SPTLC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the class-II pyridoxal-phosphate-dependent aminotransferase family. The encoded protein is the long chain base subunit 1 of serine palmitoyltransferase. Serine palmitoyltransferase converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate and is the key enzyme in sphingolipid biosynthesis. Mutations in this gene were identified in patients with hereditary sensory neuropathy type 1. Alternatively spliced variants encoding different isoforms have been identified. Pseudogenes of this gene have been defined on chromosomes 1, 6, 10, and 13. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)7.62787842
2central nervous system myelination (GO:0022010)7.62787842
3fatty acid elongation (GO:0030497)7.31317912
4Golgi transport vesicle coating (GO:0048200)6.17353435
5COPI coating of Golgi vesicle (GO:0048205)6.17353435
6nuclear pore complex assembly (GO:0051292)5.67554805
7nuclear pore organization (GO:0006999)5.09082370
8ensheathment of neurons (GO:0007272)4.90527782
9axon ensheathment (GO:0008366)4.90527782
10hemidesmosome assembly (GO:0031581)4.90428218
11long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.88790848
12myelination (GO:0042552)4.82741604
13response to lipoprotein particle (GO:0055094)4.76465961
14ribosome assembly (GO:0042255)4.68374474
15COPII vesicle coating (GO:0048208)4.65753993
16cholesterol biosynthetic process (GO:0006695)4.57050617
17fatty-acyl-CoA biosynthetic process (GO:0046949)4.50475137
18pore complex assembly (GO:0046931)4.32390676
19cell adhesion mediated by integrin (GO:0033627)4.25704973
20long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.22102868
21amyloid precursor protein catabolic process (GO:0042987)4.12052851
22fatty-acyl-CoA metabolic process (GO:0035337)4.11281446
23amyloid precursor protein metabolic process (GO:0042982)4.06993570
24sterol biosynthetic process (GO:0016126)4.02545484
25protein localization to endosome (GO:0036010)3.93017003
26virion attachment to host cell (GO:0019062)3.85301949
27adhesion of symbiont to host cell (GO:0044650)3.85301949
28myelin maintenance (GO:0043217)3.79996231
29acyl-CoA biosynthetic process (GO:0071616)3.77879528
30thioester biosynthetic process (GO:0035384)3.77879528
31establishment of integrated proviral latency (GO:0075713)3.77361841
32very long-chain fatty acid metabolic process (GO:0000038)3.75892131
33nucleotide transmembrane transport (GO:1901679)3.75023323
34regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.66855636
35regulation of lipoprotein metabolic process (GO:0050746)3.66555859
36erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.63757986
37L-phenylalanine catabolic process (GO:0006559)3.63757986
38creatine metabolic process (GO:0006600)3.58558674
39vesicle coating (GO:0006901)3.51928570
40positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.51281283
41positive regulation of oligodendrocyte differentiation (GO:0048714)3.50527211
42L-phenylalanine metabolic process (GO:0006558)3.44958113
43erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.44958113
44leukocyte migration involved in inflammatory response (GO:0002523)3.44618456
45regulation of sister chromatid cohesion (GO:0007063)3.32547710
46bundle of His cell to Purkinje myocyte communication (GO:0086069)3.31899880
47metaphase plate congression (GO:0051310)3.29704488
48double-strand break repair via nonhomologous end joining (GO:0006303)3.29105684
49non-recombinational repair (GO:0000726)3.29105684
50regulation of centriole replication (GO:0046599)3.29063621
51mitotic metaphase plate congression (GO:0007080)3.25645754
52skin morphogenesis (GO:0043589)3.23839506
53UDP-N-acetylglucosamine metabolic process (GO:0006047)3.23442789
54L-serine transport (GO:0015825)3.19377113
55retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.15052348
56establishment of chromosome localization (GO:0051303)3.14749472
57long-chain fatty acid biosynthetic process (GO:0042759)3.13724345
58pyrimidine-containing compound transmembrane transport (GO:0072531)3.13344938
59adhesion of symbiont to host (GO:0044406)3.12242527
60NADPH regeneration (GO:0006740)3.09879153
61pentose-phosphate shunt (GO:0006098)3.07831828
62tRNA aminoacylation for protein translation (GO:0006418)3.05556993
63import into cell (GO:0098657)3.03969910
64magnesium ion transport (GO:0015693)2.94722642
65mitotic nuclear envelope disassembly (GO:0007077)2.93827650
66positive regulation of cellular amine metabolic process (GO:0033240)2.93546972
67membrane protein ectodomain proteolysis (GO:0006509)2.92906987
68mitotic sister chromatid cohesion (GO:0007064)2.92084716
69amino acid activation (GO:0043038)2.91293562
70tRNA aminoacylation (GO:0043039)2.91293562
71proline biosynthetic process (GO:0006561)2.89412423
72glutathione derivative biosynthetic process (GO:1901687)2.89219592
73glutathione derivative metabolic process (GO:1901685)2.89219592
74maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.86323252
75nucleotide-sugar biosynthetic process (GO:0009226)2.85648896
76establishment of viral latency (GO:0019043)2.84564867
77regulation of translational fidelity (GO:0006450)2.84015964
78nuclear envelope disassembly (GO:0051081)2.83820675
79membrane disassembly (GO:0030397)2.83820675
80triglyceride biosynthetic process (GO:0019432)2.81309272
81interleukin-6-mediated signaling pathway (GO:0070102)2.81183875
82serine transport (GO:0032329)2.80778480
83isoprenoid biosynthetic process (GO:0008299)2.80657883
84L-serine metabolic process (GO:0006563)2.79791585
85regulation of mitotic spindle organization (GO:0060236)2.79510886
86negative regulation of fibroblast apoptotic process (GO:2000270)2.79466269
87acyl-CoA metabolic process (GO:0006637)2.78892319
88thioester metabolic process (GO:0035383)2.78892319
89acylglycerol biosynthetic process (GO:0046463)2.77636385
90neutral lipid biosynthetic process (GO:0046460)2.77636385
91negative regulation of acute inflammatory response (GO:0002674)2.77151689
92positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.76771515
93positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.76771515
94positive regulation of mitotic sister chromatid separation (GO:1901970)2.76771515
95mesodermal cell differentiation (GO:0048333)2.75098634
96glycerophospholipid catabolic process (GO:0046475)2.73713003
97mitochondrial DNA replication (GO:0006264)2.73337573
98positive regulation of chromosome segregation (GO:0051984)2.73149009
99protein localization to chromosome, centromeric region (GO:0071459)2.73055313
100response to phenylpropanoid (GO:0080184)2.72896153
101iron ion import (GO:0097286)2.72550486
102asymmetric protein localization (GO:0008105)2.70576445
103cholesterol metabolic process (GO:0008203)2.68668672
104oligodendrocyte differentiation (GO:0048709)2.67463900
105mitotic chromosome condensation (GO:0007076)2.67129324
106phosphatidylserine metabolic process (GO:0006658)2.66457933
107ER to Golgi vesicle-mediated transport (GO:0006888)2.65316361
108mitotic sister chromatid segregation (GO:0000070)2.64618817
109serine family amino acid biosynthetic process (GO:0009070)2.64080085
110formation of translation preinitiation complex (GO:0001731)2.63570245
111protein complex localization (GO:0031503)2.63191572
112ER overload response (GO:0006983)2.62950616
113mitotic cytokinesis (GO:0000281)2.62890203
114heme transport (GO:0015886)2.60588603
115response to X-ray (GO:0010165)2.60366855
116cellular protein complex localization (GO:0034629)2.60043555
117regulation of transforming growth factor beta2 production (GO:0032909)2.59751687
118myeloid cell homeostasis (GO:0002262)2.59521004
119ethanol metabolic process (GO:0006067)2.59467594
120cellular copper ion homeostasis (GO:0006878)2.59401651
121calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.58671879
122protein maturation by protein folding (GO:0022417)2.58084677
123proteasome assembly (GO:0043248)2.57951646
124regulation of metalloenzyme activity (GO:0048552)2.57183041
125wound healing, spreading of epidermal cells (GO:0035313)2.56486006
126paraxial mesoderm development (GO:0048339)2.55729730
127protein localization to kinetochore (GO:0034501)2.55637199
128wound healing, spreading of cells (GO:0044319)2.55628841
129cysteine metabolic process (GO:0006534)2.54816313
130sister chromatid segregation (GO:0000819)2.53814033
131positive regulation of macrophage activation (GO:0043032)2.53696176
132regulation of chromosome segregation (GO:0051983)2.53409691
133alpha-linolenic acid metabolic process (GO:0036109)2.52787522
134retina vasculature morphogenesis in camera-type eye (GO:0061299)2.52531604
135cullin deneddylation (GO:0010388)2.52506000
136membrane raft organization (GO:0031579)2.52463612
137mitochondrial DNA metabolic process (GO:0032042)2.52055646
138polarized epithelial cell differentiation (GO:0030859)2.51474072
139cellular modified amino acid biosynthetic process (GO:0042398)2.51458458
140signal peptide processing (GO:0006465)2.50628744
141NADP metabolic process (GO:0006739)2.50247940
142protein N-linked glycosylation via asparagine (GO:0018279)2.50095171
143folic acid-containing compound biosynthetic process (GO:0009396)2.49662176
144regulation of spindle organization (GO:0090224)2.49090722
145peptidyl-asparagine modification (GO:0018196)2.48965211
146cytoskeleton-dependent cytokinesis (GO:0061640)2.48642671
147negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.48209757
148sterol metabolic process (GO:0016125)2.47934661
149protein hydroxylation (GO:0018126)2.46545513
150membrane budding (GO:0006900)2.46051465
151cellular response to vitamin D (GO:0071305)2.45871539
152glomerular visceral epithelial cell development (GO:0072015)2.45629706
153desmosome organization (GO:0002934)2.45093028
154apical protein localization (GO:0045176)2.45004124
155lipopolysaccharide biosynthetic process (GO:0009103)2.44661412
156primary alcohol catabolic process (GO:0034310)2.44624194
157short-chain fatty acid metabolic process (GO:0046459)2.44195559
158drug transmembrane transport (GO:0006855)2.43749841
159response to redox state (GO:0051775)2.41137467
160* sphingosine metabolic process (GO:0006670)2.40143591
161negative regulation of keratinocyte proliferation (GO:0010839)2.39967752
162protein retention in ER lumen (GO:0006621)2.39332287
163L-amino acid import (GO:0043092)2.38459143
164nucleobase-containing small molecule interconversion (GO:0015949)2.38119415
165negative regulation of protein localization to plasma membrane (GO:1903077)2.37948266
166DNA unwinding involved in DNA replication (GO:0006268)2.37005040
167positive regulation of osteoblast proliferation (GO:0033690)2.36994301
168mammary gland epithelial cell proliferation (GO:0033598)2.36578926
169regulation of axon regeneration (GO:0048679)2.35400910
170regulation of neuron projection regeneration (GO:0070570)2.35400910
171gap junction assembly (GO:0016264)2.35130881
172carbohydrate derivative transport (GO:1901264)2.34486717
173Leydig cell differentiation (GO:0033327)2.33366425
174regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.33083700
175membrane protein intracellular domain proteolysis (GO:0031293)2.32730111
176positive regulation of glial cell differentiation (GO:0045687)2.32311056
177* sphingoid metabolic process (GO:0046519)2.30636305
178regulation of mitotic metaphase/anaphase transition (GO:0030071)2.30545331
179regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.30545331
180ethanol oxidation (GO:0006069)2.30297674
181antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.30122973
182antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.30122973
183protein N-linked glycosylation (GO:0006487)2.29846628
184regulation of collateral sprouting (GO:0048670)2.29306764
185alditol phosphate metabolic process (GO:0052646)2.28485701
186negative regulation of DNA repair (GO:0045738)2.28356090
187neuron remodeling (GO:0016322)2.27769642
188neutrophil activation involved in immune response (GO:0002283)2.27373197
189epithelial cell-cell adhesion (GO:0090136)2.27260610
190GPI anchor biosynthetic process (GO:0006506)2.26871997
191positive regulation of interleukin-17 production (GO:0032740)2.26866576
192peptidyl-proline hydroxylation (GO:0019511)2.26589230
193DNA duplex unwinding (GO:0032508)2.26476923
194acetyl-CoA metabolic process (GO:0006084)2.26294580

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.79264707
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.79180663
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.05412547
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.75154255
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.41752918
6GATA1_22025678_ChIP-Seq_K562_Human3.26959383
7STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.86212722
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.84544113
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.66228948
10RXR_22158963_ChIP-Seq_LIVER_Mouse2.64969551
11PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.59960897
12KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.59298690
13FOXO3_23340844_ChIP-Seq_DLD1_Human2.55122895
14PPARA_22158963_ChIP-Seq_LIVER_Mouse2.47237398
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.37523412
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.35364313
17ELK1_19687146_ChIP-ChIP_HELA_Human2.33864606
18RBPJ_22232070_ChIP-Seq_NCS_Mouse2.31060236
19LXR_22158963_ChIP-Seq_LIVER_Mouse2.29431930
20FOXM1_23109430_ChIP-Seq_U2OS_Human2.27937407
21PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.23914805
22SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.17786486
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.16214253
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.12887922
25MYC_18555785_ChIP-Seq_MESCs_Mouse2.11807045
26EGR1_23403033_ChIP-Seq_LIVER_Mouse2.10684617
27PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.10143898
28SALL1_21062744_ChIP-ChIP_HESCs_Human2.05505122
29CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.04094953
30SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.03234065
31CLOCK_20551151_ChIP-Seq_293T_Human2.00090258
32DCP1A_22483619_ChIP-Seq_HELA_Human1.96935057
33KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.94442935
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.92166343
35IRF8_21731497_ChIP-ChIP_J774_Mouse1.92030367
36SOX2_27498859_Chip-Seq_STOMACH_Mouse1.91784004
37PADI4_21655091_ChIP-ChIP_MCF-7_Human1.91652462
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.84082900
39NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.83157773
40CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.81015478
41GABP_17652178_ChIP-ChIP_JURKAT_Human1.79644454
42CREB1_15753290_ChIP-ChIP_HEK293T_Human1.78223966
43P63_26484246_Chip-Seq_KERATINOCYTES_Human1.78218909
44MYCN_18555785_ChIP-Seq_MESCs_Mouse1.77373385
45EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.76310281
46AR_21909140_ChIP-Seq_LNCAP_Human1.74901032
47SOX2_20726797_ChIP-Seq_SW620_Human1.73706998
48ZNF263_19887448_ChIP-Seq_K562_Human1.71179273
49TRIM28_21343339_ChIP-Seq_HEK293_Human1.67877161
50BRD4_25478319_ChIP-Seq_HGPS_Human1.63238144
51PPAR_26484153_Chip-Seq_NCI-H1993_Human1.63148016
52PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.59895307
53ZFX_18555785_ChIP-Seq_MESCs_Mouse1.59348695
54MYC_19030024_ChIP-ChIP_MESCs_Mouse1.59222099
55RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.54109358
56* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.53668219
57SMAD_19615063_ChIP-ChIP_OVARY_Human1.53579706
58STAT6_21828071_ChIP-Seq_BEAS2B_Human1.52608759
59ESR2_21235772_ChIP-Seq_MCF-7_Human1.51664490
60* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.50634408
61HIF1A_21447827_ChIP-Seq_MCF-7_Human1.50222941
62E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.46980674
63GATA4_25053715_ChIP-Seq_YYC3_Human1.46693995
64HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45900717
65EOMES_21245162_ChIP-Seq_HESCs_Human1.45077601
66NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.40182469
67IRF8_22096565_ChIP-ChIP_GC-B_Human1.40042131
68YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36912230
69ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.35058279
70SALL4_18804426_ChIP-ChIP_XEN_Mouse1.34482036
71E2F1_21310950_ChIP-Seq_MCF-7_Human1.34318869
72* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.32273482
73CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.30773952
74MYC_19079543_ChIP-ChIP_MESCs_Mouse1.29921577
75PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.26854949
76FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.26695606
77TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26342039
78ERG_20887958_ChIP-Seq_HPC-7_Mouse1.25656295
79CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.25143859
80ELK1_22589737_ChIP-Seq_MCF10A_Human1.24533242
81ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23344591
82CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.22308810
83POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.21869882
84NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.21545775
85ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.21277150
86EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.20670546
87ESR1_21235772_ChIP-Seq_MCF-7_Human1.18967454
88NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.18440331
89NRF2_20460467_ChIP-Seq_MEFs_Mouse1.18440331
90HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.17222456
91CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.17201469
92* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.16861807
93IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.16487433
94* VDR_23849224_ChIP-Seq_CD4+_Human1.15818647
95IRF8_27001747_Chip-Seq_BMDM_Mouse1.13549232
96POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.13405264
97ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.12644624
98MYC_18358816_ChIP-ChIP_MESCs_Mouse1.12196842
99CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.11654617
100SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.11585532
101NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.09676731
102* GABP_19822575_ChIP-Seq_HepG2_Human1.09290934
103FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08916382
104SOX9_24532713_ChIP-Seq_HFSC_Mouse1.08316988
105AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.07127092
106STAT4_19710469_ChIP-ChIP_TH1__Mouse1.07093841
107* ETS1_20019798_ChIP-Seq_JURKAT_Human1.06689887
108ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.06472130
109SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04591680
110IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.03011387
111RUNX_20019798_ChIP-Seq_JUKART_Human1.01940127
112WT1_19549856_ChIP-ChIP_CCG9911_Human1.01748558
113ELF5_23300383_ChIP-Seq_T47D_Human1.01509137
114MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.01011767
115HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.00971763
116MYB_21317192_ChIP-Seq_ERMYB_Mouse1.00020893
117TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99952102
118GATA3_26560356_Chip-Seq_TH2_Human0.99763272
119SOX17_20123909_ChIP-Seq_XEN_Mouse0.99758260
120FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.99501714
121GATA1_19941826_ChIP-Seq_K562_Human0.98616693
122HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98362905
123KLF4_18555785_ChIP-Seq_MESCs_Mouse0.98356605
124SRF_21415370_ChIP-Seq_HL-1_Mouse0.97516133
125MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.97142331
126* FOXP3_21729870_ChIP-Seq_TREG_Human0.95983409
127FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.95857552
128GATA3_24758297_ChIP-Seq_MCF-7_Human0.95603014
129ELF1_17652178_ChIP-ChIP_JURKAT_Human0.95395667
130Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.94016449
131SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.93378766
132SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.93378766
133IRF1_19129219_ChIP-ChIP_H3396_Human0.92999862
134NANOG_18555785_ChIP-Seq_MESCs_Mouse0.92609491
135TFEB_21752829_ChIP-Seq_HELA_Human0.92525552
136HTT_18923047_ChIP-ChIP_STHdh_Human0.92457514
137CJUN_26792858_Chip-Seq_BT549_Human0.91704491
138* SPI1_23547873_ChIP-Seq_NB4_Human0.91249047
139NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.90466740
140GATA3_27048872_Chip-Seq_THYMUS_Human0.89937369
141CHD1_26751641_Chip-Seq_LNCaP_Human0.89102303
142SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.88521671
143* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.88365070
144AUTS2_25519132_ChIP-Seq_293T-REX_Human0.87208573
145GATA4_21415370_ChIP-Seq_HL-1_Mouse0.87169784
146NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.86501268
147ZNF217_24962896_ChIP-Seq_MCF-7_Human0.86280701
148ATF3_27146783_Chip-Seq_COLON_Human0.86026949
149FOXA1_25552417_ChIP-Seq_VCAP_Human0.85877031
150FLI1_27457419_Chip-Seq_LIVER_Mouse0.85422153
151MYB_26560356_Chip-Seq_TH2_Human0.85398434
152FOXA1_21572438_ChIP-Seq_LNCaP_Human0.85201517
153TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84138811
154KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.83117225
155ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.82858990
156TP63_23658742_ChIP-Seq_EP156T_Human0.82625813
157NANOG_18692474_ChIP-Seq_MEFs_Mouse0.81794233
158GATA6_25053715_ChIP-Seq_YYC3_Human0.81399757
159STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.80809415
160JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79857990
161SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.79247946
162EST1_17652178_ChIP-ChIP_JURKAT_Human0.78853417

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.31576966
2MP0003950_abnormal_plasma_membrane4.00622437
3MP0000920_abnormal_myelination3.50327091
4MP0003941_abnormal_skin_development3.45799801
5MP0009840_abnormal_foam_cell3.27370262
6MP0005451_abnormal_body_composition3.13737288
7MP0010352_gastrointestinal_tract_polyps3.06976675
8MP0005058_abnormal_lysosome_morphology3.04181648
9MP0010234_abnormal_vibrissa_follicle2.97927194
10MP0002796_impaired_skin_barrier2.79740219
11MP0010678_abnormal_skin_adnexa2.77038820
12MP0002877_abnormal_melanocyte_morpholog2.72680428
13MP0003191_abnormal_cellular_cholesterol2.66197643
14MP0008438_abnormal_cutaneous_collagen2.51949395
15MP0005360_urolithiasis2.48290027
16MP0004957_abnormal_blastocyst_morpholog2.40124647
17MP0000465_gastrointestinal_hemorrhage2.36162453
18MP0000383_abnormal_hair_follicle2.32597483
19MP0010094_abnormal_chromosome_stability2.30248945
20MP0003693_abnormal_embryo_hatching2.26956957
21MP0002139_abnormal_hepatobiliary_system2.10607715
22MP0008057_abnormal_DNA_replication2.03508077
23MP0009697_abnormal_copulation2.01419818
24MP0005257_abnormal_intraocular_pressure1.99360897
25MP0008875_abnormal_xenobiotic_pharmacok1.93974570
26MP0003690_abnormal_glial_cell1.93530560
27MP0006054_spinal_hemorrhage1.88709319
28MP0009384_cardiac_valve_regurgitation1.86263417
29MP0008007_abnormal_cellular_replicative1.83629721
30MP0004185_abnormal_adipocyte_glucose1.79504445
31MP0004381_abnormal_hair_follicle1.78734386
32MP0003111_abnormal_nucleus_morphology1.77907156
33MP0008932_abnormal_embryonic_tissue1.77248568
34MP0005501_abnormal_skin_physiology1.75242784
35MP0004264_abnormal_extraembryonic_tissu1.73633461
36MP0000604_amyloidosis1.73551664
37MP0002060_abnormal_skin_morphology1.69098646
38MP0003453_abnormal_keratinocyte_physiol1.68501218
39MP0004947_skin_inflammation1.67643659
40MP0003077_abnormal_cell_cycle1.67373690
41MP0000647_abnormal_sebaceous_gland1.63130847
42MP0003329_amyloid_beta_deposits1.62219687
43MP0005408_hypopigmentation1.60939972
44MP0002098_abnormal_vibrissa_morphology1.51459276
45MP0000377_abnormal_hair_follicle1.50377585
46MP0009780_abnormal_chondrocyte_physiolo1.47328934
47MP0008058_abnormal_DNA_repair1.47207751
48MP0003656_abnormal_erythrocyte_physiolo1.45127689
49MP0001216_abnormal_epidermal_layer1.44484671
50MP0001666_abnormal_nutrient_absorption1.43414276
51MP0001730_embryonic_growth_arrest1.40116876
52MP0001915_intracranial_hemorrhage1.38943656
53MP0003136_yellow_coat_color1.38640648
54MP0001851_eye_inflammation1.37925150
55MP0005365_abnormal_bile_salt1.35881147
56MP0006082_CNS_inflammation1.35246389
57MP0004043_abnormal_pH_regulation1.35147427
58MP0005332_abnormal_amino_acid1.34386995
59MP0010771_integument_phenotype1.32758144
60MP0001958_emphysema1.31766489
61MP0003724_increased_susceptibility_to1.28716514
62MP0003300_gastrointestinal_ulcer1.24798298
63MP0010368_abnormal_lymphatic_system1.24633309
64MP0004782_abnormal_surfactant_physiolog1.23713788
65MP0005275_abnormal_skin_tensile1.22468211
66MP0002086_abnormal_extraembryonic_tissu1.18274933
67MP0000467_abnormal_esophagus_morphology1.18126405
68MP0001672_abnormal_embryogenesis/_devel1.17443646
69MP0005380_embryogenesis_phenotype1.17443646
70MP0010307_abnormal_tumor_latency1.16549402
71MP0009643_abnormal_urine_homeostasis1.15833392
72MP0003195_calcinosis1.15547908
73MP0003718_maternal_effect1.14483334
74MP0001346_abnormal_lacrimal_gland1.13265777
75MP0004233_abnormal_muscle_weight1.13180809
76MP0003705_abnormal_hypodermis_morpholog1.11563115
77MP0004885_abnormal_endolymph1.11471144
78MP0003091_abnormal_cell_migration1.11339854
79MP0000350_abnormal_cell_proliferation1.10904068
80MP0003984_embryonic_growth_retardation1.10811348
81MP0000685_abnormal_immune_system1.10758013
82MP0005621_abnormal_cell_physiology1.10404376
83MP0004272_abnormal_basement_membrane1.07127715
84MP0002088_abnormal_embryonic_growth/wei1.07078888
85MP0001243_abnormal_dermal_layer1.06876148
86MP0001697_abnormal_embryo_size1.06831058
87MP0001661_extended_life_span1.05386170
88* MP0002118_abnormal_lipid_homeostasis1.05112698
89MP0003221_abnormal_cardiomyocyte_apopto1.04990201
90MP0002084_abnormal_developmental_patter1.04933474
91MP0002295_abnormal_pulmonary_circulatio1.04127974
92MP0001299_abnormal_eye_distance/1.03170042
93MP0005085_abnormal_gallbladder_physiolo1.03046045
94MP0003634_abnormal_glial_cell1.02988076
95MP0000358_abnormal_cell_content/1.01817439
96MP0003186_abnormal_redox_activity1.01540649
97* MP0002080_prenatal_lethality1.01251519
98MP0003786_premature_aging0.98469230
99MP0005384_cellular_phenotype0.97695293
100MP0002896_abnormal_bone_mineralization0.95675404
101MP0002006_tumorigenesis0.95115415
102MP0003172_abnormal_lysosome_physiology0.95065330
103MP0000579_abnormal_nail_morphology0.94755894
104MP0009333_abnormal_splenocyte_physiolog0.94190785
105MP0000627_abnormal_mammary_gland0.93585026
106MP0004147_increased_porphyrin_level0.93229607
107MP0008260_abnormal_autophagy0.91519749
108MP0001191_abnormal_skin_condition0.91290225
109MP0000462_abnormal_digestive_system0.91118507
110MP0002933_joint_inflammation0.90065178
111MP0005076_abnormal_cell_differentiation0.89414967
112MP0000609_abnormal_liver_physiology0.88917600
113MP0004197_abnormal_fetal_growth/weight/0.86765505
114MP0002009_preneoplasia0.85818319
115MP0003448_altered_tumor_morphology0.85461817
116MP0001485_abnormal_pinna_reflex0.84811658
117MP0002419_abnormal_innate_immunity0.84679063
118MP0002254_reproductive_system_inflammat0.83239760
119MP0005025_abnormal_response_to0.83148355
120MP0002085_abnormal_embryonic_tissue0.82847236
121MP0005000_abnormal_immune_tolerance0.82441323
122MP0003385_abnormal_body_wall0.81502079
123MP0010329_abnormal_lipoprotein_level0.80890069
124MP0009931_abnormal_skin_appearance0.80749963
125MP0003566_abnormal_cell_adhesion0.79770797
126MP0001533_abnormal_skeleton_physiology0.77509232
127MP0003632_abnormal_nervous_system0.76446937
128MP0001849_ear_inflammation0.75828620
129MP0000858_altered_metastatic_potential0.74733277
130MP0001873_stomach_inflammation0.73630090
131MP0005623_abnormal_meninges_morphology0.73382630
132MP0002166_altered_tumor_susceptibility0.72750055
133MP0000427_abnormal_hair_cycle0.72566289
134MP0009703_decreased_birth_body0.71860801
135MP0003436_decreased_susceptibility_to0.71541723
136MP0004019_abnormal_vitamin_homeostasis0.70954494
137MP0009765_abnormal_xenobiotic_induced0.70241291
138MP0000537_abnormal_urethra_morphology0.69841975
139MP0005387_immune_system_phenotype0.69359143
140MP0001790_abnormal_immune_system0.69359143
141MP0005083_abnormal_biliary_tract0.68900879
142MP0005503_abnormal_tendon_morphology0.68463262
143MP0009763_increased_sensitivity_to0.67539742
144MP0002723_abnormal_immune_serum0.66921304
145MP0000762_abnormal_tongue_morphology0.66228728
146MP0005023_abnormal_wound_healing0.65555091
147MP0005464_abnormal_platelet_physiology0.65496890
148MP0009672_abnormal_birth_weight0.65447240
149MP0002092_abnormal_eye_morphology0.65293807
150MP0002697_abnormal_eye_size0.64643850
151MP0005508_abnormal_skeleton_morphology0.64111219
152MP0000767_abnormal_smooth_muscle0.63524037
153MP0008469_abnormal_protein_level0.62977522
154MP0005310_abnormal_salivary_gland0.62300042
155MP0005584_abnormal_enzyme/coenzyme_acti0.62240240
156MP0005395_other_phenotype0.61952453
157MP0000747_muscle_weakness0.61840910
158MP0002136_abnormal_kidney_physiology0.61786794

Predicted human phenotypes

RankGene SetZ-score
1Parakeratosis (HP:0001036)5.96409010
2Neurofibrillary tangles (HP:0002185)4.68319008
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.13348969
4Degeneration of the lateral corticospinal tracts (HP:0002314)4.13348969
5Congenital ichthyosiform erythroderma (HP:0007431)3.83970633
6Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.75621750
7Atrophic scars (HP:0001075)3.65670796
8Onycholysis (HP:0001806)3.46487699
9Cerebral inclusion bodies (HP:0100314)3.40379861
10Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.39568991
11Alopecia of scalp (HP:0002293)3.38582602
12Spastic paraparesis (HP:0002313)3.23434886
13Right ventricular cardiomyopathy (HP:0011663)3.23059652
14Vacuolated lymphocytes (HP:0001922)3.14701916
15Intrahepatic cholestasis (HP:0001406)3.12134370
16Protrusio acetabuli (HP:0003179)3.10570843
17Hyperlipoproteinemia (HP:0010980)3.10309733
18Abnormality of aromatic amino acid family metabolism (HP:0004338)3.09839314
19Increased neuronal autofluorescent lipopigment (HP:0002074)3.04534385
20Sensory axonal neuropathy (HP:0003390)3.00441882
21Selective tooth agenesis (HP:0001592)2.98146989
22Arterial tortuosity (HP:0005116)2.97827020
23Vascular tortuosity (HP:0004948)2.96132294
24Plantar hyperkeratosis (HP:0007556)2.93417525
25Erythroderma (HP:0001019)2.91642450
26Follicular hyperkeratosis (HP:0007502)2.90699360
27Increased serum pyruvate (HP:0003542)2.84519922
28Abnormality of glycolysis (HP:0004366)2.84519922
29Increased cerebral lipofuscin (HP:0011813)2.83784657
30Premature rupture of membranes (HP:0001788)2.82101546
31Premature skin wrinkling (HP:0100678)2.80224217
32Stridor (HP:0010307)2.79557023
33Abnormality of oral frenula (HP:0000190)2.76309790
34Hepatosplenomegaly (HP:0001433)2.75766042
35Entropion (HP:0000621)2.72088723
36Ankyloglossia (HP:0010296)2.70468261
37Termporal pattern (HP:0011008)2.70137971
38Insidious onset (HP:0003587)2.70137971
39Fragile skin (HP:0001030)2.67285404
40Palmar hyperkeratosis (HP:0010765)2.63238495
41Abnormality of nail color (HP:0100643)2.63108401
42Palmoplantar hyperkeratosis (HP:0000972)2.61390113
43Papillary thyroid carcinoma (HP:0002895)2.59923431
44Abnormality of macrophages (HP:0004311)2.55013018
45Deep venous thrombosis (HP:0002625)2.54463102
46Hypokalemic alkalosis (HP:0001949)2.53759767
47Xanthomatosis (HP:0000991)2.53321054
48Loss of speech (HP:0002371)2.53252594
49Ankle contracture (HP:0006466)2.52023335
50Hypoplastic pelvis (HP:0008839)2.47208991
51Aortic dissection (HP:0002647)2.45011212
52Chronic otitis media (HP:0000389)2.42887678
53Cortical dysplasia (HP:0002539)2.41553772
54Prolonged neonatal jaundice (HP:0006579)2.41204287
55Microglossia (HP:0000171)2.34180241
56Abnormality of the corticospinal tract (HP:0002492)2.32344417
57Pustule (HP:0200039)2.29069528
58Wormian bones (HP:0002645)2.27660468
59Sparse eyelashes (HP:0000653)2.26734114
60Vertebral compression fractures (HP:0002953)2.24625798
61Cervical subluxation (HP:0003308)2.24490955
62Abnormality of glycine metabolism (HP:0010895)2.24405178
63Abnormality of serine family amino acid metabolism (HP:0010894)2.24405178
64Chromosomal breakage induced by crosslinking agents (HP:0003221)2.24184097
65Pili torti (HP:0003777)2.23305970
66Soft skin (HP:0000977)2.21326920
67Bladder diverticulum (HP:0000015)2.20669384
68Natal tooth (HP:0000695)2.20428527
69Abnormalities of placenta or umbilical cord (HP:0001194)2.19002537
70Metabolic alkalosis (HP:0200114)2.13825582
71Chromsome breakage (HP:0040012)2.13237141
72Abnormality of aspartate family amino acid metabolism (HP:0010899)2.12599055
73Orthostatic hypotension (HP:0001278)2.12466490
74Blepharitis (HP:0000498)2.12026325
75Osteolytic defects of the phalanges of the hand (HP:0009771)2.10868500
76Osteolytic defects of the hand bones (HP:0009699)2.10868500
77Dysostosis multiplex (HP:0000943)2.10452562
78Fragile nails (HP:0001808)2.09852487
79Progressive neurologic deterioration (HP:0002344)2.09082629
80Tetraparesis (HP:0002273)2.08264016
81Thyroid carcinoma (HP:0002890)2.07963518
82Peripheral hypomyelination (HP:0007182)2.07265113
83Seborrheic dermatitis (HP:0001051)2.05976404
84Abnormality of placental membranes (HP:0011409)2.03833682
85Amniotic constriction ring (HP:0009775)2.03833682
86Steatorrhea (HP:0002570)2.03767189
87Fat malabsorption (HP:0002630)2.02690454
88Decreased skull ossification (HP:0004331)2.01486490
89Abnormality of the umbilical cord (HP:0010881)2.01309125
90Septate vagina (HP:0001153)2.00448055
91Delayed closure of the anterior fontanelle (HP:0001476)2.00390485
92Clitoromegaly (HP:0000057)2.00278707
93Hypoplasia of the iris (HP:0007676)1.98435757
94Spastic diplegia (HP:0001264)1.97941778
95Pterygium (HP:0001059)1.97558694
96Nail dystrophy (HP:0008404)1.94995163
97Cerebral hypomyelination (HP:0006808)1.94769709
98Milia (HP:0001056)1.94519475
99Periodontitis (HP:0000704)1.94499407
100Abnormality of the distal phalanges of the toes (HP:0010182)1.93874424
101Deviation of the thumb (HP:0009603)1.93874030
102Abnormal auditory evoked potentials (HP:0006958)1.93847637
103Purpura (HP:0000979)1.92861577
104Deep philtrum (HP:0002002)1.92640770
105Asymmetry of the thorax (HP:0001555)1.91315081
106Curly hair (HP:0002212)1.91313236
107Paraparesis (HP:0002385)1.90989460
108Esophageal atresia (HP:0002032)1.89441798
109Increased circulating renin level (HP:0000848)1.88764504
110Amyloidosis (HP:0011034)1.88550195
111Thick nail (HP:0001805)1.88308998
112Breech presentation (HP:0001623)1.87908364
113Protuberant abdomen (HP:0001538)1.87143692
114Hand muscle atrophy (HP:0009130)1.86733559
115Increased nuchal translucency (HP:0010880)1.85936176
116Abnormal delivery (HP:0001787)1.85819235
117Insomnia (HP:0100785)1.85509291
118Coronal craniosynostosis (HP:0004440)1.84876854
119Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.83596937
120Clumsiness (HP:0002312)1.83046027
121Malnutrition (HP:0004395)1.82412463
122Abnormality of monocarboxylic acid metabolism (HP:0010996)1.82372729
123Absent eyelashes (HP:0000561)1.81358095
124Abnormal hair laboratory examination (HP:0003328)1.80796226
125Cerebral hemorrhage (HP:0001342)1.79572237
126Upper limb muscle weakness (HP:0003484)1.79082503
127Hypokinesia (HP:0002375)1.78869838
128Ectropion (HP:0000656)1.78678651
129Hematochezia (HP:0002573)1.76528280
130Gastrointestinal stroma tumor (HP:0100723)1.74345205
131Subacute progressive viral hepatitis (HP:0006572)1.74312360
132Thin skin (HP:0000963)1.73993146
133Nonimmune hydrops fetalis (HP:0001790)1.73898561
134Erythema (HP:0010783)1.72757393
135Onion bulb formation (HP:0003383)1.72644396
136Segmental peripheral demyelination/remyelination (HP:0003481)1.72360193
137Stenosis of the external auditory canal (HP:0000402)1.72168984
138Hypomagnesemia (HP:0002917)1.72080719
139Abnormal umbilical cord blood vessels (HP:0011403)1.71868914
140Single umbilical artery (HP:0001195)1.71868914
141Abnormality of the fetal cardiovascular system (HP:0010948)1.71868914
142Anteriorly placed anus (HP:0001545)1.71470355
143Humeroradial synostosis (HP:0003041)1.71380605
144Synostosis involving the elbow (HP:0003938)1.71380605
145Interstitial pulmonary disease (HP:0006530)1.71304589
146Ependymoma (HP:0002888)1.71072046
147Relative macrocephaly (HP:0004482)1.71040646
148Abnormality of the acetabulum (HP:0003170)1.69936976
149Cholecystitis (HP:0001082)1.69903102
150Abnormal gallbladder physiology (HP:0012438)1.69903102
151Abnormal tarsal ossification (HP:0008369)1.69760897
152Abnormality of skull ossification (HP:0002703)1.69750587
153Ulnar bowing (HP:0003031)1.69577190
154Secondary amenorrhea (HP:0000869)1.69565671
155Increased serum ferritin (HP:0003281)1.69328255
156Patchy hypopigmentation of hair (HP:0011365)1.68797298
157Dilatation of the ascending aorta (HP:0005111)1.68090831
158Cutaneous melanoma (HP:0012056)1.68084066
159Hyperglycinuria (HP:0003108)1.67869705
160Short middle phalanx of the 5th finger (HP:0004220)1.66902249
161Spinal rigidity (HP:0003306)1.66590198
162Freckling (HP:0001480)1.66495073
163Supranuclear gaze palsy (HP:0000605)1.66161681
164Microvesicular hepatic steatosis (HP:0001414)1.66097664
165Postnatal microcephaly (HP:0005484)1.66084397
166Abnormality of methionine metabolism (HP:0010901)1.65364011
167Axonal loss (HP:0003447)1.65047852
168Adrenal hypoplasia (HP:0000835)1.64509697
169Abnormality of the lumbar spine (HP:0100712)1.64479726
170Advanced eruption of teeth (HP:0006288)1.64249043
171Proximal placement of thumb (HP:0009623)1.62890759
172Delayed cranial suture closure (HP:0000270)1.62850607
173Mitral stenosis (HP:0001718)1.62411687
174Hoarse voice (HP:0001609)1.62388802
175Peritonitis (HP:0002586)1.61816952
176Corneal erosion (HP:0200020)1.61008132
177Abnormal foot bone ossification (HP:0010675)1.60992064
178Lack of skin elasticity (HP:0100679)1.60946638
179Persistence of primary teeth (HP:0006335)1.60330062
180Squamous cell carcinoma (HP:0002860)1.60056973
181Conjunctival telangiectasia (HP:0000524)1.59058846
182Partial duplication of thumb phalanx (HP:0009944)1.58405800
183Macrocytic anemia (HP:0001972)1.58259474
184Nephroblastoma (Wilms tumor) (HP:0002667)1.56444346
185Palpitations (HP:0001962)1.56434432
186Abnormality of dentin (HP:0010299)1.56295473
187Cardiovascular calcification (HP:0011915)1.55276378
188Neoplasm of the peripheral nervous system (HP:0100007)1.54206067
189Skull defect (HP:0001362)1.53913626

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.54896623
2OXSR13.83229636
3EPHB13.59814725
4MST43.41643590
5TSSK63.02591024
6EIF2AK12.74681119
7TRPM72.72656621
8MAPKAPK52.67985425
9STK102.65460975
10TTK2.61189239
11MET2.59346784
12NEK12.32036126
13MAP3K122.19787695
14SRPK12.06136349
15PAK41.97133210
16KDR1.87290126
17WNK41.77913917
18CDK191.76623077
19STK38L1.74399833
20LRRK21.73576521
21PDGFRA1.73425061
22MAPKAPK31.73085714
23MAP3K131.71566374
24ITK1.69430756
25PBK1.67428182
26TESK21.67030379
27PDK21.66880053
28ERBB31.64419081
29ERBB41.61983701
30EEF2K1.61854215
31BRSK21.61176897
32MAP4K11.57323462
33TRIM281.52125386
34LATS21.47581485
35BCR1.47546842
36MOS1.46515993
37CSNK1A1L1.45432295
38FGFR21.44419841
39MAP2K21.40785287
40CSNK1G31.38546001
41CSNK1G11.37182879
42RPS6KA41.35316149
43PLK31.34493844
44BCKDK1.32539473
45RPS6KB21.29703002
46EPHA21.25234843
47LATS11.22325221
48PKN11.21369244
49KIT1.20224681
50FGFR41.20049021
51MAP3K31.17129898
52NEK61.16866715
53NEK91.13706870
54BRD41.13356419
55KSR11.11813925
56PTK21.10665497
57BUB11.10399039
58MKNK11.09849345
59LIMK11.09745516
60CDK61.09356557
61CSNK1G21.07769222
62MYLK1.07579224
63MST1R1.05076882
64ROCK21.04944495
65NTRK11.03934410
66FGR1.03670897
67MAP3K80.98240492
68CDK120.98158839
69BMPR20.96883310
70PDGFRB0.93439092
71CSK0.92809443
72MELK0.92713895
73KSR20.92636951
74EIF2AK30.85326426
75NLK0.85260905
76ERN10.84947897
77LMTK20.84790131
78PLK40.84227618
79PLK20.84151774
80EPHA30.84097204
81IRAK40.81320692
82TAOK30.81116274
83BRSK10.80814363
84BLK0.80437867
85STK240.77876961
86AKT30.77547614
87FGFR10.77190573
88AURKB0.77123382
89MAP3K110.76003877
90PRKD10.75421596
91PLK10.75010116
92MKNK20.74760415
93TGFBR20.73802028
94GSK3A0.73195505
95ARAF0.73152138
96TIE10.72183530
97PRKCQ0.71374560
98STK30.69811541
99ALK0.69402058
100LCK0.68477299
101RAF10.68286733
102CSF1R0.68198093
103RIPK10.67809642
104TYRO30.66928479
105JAK30.66851748
106MAPK150.66193035
107PAK30.65957713
108STK40.65820335
109SCYL20.62951345
110EIF2AK20.62761626
111BTK0.61520960
112SIK30.61115939
113MUSK0.60766423
114ZAP700.60631588
115TYK20.60609273
116ATM0.58540732
117CHEK10.58540081
118CLK10.58021467
119FER0.57870606
120ACVR1B0.55850015
121CDK90.54823426
122WNK10.54437873
123PAK20.54195442
124PTK60.52661075
125PIM20.52210854
126CAMK2B0.51709626
127GRK60.50951659
128CDK70.50590913
129RPS6KA50.50030123
130TEC0.49937241
131MAP3K140.49854784
132STK160.49804206
133CDC70.49549050
134PDPK10.48146000
135FYN0.47367680
136CAMK2G0.46960376
137YES10.45214115
138WEE10.44607971
139ICK0.44498586
140EGFR0.44484661
141PAK10.44031413
142BMX0.41947919
143TGFBR10.41812734
144MAP3K10.40940222
145IKBKB0.40310672
146CDK80.39904765
147JAK10.39466521
148MAP3K90.39268637
149TAF10.39193586
150TBK10.39035644
151CAMK2D0.38437677
152NEK20.36828932
153PRKCI0.36635288
154* ABL10.36493439
155ABL20.36446899
156IGF1R0.36364305
157MAPKAPK20.36275136
158HCK0.36246021
159INSR0.36156069
160MAP3K20.35553492
161PAK60.35395993
162BMPR1B0.35060441
163AKT20.35046624
164DYRK30.34973439
165PRKG20.31704625

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001004.08586466
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.85646827
3Fatty acid elongation_Homo sapiens_hsa000623.57134929
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.42873942
5Histidine metabolism_Homo sapiens_hsa003402.77170807
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.75243394
7Sulfur metabolism_Homo sapiens_hsa009202.63971610
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.50395671
9Folate biosynthesis_Homo sapiens_hsa007902.37850593
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.29719359
11Ether lipid metabolism_Homo sapiens_hsa005652.23121705
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.20198186
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.16845312
14Vitamin B6 metabolism_Homo sapiens_hsa007502.15647968
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.12951694
16Protein export_Homo sapiens_hsa030602.08825266
17Mismatch repair_Homo sapiens_hsa034302.03796784
18Nitrogen metabolism_Homo sapiens_hsa009101.99815858
19DNA replication_Homo sapiens_hsa030301.97539041
20RNA transport_Homo sapiens_hsa030131.80587683
21Nucleotide excision repair_Homo sapiens_hsa034201.76705580
22N-Glycan biosynthesis_Homo sapiens_hsa005101.72869358
23Peroxisome_Homo sapiens_hsa041461.67291737
24Cell cycle_Homo sapiens_hsa041101.65441639
25Butanoate metabolism_Homo sapiens_hsa006501.63858113
26Glutathione metabolism_Homo sapiens_hsa004801.62088789
27Fatty acid degradation_Homo sapiens_hsa000711.60430759
28Adherens junction_Homo sapiens_hsa045201.60417858
29Lysosome_Homo sapiens_hsa041421.60243628
30Caffeine metabolism_Homo sapiens_hsa002321.59066924
31One carbon pool by folate_Homo sapiens_hsa006701.58338342
32Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.58329836
33* Sphingolipid metabolism_Homo sapiens_hsa006001.58106141
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.56860293
35Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.56507342
36Arginine and proline metabolism_Homo sapiens_hsa003301.53970266
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.52370771
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.47968249
39Linoleic acid metabolism_Homo sapiens_hsa005911.47364605
40Fatty acid metabolism_Homo sapiens_hsa012121.46722195
41Thyroid cancer_Homo sapiens_hsa052161.45874799
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.43698792
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.42396896
44Propanoate metabolism_Homo sapiens_hsa006401.41967567
45Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.37245057
46Primary bile acid biosynthesis_Homo sapiens_hsa001201.35315673
47Vitamin digestion and absorption_Homo sapiens_hsa049771.33845885
48Sulfur relay system_Homo sapiens_hsa041221.32073854
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.26539801
50p53 signaling pathway_Homo sapiens_hsa041151.23488130
51beta-Alanine metabolism_Homo sapiens_hsa004101.19904596
522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.17456925
53Central carbon metabolism in cancer_Homo sapiens_hsa052301.15458766
54Proteoglycans in cancer_Homo sapiens_hsa052051.15065707
55Spliceosome_Homo sapiens_hsa030401.14927075
56Selenocompound metabolism_Homo sapiens_hsa004501.10667908
57Tryptophan metabolism_Homo sapiens_hsa003801.10323753
58Chemical carcinogenesis_Homo sapiens_hsa052041.07650189
59Pentose and glucuronate interconversions_Homo sapiens_hsa000401.05465337
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.04299592
61Base excision repair_Homo sapiens_hsa034101.04027642
62Focal adhesion_Homo sapiens_hsa045101.03961919
63Complement and coagulation cascades_Homo sapiens_hsa046101.03164376
64TGF-beta signaling pathway_Homo sapiens_hsa043501.00380036
65Other glycan degradation_Homo sapiens_hsa005111.00295790
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.94121863
67Proteasome_Homo sapiens_hsa030500.93003229
68PPAR signaling pathway_Homo sapiens_hsa033200.92269702
69Galactose metabolism_Homo sapiens_hsa000520.91307308
70Retinol metabolism_Homo sapiens_hsa008300.90890589
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90631644
72Malaria_Homo sapiens_hsa051440.89567187
73mRNA surveillance pathway_Homo sapiens_hsa030150.88281517
74MicroRNAs in cancer_Homo sapiens_hsa052060.87946674
75Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.87051627
76Bladder cancer_Homo sapiens_hsa052190.86801431
77Staphylococcus aureus infection_Homo sapiens_hsa051500.83399317
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82989168
79ABC transporters_Homo sapiens_hsa020100.82787146
80Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.81523018
81Fanconi anemia pathway_Homo sapiens_hsa034600.81156233
82Fat digestion and absorption_Homo sapiens_hsa049750.78045105
83Fatty acid biosynthesis_Homo sapiens_hsa000610.76950330
84RNA polymerase_Homo sapiens_hsa030200.76909684
85Lysine degradation_Homo sapiens_hsa003100.76198907
86Maturity onset diabetes of the young_Homo sapiens_hsa049500.75952019
87Arachidonic acid metabolism_Homo sapiens_hsa005900.74969605
88Legionellosis_Homo sapiens_hsa051340.74867833
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.72991731
90Pancreatic cancer_Homo sapiens_hsa052120.72699683
91RNA degradation_Homo sapiens_hsa030180.72233196
92Viral carcinogenesis_Homo sapiens_hsa052030.69834337
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.68167866
94Pyrimidine metabolism_Homo sapiens_hsa002400.67713191
95Ribosome_Homo sapiens_hsa030100.66613563
96Pyruvate metabolism_Homo sapiens_hsa006200.66531232
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66206803
98Hippo signaling pathway_Homo sapiens_hsa043900.65836550
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.64636253
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.64209944
101Chronic myeloid leukemia_Homo sapiens_hsa052200.63839547
102Pentose phosphate pathway_Homo sapiens_hsa000300.63644849
103Renin-angiotensin system_Homo sapiens_hsa046140.63216717
104* Metabolic pathways_Homo sapiens_hsa011000.63036973
105ECM-receptor interaction_Homo sapiens_hsa045120.62558189
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62392878
107Drug metabolism - other enzymes_Homo sapiens_hsa009830.61761453
108Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60984091
109Fructose and mannose metabolism_Homo sapiens_hsa000510.60829282
110Mineral absorption_Homo sapiens_hsa049780.60600059
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.59496768
112Non-homologous end-joining_Homo sapiens_hsa034500.56771144
113Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.55606470
114Apoptosis_Homo sapiens_hsa042100.54793521
115Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54779883
116Oocyte meiosis_Homo sapiens_hsa041140.54527585
117AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53870298
118PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53853830
119Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53839200
120Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53316588
121Endometrial cancer_Homo sapiens_hsa052130.53293861
122Amoebiasis_Homo sapiens_hsa051460.52765570
123Glycerolipid metabolism_Homo sapiens_hsa005610.50867702
124Protein digestion and absorption_Homo sapiens_hsa049740.50018703
125Prostate cancer_Homo sapiens_hsa052150.49981719
126HIF-1 signaling pathway_Homo sapiens_hsa040660.46928593
127Glycosaminoglycan degradation_Homo sapiens_hsa005310.46257230
128Salmonella infection_Homo sapiens_hsa051320.46036979
129Pertussis_Homo sapiens_hsa051330.45997622
130Rheumatoid arthritis_Homo sapiens_hsa053230.45451718
131Endocytosis_Homo sapiens_hsa041440.44864715
132Purine metabolism_Homo sapiens_hsa002300.43799057
133Phagosome_Homo sapiens_hsa041450.43001991
134Circadian rhythm_Homo sapiens_hsa047100.40482641
135Tight junction_Homo sapiens_hsa045300.39264464
136Tyrosine metabolism_Homo sapiens_hsa003500.39226405
137Renal cell carcinoma_Homo sapiens_hsa052110.37226867
138Melanoma_Homo sapiens_hsa052180.37034320
139Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.35540536
140Antigen processing and presentation_Homo sapiens_hsa046120.35254414
141SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34697033
142Shigellosis_Homo sapiens_hsa051310.34378921
143Hepatitis B_Homo sapiens_hsa051610.34183623
144Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.33057165
145Cyanoamino acid metabolism_Homo sapiens_hsa004600.32761034
146Vibrio cholerae infection_Homo sapiens_hsa051100.32065198
147Basal transcription factors_Homo sapiens_hsa030220.29267639
148Biosynthesis of amino acids_Homo sapiens_hsa012300.28995466
149Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.28199815
150Oxidative phosphorylation_Homo sapiens_hsa001900.27993238
151Hepatitis C_Homo sapiens_hsa051600.26774932
152Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.25427305
153* Sphingolipid signaling pathway_Homo sapiens_hsa040710.24788058
154Hematopoietic cell lineage_Homo sapiens_hsa046400.24618103
155Small cell lung cancer_Homo sapiens_hsa052220.24270987
156Carbon metabolism_Homo sapiens_hsa012000.24240803

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