormal_hepatobiliary_system0.77722416
120MP0000681_abnormal_thyroid_gland0.77211056
121MP0005389_reproductive_system_phenotype0.76914849
122MP0002752_abnormal_somatic_nervous0.76225745
123MP0005253_abnormal_eye_physiology0.76071436
124MP0009703_decreased_birth_body0.76045099
125MP0000762_abnormal_tongue_morphology0.75377526
126MP0003718_maternal_effect0.74991581
127MP0002272_abnormal_nervous_system0.74879724
128MP0005084_abnormal_gallbladder_morpholo0.74244561
129MP0002075_abnormal_coat/hair_pigmentati0.73940342
130MP0001879_abnormal_lymphatic_vessel0.73915314
131MP0008007_abnormal_cellular_replicative0.73224639
132MP0005187_abnormal_penis_morphology0.71607277
133MP0000428_abnormal_craniofacial_morphol0.71330975
134MP0001502_abnormal_circadian_rhythm0.71126754
135MP0008775_abnormal_heart_ventricle0.70945033
136MP0008932_abnormal_embryonic_tissue0.70828292
137MP0005551_abnormal_eye_electrophysiolog0.70790173
138MP0000383_abnormal_hair_follicle0.70499267
139MP0001501_abnormal_sleep_pattern0.70144197
140MP0000647_abnormal_sebaceous_gland0.68366957
141MP0009745_abnormal_behavioral_response0.66562079
142MP0001984_abnormal_olfaction0.66069752
143MP0002184_abnormal_innervation0.65664769
144MP0003861_abnormal_nervous_system0.65557414

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)3.82529765
2Chromsome breakage (HP:0040012)3.71530012
3Abnormality of the labia minora (HP:0012880)3.59773490
4True hermaphroditism (HP:0010459)3.21831518
5Chronic hepatic failure (HP:0100626)3.01803749
6Pancreatic fibrosis (HP:0100732)2.90463696
7Abnormality of incisor morphology (HP:0011063)2.85276320
8Volvulus (HP:0002580)2.74075948
9Aplasia/Hypoplasia of the uvula (HP:0010293)2.68477212
10Hyperventilation (HP:0002883)2.62391889
11Nephroblastoma (Wilms tumor) (HP:0002667)2.60508178
12Nephronophthisis (HP:0000090)2.56273758
13Lip pit (HP:0100267)2.54550720
14Molar tooth sign on MRI (HP:0002419)2.54294965
15Abnormality of midbrain morphology (HP:0002418)2.54294965
16Abnormality of the renal cortex (HP:0011035)2.53854655
17White forelock (HP:0002211)2.49462300
18Embryonal renal neoplasm (HP:0011794)2.48221477
19Cupped ear (HP:0000378)2.46200834
20Abnormality of the nasal septum (HP:0000419)2.45787401
21Abnormality of the renal medulla (HP:0100957)2.45701495
22Sloping forehead (HP:0000340)2.44192218
23Abnormal hair whorl (HP:0010721)2.43462735
24Pancreatic cysts (HP:0001737)2.42488314
25Protruding tongue (HP:0010808)2.42009155
26Tubulointerstitial nephritis (HP:0001970)2.36701283
27Osteomalacia (HP:0002749)2.33470256
28Patchy hypopigmentation of hair (HP:0011365)2.30790966
29Abnormality of the renal collecting system (HP:0004742)2.29012917
30Aplasia/Hypoplasia of the fovea (HP:0008060)2.28471351
31Hypoplasia of the fovea (HP:0007750)2.28471351
32Oligodactyly (hands) (HP:0001180)2.28184728
33Intestinal atresia (HP:0011100)2.27887536
34Gaze-evoked nystagmus (HP:0000640)2.27390621
35Adrenal hypoplasia (HP:0000835)2.27163519
36Preaxial hand polydactyly (HP:0001177)2.26538788
37Tubular atrophy (HP:0000092)2.26180593
38Decreased circulating renin level (HP:0003351)2.26163656
39Stomach cancer (HP:0012126)2.25644410
40Abnormality of the incisor (HP:0000676)2.22920079
41Postaxial foot polydactyly (HP:0001830)2.20962873
42Absent eyebrow (HP:0002223)2.19951254
43Median cleft lip (HP:0000161)2.18679904
44Ectopic kidney (HP:0000086)2.16342486
45Midline defect of the nose (HP:0004122)2.13559821
46Clubbing of toes (HP:0100760)2.12780449
47Medial flaring of the eyebrow (HP:0010747)2.10641728
48Poor coordination (HP:0002370)2.05924811
49Colon cancer (HP:0003003)2.04828696
50Occipital encephalocele (HP:0002085)2.04136962
51Congenital sensorineural hearing impairment (HP:0008527)2.02985878
52Broad-based gait (HP:0002136)2.00608541
53Submucous cleft hard palate (HP:0000176)2.00252738
54Progressive cerebellar ataxia (HP:0002073)2.00082807
55Abnormality of the parietal bone (HP:0002696)1.99739534
56Abnormality of the nasolacrimal system (HP:0000614)1.99606531
57Genetic anticipation (HP:0003743)1.99328168
58Duplicated collecting system (HP:0000081)1.99263991
59Hypothermia (HP:0002045)1.99200365
60Hypoplastic labia majora (HP:0000059)1.97144798
61Abnormality of the fingertips (HP:0001211)1.96729648
62Febrile seizures (HP:0002373)1.94978756
63Abnormality of the columella (HP:0009929)1.94709005
64Nephrogenic diabetes insipidus (HP:0009806)1.92056915
65Hypoplastic iliac wings (HP:0002866)1.91869384
66Bell-shaped thorax (HP:0001591)1.91197434
67Abnormality of the lacrimal duct (HP:0011481)1.91077323
68Optic nerve coloboma (HP:0000588)1.90864547
69Hip dysplasia (HP:0001385)1.90446652
70Neoplasm of the tracheobronchial system (HP:0100552)1.90431853
71Abnormal drinking behavior (HP:0030082)1.88880638
72Polydipsia (HP:0001959)1.88880638
73Decreased lacrimation (HP:0000633)1.88563342
74Rhabdomyosarcoma (HP:0002859)1.86668868
75Narrow forehead (HP:0000341)1.86614617
76Fibular hypoplasia (HP:0003038)1.85773932
77Abnormality of DNA repair (HP:0003254)1.85704626
78Astigmatism (HP:0000483)1.85645491
79Patellar aplasia (HP:0006443)1.85584629
80Acute lymphatic leukemia (HP:0006721)1.85198479
81Abnormality of the preputium (HP:0100587)1.85119418
82Aplasia/Hypoplasia of the tongue (HP:0010295)1.84608010
83Nasolacrimal duct obstruction (HP:0000579)1.84230463
84Highly arched eyebrow (HP:0002553)1.84173783
85Cystic liver disease (HP:0006706)1.83021873
86Thyroiditis (HP:0100646)1.82700561
87Deep philtrum (HP:0002002)1.82692930
88Gastrointestinal atresia (HP:0002589)1.82185340
89Fair hair (HP:0002286)1.82051148
90Truncal obesity (HP:0001956)1.81883104
91Small intestinal stenosis (HP:0012848)1.81564387
92Duodenal stenosis (HP:0100867)1.81564387
93Male pseudohermaphroditism (HP:0000037)1.80713792
94Sclerocornea (HP:0000647)1.80274857
95Hepatoblastoma (HP:0002884)1.79647960
96Neoplasm of the oral cavity (HP:0100649)1.79469268
97Congenital hepatic fibrosis (HP:0002612)1.79115152
98Birth length less than 3rd percentile (HP:0003561)1.79112510
99Postaxial hand polydactyly (HP:0001162)1.78987760
100Cutaneous finger syndactyly (HP:0010554)1.78066441
101Hypoplastic ischia (HP:0003175)1.77729200
102Widely spaced teeth (HP:0000687)1.77657373
103Aplasia/Hypoplasia of the tibia (HP:0005772)1.77211918
104Acute myeloid leukemia (HP:0004808)1.77176776
105Abnormal ciliary motility (HP:0012262)1.76201508
106Abnormality of the duodenum (HP:0002246)1.75328230
107Alveolar cell carcinoma (HP:0006519)1.74858593
108Abnormality of the labia majora (HP:0012881)1.74659198
109Papillary thyroid carcinoma (HP:0002895)1.73840895
110Septo-optic dysplasia (HP:0100842)1.73624883
111Abnormality of the ischium (HP:0003174)1.73169559
112Bifid tongue (HP:0010297)1.72948439
113Optic nerve hypoplasia (HP:0000609)1.72174240
114Cerebellar dysplasia (HP:0007033)1.71929964
115Abnormality of the carotid arteries (HP:0005344)1.71563954
116Glioma (HP:0009733)1.71313369
117Absent rod-and cone-mediated responses on ERG (HP:0007688)1.71057551
118Embryonal neoplasm (HP:0002898)1.70526209
119Abnormal rod and cone electroretinograms (HP:0008323)1.70315169
120Congenital primary aphakia (HP:0007707)1.70035505
121Abnormality of the fovea (HP:0000493)1.69405961
122Dandy-Walker malformation (HP:0001305)1.67987669
123Gait imbalance (HP:0002141)1.67572433
124Prominent nasal bridge (HP:0000426)1.67035772
125Reticulocytopenia (HP:0001896)1.66151438
126Abnormal respiratory motile cilium physiology (HP:0012261)1.65724949
127Aplasia/Hypoplasia of the patella (HP:0006498)1.65645338
128Aplasia/Hypoplasia of the sternum (HP:0006714)1.65463484
129Meckel diverticulum (HP:0002245)1.64729867
130Congenital stationary night blindness (HP:0007642)1.64669844
131Labial hypoplasia (HP:0000066)1.63753352
132Aqueductal stenosis (HP:0002410)1.62949862
133Renal hypoplasia (HP:0000089)1.62564620
134Cutaneous syndactyly (HP:0012725)1.62371984
135Abnormal respiratory epithelium morphology (HP:0012253)1.62227905
136Genital tract atresia (HP:0001827)1.62183514
137Anencephaly (HP:0002323)1.61968949
138Absent/shortened dynein arms (HP:0200106)1.61786800
139Dynein arm defect of respiratory motile cilia (HP:0012255)1.61786800
140Gastroesophageal reflux (HP:0002020)1.60817712
141Chorioretinal coloboma (HP:0000567)1.59892491
142Morphological abnormality of the middle ear (HP:0008609)1.59533649
143Vaginal atresia (HP:0000148)1.59443252
144Abnormality of chromosome stability (HP:0003220)1.59069374
145Abnormality of the ileum (HP:0001549)1.58720653
146Abnormality of the metopic suture (HP:0005556)1.58412286
147Generalized hypopigmentation of hair (HP:0011358)1.58210133
148Asymmetry of the thorax (HP:0001555)1.58178735
149Aganglionic megacolon (HP:0002251)1.56304714
150Hyperaldosteronism (HP:0000859)1.56302801
151Facial cleft (HP:0002006)1.55983571
152Enlarged kidneys (HP:0000105)1.55729996

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK3.27020429
2CASK3.26933087
3MKNK23.14522465
4INSRR2.95614160
5AKT32.79716362
6ZAK2.76748062
7SRPK12.65555864
8MKNK12.57848294
9ERBB32.38421758
10WNK42.26603769
11BRSK22.18400879
12BRD42.08844597
13BMPR1B2.03635353
14PRPF4B1.99832163
15WEE11.94531240
16NUAK11.86380565
17BMPR21.83168786
18NEK61.82739320
19MAPK131.78544701
20PLK41.77580106
21SGK21.59803396
22MAPK151.50703566
23MUSK1.43382979
24FRK1.40357042
25MAP2K71.40123452
26YES11.36268535
27CDK81.34168550
28CDK31.29811204
29IRAK31.29671563
30IRAK41.27343237
31PDK21.22871964
32PLK21.22529403
33VRK11.20660924
34EPHA41.14947466
35CLK11.11380082
36EIF2AK21.10720725
37PINK11.09657561
38TAF11.09320209
39SGK2231.09242703
40SGK4941.09242703
41PIK3CA1.08796068
42PLK31.08777808
43PAK31.07353146
44SIK31.06987236
45FGFR21.04683664
46TRIM281.02594596
47MAP3K140.99058867
48PNCK0.97091710
49PASK0.93679951
50BCR0.93522182
51ACVR1B0.91505811
52TGFBR10.90299604
53IRAK10.90240240
54ATR0.89694735
55STK160.89274945
56CDC70.87619173
57TXK0.86603203
58EIF2AK10.84740562
59SGK30.84561733
60NTRK30.83389431
61PKN10.82340505
62WNK10.80816243
63EIF2AK30.79672444
64DMPK0.78528343
65PLK10.77165665
66STK38L0.75554335
67ADRBK20.75401969
68STK390.73030600
69CAMK1D0.72730967
70TNK20.71895946
71IRAK20.71037629
72TTK0.70957850
73CDK120.70105801
74ATM0.68901244
75TRPM70.68367503
76OXSR10.67360387
77PIK3CG0.66768105
78TSSK60.66597331
79CSNK1E0.65876309
80LATS10.65752396
81CSNK1A1L0.65489456
82SGK10.65296813
83GRK10.63807641
84BUB10.62612022
85FGFR10.62328300
86CHEK20.62208407
87GRK70.61757362
88BRSK10.61133945
89PRKCE0.60782881
90WNK30.57314302
91MARK30.55039717
92BCKDK0.54861167
93NEK10.54692091
94NEK20.54605563
95MELK0.53650106
96NEK90.53132022
97MAP3K40.52256575
98STK30.50626338
99CCNB10.50486067
100PRKG10.48210070
101PRKCG0.48182761
102DYRK1A0.47736829
103MAP3K60.47644529
104NTRK20.46934541
105MARK10.45395370
106OBSCN0.45317266
107MAPK140.44620869
108MAPKAPK50.43894319
109CDK20.43787560
110CHUK0.43501639
111CDK10.43388683
112HIPK20.43353836
113CSNK1D0.43210957
114RPS6KB10.42930637
115CSNK1G10.42713335
116CDC42BPA0.42638459
117STK240.42473081
118MAP4K20.42084217
119NME10.41978890
120CHEK10.41942659
121CSNK1A10.41642827
122MAPK70.41537652
123GSK3B0.41062407
124AURKB0.40814315
125TAOK30.39044860
126CAMK1G0.38265980
127TIE10.38102455
128NLK0.37988516
129TEC0.37789702
130RPS6KA50.37667565
131CDK70.36853147
132PRKDC0.34741029
133ERBB40.34713736
134FGFR30.33398814

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034602.47789503
2Propanoate metabolism_Homo sapiens_hsa006402.43655916
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.40575318
4Basal transcription factors_Homo sapiens_hsa030222.32483154
5Non-homologous end-joining_Homo sapiens_hsa034502.22680104
6Protein export_Homo sapiens_hsa030602.13474899
7Homologous recombination_Homo sapiens_hsa034402.06198909
8Dorso-ventral axis formation_Homo sapiens_hsa043201.90399170
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.81073517
10Mismatch repair_Homo sapiens_hsa034301.77854000
11Butanoate metabolism_Homo sapiens_hsa006501.71813230
12Taste transduction_Homo sapiens_hsa047421.70902684
13Nicotine addiction_Homo sapiens_hsa050331.70182222
14RNA degradation_Homo sapiens_hsa030181.66316523
15Nucleotide excision repair_Homo sapiens_hsa034201.55000603
16Phototransduction_Homo sapiens_hsa047441.53465719
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.50349369
18mRNA surveillance pathway_Homo sapiens_hsa030151.49540341
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.48041487
20Serotonergic synapse_Homo sapiens_hsa047261.46624802
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.46268099
22Nitrogen metabolism_Homo sapiens_hsa009101.38825644
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36325811
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.35814218
25Spliceosome_Homo sapiens_hsa030401.34379124
26RNA polymerase_Homo sapiens_hsa030201.31368967
27Axon guidance_Homo sapiens_hsa043601.25102967
28Basal cell carcinoma_Homo sapiens_hsa052171.23848684
29One carbon pool by folate_Homo sapiens_hsa006701.22649705
30Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.22297970
31Linoleic acid metabolism_Homo sapiens_hsa005911.21856462
32Cell cycle_Homo sapiens_hsa041101.19554113
33Wnt signaling pathway_Homo sapiens_hsa043101.18621519
34Circadian rhythm_Homo sapiens_hsa047101.18234635
35SNARE interactions in vesicular transport_Homo sapiens_hsa041301.16978392
36Morphine addiction_Homo sapiens_hsa050321.12629151
37Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.11625455
38Prostate cancer_Homo sapiens_hsa052151.10797211
39Selenocompound metabolism_Homo sapiens_hsa004501.08741834
40Glutamatergic synapse_Homo sapiens_hsa047241.07382713
41Transcriptional misregulation in cancer_Homo sapiens_hsa052021.06783436
42Sphingolipid metabolism_Homo sapiens_hsa006001.06220687
43Circadian entrainment_Homo sapiens_hsa047131.05255868
44Long-term depression_Homo sapiens_hsa047301.01888500
45Insulin secretion_Homo sapiens_hsa049111.01248910
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.99861980
47Hedgehog signaling pathway_Homo sapiens_hsa043400.98871184
48Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.98827294
49Base excision repair_Homo sapiens_hsa034100.98180238
50DNA replication_Homo sapiens_hsa030300.97145788
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.96601875
52Amphetamine addiction_Homo sapiens_hsa050310.94558221
53Ovarian steroidogenesis_Homo sapiens_hsa049130.94522303
54p53 signaling pathway_Homo sapiens_hsa041150.93208018
55Autoimmune thyroid disease_Homo sapiens_hsa053200.90797593
56Melanoma_Homo sapiens_hsa052180.89133648
57ABC transporters_Homo sapiens_hsa020100.88233336
58Ether lipid metabolism_Homo sapiens_hsa005650.87334107
59Oocyte meiosis_Homo sapiens_hsa041140.86917685
60Olfactory transduction_Homo sapiens_hsa047400.83210485
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82142966
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.80579645
63Cocaine addiction_Homo sapiens_hsa050300.79231422
64Arachidonic acid metabolism_Homo sapiens_hsa005900.78142038
65Regulation of autophagy_Homo sapiens_hsa041400.77551301
66Calcium signaling pathway_Homo sapiens_hsa040200.76759368
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76724210
68TGF-beta signaling pathway_Homo sapiens_hsa043500.74926764
69Purine metabolism_Homo sapiens_hsa002300.73394663
70GABAergic synapse_Homo sapiens_hsa047270.72714151
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72411577
72Cholinergic synapse_Homo sapiens_hsa047250.71829153
73Caffeine metabolism_Homo sapiens_hsa002320.70292385
74MicroRNAs in cancer_Homo sapiens_hsa052060.70253987
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68377969
76Tryptophan metabolism_Homo sapiens_hsa003800.68337734
77Dopaminergic synapse_Homo sapiens_hsa047280.68334837
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.67300382
79cAMP signaling pathway_Homo sapiens_hsa040240.66584503
80Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65852556
81Colorectal cancer_Homo sapiens_hsa052100.65318810
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65225128
83Long-term potentiation_Homo sapiens_hsa047200.64482089
84Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.63966585
85Melanogenesis_Homo sapiens_hsa049160.62901538
86Renin secretion_Homo sapiens_hsa049240.60705653
87ErbB signaling pathway_Homo sapiens_hsa040120.60626500
88Ras signaling pathway_Homo sapiens_hsa040140.60339432
89RNA transport_Homo sapiens_hsa030130.60305086
90Retinol metabolism_Homo sapiens_hsa008300.59667932
91Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58353376
92Pyrimidine metabolism_Homo sapiens_hsa002400.57973219
93NF-kappa B signaling pathway_Homo sapiens_hsa040640.56930376
94Adherens junction_Homo sapiens_hsa045200.56872717
95Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56780425
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.56503525
97Huntingtons disease_Homo sapiens_hsa050160.56173864
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55945712
99Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.55680853
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55333191
101Herpes simplex infection_Homo sapiens_hsa051680.54841423
102Chemical carcinogenesis_Homo sapiens_hsa052040.54749602
103Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54031308
104MAPK signaling pathway_Homo sapiens_hsa040100.52727833
105Type II diabetes mellitus_Homo sapiens_hsa049300.52614137
106Pathways in cancer_Homo sapiens_hsa052000.52422731
107Peroxisome_Homo sapiens_hsa041460.51851298
108Hippo signaling pathway_Homo sapiens_hsa043900.51705919
109Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50956554
110Cysteine and methionine metabolism_Homo sapiens_hsa002700.49984281
111Vascular smooth muscle contraction_Homo sapiens_hsa042700.48717079
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48322977
113Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.48291341
114PI3K-Akt signaling pathway_Homo sapiens_hsa041510.47704526
115Dilated cardiomyopathy_Homo sapiens_hsa054140.46411267
116Notch signaling pathway_Homo sapiens_hsa043300.45640985
117Vitamin digestion and absorption_Homo sapiens_hsa049770.45111060
118Aldosterone synthesis and secretion_Homo sapiens_hsa049250.45110643
119FoxO signaling pathway_Homo sapiens_hsa040680.45045299
120Endometrial cancer_Homo sapiens_hsa052130.44903211
121Choline metabolism in cancer_Homo sapiens_hsa052310.44047410
122Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43705561
123NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43234241
124ECM-receptor interaction_Homo sapiens_hsa045120.42428589
125Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.42340576
126HTLV-I infection_Homo sapiens_hsa051660.41629609
127Glycerolipid metabolism_Homo sapiens_hsa005610.41614904
128Rheumatoid arthritis_Homo sapiens_hsa053230.39905901
129Hematopoietic cell lineage_Homo sapiens_hsa046400.39358703
130Lysine degradation_Homo sapiens_hsa003100.39173130
131beta-Alanine metabolism_Homo sapiens_hsa004100.38581288
132Steroid biosynthesis_Homo sapiens_hsa001000.38422941
133Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38356959
134Salivary secretion_Homo sapiens_hsa049700.38172383
135Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38134322
136Inositol phosphate metabolism_Homo sapiens_hsa005620.38123426
137Intestinal immune network for IgA production_Homo sapiens_hsa046720.38099368
138Cardiac muscle contraction_Homo sapiens_hsa042600.30978065

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