SPTA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. This gene is one member of a family of alpha-spectrin genes. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms weaker tetramer interactions than non-erythrocytic alpha spectrin, which may increase the plasma membrane elasticity and deformability of red blood cells. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1heme metabolic process (GO:0042168)9.80320463
2* porphyrin-containing compound metabolic process (GO:0006778)9.75687448
3hemoglobin metabolic process (GO:0020027)9.62462313
4response to methylmercury (GO:0051597)8.08212792
5erythrocyte development (GO:0048821)7.72045566
6response to insecticide (GO:0017085)6.75050878
7response to lead ion (GO:0010288)6.47809175
8* tetrapyrrole metabolic process (GO:0033013)6.20493050
9pigment biosynthetic process (GO:0046148)5.91784688
10negative regulation of erythrocyte differentiation (GO:0045647)5.69043390
11erythrocyte differentiation (GO:0030218)5.68263681
12regulation of response to osmotic stress (GO:0047484)5.22352462
13myeloid cell development (GO:0061515)5.04845404
14DNA topological change (GO:0006265)4.82587869
15pigment metabolic process (GO:0042440)4.80179418
16mitotic sister chromatid segregation (GO:0000070)4.79580367
17response to arsenic-containing substance (GO:0046685)4.74702616
18one-carbon compound transport (GO:0019755)4.59263933
19regulation of RNA export from nucleus (GO:0046831)4.57426690
20iron ion import (GO:0097286)4.56909381
21bicarbonate transport (GO:0015701)4.54125908
22sister chromatid segregation (GO:0000819)4.52463786
23glycine transport (GO:0015816)4.39661584
24very-low-density lipoprotein particle assembly (GO:0034379)4.28279496
25microtubule depolymerization (GO:0007019)4.25829298
26mitotic chromosome condensation (GO:0007076)4.24507384
27regulation of erythrocyte differentiation (GO:0045646)4.23389573
28regulation of DNA endoreduplication (GO:0032875)4.14371919
29protein localization to chromosome, centromeric region (GO:0071459)3.98618716
30regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.93936496
31chromatin assembly (GO:0031497)3.88644570
32DNA replication-dependent nucleosome assembly (GO:0006335)3.87501945
33DNA replication-dependent nucleosome organization (GO:0034723)3.87501945
34nucleosome assembly (GO:0006334)3.83958398
35kinetochore organization (GO:0051383)3.81936085
36positive regulation of mitotic sister chromatid separation (GO:1901970)3.79674764
37positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.79674764
38positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.79674764
39positive regulation of chromosome segregation (GO:0051984)3.76483611
40negative regulation of viral entry into host cell (GO:0046597)3.75416720
41regulation of nucleobase-containing compound transport (GO:0032239)3.73147040
42gas transport (GO:0015669)3.71931153
43DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.71704722
44N-terminal protein amino acid acetylation (GO:0006474)3.70004792
45protein localization to kinetochore (GO:0034501)3.67553836
46cellular response to arsenic-containing substance (GO:0071243)3.67059799
47L-alpha-amino acid transmembrane transport (GO:1902475)3.63130540
48attachment of spindle microtubules to kinetochore (GO:0008608)3.59450922
49regulation of histone H3-K9 methylation (GO:0051570)3.56710305
50positive regulation of megakaryocyte differentiation (GO:0045654)3.56428204
51hematopoietic stem cell differentiation (GO:0060218)3.48704605
52DNA replication initiation (GO:0006270)3.42425708
53platelet formation (GO:0030220)3.42338544
54positive regulation of granulocyte differentiation (GO:0030854)3.42197401
55nucleosome organization (GO:0034728)3.41724903
56regulation of cytokine secretion involved in immune response (GO:0002739)3.38685191
57mucosal immune response (GO:0002385)3.35594249
58DNA unwinding involved in DNA replication (GO:0006268)3.35507134
59meiotic chromosome segregation (GO:0045132)3.35211411
60embryonic hemopoiesis (GO:0035162)3.32757316
61DNA damage response, signal transduction resulting in transcription (GO:0042772)3.31976149
62heme transport (GO:0015886)3.27906674
63positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.27850406
64protein-DNA complex assembly (GO:0065004)3.24797685
65DNA replication checkpoint (GO:0000076)3.23008346
66chromatin assembly or disassembly (GO:0006333)3.21492609
67regulation of centriole replication (GO:0046599)3.20380889
68plasma lipoprotein particle assembly (GO:0034377)3.16073958
69nuclear pore organization (GO:0006999)3.15423880
70positive regulation of erythrocyte differentiation (GO:0045648)3.13092646
71hydrogen peroxide catabolic process (GO:0042744)3.12996478
72positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.06563289
73organ or tissue specific immune response (GO:0002251)3.06024544
74nuclear pore complex assembly (GO:0051292)3.05964684
75granulocyte differentiation (GO:0030851)3.05841818
76* cofactor biosynthetic process (GO:0051188)3.00174263
77cellular response to thyroid hormone stimulus (GO:0097067)3.00157238
78protoporphyrinogen IX metabolic process (GO:0046501)20.9677642
79protein-DNA complex subunit organization (GO:0071824)2.98905278
80kinetochore assembly (GO:0051382)2.96410700
81antibacterial humoral response (GO:0019731)2.95081888
82monoubiquitinated protein deubiquitination (GO:0035520)2.94760394
83water-soluble vitamin biosynthetic process (GO:0042364)2.90478369
84chromosome condensation (GO:0030261)2.88197843
85iron ion homeostasis (GO:0055072)2.87648495
86DNA strand elongation involved in DNA replication (GO:0006271)2.85232415
87CENP-A containing nucleosome assembly (GO:0034080)2.83780360
88definitive hemopoiesis (GO:0060216)2.82907993
89cytoskeletal anchoring at plasma membrane (GO:0007016)2.82719559
90regulation of centrosome cycle (GO:0046605)2.81782778
91regulation of viral entry into host cell (GO:0046596)2.80463721
92import into cell (GO:0098657)2.79393465
93regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.79384405
94mitotic nuclear envelope disassembly (GO:0007077)2.79327854
95regulation of exit from mitosis (GO:0007096)2.78892069
96DNA strand elongation (GO:0022616)2.75263774
97* hemopoiesis (GO:0030097)2.75222313
98positive regulation of bone remodeling (GO:0046852)2.74423172
99positive regulation of bone resorption (GO:0045780)2.74423172
100defense response to fungus (GO:0050832)2.74080818
101chromatin remodeling at centromere (GO:0031055)2.72927897
102mitotic sister chromatid cohesion (GO:0007064)2.71620969
103disruption of cells of other organism (GO:0044364)2.71409693
104killing of cells of other organism (GO:0031640)2.71409693
105antimicrobial humoral response (GO:0019730)2.71083905
106innate immune response in mucosa (GO:0002227)2.70962784
107protein-cofactor linkage (GO:0018065)2.69910952
108telomere maintenance via semi-conservative replication (GO:0032201)2.69719817
109DNA replication-independent nucleosome assembly (GO:0006336)2.69126246
110DNA replication-independent nucleosome organization (GO:0034724)2.69126246
111regulation of centrosome duplication (GO:0010824)2.68875281
112protein-lipid complex assembly (GO:0065005)2.67556225
113megakaryocyte development (GO:0035855)2.66819798
114mitotic metaphase plate congression (GO:0007080)2.65063035
115cellular response to dexamethasone stimulus (GO:0071549)2.64944540
116chromosome segregation (GO:0007059)2.63980078
117microtubule polymerization or depolymerization (GO:0031109)2.63245051
118protein K6-linked ubiquitination (GO:0085020)2.63020524
119nuclear envelope disassembly (GO:0051081)2.62247314
120membrane disassembly (GO:0030397)2.62247314
121protein localization to chromosome (GO:0034502)2.62031228
122negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.59522910
123DNA synthesis involved in DNA repair (GO:0000731)2.56944068
124protein targeting to plasma membrane (GO:0072661)2.56560346
1253-UTR-mediated mRNA stabilization (GO:0070935)2.51836551
126positive regulation of histone methylation (GO:0031062)2.51467337
127response to iron ion (GO:0010039)2.49606181
128DNA ligation (GO:0006266)2.48234078
129centriole assembly (GO:0098534)2.45280345
130positive regulation of gluconeogenesis (GO:0045722)2.43788630
131deoxyribonucleotide biosynthetic process (GO:0009263)2.42688555
132response to dexamethasone (GO:0071548)2.42353462
133protoporphyrinogen IX biosynthetic process (GO:0006782)19.3174060
134heme biosynthetic process (GO:0006783)12.7386115
135* porphyrin-containing compound biosynthetic process (GO:0006779)12.4559187
136oxygen transport (GO:0015671)11.4158414
137* tetrapyrrole biosynthetic process (GO:0033014)11.0866543
138erythrocyte maturation (GO:0043249)10.1662141

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.67320684
2FOXM1_23109430_ChIP-Seq_U2OS_Human6.50612024
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.26251533
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse5.82676072
5GATA1_22025678_ChIP-Seq_K562_Human5.36811028
6GATA1_19941826_ChIP-Seq_K562_Human4.41569136
7E2F4_17652178_ChIP-ChIP_JURKAT_Human4.16600596
8TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse3.95733031
9KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse3.81219600
10GATA1_19941827_ChIP-Seq_MEL_Mouse3.42508153
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.16273455
12SCL_19346495_ChIP-Seq_HPC-7_Human2.70764609
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.58729481
14* GATA2_19941826_ChIP-Seq_K562_Human2.35616375
15GATA1_22383799_ChIP-Seq_G1ME_Mouse2.30358098
16E2F1_21310950_ChIP-Seq_MCF-7_Human2.06511659
17SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.00294568
18AR_21909140_ChIP-Seq_LNCAP_Human1.81259055
19MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.71812985
20ZNF263_19887448_ChIP-Seq_K562_Human1.69323978
21HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.61619880
22MYC_18555785_ChIP-Seq_MESCs_Mouse1.52485553
23TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48935497
24NELFA_20434984_ChIP-Seq_ESCs_Mouse1.46463452
25EGR1_23403033_ChIP-Seq_LIVER_Mouse1.43219616
26TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.41357928
27MYC_22102868_ChIP-Seq_BL_Human1.40439729
28SOX2_16153702_ChIP-ChIP_HESCs_Human1.39042914
29MYC_19030024_ChIP-ChIP_MESCs_Mouse1.35640319
30EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.32958704
31ESR1_15608294_ChIP-ChIP_MCF-7_Human1.26300881
32GATA2_22383799_ChIP-Seq_G1ME_Mouse1.23121597
33EGR1_19374776_ChIP-ChIP_THP-1_Human1.22960311
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.22703278
35NCOR1_26117541_ChIP-Seq_K562_Human1.20825847
36SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.20232450
37VDR_21846776_ChIP-Seq_THP-1_Human1.19530135
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.17979540
39VDR_23849224_ChIP-Seq_CD4+_Human1.16955530
40HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.15498393
41GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15277928
42MYC_18358816_ChIP-ChIP_MESCs_Mouse1.13822657
43CREB1_15753290_ChIP-ChIP_HEK293T_Human1.11436864
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.10951844
45MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.08172224
46MYC_19079543_ChIP-ChIP_MESCs_Mouse1.04701959
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04236057
48CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03783528
49ERG_20887958_ChIP-Seq_HPC-7_Mouse1.01051789
50* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96293460
51BRD4_27068464_Chip-Seq_AML-cells_Mouse0.95967411
52KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.95957473
53HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.95186532
54CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94816346
55EST1_17652178_ChIP-ChIP_JURKAT_Human0.94685498
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.94292891
57BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93782206
58KDM5A_27292631_Chip-Seq_BREAST_Human0.93254580
59KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.92824508
60ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.92625243
61STAT3_1855785_ChIP-Seq_MESCs_Mouse0.91893348
62LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.90677947
63ELF1_17652178_ChIP-ChIP_JURKAT_Human0.90197018
64GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.87159759
65PADI4_21655091_ChIP-ChIP_MCF-7_Human0.87058717
66CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.86948627
67PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.86802431
68YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.86708199
69XRN2_22483619_ChIP-Seq_HELA_Human0.86097848
70FOXP3_21729870_ChIP-Seq_TREG_Human0.86043722
71CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.85924076
72IRF1_19129219_ChIP-ChIP_H3396_Human0.85127946
73E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.84996784
74SPI1_23127762_ChIP-Seq_K562_Human0.84587861
75MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.84457604
76E2F1_18555785_ChIP-Seq_MESCs_Mouse0.84378877
77MYCN_18555785_ChIP-Seq_MESCs_Mouse0.84205930
78TFEB_21752829_ChIP-Seq_HELA_Human0.83775511
79MYB_26560356_Chip-Seq_TH1_Human0.83712182
80SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83119075
81NANOG_21062744_ChIP-ChIP_HESCs_Human0.81451972
82MAF_26560356_Chip-Seq_TH1_Human0.81145074
83SALL4_22934838_ChIP-ChIP_CD34+_Human0.80864388
84ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.80704197
85CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.80573995
86ETS1_20019798_ChIP-Seq_JURKAT_Human0.79782672
87SOX2_18555785_ChIP-Seq_MESCs_Mouse0.78555777
88KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.78223824
89CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.77574293
90NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.77505047
91RUNX1_22412390_ChIP-Seq_EML_Mouse0.77456838
92NANOG_18555785_ChIP-Seq_MESCs_Mouse0.77412266
93CIITA_25753668_ChIP-Seq_RAJI_Human0.76711905
94VDR_24763502_ChIP-Seq_THP-1_Human0.76468419
95GATA1_19941827_ChIP-Seq_MEL86_Mouse0.75848368
96ELK1_19687146_ChIP-ChIP_HELA_Human0.75763013
97UTX_26944678_Chip-Seq_JUKART_Human0.75065395
98SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.72387357
99LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.72033492
100FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.71851220
101ETS1_22383799_ChIP-Seq_G1ME_Mouse0.71194835
102MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.70892143
103KLF4_18555785_ChIP-Seq_MESCs_Mouse0.70791539
104CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.70748797
105STAT4_19710469_ChIP-ChIP_TH1__Mouse0.70395606
106MYB_21317192_ChIP-Seq_ERMYB_Mouse0.70393564
107SRF_21415370_ChIP-Seq_HL-1_Mouse0.69234532
108GATA4_21415370_ChIP-Seq_HL-1_Mouse0.69134157
109SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.69071503
110DCP1A_22483619_ChIP-Seq_HELA_Human0.69009707
111NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.68847644
112ZFX_18555785_ChIP-Seq_MESCs_Mouse0.68362595
113SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.68327261
114TCF7_22412390_ChIP-Seq_EML_Mouse0.68200958
115GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.67880573
116TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.67743570
117KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.67542927
118CTCF_27219007_Chip-Seq_ERYTHROID_Human0.67352553
119KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.67337043
120CHD1_26751641_Chip-Seq_LNCaP_Human0.66936845
121SPI1_23547873_ChIP-Seq_NB4_Human0.66392238
122KDM2B_26808549_Chip-Seq_DND41_Human0.66066210
123MYB_26560356_Chip-Seq_TH2_Human0.65192676

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003111_abnormal_nucleus_morphology3.82132646
2MP0005083_abnormal_biliary_tract3.35614538
3MP0010094_abnormal_chromosome_stability2.83245573
4MP0003077_abnormal_cell_cycle2.38838461
5MP0010307_abnormal_tumor_latency2.11588377
6MP0005397_hematopoietic_system_phenotyp2.10253764
7MP0001545_abnormal_hematopoietic_system2.10253764
8MP0003693_abnormal_embryo_hatching2.08026608
9MP0003656_abnormal_erythrocyte_physiolo11.8528487
10MP0004147_increased_porphyrin_level10.9946231
11MP0005636_abnormal_mineral_homeostasis1.92937797
12MP0008057_abnormal_DNA_replication1.88948649
13MP0004957_abnormal_blastocyst_morpholog1.67555295
14MP0008775_abnormal_heart_ventricle1.57604038
15MP0009697_abnormal_copulation1.56105935
16MP0002396_abnormal_hematopoietic_system1.41740984
17MP0008058_abnormal_DNA_repair1.39270339
18MP0000350_abnormal_cell_proliferation1.32063954
19MP0003303_peritoneal_inflammation1.31096493
20MP0003191_abnormal_cellular_cholesterol1.26986555
21MP0006036_abnormal_mitochondrial_physio1.25745591
22MP0008877_abnormal_DNA_methylation1.24388230
23MP0000490_abnormal_crypts_of1.24196554
24MP0002398_abnormal_bone_marrow1.19719427
25MP0005501_abnormal_skin_physiology1.17913410
26MP0005451_abnormal_body_composition1.14628186
27MP0008770_decreased_survivor_rate1.11579286
28MP0001730_embryonic_growth_arrest1.09698005
29MP0000749_muscle_degeneration1.09693407
30MP0004215_abnormal_myocardial_fiber1.09339346
31MP0002877_abnormal_melanocyte_morpholog1.08689578
32MP0005076_abnormal_cell_differentiation1.06608263
33MP0002722_abnormal_immune_system1.05907649
34MP0000313_abnormal_cell_death1.03881949
35MP0008872_abnormal_physiological_respon1.03112759
36MP0009931_abnormal_skin_appearance1.02517725
37MP0000689_abnormal_spleen_morphology1.01310231
38MP0005464_abnormal_platelet_physiology1.00567220
39MP0003186_abnormal_redox_activity0.99647104
40MP0004808_abnormal_hematopoietic_stem0.95298577
41MP0002086_abnormal_extraembryonic_tissu0.94510216
42MP0002019_abnormal_tumor_incidence0.92399650
43MP0010352_gastrointestinal_tract_polyps0.92038215
44MP0005171_absent_coat_pigmentation0.91038487
45MP0001661_extended_life_span0.90754048
46MP0002080_prenatal_lethality0.89709589
47MP0003806_abnormal_nucleotide_metabolis0.87909150
48MP0002429_abnormal_blood_cell0.87792063
49MP0003123_paternal_imprinting0.85164242
50MP0004197_abnormal_fetal_growth/weight/0.85163524
51MP0005380_embryogenesis_phenotype0.84948031
52MP0001672_abnormal_embryogenesis/_devel0.84948031
53MP0001697_abnormal_embryo_size0.84065944
54MP0006054_spinal_hemorrhage0.82874326
55MP0003984_embryonic_growth_retardation0.81688399
56MP0000685_abnormal_immune_system0.81445395
57MP0002088_abnormal_embryonic_growth/wei0.78597939
58MP0008932_abnormal_embryonic_tissue0.76232145
59MP0003705_abnormal_hypodermis_morpholog0.75803913
60MP0009765_abnormal_xenobiotic_induced0.74695691
61MP0008260_abnormal_autophagy0.74427227
62MP0002132_abnormal_respiratory_system0.73718306
63MP0002166_altered_tumor_susceptibility0.72804779
64MP0003172_abnormal_lysosome_physiology0.71677644
65MP0008007_abnormal_cellular_replicative0.70512573
66MP0002837_dystrophic_cardiac_calcinosis0.69304334
67MP0000703_abnormal_thymus_morphology0.68228473
68MP0003121_genomic_imprinting0.66127645
69MP0009333_abnormal_splenocyte_physiolog0.63319081
70MP0003878_abnormal_ear_physiology0.62937106
71MP0005377_hearing/vestibular/ear_phenot0.62937106
72MP0003567_abnormal_fetal_cardiomyocyte0.62453331
73MP0005621_abnormal_cell_physiology0.61647855
74MP0002972_abnormal_cardiac_muscle0.61397401
75MP0000609_abnormal_liver_physiology0.60849742
76MP0003786_premature_aging0.60800359
77MP0005384_cellular_phenotype0.59552066
78MP0003787_abnormal_imprinting0.59442658
79MP0001529_abnormal_vocalization0.59154500
80MP0000266_abnormal_heart_morphology0.58817791
81MP0009672_abnormal_birth_weight0.55445687
82MP0009764_decreased_sensitivity_to0.55308558
83MP0003566_abnormal_cell_adhesion0.54427922
84MP0009763_increased_sensitivity_to0.53551888
85MP0004145_abnormal_muscle_electrophysio0.52591948
86MP0000598_abnormal_liver_morphology0.52221513
87MP0002009_preneoplasia0.52219884
88MP0003045_fibrosis0.52037468
89MP0004084_abnormal_cardiac_muscle0.50786901
90MP0010771_integument_phenotype0.50774990
91MP0009703_decreased_birth_body0.50460038
92MP0004130_abnormal_muscle_cell0.49767955
93MP0000015_abnormal_ear_pigmentation0.49499494
94MP0009053_abnormal_anal_canal0.49009236
95MP0003221_abnormal_cardiomyocyte_apopto0.48203604
96MP0001544_abnormal_cardiovascular_syste0.48004456
97MP0005385_cardiovascular_system_phenoty0.48004456
98MP0000372_irregular_coat_pigmentation0.47585768
99MP0006035_abnormal_mitochondrial_morpho0.47011201
100MP0002405_respiratory_system_inflammati0.46914479
101MP0003890_abnormal_embryonic-extraembry0.46790453
102MP0002332_abnormal_exercise_endurance0.46286441
103MP0004085_abnormal_heartbeat0.46269835
104MP0001929_abnormal_gametogenesis0.46038907
105MP0002085_abnormal_embryonic_tissue0.45550870
106MP0002084_abnormal_developmental_patter0.45458423
107MP0008995_early_reproductive_senescence0.45134300
108MP0003950_abnormal_plasma_membrane0.44783560
109MP0005075_abnormal_melanosome_morpholog0.43681598
110MP0000358_abnormal_cell_content/0.43475751
111MP0002139_abnormal_hepatobiliary_system0.43138364
112MP0003718_maternal_effect0.42978393
113MP0001191_abnormal_skin_condition0.42333069
114MP0010630_abnormal_cardiac_muscle0.41765901
115MP0009643_abnormal_urine_homeostasis0.41701095
116MP0009278_abnormal_bone_marrow0.40934677
117MP0001784_abnormal_fluid_regulation0.40539077
118MP0003646_muscle_fatigue0.39772171
119MP0005647_abnormal_sex_gland0.39654550
120MP0002083_premature_death0.39412528
121MP0003300_gastrointestinal_ulcer0.39397673
122MP0003763_abnormal_thymus_physiology0.39015525
123MP0002006_tumorigenesis0.38672993
124MP0004264_abnormal_extraembryonic_tissu0.38610118
125MP0005025_abnormal_response_to0.38573168
126MP0005266_abnormal_metabolism0.37454410
127MP0004185_abnormal_adipocyte_glucose0.37348197
128MP0002736_abnormal_nociception_after0.37150530
129MP0002095_abnormal_skin_pigmentation0.37079119
130MP0003699_abnormal_female_reproductive0.35857783
131MP0000716_abnormal_immune_system0.35381252
132MP0000747_muscle_weakness0.35330410
133MP0005220_abnormal_exocrine_pancreas0.33865784

Predicted human phenotypes

RankGene SetZ-score
1Acanthocytosis (HP:0001927)9.97632881
2Reticulocytosis (HP:0001923)8.75897762
3Cholelithiasis (HP:0001081)7.45925837
4Diaphragmatic weakness (HP:0009113)6.94252055
5Abnormal gallbladder morphology (HP:0012437)6.70668560
6Abnormal hemoglobin (HP:0011902)6.49829573
7Paralysis (HP:0003470)6.40035183
8Abnormality of reticulocytes (HP:0004312)5.98952360
9Osteomalacia (HP:0002749)5.75615502
10Hypochromic anemia (HP:0001931)5.57534947
11Hyperbilirubinemia (HP:0002904)5.56611441
12Insomnia (HP:0100785)5.25518432
13Microcytic anemia (HP:0001935)4.73366419
14Abnormality of the gallbladder (HP:0005264)4.55284010
15Cutaneous photosensitivity (HP:0000992)4.25206231
16Abnormal gallbladder physiology (HP:0012438)4.08267763
17Cholecystitis (HP:0001082)4.08267763
18Ileus (HP:0002595)3.88931576
19Polycythemia (HP:0001901)3.39852325
20Abnormal number of erythroid precursors (HP:0012131)3.12532172
21Toxemia of pregnancy (HP:0100603)3.12451401
22Birth length less than 3rd percentile (HP:0003561)3.06007294
23Hepatocellular carcinoma (HP:0001402)2.98635222
24Hyponatremia (HP:0002902)2.90206443
25Abnormality of cells of the erythroid lineage (HP:0012130)2.87016865
26Abnormality of sodium homeostasis (HP:0010931)2.65404857
27Nausea (HP:0002018)2.60344131
28Increased serum ferritin (HP:0003281)2.56184459
29Confusion (HP:0001289)2.49288560
30Urticaria (HP:0001025)2.42165493
31Abnormality of iron homeostasis (HP:0011031)2.40077556
32Global brain atrophy (HP:0002283)2.25102654
33Petechiae (HP:0000967)2.18756915
34Abnormality of transition element cation homeostasis (HP:0011030)2.17189842
35Hypoparathyroidism (HP:0000829)2.15844909
36Renal tubular acidosis (HP:0001947)2.10339339
37Short middle phalanx of the 5th finger (HP:0004220)2.04209958
38Generalized hyperpigmentation (HP:0007440)2.03796609
39Orthostatic hypotension (HP:0001278)2.01791716
40Abnormality of the heme biosynthetic pathway (HP:0010472)14.4418821
41* Poikilocytosis (HP:0004447)13.0176955
42Hypochromic microcytic anemia (HP:0004840)11.5305500
43Pathologic fracture (HP:0002756)1.98508604
44Aplasia/Hypoplasia of the earlobes (HP:0009906)1.98001338
45Onycholysis (HP:0001806)1.97903266
46Macrocytic anemia (HP:0001972)1.97686492
47Prolonged bleeding time (HP:0003010)1.94120226
48Peripheral hypomyelination (HP:0007182)1.91586420
49Delusions (HP:0000746)1.88884312
50Chromsome breakage (HP:0040012)1.88279260
51Abnormal hair whorl (HP:0010721)1.86855748
52Pustule (HP:0200039)1.84870049
53Childhood onset (HP:0011463)1.84469499
54Chromosomal breakage induced by crosslinking agents (HP:0003221)1.82676286
55Hypertensive crisis (HP:0100735)1.78664107
56Acute myeloid leukemia (HP:0004808)1.78309176
57Cerebral palsy (HP:0100021)1.77170185
58Autoimmune hemolytic anemia (HP:0001890)1.74778504
59Gastrointestinal infarctions (HP:0005244)1.73829522
60Cafe-au-lait spot (HP:0000957)1.73137269
61Lower limb hyperreflexia (HP:0002395)1.72643343
62High pitched voice (HP:0001620)1.68815923
63Osteomyelitis (HP:0002754)1.65584810
64Nonimmune hydrops fetalis (HP:0001790)1.65435157
65Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.63091257
66Metaphyseal cupping (HP:0003021)1.63024857
67Hypoplasia of the capital femoral epiphysis (HP:0003090)1.61971902
68Abnormal platelet function (HP:0011869)1.61530949
69Impaired platelet aggregation (HP:0003540)1.61530949
70Abnormality of the fingertips (HP:0001211)1.58648240
71Basal cell carcinoma (HP:0002671)1.56688176
72Broad palm (HP:0001169)1.55314625
7311 pairs of ribs (HP:0000878)1.53965166
74Hypoplastic iliac wings (HP:0002866)1.53642074
75Abnormality of chromosome stability (HP:0003220)1.53517194
76Cortical dysplasia (HP:0002539)1.53438756
77Rickets (HP:0002748)1.50998816
78Autoamputation (HP:0001218)1.50497511
79Impulsivity (HP:0100710)1.50225366
80Neoplasm of the liver (HP:0002896)1.50081811
81Abnormality of nail color (HP:0100643)1.48563440
82Pancreatic islet-cell hyperplasia (HP:0004510)1.48196645
83Thyroid carcinoma (HP:0002890)1.46604289
84Duodenal stenosis (HP:0100867)1.46110985
85Small intestinal stenosis (HP:0012848)1.46110985
86Depression (HP:0000716)1.45825758
87Abnormality of homocysteine metabolism (HP:0010919)1.45625573
88Homocystinuria (HP:0002156)1.45625573
89Abnormality of the renal collecting system (HP:0004742)1.44950954
90Abnormality of dental color (HP:0011073)1.44291458
91Prominent nose (HP:0000448)1.44113932
92Lower limb amyotrophy (HP:0007210)1.43311169
93Volvulus (HP:0002580)1.42828139
94Paresthesia (HP:0003401)1.42819944
95Abnormal blistering of the skin (HP:0008066)1.41998550
96Pallor (HP:0000980)1.40733512
97Limb hypertonia (HP:0002509)1.40469966
98Prostate neoplasm (HP:0100787)1.37668690
99Epistaxis (HP:0000421)1.35033919
100Heterotopia (HP:0002282)1.34173241
101Breast hypoplasia (HP:0003187)1.32698347
102Spinal muscular atrophy (HP:0007269)1.29778843
103Hyperthyroidism (HP:0000836)1.29590690
104Bone marrow hypocellularity (HP:0005528)1.29335444
105Hypertriglyceridemia (HP:0002155)1.29261694
106Anhidrosis (HP:0000970)1.27210325
107Truncus arteriosus (HP:0001660)1.26587222
108Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.26203081
109Increased mean platelet volume (HP:0011877)1.25969873
110Thrombophlebitis (HP:0004418)1.25737164
111Multiple enchondromatosis (HP:0005701)1.23547765
112Abnormal platelet volume (HP:0011876)1.23046692
113Hypopigmented skin patches (HP:0001053)1.22189999
114Spontaneous hematomas (HP:0007420)1.21912045
115Splenomegaly (HP:0001744)1.21800094
116Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.20691914
117Absent epiphyses (HP:0010577)1.20691914
118Rectal prolapse (HP:0002035)1.20606096
119Metabolic acidosis (HP:0001942)1.20432575
120Bowel incontinence (HP:0002607)1.20158361
121Myelodysplasia (HP:0002863)1.20062634
122Abnormal delayed hypersensitivity skin test (HP:0002963)1.19497877
123Abnormality of chromosome segregation (HP:0002916)1.18915111
124Sandal gap (HP:0001852)1.18648163
125Thin skin (HP:0000963)1.17907964
126Patellar aplasia (HP:0006443)1.16802323
127Meckel diverticulum (HP:0002245)1.16317492
128Abnormality of the preputium (HP:0100587)1.13001610
129Autoimmune thrombocytopenia (HP:0001973)1.12905708
130Purpura (HP:0000979)1.12892519
131Short 5th finger (HP:0009237)1.12747720
132Duplicated collecting system (HP:0000081)1.11830081
133Abnormality of the duodenum (HP:0002246)1.11419033
134Long clavicles (HP:0000890)1.10864313
135Aplasia/Hypoplasia of the uvula (HP:0010293)1.10237570
136Aplasia/Hypoplasia of the sternum (HP:0006714)1.10150962
137Gastrointestinal dysmotility (HP:0002579)1.09247241
138Ectopic kidney (HP:0000086)1.08792695

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK17.76845022
2PRPF4B4.60752936
3TLK14.32741855
4CDC73.98793906
5STK43.71301615
6CDK123.47448291
7ZAK3.18495152
8BRSK12.43632187
9TAOK22.23000276
10NEK22.21694522
11EEF2K2.05265357
12STK102.03364629
13PIM11.91659815
14VRK11.87654045
15WNK11.84304516
16BUB11.83108639
17DYRK31.73300266
18NEK11.68446865
19NME21.66022494
20SCYL21.65615358
21AURKB1.63773241
22RPS6KA51.60293196
23TTK1.57422220
24TRPM71.56867376
25CHEK21.40157175
26MAP3K81.39735129
27AURKA1.34263267
28WEE11.32356321
29MAPKAPK31.32322313
30BRSK21.26677240
31CDK41.25784838
32MAPK111.24374262
33BRD41.24338645
34PLK11.21691640
35MELK1.15834569
36RIPK41.14046853
37CDK61.13827387
38MAP3K101.11014637
39CHEK11.09370692
40GRK61.05471360
41CDK91.05316236
42MAP3K30.99223293
43RPS6KB20.98665053
44PKN20.97778902
45ATR0.96425348
46ATM0.95651907
47GRK50.86936962
48PBK0.86506854
49PRKAA10.84439479
50SYK0.84363963
51KSR10.84131719
52RPS6KL10.81494265
53RPS6KC10.81494265
54CCNB10.81157901
55MAP3K60.80906123
56CDC42BPA0.79913913
57ERBB20.78664935
58STK30.77751700
59PLK30.77082549
60TAF10.77065781
61HIPK20.72232762
62SRPK10.71370246
63GRK70.71136280
64CAMK1D0.70757859
65JAK20.69453714
66RPS6KA60.68871271
67TGFBR20.67557701
68BRAF0.67490400
69CSNK1D0.65870316
70KSR20.65705796
71MAP3K50.65495780
72CDK20.64021436
73CDK10.59861042
74MST40.59736211
75FLT30.58791717
76EIF2AK20.57869647
77MAP3K110.57760950
78RAF10.56675263
79TRIB30.56185304
80CDK70.55788175
81TEC0.55192090
82CAMK1G0.54588349
83MAP3K10.51315808
84MAPKAPK50.50806436
85BMX0.49590538
86SGK30.47624701
87MAP2K30.47021500
88ICK0.45642053
89DYRK1B0.45216022
90MAPKAPK20.45153624
91DAPK30.44668507
92PLK20.44575515
93STK110.43744544
94SGK10.43556132
95SMG10.43174676
96TTN0.42939155
97TAOK10.42325679
98PRKDC0.41515472
99MAP2K20.41351124
100CLK10.39908005
101ABL20.39120202
102STK240.38912914
103MAP2K10.38266176
104BTK0.36958204
105LYN0.36838672
106AKT20.36579735
107MAP3K20.36524364
108RPS6KA40.36145666
109CDK80.35992329
110PRKAA20.35905427
111MARK30.35404982
112FGR0.35354452
113MTOR0.35217188
114PRKACG0.34932381
115AKT10.34610601
116PTK2B0.33800206
117TAOK30.33050880
118MAPK140.33035925
119MAP2K40.32254229
120MAPK30.30499032
121PDK30.29949193
122PDK40.29949193
123PLK40.29755442
124SGK20.29360452
125CSNK2A10.28378662
126CDK150.25974658
127IKBKE0.25607238
128DYRK1A0.25448797
129GSK3B0.25198162
130RPS6KA10.24271947
131RPS6KA30.24074389
132DAPK20.23363931
133CDK11A0.22485506
134CSNK2A20.21887182
135PKN10.21009389
136LRRK20.20884317

Predicted pathways (KEGG)

RankGene SetZ-score
1Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008608.54042115
2Systemic lupus erythematosus_Homo sapiens_hsa053226.68619229
3Vitamin B6 metabolism_Homo sapiens_hsa007505.39650185
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005245.39481925
5Alcoholism_Homo sapiens_hsa050343.58413650
6DNA replication_Homo sapiens_hsa030303.39233303
7Cell cycle_Homo sapiens_hsa041102.86634447
8Mismatch repair_Homo sapiens_hsa034302.03817281
9Viral carcinogenesis_Homo sapiens_hsa052031.98438678
10One carbon pool by folate_Homo sapiens_hsa006701.74125945
11ABC transporters_Homo sapiens_hsa020101.65822863
12Fanconi anemia pathway_Homo sapiens_hsa034601.60560850
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.60128376
14Homologous recombination_Homo sapiens_hsa034401.59162730
15Nucleotide excision repair_Homo sapiens_hsa034201.47714089
16African trypanosomiasis_Homo sapiens_hsa051431.44278548
17Regulation of autophagy_Homo sapiens_hsa041401.42957175
18Base excision repair_Homo sapiens_hsa034101.39219726
19Hematopoietic cell lineage_Homo sapiens_hsa046401.39156704
20p53 signaling pathway_Homo sapiens_hsa041151.38144412
21RNA transport_Homo sapiens_hsa030131.33768987
22Acute myeloid leukemia_Homo sapiens_hsa052211.33320142
23Malaria_Homo sapiens_hsa051441.25862965
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.17489928
25Bladder cancer_Homo sapiens_hsa052191.14659413
26Spliceosome_Homo sapiens_hsa030401.09649726
27Selenocompound metabolism_Homo sapiens_hsa004501.07579977
28Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.07232512
29Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.06989343
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.06635132
31Sulfur relay system_Homo sapiens_hsa041221.05483601
32Non-homologous end-joining_Homo sapiens_hsa034501.04314442
33Collecting duct acid secretion_Homo sapiens_hsa049661.01062246
34Renal cell carcinoma_Homo sapiens_hsa052111.00257900
35Non-small cell lung cancer_Homo sapiens_hsa052230.98401260
36mRNA surveillance pathway_Homo sapiens_hsa030150.91913171
37Type II diabetes mellitus_Homo sapiens_hsa049300.91031115
38Transcriptional misregulation in cancer_Homo sapiens_hsa052020.90620991
39Oocyte meiosis_Homo sapiens_hsa041140.89362849
40Small cell lung cancer_Homo sapiens_hsa052220.87626694
41Chronic myeloid leukemia_Homo sapiens_hsa052200.85422223
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85028754
43Herpes simplex infection_Homo sapiens_hsa051680.80130725
44Glycerophospholipid metabolism_Homo sapiens_hsa005640.77217912
45Jak-STAT signaling pathway_Homo sapiens_hsa046300.76724431
46Pyrimidine metabolism_Homo sapiens_hsa002400.74014549
47Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72036942
48Glutathione metabolism_Homo sapiens_hsa004800.69510979
49Ribosome_Homo sapiens_hsa030100.68984104
50Dorso-ventral axis formation_Homo sapiens_hsa043200.63958277
51Lysine degradation_Homo sapiens_hsa003100.61547312
52Inositol phosphate metabolism_Homo sapiens_hsa005620.61453105
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60558980
54Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.60365948
55MicroRNAs in cancer_Homo sapiens_hsa052060.59326844
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58911935
57Fructose and mannose metabolism_Homo sapiens_hsa000510.58175839
58Pyruvate metabolism_Homo sapiens_hsa006200.57890750
59Cysteine and methionine metabolism_Homo sapiens_hsa002700.57143764
60B cell receptor signaling pathway_Homo sapiens_hsa046620.56342721
61RNA degradation_Homo sapiens_hsa030180.56138860
62Fatty acid biosynthesis_Homo sapiens_hsa000610.55314236
63Prolactin signaling pathway_Homo sapiens_hsa049170.54688044
64Endometrial cancer_Homo sapiens_hsa052130.53482052
65Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52258963
66AMPK signaling pathway_Homo sapiens_hsa041520.51767942
67Pancreatic cancer_Homo sapiens_hsa052120.46985124
68HTLV-I infection_Homo sapiens_hsa051660.45466863
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45173962
70Mineral absorption_Homo sapiens_hsa049780.44914726
71Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44172712
72Hepatitis B_Homo sapiens_hsa051610.44020799
73Proteasome_Homo sapiens_hsa030500.43601875
74Choline metabolism in cancer_Homo sapiens_hsa052310.42655192
75Carbon metabolism_Homo sapiens_hsa012000.41804621
76Prostate cancer_Homo sapiens_hsa052150.41405642
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39999610
78Biosynthesis of amino acids_Homo sapiens_hsa012300.39879941
79Nitrogen metabolism_Homo sapiens_hsa009100.38306305
80FoxO signaling pathway_Homo sapiens_hsa040680.37669151
81Glioma_Homo sapiens_hsa052140.37388589
82Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37019279
83Epstein-Barr virus infection_Homo sapiens_hsa051690.36430650
84Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.33869702
85AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.33719729
86Purine metabolism_Homo sapiens_hsa002300.32539724
87* Apoptosis_Homo sapiens_hsa042100.32171600
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31969179
89VEGF signaling pathway_Homo sapiens_hsa043700.30662638
90Measles_Homo sapiens_hsa051620.29992274
91Melanoma_Homo sapiens_hsa052180.29608759
92Thyroid cancer_Homo sapiens_hsa052160.29181135
93Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.28081752
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27691116
95NOD-like receptor signaling pathway_Homo sapiens_hsa046210.25715818
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25669871
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.25578965
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.24751944
992-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.24484442
100Basal transcription factors_Homo sapiens_hsa030220.23529234
101ErbB signaling pathway_Homo sapiens_hsa040120.22363175
102Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.20378011
103Complement and coagulation cascades_Homo sapiens_hsa046100.19469433
104HIF-1 signaling pathway_Homo sapiens_hsa040660.16954222
105Pentose phosphate pathway_Homo sapiens_hsa000300.16732119
106Influenza A_Homo sapiens_hsa051640.15714381
107Huntingtons disease_Homo sapiens_hsa050160.15620498
108Parkinsons disease_Homo sapiens_hsa050120.15517062
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.14813032
110RNA polymerase_Homo sapiens_hsa030200.14525720
111Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.14091120
112Metabolic pathways_Homo sapiens_hsa011000.14067180
113Platelet activation_Homo sapiens_hsa046110.12914582
114Antigen processing and presentation_Homo sapiens_hsa046120.12758962
115Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.12327223
116Insulin resistance_Homo sapiens_hsa049310.11247270
117Insulin signaling pathway_Homo sapiens_hsa049100.09351233
118Central carbon metabolism in cancer_Homo sapiens_hsa052300.08440797
119Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.07709612
120Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.07391879
121Fatty acid degradation_Homo sapiens_hsa000710.07131502
122mTOR signaling pathway_Homo sapiens_hsa041500.05904334
123Bile secretion_Homo sapiens_hsa049760.05475154
124Cyanoamino acid metabolism_Homo sapiens_hsa004600.04906174
125Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.03783030
126Thyroid hormone signaling pathway_Homo sapiens_hsa049190.03354362
127Hepatitis C_Homo sapiens_hsa051600.02972184

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