SPTLC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)4.59565955
2surfactant homeostasis (GO:0043129)4.01958397
3cell adhesion mediated by integrin (GO:0033627)3.85999908
4response to peptidoglycan (GO:0032494)3.78366029
5positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.71901726
6negative regulation of erythrocyte differentiation (GO:0045647)3.59999375
7regulation of gamma-delta T cell activation (GO:0046643)3.59023108
8regulation of B cell receptor signaling pathway (GO:0050855)3.54782143
9B cell receptor signaling pathway (GO:0050853)3.50575439
10regulation of gamma-delta T cell differentiation (GO:0045586)3.47447736
11wound healing, spreading of epidermal cells (GO:0035313)3.42386720
12hepatocyte apoptotic process (GO:0097284)3.39915503
13definitive hemopoiesis (GO:0060216)3.35639517
14detection of molecule of bacterial origin (GO:0032490)3.33333458
15response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.32105912
16response to host (GO:0075136)3.32105912
17response to host defenses (GO:0052200)3.32105912
18response to host immune response (GO:0052572)3.31889130
19response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.31889130
20iron ion import (GO:0097286)3.29201288
21antigen processing and presentation via MHC class Ib (GO:0002475)3.28420439
22Arp2/3 complex-mediated actin nucleation (GO:0034314)3.28292824
23negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.28189551
24negative regulation of cell killing (GO:0031342)3.28189551
25basement membrane organization (GO:0071711)3.27998703
26cellular extravasation (GO:0045123)3.26437360
27detection of external biotic stimulus (GO:0098581)3.23861091
28modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.14059979
29positive regulation by organism of defense response of other organism involved in symbiotic interact3.14059979
30modulation by symbiont of host immune response (GO:0052553)3.14059979
31positive regulation by symbiont of host defense response (GO:0052509)3.14059979
32modulation by symbiont of host defense response (GO:0052031)3.14059979
33modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.14059979
34regulation of interferon-beta biosynthetic process (GO:0045357)3.12899734
35regulation of macrophage cytokine production (GO:0010935)3.08861872
36positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.06963345
37microglial cell activation (GO:0001774)3.06171273
38establishment of endothelial barrier (GO:0061028)3.04371736
39regulation of leukocyte degranulation (GO:0043300)3.02499450
40virion attachment to host cell (GO:0019062)3.02478598
41adhesion of symbiont to host cell (GO:0044650)3.02478598
42mesodermal cell differentiation (GO:0048333)3.01749889
43antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.00220812
44positive regulation of B cell differentiation (GO:0045579)2.98170964
45macrophage activation (GO:0042116)2.95104004
46histone H3-K36 demethylation (GO:0070544)2.94548556
47germ cell migration (GO:0008354)2.93995482
48apoptotic cell clearance (GO:0043277)2.92252211
49response to laminar fluid shear stress (GO:0034616)2.90777642
50regulation of myeloid leukocyte mediated immunity (GO:0002886)2.89097177
51wound healing, spreading of cells (GO:0044319)2.88740006
52negative regulation of interleukin-12 production (GO:0032695)2.86153477
53adhesion of symbiont to host (GO:0044406)2.85806244
54hemidesmosome assembly (GO:0031581)2.83276357
55morphogenesis of an endothelium (GO:0003159)2.79958132
56endothelial tube morphogenesis (GO:0061154)2.79958132
57detection of biotic stimulus (GO:0009595)2.79707647
58antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.76635010
59antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.76635010
60low-density lipoprotein particle clearance (GO:0034383)2.75683487
61myeloid cell activation involved in immune response (GO:0002275)2.73418979
62chemical homeostasis within a tissue (GO:0048875)2.72815865
63regulation of dendritic cell antigen processing and presentation (GO:0002604)2.69863446
64protein localization to endosome (GO:0036010)2.69615511
65neutrophil activation involved in immune response (GO:0002283)2.67449423
66endothelial cell morphogenesis (GO:0001886)2.66777939
67retina vasculature morphogenesis in camera-type eye (GO:0061299)2.65559633
68positive thymic T cell selection (GO:0045059)2.65162349
69phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.65136658
70macrophage activation involved in immune response (GO:0002281)2.64371557
71viral entry into host cell (GO:0046718)2.63164099
72regulation of mast cell degranulation (GO:0043304)2.62400082
73response to type I interferon (GO:0034340)2.61990089
74cellular response to type I interferon (GO:0071357)2.61092403
75type I interferon signaling pathway (GO:0060337)2.61092403
76regulation of regulated secretory pathway (GO:1903305)2.60938493
77positive regulation of SMAD protein import into nucleus (GO:0060391)2.60030063
78actin nucleation (GO:0045010)2.59707454
79positive regulation of interferon-alpha production (GO:0032727)2.58742878
80embryonic process involved in female pregnancy (GO:0060136)2.58547055
81renal filtration (GO:0097205)2.58123181
82regulation of B cell differentiation (GO:0045577)2.57991766
83hypotonic response (GO:0006971)2.57922631
84regulation of tolerance induction (GO:0002643)2.56654224
85megakaryocyte development (GO:0035855)2.54788593
86response to muramyl dipeptide (GO:0032495)2.54630731
87pinocytosis (GO:0006907)2.53842629
88positive regulation of Cdc42 GTPase activity (GO:0043089)2.52223173
89cellular response to growth hormone stimulus (GO:0071378)2.51025315
90endodermal cell differentiation (GO:0035987)2.50975972
91regulation of endothelial cell differentiation (GO:0045601)2.50843792
92positive regulation of cellular amide metabolic process (GO:0034250)2.50650192
93regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.50008177
94production of molecular mediator involved in inflammatory response (GO:0002532)2.48699032
95regulation of mast cell activation involved in immune response (GO:0033006)2.47462665
96respiratory burst (GO:0045730)2.46912552
97peptide catabolic process (GO:0043171)2.46750394
98I-kappaB phosphorylation (GO:0007252)2.46705863
99skin morphogenesis (GO:0043589)2.45802214
100positive regulation of regulated secretory pathway (GO:1903307)2.45760909
101endothelium development (GO:0003158)2.45730855
102negative regulation of lymphocyte mediated immunity (GO:0002707)2.45202313
103detection of other organism (GO:0098543)2.44629100
104regulation of interferon-alpha production (GO:0032647)2.44418316
105lipid translocation (GO:0034204)2.44306578
106phospholipid translocation (GO:0045332)2.44306578
107integrin-mediated signaling pathway (GO:0007229)2.43037866
108regulation of SMAD protein import into nucleus (GO:0060390)2.42912948
109antigen processing and presentation of endogenous antigen (GO:0019883)2.42461612
110dosage compensation (GO:0007549)2.40957909
111cellular response to interferon-alpha (GO:0035457)2.40048844
112negative regulation of T cell mediated immunity (GO:0002710)2.37386591
113hyaluronan catabolic process (GO:0030214)2.36857102
114positive regulation of tolerance induction (GO:0002645)2.36677250
115positive regulation of macrophage cytokine production (GO:0060907)2.36159819
116negative regulation of toll-like receptor signaling pathway (GO:0034122)2.35831582
117angiotensin maturation (GO:0002003)2.34695406
118vascular endothelial growth factor signaling pathway (GO:0038084)2.34521014
119B cell mediated immunity (GO:0019724)2.34519707
120positive regulation of antigen processing and presentation (GO:0002579)2.32966313
121regulation of T-helper 2 cell differentiation (GO:0045628)2.30519759
122membrane raft organization (GO:0031579)2.29101814
123interferon-gamma-mediated signaling pathway (GO:0060333)2.28637899
124positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.28561433
125regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.28541426
126detection of bacterium (GO:0016045)2.28368204
127leukocyte cell-cell adhesion (GO:0007159)2.28301750
128positive regulation of endothelial cell differentiation (GO:0045603)2.27971936
129growth hormone receptor signaling pathway (GO:0060396)2.27948722
130lipopolysaccharide-mediated signaling pathway (GO:0031663)2.27620061
131negative regulation of leukocyte mediated immunity (GO:0002704)2.27279097
132angiogenesis involved in wound healing (GO:0060055)2.27118755
133positive regulation of osteoblast proliferation (GO:0033690)2.26534587
134positive regulation of p38MAPK cascade (GO:1900745)2.25660482
135positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.23856607
136immunoglobulin mediated immune response (GO:0016064)2.22186399
137myeloid cell homeostasis (GO:0002262)2.20999755
138glomerular filtration (GO:0003094)2.19124659
139regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.19111971
140response to interferon-alpha (GO:0035455)2.16735019
141cortical actin cytoskeleton organization (GO:0030866)2.15399345
142regulation of podosome assembly (GO:0071801)2.15103604
143regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.14987603
144maintenance of gastrointestinal epithelium (GO:0030277)2.14868297
145glomerular visceral epithelial cell development (GO:0072015)2.13701111
146nuclear pore complex assembly (GO:0051292)2.13533946
147regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.13345430
148UDP-N-acetylglucosamine metabolic process (GO:0006047)2.13246721
149substrate adhesion-dependent cell spreading (GO:0034446)2.13129642
150negative regulation of interleukin-8 production (GO:0032717)2.13054969
151neutrophil activation (GO:0042119)2.12485240
152response to fluid shear stress (GO:0034405)2.12253678
153JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.11756226
154positive regulation of lamellipodium assembly (GO:0010592)2.10493172
155dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.10349755
156entry into host cell (GO:0030260)2.08210916
157movement in environment of other organism involved in symbiotic interaction (GO:0052192)2.08210916
158entry into cell of other organism involved in symbiotic interaction (GO:0051806)2.08210916
159entry into host (GO:0044409)2.08210916
160entry into other organism involved in symbiotic interaction (GO:0051828)2.08210916
161movement in host environment (GO:0052126)2.08210916
162endocardial cushion development (GO:0003197)2.07820251
163actin filament depolymerization (GO:0030042)2.07437337
164positive regulation of leukocyte degranulation (GO:0043302)2.07371988
165interferon-gamma secretion (GO:0072643)2.07125497
166positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.06811404
167regulation of antigen processing and presentation (GO:0002577)2.06526181
168leukocyte aggregation (GO:0070486)2.06014798

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.10832321
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.58368915
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.43529668
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.05623442
5* ESR1_20079471_ChIP-ChIP_T-47D_Human2.97076708
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.88352263
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.65386545
8E2F7_22180533_ChIP-Seq_HELA_Human2.63618863
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.63084608
10MYB_21317192_ChIP-Seq_ERMYB_Mouse2.58722290
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.51481737
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.50112931
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.43436444
14* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.36794958
15SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.34198328
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.33301781
17* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.32026680
18RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.28164858
19* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.19227123
20CLOCK_20551151_ChIP-Seq_293T_Human2.18326185
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.14268611
22SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.10844998
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.08931108
24GATA2_21666600_ChIP-Seq_HMVEC_Human2.06722819
25RARG_19884340_ChIP-ChIP_MEFs_Mouse2.00499416
26STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.91505644
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.88387392
28ESR1_21235772_ChIP-Seq_MCF-7_Human1.87706501
29* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.87035606
30FOXM1_23109430_ChIP-Seq_U2OS_Human1.78813836
31BRD4_27068464_Chip-Seq_AML-cells_Mouse1.78249094
32ZNF217_24962896_ChIP-Seq_MCF-7_Human1.77200818
33MYC_22102868_ChIP-Seq_BL_Human1.76714601
34NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.76533029
35* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.75167764
36* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.75167764
37AR_21909140_ChIP-Seq_LNCAP_Human1.74015059
38FOXO3_23340844_ChIP-Seq_DLD1_Human1.73414248
39KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.72306466
40STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.71162953
41ELK3_25401928_ChIP-Seq_HUVEC_Human1.69597469
42SALL4_18804426_ChIP-ChIP_XEN_Mouse1.68916492
43BP1_19119308_ChIP-ChIP_Hs578T_Human1.67862284
44* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.62667722
45SOX2_27498859_Chip-Seq_STOMACH_Mouse1.62127714
46* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.58739805
47CDX2_20551321_ChIP-Seq_CACO-2_Human1.58417598
48HIF1A_21447827_ChIP-Seq_MCF-7_Human1.58041057
49* SOX2_20726797_ChIP-Seq_SW620_Human1.57466117
50GATA1_19941826_ChIP-Seq_K562_Human1.55992020
51FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.52437067
52TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.50654053
53GATA6_25053715_ChIP-Seq_YYC3_Human1.50425344
54VDR_24787735_ChIP-Seq_THP-1_Human1.49610144
55TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.48080723
56KDM2B_26808549_Chip-Seq_SUP-B15_Human1.47552177
57* GATA4_25053715_ChIP-Seq_YYC3_Human1.44450491
58KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.42900726
59ESR2_21235772_ChIP-Seq_MCF-7_Human1.41672374
60GATA1_19941827_ChIP-Seq_MEL_Mouse1.41448170
61TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.41428307
62RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.40601082
63RUNX1_22412390_ChIP-Seq_EML_Mouse1.40098788
64E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.38678162
65GATA2_19941826_ChIP-Seq_K562_Human1.38493888
66SPI1_23547873_ChIP-Seq_NB4_Human1.37819172
67AHR_22903824_ChIP-Seq_MCF-7_Human1.36637367
68SALL1_21062744_ChIP-ChIP_HESCs_Human1.36341859
69ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.33695967
70SPI1_23127762_ChIP-Seq_K562_Human1.32512026
71VDR_24763502_ChIP-Seq_THP-1_Human1.32017717
72* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31886320
73STAT4_19710469_ChIP-ChIP_TH1__Mouse1.30959054
74FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.30116694
75SCL_19346495_ChIP-Seq_HPC-7_Human1.30112744
76ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29908437
77MYB_26560356_Chip-Seq_TH2_Human1.28476140
78JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27364444
79NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.26852226
80IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.26020865
81GATA1_22025678_ChIP-Seq_K562_Human1.24639874
82VDR_21846776_ChIP-Seq_THP-1_Human1.22612868
83MAF_26560356_Chip-Seq_TH1_Human1.22090806
84SOX9_24532713_ChIP-Seq_HFSC_Mouse1.21614605
85RUNX1_27514584_Chip-Seq_MCF-7_Human1.20961655
86KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.19278162
87RACK7_27058665_Chip-Seq_MCF-7_Human1.18692614
88NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.18380817
89* BRD4_25478319_ChIP-Seq_HGPS_Human1.18205713
90CJUN_26792858_Chip-Seq_BT549_Human1.17502712
91MYB_26560356_Chip-Seq_TH1_Human1.16269647
92P300_27058665_Chip-Seq_ZR-75-30cells_Human1.16228320
93FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15748860
94GATA3_27048872_Chip-Seq_THYMUS_Human1.15274824
95ATF3_27146783_Chip-Seq_COLON_Human1.15252784
96EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.15117236
97* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.15057179
98RUNX_20019798_ChIP-Seq_JUKART_Human1.13836030
99TCF7_22412390_ChIP-Seq_EML_Mouse1.13034896
100SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12907507
101UTX_26944678_Chip-Seq_JUKART_Human1.11707052
102ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.10080535
103STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09609891
104CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.09183294
105RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.08737330
106KDM2B_26808549_Chip-Seq_DND41_Human1.08481495
107* PU_27001747_Chip-Seq_BMDM_Mouse1.07674327
108CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.07175727
109ARNT_22903824_ChIP-Seq_MCF-7_Human1.07158023
110KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.06395119
111KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.06395119
112KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.06395119
113JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06381600
114STAT6_21828071_ChIP-Seq_BEAS2B_Human1.04718044
115KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.03999270
116GATA1_22383799_ChIP-Seq_G1ME_Mouse1.03785307
117ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00958489
118UBF1/2_26484160_Chip-Seq_HMECs_Human0.99719802
119* TCF3_18692474_ChIP-Seq_MEFs_Mouse0.99487787
120POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.99275038
121FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.96148500
122CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95822616
123NCOR1_26117541_ChIP-Seq_K562_Human0.95444266
124CTNNB1_20460455_ChIP-Seq_HCT116_Human0.95238398
125* CDX2_19796622_ChIP-Seq_MESCs_Mouse0.95031120
126GATA2_22383799_ChIP-Seq_G1ME_Mouse0.94816849
127TFEB_21752829_ChIP-Seq_HELA_Human0.94526568
128GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92116103
129FOXM1_26456572_ChIP-Seq_MCF-7_Human0.90895213
130GATA1_19941827_ChIP-Seq_MEL86_Mouse0.89443566
131DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.88461354
132* TP63_23658742_ChIP-Seq_EP156T_Human0.88239942

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003300_gastrointestinal_ulcer2.91427314
2MP0003705_abnormal_hypodermis_morpholog2.86532451
3MP0010234_abnormal_vibrissa_follicle2.80128851
4MP0010352_gastrointestinal_tract_polyps2.60463134
5MP0008438_abnormal_cutaneous_collagen2.56027742
6MP0001958_emphysema2.49510822
7MP0006054_spinal_hemorrhage2.41331048
8MP0002009_preneoplasia2.33158125
9MP0003566_abnormal_cell_adhesion2.31678837
10MP0005058_abnormal_lysosome_morphology2.24776795
11MP0004272_abnormal_basement_membrane2.18738575
12MP0009278_abnormal_bone_marrow2.15970517
13MP0003183_abnormal_peptide_metabolism2.03019040
14MP0003303_peritoneal_inflammation2.00955479
15MP0003724_increased_susceptibility_to1.99372056
16MP0004264_abnormal_extraembryonic_tissu1.93259688
17MP0008260_abnormal_autophagy1.87812251
18* MP0003191_abnormal_cellular_cholesterol1.84712618
19MP0003763_abnormal_thymus_physiology1.80773638
20MP0005023_abnormal_wound_healing1.76913660
21MP0004782_abnormal_surfactant_physiolog1.76562676
22MP0005409_darkened_coat_color1.72616138
23MP0008004_abnormal_stomach_pH1.71791734
24MP0003436_decreased_susceptibility_to1.70880892
25MP0003091_abnormal_cell_migration1.66584428
26MP0010368_abnormal_lymphatic_system1.64246417
27MP0008057_abnormal_DNA_replication1.62649990
28MP0003950_abnormal_plasma_membrane1.60430170
29MP0000569_abnormal_digit_pigmentation1.54807330
30MP0004947_skin_inflammation1.51641972
31MP0003448_altered_tumor_morphology1.49854869
32MP0009785_altered_susceptibility_to1.48426656
33MP0003656_abnormal_erythrocyte_physiolo1.45567618
34MP0002419_abnormal_innate_immunity1.44711046
35MP0009840_abnormal_foam_cell1.43919696
36MP0001545_abnormal_hematopoietic_system1.43894288
37MP0005397_hematopoietic_system_phenotyp1.43894288
38MP0001879_abnormal_lymphatic_vessel1.43852704
39MP0005083_abnormal_biliary_tract1.43459680
40MP0002877_abnormal_melanocyte_morpholog1.43284656
41MP0003866_abnormal_defecation1.42561018
42MP0010307_abnormal_tumor_latency1.41591579
43MP0010155_abnormal_intestine_physiology1.40640255
44MP0004883_abnormal_blood_vessel1.40619697
45MP0003453_abnormal_keratinocyte_physiol1.39715545
46MP0001873_stomach_inflammation1.38218445
47MP0002138_abnormal_hepatobiliary_system1.34838788
48MP0001835_abnormal_antigen_presentation1.32159794
49MP0002398_abnormal_bone_marrow1.30630597
50MP0001533_abnormal_skeleton_physiology1.30126986
51MP0005464_abnormal_platelet_physiology1.29794339
52MP0005025_abnormal_response_to1.28407195
53MP0005275_abnormal_skin_tensile1.28157073
54MP0005076_abnormal_cell_differentiation1.26988195
55MP0000465_gastrointestinal_hemorrhage1.25609196
56MP0010678_abnormal_skin_adnexa1.23046580
57MP0005501_abnormal_skin_physiology1.22694075
58MP0005167_abnormal_blood-brain_barrier1.19557755
59MP0002452_abnormal_antigen_presenting1.17972116
60MP0000716_abnormal_immune_system1.15707259
61MP0005387_immune_system_phenotype1.12347585
62MP0001790_abnormal_immune_system1.12347585
63MP0005408_hypopigmentation1.10313036
64MP0005310_abnormal_salivary_gland1.09933747
65MP0004808_abnormal_hematopoietic_stem1.09051699
66MP0000490_abnormal_crypts_of1.08705349
67MP0000343_altered_response_to1.08456964
68MP0000858_altered_metastatic_potential1.07890005
69MP0002166_altered_tumor_susceptibility1.05689677
70MP0005257_abnormal_intraocular_pressure1.03099564
71MP0002148_abnormal_hypersensitivity_rea1.02572747
72MP0003045_fibrosis1.02340819
73MP0005164_abnormal_response_to1.02089071
74MP0000015_abnormal_ear_pigmentation1.01256135
75MP0006082_CNS_inflammation1.00095714
76MP0002722_abnormal_immune_system0.99567922
77MP0002429_abnormal_blood_cell0.99327810
78MP0002295_abnormal_pulmonary_circulatio0.97853396
79MP0004381_abnormal_hair_follicle0.97716316
80MP0001819_abnormal_immune_cell0.97703089
81MP0005000_abnormal_immune_tolerance0.97273272
82MP0000689_abnormal_spleen_morphology0.96614643
83MP0003690_abnormal_glial_cell0.96581872
84MP0002420_abnormal_adaptive_immunity0.95756938
85MP0002396_abnormal_hematopoietic_system0.94855377
86MP0002998_abnormal_bone_remodeling0.94412781
87MP0003828_pulmonary_edema0.94337548
88MP0003172_abnormal_lysosome_physiology0.94117109
89MP0002796_impaired_skin_barrier0.93110192
90MP0001851_eye_inflammation0.92789320
91MP0001845_abnormal_inflammatory_respons0.92425713
92MP0002405_respiratory_system_inflammati0.92217692
93MP0000685_abnormal_immune_system0.91965318
94MP0005621_abnormal_cell_physiology0.91787300
95MP0002723_abnormal_immune_serum0.91481404
96MP0001216_abnormal_epidermal_layer0.91332007
97MP0005671_abnormal_response_to0.90203491
98MP0002136_abnormal_kidney_physiology0.89496633
99MP0000377_abnormal_hair_follicle0.89383883
100MP0003279_aneurysm0.88402385
101MP0000477_abnormal_intestine_morphology0.88159803
102MP0003941_abnormal_skin_development0.87647807
103MP0000733_abnormal_muscle_development0.87364976
104MP0000767_abnormal_smooth_muscle0.85705880
105MP0000372_irregular_coat_pigmentation0.85507523
106MP0002006_tumorigenesis0.85102540
107MP0001800_abnormal_humoral_immune0.83978369
108MP0000371_diluted_coat_color0.83777752
109MP0002086_abnormal_extraembryonic_tissu0.83409083
110MP0000249_abnormal_blood_vessel0.83305973
111MP0005451_abnormal_body_composition0.82264330
112MP0004185_abnormal_adipocyte_glucose0.81961656
113MP0000703_abnormal_thymus_morphology0.81887959
114MP0000427_abnormal_hair_cycle0.81175486
115MP0001915_intracranial_hemorrhage0.80720504
116MP0002060_abnormal_skin_morphology0.79858797
117MP0000383_abnormal_hair_follicle0.79697611
118MP0002132_abnormal_respiratory_system0.78159611
119MP0002168_other_aberrant_phenotype0.76991224
120MP0009333_abnormal_splenocyte_physiolog0.76976911
121MP0005165_increased_susceptibility_to0.76236280
122MP0003943_abnormal_hepatobiliary_system0.75235423
123MP0009643_abnormal_urine_homeostasis0.74717271
124MP0003795_abnormal_bone_structure0.74304847
125MP0005388_respiratory_system_phenotype0.72860786
126MP0002133_abnormal_respiratory_system0.72860786
127MP0002925_abnormal_cardiovascular_devel0.72824665
128MP0000627_abnormal_mammary_gland0.72515739
129MP0000604_amyloidosis0.72159186
130MP0001614_abnormal_blood_vessel0.71915817
131MP0002098_abnormal_vibrissa_morphology0.71722061

Predicted human phenotypes

RankGene SetZ-score
1Interstitial pulmonary disease (HP:0006530)5.08449452
2Hematochezia (HP:0002573)3.79640921
3Recurrent abscess formation (HP:0002722)3.38658480
4Premature rupture of membranes (HP:0001788)3.35522748
5Osteolytic defects of the phalanges of the hand (HP:0009771)3.29003204
6Osteolytic defects of the hand bones (HP:0009699)3.29003204
7Abnormality of macrophages (HP:0004311)3.23698176
8Eczematoid dermatitis (HP:0000976)3.17138081
9Cerebral aneurysm (HP:0004944)2.92449859
10Vacuolated lymphocytes (HP:0001922)2.86540009
11Cervical subluxation (HP:0003308)2.83225181
12Pustule (HP:0200039)2.82329949
13Chronic mucocutaneous candidiasis (HP:0002728)2.82200785
14Recurrent cutaneous fungal infections (HP:0011370)2.82200785
15Increased cerebral lipofuscin (HP:0011813)2.74377236
16Recurrent bacterial skin infections (HP:0005406)2.72572515
17Spontaneous hematomas (HP:0007420)2.69624337
18Recurrent fungal infections (HP:0002841)2.67641402
19Recurrent viral infections (HP:0004429)2.66654369
20Esophageal varix (HP:0002040)2.65500426
21Atrophic scars (HP:0001075)2.63501022
22Ulnar bowing (HP:0003031)2.59906809
23Viral hepatitis (HP:0006562)2.53704132
24Orchitis (HP:0100796)2.51789237
25Aortic dissection (HP:0002647)2.47666141
26Abnormal delayed hypersensitivity skin test (HP:0002963)2.46750311
27Papillary thyroid carcinoma (HP:0002895)2.46640773
28Increased neuronal autofluorescent lipopigment (HP:0002074)2.46014367
29Autoimmune thrombocytopenia (HP:0001973)2.43267973
30Aortic aneurysm (HP:0004942)2.41874312
31Colitis (HP:0002583)2.41602765
32Abnormality of the vasculature of the conjunctiva (HP:0008054)2.37983081
33Prolonged bleeding time (HP:0003010)2.37821995
34Acute myeloid leukemia (HP:0004808)2.36299788
35T lymphocytopenia (HP:0005403)2.33593530
36Arterial thrombosis (HP:0004420)2.31941165
37Dysostosis multiplex (HP:0000943)2.31741762
38Nonimmune hydrops fetalis (HP:0001790)2.31064645
39Inflammation of the large intestine (HP:0002037)2.29541225
40Subacute progressive viral hepatitis (HP:0006572)2.29008586
41Mucopolysacchariduria (HP:0008155)2.28652050
42Urinary glycosaminoglycan excretion (HP:0003541)2.28652050
43Ankyloglossia (HP:0010296)2.28171762
44Chest pain (HP:0100749)2.26101824
45Ileus (HP:0002595)2.26097658
46Urticaria (HP:0001025)2.25192979
47Gastrointestinal inflammation (HP:0004386)2.24829102
48Abnormality of nail color (HP:0100643)2.24681262
49Optic neuritis (HP:0100653)2.23414479
50Retrobulbar optic neuritis (HP:0100654)2.23414479
51Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.21719590
52Spondylolisthesis (HP:0003302)2.17965956
53Meningitis (HP:0001287)2.17870351
54Flat acetabular roof (HP:0003180)2.17616547
55Absent frontal sinuses (HP:0002688)2.17437943
56Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.17188447
57Thoracolumbar scoliosis (HP:0002944)2.17029654
58Rectal prolapse (HP:0002035)2.16973433
59Ankle contracture (HP:0006466)2.16863490
60Right ventricular cardiomyopathy (HP:0011663)2.16277005
61Deep philtrum (HP:0002002)2.15854653
62Abnormality of the fingertips (HP:0001211)2.15584430
63Abnormality of T cell number (HP:0011839)2.14391055
64Segmental peripheral demyelination/remyelination (HP:0003481)2.13217343
65Epistaxis (HP:0000421)2.11151380
66Peritonitis (HP:0002586)2.11053973
67Thick nail (HP:0001805)2.10029817
68Gastrointestinal infarctions (HP:0005244)2.08808145
69Shallow orbits (HP:0000586)2.08758527
70Mediastinal lymphadenopathy (HP:0100721)2.08516134
71Protrusio acetabuli (HP:0003179)2.06433403
72Petechiae (HP:0000967)2.05770182
73Abnormality of oral frenula (HP:0000190)2.05664321
74Metaphyseal cupping (HP:0003021)2.05097981
75* Osteomyelitis (HP:0002754)2.04615891
76Curly hair (HP:0002212)2.04596136
77Increased mean platelet volume (HP:0011877)2.04277926
78Abnormality of mucopolysaccharide metabolism (HP:0011020)2.03595749
79Abnormality of polysaccharide metabolism (HP:0011012)2.03595749
80Abnormality of glycosaminoglycan metabolism (HP:0004371)2.03595749
81Cheilitis (HP:0100825)2.02194409
82Abnormal platelet volume (HP:0011876)2.01879386
83Coarse hair (HP:0002208)1.98752201
84Thin bony cortex (HP:0002753)1.98546517
85Autoimmune hemolytic anemia (HP:0001890)1.97658324
86Severe short stature (HP:0003510)1.95896408
87Hyperactive renin-angiotensin system (HP:0000841)1.95852694
88Recurrent bronchitis (HP:0002837)1.93785531
89Cupped ribs (HP:0000887)1.92433600
90Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.92296596
91Arterial tortuosity (HP:0005116)1.91966059
92Amyloidosis (HP:0011034)1.91645720
93Radial bowing (HP:0002986)1.91240163
94Conjunctival telangiectasia (HP:0000524)1.89900314
95Abnormality of the distal phalanges of the toes (HP:0010182)1.89339371
96Periodontitis (HP:0000704)1.88823323
97Vasculitis (HP:0002633)1.88403383
98Gingivitis (HP:0000230)1.87736384
99Vascular tortuosity (HP:0004948)1.87578862
100Bowing of the arm (HP:0006488)1.86741953
101Bowed forearm bones (HP:0003956)1.86741953
102Chronic otitis media (HP:0000389)1.86696561
103Focal segmental glomerulosclerosis (HP:0000097)1.86531210
104Syringomyelia (HP:0003396)1.86479307
105Spinal cord lesions (HP:0100561)1.86479307
106Abnormality of chloride homeostasis (HP:0011422)1.84356049
107Abnormality of the lumbar spine (HP:0100712)1.83976329
108* Skin ulcer (HP:0200042)1.80798524
109Agammaglobulinemia (HP:0004432)1.80580837
110Micronodular cirrhosis (HP:0001413)1.80432815
111Abnormality of the peritoneum (HP:0002585)1.79388506
112Keratoconjunctivitis sicca (HP:0001097)1.79183852
113Loss of speech (HP:0002371)1.78932343
114Myositis (HP:0100614)1.78410286
115Persistence of primary teeth (HP:0006335)1.77501836
116Sparse lateral eyebrow (HP:0005338)1.77369922
117Abnormal glucose tolerance (HP:0001952)1.77087607
118Scanning speech (HP:0002168)1.76855411
119Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.76394670
120Increased IgE level (HP:0003212)1.76210276
121Elevated erythrocyte sedimentation rate (HP:0003565)1.76042690
122Aneurysm (HP:0002617)1.75955683
123Glucose intolerance (HP:0000833)1.75071866
124Thrombocytosis (HP:0001894)1.74848953
125Abnormal foot bone ossification (HP:0010675)1.73306940
126Chronic diarrhea (HP:0002028)1.71795286
127Pili torti (HP:0003777)1.71704461
128Visceral angiomatosis (HP:0100761)1.70703627
129Dilatation of the ascending aorta (HP:0005111)1.70118859
130Cellulitis (HP:0100658)1.69805876
131Recurrent gram-negative bacterial infections (HP:0005420)1.69073958
132Hemoptysis (HP:0002105)1.69039167
133Tubulointerstitial fibrosis (HP:0005576)1.68299446
134Hemangiomatosis (HP:0007461)1.67097857
135Blue sclerae (HP:0000592)1.66816050
136Hand muscle atrophy (HP:0009130)1.66683287
137Platyspondyly (HP:0000926)1.66338359
138Amaurosis fugax (HP:0100576)1.66082966
139Disinhibition (HP:0000734)1.64885784
140Encephalitis (HP:0002383)1.64561392
141Glomerulosclerosis (HP:0000096)1.63993360
142Abnormality of proline metabolism (HP:0010907)1.62990161
143Hydroxyprolinuria (HP:0003080)1.62990161
144Renal salt wasting (HP:0000127)1.62666642
145Increased CSF protein (HP:0002922)1.61778090
146Mitral valve prolapse (HP:0001634)1.61738867
147Pulmonary infiltrates (HP:0002113)1.61634537
148Axonal loss (HP:0003447)1.61482386
149Milia (HP:0001056)1.60184806
150Polycythemia (HP:0001901)1.59794620
151Bronchitis (HP:0012387)1.59511580
152Abnormality of the distal phalanx of the thumb (HP:0009617)1.58003791
153Obstructive lung disease (HP:0006536)1.57498355
154Chronic obstructive pulmonary disease (HP:0006510)1.57498355
155Recurrent skin infections (HP:0001581)1.57139129
156Bone pain (HP:0002653)1.56656196
157Abnormality of the acetabulum (HP:0003170)1.56409018
158Bilateral sensorineural hearing impairment (HP:0008619)1.55039440
159Gingival bleeding (HP:0000225)1.54701567
160Beaking of vertebral bodies (HP:0004568)1.52804346
161Wormian bones (HP:0002645)1.51295463
162Disproportionate tall stature (HP:0001519)1.50949304

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA23.94548821
2RIPK43.59507974
3PRPF4B2.94770876
4MST1R2.51351108
5EPHB12.50831210
6MST42.49124056
7STK102.41178841
8TGFBR22.21382258
9PAK42.20517021
10FRK2.17923347
11KDR2.11230731
12LRRK22.11179538
13LATS12.05803062
14ERN11.99141646
15FES1.95300492
16PTK61.88043797
17BMPR21.84261039
18BTK1.83126631
19MAP2K31.79197451
20SCYL21.76533048
21SMG11.75287639
22MET1.69897620
23RIPK11.69011079
24TYK21.61755019
25TBK11.57668138
26MAP3K31.55597929
27YES11.54181364
28PKN21.53755763
29MAP4K11.45225522
30TIE11.41570204
31TTN1.37752867
32ZAP701.35954119
33CDK121.35618868
34STK31.35280520
35EPHA31.26364529
36TRIB31.25994442
37SIK11.21052159
38DDR21.20693496
39PIM21.20300305
40MAP3K81.18834750
41GRK61.18573529
42SYK1.17726717
43BMX1.14167506
44CDK61.11439773
45CSK1.10609582
46NEK91.08981747
47PTK21.08362900
48MAP3K61.07575880
49PIK3CG1.07080968
50TRPM71.06800009
51NME21.06504788
52TESK11.05448736
53PRKG21.05260754
54JAK11.04740570
55BLK1.03781980
56KIT1.03487890
57MAP3K141.02071228
58MAP2K21.00741302
59MAP3K11.00558297
60TESK21.00342661
61RPS6KA41.00328012
62PIM10.95977124
63JAK30.94291221
64WNK10.91754954
65FGFR40.91335325
66RET0.90219725
67FGFR30.89801883
68TGFBR10.89146407
69MAP3K110.88059210
70NLK0.86587744
71LYN0.86073557
72BRD40.85474320
73STK390.81967500
74FLT30.81885228
75MARK20.81539989
76PDGFRA0.81259970
77EPHB20.80965909
78ICK0.80535873
79GSK3A0.79777640
80NEK60.78890368
81MAP3K20.78097419
82PDGFRB0.77812846
83MARK30.75659750
84KSR20.74558927
85RPS6KB20.74465347
86NUAK10.74414330
87PDK10.71849049
88TAOK30.70712630
89SGK30.67814468
90CSF1R0.67719401
91PDPK10.67645907
92CAMK1G0.66977187
93IKBKB0.65501409
94FER0.65383259
95MAP3K120.63649320
96MATK0.63478708
97IKBKE0.63282743
98ITK0.62155902
99PTK2B0.61240655
100EGFR0.61098023
101TNK20.60503292
102JAK20.60484764
103LIMK10.59753690
104IRAK10.59043182
105CLK10.58308765
106MAPKAPK30.57719869
107MAP3K100.56801096
108OXSR10.56481647
109EIF2AK10.56221358
110MELK0.56191730
111CAMK1D0.55273372
112PAK20.54699650
113PRKD20.54448321
114IRAK40.54322220
115CHUK0.54068120
116WNK40.54016823
117STK40.53682376
118ALK0.53061697
119TAOK10.52585884
120NEK20.52389574
121HCK0.52308046
122HIPK20.52216690
123FYN0.51949269
124EEF2K0.51665417
125STK240.48226357
126MAP2K10.47705887
127MAP3K50.47665223
128AKT30.46352411
129CDC42BPA0.45866260
130ABL10.45583881
131IRAK30.44854009
132LCK0.44773567
133TEC0.44424064
134STK380.44062932
135MAP3K130.43848391
136FGFR20.42865778
137MTOR0.42556968
138ERBB40.42226038
139PIK3CA0.42100989
140FGR0.41105214
141MAPKAPK20.38881849
142SGK20.38201964

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.06605704
2Leukocyte transendothelial migration_Homo sapiens_hsa046702.03603384
3Mineral absorption_Homo sapiens_hsa049781.89268741
4ECM-receptor interaction_Homo sapiens_hsa045121.87123581
5Lysosome_Homo sapiens_hsa041421.86283671
6Glycosaminoglycan degradation_Homo sapiens_hsa005311.83947651
7Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.83418042
8Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.82547484
9Shigellosis_Homo sapiens_hsa051311.82272314
10Pertussis_Homo sapiens_hsa051331.80681478
11Malaria_Homo sapiens_hsa051441.76584468
12Renin-angiotensin system_Homo sapiens_hsa046141.74452763
13Other glycan degradation_Homo sapiens_hsa005111.72365453
14Caffeine metabolism_Homo sapiens_hsa002321.68487237
15Small cell lung cancer_Homo sapiens_hsa052221.67602976
16Toxoplasmosis_Homo sapiens_hsa051451.64365906
17Non-small cell lung cancer_Homo sapiens_hsa052231.62683987
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.58878660
19Adherens junction_Homo sapiens_hsa045201.56889849
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.54605555
21Osteoclast differentiation_Homo sapiens_hsa043801.50666829
22Focal adhesion_Homo sapiens_hsa045101.42213593
23Salmonella infection_Homo sapiens_hsa051321.40914073
24Apoptosis_Homo sapiens_hsa042101.39747122
25Antigen processing and presentation_Homo sapiens_hsa046121.35492343
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.34919078
27Endometrial cancer_Homo sapiens_hsa052131.32972481
28AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.32592485
29Hematopoietic cell lineage_Homo sapiens_hsa046401.29882214
30Legionellosis_Homo sapiens_hsa051341.29501204
31TNF signaling pathway_Homo sapiens_hsa046681.28272990
32Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.26070940
33Hepatitis C_Homo sapiens_hsa051601.26021530
34Proteoglycans in cancer_Homo sapiens_hsa052051.25750344
35Chronic myeloid leukemia_Homo sapiens_hsa052201.23776092
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.21591901
37T cell receptor signaling pathway_Homo sapiens_hsa046601.21407697
38Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.18927951
39Phagosome_Homo sapiens_hsa041451.18755864
40Tuberculosis_Homo sapiens_hsa051521.16135039
41Pancreatic cancer_Homo sapiens_hsa052121.15324666
42Amoebiasis_Homo sapiens_hsa051461.14814352
43Protein digestion and absorption_Homo sapiens_hsa049741.14326517
44MicroRNAs in cancer_Homo sapiens_hsa052061.13568138
45Inositol phosphate metabolism_Homo sapiens_hsa005621.13031239
46Influenza A_Homo sapiens_hsa051641.11622432
47Measles_Homo sapiens_hsa051621.09004736
48Viral myocarditis_Homo sapiens_hsa054161.08933344
49Autoimmune thyroid disease_Homo sapiens_hsa053201.08050850
50Graft-versus-host disease_Homo sapiens_hsa053321.07550136
51Allograft rejection_Homo sapiens_hsa053301.07483589
52Vitamin digestion and absorption_Homo sapiens_hsa049771.06841570
53* Sphingolipid metabolism_Homo sapiens_hsa006001.06318034
54Bladder cancer_Homo sapiens_hsa052191.05787420
55Platelet activation_Homo sapiens_hsa046111.05423250
56B cell receptor signaling pathway_Homo sapiens_hsa046621.03478796
57RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.02651900
58Regulation of actin cytoskeleton_Homo sapiens_hsa048101.00943507
59Choline metabolism in cancer_Homo sapiens_hsa052310.99839112
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.98254114
61Staphylococcus aureus infection_Homo sapiens_hsa051500.97885837
62Asthma_Homo sapiens_hsa053100.96927490
63Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.96837047
64Tight junction_Homo sapiens_hsa045300.95603611
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.93880633
66Steroid biosynthesis_Homo sapiens_hsa001000.93434473
67Jak-STAT signaling pathway_Homo sapiens_hsa046300.91620702
68Intestinal immune network for IgA production_Homo sapiens_hsa046720.91323343
69ErbB signaling pathway_Homo sapiens_hsa040120.91257664
70Thyroid cancer_Homo sapiens_hsa052160.91203988
71Hepatitis B_Homo sapiens_hsa051610.90423540
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.89910620
73p53 signaling pathway_Homo sapiens_hsa041150.88485122
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88406525
75Viral carcinogenesis_Homo sapiens_hsa052030.84486136
76Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.83344380
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.82853732
78Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.81611281
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81398242
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80856913
81PI3K-Akt signaling pathway_Homo sapiens_hsa041510.79738457
82Acute myeloid leukemia_Homo sapiens_hsa052210.79612453
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.79233217
84Herpes simplex infection_Homo sapiens_hsa051680.78554850
85Glioma_Homo sapiens_hsa052140.78520478
86Estrogen signaling pathway_Homo sapiens_hsa049150.78402854
87Glutathione metabolism_Homo sapiens_hsa004800.77512483
88GnRH signaling pathway_Homo sapiens_hsa049120.77308319
89TGF-beta signaling pathway_Homo sapiens_hsa043500.76543687
90Endocytosis_Homo sapiens_hsa041440.76270224
91Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.73306262
92Renal cell carcinoma_Homo sapiens_hsa052110.73260679
93VEGF signaling pathway_Homo sapiens_hsa043700.70345477
94* Sphingolipid signaling pathway_Homo sapiens_hsa040710.69535748
95Rheumatoid arthritis_Homo sapiens_hsa053230.69035444
96Prostate cancer_Homo sapiens_hsa052150.68997438
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68699861
98Insulin resistance_Homo sapiens_hsa049310.68026553
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67454350
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66527397
101FoxO signaling pathway_Homo sapiens_hsa040680.64710873
102Pathways in cancer_Homo sapiens_hsa052000.62963199
103Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.62061234
104Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.61980362
105Type I diabetes mellitus_Homo sapiens_hsa049400.61837867
106Hippo signaling pathway_Homo sapiens_hsa043900.61199972
107Chemokine signaling pathway_Homo sapiens_hsa040620.58261769
108Rap1 signaling pathway_Homo sapiens_hsa040150.57606950
109Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.57356164
110Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.56658176
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54805324
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.54315632
113Primary immunodeficiency_Homo sapiens_hsa053400.54181610
114Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53632957
115Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52974706
116HTLV-I infection_Homo sapiens_hsa051660.52742000
117Colorectal cancer_Homo sapiens_hsa052100.52172125
118Fat digestion and absorption_Homo sapiens_hsa049750.51343093
119Prolactin signaling pathway_Homo sapiens_hsa049170.49847369
120Neurotrophin signaling pathway_Homo sapiens_hsa047220.47331732
121Notch signaling pathway_Homo sapiens_hsa043300.46347970
122HIF-1 signaling pathway_Homo sapiens_hsa040660.46239358
123Dorso-ventral axis formation_Homo sapiens_hsa043200.45902214
124mTOR signaling pathway_Homo sapiens_hsa041500.45109622
125African trypanosomiasis_Homo sapiens_hsa051430.43775976
126N-Glycan biosynthesis_Homo sapiens_hsa005100.43126432

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