SREBF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1alpha-linolenic acid metabolic process (GO:0036109)6.30403761
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.22592646
3L-phenylalanine catabolic process (GO:0006559)6.22592646
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.99084647
5L-phenylalanine metabolic process (GO:0006558)5.99084647
6desmosome organization (GO:0002934)5.98791638
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.80324331
8aromatic amino acid family catabolic process (GO:0009074)5.27657403
9sulfur amino acid catabolic process (GO:0000098)5.20710007
10high-density lipoprotein particle remodeling (GO:0034375)4.78643500
11urea cycle (GO:0000050)4.75292222
12urea metabolic process (GO:0019627)4.75292222
13kynurenine metabolic process (GO:0070189)4.69841563
14peptidyl-glutamic acid carboxylation (GO:0017187)4.69240475
15protein carboxylation (GO:0018214)4.69240475
16complement activation, alternative pathway (GO:0006957)4.67514331
17bile acid biosynthetic process (GO:0006699)4.66620607
18cysteine metabolic process (GO:0006534)4.65646806
19regulation of triglyceride catabolic process (GO:0010896)4.62178547
20negative regulation of fibrinolysis (GO:0051918)4.59901463
21glyoxylate metabolic process (GO:0046487)4.55553936
22indole-containing compound catabolic process (GO:0042436)4.51792762
23indolalkylamine catabolic process (GO:0046218)4.51792762
24tryptophan catabolic process (GO:0006569)4.51792762
25reverse cholesterol transport (GO:0043691)4.48745774
26fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.46140638
27plasma lipoprotein particle clearance (GO:0034381)4.45132666
28regulation of protein activation cascade (GO:2000257)4.40388076
29regulation of cholesterol homeostasis (GO:2000188)4.38101186
30nitrogen cycle metabolic process (GO:0071941)4.34458918
31activation of Rac GTPase activity (GO:0032863)4.33021964
32negative regulation of sterol transport (GO:0032372)4.32852419
33negative regulation of cholesterol transport (GO:0032375)4.32852419
34semaphorin-plexin signaling pathway (GO:0071526)4.32327388
35regulation of fibrinolysis (GO:0051917)4.29060027
36tryptophan metabolic process (GO:0006568)4.26493010
37lysine metabolic process (GO:0006553)4.26425154
38lysine catabolic process (GO:0006554)4.26425154
39hemidesmosome assembly (GO:0031581)4.24831118
40serine family amino acid catabolic process (GO:0009071)4.24609409
41positive regulation of fatty acid beta-oxidation (GO:0032000)4.24493982
42negative regulation of cell size (GO:0045792)4.17301563
43protein-lipid complex remodeling (GO:0034368)4.17202498
44macromolecular complex remodeling (GO:0034367)4.17202498
45plasma lipoprotein particle remodeling (GO:0034369)4.17202498
46regulation of cholesterol esterification (GO:0010872)4.17121854
47regulation of complement activation (GO:0030449)4.15976886
48acylglycerol homeostasis (GO:0055090)4.13953584
49triglyceride homeostasis (GO:0070328)4.13953584
50phospholipid efflux (GO:0033700)4.13563288
51homocysteine metabolic process (GO:0050667)4.12042079
52amino-acid betaine metabolic process (GO:0006577)4.10482141
53bile acid metabolic process (GO:0008206)4.09844068
54regulation of glucose import in response to insulin stimulus (GO:2001273)4.08075069
55proline biosynthetic process (GO:0006561)4.03575018
56ethanol oxidation (GO:0006069)4.03447656
57acetyl-CoA metabolic process (GO:0006084)4.00070983
58valine metabolic process (GO:0006573)3.99155658
59positive regulation of lipid catabolic process (GO:0050996)3.93422202
60COPI coating of Golgi vesicle (GO:0048205)3.93081504
61Golgi transport vesicle coating (GO:0048200)3.93081504
62alpha-amino acid catabolic process (GO:1901606)3.89348458
63low-density lipoprotein particle clearance (GO:0034383)3.89265339
64apoptotic process involved in morphogenesis (GO:0060561)3.89105608
65atrioventricular valve morphogenesis (GO:0003181)3.87845467
66tyrosine metabolic process (GO:0006570)3.87146407
67regulation of fatty acid beta-oxidation (GO:0031998)3.86373582
68epithelial cell-cell adhesion (GO:0090136)3.83034184
69cellular modified amino acid catabolic process (GO:0042219)3.80418233
70plasma lipoprotein particle assembly (GO:0034377)3.78323946
71aromatic amino acid family metabolic process (GO:0009072)3.77142563
72cytoskeletal anchoring at plasma membrane (GO:0007016)3.75962503
73biotin metabolic process (GO:0006768)3.73980802
74glycine metabolic process (GO:0006544)3.73110307
75phospholipid homeostasis (GO:0055091)3.72166503
76cellular amino acid catabolic process (GO:0009063)3.68345181
77mannose metabolic process (GO:0006013)3.66505537
78cholesterol efflux (GO:0033344)3.63110504
79linoleic acid metabolic process (GO:0043651)3.62408527
80fatty acid beta-oxidation (GO:0006635)3.59585262
81fatty-acyl-CoA biosynthetic process (GO:0046949)3.54987133
82short-chain fatty acid metabolic process (GO:0046459)3.54588442
83cellular ketone body metabolic process (GO:0046950)3.54172171
84positive regulation of fatty acid oxidation (GO:0046321)3.51457046
85fatty acid oxidation (GO:0019395)3.51441165
86serine family amino acid metabolic process (GO:0009069)3.51314911
872-oxoglutarate metabolic process (GO:0006103)3.51143646
88planar cell polarity pathway involved in neural tube closure (GO:0090179)3.51097277
89glutamate metabolic process (GO:0006536)3.50315114
90positive regulation of triglyceride lipase activity (GO:0061365)3.49872442
91positive regulation of lipoprotein lipase activity (GO:0051006)3.49872442
92long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.49711618
93protein-lipid complex assembly (GO:0065005)3.49244125
94coenzyme catabolic process (GO:0009109)3.47799421
95* positive regulation of triglyceride metabolic process (GO:0090208)3.46528157
96low-density lipoprotein particle remodeling (GO:0034374)3.46388362
97adherens junction assembly (GO:0034333)3.46307864
98serine family amino acid biosynthetic process (GO:0009070)3.46271252
99lipid oxidation (GO:0034440)3.46073451
100cholesterol homeostasis (GO:0042632)3.45623120
101bile acid and bile salt transport (GO:0015721)3.43444001
102negative regulation of fatty acid transport (GO:2000192)3.43429056
103glucose catabolic process (GO:0006007)3.42947831
104branching involved in mammary gland duct morphogenesis (GO:0060444)3.41622416
105dicarboxylic acid biosynthetic process (GO:0043650)3.41588368
106negative regulation of lipase activity (GO:0060192)3.41453234
107cell-substrate junction assembly (GO:0007044)3.41040437
108sterol homeostasis (GO:0055092)3.40584571
109focal adhesion assembly (GO:0048041)3.39984422
110cell-substrate adherens junction assembly (GO:0007045)3.39984422
111* regulation of cholesterol biosynthetic process (GO:0045540)3.39042263
112fatty acid transmembrane transport (GO:1902001)3.38576704
113basement membrane organization (GO:0071711)3.37801739
114plasma lipoprotein particle organization (GO:0071827)3.37729172
115acyl-CoA biosynthetic process (GO:0071616)3.36907402
116thioester biosynthetic process (GO:0035384)3.36907402
117intestinal cholesterol absorption (GO:0030299)3.36291171
118positive regulation of Cdc42 GTPase activity (GO:0043089)3.34793001
119fatty acid catabolic process (GO:0009062)3.34788973
120lipoprotein metabolic process (GO:0042157)3.33917921
121organic acid catabolic process (GO:0016054)3.33688868
122carboxylic acid catabolic process (GO:0046395)3.33688868
123protein retention in ER lumen (GO:0006621)3.33676401
124epithelial cell differentiation involved in prostate gland development (GO:0060742)3.33596459
125monocarboxylic acid catabolic process (GO:0072329)3.32943709
126very-low-density lipoprotein particle assembly (GO:0034379)3.32214281
127cellular glucuronidation (GO:0052695)3.31708547
128cell-cell junction maintenance (GO:0045217)3.31115572
129peptidyl-tyrosine autophosphorylation (GO:0038083)3.30723726
130* regulation of triglyceride metabolic process (GO:0090207)3.29798732
131proline metabolic process (GO:0006560)3.29230622
132endothelial cell chemotaxis (GO:0035767)3.28567480
133negative regulation of erythrocyte differentiation (GO:0045647)3.27751404
134maternal placenta development (GO:0001893)3.24715176
135maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.19380200
136regulation of early endosome to late endosome transport (GO:2000641)3.17572965
137retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.16731563
138glucose 6-phosphate metabolic process (GO:0051156)3.15496666
139regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.13512336
140negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.11087188
141insulin-like growth factor receptor signaling pathway (GO:0048009)3.10394821
142regulation of extracellular matrix disassembly (GO:0010715)3.04771485
143regulation of water loss via skin (GO:0033561)3.03020065
144pentose-phosphate shunt (GO:0006098)2.96895010
145regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.94932508
146long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.90351344
147L-serine transport (GO:0015825)2.87234991
148myelin maintenance (GO:0043217)2.81078095
149establishment of apical/basal cell polarity (GO:0035089)2.78859907
150NADH metabolic process (GO:0006734)2.77680787
151protein localization to endosome (GO:0036010)2.75905444
152negative regulation of viral release from host cell (GO:1902187)2.75105912
153ear development (GO:0043583)2.70724015
154regulation of cholesterol storage (GO:0010885)2.67083875
155regulation of endothelial cell chemotaxis (GO:2001026)2.64619487
156* regulation of cholesterol metabolic process (GO:0090181)2.63989609
157bundle of His cell to Purkinje myocyte communication (GO:0086069)2.62983436
158receptor catabolic process (GO:0032801)2.62281968
159fatty acid homeostasis (GO:0055089)2.62280116
160serine transport (GO:0032329)2.59540344
161apoptotic process involved in development (GO:1902742)2.59512803
162positive regulation of receptor recycling (GO:0001921)2.58836693
163NADPH regeneration (GO:0006740)2.57041874
164multicellular organismal water homeostasis (GO:0050891)2.55579384
165white fat cell differentiation (GO:0050872)2.54604131
166lung epithelium development (GO:0060428)2.53964442
167regulation of chromatin binding (GO:0035561)2.53847077
168embryonic process involved in female pregnancy (GO:0060136)2.53298230
169regulation of mammary gland epithelial cell proliferation (GO:0033599)2.53187043
170regulation of translational fidelity (GO:0006450)2.52978561
171negative regulation of fatty acid biosynthetic process (GO:0045717)2.52586644
172positive regulation of keratinocyte differentiation (GO:0045618)2.51537262
173regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.49263817
174activation of MAPKKK activity (GO:0000185)2.49232010
175branching involved in salivary gland morphogenesis (GO:0060445)2.48395385
176positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.46388923
177G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.45746547
178triglyceride biosynthetic process (GO:0019432)2.45351439
179amyloid precursor protein catabolic process (GO:0042987)2.43308072
180dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.42819912
181regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.41552103
182regulation of apoptotic cell clearance (GO:2000425)2.40619792
183vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.40247969
184vascular endothelial growth factor signaling pathway (GO:0038084)2.39672518
185establishment of skin barrier (GO:0061436)2.39490257
186activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.38055713
187glutamine family amino acid biosynthetic process (GO:0009084)2.37693526

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.42309057
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.80844607
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.35502526
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.03822932
5* LXR_22158963_ChIP-Seq_LIVER_Mouse5.41330114
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.56965458
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.18558170
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.53481736
9* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.40708637
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.92815620
11CLOCK_20551151_ChIP-Seq_293T_Human2.79571198
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.75357068
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.68082080
14CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.64185935
15STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.40074047
16EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.20744462
17ZNF263_19887448_ChIP-Seq_K562_Human2.06469292
18RARG_19884340_ChIP-ChIP_MEFs_Mouse1.91227472
19STAT6_21828071_ChIP-Seq_BEAS2B_Human1.88330967
20TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.79154820
21* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.65631042
22ZFP281_18757296_ChIP-ChIP_E14_Mouse1.63242692
23* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.61396444
24ESR2_21235772_ChIP-Seq_MCF-7_Human1.60386919
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.59076987
26SMC4_20622854_ChIP-Seq_HELA_Human1.58127373
27EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.57994597
28FOXA2_19822575_ChIP-Seq_HepG2_Human1.56029855
29TET1_21451524_ChIP-Seq_MESCs_Mouse1.53907753
30ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.52033611
31DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.51635652
32HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.50476689
33STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.48988662
34SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.45798341
35LXR_22292898_ChIP-Seq_THP-1_Human1.44784931
36CTCF_27219007_Chip-Seq_ERYTHROID_Human1.44047417
37SA1_27219007_Chip-Seq_ERYTHROID_Human1.42226806
38* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.41955753
39GATA1_22025678_ChIP-Seq_K562_Human1.41414694
40SOX2_27498859_Chip-Seq_STOMACH_Mouse1.40885503
41WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.35196130
42ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.34844352
43KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.34153551
44DNAJC2_21179169_ChIP-ChIP_NT2_Human1.34102937
45ESR1_15608294_ChIP-ChIP_MCF-7_Human1.31467615
46* KDM2B_26808549_Chip-Seq_JURKAT_Human1.29285033
47SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27173210
48* RACK7_27058665_Chip-Seq_MCF-7_Human1.22557759
49CTCF_27219007_Chip-Seq_Bcells_Human1.21204441
50CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.20856799
51SRY_22984422_ChIP-ChIP_TESTIS_Rat1.20445018
52* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18843935
53CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.16542678
54TP53_22127205_ChIP-Seq_IMR90_Human1.16152314
55ESR1_21235772_ChIP-Seq_MCF-7_Human1.16024909
56* HNF4A_19822575_ChIP-Seq_HepG2_Human1.15938924
57FOXO3_23340844_ChIP-Seq_DLD1_Human1.15791776
58PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.15479010
59* NCOR1_26117541_ChIP-Seq_K562_Human1.15272958
60TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.15005060
61ZFP281_27345836_Chip-Seq_ESCs_Mouse1.14464406
62* VDR_24763502_ChIP-Seq_THP-1_Human1.11565686
63* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10872692
64KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10620247
65TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10179431
66TRIM28_21343339_ChIP-Seq_HEK293_Human1.09499777
67* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09157256
68TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08234244
69TP63_22573176_ChIP-Seq_HFKS_Human1.08081995
70* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07916865
71ELF1_20517297_ChIP-Seq_JURKAT_Human1.07562187
72MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.06961894
73MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.05651222
74* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03211879
75UBF1/2_26484160_Chip-Seq_HMECs_Human1.02517117
76GATA4_25053715_ChIP-Seq_YYC3_Human1.02296851
77PPAR_26484153_Chip-Seq_NCI-H1993_Human1.00036063
78TET1_21490601_ChIP-Seq_MESCs_Mouse0.99742613
79SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.99058621
80ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.98089628
81* ELK3_25401928_ChIP-Seq_HUVEC_Human0.97965597
82SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.97250765
83MAF_26560356_Chip-Seq_TH2_Human0.96244983
84TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94031349
85BCL6_27268052_Chip-Seq_Bcells_Human0.92809956
86HIF1A_21447827_ChIP-Seq_MCF-7_Human0.91820521
87KLF5_25053715_ChIP-Seq_YYC3_Human0.91420655
88RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.91076110
89GATA1_22383799_ChIP-Seq_G1ME_Mouse0.90705355
90GATA1_19941826_ChIP-Seq_K562_Human0.90308979
91NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.89613488
92STAT3_1855785_ChIP-Seq_MESCs_Mouse0.88962365
93ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88335225
94* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.88160236
95GATA6_25053715_ChIP-Seq_YYC3_Human0.87700345
96* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.87606555
97KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.87056047
98* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.86699285
99KDM2B_26808549_Chip-Seq_SUP-B15_Human0.86263424
100KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.84479083
101AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.84241311
102* ATF3_27146783_Chip-Seq_COLON_Human0.83346544
103POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.82596311
104BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.82488572
105IRF8_22096565_ChIP-ChIP_GC-B_Human0.82281585
106KDM2B_26808549_Chip-Seq_DND41_Human0.81582670
107* TBX20_22328084_ChIP-Seq_HEART_Mouse0.80264158
108* TBX20_22080862_ChIP-Seq_HEART_Mouse0.80264158
109* CREB1_26743006_Chip-Seq_LNCaP_Human0.79451106
110* MYC_22102868_ChIP-Seq_BL_Human0.79188113
111RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.77274114
112SOX9_24532713_ChIP-Seq_HFSC_Mouse0.76162553
113SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.75985334
114VDR_21846776_ChIP-Seq_THP-1_Human0.75929829
115* TCF7_22412390_ChIP-Seq_EML_Mouse0.75804429
116* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.75723988
117* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.75411248
118IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.73864158
119* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.73376153
120* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.72788182
121GATA2_19941826_ChIP-Seq_K562_Human0.72464353
122* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.72408863
123ERG_21242973_ChIP-ChIP_JURKAT_Human0.72111572
124CDX2_20551321_ChIP-Seq_CACO-2_Human0.71950062
125NFIB_24661679_ChIP-Seq_LUNG_Mouse0.71285953
126PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.70503845
127* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.70453850
128FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.69586256
129RUNX1_27514584_Chip-Seq_MCF-7_Human0.69567942
130P68_20966046_ChIP-Seq_HELA_Human0.65272637
131GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.65235879
132FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.65220746
133TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.64922712
134BCOR_27268052_Chip-Seq_Bcells_Human0.64898549
135GATA3_24758297_ChIP-Seq_MCF-7_Human0.64818539
136* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.64664065
137GATA1_19941827_ChIP-Seq_MEL_Mouse0.64090718
138ESR1_20079471_ChIP-ChIP_T-47D_Human0.62637933
139KDM2B_26808549_Chip-Seq_K562_Human0.62392583
140* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.61768427
141* RARA_24833708_ChIP-Seq_LIVER_Mouse0.61673404
142* RARB_24833708_ChIP-Seq_LIVER_Mouse0.61575957

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.11738243
2MP0005360_urolithiasis6.21133504
3MP0005365_abnormal_bile_salt5.31812874
4MP0005085_abnormal_gallbladder_physiolo5.12245834
5MP0008875_abnormal_xenobiotic_pharmacok3.88898872
6MP0010329_abnormal_lipoprotein_level3.67148739
7MP0009840_abnormal_foam_cell3.58065940
8MP0000566_synostosis3.34977682
9MP0003806_abnormal_nucleotide_metabolis3.30958262
10MP0003252_abnormal_bile_duct3.24933342
11MP0005083_abnormal_biliary_tract3.08031967
12MP0003705_abnormal_hypodermis_morpholog2.68994976
13MP0004858_abnormal_nervous_system2.68482317
14MP0003191_abnormal_cellular_cholesterol2.48641660
15MP0005409_darkened_coat_color2.47105216
16MP0001666_abnormal_nutrient_absorption2.39034853
17MP0005332_abnormal_amino_acid2.34427377
18* MP0002118_abnormal_lipid_homeostasis2.23710032
19* MP0000609_abnormal_liver_physiology2.23059069
20MP0005670_abnormal_white_adipose2.22315694
21MP0002254_reproductive_system_inflammat2.02269100
22MP0003195_calcinosis2.00869028
23MP0002249_abnormal_larynx_morphology1.93868623
24MP0000678_abnormal_parathyroid_gland1.92179334
25MP0008260_abnormal_autophagy1.81608859
26MP0004381_abnormal_hair_follicle1.81470196
27MP0004019_abnormal_vitamin_homeostasis1.77455816
28MP0004130_abnormal_muscle_cell1.75506767
29MP0003172_abnormal_lysosome_physiology1.73958353
30MP0002098_abnormal_vibrissa_morphology1.72155541
31MP0005319_abnormal_enzyme/_coenzyme1.67865741
32MP0002877_abnormal_melanocyte_morpholog1.62184914
33MP0005666_abnormal_adipose_tissue1.62046703
34MP0000467_abnormal_esophagus_morphology1.58275558
35MP0005257_abnormal_intraocular_pressure1.55489807
36MP0010234_abnormal_vibrissa_follicle1.50183193
37MP0001348_abnormal_lacrimal_gland1.41821593
38MP0005584_abnormal_enzyme/coenzyme_acti1.41670286
39MP0003300_gastrointestinal_ulcer1.40093937
40MP0004185_abnormal_adipocyte_glucose1.38175793
41MP0003868_abnormal_feces_composition1.37980917
42MP0000537_abnormal_urethra_morphology1.35354062
43MP0003123_paternal_imprinting1.34093224
44MP0009643_abnormal_urine_homeostasis1.32661053
45MP0002138_abnormal_hepatobiliary_system1.31161719
46MP0004233_abnormal_muscle_weight1.30323174
47MP0002089_abnormal_postnatal_growth/wei1.30015689
48MP0004782_abnormal_surfactant_physiolog1.29307609
49MP0002971_abnormal_brown_adipose1.28063490
50MP0003011_delayed_dark_adaptation1.27938724
51MP0001881_abnormal_mammary_gland1.27665753
52MP0000751_myopathy1.22721867
53MP0010030_abnormal_orbit_morphology1.21383561
54MP0000598_abnormal_liver_morphology1.17343516
55MP0008438_abnormal_cutaneous_collagen1.15463680
56MP0000604_amyloidosis1.13633787
57MP0005334_abnormal_fat_pad1.13411336
58MP0009931_abnormal_skin_appearance1.10882868
59MP0003186_abnormal_redox_activity1.09301645
60MP0005375_adipose_tissue_phenotype1.08877924
61MP0000462_abnormal_digestive_system1.06302589
62MP0010678_abnormal_skin_adnexa1.05264663
63MP0002796_impaired_skin_barrier1.04769828
64MP0001764_abnormal_homeostasis1.04668210
65MP0010771_integument_phenotype1.00798935
66MP0003091_abnormal_cell_migration0.98163854
67MP0003690_abnormal_glial_cell0.97595145
68MP0002078_abnormal_glucose_homeostasis0.97208403
69MP0005647_abnormal_sex_gland0.97138479
70MP0006138_congestive_heart_failure0.97067339
71MP0003656_abnormal_erythrocyte_physiolo0.96707234
72MP0002896_abnormal_bone_mineralization0.95450985
73MP0000858_altered_metastatic_potential0.95047369
74MP0001873_stomach_inflammation0.94085671
75MP0003879_abnormal_hair_cell0.93316990
76MP0003115_abnormal_respiratory_system0.90846857
77MP0005275_abnormal_skin_tensile0.89198548
78MP0009115_abnormal_fat_cell0.88954880
79MP0009763_increased_sensitivity_to0.88423211
80MP0002060_abnormal_skin_morphology0.86074810
81MP0002970_abnormal_white_adipose0.85964703
82MP0003329_amyloid_beta_deposits0.84739705
83MP0005220_abnormal_exocrine_pancreas0.84467246
84MP0000762_abnormal_tongue_morphology0.82730427
85MP0001661_extended_life_span0.82461083
86MP0000627_abnormal_mammary_gland0.82036199
87MP0005451_abnormal_body_composition0.78983181
88MP0003942_abnormal_urinary_system0.78775517
89MP0009764_decreased_sensitivity_to0.78191924
90* MP0009642_abnormal_blood_homeostasis0.76946328
91MP0005448_abnormal_energy_balance0.76864084
92MP0000733_abnormal_muscle_development0.76723503
93MP0000747_muscle_weakness0.74490200
94MP0009278_abnormal_bone_marrow0.74240660
95MP0003283_abnormal_digestive_organ0.74023340
96MP0010630_abnormal_cardiac_muscle0.73671065
97MP0003566_abnormal_cell_adhesion0.73632977
98MP0000383_abnormal_hair_follicle0.72999571
99MP0004264_abnormal_extraembryonic_tissu0.71773249
100MP0008469_abnormal_protein_level0.71465900
101MP0003453_abnormal_keratinocyte_physiol0.70822488
102MP0003634_abnormal_glial_cell0.69222363
103MP0009384_cardiac_valve_regurgitation0.67717920
104MP0005636_abnormal_mineral_homeostasis0.66742440
105MP0001756_abnormal_urination0.66526320
106MP0003075_altered_response_to0.65441062
107MP0010368_abnormal_lymphatic_system0.65398990
108MP0005621_abnormal_cell_physiology0.64528037
109MP0000538_abnormal_urinary_bladder0.63675790
110MP0005058_abnormal_lysosome_morphology0.63545076
111MP0005508_abnormal_skeleton_morphology0.63285643
112MP0005535_abnormal_body_temperature0.62892827
113MP0000003_abnormal_adipose_tissue0.62754910
114MP0001958_emphysema0.62501218
115MP0001664_abnormal_digestion0.61390954
116MP0002168_other_aberrant_phenotype0.60945995
117MP0000639_abnormal_adrenal_gland0.60257413
118MP0000470_abnormal_stomach_morphology0.60040712
119MP0005023_abnormal_wound_healing0.59761423
120MP0008961_abnormal_basal_metabolism0.59581890
121MP0001765_abnormal_ion_homeostasis0.58984274
122MP0000367_abnormal_coat/_hair0.58896937
123MP0000477_abnormal_intestine_morphology0.58760511
124MP0000534_abnormal_ureter_morphology0.58276190
125MP0001243_abnormal_dermal_layer0.55798195
126MP0002136_abnormal_kidney_physiology0.53911603
127MP0005376_homeostasis/metabolism_phenot0.53909061
128MP0004947_skin_inflammation0.53378827
129MP0005408_hypopigmentation0.52702153
130MP0009672_abnormal_birth_weight0.52647138
131MP0000579_abnormal_nail_morphology0.52549001
132MP0002909_abnormal_adrenal_gland0.51237658
133MP0009765_abnormal_xenobiotic_induced0.50895963
134MP0009780_abnormal_chondrocyte_physiolo0.50831825
135MP0005464_abnormal_platelet_physiology0.50561072
136MP0003959_abnormal_lean_body0.50533906
137MP0009053_abnormal_anal_canal0.50525174
138MP0006036_abnormal_mitochondrial_physio0.50414126
139MP0001849_ear_inflammation0.50374060
140MP0005248_abnormal_Harderian_gland0.49613138
141MP0003953_abnormal_hormone_level0.49459649
142MP0005076_abnormal_cell_differentiation0.47303535
143MP0001853_heart_inflammation0.45633960
144MP0005501_abnormal_skin_physiology0.44563958
145MP0001944_abnormal_pancreas_morphology0.44498503
146MP0005167_abnormal_blood-brain_barrier0.43810532
147MP0000249_abnormal_blood_vessel0.43603983
148MP0004272_abnormal_basement_membrane0.43220937
149MP0001216_abnormal_epidermal_layer0.41766803
150MP0000377_abnormal_hair_follicle0.40975038
151MP0010352_gastrointestinal_tract_polyps0.40342367

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.61801826
2Intrahepatic cholestasis (HP:0001406)6.11181148
3Xanthomatosis (HP:0000991)6.08225069
4Abnormality of aromatic amino acid family metabolism (HP:0004338)5.99946463
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.60026845
6Hyperlipoproteinemia (HP:0010980)5.11284708
7Hypobetalipoproteinemia (HP:0003563)5.09687744
8Prolonged partial thromboplastin time (HP:0003645)4.84605835
9Complement deficiency (HP:0004431)4.79085983
10Hypolipoproteinemia (HP:0010981)4.36871904
11Hyperglycinuria (HP:0003108)4.32661691
12Hypoalphalipoproteinemia (HP:0003233)4.31363454
13Epidermoid cyst (HP:0200040)4.29888121
14Hypoglycemic coma (HP:0001325)4.28000904
15Ketosis (HP:0001946)4.27030056
16Hyperammonemia (HP:0001987)4.24400286
17Abnormality of serine family amino acid metabolism (HP:0010894)4.10070566
18Abnormality of glycine metabolism (HP:0010895)4.10070566
19Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.02828359
20Hyperglycinemia (HP:0002154)3.94268230
21Abnormality of the common coagulation pathway (HP:0010990)3.88361720
22Abnormality of glutamine family amino acid metabolism (HP:0010902)3.80407847
23Broad face (HP:0000283)3.71616447
24Joint hemorrhage (HP:0005261)3.63399326
25Hyperacusis (HP:0010780)3.59734138
26Hypercholesterolemia (HP:0003124)3.58157627
27Abnormality of sulfur amino acid metabolism (HP:0004339)3.55678153
28Ketoacidosis (HP:0001993)3.55252218
29Abnormality of complement system (HP:0005339)3.52439798
30Myocardial infarction (HP:0001658)3.50678559
31Abnormality of the intrinsic pathway (HP:0010989)3.33752218
32Fat malabsorption (HP:0002630)3.33609525
33Obstructive sleep apnea (HP:0002870)3.32963950
34J-shaped sella turcica (HP:0002680)3.32179770
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.26094230
36Abnormality of fatty-acid metabolism (HP:0004359)3.13672220
37Abnormality of methionine metabolism (HP:0010901)2.99558818
38Cerebral aneurysm (HP:0004944)2.98476191
39Abnormality of aspartate family amino acid metabolism (HP:0010899)2.98017725
40Thin bony cortex (HP:0002753)2.96775288
41Skin nodule (HP:0200036)2.90469032
42Distal lower limb amyotrophy (HP:0008944)2.89271492
43Easy fatigability (HP:0003388)2.85641745
44Hypoglycemic seizures (HP:0002173)2.84183960
45Stridor (HP:0010307)2.82736545
46Distal upper limb amyotrophy (HP:0007149)2.82586721
47Upper limb amyotrophy (HP:0009129)2.82586721
48Spastic diplegia (HP:0001264)2.74708291
49Advanced eruption of teeth (HP:0006288)2.72499003
50Ulnar bowing (HP:0003031)2.70564426
51Abnormality of purine metabolism (HP:0004352)2.69912084
52Cervical subluxation (HP:0003308)2.69421705
53Hepatocellular carcinoma (HP:0001402)2.68590178
54Hyperbilirubinemia (HP:0002904)2.68510295
55Abnormality of nucleobase metabolism (HP:0010932)2.68295007
56Abnormality of pyrimidine metabolism (HP:0004353)2.65060852
57Increased connective tissue (HP:0009025)2.62956444
58Conjugated hyperbilirubinemia (HP:0002908)2.57775789
59Esophageal varix (HP:0002040)2.56454213
60Septate vagina (HP:0001153)2.56004568
61Hemorrhage of the eye (HP:0011885)2.54936554
62Fragile skin (HP:0001030)2.53098725
63Flat acetabular roof (HP:0003180)2.51211820
64Protrusio acetabuli (HP:0003179)2.49114699
65Hydroxyprolinuria (HP:0003080)2.47958382
66Abnormality of proline metabolism (HP:0010907)2.47958382
67Delayed CNS myelination (HP:0002188)2.47237444
68Late onset (HP:0003584)2.46014293
69Mildly elevated creatine phosphokinase (HP:0008180)2.43556714
70Turricephaly (HP:0000262)2.43130836
71Shallow orbits (HP:0000586)2.42973647
72Hyperinsulinemic hypoglycemia (HP:0000825)2.42022368
73Steatorrhea (HP:0002570)2.37935496
74Hypertriglyceridemia (HP:0002155)2.37454210
75Premature rupture of membranes (HP:0001788)2.36616968
76Abnormality of dicarboxylic acid metabolism (HP:0010995)2.34691593
77Dicarboxylic aciduria (HP:0003215)2.34691593
78Abnormality of serum amino acid levels (HP:0003112)2.33793400
79Achilles tendon contracture (HP:0001771)2.33002745
80Distal lower limb muscle weakness (HP:0009053)2.32596186
81Mitral stenosis (HP:0001718)2.29816513
82Pili torti (HP:0003777)2.28963720
83Back pain (HP:0003418)2.26545493
84Vascular calcification (HP:0004934)2.26223388
85Bronchomalacia (HP:0002780)2.25155957
86Abnormal cartilage morphology (HP:0002763)2.24827838
87Lymphangioma (HP:0100764)2.24585926
88Cerebral inclusion bodies (HP:0100314)2.21382745
89Amyloidosis (HP:0011034)2.20829212
90Systemic lupus erythematosus (HP:0002725)2.19846962
91Short nail (HP:0001799)2.19039064
92Gout (HP:0001997)2.17889391
93Metabolic acidosis (HP:0001942)2.14841535
94Abnormal gallbladder morphology (HP:0012437)2.14074097
95Vertebral compression fractures (HP:0002953)2.14004637
96Long palpebral fissure (HP:0000637)2.13805819
97Cardiovascular calcification (HP:0011915)2.12498210
98Axonal loss (HP:0003447)2.11987330
99Acanthocytosis (HP:0001927)2.10103225
100Cholelithiasis (HP:0001081)2.09854569
101Pseudobulbar signs (HP:0002200)2.09371546
102Hyperparathyroidism (HP:0000843)2.08770019
103Atrophic scars (HP:0001075)2.08439280
104Malnutrition (HP:0004395)2.07975319
105Hyperglycemia (HP:0003074)2.07808915
106Hypochromic microcytic anemia (HP:0004840)2.06990050
107Sparse lateral eyebrow (HP:0005338)2.06423532
108Pancreatitis (HP:0001733)2.05526576
109Germ cell neoplasia (HP:0100728)2.04835087
110Neonatal onset (HP:0003623)2.04820275
111Irritability (HP:0000737)2.04394767
112Milia (HP:0001056)1.99101022
113Hyperthyroidism (HP:0000836)1.97628160
114Abnormality of the thoracic spine (HP:0100711)1.97350198
115Brushfield spots (HP:0001088)1.96938929
116Abnormal hair laboratory examination (HP:0003328)1.96592357
117Pterygium (HP:0001059)1.95536063
118Deformed sella turcica (HP:0002681)1.95102418
119Myoglobinuria (HP:0002913)1.93983036
120Abnormality of the distal phalanges of the toes (HP:0010182)1.93808662
121Spontaneous abortion (HP:0005268)1.93302640
122Bulbar palsy (HP:0001283)1.91912092
123Mitral regurgitation (HP:0001653)1.90983512
124Polycythemia (HP:0001901)1.90331238
125Nephritis (HP:0000123)1.89666079
126Biconcave vertebral bodies (HP:0004586)1.89419482
127Abnormality of the Achilles tendon (HP:0005109)1.88210805
128Disproportionate tall stature (HP:0001519)1.88012917
129Precocious puberty (HP:0000826)1.87627259
130Neurofibrillary tangles (HP:0002185)1.87555513
131Lethargy (HP:0001254)1.87532308
132Abnormal gallbladder physiology (HP:0012438)1.87423039
133Cholecystitis (HP:0001082)1.87423039
134Increased mean platelet volume (HP:0011877)1.87032484
135Glomerulonephritis (HP:0000099)1.86802672
136Hypercortisolism (HP:0001578)1.86620423
137Acanthosis nigricans (HP:0000956)1.86304592
138Abnormality of transition element cation homeostasis (HP:0011030)1.85405305
139Abdominal distention (HP:0003270)1.85153548
140Nuclear cataract (HP:0100018)1.84772457
141Hand muscle atrophy (HP:0009130)1.84665367
142Insulin resistance (HP:0000855)1.84598266
143Sensorimotor neuropathy (HP:0007141)1.84328133
144Right ventricular cardiomyopathy (HP:0011663)1.82462830
145Menorrhagia (HP:0000132)1.82127034
146Gingival bleeding (HP:0000225)1.82028293
147Diaphragmatic weakness (HP:0009113)1.81395790
148Abnormality of iron homeostasis (HP:0011031)1.80715604
149Alopecia of scalp (HP:0002293)1.80177572
150Asymmetry of the thorax (HP:0001555)1.80138612
151Aplasia involving bones of the upper limbs (HP:0009823)1.79574778
152Aplasia of the phalanges of the hand (HP:0009802)1.79574778
153Aplasia involving bones of the extremities (HP:0009825)1.79574778
154Urinary glycosaminoglycan excretion (HP:0003541)1.79527915
155Mucopolysacchariduria (HP:0008155)1.79527915
156Dysostosis multiplex (HP:0000943)1.76852321
157Aneurysm (HP:0002617)1.76709869
158Abnormality of the gastric mucosa (HP:0004295)1.76031659
159Symptomatic seizures (HP:0011145)1.75505659
160Lower limb amyotrophy (HP:0007210)1.74957993
161Abnormality of the pancreatic islet cells (HP:0006476)1.74531695
162Abnormality of endocrine pancreas physiology (HP:0012093)1.74531695
163Testicular atrophy (HP:0000029)1.74413176
164Growth hormone excess (HP:0000845)1.74217408
165Blue sclerae (HP:0000592)1.74076684
166Reticulocytosis (HP:0001923)1.72537397
167Stroke (HP:0001297)1.71888961
168Spinal cord compression (HP:0002176)1.70421373
169Difficulty climbing stairs (HP:0003551)1.70384837
170Ectopia lentis (HP:0001083)1.70297446
171Abnormality of mucopolysaccharide metabolism (HP:0011020)1.70139712
172Abnormality of polysaccharide metabolism (HP:0011012)1.70139712
173Abnormality of glycosaminoglycan metabolism (HP:0004371)1.70139712
174Increased cerebral lipofuscin (HP:0011813)1.69665369
175Insomnia (HP:0100785)1.69569293
176Myopathic facies (HP:0002058)1.68439064
177Neonatal death (HP:0003811)1.67188989
178Premature skin wrinkling (HP:0100678)1.67175918
179Increased neuronal autofluorescent lipopigment (HP:0002074)1.67088828
180Bowel incontinence (HP:0002607)1.66488482
181Atelectasis (HP:0100750)1.65542915
182Abnormality of the distal phalanx of the thumb (HP:0009617)1.65489387
183Focal segmental glomerulosclerosis (HP:0000097)1.65257681
184Patellar dislocation (HP:0002999)1.64288856
185Natal tooth (HP:0000695)1.63879622
186Progressive sensorineural hearing impairment (HP:0000408)1.62045110
187Fragile nails (HP:0001808)1.61850488

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.94744315
2BCKDK4.35732142
3ERN14.32635774
4PKN23.50642843
5FGFR43.28973084
6SMG13.15439690
7CAMK1D2.98102428
8EEF2K2.32872779
9* SIK12.21088517
10PTK62.18031123
11CAMK1G2.15038669
12PRPF4B2.07160281
13RIPK12.03992484
14FLT31.92708890
15MAP3K101.85411273
16LATS11.83094855
17INSRR1.79939564
18EPHB11.73069634
19PRKD31.66534653
20MST1R1.48132045
21PDGFRA1.47260686
22TAOK31.45822180
23PAK41.35424323
24EPHA31.33856604
25TESK11.25697178
26MET1.23725959
27PRKD21.22652012
28FGFR31.22474738
29FGFR21.21339190
30MAPK111.20898512
31LMTK21.20187072
32BMX1.19601230
33MARK21.18960012
34CDK61.18802448
35NME21.17686217
36LRRK21.16593559
37TYK21.14965739
38RPS6KB21.14946563
39MAP3K71.11939935
40IRAK21.10965414
41JAK21.10284542
42PRKAA21.08457151
43JAK11.08255407
44PTK21.07908412
45MAP3K61.07254324
46ERBB41.05684477
47RET1.02247638
48TNK21.01713193
49MTOR1.01492803
50ICK0.99726364
51RPS6KA20.99062044
52JAK30.94669768
53TTN0.94286185
54DYRK1B0.93357883
55GRK60.91825542
56MAPK150.90467205
57MAP2K30.85368099
58MUSK0.84421119
59CDC42BPA0.83052070
60KDR0.82613654
61CDK120.81499322
62ERBB20.81152596
63FRK0.79938266
64PIK3CG0.79344991
65EPHA20.78878237
66TAOK20.77958500
67LATS20.77189526
68NEK90.76898687
69TGFBR20.75940867
70MAP3K30.74721676
71PRKCI0.74432281
72TBK10.73712434
73FER0.73325994
74PDGFRB0.72459616
75MAP4K10.72275873
76GSK3A0.71429898
77RPS6KC10.68891359
78RPS6KL10.68891359
79PRKG20.67256588
80FGFR10.66331035
81MAP3K130.65710506
82ZAP700.65681763
83PAK20.65515743
84CDK70.64618641
85EPHB20.64413292
86DAPK20.64109560
87DDR20.63836929
88CSK0.63756220
89IRAK40.62190153
90CDK40.61781145
91ARAF0.61434638
92MAP3K20.60584636
93CSF1R0.60087584
94SIK20.59876924
95STK100.59809981
96PRKAA10.58069234
97MAP2K20.57660857
98SCYL20.53650687
99PRKD10.48955895
100RPS6KA60.48784159
101PRKCH0.47420855
102TYRO30.46691024
103STK380.46295256
104PRKACG0.45987365
105IGF1R0.45530929
106MAP2K10.45422971
107SGK30.45340997
108PHKG10.45093474
109PHKG20.45093474
110MAPKAPK30.43722882
111HIPK20.43116135
112PDPK10.43098358
113NTRK10.42336395
114MAP3K10.41503500
115MAP2K60.40793430
116ILK0.40623248
117PIM20.40580411
118MAP2K40.40571639
119MAPK120.39680910
120MAP3K90.39449371
121MAP3K80.38974086
122CHUK0.38969986
123NEK60.38531464
124CAMKK10.38416662
125PDK30.37879956
126PDK40.37879956
127TESK20.36910279
128PIK3CA0.36848027
129MAPKAPK20.35248325
130IRAK10.34753548
131MAPK40.34638304
132IRAK30.34431264
133PRKCZ0.34283991
134RPS6KA10.34094874
135MATK0.33869554
136KSR20.33644997
137TAOK10.33328840
138EGFR0.33284775
139MAP3K110.33063102
140ABL20.32708317
141BTK0.32489799
142STK30.32283296
143BRAF0.31864538
144SIK30.31804163
145CAMK2B0.30380397
146PDK10.29924107
147CAMK2G0.28512419
148NME10.28453713

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.87536556
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.76340049
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.04264264
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.83482053
5Fatty acid degradation_Homo sapiens_hsa000712.80430035
6Arginine biosynthesis_Homo sapiens_hsa002202.74966400
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.65490904
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.61742297
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.55989749
10Other glycan degradation_Homo sapiens_hsa005112.49878567
11Tryptophan metabolism_Homo sapiens_hsa003802.49058838
12Fatty acid metabolism_Homo sapiens_hsa012122.46910324
13PPAR signaling pathway_Homo sapiens_hsa033202.36680023
14Complement and coagulation cascades_Homo sapiens_hsa046102.36464093
15Propanoate metabolism_Homo sapiens_hsa006402.31436713
16Notch signaling pathway_Homo sapiens_hsa043302.24612040
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.23540319
18Caffeine metabolism_Homo sapiens_hsa002322.11126814
19Fatty acid biosynthesis_Homo sapiens_hsa000612.01772241
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.97766053
21Butanoate metabolism_Homo sapiens_hsa006501.97324162
22Peroxisome_Homo sapiens_hsa041461.88153461
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.77112009
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.73234366
25beta-Alanine metabolism_Homo sapiens_hsa004101.65489546
26Histidine metabolism_Homo sapiens_hsa003401.61567379
27Chemical carcinogenesis_Homo sapiens_hsa052041.60638331
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.58924418
29Chronic myeloid leukemia_Homo sapiens_hsa052201.57159033
30Selenocompound metabolism_Homo sapiens_hsa004501.56086188
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.55851608
32Staphylococcus aureus infection_Homo sapiens_hsa051501.55339642
33Pyruvate metabolism_Homo sapiens_hsa006201.53436628
34Bile secretion_Homo sapiens_hsa049761.48188557
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.47694081
36VEGF signaling pathway_Homo sapiens_hsa043701.46086124
37Fat digestion and absorption_Homo sapiens_hsa049751.45324393
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.42923247
39Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.42752142
40Phenylalanine metabolism_Homo sapiens_hsa003601.37827256
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.33243960
42Carbon metabolism_Homo sapiens_hsa012001.32544719
43Retinol metabolism_Homo sapiens_hsa008301.32490360
44Endometrial cancer_Homo sapiens_hsa052131.31543407
45Sulfur metabolism_Homo sapiens_hsa009201.30532607
46ABC transporters_Homo sapiens_hsa020101.28922996
47Starch and sucrose metabolism_Homo sapiens_hsa005001.28752253
48Non-small cell lung cancer_Homo sapiens_hsa052231.27513244
49Biosynthesis of amino acids_Homo sapiens_hsa012301.27090389
50Fatty acid elongation_Homo sapiens_hsa000621.25317731
51Tyrosine metabolism_Homo sapiens_hsa003501.24535820
52Thyroid cancer_Homo sapiens_hsa052161.22251544
53Thyroid hormone signaling pathway_Homo sapiens_hsa049191.19373305
54Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.19141939
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.14080651
56Maturity onset diabetes of the young_Homo sapiens_hsa049501.14024104
57Lysine degradation_Homo sapiens_hsa003101.10425084
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.08627325
59ErbB signaling pathway_Homo sapiens_hsa040121.08552009
60Glycerolipid metabolism_Homo sapiens_hsa005611.08503912
61Steroid biosynthesis_Homo sapiens_hsa001000.99569698
62Renal cell carcinoma_Homo sapiens_hsa052110.96882202
63Folate biosynthesis_Homo sapiens_hsa007900.96552895
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.96211287
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.94058273
66Pancreatic cancer_Homo sapiens_hsa052120.93194999
67Focal adhesion_Homo sapiens_hsa045100.92926736
68Sulfur relay system_Homo sapiens_hsa041220.92678791
69Estrogen signaling pathway_Homo sapiens_hsa049150.91840735
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.87091683
71Glioma_Homo sapiens_hsa052140.86309415
72GnRH signaling pathway_Homo sapiens_hsa049120.83821570
73Cyanoamino acid metabolism_Homo sapiens_hsa004600.83250981
74Choline metabolism in cancer_Homo sapiens_hsa052310.82876177
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81984697
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.80912577
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80487584
78Aldosterone synthesis and secretion_Homo sapiens_hsa049250.80170330
79Arginine and proline metabolism_Homo sapiens_hsa003300.79691310
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77858628
81Pentose phosphate pathway_Homo sapiens_hsa000300.77834065
82Vibrio cholerae infection_Homo sapiens_hsa051100.76101367
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.75931306
84Inositol phosphate metabolism_Homo sapiens_hsa005620.74854732
85Prostate cancer_Homo sapiens_hsa052150.74398589
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.73658375
87Vitamin B6 metabolism_Homo sapiens_hsa007500.72098424
88Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71789389
89Vitamin digestion and absorption_Homo sapiens_hsa049770.68271013
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67614291
91* Insulin resistance_Homo sapiens_hsa049310.66512254
92Axon guidance_Homo sapiens_hsa043600.62564429
93MicroRNAs in cancer_Homo sapiens_hsa052060.62242882
94One carbon pool by folate_Homo sapiens_hsa006700.62169554
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62014049
96Ovarian steroidogenesis_Homo sapiens_hsa049130.60701285
97Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.60683044
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60493611
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56701070
100N-Glycan biosynthesis_Homo sapiens_hsa005100.54569341
101Adherens junction_Homo sapiens_hsa045200.54558448
102Galactose metabolism_Homo sapiens_hsa000520.54126103
103Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.53855095
104Endocytosis_Homo sapiens_hsa041440.53763589
105Tight junction_Homo sapiens_hsa045300.53414883
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52315809
107Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50063959
108Sphingolipid metabolism_Homo sapiens_hsa006000.47809849
109Leukocyte transendothelial migration_Homo sapiens_hsa046700.47769617
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47362885
111Glutathione metabolism_Homo sapiens_hsa004800.46381488
112Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42941724
113* AMPK signaling pathway_Homo sapiens_hsa041520.42618045
114Melanogenesis_Homo sapiens_hsa049160.42041209
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.38756958
116Fructose and mannose metabolism_Homo sapiens_hsa000510.34798640
117Glucagon signaling pathway_Homo sapiens_hsa049220.34200025
118Central carbon metabolism in cancer_Homo sapiens_hsa052300.31988977
119Prion diseases_Homo sapiens_hsa050200.31206686
120alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30332826
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.30113253
122Metabolic pathways_Homo sapiens_hsa011000.28586125
123* Insulin signaling pathway_Homo sapiens_hsa049100.24574975
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.24187092
125Bladder cancer_Homo sapiens_hsa052190.18443622
126Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.14849596
127Linoleic acid metabolism_Homo sapiens_hsa005910.06638284
128Longevity regulating pathway - mammal_Homo sapiens_hsa042110.06530191
129Carbohydrate digestion and absorption_Homo sapiens_hsa049730.05805714
130Protein digestion and absorption_Homo sapiens_hsa049740.05095395
131Amoebiasis_Homo sapiens_hsa051460.04840688
132Type II diabetes mellitus_Homo sapiens_hsa049300.02194899
133Acute myeloid leukemia_Homo sapiens_hsa052210.01644426
134Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.01255136
135Glycosaminoglycan degradation_Homo sapiens_hsa005310.01251339
136Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0657340
137Proteoglycans in cancer_Homo sapiens_hsa05205-0.0651877
138Small cell lung cancer_Homo sapiens_hsa05222-0.0603348
139Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0482640
140Hepatitis C_Homo sapiens_hsa05160-0.0448850
141Lysosome_Homo sapiens_hsa04142-0.0442402
142Prolactin signaling pathway_Homo sapiens_hsa04917-0.0386277
143mTOR signaling pathway_Homo sapiens_hsa04150-0.0381179
144ECM-receptor interaction_Homo sapiens_hsa04512-0.0016385

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