SPSB4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1paraxial mesoderm development (GO:0048339)6.72017002
2lung-associated mesenchyme development (GO:0060484)5.07443596
3dopaminergic neuron differentiation (GO:0071542)4.50251414
4pyrimidine nucleobase catabolic process (GO:0006208)4.23958364
5negative regulation of smooth muscle cell differentiation (GO:0051151)4.12388586
6lung epithelium development (GO:0060428)4.07489040
7embryonic foregut morphogenesis (GO:0048617)3.71496064
8presynaptic membrane assembly (GO:0097105)3.61389368
9regulation of gene silencing by RNA (GO:0060966)3.46344559
10regulation of posttranscriptional gene silencing (GO:0060147)3.46344559
11regulation of gene silencing by miRNA (GO:0060964)3.46344559
12cardiac cell development (GO:0055006)3.44760195
13presynaptic membrane organization (GO:0097090)3.44503890
14positive regulation of gastrulation (GO:2000543)3.43376966
15neuronal stem cell maintenance (GO:0097150)3.42906605
16viral transcription (GO:0019083)3.42389749
17neuron projection extension involved in neuron projection guidance (GO:1902284)3.40701745
18axon extension involved in axon guidance (GO:0048846)3.40701745
19translational termination (GO:0006415)3.39223949
20cardiac myofibril assembly (GO:0055003)3.39038247
21G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.37381351
22cardiac muscle cell development (GO:0055013)3.36281218
23ventricular cardiac muscle cell development (GO:0055015)3.35741475
24mitotic metaphase plate congression (GO:0007080)3.31001730
25glomerular filtration (GO:0003094)3.28661954
26regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.28549126
27purine nucleobase biosynthetic process (GO:0009113)3.26080159
28negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.23082513
29negative regulation of striated muscle cell apoptotic process (GO:0010664)3.20024249
30adult heart development (GO:0007512)3.16517118
31postsynaptic membrane organization (GO:0001941)3.15617880
32vitamin transmembrane transport (GO:0035461)3.14098993
33mesenchyme development (GO:0060485)3.12612596
34sarcomere organization (GO:0045214)3.12219606
35glomerular basement membrane development (GO:0032836)3.12016170
36artery development (GO:0060840)3.11531250
37mesenchyme morphogenesis (GO:0072132)3.09213806
38nucleobase catabolic process (GO:0046113)3.07770032
39convergent extension (GO:0060026)3.04910974
40regulation of cardioblast differentiation (GO:0051890)3.04026907
41regulation of mesenchymal cell apoptotic process (GO:2001053)3.03328143
42cardiac right ventricle morphogenesis (GO:0003215)3.00313210
43endocardial cushion morphogenesis (GO:0003203)3.00019844
44establishment of planar polarity (GO:0001736)2.96745895
45establishment of tissue polarity (GO:0007164)2.96745895
46somite development (GO:0061053)2.95501735
47cell proliferation involved in metanephros development (GO:0072203)2.93014580
48ribosomal small subunit assembly (GO:0000028)2.90705554
49heterochromatin organization (GO:0070828)2.88582988
50muscle filament sliding (GO:0030049)2.88496089
51actin-myosin filament sliding (GO:0033275)2.88496089
52left/right axis specification (GO:0070986)2.86816550
53cranial nerve development (GO:0021545)2.86109596
54negative regulation of DNA-templated transcription, elongation (GO:0032785)2.85281978
55negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.85281978
56outer ear morphogenesis (GO:0042473)2.83283615
57folic acid metabolic process (GO:0046655)2.82779946
58renal filtration (GO:0097205)2.82106885
59planar cell polarity pathway involved in neural tube closure (GO:0090179)2.81654076
60thalamus development (GO:0021794)2.81470162
61axonal fasciculation (GO:0007413)2.81335929
62mesenchymal cell proliferation (GO:0010463)2.79958643
63nucleobase biosynthetic process (GO:0046112)2.77172318
64translational elongation (GO:0006414)2.77168692
65behavioral response to nicotine (GO:0035095)2.76368223
66pre-miRNA processing (GO:0031054)2.76030266
67DNA replication checkpoint (GO:0000076)2.73834026
68cardiac muscle tissue morphogenesis (GO:0055008)2.72911780
69DNA damage response, detection of DNA damage (GO:0042769)2.72368910
70chromatin remodeling at centromere (GO:0031055)2.71014785
71negative regulation of axon guidance (GO:1902668)2.70893065
72Notch signaling involved in heart development (GO:0061314)2.70590081
73midbrain development (GO:0030901)2.70327007
74nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.68991492
75regulation of smooth muscle cell differentiation (GO:0051150)2.68802903
76face development (GO:0060324)2.68658122
77heart process (GO:0003015)2.67552898
78heart contraction (GO:0060047)2.67552898
79tricarboxylic acid cycle (GO:0006099)2.67040248
80cardiac muscle contraction (GO:0060048)2.66935659
81cellular protein complex disassembly (GO:0043624)2.66778904
82negative regulation of potassium ion transmembrane transport (GO:1901380)2.66213674
83mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.65833981
84generation of neurons (GO:0048699)2.64818750
85spinal cord development (GO:0021510)2.64460526
86ventricular cardiac muscle cell action potential (GO:0086005)2.64310843
87SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.64246831
88metaphase plate congression (GO:0051310)2.64009763
89limb bud formation (GO:0060174)2.63199726
90outflow tract septum morphogenesis (GO:0003148)2.62358848
91retinal ganglion cell axon guidance (GO:0031290)2.62180688
92protein complex disassembly (GO:0043241)2.62086579
93lens fiber cell development (GO:0070307)2.62076228
94negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.62047924
95atrial septum morphogenesis (GO:0060413)2.61475547
96notochord development (GO:0030903)2.61456864
97cotranslational protein targeting to membrane (GO:0006613)2.61405094
98myofibril assembly (GO:0030239)2.61061229
99cell migration in hindbrain (GO:0021535)2.60254052
100epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.60213840
101folic acid transport (GO:0015884)2.59823203
102gap junction assembly (GO:0016264)2.59608926
103regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.58772521
104cell surface receptor signaling pathway involved in heart development (GO:0061311)2.58282868
105urate metabolic process (GO:0046415)2.55700006
106positive regulation of BMP signaling pathway (GO:0030513)2.55586746
107actin-mediated cell contraction (GO:0070252)2.55488177
108modified amino acid transport (GO:0072337)2.53889041
109DNA strand elongation involved in DNA replication (GO:0006271)2.53650601
110protein targeting to ER (GO:0045047)2.53505774
111dorsal/ventral neural tube patterning (GO:0021904)2.52749101
112macromolecular complex disassembly (GO:0032984)2.52561633
113neuron recognition (GO:0008038)2.51966762
114establishment of integrated proviral latency (GO:0075713)2.51266002
115regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.51097939
116nucleosome disassembly (GO:0006337)2.51068223
117protein-DNA complex disassembly (GO:0032986)2.51068223
118regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.50006797
119regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.49735327
120head development (GO:0060322)2.49464849
121lateral sprouting from an epithelium (GO:0060601)2.48446943
122positive regulation of oligodendrocyte differentiation (GO:0048714)2.48370638
123ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.48023282
124negative regulation of epidermal cell differentiation (GO:0045605)2.47835442
125negative regulation of epidermis development (GO:0045683)2.47153837
126establishment of protein localization to endoplasmic reticulum (GO:0072599)2.46839402
127regulation of mesoderm development (GO:2000380)2.46776136
128viral life cycle (GO:0019058)2.46431940
129atrial cardiac muscle cell action potential (GO:0086014)2.46350183
130DNA unwinding involved in DNA replication (GO:0006268)2.45897972
131DNA replication-dependent nucleosome assembly (GO:0006335)2.45634075
132DNA replication-dependent nucleosome organization (GO:0034723)2.45634075
133serine family amino acid catabolic process (GO:0009071)2.44370221
134heart valve formation (GO:0003188)2.44243364
135nonmotile primary cilium assembly (GO:0035058)2.43828106
136regulation of transforming growth factor beta2 production (GO:0032909)2.43425046
137astrocyte differentiation (GO:0048708)2.42928654
138regulation of organ formation (GO:0003156)2.41665342
139negative regulation of embryonic development (GO:0045992)2.40665194
140uterus development (GO:0060065)2.40082304
141limb development (GO:0060173)2.39167897
142appendage development (GO:0048736)2.39167897
143L-serine metabolic process (GO:0006563)2.39167365
144spliceosomal snRNP assembly (GO:0000387)2.39117307
145muscle tissue morphogenesis (GO:0060415)2.37223536
146spindle checkpoint (GO:0031577)2.37086981
147CENP-A containing nucleosome assembly (GO:0034080)2.36942460
148regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.35145618
149DNA strand elongation (GO:0022616)2.35082908
150regulation of striated muscle cell apoptotic process (GO:0010662)2.34850792
151translational initiation (GO:0006413)2.34151583
152ribosomal small subunit biogenesis (GO:0042274)2.33572178
153positive regulation of catenin import into nucleus (GO:0035413)2.32904579
154protein localization to endoplasmic reticulum (GO:0070972)2.32290118
155urogenital system development (GO:0001655)2.31362812
156maturation of SSU-rRNA (GO:0030490)2.28371854
157ventricular trabecula myocardium morphogenesis (GO:0003222)2.28142622
158ATP-dependent chromatin remodeling (GO:0043044)2.26967662
159mesenchymal to epithelial transition (GO:0060231)2.26966490
160positive regulation of SMAD protein import into nucleus (GO:0060391)2.26800867
161microtubule depolymerization (GO:0007019)2.26328271
162establishment of protein localization to mitochondrial membrane (GO:0090151)2.24422110
163histone exchange (GO:0043486)2.23412666
164histone arginine methylation (GO:0034969)2.23322785
165enteric nervous system development (GO:0048484)2.23054739
166cochlea morphogenesis (GO:0090103)2.22185672
167hindbrain development (GO:0030902)2.21527329
168DNA replication-independent nucleosome organization (GO:0034724)2.19665596
169DNA replication-independent nucleosome assembly (GO:0006336)2.19665596
170spinal cord association neuron differentiation (GO:0021527)2.19505900
171regulation of non-canonical Wnt signaling pathway (GO:2000050)2.18966372
172short-term memory (GO:0007614)2.17389704
173neuron cell-cell adhesion (GO:0007158)2.17038814
174cellular response to cholesterol (GO:0071397)2.16124455
175somite rostral/caudal axis specification (GO:0032525)2.15809034
176regulation of stem cell maintenance (GO:2000036)2.14888638
177cell differentiation in spinal cord (GO:0021515)2.12659160
178nerve development (GO:0021675)2.12442963
179pituitary gland development (GO:0021983)2.12187843
180regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.12103973

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.52821545
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.17619302
3EZH2_22144423_ChIP-Seq_EOC_Human4.16414884
4TP63_19390658_ChIP-ChIP_HaCaT_Human3.81655101
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.36051044
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.15493515
7AR_21909140_ChIP-Seq_LNCAP_Human3.01766857
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.83455878
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.82792752
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.81639281
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.78640219
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.65786262
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.56176109
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.46278724
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.44844800
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.40522306
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.35113707
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.33216770
19CBX2_27304074_Chip-Seq_ESCs_Mouse2.32676271
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.20997321
21CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.19877914
22MYC_18358816_ChIP-ChIP_MESCs_Mouse2.19630557
23ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.09669527
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.03319556
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.01804870
26MYC_19079543_ChIP-ChIP_MESCs_Mouse2.00231410
27NANOG_18555785_ChIP-Seq_MESCs_Mouse1.94388666
28NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.92741318
29KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.90413815
30JARID2_20064375_ChIP-Seq_MESCs_Mouse1.89476030
31* EED_16625203_ChIP-ChIP_MESCs_Mouse1.88917109
32ETS1_20019798_ChIP-Seq_JURKAT_Human1.87862424
33CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.83198742
34XRN2_22483619_ChIP-Seq_HELA_Human1.82456239
35NANOG_21062744_ChIP-ChIP_HESCs_Human1.82256951
36POU5F1_16153702_ChIP-ChIP_HESCs_Human1.82247007
37BMI1_23680149_ChIP-Seq_NPCS_Mouse1.82071184
38* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.81258284
39EST1_17652178_ChIP-ChIP_JURKAT_Human1.81034949
40E2F1_18555785_ChIP-Seq_MESCs_Mouse1.69902462
41RNF2_27304074_Chip-Seq_NSC_Mouse1.69575779
42E2F1_21310950_ChIP-Seq_MCF-7_Human1.66442766
43* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.61331014
44POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.60674234
45SOX2_18555785_ChIP-Seq_MESCs_Mouse1.59855468
46* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.57734168
47IGF1R_20145208_ChIP-Seq_DFB_Human1.56132944
48* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.55446728
49* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.55446728
50POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.54860586
51CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.54522780
52YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53215320
53CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.53022288
54FUS_26573619_Chip-Seq_HEK293_Human1.51433447
55TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.50823486
56GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.50631736
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.50326558
58NANOG_16153702_ChIP-ChIP_HESCs_Human1.49391435
59HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.48713778
60TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47952687
61POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.47952687
62PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.47403217
63EGR1_19374776_ChIP-ChIP_THP-1_Human1.46848776
64VDR_22108803_ChIP-Seq_LS180_Human1.46567993
65MYCN_18555785_ChIP-Seq_MESCs_Mouse1.46454650
66EWS_26573619_Chip-Seq_HEK293_Human1.46388333
67ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.45525258
68EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.44537621
69* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.44260547
70SOX2_16153702_ChIP-ChIP_HESCs_Human1.43571826
71TTF2_22483619_ChIP-Seq_HELA_Human1.43264801
72RNF2_27304074_Chip-Seq_ESCs_Mouse1.43017729
73TRIM28_21343339_ChIP-Seq_HEK293_Human1.42902387
74EZH2_27294783_Chip-Seq_ESCs_Mouse1.42485582
75GABP_17652178_ChIP-ChIP_JURKAT_Human1.42128372
76POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.41482472
77MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.40954908
78CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39887112
79GABP_19822575_ChIP-Seq_HepG2_Human1.39594128
80SOX2_18692474_ChIP-Seq_MEFs_Mouse1.38927289
81* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.38630461
82TCF3_18692474_ChIP-Seq_MEFs_Mouse1.38429050
83ZNF274_21170338_ChIP-Seq_K562_Hela1.35360825
84* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.32602011
85KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.32190583
86KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.32190583
87KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.32190583
88* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.32112168
89SUZ12_27294783_Chip-Seq_ESCs_Mouse1.31974703
90MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.31861346
91THAP11_20581084_ChIP-Seq_MESCs_Mouse1.31591273
92RING1B_27294783_Chip-Seq_ESCs_Mouse1.31147849
93ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29115894
94ZFP281_18757296_ChIP-ChIP_E14_Mouse1.29086320
95YY1_21170310_ChIP-Seq_MESCs_Mouse1.26516193
96REST_21632747_ChIP-Seq_MESCs_Mouse1.26024402
97GBX2_23144817_ChIP-Seq_PC3_Human1.25808216
98ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.25342563
99TAF15_26573619_Chip-Seq_HEK293_Human1.25274199
100P300_19829295_ChIP-Seq_ESCs_Human1.25070703
101DCP1A_22483619_ChIP-Seq_HELA_Human1.23886498
102RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23835449
103KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.23758725
104* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.22912675
105* RING1B_27294783_Chip-Seq_NPCs_Mouse1.22360252
106GATA1_26923725_Chip-Seq_HPCs_Mouse1.17390985
107HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.17055833
108PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15172855
109SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.14524890
110SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.14043510
111CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.13314516
112TCF3_18692474_ChIP-Seq_MESCs_Mouse1.11485840
113OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.11161445
114ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.11105744
115POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.10303416
116MYC_18940864_ChIP-ChIP_HL60_Human1.09913936
117* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.09540146
118* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09482705
119CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08677961
120NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.08521980
121RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.08153887
122* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08017528
123REST_18959480_ChIP-ChIP_MESCs_Mouse1.06427260
124KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05968238
125ERG_21242973_ChIP-ChIP_JURKAT_Human1.04704069
126HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.04696009
127GATA4_21415370_ChIP-Seq_HL-1_Mouse1.04641692
128NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.04588768
129TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04063442
130SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.04028074
131* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.03718694
132ZFP57_27257070_Chip-Seq_ESCs_Mouse1.02107462
133TBX3_20139965_ChIP-Seq_MESCs_Mouse1.02040362
134* TP53_20018659_ChIP-ChIP_R1E_Mouse1.01954189
135SALL4_18804426_ChIP-ChIP_XEN_Mouse1.01820404
136SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.01354569
137STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01334749
138TBX3_20139965_ChIP-Seq_ESCs_Mouse1.01246372
139CIITA_25753668_ChIP-Seq_RAJI_Human1.00604479
140OCT4_18692474_ChIP-Seq_MEFs_Mouse1.00316625
141* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.00195704
142SOX17_20123909_ChIP-Seq_XEN_Mouse1.00002720
143SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.99216800
144SMAD3_21741376_ChIP-Seq_EPCs_Human0.98790945
145SOX9_26525672_Chip-Seq_HEART_Mouse0.98699079
146CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97547091
147SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97382472
148POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.95238293
149CLOCK_20551151_ChIP-Seq_293T_Human0.94430393
150NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.94107594
151PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.93493061
152PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.92133478
153ISL1_27105846_Chip-Seq_CPCs_Mouse0.91770156
154KDM5A_27292631_Chip-Seq_BREAST_Human0.91215911
155SALL1_21062744_ChIP-ChIP_HESCs_Human0.89697186
156MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.88913469
157PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.87236542

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis3.66341675
2MP0010030_abnormal_orbit_morphology3.36781909
3MP0009053_abnormal_anal_canal3.14919353
4MP0002653_abnormal_ependyma_morphology2.96198590
5MP0000537_abnormal_urethra_morphology2.74110190
6MP0003693_abnormal_embryo_hatching2.53614728
7MP0003123_paternal_imprinting2.47009039
8MP0004084_abnormal_cardiac_muscle2.40796873
9MP0006292_abnormal_olfactory_placode2.30723844
10MP0001529_abnormal_vocalization2.15926210
11MP0005257_abnormal_intraocular_pressure2.04137838
12MP0003122_maternal_imprinting2.03476418
13MP0003283_abnormal_digestive_organ1.99966178
14MP0003315_abnormal_perineum_morphology1.99929069
15MP0002822_catalepsy1.98611341
16MP0004133_heterotaxia1.97243838
17MP0009379_abnormal_foot_pigmentation1.93908786
18MP0003646_muscle_fatigue1.90663755
19MP0003878_abnormal_ear_physiology1.89126300
20MP0005377_hearing/vestibular/ear_phenot1.89126300
21MP0008932_abnormal_embryonic_tissue1.83509727
22MP0003119_abnormal_digestive_system1.81764885
23MP0002751_abnormal_autonomic_nervous1.80192808
24MP0005423_abnormal_somatic_nervous1.78828838
25MP0003942_abnormal_urinary_system1.78297868
26MP0004233_abnormal_muscle_weight1.77386396
27MP0003111_abnormal_nucleus_morphology1.74877144
28MP0001346_abnormal_lacrimal_gland1.73157372
29MP0000049_abnormal_middle_ear1.71690360
30MP0003137_abnormal_impulse_conducting1.68068259
31MP0003121_genomic_imprinting1.67871423
32MP0002938_white_spotting1.66417704
33MP0003880_abnormal_central_pattern1.66024855
34MP0003077_abnormal_cell_cycle1.64154641
35MP0003567_abnormal_fetal_cardiomyocyte1.64024960
36MP0003787_abnormal_imprinting1.62648324
37MP0003115_abnormal_respiratory_system1.62348564
38MP0003937_abnormal_limbs/digits/tail_de1.59863463
39MP0002282_abnormal_trachea_morphology1.56761534
40MP0005451_abnormal_body_composition1.56720384
41MP0001293_anophthalmia1.55133143
42MP0003718_maternal_effect1.53403999
43MP0003938_abnormal_ear_development1.51447844
44MP0000631_abnormal_neuroendocrine_gland1.46349115
45MP0000428_abnormal_craniofacial_morphol1.43847964
46MP0009672_abnormal_birth_weight1.43507184
47MP0006276_abnormal_autonomic_nervous1.43431675
48MP0000955_abnormal_spinal_cord1.40774961
49MP0004957_abnormal_blastocyst_morpholog1.40119054
50MP0010094_abnormal_chromosome_stability1.38160309
51MP0004145_abnormal_muscle_electrophysio1.37237287
52MP0002697_abnormal_eye_size1.36594006
53MP0001730_embryonic_growth_arrest1.36084507
54MP0005171_absent_coat_pigmentation1.36010033
55MP0005380_embryogenesis_phenotype1.35778087
56MP0001672_abnormal_embryogenesis/_devel1.35778087
57MP0003890_abnormal_embryonic-extraembry1.35482042
58MP0005499_abnormal_olfactory_system1.34505382
59MP0005394_taste/olfaction_phenotype1.34505382
60MP0002638_abnormal_pupillary_reflex1.34423032
61MP0005330_cardiomyopathy1.33355744
62MP0002085_abnormal_embryonic_tissue1.33258425
63MP0003221_abnormal_cardiomyocyte_apopto1.32913302
64MP0002084_abnormal_developmental_patter1.29974670
65MP0002972_abnormal_cardiac_muscle1.28435789
66MP0003984_embryonic_growth_retardation1.26998526
67MP0002111_abnormal_tail_morphology1.26383960
68MP0006138_congestive_heart_failure1.26139975
69MP0002088_abnormal_embryonic_growth/wei1.25797036
70MP0001984_abnormal_olfaction1.25543893
71MP0004197_abnormal_fetal_growth/weight/1.24951632
72MP0001286_abnormal_eye_development1.24258582
73MP0002249_abnormal_larynx_morphology1.24094880
74MP0002234_abnormal_pharynx_morphology1.24091627
75MP0006072_abnormal_retinal_apoptosis1.23985821
76MP0002184_abnormal_innervation1.23289317
77MP0002102_abnormal_ear_morphology1.22909721
78MP0002932_abnormal_joint_morphology1.22806358
79MP0000534_abnormal_ureter_morphology1.22596163
80MP0001299_abnormal_eye_distance/1.15662404
81MP0002837_dystrophic_cardiac_calcinosis1.15595372
82MP0001697_abnormal_embryo_size1.14639359
83MP0005360_urolithiasis1.14163048
84MP0002116_abnormal_craniofacial_bone1.12916579
85MP0005391_vision/eye_phenotype1.12883606
86MP0004859_abnormal_synaptic_plasticity1.12508137
87MP0008877_abnormal_DNA_methylation1.12100479
88MP0004215_abnormal_myocardial_fiber1.11802526
89MP0005248_abnormal_Harderian_gland1.11414050
90MP0002152_abnormal_brain_morphology1.09291138
91MP0000350_abnormal_cell_proliferation1.09209678
92MP0003828_pulmonary_edema1.08951681
93MP0002752_abnormal_somatic_nervous1.07398097
94MP0003385_abnormal_body_wall1.07125308
95MP0002127_abnormal_cardiovascular_syste1.06783951
96MP0004858_abnormal_nervous_system1.05740475
97MP0003755_abnormal_palate_morphology1.04543618
98MP0001544_abnormal_cardiovascular_syste1.03410813
99MP0005385_cardiovascular_system_phenoty1.03410813
100MP0001485_abnormal_pinna_reflex1.02734498
101MP0002557_abnormal_social/conspecific_i1.02233781
102MP0003935_abnormal_craniofacial_develop1.02221212
103MP0002092_abnormal_eye_morphology1.02058530
104MP0000749_muscle_degeneration1.00520570
105MP0010630_abnormal_cardiac_muscle0.99883851
106MP0003861_abnormal_nervous_system0.99856643
107MP0005253_abnormal_eye_physiology0.99444789
108MP0003941_abnormal_skin_development0.98639593
109MP0008058_abnormal_DNA_repair0.98529687
110MP0001486_abnormal_startle_reflex0.98483763
111MP0005508_abnormal_skeleton_morphology0.97884719
112MP0002734_abnormal_mechanical_nocicepti0.95852248
113MP0002081_perinatal_lethality0.95836759
114MP0002882_abnormal_neuron_morphology0.95502918
115MP0009250_abnormal_appendicular_skeleto0.95421494
116MP0004036_abnormal_muscle_relaxation0.93708907
117MP0000750_abnormal_muscle_regeneration0.93234083
118MP0005332_abnormal_amino_acid0.93228426
119MP0003635_abnormal_synaptic_transmissio0.92528177
120MP0005408_hypopigmentation0.90794442
121MP0000026_abnormal_inner_ear0.90747241
122MP0002736_abnormal_nociception_after0.90375373
123MP0005620_abnormal_muscle_contractility0.89546953
124MP0002233_abnormal_nose_morphology0.89470768
125MP0003136_yellow_coat_color0.89415456
126MP0009703_decreased_birth_body0.88902316
127MP0005197_abnormal_uvea_morphology0.88170470
128MP0008789_abnormal_olfactory_epithelium0.87769632
129MP0000462_abnormal_digestive_system0.86996559
130MP0002080_prenatal_lethality0.85816164
131MP0002735_abnormal_chemical_nociception0.85580743
132MP0005195_abnormal_posterior_eye0.83679115
133MP0005187_abnormal_penis_morphology0.83667367
134MP0004742_abnormal_vestibular_system0.83598692
135MP0004087_abnormal_muscle_fiber0.83402638
136MP0000516_abnormal_urinary_system0.83038085
137MP0005367_renal/urinary_system_phenotyp0.83038085
138MP0005076_abnormal_cell_differentiation0.82712795
139MP0000778_abnormal_nervous_system0.82434102
140MP0000432_abnormal_head_morphology0.80001217

Predicted human phenotypes

RankGene SetZ-score
1Congenital malformation of the right heart (HP:0011723)4.01540157
2Double outlet right ventricle (HP:0001719)4.01540157
3Colon cancer (HP:0003003)3.82662348
4Maternal diabetes (HP:0009800)3.51754939
5Hyperglycinuria (HP:0003108)3.43590307
6Short middle phalanx of the 5th finger (HP:0004220)3.34314395
7Abnormality of the anterior horn cell (HP:0006802)3.19177207
8Degeneration of anterior horn cells (HP:0002398)3.19177207
9Hepatoblastoma (HP:0002884)3.13297820
10Gout (HP:0001997)2.91504066
11Carpal bone hypoplasia (HP:0001498)2.88851490
12Abnormal pancreas size (HP:0012094)2.85734472
13Reticulocytopenia (HP:0001896)2.85296382
14Patellar aplasia (HP:0006443)2.80232396
15Concave nail (HP:0001598)2.78375872
16Rib fusion (HP:0000902)2.71579057
17Aplasia/Hypoplasia of the patella (HP:0006498)2.69781178
18Abnormality of the labia minora (HP:0012880)2.68192362
19Renal duplication (HP:0000075)2.65551577
20Septo-optic dysplasia (HP:0100842)2.65194343
21Bifid tongue (HP:0010297)2.64489954
22Abnormality of glycine metabolism (HP:0010895)2.53520956
23Abnormality of serine family amino acid metabolism (HP:0010894)2.53520956
24Oligodactyly (HP:0012165)2.51415340
25Proximal tubulopathy (HP:0000114)2.50331709
26Oligodactyly (hands) (HP:0001180)2.49706185
27Ventricular tachycardia (HP:0004756)2.44919613
28Vitreoretinal degeneration (HP:0000655)2.42332176
29Esophageal atresia (HP:0002032)2.41756031
30Partial duplication of thumb phalanx (HP:0009944)2.39846697
31Aplasia of the musculature (HP:0100854)2.39731392
32Sudden death (HP:0001699)2.39238408
33Abnormality of the intervertebral disk (HP:0005108)2.38739783
34Truncus arteriosus (HP:0001660)2.37408030
35Bicornuate uterus (HP:0000813)2.37023225
36Hemivertebrae (HP:0002937)2.36729562
37Anophthalmia (HP:0000528)2.36415209
38Aplasia/Hypoplasia involving the musculature (HP:0001460)2.30946560
39High anterior hairline (HP:0009890)2.29563207
40Cortical dysplasia (HP:0002539)2.28856078
41Intestinal atresia (HP:0011100)2.26633919
42Hypoplastic ischia (HP:0003175)2.24492337
43Neoplasm of the adrenal gland (HP:0100631)2.24416659
44Partial duplication of the phalanx of hand (HP:0009999)2.23850283
45Exercise-induced muscle cramps (HP:0003710)2.23782392
46Generalized aminoaciduria (HP:0002909)2.22477618
47Cutaneous finger syndactyly (HP:0010554)2.22414482
48Anencephaly (HP:0002323)2.22339804
49Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.22178221
50Abnormal number of incisors (HP:0011064)2.21894420
51Optic nerve coloboma (HP:0000588)2.21881287
52Abnormality of the 4th metacarpal (HP:0010012)2.21567340
53Nausea (HP:0002018)2.21297557
54Nephronophthisis (HP:0000090)2.21278764
55Hyperuricemia (HP:0002149)2.20991829
56Increased purine levels (HP:0004368)2.20991829
57Hyperglycinemia (HP:0002154)2.20925373
58Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.20867596
59Midline defect of the nose (HP:0004122)2.20817683
60Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.20737663
61Abnormality of urine glucose concentration (HP:0011016)2.20718584
62Glycosuria (HP:0003076)2.20718584
63Abnormality of the ischium (HP:0003174)2.19947495
64Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.19443083
65Short 4th metacarpal (HP:0010044)2.19443083
66Growth hormone deficiency (HP:0000824)2.18502100
67Cutaneous syndactyly (HP:0012725)2.14967820
68Myelomeningocele (HP:0002475)2.14535475
69Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.13630728
70Osteomalacia (HP:0002749)2.13386062
71Short 5th finger (HP:0009237)2.11537675
72Breast hypoplasia (HP:0003187)2.07710242
73Lipoatrophy (HP:0100578)2.04685081
74Gastrointestinal atresia (HP:0002589)2.04642247
75Bilateral microphthalmos (HP:0007633)2.04566290
76Absent septum pellucidum (HP:0001331)2.04094550
77Abnormality of cells of the erythroid lineage (HP:0012130)2.03406255
78Abnormality of the pubic bones (HP:0003172)2.03009088
79Triphalangeal thumb (HP:0001199)2.02805903
80Aplasia/Hypoplasia of the uvula (HP:0010293)1.99659332
81Synostosis of carpal bones (HP:0005048)1.99547813
82Sclerocornea (HP:0000647)1.99306921
83Ectopic kidney (HP:0000086)1.98294611
84Enlarged kidneys (HP:0000105)1.97328707
85Pancreatic fibrosis (HP:0100732)1.97322918
86Carpal synostosis (HP:0009702)1.96771821
87Pendular nystagmus (HP:0012043)1.96253237
88Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.95575133
89Anal stenosis (HP:0002025)1.95492748
90Atrial fibrillation (HP:0005110)1.95427118
91Abnormal number of erythroid precursors (HP:0012131)1.94160960
92Duplication of thumb phalanx (HP:0009942)1.94120635
93Meningocele (HP:0002435)1.93645869
94Choanal stenosis (HP:0000452)1.93538726
95Aplasia involving forearm bones (HP:0009822)1.93073309
96Absent forearm bone (HP:0003953)1.93073309
97Polyuria (HP:0000103)1.92210112
98Preaxial hand polydactyly (HP:0001177)1.91392764
99Impulsivity (HP:0100710)1.90144447
100Primary atrial arrhythmia (HP:0001692)1.89991505
101Hypercalciuria (HP:0002150)1.89300602
102Optic nerve hypoplasia (HP:0000609)1.88821618
103Absent epiphyses (HP:0010577)1.88585442
104Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.88585442
105Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.88466746
106Abnormality of the parathyroid morphology (HP:0011766)1.87628193
107Vaginal atresia (HP:0000148)1.87290057
108Trigonocephaly (HP:0000243)1.85911402
109Absent radius (HP:0003974)1.85622634
110Supraventricular tachycardia (HP:0004755)1.85281063
111Chorioretinal coloboma (HP:0000567)1.84553414
112Abnormality of the septum pellucidum (HP:0007375)1.82326902
113Genital tract atresia (HP:0001827)1.82175054
114Prenatal maternal abnormality (HP:0002686)1.81859530
115Preaxial foot polydactyly (HP:0001841)1.81587031
116Pancreatic cysts (HP:0001737)1.81446994
117Hyperglycemia (HP:0003074)1.79993329
118Medulloblastoma (HP:0002885)1.79858632
119Ketoacidosis (HP:0001993)1.78941611
120Muscle fiber splitting (HP:0003555)1.78532730
121Supraventricular arrhythmia (HP:0005115)1.78488138
122True hermaphroditism (HP:0010459)1.78394908
123Diastasis recti (HP:0001540)1.77497362
124Meckel diverticulum (HP:0002245)1.77403854
125Rimmed vacuoles (HP:0003805)1.74960182
126Abnormality of the ileum (HP:0001549)1.74954676
127Abnormality of the phalanges of the 5th finger (HP:0004213)1.74787949
128Horseshoe kidney (HP:0000085)1.74772994
129Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.74691652
130Tubular atrophy (HP:0000092)1.74254524
131Abnormality of the aortic arch (HP:0012303)1.72800002
132Diaphragmatic weakness (HP:0009113)1.72481065
133Hypoglycemic coma (HP:0001325)1.72363139
134Abnormality of the renal medulla (HP:0100957)1.72122419
135Abnormality of the distal phalanges of the toes (HP:0010182)1.71693093
136Birth length less than 3rd percentile (HP:0003561)1.71352051
137Aplasia/Hypoplasia of the sternum (HP:0006714)1.70669951
138Molar tooth sign on MRI (HP:0002419)1.70448619
139Abnormality of midbrain morphology (HP:0002418)1.70448619
140Broad thumb (HP:0011304)1.69845559
141Back pain (HP:0003418)1.69358838
142Partial agenesis of the corpus callosum (HP:0001338)1.69185704
143Renal dysplasia (HP:0000110)1.69175086
144Synostosis involving bones of the hand (HP:0004278)1.68824767
145Chronic hepatic failure (HP:0100626)1.68416949
146Abnormal lung lobation (HP:0002101)1.66548790
147Bundle branch block (HP:0011710)1.66011436
148Abnormal urine output (HP:0012590)1.65974564
149Morphological abnormality of the inner ear (HP:0011390)1.65860451
150Anomalous pulmonary venous return (HP:0010772)1.65699924
151Abnormality of the phalanges of the 2nd finger (HP:0009541)1.65098486
152Renal hypoplasia (HP:0000089)1.64930214
153Atrioventricular block (HP:0001678)1.64921477
154Depressed nasal ridge (HP:0000457)1.64804035
155Vertebral clefting (HP:0008428)1.62693820
156Delayed epiphyseal ossification (HP:0002663)1.61966660
157Natal tooth (HP:0000695)1.61889540
158Abnormality of abdominal situs (HP:0011620)1.61532470
159Abdominal situs inversus (HP:0003363)1.61532470
160Focal motor seizures (HP:0011153)1.61311918
161Shawl scrotum (HP:0000049)1.58640773
162Omphalocele (HP:0001539)1.58487653
163Myokymia (HP:0002411)1.57659339
164Abnormal connection of the cardiac segments (HP:0011545)1.57382692
165Abnormality of the parietal bone (HP:0002696)1.56998405
166Mixed hearing impairment (HP:0000410)1.56916517
167Chromosomal breakage induced by crosslinking agents (HP:0003221)1.56860898
168Drooling (HP:0002307)1.54528796
169Iris coloboma (HP:0000612)1.53681476
170Neoplasm of the oral cavity (HP:0100649)1.53131634
171Retinal dysplasia (HP:0007973)1.52214747
172Abnormality of the diencephalon (HP:0010662)1.51559615

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB24.27110974
2BUB13.11568048
3KSR13.08009456
4STK38L3.07604053
5CASK2.71251169
6WEE12.59772361
7TAF12.51013410
8VRK22.43089975
9SRPK12.37593539
10MKNK12.34217374
11OBSCN2.28510518
12CDK192.23272326
13NEK12.04693426
14PLK41.98000367
15CDC71.97766546
16TNIK1.96766614
17MST1R1.93933404
18NEK21.92974113
19STK241.92731070
20ICK1.85703271
21EIF2AK11.84866601
22TYRO31.83978306
23ACVR1B1.81959339
24BCR1.76575785
25ZAK1.75431183
26SIK31.70658092
27MAP3K101.63307035
28PIK3CA1.62132529
29BCKDK1.60595457
30MAP3K41.58330334
31WNK31.56330727
32FGFR21.55142079
33CDK81.54648055
34BRSK11.49211750
35ERBB21.39257222
36CAMK1G1.35783470
37MELK1.27703434
38MKNK21.27295868
39MAP2K71.26348527
40STK161.24694270
41EPHA41.22633734
42PLK31.21557430
43EIF2AK31.21287133
44EIF2AK21.18930250
45DYRK31.18492275
46TTK1.17609477
47VRK11.17566592
48AKT31.17263954
49PLK11.14616692
50PNCK1.13832489
51TGFBR11.12252528
52DYRK21.12230666
53BRAF1.12018746
54PASK1.09759775
55LIMK11.09385799
56LATS21.08373832
57CHEK21.08289999
58AURKA1.04305869
59CSNK1G21.03671983
60LATS11.02509513
61CAMK1D1.02310729
62NTRK21.00242163
63TAOK20.98155053
64TRIB30.96989122
65MUSK0.95843622
66CSNK1G10.94809625
67ERBB40.92727024
68CDK70.92093042
69CSNK1G30.91763315
70AURKB0.91686131
71WNK40.90849943
72MARK10.90281927
73PRKCG0.88403268
74ILK0.85050566
75BRSK20.84126702
76UHMK10.84006433
77PLK20.83974324
78CSNK1A1L0.83052338
79ADRBK20.82744435
80MYLK0.81742190
81DDR20.81522900
82DMPK0.78712612
83NTRK10.77556651
84MAP3K50.77085500
85MAPK150.75343222
86CDK30.72249956
87MAP4K20.72094770
88CDK40.71439734
89MAP3K80.71353514
90NUAK10.70953050
91DYRK1A0.69892664
92MTOR0.68708997
93ERBB30.68395741
94CDK11A0.67896127
95PAK30.67446035
96FGFR10.66436567
97BRD40.66217617
98TLK10.65685730
99STK30.65308893
100STK40.64268835
101AKT20.63702545
102LMTK20.63119155
103BMPR1B0.62391423
104CDC42BPA0.60343330
105MET0.59922180
106CSNK1E0.58867192
107NME10.58849826
108CDK150.58789636
109ATR0.57896573
110CDK180.56610956
111TRIM280.55087566
112ATM0.54739738
113PHKG10.54049871
114PHKG20.54049871
115NLK0.53839068
116CDK140.53550906
117SGK4940.52175825
118SGK2230.52175825
119INSRR0.51514779
120CHEK10.50776292
121KSR20.50591368
122TESK10.49995354
123STK110.48503604
124CCNB10.48435845
125TSSK60.47077547
126TESK20.46969403
127IRAK20.46190510
128PRKD30.45904636
129FGFR40.45670529
130DYRK1B0.45216899
131CDK10.44971570
132PRKDC0.44453953
133PRKAA10.44000155
134PRKCI0.43600189
135PKN10.43279688
136GRK10.42485608
137SIK10.42182186
138PBK0.41849197
139CDK20.41357488
140MINK10.39770453
141PDK30.39646347
142PDK40.39646347
143CDK50.39278834
144MAPK110.39124080
145MAP2K20.38982900
146MAP2K40.38685025
147PINK10.35894765
148OXSR10.35188921
149GSK3B0.32311680

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.68654350
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.93786234
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.69781097
4Cell cycle_Homo sapiens_hsa041102.63578718
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.55985809
6DNA replication_Homo sapiens_hsa030302.52294930
7Basal cell carcinoma_Homo sapiens_hsa052172.35102059
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.31043956
9Proteasome_Homo sapiens_hsa030502.19324094
10Spliceosome_Homo sapiens_hsa030402.07422927
11Butanoate metabolism_Homo sapiens_hsa006502.04244050
12Hedgehog signaling pathway_Homo sapiens_hsa043402.01949953
13Carbon metabolism_Homo sapiens_hsa012002.00273240
14RNA transport_Homo sapiens_hsa030131.98304938
15RNA polymerase_Homo sapiens_hsa030201.92847563
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.90142742
17Selenocompound metabolism_Homo sapiens_hsa004501.86424781
18Base excision repair_Homo sapiens_hsa034101.81406744
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.69264037
20Nicotine addiction_Homo sapiens_hsa050331.67958997
21Vitamin B6 metabolism_Homo sapiens_hsa007501.67223478
22Hippo signaling pathway_Homo sapiens_hsa043901.65862565
23Biosynthesis of amino acids_Homo sapiens_hsa012301.65789136
24Fatty acid degradation_Homo sapiens_hsa000711.63849013
25Pyrimidine metabolism_Homo sapiens_hsa002401.62432064
26Fatty acid metabolism_Homo sapiens_hsa012121.62289290
27Notch signaling pathway_Homo sapiens_hsa043301.61802497
28Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.59793606
29Mismatch repair_Homo sapiens_hsa034301.56955007
30One carbon pool by folate_Homo sapiens_hsa006701.54955601
31Axon guidance_Homo sapiens_hsa043601.53691557
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.51342246
33Steroid biosynthesis_Homo sapiens_hsa001001.49701716
34Non-homologous end-joining_Homo sapiens_hsa034501.46120997
35Propanoate metabolism_Homo sapiens_hsa006401.43411482
36Cardiac muscle contraction_Homo sapiens_hsa042601.35627441
37Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.28009092
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.27216793
39mRNA surveillance pathway_Homo sapiens_hsa030151.25360403
40Lysine degradation_Homo sapiens_hsa003101.24574896
41Tryptophan metabolism_Homo sapiens_hsa003801.23935846
42Maturity onset diabetes of the young_Homo sapiens_hsa049501.17357423
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.16374635
44Alzheimers disease_Homo sapiens_hsa050101.16197484
45Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.12913109
46Sulfur relay system_Homo sapiens_hsa041221.10163141
47RNA degradation_Homo sapiens_hsa030181.09037487
48Phototransduction_Homo sapiens_hsa047441.05310458
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.05294616
50Folate biosynthesis_Homo sapiens_hsa007901.01963041
51Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.99963441
52Taste transduction_Homo sapiens_hsa047420.99895591
53MicroRNAs in cancer_Homo sapiens_hsa052060.99798195
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.99300348
55Bladder cancer_Homo sapiens_hsa052190.99037687
56Oocyte meiosis_Homo sapiens_hsa041140.96017927
57Endometrial cancer_Homo sapiens_hsa052130.95561693
58Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.94681814
59Huntingtons disease_Homo sapiens_hsa050160.94185561
60Vitamin digestion and absorption_Homo sapiens_hsa049770.91894380
61Nucleotide excision repair_Homo sapiens_hsa034200.90227373
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.89673236
63Fatty acid elongation_Homo sapiens_hsa000620.89626828
64Morphine addiction_Homo sapiens_hsa050320.86362475
65Peroxisome_Homo sapiens_hsa041460.85247657
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.85177612
67Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84296781
68Parkinsons disease_Homo sapiens_hsa050120.83037701
69Pyruvate metabolism_Homo sapiens_hsa006200.82767025
70Protein export_Homo sapiens_hsa030600.81813837
71Basal transcription factors_Homo sapiens_hsa030220.81607926
72Galactose metabolism_Homo sapiens_hsa000520.81235792
73Oxidative phosphorylation_Homo sapiens_hsa001900.80633091
74GABAergic synapse_Homo sapiens_hsa047270.80110595
75Pentose phosphate pathway_Homo sapiens_hsa000300.79271049
76Arginine and proline metabolism_Homo sapiens_hsa003300.79145086
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78622848
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.78145972
79Tight junction_Homo sapiens_hsa045300.75698567
80Regulation of autophagy_Homo sapiens_hsa041400.75588573
81Homologous recombination_Homo sapiens_hsa034400.74082707
82Thyroid cancer_Homo sapiens_hsa052160.72947231
83Purine metabolism_Homo sapiens_hsa002300.71158249
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.71065042
85Glutathione metabolism_Homo sapiens_hsa004800.70590021
86Adherens junction_Homo sapiens_hsa045200.70167185
87Glutamatergic synapse_Homo sapiens_hsa047240.69462665
88PPAR signaling pathway_Homo sapiens_hsa033200.68399890
89Dilated cardiomyopathy_Homo sapiens_hsa054140.68276492
90TGF-beta signaling pathway_Homo sapiens_hsa043500.68152198
91Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.66026272
92Wnt signaling pathway_Homo sapiens_hsa043100.65576895
93Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64941108
94Alcoholism_Homo sapiens_hsa050340.64740538
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.64374930
96beta-Alanine metabolism_Homo sapiens_hsa004100.63655510
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.62959831
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61035428
99p53 signaling pathway_Homo sapiens_hsa041150.59658543
100Circadian entrainment_Homo sapiens_hsa047130.58652880
101Fructose and mannose metabolism_Homo sapiens_hsa000510.58527845
102Gap junction_Homo sapiens_hsa045400.55532745
103Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.54686133
104Cyanoamino acid metabolism_Homo sapiens_hsa004600.54648961
105Prion diseases_Homo sapiens_hsa050200.54197790
106Melanogenesis_Homo sapiens_hsa049160.53796840
107Chronic myeloid leukemia_Homo sapiens_hsa052200.52016997
108Fanconi anemia pathway_Homo sapiens_hsa034600.50657133
109Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50477136
110Dopaminergic synapse_Homo sapiens_hsa047280.50005430
111Cholinergic synapse_Homo sapiens_hsa047250.49975316
112Epstein-Barr virus infection_Homo sapiens_hsa051690.49461986
113Serotonergic synapse_Homo sapiens_hsa047260.49382087
114Insulin signaling pathway_Homo sapiens_hsa049100.49256280
115Non-small cell lung cancer_Homo sapiens_hsa052230.47557413
116Cocaine addiction_Homo sapiens_hsa050300.46776715
117Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.45617912
118Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45589593
119Colorectal cancer_Homo sapiens_hsa052100.45330656
120Phenylalanine metabolism_Homo sapiens_hsa003600.44418050
121Viral myocarditis_Homo sapiens_hsa054160.44166228
122Insulin secretion_Homo sapiens_hsa049110.43989431
123Metabolic pathways_Homo sapiens_hsa011000.43908314
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43695427
125HTLV-I infection_Homo sapiens_hsa051660.42730755
126Mineral absorption_Homo sapiens_hsa049780.41974152
127Protein digestion and absorption_Homo sapiens_hsa049740.41620546
128Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40747859
129Olfactory transduction_Homo sapiens_hsa047400.39949947
130Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.39683312
131cAMP signaling pathway_Homo sapiens_hsa040240.39179247
132Pathways in cancer_Homo sapiens_hsa052000.38167149
133Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37831109
134Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37765808
135alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36674109
136Proteoglycans in cancer_Homo sapiens_hsa052050.35840688
137Melanoma_Homo sapiens_hsa052180.34546285

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