SPTBN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein contains an N-terminal actin-binding domain, and 17 spectrin repeats which are involved in dimer formation. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)4.22578852
2regulation of short-term neuronal synaptic plasticity (GO:0048172)4.00320664
3synaptic vesicle maturation (GO:0016188)3.98930666
4vocalization behavior (GO:0071625)3.96466679
5layer formation in cerebral cortex (GO:0021819)3.66156514
6cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.61651832
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.61568220
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.51550016
9synaptic vesicle docking involved in exocytosis (GO:0016081)3.45400544
10glutamate secretion (GO:0014047)3.41983285
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.37438073
12cell communication by electrical coupling (GO:0010644)3.35836977
13regulation of synapse structural plasticity (GO:0051823)3.32329194
14regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.26956439
15activation of protein kinase A activity (GO:0034199)3.22779826
16establishment of nucleus localization (GO:0040023)3.21274170
17regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.21056886
18regulation of glutamate receptor signaling pathway (GO:1900449)3.20618023
19regulation of synaptic vesicle exocytosis (GO:2000300)3.17839963
20positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.17473030
21exploration behavior (GO:0035640)3.14839246
22synaptic vesicle exocytosis (GO:0016079)3.14274032
23membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.14065014
24dendritic spine morphogenesis (GO:0060997)3.10374837
25proline transport (GO:0015824)3.10315011
26hemidesmosome assembly (GO:0031581)3.08373889
27protein localization to synapse (GO:0035418)3.02663348
28regulation of long-term neuronal synaptic plasticity (GO:0048169)3.00563244
29retina vasculature morphogenesis in camera-type eye (GO:0061299)3.00246805
30surfactant homeostasis (GO:0043129)2.97857830
31embryonic retina morphogenesis in camera-type eye (GO:0060059)2.96450812
32cell communication involved in cardiac conduction (GO:0086065)2.95670187
33cell-substrate junction assembly (GO:0007044)2.95631387
34plasma membrane repair (GO:0001778)2.94799247
35cellular sodium ion homeostasis (GO:0006883)2.93694759
36regulation of dendritic spine morphogenesis (GO:0061001)2.92418211
37dendrite morphogenesis (GO:0048813)2.90671534
38sodium ion export (GO:0071436)2.90510130
39regulation of neuronal synaptic plasticity (GO:0048168)2.87731748
40cellular potassium ion homeostasis (GO:0030007)2.86528944
41cytoskeletal anchoring at plasma membrane (GO:0007016)2.86431282
42regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.86293703
43vascular endothelial growth factor signaling pathway (GO:0038084)2.83610484
44regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.83194023
45regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.83130076
46positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.78884812
47adherens junction assembly (GO:0034333)2.75499083
48regulation of synaptic vesicle transport (GO:1902803)2.74130895
49ionotropic glutamate receptor signaling pathway (GO:0035235)2.72275092
50neuron cell-cell adhesion (GO:0007158)2.72208138
51neuron recognition (GO:0008038)2.70948267
52axonal fasciculation (GO:0007413)2.69112055
53neurotransmitter secretion (GO:0007269)2.68646988
54neurotransmitter-gated ion channel clustering (GO:0072578)2.66709341
55focal adhesion assembly (GO:0048041)2.65434697
56cell-substrate adherens junction assembly (GO:0007045)2.65434697
57cardiac myofibril assembly (GO:0055003)2.64502961
58peptidyl-tyrosine autophosphorylation (GO:0038083)2.59160961
59regulation of axon extension involved in axon guidance (GO:0048841)2.58624572
60lymph vessel development (GO:0001945)2.56977092
61positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.55808957
62chemical homeostasis within a tissue (GO:0048875)2.55588620
63endothelium development (GO:0003158)2.55064770
64regulation of membrane repolarization (GO:0060306)2.53730811
65glutamate receptor signaling pathway (GO:0007215)2.53247070
66negative regulation of fatty acid transport (GO:2000192)2.52652301
67potassium ion import (GO:0010107)2.52490467
68positive regulation of potassium ion transmembrane transport (GO:1901381)2.51157424
69positive regulation of axon extension (GO:0045773)2.51142879
70membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.50559412
71vesicle transport along microtubule (GO:0047496)2.50238769
72regulation of excitatory postsynaptic membrane potential (GO:0060079)2.50096324
73innervation (GO:0060384)2.49220763
74amino acid import (GO:0043090)2.48826412
75cerebellar Purkinje cell differentiation (GO:0021702)2.48375737
76neuromuscular process controlling balance (GO:0050885)2.47323097
77myelination in peripheral nervous system (GO:0022011)2.46111994
78peripheral nervous system axon ensheathment (GO:0032292)2.46111994
79long-term memory (GO:0007616)2.45922010
80regulation of ARF protein signal transduction (GO:0032012)2.45550277
81cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.45357382
82axon extension (GO:0048675)2.45352606
83membrane depolarization during action potential (GO:0086010)2.44983512
84synaptic transmission, glutamatergic (GO:0035249)2.43715289
85positive regulation of synapse maturation (GO:0090129)2.43601287
86regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.42851892
87neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.42754047
88regulation of dendritic spine development (GO:0060998)2.42712768
89regulation of cell communication by electrical coupling (GO:0010649)2.42353549
90regulation of postsynaptic membrane potential (GO:0060078)2.42041661
91regulation of calcium ion transmembrane transporter activity (GO:1901019)2.41328316
92regulation of calcium ion transmembrane transport (GO:1903169)2.41328316
93insulin-like growth factor receptor signaling pathway (GO:0048009)2.40959279
94negative regulation of dendrite morphogenesis (GO:0050774)2.40303555
95negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.39444411
96cell migration in hindbrain (GO:0021535)2.38072242
97relaxation of cardiac muscle (GO:0055119)2.38056044
98auditory behavior (GO:0031223)2.36144120
99regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.35881872
100L-amino acid import (GO:0043092)2.35805731
101positive regulation of potassium ion transport (GO:0043268)2.34855899
102neuron-neuron synaptic transmission (GO:0007270)2.34593663
103regulation of axon guidance (GO:1902667)2.33982253
104protein localization to endosome (GO:0036010)2.33321248
105cardiac conduction (GO:0061337)2.33296108
106clathrin coat assembly (GO:0048268)2.31861712
107regulation of synaptic plasticity (GO:0048167)2.31821659
108neuronal action potential propagation (GO:0019227)2.31798539
109organelle transport along microtubule (GO:0072384)2.31267629
110regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.31021441
111semaphorin-plexin signaling pathway (GO:0071526)2.30781394
112regulation of voltage-gated calcium channel activity (GO:1901385)2.30438938
113positive regulation of glucose transport (GO:0010828)2.30127480
114cell adhesion mediated by integrin (GO:0033627)2.29764310
115cerebellar granule cell differentiation (GO:0021707)2.29495878
116regulation of cholesterol homeostasis (GO:2000188)2.29443194
117negative regulation of potassium ion transmembrane transport (GO:1901380)2.28468776
118membrane repolarization during action potential (GO:0086011)2.28402555
119dendritic spine organization (GO:0097061)2.28071807
120synaptic vesicle endocytosis (GO:0048488)2.27953840
121basement membrane organization (GO:0071711)2.27386667
122positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.27213061
123cellular response to epinephrine stimulus (GO:0071872)2.26920410
124regulation of potassium ion transmembrane transporter activity (GO:1901016)2.26799024
125G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.26667805
126positive regulation of cardiac muscle hypertrophy (GO:0010613)2.26343112
127positive regulation of muscle hypertrophy (GO:0014742)2.26343112
128membrane repolarization (GO:0086009)2.26152109
129regulation of potassium ion transmembrane transport (GO:1901379)2.26002839
130lymphangiogenesis (GO:0001946)2.25943926
131negative regulation of cytosolic calcium ion concentration (GO:0051481)2.25923155
132positive regulation of glucose import (GO:0046326)2.24809582
133cell migration involved in sprouting angiogenesis (GO:0002042)2.23455748
134peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.16722153
135astrocyte development (GO:0014002)2.16076237
136negative regulation of vascular permeability (GO:0043116)2.15978143
137protein localization to cell surface (GO:0034394)2.15619831
138cell volume homeostasis (GO:0006884)2.15063280
139cellular response to monoamine stimulus (GO:0071868)2.14625526
140cellular response to catecholamine stimulus (GO:0071870)2.14625526
141vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.11904091
142regulation of transforming growth factor beta2 production (GO:0032909)2.10927317
143neuronal ion channel clustering (GO:0045161)2.09523285
144mating behavior (GO:0007617)2.07770777
145glomerular visceral epithelial cell development (GO:0072015)2.04200936
146regulation of glucose import in response to insulin stimulus (GO:2001273)2.03851593
147morphogenesis of an epithelial sheet (GO:0002011)2.01902133
148cortical actin cytoskeleton organization (GO:0030866)2.01716980
149coronary vasculature morphogenesis (GO:0060977)2.01685804
150hippo signaling (GO:0035329)2.01509476
151regulation of cardioblast differentiation (GO:0051890)2.01471080
152blood vessel endothelial cell migration (GO:0043534)2.00791286
153axon ensheathment in central nervous system (GO:0032291)2.00245559
154central nervous system myelination (GO:0022010)2.00245559
155regulation of steroid hormone biosynthetic process (GO:0090030)1.99434099
156regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)1.99320763
157desmosome organization (GO:0002934)1.99116879
158endothelial cell morphogenesis (GO:0001886)1.99003012
159regulation of cardiac muscle cell contraction (GO:0086004)1.97467624
160renal filtration (GO:0097205)1.96698523
161regulation of synapse maturation (GO:0090128)1.95847205
162gap junction assembly (GO:0016264)1.95484724
163neuromuscular junction development (GO:0007528)1.95312938
164myotube differentiation (GO:0014902)1.94969070
165epithelial cell-cell adhesion (GO:0090136)1.94365041
166regulation of cAMP-dependent protein kinase activity (GO:2000479)1.94333145
167response to epinephrine (GO:0071871)1.93783634
168regulation of calcineurin-NFAT signaling cascade (GO:0070884)1.93521295
169bundle of His cell to Purkinje myocyte communication (GO:0086069)1.93340001
170negative regulation of catenin import into nucleus (GO:0035414)1.92265310

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.74237514
2GBX2_23144817_ChIP-Seq_PC3_Human2.93659067
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.66012769
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.55029673
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.47151011
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.39667064
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.39667064
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.33764267
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.32061055
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.24338123
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.22989238
12DROSHA_22980978_ChIP-Seq_HELA_Human2.13669407
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.13392605
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.13171663
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.06049314
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.03087512
17SMAD_19615063_ChIP-ChIP_OVARY_Human1.99378793
18EZH2_27304074_Chip-Seq_ESCs_Mouse1.98743499
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.94859520
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.94201541
21EP300_21415370_ChIP-Seq_HL-1_Mouse1.93497492
22TRIM28_21343339_ChIP-Seq_HEK293_Human1.93254183
23CLOCK_20551151_ChIP-Seq_293T_Human1.88919931
24CDX2_19796622_ChIP-Seq_MESCs_Mouse1.86665956
25NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.83318079
26RNF2_27304074_Chip-Seq_ESCs_Mouse1.83087072
27* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.78378629
28AR_21572438_ChIP-Seq_LNCaP_Human1.75734351
29ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.70619214
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.68819214
31RARG_19884340_ChIP-ChIP_MEFs_Mouse1.67481830
32RARB_27405468_Chip-Seq_BRAIN_Mouse1.63563725
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.63147210
34* FOXA2_19822575_ChIP-Seq_HepG2_Human1.62669681
35SOX9_24532713_ChIP-Seq_HFSC_Mouse1.59368095
36* SMAD4_21799915_ChIP-Seq_A2780_Human1.58495637
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.57718721
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55318387
39* AHR_22903824_ChIP-Seq_MCF-7_Human1.53815292
40TP53_16413492_ChIP-PET_HCT116_Human1.47900751
41PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.47812180
42ESR1_20079471_ChIP-ChIP_T-47D_Human1.47805887
43TBX20_22080862_ChIP-Seq_HEART_Mouse1.46021856
44TBX20_22328084_ChIP-Seq_HEART_Mouse1.46021856
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.45664833
46REST_21632747_ChIP-Seq_MESCs_Mouse1.45129133
47* ARNT_22903824_ChIP-Seq_MCF-7_Human1.43823391
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.43454641
49WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.42838207
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.42699791
51PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.40866131
52WT1_25993318_ChIP-Seq_PODOCYTE_Human1.37997844
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36402446
54EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36342688
55* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.35855719
56NFIB_24661679_ChIP-Seq_LUNG_Mouse1.35655747
57EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.31649573
58AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30964857
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29190044
60PPAR_26484153_Chip-Seq_NCI-H1993_Human1.27849403
61* SOX2_21211035_ChIP-Seq_LN229_Gbm1.27219302
62FOXO3_23340844_ChIP-Seq_DLD1_Human1.25896042
63TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.25044126
64PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.24895034
65SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.24634298
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24355706
67RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24328568
68THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.23983015
69PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.23561319
70ESR1_21235772_ChIP-Seq_MCF-7_Human1.22364654
71TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22054061
72TP53_18474530_ChIP-ChIP_U2OS_Human1.21605810
73TAF15_26573619_Chip-Seq_HEK293_Human1.20959944
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.20898339
75SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20446015
76* STAT3_23295773_ChIP-Seq_U87_Human1.20267656
77* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18723866
78P300_19829295_ChIP-Seq_ESCs_Human1.18315412
79* AR_19668381_ChIP-Seq_PC3_Human1.18001514
80ZFP281_27345836_Chip-Seq_ESCs_Mouse1.17048530
81RING1B_27294783_Chip-Seq_ESCs_Mouse1.16776041
82KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16608036
83BCAT_22108803_ChIP-Seq_LS180_Human1.14918999
84CTBP1_25329375_ChIP-Seq_LNCAP_Human1.14696271
85* AR_25329375_ChIP-Seq_VCAP_Human1.14016553
86IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13581462
87NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13562083
88SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.13027382
89SALL4_18804426_ChIP-ChIP_XEN_Mouse1.12850387
90ZNF274_21170338_ChIP-Seq_K562_Hela1.12788605
91YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11031179
92CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.10547073
93CTNNB1_20460455_ChIP-Seq_HCT116_Human1.10135967
94KDM2B_26808549_Chip-Seq_K562_Human1.09994897
95LXR_22158963_ChIP-Seq_LIVER_Mouse1.09679521
96RBPJ_22232070_ChIP-Seq_NCS_Mouse1.09445651
97SMAD4_21741376_ChIP-Seq_HESCs_Human1.08779643
98RXR_22108803_ChIP-Seq_LS180_Human1.08719285
99NRF2_20460467_ChIP-Seq_MEFs_Mouse1.08292436
100NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.08292436
101REST_18959480_ChIP-ChIP_MESCs_Mouse1.08008727
102BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07948639
103RING1B_27294783_Chip-Seq_NPCs_Mouse1.07136744
104RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.07033380
105GATA2_21666600_ChIP-Seq_HMVEC_Human1.06955734
106SMAD3_21741376_ChIP-Seq_HESCs_Human1.06940554
107* TCF4_18268006_ChIP-ChIP_LS174T_Human1.06151943
108P300_27058665_Chip-Seq_ZR-75-30cells_Human1.05045686
109* CDX2_20551321_ChIP-Seq_CACO-2_Human1.04643526
110* TCF4_23295773_ChIP-Seq_U87_Human1.03724089
111ISL1_27105846_Chip-Seq_CPCs_Mouse1.03710710
112ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02276658
113WT1_19549856_ChIP-ChIP_CCG9911_Human1.02131378
114SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02058309
115TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.01635880
116TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00060885
117TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.99262638
118MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.98764940
119BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.98595670
120ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.98166039
121CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.98043427
122CJUN_26792858_Chip-Seq_BT549_Human0.97789725
123ESR2_21235772_ChIP-Seq_MCF-7_Human0.97769177
124ZFP57_27257070_Chip-Seq_ESCs_Mouse0.97744167
125DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.97285602
126POU3F2_20337985_ChIP-ChIP_501MEL_Human0.96545340
127TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95953157
128RUNX2_22187159_ChIP-Seq_PCA_Human0.94127096
129CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.94094196
130STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.94004800
131TP53_23651856_ChIP-Seq_MEFs_Mouse0.93891747
132ZFP281_18757296_ChIP-ChIP_E14_Mouse0.91837280
133ERG_21242973_ChIP-ChIP_JURKAT_Human0.89897726
134MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89667477

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.58484159
2MP0004270_analgesia2.83366612
3MP0003635_abnormal_synaptic_transmissio2.80589114
4MP0009780_abnormal_chondrocyte_physiolo2.74196953
5MP0003880_abnormal_central_pattern2.47396323
6MP0005409_darkened_coat_color2.47198097
7MP0004272_abnormal_basement_membrane2.38253904
8MP0000751_myopathy2.37591880
9MP0003566_abnormal_cell_adhesion2.34713078
10MP0002837_dystrophic_cardiac_calcinosis2.20281027
11MP0002063_abnormal_learning/memory/cond2.19386219
12MP0004084_abnormal_cardiac_muscle2.13660728
13MP0005623_abnormal_meninges_morphology2.12625851
14MP0009745_abnormal_behavioral_response2.10032170
15MP0010368_abnormal_lymphatic_system2.09812942
16MP0004215_abnormal_myocardial_fiber2.00716664
17MP0002734_abnormal_mechanical_nocicepti1.97675649
18MP0008438_abnormal_cutaneous_collagen1.96306491
19MP0010352_gastrointestinal_tract_polyps1.88205679
20MP0009046_muscle_twitch1.85075628
21MP0001968_abnormal_touch/_nociception1.83449709
22MP0001879_abnormal_lymphatic_vessel1.82856852
23MP0005670_abnormal_white_adipose1.80891744
24MP0004858_abnormal_nervous_system1.78606474
25MP0002064_seizures1.78050433
26MP0004484_altered_response_of1.74824488
27MP0002822_catalepsy1.72646999
28MP0000013_abnormal_adipose_tissue1.72071069
29MP0002572_abnormal_emotion/affect_behav1.69354483
30MP0005167_abnormal_blood-brain_barrier1.68592358
31MP0003690_abnormal_glial_cell1.63403013
32MP0001486_abnormal_startle_reflex1.60609870
33MP0002735_abnormal_chemical_nociception1.59689828
34MP0006138_congestive_heart_failure1.53204872
35MP0004085_abnormal_heartbeat1.52756690
36MP0005503_abnormal_tendon_morphology1.50631318
37MP0002272_abnormal_nervous_system1.49678531
38MP0003868_abnormal_feces_composition1.49230335
39MP0004036_abnormal_muscle_relaxation1.48837796
40MP0000778_abnormal_nervous_system1.47051173
41MP0002972_abnormal_cardiac_muscle1.46625947
42MP0002909_abnormal_adrenal_gland1.44836246
43MP0003122_maternal_imprinting1.43994253
44MP0005023_abnormal_wound_healing1.41996854
45MP0005423_abnormal_somatic_nervous1.41320682
46MP0005620_abnormal_muscle_contractility1.40596530
47MP0005275_abnormal_skin_tensile1.39547162
48MP0001501_abnormal_sleep_pattern1.39269818
49MP0001915_intracranial_hemorrhage1.39021193
50MP0005666_abnormal_adipose_tissue1.38392085
51MP0002877_abnormal_melanocyte_morpholog1.32953596
52MP0005375_adipose_tissue_phenotype1.32859969
53MP0001958_emphysema1.30285181
54MP0005330_cardiomyopathy1.29565525
55MP0008775_abnormal_heart_ventricle1.29395459
56MP0008569_lethality_at_weaning1.29328836
57MP0004145_abnormal_muscle_electrophysio1.28874080
58MP0004130_abnormal_muscle_cell1.28307260
59MP0000767_abnormal_smooth_muscle1.28271363
60MP0001177_atelectasis1.26064711
61MP0002733_abnormal_thermal_nociception1.25893653
62MP0003045_fibrosis1.24962988
63MP0000749_muscle_degeneration1.24188135
64MP0000569_abnormal_digit_pigmentation1.23897174
65MP0001440_abnormal_grooming_behavior1.23386351
66MP0002736_abnormal_nociception_after1.22326217
67MP0002067_abnormal_sensory_capabilities1.20371017
68MP0001970_abnormal_pain_threshold1.19588049
69MP0003279_aneurysm1.18989496
70MP0004811_abnormal_neuron_physiology1.18606551
71MP0004087_abnormal_muscle_fiber1.18403672
72MP0005386_behavior/neurological_phenoty1.17933234
73MP0004924_abnormal_behavior1.17933234
74MP0002184_abnormal_innervation1.17617794
75MP0003705_abnormal_hypodermis_morpholog1.16772425
76MP0000733_abnormal_muscle_development1.16509163
77MP0005076_abnormal_cell_differentiation1.14506495
78MP0002108_abnormal_muscle_morphology1.13397663
79MP0005171_absent_coat_pigmentation1.11784893
80MP0000920_abnormal_myelination1.11648128
81MP0003137_abnormal_impulse_conducting1.10877341
82MP0003828_pulmonary_edema1.10637897
83MP0001544_abnormal_cardiovascular_syste1.07986485
84MP0005385_cardiovascular_system_phenoty1.07986485
85MP0003941_abnormal_skin_development1.07844868
86MP0005257_abnormal_intraocular_pressure1.07011301
87MP0003633_abnormal_nervous_system1.06971487
88MP0003283_abnormal_digestive_organ1.06905017
89MP0003787_abnormal_imprinting1.06837332
90MP0002089_abnormal_postnatal_growth/wei1.05491106
91MP0002896_abnormal_bone_mineralization1.05038644
92MP0003634_abnormal_glial_cell1.03470021
93MP0001849_ear_inflammation1.02905002
94MP0002557_abnormal_social/conspecific_i1.01093097
95MP0004885_abnormal_endolymph1.00864667
96MP0001299_abnormal_eye_distance/0.99898344
97MP0001661_extended_life_span0.98949944
98MP0000955_abnormal_spinal_cord0.98469818
99MP0000462_abnormal_digestive_system0.97162157
100MP0010630_abnormal_cardiac_muscle0.96932346
101MP0002269_muscular_atrophy0.96459830
102MP0000747_muscle_weakness0.95790551
103MP0010234_abnormal_vibrissa_follicle0.95575456
104MP0002295_abnormal_pulmonary_circulatio0.95120759
105MP0004185_abnormal_adipocyte_glucose0.95118932
106MP0004233_abnormal_muscle_weight0.95049911
107MP0002128_abnormal_blood_circulation0.93613890
108MP0003091_abnormal_cell_migration0.93573988
109MP0005187_abnormal_penis_morphology0.92884268
110MP0003632_abnormal_nervous_system0.92679922
111MP0003329_amyloid_beta_deposits0.92624339
112MP0003879_abnormal_hair_cell0.90921558
113MP0008961_abnormal_basal_metabolism0.90788060
114MP0005165_increased_susceptibility_to0.89014115
115MP0000537_abnormal_urethra_morphology0.88532301
116MP0000003_abnormal_adipose_tissue0.87608729
117MP0002882_abnormal_neuron_morphology0.87576395
118MP0000534_abnormal_ureter_morphology0.87042313
119MP0002060_abnormal_skin_morphology0.86884083
120MP0002971_abnormal_brown_adipose0.86855001
121MP0003631_nervous_system_phenotype0.86741192
122MP0002925_abnormal_cardiovascular_devel0.86449991
123MP0003385_abnormal_body_wall0.86297185
124MP0002133_abnormal_respiratory_system0.85940779
125MP0005388_respiratory_system_phenotype0.85940779
126MP0004782_abnormal_surfactant_physiolog0.85220949
127MP0003950_abnormal_plasma_membrane0.83881522
128MP0001188_hyperpigmentation0.83413975
129MP0003115_abnormal_respiratory_system0.82570735
130MP0002066_abnormal_motor_capabilities/c0.81971084
131MP0001348_abnormal_lacrimal_gland0.81690988
132MP0005369_muscle_phenotype0.81030408
133MP0006276_abnormal_autonomic_nervous0.79949838
134MP0002009_preneoplasia0.77899566
135MP0000566_synostosis0.77467388
136MP0005595_abnormal_vascular_smooth0.77463076
137MP0002127_abnormal_cardiovascular_syste0.77405706
138MP0000759_abnormal_skeletal_muscle0.74940461
139MP0001614_abnormal_blood_vessel0.74789224
140MP0000762_abnormal_tongue_morphology0.74058534
141MP0009384_cardiac_valve_regurgitation0.73054769

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)3.95370836
2Myokymia (HP:0002411)3.69295927
3Focal seizures (HP:0007359)3.58642033
4Action tremor (HP:0002345)3.34198810
5Sudden death (HP:0001699)3.33981923
6Atrial fibrillation (HP:0005110)2.90590549
7Prolonged QT interval (HP:0001657)2.85092799
8Visual hallucinations (HP:0002367)2.81040092
9Primary atrial arrhythmia (HP:0001692)2.79130395
10Progressive cerebellar ataxia (HP:0002073)2.71596943
11Atonic seizures (HP:0010819)2.69655968
12Premature rupture of membranes (HP:0001788)2.66927771
13Aortic dissection (HP:0002647)2.65983943
14Supraventricular arrhythmia (HP:0005115)2.61148263
15Broad metatarsal (HP:0001783)2.58082378
16Supraventricular tachycardia (HP:0004755)2.55213702
17Epileptic encephalopathy (HP:0200134)2.53672396
18Termporal pattern (HP:0011008)2.51466357
19Insidious onset (HP:0003587)2.51466357
20Atrophic scars (HP:0001075)2.46928875
21Lower limb amyotrophy (HP:0007210)2.45914004
22Vertebral arch anomaly (HP:0008438)2.45203872
23Syncope (HP:0001279)2.44904480
24Cerebral aneurysm (HP:0004944)2.42387196
25Neurofibrillary tangles (HP:0002185)2.41400520
26Wormian bones (HP:0002645)2.38679808
27Hyporeflexia of lower limbs (HP:0002600)2.33659967
28Genetic anticipation (HP:0003743)2.32230333
29Febrile seizures (HP:0002373)2.32145485
30Shallow orbits (HP:0000586)2.30826274
31Abnormality of the calf musculature (HP:0001430)2.30071174
32Broad-based gait (HP:0002136)2.29390941
33Mitral valve prolapse (HP:0001634)2.28477025
34Bundle branch block (HP:0011710)2.28203235
35Overgrowth (HP:0001548)2.27269225
36Ventricular fibrillation (HP:0001663)2.26982269
37Difficulty running (HP:0009046)2.25232639
38Cerebral inclusion bodies (HP:0100314)2.24704960
39Subacute progressive viral hepatitis (HP:0006572)2.23702523
40Abnormal EKG (HP:0003115)2.23587285
41Osteolytic defects of the phalanges of the hand (HP:0009771)2.22857488
42Osteolytic defects of the hand bones (HP:0009699)2.22857488
43Dysmetric saccades (HP:0000641)2.22650868
44Increased variability in muscle fiber diameter (HP:0003557)2.22440628
45Hypoplasia of the iris (HP:0007676)2.21984529
46Bradycardia (HP:0001662)2.20025796
47Poor eye contact (HP:0000817)2.18903119
48Obstructive sleep apnea (HP:0002870)2.15944348
49Mitral stenosis (HP:0001718)2.14697800
50Myotonia (HP:0002486)2.14017422
51Urinary bladder sphincter dysfunction (HP:0002839)2.13787969
52Hemiplegia (HP:0002301)2.12531126
53Papilledema (HP:0001085)2.12196981
54Increased connective tissue (HP:0009025)2.12121611
55Deep venous thrombosis (HP:0002625)2.11344534
56Absence seizures (HP:0002121)2.10617567
57Hyperacusis (HP:0010780)2.08928140
58Right ventricular cardiomyopathy (HP:0011663)2.08199801
59Ankle clonus (HP:0011448)2.06805832
60Amblyopia (HP:0000646)2.06026996
61Aneurysm (HP:0002617)2.05751191
62Alacrima (HP:0000522)2.04350517
63Generalized tonic-clonic seizures (HP:0002069)2.04244622
64Abnormal social behavior (HP:0012433)2.03569836
65Impaired social interactions (HP:0000735)2.03569836
66Aqueductal stenosis (HP:0002410)2.03196663
67Neonatal short-limb short stature (HP:0008921)2.00772522
68Impaired vibration sensation in the lower limbs (HP:0002166)2.00745818
69Dysdiadochokinesis (HP:0002075)2.00639572
70Aplasia involving bones of the extremities (HP:0009825)2.00197380
71Aplasia involving bones of the upper limbs (HP:0009823)2.00197380
72Aplasia of the phalanges of the hand (HP:0009802)2.00197380
73Macroorchidism (HP:0000053)2.00186039
74Ulnar bowing (HP:0003031)2.00040800
75Enlarged penis (HP:0000040)1.99904435
76Hypoventilation (HP:0002791)1.99662945
77Broad face (HP:0000283)1.98993502
78Bronchomalacia (HP:0002780)1.98476959
79Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.97127830
80Muscle fiber splitting (HP:0003555)1.95845311
81Complement deficiency (HP:0004431)1.95743053
82Limited hip movement (HP:0008800)1.94802891
83Scanning speech (HP:0002168)1.94756749
84Fragile skin (HP:0001030)1.94669572
85Hyperventilation (HP:0002883)1.94585773
86Aortic aneurysm (HP:0004942)1.93861261
87Calf muscle hypertrophy (HP:0008981)1.93703490
88Mutism (HP:0002300)1.92679482
89Depression (HP:0000716)1.92251801
90Flat acetabular roof (HP:0003180)1.91413220
91Vascular tortuosity (HP:0004948)1.91232747
92Lymphangioma (HP:0100764)1.91022122
93Gaze-evoked nystagmus (HP:0000640)1.89901937
94Supranuclear gaze palsy (HP:0000605)1.88955014
95Drooling (HP:0002307)1.88698525
96Excessive salivation (HP:0003781)1.88698525
97Truncal ataxia (HP:0002078)1.86611506
98Hammertoe (HP:0001765)1.86035656
99Ventricular arrhythmia (HP:0004308)1.85714379
100Anxiety (HP:0000739)1.84768741
101Urinary urgency (HP:0000012)1.84639189
102Lower limb muscle weakness (HP:0007340)1.84200572
103Protrusio acetabuli (HP:0003179)1.83691107
104Buphthalmos (HP:0000557)1.83192900
105Abnormality of skeletal muscle fiber size (HP:0012084)1.82701417
106Mildly elevated creatine phosphokinase (HP:0008180)1.82698418
107Heterotopia (HP:0002282)1.82240517
108Torticollis (HP:0000473)1.81421928
109Pheochromocytoma (HP:0002666)1.79959079
110Abnormality of carpal bone ossification (HP:0006257)1.79555049
111Exercise-induced myalgia (HP:0003738)1.79033101
112Short nail (HP:0001799)1.78312103
113Insomnia (HP:0100785)1.77389217
114Spinal rigidity (HP:0003306)1.76949260
115Dialeptic seizures (HP:0011146)1.76486697
116Arterial tortuosity (HP:0005116)1.76303147
117Abnormal eating behavior (HP:0100738)1.76173381
118Mitral regurgitation (HP:0001653)1.74556166
119Wide anterior fontanel (HP:0000260)1.74047290
120Renovascular hypertension (HP:0100817)1.73905878
121Dysmetria (HP:0001310)1.73831495
122Exercise-induced muscle cramps (HP:0003710)1.73683808
123Postural instability (HP:0002172)1.73047850
124Impaired pain sensation (HP:0007328)1.72453169
125Abnormality of pain sensation (HP:0010832)1.72453169
126Bladder diverticulum (HP:0000015)1.71789749
127Striae distensae (HP:0001065)1.71590065
128Abnormal ossification of hand bones (HP:0005921)1.71333756
129Asymmetry of the thorax (HP:0001555)1.70962514
130Short chin (HP:0000331)1.70628367
131Abnormality of complement system (HP:0005339)1.70521617
132Distal upper limb amyotrophy (HP:0007149)1.70296761
133Upper limb amyotrophy (HP:0009129)1.70296761
134Dilatation of the ascending aorta (HP:0005111)1.70282461
135Ankyloglossia (HP:0010296)1.70066781
136Blue irides (HP:0000635)1.69715823
137Decreased lacrimation (HP:0000633)1.67880311
138Lipoatrophy (HP:0100578)1.67876960
139Interstitial pulmonary disease (HP:0006530)1.67693442
140Distal lower limb amyotrophy (HP:0008944)1.66935373
141Hemiparesis (HP:0001269)1.66547083
142Muscle hypertrophy of the lower extremities (HP:0008968)1.66361250
143Atrioventricular block (HP:0001678)1.65566725
144Rapidly progressive (HP:0003678)1.65348627
145Exotropia (HP:0000577)1.65026817
146Hemangiomatosis (HP:0007461)1.64359338
147EMG: myopathic abnormalities (HP:0003458)1.64052223
148Turricephaly (HP:0000262)1.63964710
149Ventricular tachycardia (HP:0004756)1.63199359
150Hemorrhage of the eye (HP:0011885)1.61535053
151Arnold-Chiari malformation (HP:0002308)1.60915935
152Visceral angiomatosis (HP:0100761)1.60910527
153Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.59672281
154Abnormality of the distal phalanx of the thumb (HP:0009617)1.59354028
155Difficulty climbing stairs (HP:0003551)1.56475636
156Advanced eruption of teeth (HP:0006288)1.56148503
157Abnormality of the lower motor neuron (HP:0002366)1.53003570
158Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.52790422
159Hypopigmentation of the fundus (HP:0007894)1.52396849
160Dislocated radial head (HP:0003083)1.52013600
161Spinal cord compression (HP:0002176)1.51481452
162Decreased motor nerve conduction velocity (HP:0003431)1.51350862

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.32748583
2MARK12.72369757
3EPHA42.66392023
4MAP3K92.37460043
5MAP3K42.34782535
6TIE12.32351280
7MINK12.22595183
8ICK2.20150029
9CDK122.16722455
10FGFR42.05340817
11PRKD32.02369298
12MST1R1.98605272
13EEF2K1.98599478
14MET1.93504623
15LMTK21.93195846
16RIPK11.84960909
17NTRK11.75725488
18LATS11.69788436
19PAK61.69640313
20DAPK21.69156997
21LATS21.53164242
22MAP2K71.51633434
23INSRR1.49776878
24PTK2B1.48718172
25PHKG21.48411433
26PHKG11.48411433
27NTRK21.47871568
28DMPK1.47325328
29PDGFRA1.41919349
30CAMK1G1.40351129
31FER1.39496630
32PLK21.39318580
33KSR21.34712470
34CAMKK11.34258045
35PAK31.32654032
36FRK1.32474347
37PRKCH1.29134042
38MAP2K41.27228919
39SGK21.21731969
40KDR1.21287190
41MAP3K21.20771679
42CDK51.17586515
43KSR11.15915090
44EPHB21.14637970
45STK381.13780095
46MTOR1.11556795
47MYLK1.11217007
48SGK4941.11006318
49SGK2231.11006318
50FGFR21.10926758
51SGK31.10730254
52RET1.10698777
53MAPK131.09300959
54TTN1.05257791
55TRPM71.04941491
56AKT31.04220062
57CASK1.03967273
58NEK91.00566045
59CAMK1D0.99265021
60WNK10.98110198
61MAP3K120.96088141
62EPHA20.93589815
63UHMK10.92349672
64DDR20.91355720
65GRK50.90574914
66PRPF4B0.90404024
67TYRO30.89171071
68ERBB30.87270088
69CDC42BPA0.87022144
70OBSCN0.86663142
71MARK20.86131085
72PAK20.85948287
73EPHA30.83541504
74TGFBR20.82373600
75PIK3CA0.82247471
76CAMK2A0.79813334
77MAP3K60.79092285
78PRKCE0.77859261
79ROCK10.77735939
80SIK20.75783309
81TRIB30.74860617
82BRD40.74750132
83CAMK10.74709538
84PDK20.74682478
85SGK10.72391048
86CAMKK20.71579479
87MAP2K10.70203469
88STK110.69902109
89DAPK10.69372603
90* MAPK100.67740303
91PDGFRB0.65404220
92PKN20.64968482
93PRKCG0.64794826
94PRKAA20.64500270
95NEK10.63272010
96PDK30.62579792
97PDK40.62579792
98BCR0.62208628
99SIK10.61525177
100PRKD10.61183041
101STK38L0.60091153
102PTK20.59168962
103MAPK70.58878603
104RPS6KA20.58591325
105MELK0.58501493
106TNIK0.57963356
107FGFR10.57680872
108STK240.57526987
109NEK60.55630196
110PNCK0.54366823
111ROCK20.53970898
112MAP3K70.53605594
113STK390.53164945
114FGFR30.53076347
115PRKAA10.52847560
116JAK10.52645668
117MAPK120.51141662
118CAMK2D0.51137263
119PDPK10.51035256
120WNK40.50944535
121CAMK40.50598361
122NLK0.50138494
123ERBB40.49437091
124MAPK110.48728393
125MAP3K130.48665843
126CSNK1G20.48383984
127TAOK10.47783881
128CAMK2B0.46752767
129SCYL20.46375327
130CDK140.44616338
131SMG10.43586876
132FYN0.43480780
133ALK0.42965749
134* RPS6KA30.42760873
135MAP3K100.41948494
136CDK60.39999819

Predicted pathways (KEGG)

RankGene SetZ-score
1Circadian entrainment_Homo sapiens_hsa047132.17670601
2Nicotine addiction_Homo sapiens_hsa050332.14308362
3Long-term potentiation_Homo sapiens_hsa047202.04561017
4Olfactory transduction_Homo sapiens_hsa047401.97033477
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.85885949
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.85282243
7Glutamatergic synapse_Homo sapiens_hsa047241.83985636
8Salivary secretion_Homo sapiens_hsa049701.82534429
9GABAergic synapse_Homo sapiens_hsa047271.80734555
10Dilated cardiomyopathy_Homo sapiens_hsa054141.80197348
11Synaptic vesicle cycle_Homo sapiens_hsa047211.79782975
12Morphine addiction_Homo sapiens_hsa050321.79427136
13Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.75416965
14Renin secretion_Homo sapiens_hsa049241.75083679
15Amphetamine addiction_Homo sapiens_hsa050311.73453887
16Gastric acid secretion_Homo sapiens_hsa049711.72807059
17Dopaminergic synapse_Homo sapiens_hsa047281.66221910
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.65568722
19Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.63554835
20Insulin secretion_Homo sapiens_hsa049111.60523505
21Cholinergic synapse_Homo sapiens_hsa047251.59843634
22Oxytocin signaling pathway_Homo sapiens_hsa049211.51666453
23Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.46698019
24Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.44927341
25Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.43582487
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.41745170
27Axon guidance_Homo sapiens_hsa043601.40689933
28Taste transduction_Homo sapiens_hsa047421.37854629
29Gap junction_Homo sapiens_hsa045401.36888345
30cGMP-PKG signaling pathway_Homo sapiens_hsa040221.33559905
31GnRH signaling pathway_Homo sapiens_hsa049121.33160968
32Calcium signaling pathway_Homo sapiens_hsa040201.32549592
33Long-term depression_Homo sapiens_hsa047301.32538426
34cAMP signaling pathway_Homo sapiens_hsa040241.28173829
35Estrogen signaling pathway_Homo sapiens_hsa049151.25941674
36Glioma_Homo sapiens_hsa052141.23556095
37Type II diabetes mellitus_Homo sapiens_hsa049301.23408350
38Melanogenesis_Homo sapiens_hsa049161.20943122
39Cocaine addiction_Homo sapiens_hsa050301.20726465
40Complement and coagulation cascades_Homo sapiens_hsa046101.19707199
41Serotonergic synapse_Homo sapiens_hsa047261.19238671
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.18924946
43Focal adhesion_Homo sapiens_hsa045101.17434496
44Vascular smooth muscle contraction_Homo sapiens_hsa042701.15265150
45Dorso-ventral axis formation_Homo sapiens_hsa043201.14988401
46Prion diseases_Homo sapiens_hsa050201.12369328
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.12308270
48Cardiac muscle contraction_Homo sapiens_hsa042601.11972103
49Vitamin B6 metabolism_Homo sapiens_hsa007501.09335604
50Adherens junction_Homo sapiens_hsa045201.08483566
51ECM-receptor interaction_Homo sapiens_hsa045121.02874871
52Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.02457129
53Phosphatidylinositol signaling system_Homo sapiens_hsa040700.99807936
54Rap1 signaling pathway_Homo sapiens_hsa040150.97471025
55ErbB signaling pathway_Homo sapiens_hsa040120.96273549
56Thyroid hormone synthesis_Homo sapiens_hsa049180.95356310
57Phospholipase D signaling pathway_Homo sapiens_hsa040720.94223467
58Tight junction_Homo sapiens_hsa045300.93400840
59PPAR signaling pathway_Homo sapiens_hsa033200.92685935
60Histidine metabolism_Homo sapiens_hsa003400.92456239
61Chronic myeloid leukemia_Homo sapiens_hsa052200.91706474
62Small cell lung cancer_Homo sapiens_hsa052220.91062443
63Endometrial cancer_Homo sapiens_hsa052130.89553625
64Arginine biosynthesis_Homo sapiens_hsa002200.88722672
65Thyroid hormone signaling pathway_Homo sapiens_hsa049190.88435191
66MicroRNAs in cancer_Homo sapiens_hsa052060.87343701
67Lysine degradation_Homo sapiens_hsa003100.82724276
68Circadian rhythm_Homo sapiens_hsa047100.82537060
69Leukocyte transendothelial migration_Homo sapiens_hsa046700.79291729
70Pancreatic secretion_Homo sapiens_hsa049720.78555017
71Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78448107
72Thyroid cancer_Homo sapiens_hsa052160.78296544
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78182263
74Proteoglycans in cancer_Homo sapiens_hsa052050.78143922
75Choline metabolism in cancer_Homo sapiens_hsa052310.76393093
76Glucagon signaling pathway_Homo sapiens_hsa049220.75686540
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75040983
78Ras signaling pathway_Homo sapiens_hsa040140.74875083
79Pancreatic cancer_Homo sapiens_hsa052120.74095230
80MAPK signaling pathway_Homo sapiens_hsa040100.73288870
81Renal cell carcinoma_Homo sapiens_hsa052110.72290447
82Non-small cell lung cancer_Homo sapiens_hsa052230.70950119
83Insulin signaling pathway_Homo sapiens_hsa049100.70625203
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69733713
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.69732094
86VEGF signaling pathway_Homo sapiens_hsa043700.68396771
87Hippo signaling pathway_Homo sapiens_hsa043900.68283718
88Amoebiasis_Homo sapiens_hsa051460.67666191
89AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67413968
90Phenylalanine metabolism_Homo sapiens_hsa003600.67310747
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.66996084
92Ovarian steroidogenesis_Homo sapiens_hsa049130.66978813
93Wnt signaling pathway_Homo sapiens_hsa043100.66906312
94Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66737874
95PI3K-Akt signaling pathway_Homo sapiens_hsa041510.66483178
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.65402922
97Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.65248407
98mTOR signaling pathway_Homo sapiens_hsa041500.64852815
99Platelet activation_Homo sapiens_hsa046110.63404490
100Oocyte meiosis_Homo sapiens_hsa041140.62345177
101Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.60385720
102Bile secretion_Homo sapiens_hsa049760.58516134
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58267581
104Endocytosis_Homo sapiens_hsa041440.56144129
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.54953102
106Protein digestion and absorption_Homo sapiens_hsa049740.54883924
107Colorectal cancer_Homo sapiens_hsa052100.52988836
108Insulin resistance_Homo sapiens_hsa049310.52862152
109Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52495225
110Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52223138
111Fatty acid biosynthesis_Homo sapiens_hsa000610.51889192
112Melanoma_Homo sapiens_hsa052180.50650966
113AMPK signaling pathway_Homo sapiens_hsa041520.50603931
114Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50282276
115HIF-1 signaling pathway_Homo sapiens_hsa040660.49533533
116Central carbon metabolism in cancer_Homo sapiens_hsa052300.49219086
117Inositol phosphate metabolism_Homo sapiens_hsa005620.46671392
118Viral myocarditis_Homo sapiens_hsa054160.45121879
119TGF-beta signaling pathway_Homo sapiens_hsa043500.44297228
120Hedgehog signaling pathway_Homo sapiens_hsa043400.43563394

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