SRA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Both long non-coding and protein-coding RNAs are transcribed from this gene, and they represent alternatively spliced transcript variants. This gene was initially defined as a non-coding RNA, which is a coactivator for several nuclear receptors (NRs) and is associated with breast cancer. It has now been found that this gene is involved in the regulation of many NR and non-NR activities, including metabolism, adipogenesis and chromatin organization. The long non-coding RNA transcripts interact with a variety of proteins, including the protein encoded by this gene. The encoded protein acts as a transcriptional repressor by binding to the non-coding RNA. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.40746854
2ATP synthesis coupled proton transport (GO:0015986)6.00804622
3energy coupled proton transport, down electrochemical gradient (GO:0015985)6.00804622
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.89014835
5establishment of protein localization to mitochondrial membrane (GO:0090151)5.56237486
6respiratory electron transport chain (GO:0022904)5.23293824
7electron transport chain (GO:0022900)5.11719383
8negative regulation of ligase activity (GO:0051352)4.77004426
9negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.77004426
10positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.71482886
11signal peptide processing (GO:0006465)4.62998219
12protein complex biogenesis (GO:0070271)4.57001831
13regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.53389354
14signal transduction involved in DNA damage checkpoint (GO:0072422)4.37051433
15signal transduction involved in cell cycle checkpoint (GO:0072395)4.31919261
16anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.20438403
17mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.17594229
18mitochondrial respiratory chain complex I assembly (GO:0032981)4.17594229
19NADH dehydrogenase complex assembly (GO:0010257)4.17594229
20positive regulation of ubiquitin-protein transferase activity (GO:0051443)4.11504125
21chaperone-mediated protein transport (GO:0072321)4.00633488
22aldehyde catabolic process (GO:0046185)4.00560771
23mitochondrial respiratory chain complex assembly (GO:0033108)3.98980683
24positive regulation of ligase activity (GO:0051351)3.93384399
25rRNA modification (GO:0000154)3.93032377
26protein neddylation (GO:0045116)3.90748263
27fatty acid elongation (GO:0030497)3.86391429
28tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.70100108
29RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.70100108
30respiratory chain complex IV assembly (GO:0008535)3.69981458
31regulation of ubiquitin-protein transferase activity (GO:0051438)3.68171691
32erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.67767724
33L-phenylalanine catabolic process (GO:0006559)3.67767724
34proteasome assembly (GO:0043248)3.60421604
35regulation of ligase activity (GO:0051340)3.54786337
36positive regulation of cell cycle arrest (GO:0071158)3.54396790
37erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.50375099
38L-phenylalanine metabolic process (GO:0006558)3.50375099
39DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.46348147
40cytochrome complex assembly (GO:0017004)3.45698286
41regulation of mitochondrial translation (GO:0070129)3.43863175
42GTP biosynthetic process (GO:0006183)3.43062764
43nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.41232218
44negative regulation of protein ubiquitination (GO:0031397)3.39885922
45cytidine deamination (GO:0009972)3.37674749
46cytidine metabolic process (GO:0046087)3.37674749
47cytidine catabolic process (GO:0006216)3.37674749
48exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.27900380
49purine nucleoside triphosphate biosynthetic process (GO:0009145)3.27531880
50hydrogen ion transmembrane transport (GO:1902600)3.27260056
51purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.23467505
52platelet dense granule organization (GO:0060155)3.22646793
53negative regulation of protein modification by small protein conjugation or removal (GO:1903321)3.22421184
54L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.21174513
55deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.20007011
56ATP biosynthetic process (GO:0006754)3.17868859
57cholesterol biosynthetic process (GO:0006695)3.16829193
58rRNA methylation (GO:0031167)3.13469571
59regulation of metalloenzyme activity (GO:0048552)3.13078705
60ribosomal small subunit biogenesis (GO:0042274)3.11697668
61GDP-mannose metabolic process (GO:0019673)3.10741067
62nucleotide transmembrane transport (GO:1901679)3.09454205
63regulation of cellular amino acid metabolic process (GO:0006521)3.07087174
64base-excision repair, AP site formation (GO:0006285)3.06003561
65cellular ketone body metabolic process (GO:0046950)3.03940881
66proton transport (GO:0015992)3.02890891
67pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.01182140
68pyrimidine-containing compound transmembrane transport (GO:0072531)3.00006381
69antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.98815945
70hydrogen transport (GO:0006818)2.98502973
71regulation of cell cycle arrest (GO:0071156)2.98167215
72pseudouridine synthesis (GO:0001522)2.95547618
73inner mitochondrial membrane organization (GO:0007007)2.95060937
74signal transduction in response to DNA damage (GO:0042770)2.94636383
75cofactor catabolic process (GO:0051187)2.93886568
76aromatic amino acid family catabolic process (GO:0009074)2.91032995
77L-methionine salvage (GO:0071267)2.89780819
78L-methionine biosynthetic process (GO:0071265)2.89780819
79amino acid salvage (GO:0043102)2.89780819
80ribosomal small subunit assembly (GO:0000028)2.88025453
81negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)2.86714498
82negative regulation of cell cycle G1/S phase transition (GO:1902807)2.86714498
83cellular response to zinc ion (GO:0071294)2.86486487
84mitochondrial transport (GO:0006839)2.85460226
85translation (GO:0006412)2.84829632
86basic amino acid transport (GO:0015802)2.84748440
87sterol biosynthetic process (GO:0016126)2.84483685
88antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.84397328
89regulation of oxidative phosphorylation (GO:0002082)2.81724671
90neutrophil activation involved in immune response (GO:0002283)2.81672363
91peptidyl-histidine modification (GO:0018202)2.81378716
92metallo-sulfur cluster assembly (GO:0031163)2.80812910
93iron-sulfur cluster assembly (GO:0016226)2.80812910
94ribonucleoside triphosphate biosynthetic process (GO:0009201)2.77764310
95water-soluble vitamin biosynthetic process (GO:0042364)2.76891240
96C-terminal protein lipidation (GO:0006501)2.76832996
97dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.76233362
98ATP hydrolysis coupled proton transport (GO:0015991)2.75728222
99energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.75728222
100oxidative phosphorylation (GO:0006119)2.74432102
101termination of RNA polymerase III transcription (GO:0006386)2.72562504
102transcription elongation from RNA polymerase III promoter (GO:0006385)2.72562504
103cellular response to oxygen radical (GO:0071450)2.70442535
104removal of superoxide radicals (GO:0019430)2.70442535
105cellular response to superoxide (GO:0071451)2.70442535
106guanosine-containing compound biosynthetic process (GO:1901070)2.69369851
107DNA deamination (GO:0045006)2.68606487
108protein-cofactor linkage (GO:0018065)2.64167468
109mannosylation (GO:0097502)2.64145354
110axon ensheathment in central nervous system (GO:0032291)2.64086932
111central nervous system myelination (GO:0022010)2.64086932
112ketone body metabolic process (GO:1902224)2.60860214
113regulation of cellular amine metabolic process (GO:0033238)2.60843516
114UTP biosynthetic process (GO:0006228)2.60489439
115protein targeting to mitochondrion (GO:0006626)2.59613075
116GPI anchor biosynthetic process (GO:0006506)2.55178740
117antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.54353784
118establishment of protein localization to mitochondrion (GO:0072655)2.54276623
119DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.49686634
120nucleoside triphosphate biosynthetic process (GO:0009142)2.48240249
121mitochondrion morphogenesis (GO:0070584)2.48044202
122negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.48009805
123positive regulation of protein homodimerization activity (GO:0090073)2.45128803
124dopamine transport (GO:0015872)2.44086745
125UTP metabolic process (GO:0046051)2.43376210
126signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.42503352
127signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.42503352
128signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.42503352
129isoprenoid biosynthetic process (GO:0008299)2.42397034
130intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.42382574
131signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.42382574
132response to redox state (GO:0051775)2.39333199
133cullin deneddylation (GO:0010388)2.39178679
134aerobic respiration (GO:0009060)2.37755696
135CTP biosynthetic process (GO:0006241)2.37717803
136CTP metabolic process (GO:0046036)2.37717803
137protein deneddylation (GO:0000338)2.37257588
138coenzyme catabolic process (GO:0009109)2.36734359
139preassembly of GPI anchor in ER membrane (GO:0016254)2.36533899
140positive regulation of cellular amine metabolic process (GO:0033240)2.35026770
141intracellular protein transmembrane import (GO:0044743)2.34613055
142aromatic amino acid family metabolic process (GO:0009072)2.33345455
143protein localization to mitochondrion (GO:0070585)2.32608220
144positive regulation of mitochondrial fission (GO:0090141)2.32438820
1453-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.31858296
146purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.31858296
147signal transduction involved in DNA integrity checkpoint (GO:0072401)2.31087219

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.75486955
2* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.54931865
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.43890067
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.27644666
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.27050375
6PDX1_19855005_ChIP-ChIP_MIN6_Mouse3.24458029
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.00292402
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.00279342
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.94031762
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.65892029
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.63764009
12* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.57407979
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.55817922
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.55321617
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.54170156
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.42130241
17SRF_21415370_ChIP-Seq_HL-1_Mouse2.41633943
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.22725562
19CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.21360866
20XRN2_22483619_ChIP-Seq_HELA_Human2.15454487
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.10322581
22MYC_19030024_ChIP-ChIP_MESCs_Mouse2.06112639
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.98737828
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.96663904
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.89516328
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.87996098
27CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.84576495
28IRF8_22096565_ChIP-ChIP_GC-B_Human1.81815408
29FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.74789511
30TTF2_22483619_ChIP-Seq_HELA_Human1.74220861
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.72344227
32RXR_22158963_ChIP-Seq_LIVER_Mouse1.68315672
33* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.68287541
34* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.64218507
35BP1_19119308_ChIP-ChIP_Hs578T_Human1.61043200
36ELK1_22589737_ChIP-Seq_MCF10A_Human1.56222858
37VDR_23849224_ChIP-Seq_CD4+_Human1.55374053
38FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.55316097
39* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.50120809
40GBX2_23144817_ChIP-Seq_PC3_Human1.49291855
41STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.44568632
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41515583
43FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.40690529
44HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.37943152
45ETV2_25802403_ChIP-Seq_MESCs_Mouse1.37902918
46VDR_22108803_ChIP-Seq_LS180_Human1.35269025
47PPARA_22158963_ChIP-Seq_LIVER_Mouse1.32286438
48* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.32280360
49BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31716024
50PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.31466233
51MYC_19079543_ChIP-ChIP_MESCs_Mouse1.31285035
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.29337641
53DCP1A_22483619_ChIP-Seq_HELA_Human1.29113245
54TAF15_26573619_Chip-Seq_HEK293_Human1.28952560
55* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.27964104
56* PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.26976453
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.26619872
58PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26326022
59THAP11_20581084_ChIP-Seq_MESCs_Mouse1.25719115
60IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.25571249
61E2F4_17652178_ChIP-ChIP_JURKAT_Human1.25497949
62ELK1_19687146_ChIP-ChIP_HELA_Human1.24757084
63MYC_18940864_ChIP-ChIP_HL60_Human1.22609974
64ZFP57_27257070_Chip-Seq_ESCs_Mouse1.21600469
65* TFEB_21752829_ChIP-Seq_HELA_Human1.20318882
66HTT_18923047_ChIP-ChIP_STHdh_Human1.17979945
67HOXB4_20404135_ChIP-ChIP_EML_Mouse1.17973316
68MYC_18358816_ChIP-ChIP_MESCs_Mouse1.17576510
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16295789
70MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.15717441
71LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.15422599
72IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13758748
73EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.13329297
74PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13083874
75* SPI1_23547873_ChIP-Seq_NB4_Human1.12358802
76* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11765817
77FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.11590413
78CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.11029046
79CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.10994274
80FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.10724973
81YY1_21170310_ChIP-Seq_MESCs_Mouse1.10496578
82E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09770258
83ER_23166858_ChIP-Seq_MCF-7_Human1.09215185
84PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.08364407
85YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05648522
86MYCN_18555785_ChIP-Seq_MESCs_Mouse1.03752307
87DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03000790
88LXR_22158963_ChIP-Seq_LIVER_Mouse1.02583223
89KDM5A_27292631_Chip-Seq_BREAST_Human1.02473300
90ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.01852462
91RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.00775708
92* FOXP1_21924763_ChIP-Seq_HESCs_Human0.99869717
93POU3F2_20337985_ChIP-ChIP_501MEL_Human0.99739115
94ELF5_23300383_ChIP-Seq_T47D_Human0.98973994
95PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97484583
96HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97380601
97IRF1_19129219_ChIP-ChIP_H3396_Human0.97342856
98FLI1_27457419_Chip-Seq_LIVER_Mouse0.97338957
99IRF8_21731497_ChIP-ChIP_J774_Mouse0.97280327
100BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.96308339
101POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.96287895
102ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.95594022
103RAD21_21589869_ChIP-Seq_MESCs_Mouse0.95083784
104ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94887933
105PCGF2_27294783_Chip-Seq_ESCs_Mouse0.93779263
106TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.93575225
107AR_20517297_ChIP-Seq_VCAP_Human0.93458175
108* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93169842
109RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.91863061
110CTCF_18555785_ChIP-Seq_MESCs_Mouse0.90823441
111CIITA_25753668_ChIP-Seq_RAJI_Human0.90604749
112ELF1_20517297_ChIP-Seq_JURKAT_Human0.90524749
113BCL6_27268052_Chip-Seq_Bcells_Human0.89969413
114DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.89731060
115ZNF274_21170338_ChIP-Seq_K562_Hela0.88477309
116POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.88434132
117NANOG_18555785_ChIP-Seq_MESCs_Mouse0.88337726
118* GABP_19822575_ChIP-Seq_HepG2_Human0.88192045
119ERG_20887958_ChIP-Seq_HPC-7_Mouse0.87883616
120EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.87743461
121ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86250002
122CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85400681
123FOXP3_21729870_ChIP-Seq_TREG_Human0.85365527
124STAT1_20625510_ChIP-Seq_HELA_Human0.85277167
125* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.84570252
126CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.84353208
127GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84072054
128* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.83987580
129TP53_22573176_ChIP-Seq_HFKS_Human0.82706038
130TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82444129
131YY1_22570637_ChIP-Seq_MALME-3M_Human0.82008604
132STAT3_18555785_Chip-Seq_ESCs_Mouse0.81803848
133NANOG_19829295_ChIP-Seq_ESCs_Human0.81711041
134SOX2_19829295_ChIP-Seq_ESCs_Human0.81711041
135SOX17_20123909_ChIP-Seq_XEN_Mouse0.79872537
136ERA_21632823_ChIP-Seq_H3396_Human0.79535764
137CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.79011039
138RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.78502112
139TBX5_21415370_ChIP-Seq_HL-1_Mouse0.78146888
140* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.78082548
141* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.78082548
142OCT4_20526341_ChIP-Seq_ESCs_Human0.76575220
143ERG_20517297_ChIP-Seq_VCAP_Human0.76556603
144SRY_22984422_ChIP-ChIP_TESTIS_Rat0.75935223
145TAL1_26923725_Chip-Seq_HPCs_Mouse0.75607268
146RUNX1_27457419_Chip-Seq_LIVER_Mouse0.75451178
147CTCF_26484167_Chip-Seq_Bcells_Mouse0.75401508
148PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.74888026
149SMAD1_18555785_Chip-Seq_ESCs_Mouse0.73476486
150STAT4_19710469_ChIP-ChIP_TH1__Mouse0.73013847
151CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.72715459
152BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.72648331

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.07841798
2MP0002139_abnormal_hepatobiliary_system3.41828152
3MP0003195_calcinosis3.00963176
4MP0005085_abnormal_gallbladder_physiolo2.75037359
5MP0003880_abnormal_central_pattern2.73177154
6MP0001529_abnormal_vocalization2.56423103
7MP0009379_abnormal_foot_pigmentation2.54044701
8MP0003186_abnormal_redox_activity2.44977053
9MP0002254_reproductive_system_inflammat2.43877521
10MP0001905_abnormal_dopamine_level2.43492186
11MP0005365_abnormal_bile_salt2.42544302
12MP0005083_abnormal_biliary_tract2.37351916
13MP0005084_abnormal_gallbladder_morpholo2.37341785
14MP0006054_spinal_hemorrhage2.31877342
15MP0003136_yellow_coat_color2.23822284
16MP0008058_abnormal_DNA_repair2.21454410
17MP0005360_urolithiasis2.14609124
18MP0008875_abnormal_xenobiotic_pharmacok2.12502980
19MP0002876_abnormal_thyroid_physiology2.11753119
20MP0003786_premature_aging2.10716907
21MP0009785_altered_susceptibility_to2.07669949
22MP0002653_abnormal_ependyma_morphology2.01141292
23MP0003724_increased_susceptibility_to2.00479960
24MP0006276_abnormal_autonomic_nervous1.96178498
25MP0004043_abnormal_pH_regulation1.95700113
26MP0002736_abnormal_nociception_after1.92109759
27MP0009697_abnormal_copulation1.90609013
28MP0005379_endocrine/exocrine_gland_phen1.87384443
29MP0001727_abnormal_embryo_implantation1.87373607
30MP0000749_muscle_degeneration1.86400921
31MP0001986_abnormal_taste_sensitivity1.84712354
32MP0005058_abnormal_lysosome_morphology1.83802270
33MP0010386_abnormal_urinary_bladder1.81894836
34MP0005174_abnormal_tail_pigmentation1.79695906
35MP0005075_abnormal_melanosome_morpholog1.79125329
36MP0001764_abnormal_homeostasis1.75065844
37MP0005332_abnormal_amino_acid1.74535989
38MP0001853_heart_inflammation1.65650312
39MP0002638_abnormal_pupillary_reflex1.63005646
40MP0005636_abnormal_mineral_homeostasis1.62402135
41MP0006036_abnormal_mitochondrial_physio1.60913846
42MP0000343_altered_response_to1.60007763
43MP0009333_abnormal_splenocyte_physiolog1.59659968
44MP0004142_abnormal_muscle_tone1.59191341
45MP0003011_delayed_dark_adaptation1.58459377
46MP0001542_abnormal_bone_strength1.56502512
47MP0003693_abnormal_embryo_hatching1.51922782
48MP0008004_abnormal_stomach_pH1.48662188
49MP0001968_abnormal_touch/_nociception1.47442876
50MP0000566_synostosis1.46326804
51MP0005671_abnormal_response_to1.44544740
52MP0006072_abnormal_retinal_apoptosis1.42527906
53MP0002148_abnormal_hypersensitivity_rea1.42183206
54MP0001666_abnormal_nutrient_absorption1.39435246
55MP0002138_abnormal_hepatobiliary_system1.38483705
56MP0003656_abnormal_erythrocyte_physiolo1.35700828
57MP0005410_abnormal_fertilization1.33936363
58MP0002735_abnormal_chemical_nociception1.32934935
59MP0002102_abnormal_ear_morphology1.32391424
60MP0008007_abnormal_cellular_replicative1.32202554
61MP0002132_abnormal_respiratory_system1.30958999
62MP0000358_abnormal_cell_content/1.27293578
63MP0002090_abnormal_vision1.26794180
64MP0004957_abnormal_blastocyst_morpholog1.25820997
65MP0002163_abnormal_gland_morphology1.25139660
66MP0000920_abnormal_myelination1.24911742
67MP0002723_abnormal_immune_serum1.19758871
68MP0001919_abnormal_reproductive_system1.17243014
69MP0003077_abnormal_cell_cycle1.16000286
70MP0002837_dystrophic_cardiac_calcinosis1.15903998
71MP0002452_abnormal_antigen_presenting1.15889631
72MP0000685_abnormal_immune_system1.15392298
73MP0003315_abnormal_perineum_morphology1.15373932
74MP0003191_abnormal_cellular_cholesterol1.15184099
75MP0008260_abnormal_autophagy1.12909867
76MP0001845_abnormal_inflammatory_respons1.10891761
77MP0009643_abnormal_urine_homeostasis1.10630681
78MP0005551_abnormal_eye_electrophysiolog1.10616092
79MP0008877_abnormal_DNA_methylation1.09454887
80MP0006035_abnormal_mitochondrial_morpho1.08531503
81MP0008469_abnormal_protein_level1.08089789
82MP0002272_abnormal_nervous_system1.07442033
83MP0004019_abnormal_vitamin_homeostasis1.07185506
84MP0006082_CNS_inflammation1.07170008
85MP0001501_abnormal_sleep_pattern1.05753129
86MP0000372_irregular_coat_pigmentation1.04721703
87MP0001800_abnormal_humoral_immune1.04238946
88MP0002933_joint_inflammation1.03495952
89MP0005584_abnormal_enzyme/coenzyme_acti1.03491224
90MP0000015_abnormal_ear_pigmentation1.02944352
91MP0008873_increased_physiological_sensi1.02023603
92MP0009764_decreased_sensitivity_to1.01941987
93MP0005535_abnormal_body_temperature1.01840067
94MP0001664_abnormal_digestion1.01481616
95MP0005025_abnormal_response_to1.01410442
96MP0005408_hypopigmentation1.01272089
97MP0002277_abnormal_respiratory_mucosa1.00602911
98MP0002420_abnormal_adaptive_immunity0.99659339
99MP0005000_abnormal_immune_tolerance0.99519937
100MP0004145_abnormal_muscle_electrophysio0.97930946
101MP0000538_abnormal_urinary_bladder0.97434620
102MP0002734_abnormal_mechanical_nocicepti0.97317076
103MP0003868_abnormal_feces_composition0.96705742
104MP0000750_abnormal_muscle_regeneration0.96389077
105MP0001819_abnormal_immune_cell0.96311075
106MP0002419_abnormal_innate_immunity0.95706361
107MP0002118_abnormal_lipid_homeostasis0.94640155
108MP0010094_abnormal_chromosome_stability0.94204269
109MP0003075_altered_response_to0.93520647
110MP0001440_abnormal_grooming_behavior0.92954380
111MP0005253_abnormal_eye_physiology0.90640681
112MP0001835_abnormal_antigen_presentation0.90485031
113MP0004381_abnormal_hair_follicle0.89435728
114MP0001790_abnormal_immune_system0.89317691
115MP0005387_immune_system_phenotype0.89317691
116MP0002693_abnormal_pancreas_physiology0.89040671
117MP0002938_white_spotting0.88932746
118MP0002295_abnormal_pulmonary_circulatio0.87202867
119MP0005646_abnormal_pituitary_gland0.86668459
120MP0001984_abnormal_olfaction0.86290882
121MP0008789_abnormal_olfactory_epithelium0.86226286
122MP0005389_reproductive_system_phenotype0.85975307
123MP0004147_increased_porphyrin_level0.85690590
124MP0003436_decreased_susceptibility_to0.85646481
125MP0002822_catalepsy0.84922481
126MP0008872_abnormal_physiological_respon0.84415068
127MP0005367_renal/urinary_system_phenotyp0.83773943
128MP0000516_abnormal_urinary_system0.83773943
129MP0003111_abnormal_nucleus_morphology0.83261850
130MP0008995_early_reproductive_senescence0.82746656
131MP0001485_abnormal_pinna_reflex0.82257973
132MP0008932_abnormal_embryonic_tissue0.81958691
133MP0009840_abnormal_foam_cell0.81695643
134MP0003959_abnormal_lean_body0.81248887
135MP0005330_cardiomyopathy0.80126518
136MP0000604_amyloidosis0.79570808
137MP0001188_hyperpigmentation0.78525479
138MP0004782_abnormal_surfactant_physiolog0.78243774
139MP0003137_abnormal_impulse_conducting0.78159151
140MP0003718_maternal_effect0.78098266
141MP0005451_abnormal_body_composition0.77902712
142MP0010329_abnormal_lipoprotein_level0.77843771
143MP0001970_abnormal_pain_threshold0.76806776
144MP0009745_abnormal_behavioral_response0.76741680
145MP0005171_absent_coat_pigmentation0.75858574
146MP0005376_homeostasis/metabolism_phenot0.74782747
147MP0005645_abnormal_hypothalamus_physiol0.73647143
148MP0004924_abnormal_behavior0.73456424
149MP0005386_behavior/neurological_phenoty0.73456424
150MP0002160_abnormal_reproductive_system0.73427152
151MP0002405_respiratory_system_inflammati0.72262679
152MP0005381_digestive/alimentary_phenotyp0.71576549
153MP0002064_seizures0.71377984
154MP0002095_abnormal_skin_pigmentation0.70657565

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.26580425
2Abnormal mitochondria in muscle tissue (HP:0008316)5.72599115
3Acute encephalopathy (HP:0006846)5.43357732
4Mitochondrial inheritance (HP:0001427)5.30189009
5Progressive macrocephaly (HP:0004481)5.04625953
6Increased CSF lactate (HP:0002490)4.46145468
7Hepatocellular necrosis (HP:0001404)4.36089616
8Agnosia (HP:0010524)4.28408156
9Hepatic necrosis (HP:0002605)4.13106195
10Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)4.12303319
11Cerebral edema (HP:0002181)4.05768269
12Renal Fanconi syndrome (HP:0001994)3.95752290
13Increased hepatocellular lipid droplets (HP:0006565)3.91328382
14Abnormality of aromatic amino acid family metabolism (HP:0004338)3.78171473
153-Methylglutaconic aciduria (HP:0003535)3.75111951
16Lipid accumulation in hepatocytes (HP:0006561)3.72067980
17Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.60905757
18Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.35147401
19Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.32594311
20Decreased activity of mitochondrial respiratory chain (HP:0008972)3.32594311
21Optic disc pallor (HP:0000543)3.22942929
22Lactic acidosis (HP:0003128)3.18911715
23Increased intramyocellular lipid droplets (HP:0012240)3.18649828
24Exercise intolerance (HP:0003546)3.17737951
25Leukodystrophy (HP:0002415)3.07307914
26Respiratory failure (HP:0002878)3.06406366
27Abnormality of glycolysis (HP:0004366)2.97523489
28Increased serum pyruvate (HP:0003542)2.97523489
29Axonal loss (HP:0003447)2.97518995
30Increased muscle lipid content (HP:0009058)2.89487670
31Disinhibition (HP:0000734)2.89268582
32Increased serum lactate (HP:0002151)2.87717936
33Exertional dyspnea (HP:0002875)2.75560419
34Lethargy (HP:0001254)2.74401026
35Abnormality of renal resorption (HP:0011038)2.73531357
36Aplastic anemia (HP:0001915)2.71326622
37Prolonged partial thromboplastin time (HP:0003645)2.68049414
38Hypothermia (HP:0002045)2.63655273
39Amniotic constriction ring (HP:0009775)2.58811221
40Abnormality of placental membranes (HP:0011409)2.58811221
41Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.55606054
42Abnormal tarsal ossification (HP:0008369)2.50661132
43Neuroendocrine neoplasm (HP:0100634)2.49741280
44Methylmalonic acidemia (HP:0002912)2.48077404
45Glycosuria (HP:0003076)2.47865011
46Abnormality of urine glucose concentration (HP:0011016)2.47865011
47IgM deficiency (HP:0002850)2.43715024
48Hyperphosphaturia (HP:0003109)2.39241074
49Methylmalonic aciduria (HP:0012120)2.37112679
50Aplasia/hypoplasia of the uterus (HP:0008684)2.23814906
51Abnormality of alanine metabolism (HP:0010916)2.20431110
52Hyperalaninemia (HP:0003348)2.20431110
53Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.20431110
54Abnormality of methionine metabolism (HP:0010901)2.19391458
55Poor head control (HP:0002421)2.19007151
56Parakeratosis (HP:0001036)2.17719739
57Congenital ichthyosiform erythroderma (HP:0007431)2.17053653
58Abnormality of dicarboxylic acid metabolism (HP:0010995)2.13112049
59Dicarboxylic aciduria (HP:0003215)2.13112049
60Type I transferrin isoform profile (HP:0003642)2.11386198
61Abnormality of the anterior horn cell (HP:0006802)2.09432845
62Degeneration of anterior horn cells (HP:0002398)2.09432845
63Vomiting (HP:0002013)2.09299050
64CNS demyelination (HP:0007305)2.08491103
65Hypobetalipoproteinemia (HP:0003563)2.07303883
66Upper motor neuron abnormality (HP:0002127)2.06035214
67Progressive external ophthalmoplegia (HP:0000590)2.04829851
68Pheochromocytoma (HP:0002666)2.04168774
69Conjugated hyperbilirubinemia (HP:0002908)2.03688975
70Gliosis (HP:0002171)2.02001370
71Intrahepatic cholestasis (HP:0001406)2.00428402
72Medial flaring of the eyebrow (HP:0010747)1.99571144
73Stomatitis (HP:0010280)1.97680490
74Pancytopenia (HP:0001876)1.97421188
75Personality changes (HP:0000751)1.97409349
76Abnormal urine phosphate concentration (HP:0012599)1.97051771
77Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.96972978
78X-linked dominant inheritance (HP:0001423)1.96032417
79Testicular atrophy (HP:0000029)1.91516774
80Generalized aminoaciduria (HP:0002909)1.91502893
81Renal cortical cysts (HP:0000803)1.91440871
82Respiratory difficulties (HP:0002880)1.90721681
83Progressive microcephaly (HP:0000253)1.90526975
84Nausea (HP:0002018)1.88666329
85Ileus (HP:0002595)1.87540790
86Polyphagia (HP:0002591)1.87385557
87IgG deficiency (HP:0004315)1.86535892
88Oral leukoplakia (HP:0002745)1.86325259
89Absent thumb (HP:0009777)1.85997835
90Recurrent bacterial skin infections (HP:0005406)1.85053521
91Abnormality of monocarboxylic acid metabolism (HP:0010996)1.81331295
92Reduced antithrombin III activity (HP:0001976)1.80770835
93Hypoplasia of the uterus (HP:0000013)1.80552438
94Abnormal number of erythroid precursors (HP:0012131)1.80545644
95Abnormality of aspartate family amino acid metabolism (HP:0010899)1.79841131
96Hypoglycemic coma (HP:0001325)1.79810533
97Fat malabsorption (HP:0002630)1.79782179
98Vacuolated lymphocytes (HP:0001922)1.79452304
99Increased IgM level (HP:0003496)1.78232305
100Decreased electroretinogram (ERG) amplitude (HP:0000654)1.77912999
101Emotional lability (HP:0000712)1.77894349
102Opisthotonus (HP:0002179)1.75420871
103Rough bone trabeculation (HP:0100670)1.75054658
104Poor suck (HP:0002033)1.73954657
105Abnormal pupillary function (HP:0007686)1.73824839
106Atrophy/Degeneration involving motor neurons (HP:0007373)1.73557399
107Steatorrhea (HP:0002570)1.72669699
108Microvesicular hepatic steatosis (HP:0001414)1.72548944
109Abnormal neuron morphology (HP:0012757)1.72544084
110Abnormality of the motor neurons (HP:0002450)1.72544084
111Irregular vertebral endplates (HP:0003301)1.69550308
112Abnormality of fatty-acid metabolism (HP:0004359)1.68608008
113Renal tubular dysfunction (HP:0000124)1.68343335
114Abnormality of glycolipid metabolism (HP:0010969)1.67758859
115Abnormality of liposaccharide metabolism (HP:0010968)1.67758859
116Abnormality of glycosphingolipid metabolism (HP:0004343)1.67758859
117Microretrognathia (HP:0000308)1.67632501
118Congenital, generalized hypertrichosis (HP:0004540)1.65933249
119Pustule (HP:0200039)1.65402304
120Proximal tubulopathy (HP:0000114)1.65029208
121Inappropriate behavior (HP:0000719)1.64675507
122Bone cyst (HP:0012062)1.64559893
123Type 2 muscle fiber atrophy (HP:0003554)1.64338298
124Recurrent abscess formation (HP:0002722)1.64067434
125Neck muscle weakness (HP:0000467)1.64054365
126Chronic bronchitis (HP:0004469)1.63028519
127Congenital sensorineural hearing impairment (HP:0008527)1.62526502
128Hypophosphatemic rickets (HP:0004912)1.61906302
129Abnormal protein glycosylation (HP:0012346)1.61574854
130Abnormal glycosylation (HP:0012345)1.61574854
131Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.61574854
132Abnormal protein N-linked glycosylation (HP:0012347)1.61574854
133Prolonged neonatal jaundice (HP:0006579)1.60090852
134Enlarged kidneys (HP:0000105)1.59701212
135Metabolic acidosis (HP:0001942)1.57725808
136Brushfield spots (HP:0001088)1.57207330
137Hyperventilation (HP:0002883)1.56886028
138Abnormality of the heme biosynthetic pathway (HP:0010472)1.56383351
139Cerebral hypomyelination (HP:0006808)1.55028329
140True hermaphroditism (HP:0010459)1.53838904
141Abnormal hemoglobin (HP:0011902)1.53707711
142Abnormal gallbladder physiology (HP:0012438)1.52230849
143Cholecystitis (HP:0001082)1.52230849
144Xanthomatosis (HP:0000991)1.51994911

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK163.66550129
2VRK23.61804066
3PBK3.41530207
4PDK22.37558306
5NME22.35976157
6EIF2AK32.33144426
7NME12.32861487
8BUB12.22151631
9CASK2.16448311
10BCKDK2.15164643
11MAPK152.12658895
12STK392.02907191
13PINK12.02672948
14TESK21.85882964
15EIF2AK11.84923564
16MST41.80967583
17MAPKAPK51.73630587
18NEK11.71500380
19IRAK31.69601419
20MAP4K21.67175045
21BMPR1B1.66625119
22BCR1.66130223
23IRAK41.64438281
24PIK3CG1.61817863
25MARK31.56709017
26TXK1.54311291
27VRK11.50668766
28ADRBK21.49640708
29KDR1.48975199
30TRIM281.48277314
31INSRR1.46445981
32OXSR11.45446123
33MYLK1.45340667
34MAP3K111.41169089
35CSNK1G11.38363992
36BMPR21.37765170
37WNK41.36908211
38MAP3K121.35033181
39CSNK1A1L1.34320160
40PIM21.33752193
41WNK31.33625462
42NUAK11.33096466
43LIMK11.30906379
44TNIK1.30431202
45GRK71.29666351
46SRPK11.28004403
47MAP3K141.27564952
48IRAK11.27125638
49PIK3CA1.23508156
50CAMK2B1.20195538
51TESK11.18288753
52CSNK1G21.17172584
53BLK1.15512181
54ZAK1.09101933
55IRAK21.08735856
56PLK31.07258273
57TLK11.05995424
58DAPK31.00519594
59TEC0.98164537
60GRK10.97209801
61CAMK2D0.95970742
62CDK190.95839488
63SCYL20.94139219
64PAK40.94090599
65CAMK2G0.93122555
66OBSCN0.90648638
67MAP2K70.88512175
68ARAF0.85432178
69CDK30.84080556
70SIK30.83159104
71NEK90.82810844
72WEE10.78502601
73IKBKE0.78303660
74MUSK0.78029160
75NEK60.77400752
76MAP3K50.77265326
77PRKCE0.75464978
78YES10.74486904
79ZAP700.72861552
80NLK0.72351291
81TBK10.72195064
82PASK0.71466771
83ABL20.71209775
84PLK10.70505971
85PAK10.70466752
86ADRBK10.69452184
87ILK0.69313341
88AURKA0.69010919
89DYRK20.67200204
90PRKG20.66415594
91LYN0.65814154
92EPHB20.65212660
93RIPK40.64252697
94TSSK60.63467955
95DAPK10.63368240
96RPS6KA50.63182858
97PLK20.62624807
98EIF2AK20.62256417
99CAMK2A0.62152108
100BRAF0.60370685
101FRK0.60220753
102CAMKK20.60170606
103NEK20.58324351
104GRK50.58143808
105EPHA30.57907012
106ACVR1B0.57309506
107PNCK0.55371875
108PRKCG0.54864919
109EPHA40.54532875
110CCNB10.54311957
111CSNK1G30.51842299
112TYK20.51054513
113PRKCQ0.50861090
114IKBKB0.50048807
115PLK40.46586575
116SYK0.46489529
117MAP2K20.46368735
118AKT30.46157790
119PRKACA0.45815640
120CSNK2A20.43123085
121PRKCD0.42330766
122CDK80.41010147
123CSNK2A10.40957691
124PKN10.40651340
125PRKCI0.39791000
126EPHB10.39508634
127CSNK1A10.39466189
128ITK0.39359183
129CSK0.38817398
130PRKCA0.38683722
131FGR0.38514620
132AURKB0.38287715
133EPHA20.38042075
134DAPK20.37558518
135MAP2K60.36497148
136MAPKAPK30.35514512
137MAP3K90.34527382
138CDC70.33268291
139STK40.30191337
140CLK10.28548849
141MAP3K10.28147805
142CDK140.28033891
143TTK0.26729876
144TAOK20.26522730
145STK100.26382748
146ATR0.24974569
147TGFBR10.24954237
148BRSK10.24688581
149MAP2K40.24529977

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.77054952
2Parkinsons disease_Homo sapiens_hsa050123.80959505
3Protein export_Homo sapiens_hsa030603.79543663
4Proteasome_Homo sapiens_hsa030503.28465102
5Alzheimers disease_Homo sapiens_hsa050102.89186070
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.77501301
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.68924826
8Huntingtons disease_Homo sapiens_hsa050162.59422843
9Steroid biosynthesis_Homo sapiens_hsa001002.37687908
10Fatty acid elongation_Homo sapiens_hsa000622.34078850
11Sulfur metabolism_Homo sapiens_hsa009202.15647971
12Ribosome_Homo sapiens_hsa030102.02130637
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.01823627
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.93426101
15Maturity onset diabetes of the young_Homo sapiens_hsa049501.88445684
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.79587137
17Primary bile acid biosynthesis_Homo sapiens_hsa001201.70907158
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.65997989
19Collecting duct acid secretion_Homo sapiens_hsa049661.51878330
20Folate biosynthesis_Homo sapiens_hsa007901.51742442
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.50626357
22Peroxisome_Homo sapiens_hsa041461.49083026
23RNA polymerase_Homo sapiens_hsa030201.47831784
24Graft-versus-host disease_Homo sapiens_hsa053321.47766701
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.46379484
26Homologous recombination_Homo sapiens_hsa034401.45934898
27SNARE interactions in vesicular transport_Homo sapiens_hsa041301.43790564
28Mismatch repair_Homo sapiens_hsa034301.41880044
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.41210479
30DNA replication_Homo sapiens_hsa030301.41115077
31Histidine metabolism_Homo sapiens_hsa003401.36368957
32Phenylalanine metabolism_Homo sapiens_hsa003601.34328459
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.33377095
34Vibrio cholerae infection_Homo sapiens_hsa051101.31874673
35Tyrosine metabolism_Homo sapiens_hsa003501.25990845
36Pyruvate metabolism_Homo sapiens_hsa006201.25255150
37Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.22966662
38Chemical carcinogenesis_Homo sapiens_hsa052041.22583728
39Butanoate metabolism_Homo sapiens_hsa006501.21409643
40Base excision repair_Homo sapiens_hsa034101.20998503
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.18769581
42Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.16752176
43Cardiac muscle contraction_Homo sapiens_hsa042601.16485732
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.14073160
45Rheumatoid arthritis_Homo sapiens_hsa053231.12223657
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.08634354
47Propanoate metabolism_Homo sapiens_hsa006401.04524074
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.04205879
49Tryptophan metabolism_Homo sapiens_hsa003801.03524317
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.99871667
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.99426899
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.98098049
53RNA transport_Homo sapiens_hsa030130.97614894
54Spliceosome_Homo sapiens_hsa030400.97363030
55RNA degradation_Homo sapiens_hsa030180.97015482
56Metabolic pathways_Homo sapiens_hsa011000.96217587
57Sphingolipid metabolism_Homo sapiens_hsa006000.94344259
58Pyrimidine metabolism_Homo sapiens_hsa002400.93942339
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91773988
60Glutathione metabolism_Homo sapiens_hsa004800.91190415
61Fanconi anemia pathway_Homo sapiens_hsa034600.89507714
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78451106
63Drug metabolism - other enzymes_Homo sapiens_hsa009830.76098299
64Caffeine metabolism_Homo sapiens_hsa002320.75980323
65Arginine and proline metabolism_Homo sapiens_hsa003300.75754844
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.75459693
67Retinol metabolism_Homo sapiens_hsa008300.74474496
68Systemic lupus erythematosus_Homo sapiens_hsa053220.73573004
69Legionellosis_Homo sapiens_hsa051340.72787524
70Regulation of autophagy_Homo sapiens_hsa041400.72393635
71Complement and coagulation cascades_Homo sapiens_hsa046100.71819135
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71089134
73One carbon pool by folate_Homo sapiens_hsa006700.70941772
74Antigen processing and presentation_Homo sapiens_hsa046120.69920371
75Phagosome_Homo sapiens_hsa041450.66677217
76Allograft rejection_Homo sapiens_hsa053300.64901303
77Epstein-Barr virus infection_Homo sapiens_hsa051690.64797543
78Fatty acid degradation_Homo sapiens_hsa000710.64384145
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63507503
80Type I diabetes mellitus_Homo sapiens_hsa049400.62606155
81Vitamin B6 metabolism_Homo sapiens_hsa007500.58858419
822-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.58355864
83Other glycan degradation_Homo sapiens_hsa005110.57346440
84Purine metabolism_Homo sapiens_hsa002300.56712245
85Nitrogen metabolism_Homo sapiens_hsa009100.55595910
86Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55285461
87Fatty acid metabolism_Homo sapiens_hsa012120.54325782
88Ether lipid metabolism_Homo sapiens_hsa005650.54103651
89Staphylococcus aureus infection_Homo sapiens_hsa051500.53090250
90Arachidonic acid metabolism_Homo sapiens_hsa005900.51902554
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.51344201
92p53 signaling pathway_Homo sapiens_hsa041150.49374646
93Basal transcription factors_Homo sapiens_hsa030220.49092080
94Synaptic vesicle cycle_Homo sapiens_hsa047210.48507223
95ABC transporters_Homo sapiens_hsa020100.47969580
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47671599
97Sulfur relay system_Homo sapiens_hsa041220.47104806
98African trypanosomiasis_Homo sapiens_hsa051430.46811850
99Fructose and mannose metabolism_Homo sapiens_hsa000510.46197389
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46088351
101Linoleic acid metabolism_Homo sapiens_hsa005910.45986594
102beta-Alanine metabolism_Homo sapiens_hsa004100.44951982
103Autoimmune thyroid disease_Homo sapiens_hsa053200.44420218
104Carbon metabolism_Homo sapiens_hsa012000.44326199
105Fat digestion and absorption_Homo sapiens_hsa049750.43928596
106Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.43455681
107Phototransduction_Homo sapiens_hsa047440.43428095
108N-Glycan biosynthesis_Homo sapiens_hsa005100.41915585
109Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40327556
110Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.39889173
111Biosynthesis of amino acids_Homo sapiens_hsa012300.38519209
112Viral myocarditis_Homo sapiens_hsa054160.37921136
113Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.37682658
114Malaria_Homo sapiens_hsa051440.37129896
115Hematopoietic cell lineage_Homo sapiens_hsa046400.35673693
116Non-homologous end-joining_Homo sapiens_hsa034500.35318674
117Mineral absorption_Homo sapiens_hsa049780.35259383
118Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.35120405
119Galactose metabolism_Homo sapiens_hsa000520.32866889
120Nucleotide excision repair_Homo sapiens_hsa034200.31128364
121Vitamin digestion and absorption_Homo sapiens_hsa049770.30714529
122Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.27770849
123PPAR signaling pathway_Homo sapiens_hsa033200.27017063
124Starch and sucrose metabolism_Homo sapiens_hsa005000.26974569
125Primary immunodeficiency_Homo sapiens_hsa053400.26781109
126Selenocompound metabolism_Homo sapiens_hsa004500.26625385
127alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26085092
128Asthma_Homo sapiens_hsa053100.25209496
129Arginine biosynthesis_Homo sapiens_hsa002200.25128489
130Shigellosis_Homo sapiens_hsa051310.24763370
131Intestinal immune network for IgA production_Homo sapiens_hsa046720.24324274
132Lysosome_Homo sapiens_hsa041420.23648246
133Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.22931672

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