SPRR4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1multicellular organismal water homeostasis (GO:0050891)9.89331825
2* peptide cross-linking (GO:0018149)9.07651163
3water homeostasis (GO:0030104)8.87657583
4intermediate filament organization (GO:0045109)7.77105195
5hemidesmosome assembly (GO:0031581)7.60676662
6keratinocyte differentiation (GO:0030216)7.43624769
7skin morphogenesis (GO:0043589)6.27872514
8adhesion of symbiont to host cell (GO:0044650)6.25373266
9virion attachment to host cell (GO:0019062)6.25373266
10bundle of His cell to Purkinje myocyte communication (GO:0086069)6.16158806
11long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)6.15562832
12epidermal cell differentiation (GO:0009913)6.10915649
13epidermis development (GO:0008544)6.03703697
14long-chain fatty-acyl-CoA metabolic process (GO:0035336)5.88878976
15negative regulation of T cell mediated immunity (GO:0002710)5.72684080
16very long-chain fatty acid metabolic process (GO:0000038)5.71742234
17negative regulation of type 2 immune response (GO:0002829)5.62756112
18fatty-acyl-CoA biosynthetic process (GO:0046949)5.49171825
19adhesion of symbiont to host (GO:0044406)5.08488931
20retinol metabolic process (GO:0042572)4.96546438
21glucosamine-containing compound catabolic process (GO:1901072)4.67103227
22fatty-acyl-CoA metabolic process (GO:0035337)4.62067498
23acyl-CoA biosynthetic process (GO:0071616)4.51880971
24thioester biosynthetic process (GO:0035384)4.51880971
25intermediate filament cytoskeleton organization (GO:0045104)4.51301074
26intermediate filament-based process (GO:0045103)4.35216227
27hair follicle morphogenesis (GO:0031069)4.32222312
28lipoxygenase pathway (GO:0019372)4.25717700
29embryonic viscerocranium morphogenesis (GO:0048703)4.24692078
30positive regulation of chemokine secretion (GO:0090197)4.22552279
31regulation of interleukin-13 production (GO:0032656)4.22308727
32fibrinolysis (GO:0042730)4.14038757
33hydrogen peroxide biosynthetic process (GO:0050665)4.13068246
34positive regulation of keratinocyte differentiation (GO:0045618)4.10697970
35alpha-linolenic acid metabolic process (GO:0036109)4.02368562
36long-chain fatty acid biosynthetic process (GO:0042759)4.02153062
37fatty acid elongation (GO:0030497)3.96230612
38regulation of chemokine secretion (GO:0090196)3.82219436
39keratinocyte proliferation (GO:0043616)3.77623131
40primary alcohol metabolic process (GO:0034308)3.70130942
41reactive oxygen species biosynthetic process (GO:1903409)3.67131412
42citrulline biosynthetic process (GO:0019240)3.60985724
43negative regulation of keratinocyte proliferation (GO:0010839)3.48235372
44regulation of T cell cytokine production (GO:0002724)3.46418103
45defense response to fungus (GO:0050832)3.38439774
46positive regulation of epidermal cell differentiation (GO:0045606)3.34401096
47keratinocyte development (GO:0003334)3.29272996
48triglyceride biosynthetic process (GO:0019432)3.29139702
49negative regulation of lymphocyte mediated immunity (GO:0002707)3.27247245
50molting cycle process (GO:0022404)3.26270241
51hair cycle process (GO:0022405)3.26270241
52negative regulation of cytokine production involved in immune response (GO:0002719)3.22462383
53regulation of hair follicle development (GO:0051797)3.12603788
54regulation of interleukin-5 production (GO:0032674)3.10670160
55acylglycerol biosynthetic process (GO:0046463)3.10295069
56neutral lipid biosynthetic process (GO:0046460)3.10295069
57retina homeostasis (GO:0001895)3.05762308
58epithelial cell differentiation involved in prostate gland development (GO:0060742)3.03843108
59regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)3.03711027
60phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.00190676
61killing of cells of other organism (GO:0031640)2.99023314
62disruption of cells of other organism (GO:0044364)2.99023314
63negative regulation of erythrocyte differentiation (GO:0045647)2.98475194
64epithelium development (GO:0060429)2.98302254
65cell wall macromolecule catabolic process (GO:0016998)2.96775104
66cell wall macromolecule metabolic process (GO:0044036)2.96775104
67regulation of sequestering of triglyceride (GO:0010889)2.96108369
68positive regulation of epidermis development (GO:0045684)2.95113496
69phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.91260632
70skin development (GO:0043588)2.90288682
71lateral sprouting from an epithelium (GO:0060601)2.89637988
72determination of adult lifespan (GO:0008340)2.89548146
73negative regulation of cell fate specification (GO:0009996)2.89271692
74response to phenylpropanoid (GO:0080184)2.86872377
75ephrin receptor signaling pathway (GO:0048013)2.85924149
76positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.84176676
77sphingosine metabolic process (GO:0006670)2.83937198
78cellular response to calcium ion (GO:0071277)2.83731419
79regulation of ruffle assembly (GO:1900027)2.79442140
80ectoderm development (GO:0007398)2.78093764
81primary alcohol catabolic process (GO:0034310)2.78090937
82phosphatidylinositol acyl-chain remodeling (GO:0036149)2.77959401
83regulation of hair cycle (GO:0042634)2.77934935
84positive regulation of monocyte chemotaxis (GO:0090026)2.77356903
85thyroid hormone generation (GO:0006590)2.77159537
86linoleic acid metabolic process (GO:0043651)2.76789900
87carnitine metabolic process (GO:0009437)2.75904459
88phosphatidylcholine acyl-chain remodeling (GO:0036151)2.74353531
89phosphatidylserine acyl-chain remodeling (GO:0036150)2.72758038
90one-carbon compound transport (GO:0019755)2.71918974
91growth hormone secretion (GO:0030252)2.69926812
92regulation of type 2 immune response (GO:0002828)2.68339120
93thioester metabolic process (GO:0035383)2.66138298
94acyl-CoA metabolic process (GO:0006637)2.66138298
95sphingoid metabolic process (GO:0046519)2.64947255
96cardiac epithelial to mesenchymal transition (GO:0060317)2.64795765
97fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.63492662
98ventricular cardiac muscle cell action potential (GO:0086005)2.55040946
99detection of bacterium (GO:0016045)2.52702923
100pharyngeal system development (GO:0060037)2.52349876
101negative regulation of production of molecular mediator of immune response (GO:0002701)2.52000507
102segment specification (GO:0007379)2.51866800
103diol metabolic process (GO:0034311)2.51575914
104negative regulation of viral entry into host cell (GO:0046597)2.50620177
105unsaturated fatty acid biosynthetic process (GO:0006636)2.47327565
106phosphatidylserine metabolic process (GO:0006658)2.47064751
107positive regulation of hair cycle (GO:0042635)2.46657859
108positive regulation of hair follicle development (GO:0051798)2.46657859
109establishment of tissue polarity (GO:0007164)2.45803830
110establishment of planar polarity (GO:0001736)2.45803830
111regulation of endothelial cell chemotaxis (GO:2001026)2.43887220
112middle ear morphogenesis (GO:0042474)2.42936294
113hair follicle development (GO:0001942)2.42604211
114regulation of keratinocyte differentiation (GO:0045616)2.42222465
115polarized epithelial cell differentiation (GO:0030859)2.40760748
116regulation of monocyte chemotaxis (GO:0090025)2.40396905
117regulation of cardioblast differentiation (GO:0051890)2.40305263
118superoxide anion generation (GO:0042554)2.39403735
119eyelid development in camera-type eye (GO:0061029)2.39225007
120planar cell polarity pathway involved in neural tube closure (GO:0090179)2.38867581
121positive regulation of Cdc42 GTPase activity (GO:0043089)2.37639527
122regulation of epidermal cell differentiation (GO:0045604)2.34727702
123positive regulation of granulocyte chemotaxis (GO:0071624)2.34005954
124thyroid hormone metabolic process (GO:0042403)2.33990220
125regulation of transforming growth factor beta2 production (GO:0032909)2.31674583
126atrioventricular valve morphogenesis (GO:0003181)2.30618058
127osteoblast development (GO:0002076)2.28981535
128heart valve morphogenesis (GO:0003179)2.28778863
129positive regulation of growth hormone secretion (GO:0060124)2.28175891
130cell-substrate junction assembly (GO:0007044)2.28066446
131regulation of defense response to virus by host (GO:0050691)2.27864965
132negative regulation of dendrite morphogenesis (GO:0050774)2.27611518
133negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.26606211
134detection of other organism (GO:0098543)2.26586193
135positive regulation of cholesterol efflux (GO:0010875)2.25968116
136fatty acid biosynthetic process (GO:0006633)2.25107224
137tooth mineralization (GO:0034505)2.25089397
138hydrogen peroxide catabolic process (GO:0042744)2.23291754
139positive regulation of vesicle fusion (GO:0031340)2.22553348
140ethanol metabolic process (GO:0006067)2.20199178
141gap junction assembly (GO:0016264)2.12798575
142response to fungus (GO:0009620)2.09721109
143regulation of keratinocyte proliferation (GO:0010837)2.06562106
144regulation of epidermis development (GO:0045682)2.05526212
145regulation of phospholipase A2 activity (GO:0032429)2.04451640
146alditol phosphate metabolic process (GO:0052646)2.04208907
147* keratinization (GO:0031424)18.9537224
148establishment of skin barrier (GO:0061436)17.5306595
149hair cycle (GO:0042633)17.1191972
150molting cycle (GO:0042303)17.1191972
151regulation of water loss via skin (GO:0033561)15.0289648
152desmosome organization (GO:0002934)12.6144318
153phosphatidic acid biosynthetic process (GO:0006654)1.98439646
154phosphatidic acid metabolic process (GO:0046473)1.98439646
155regulation of natural killer cell differentiation (GO:0032823)1.92655300
156positive regulation of macrophage derived foam cell differentiation (GO:0010744)1.91167932
157negative regulation of execution phase of apoptosis (GO:1900118)1.85603444
158amino-acid betaine metabolic process (GO:0006577)1.78411050
159ceramide biosynthetic process (GO:0046513)1.78080341
160phospholipid catabolic process (GO:0009395)1.76299568

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* P63_26484246_Chip-Seq_KERATINOCYTES_Human3.36638074
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.18091105
3SOX9_24532713_ChIP-Seq_HFSC_Mouse2.70327709
4ESR1_21235772_ChIP-Seq_MCF-7_Human2.42471088
5CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.25256268
6SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.24858736
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.13107176
8FOXO3_23340844_ChIP-Seq_DLD1_Human2.09826197
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.03907644
10ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.02691966
11TP63_17297297_ChIP-ChIP_HaCaT_Human11.9126647
12ZNF263_19887448_ChIP-Seq_K562_Human1.89086991
13SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.75972539
14SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.75972539
15EGR1_19032775_ChIP-ChIP_M12_Human1.75864877
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.74950057
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.71748301
18CTCF_20526341_ChIP-Seq_ESCs_Human1.71464775
19SUZ12_27294783_Chip-Seq_ESCs_Mouse1.66145587
20JARID2_20075857_ChIP-Seq_MESCs_Mouse1.57607975
21* TP63_23658742_ChIP-Seq_EP156T_Human1.54585655
22* TP63_22573176_ChIP-Seq_HFKS_Human1.54472003
23TAF2_19829295_ChIP-Seq_ESCs_Human1.52031066
24CTCF_27219007_Chip-Seq_Bcells_Human1.48863971
25* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.47990034
26* ERG_20517297_ChIP-Seq_VCAP_Human1.47004332
27TP53_20018659_ChIP-ChIP_R1E_Mouse1.44122380
28HIF1A_21447827_ChIP-Seq_MCF-7_Human1.41904385
29ERG_21242973_ChIP-ChIP_JURKAT_Human1.41737955
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.39047328
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.38061405
32PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.36788631
33VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.32333702
34KLF5_25053715_ChIP-Seq_YYC3_Human1.31574381
35P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.31133504
36SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.27594803
37* GATA6_21074721_ChIP-Seq_CACO-2_Human1.26970325
38RACK7_27058665_Chip-Seq_MCF-7_Human1.25542641
39ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25203846
40EZH2_27294783_Chip-Seq_ESCs_Mouse1.25009827
41BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.24263313
42DNAJC2_21179169_ChIP-ChIP_NT2_Human1.24212982
43BCOR_27268052_Chip-Seq_Bcells_Human1.23541906
44EZH2_27304074_Chip-Seq_ESCs_Mouse1.23444285
45LXR_22292898_ChIP-Seq_THP-1_Human1.23429115
46VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.23156838
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22520754
48YY1_22570637_ChIP-Seq_MALME-3M_Human1.22213984
49BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.22192467
50TRIM28_21343339_ChIP-Seq_HEK293_Human1.21114609
51SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.17555153
52CEBPB_22108803_ChIP-Seq_LS180_Human1.17457990
53RARG_19884340_ChIP-ChIP_MEFs_Mouse1.17247092
54ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.16657221
55SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.16600783
56TCF4_18268006_ChIP-ChIP_LS174T_Human1.16251123
57RXR_22108803_ChIP-Seq_LS180_Human1.15248755
58ELK4_26923725_Chip-Seq_MESODERM_Mouse1.13305023
59SOX2_20726797_ChIP-Seq_SW620_Human1.11226344
60E2F1_20622854_ChIP-Seq_HELA_Human1.10920000
61RNF2_18974828_ChIP-Seq_MESCs_Mouse1.10071559
62EZH2_18974828_ChIP-Seq_MESCs_Mouse1.10071559
63SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.08866950
64RING1B_27294783_Chip-Seq_ESCs_Mouse1.08749036
65P53_21459846_ChIP-Seq_SAOS-2_Human1.08245362
66NANOG_20526341_ChIP-Seq_ESCs_Human1.08123290
67* RUNX1_27514584_Chip-Seq_MCF-7_Human1.07666274
68CSB_26484114_Chip-Seq_FIBROBLAST_Human1.07528686
69GATA3_24758297_ChIP-Seq_MCF-7_Human1.07394495
70UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.07078314
71RNF2_27304074_Chip-Seq_ESCs_Mouse1.05490899
72BCAT_22108803_ChIP-Seq_LS180_Human1.05173080
73SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.05069121
74EED_16625203_ChIP-ChIP_MESCs_Mouse1.03661424
75ATF3_27146783_Chip-Seq_COLON_Human1.03427039
76ESR1_20079471_ChIP-ChIP_T-47D_Human1.01362353
77JARID2_20064375_ChIP-Seq_MESCs_Mouse1.00569384
78SA1_27219007_Chip-Seq_ERYTHROID_Human0.99342829
79TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99114965
80UBF1/2_26484160_Chip-Seq_HMECs_Human0.98710272
81EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.98276607
82AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96616910
83AR_21572438_ChIP-Seq_LNCaP_Human0.95549418
84TP53_18474530_ChIP-ChIP_U2OS_Human0.95538365
85BCL6_27268052_Chip-Seq_Bcells_Human0.93335467
86MTF2_20144788_ChIP-Seq_MESCs_Mouse0.92818428
87AHR_22903824_ChIP-Seq_MCF-7_Human0.92750254
88TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92708344
89GATA4_25053715_ChIP-Seq_YYC3_Human0.92488858
90CJUN_26792858_Chip-Seq_BT549_Human0.92411731
91SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.92187839
92FOXA1_25329375_ChIP-Seq_VCAP_Human0.91148365
93FOXA1_27270436_Chip-Seq_PROSTATE_Human0.91148365
94ARNT_22903824_ChIP-Seq_MCF-7_Human0.91108425
95AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.89750205
96KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.89363168
97MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.88828461
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87483242
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.87483242
100P68_20966046_ChIP-Seq_HELA_Human0.87125437
101RXRA_24833708_ChIP-Seq_LIVER_Mouse0.86498651
102ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.84085823
103SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.84006356
104* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.83996418
105CDX2_19796622_ChIP-Seq_MESCs_Mouse0.83830792
106FOXH1_21741376_ChIP-Seq_ESCs_Human0.82362008
107HTT_18923047_ChIP-ChIP_STHdh_Human0.82332531
108TBX20_22080862_ChIP-Seq_HEART_Mouse0.82062693
109TBX20_22328084_ChIP-Seq_HEART_Mouse0.82062693
110NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.81949268
111BMI1_23680149_ChIP-Seq_NPCS_Mouse0.81502339
112KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.80763406
113NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.80172337
114FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.80147775
115SMAD4_21741376_ChIP-Seq_ESCs_Human0.80051766
116* SMC4_20622854_ChIP-Seq_HELA_Human0.79923829
117CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.79619530
118SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.79544889
119PHF8_20622854_ChIP-Seq_HELA_Human0.79018094
120RBPJ_21746931_ChIP-Seq_IB4_Human0.76744351
121P300_27268052_Chip-Seq_Bcells_Human0.72576521
122ELF1_20517297_ChIP-Seq_JURKAT_Human0.71918146
123SOX2_27498859_Chip-Seq_STOMACH_Mouse0.71714024
124* HNFA_21074721_ChIP-Seq_CACO-2_Human0.70222430
125SMAD3_21741376_ChIP-Seq_ESCs_Human0.69328497
126FOXH1_21741376_ChIP-Seq_EPCs_Human0.68256319
127TBL1_22424771_ChIP-Seq_293T_Human0.65770854
128PPARA_22158963_ChIP-Seq_LIVER_Mouse0.65310804
129OCT4_20526341_ChIP-Seq_ESCs_Human0.62784918
130KAP1_27257070_Chip-Seq_ESCs_Mouse0.62472485
131MYC_19829295_ChIP-Seq_ESCs_Human0.62344375
132ERA_21632823_ChIP-Seq_H3396_Human0.61787554

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier8.21556725
2MP0005275_abnormal_skin_tensile6.93663730
3MP0000579_abnormal_nail_morphology5.27454839
4MP0005501_abnormal_skin_physiology5.11106894
5MP0000647_abnormal_sebaceous_gland4.25459459
6MP0003705_abnormal_hypodermis_morpholog4.13431946
7MP0010234_abnormal_vibrissa_follicle3.86842348
8MP0002098_abnormal_vibrissa_morphology3.78150825
9MP0002254_reproductive_system_inflammat3.70121998
10MP0001188_hyperpigmentation3.60658590
11MP0000383_abnormal_hair_follicle3.36925736
12MP0000427_abnormal_hair_cycle3.27760011
13MP0004947_skin_inflammation3.16678147
14MP0001216_abnormal_epidermal_layer3.13332256
15MP0002060_abnormal_skin_morphology3.00488770
16MP0010771_integument_phenotype2.99797370
17MP0000377_abnormal_hair_follicle2.90499135
18MP0010678_abnormal_skin_adnexa2.90424877
19MP0005075_abnormal_melanosome_morpholog2.57674894
20MP0005451_abnormal_body_composition2.36702179
21MP0004381_abnormal_hair_follicle2.31927024
22MP0005377_hearing/vestibular/ear_phenot2.20520653
23MP0003878_abnormal_ear_physiology2.20520653
24MP0003453_abnormal_keratinocyte_physiol2.11690888
25MP0000762_abnormal_tongue_morphology2.01940434
26MP0003941_abnormal_skin_development1.86688673
27MP0001243_abnormal_dermal_layer1.82884949
28MP0003566_abnormal_cell_adhesion1.78010548
29MP0000367_abnormal_coat/_hair1.73546856
30MP0009931_abnormal_skin_appearance1.70455904
31MP0002102_abnormal_ear_morphology1.68353230
32MP0002095_abnormal_skin_pigmentation1.48275095
33MP0000467_abnormal_esophagus_morphology1.45058072
34MP0001346_abnormal_lacrimal_gland1.40061852
35MP0003300_gastrointestinal_ulcer1.35296629
36MP0001191_abnormal_skin_condition1.34955708
37MP0002177_abnormal_outer_ear1.28640784
38MP0010030_abnormal_orbit_morphology1.24674165
39MP0002234_abnormal_pharynx_morphology1.21353080
40MP0001851_eye_inflammation1.18463386
41MP0004185_abnormal_adipocyte_glucose1.11246817
42MP0005647_abnormal_sex_gland1.06905763
43MP0000015_abnormal_ear_pigmentation1.03954695
44MP0005174_abnormal_tail_pigmentation1.02953514
45MP0005409_darkened_coat_color0.93860010
46MP0001661_extended_life_span0.93683447
47MP0001340_abnormal_eyelid_morphology0.82470822
48MP0003950_abnormal_plasma_membrane0.75544291
49MP0003191_abnormal_cellular_cholesterol0.72825151
50MP0000465_gastrointestinal_hemorrhage0.72693560
51MP0009053_abnormal_anal_canal0.72647753
52MP0001270_distended_abdomen0.69756925
53MP0002877_abnormal_melanocyte_morpholog0.69699699
54MP0001849_ear_inflammation0.64284588
55MP0001784_abnormal_fluid_regulation0.64171464
56MP0006035_abnormal_mitochondrial_morpho0.62696221
57MP0002282_abnormal_trachea_morphology0.62608027
58MP0000013_abnormal_adipose_tissue0.60793185
59MP0004782_abnormal_surfactant_physiolog0.60316310
60MP0004019_abnormal_vitamin_homeostasis0.58156382
61MP0010352_gastrointestinal_tract_polyps0.57448770
62MP0008789_abnormal_olfactory_epithelium0.54592428
63MP0005503_abnormal_tendon_morphology0.54114496
64MP0000049_abnormal_middle_ear0.50202815
65MP0002970_abnormal_white_adipose0.49869235
66MP0003755_abnormal_palate_morphology0.48980642
67MP0001984_abnormal_olfaction0.47320608
68MP0004885_abnormal_endolymph0.47062119
69MP0002249_abnormal_larynx_morphology0.46025203
70MP0000627_abnormal_mammary_gland0.44502944
71MP0001485_abnormal_pinna_reflex0.43254809
72MP0005375_adipose_tissue_phenotype0.43139875
73MP0005248_abnormal_Harderian_gland0.41838406
74MP0009780_abnormal_chondrocyte_physiolo0.39833270
75MP0008569_lethality_at_weaning0.39107525
76MP0003638_abnormal_response/metabolism_0.38238758
77MP0000538_abnormal_urinary_bladder0.37528452
78MP0005666_abnormal_adipose_tissue0.36567517
79MP0000003_abnormal_adipose_tissue0.36175632
80MP0003011_delayed_dark_adaptation0.35754926
81MP0005257_abnormal_intraocular_pressure0.34566948
82MP0004742_abnormal_vestibular_system0.33863800
83MP0001299_abnormal_eye_distance/0.33732265
84MP0005508_abnormal_skeleton_morphology0.32359716
85MP0000428_abnormal_craniofacial_morphol0.30840333
86MP0002111_abnormal_tail_morphology0.30696966
87MP0005023_abnormal_wound_healing0.30532799
88MP0002009_preneoplasia0.29296117
89MP0009379_abnormal_foot_pigmentation0.28763161
90MP0002697_abnormal_eye_size0.28139660
91MP0005535_abnormal_body_temperature0.28031217
92MP0009384_cardiac_valve_regurgitation0.26138364
93MP0000566_synostosis0.25913077
94MP0005394_taste/olfaction_phenotype0.25404984
95MP0005499_abnormal_olfactory_system0.25404984
96MP0003183_abnormal_peptide_metabolism0.25176015
97MP0002896_abnormal_bone_mineralization0.24421741
98MP0001186_pigmentation_phenotype0.24252850
99MP0003632_abnormal_nervous_system0.23777097
100MP0002972_abnormal_cardiac_muscle0.23474510
101MP0003763_abnormal_thymus_physiology0.22733347
102MP0009333_abnormal_splenocyte_physiolog0.21620249
103MP0001348_abnormal_lacrimal_gland0.21501494
104MP0005193_abnormal_anterior_eye0.20878125
105MP0003959_abnormal_lean_body0.19678267
106MP0008438_abnormal_cutaneous_collagen0.19630992
107MP0001177_atelectasis0.18321938
108MP0003448_altered_tumor_morphology0.18125232
109MP0004264_abnormal_extraembryonic_tissu0.17983101
110MP0002090_abnormal_vision0.17635070
111MP0002277_abnormal_respiratory_mucosa0.17139281
112MP0000604_amyloidosis0.16965204
113MP0001501_abnormal_sleep_pattern0.16906083
114MP0000462_abnormal_digestive_system0.16792279
115MP0004858_abnormal_nervous_system0.16305688
116MP0003329_amyloid_beta_deposits0.15789752
117MP0003385_abnormal_body_wall0.14400600
118MP0002971_abnormal_brown_adipose0.12763937
119MP0001919_abnormal_reproductive_system0.12255342
120MP0000685_abnormal_immune_system0.09893421
121MP0002163_abnormal_gland_morphology0.09375046
122MP0002166_altered_tumor_susceptibility0.07665382
123MP0003646_muscle_fatigue0.07604213
124MP0001958_emphysema0.07347800
125MP0000751_myopathy0.07083722
126MP0006138_congestive_heart_failure0.06881978
127MP0005452_abnormal_adipose_tissue0.04684686
128MP0002006_tumorigenesis0.04008304
129MP0002108_abnormal_muscle_morphology0.02790040
130MP0005379_endocrine/exocrine_gland_phen0.02507576
131MP0002118_abnormal_lipid_homeostasis0.01500549
132MP0002133_abnormal_respiratory_system0.00930646
133MP0005388_respiratory_system_phenotype0.00930646
134MP0001666_abnormal_nutrient_absorption0.00810847
135MP0009703_decreased_birth_body0.00734676
136MP0005646_abnormal_pituitary_gland0.00707483
137MP0001756_abnormal_urination-0.0004918

Predicted human phenotypes

RankGene SetZ-score
1Conjunctival hamartoma (HP:0100780)8.52832212
2Erythema (HP:0010783)8.02259393
3Woolly hair (HP:0002224)7.95309199
4Pili torti (HP:0003777)7.68979132
5Palmoplantar hyperkeratosis (HP:0000972)7.11175345
6Plantar hyperkeratosis (HP:0007556)7.03519355
7Palmar hyperkeratosis (HP:0010765)6.70174358
8Onycholysis (HP:0001806)6.64575927
9Erythroderma (HP:0001019)6.60491728
10Absent eyelashes (HP:0000561)6.30301030
11Hamartoma of the eye (HP:0010568)5.98885530
12Abnormality of nail color (HP:0100643)5.78497238
13Fragile nails (HP:0001808)5.51664507
14Abnormal hair laboratory examination (HP:0003328)5.08939547
15Abnormality of the axillary hair (HP:0100134)4.90291699
16Abnormality of secondary sexual hair (HP:0009888)4.90291699
17Eczematoid dermatitis (HP:0000976)4.89099479
18Nail dystrophy (HP:0008404)4.84586898
19Right ventricular cardiomyopathy (HP:0011663)4.81417786
20Absent eyebrow (HP:0002223)4.81113017
21Absent hair (HP:0002298)4.73354718
22Brittle hair (HP:0002299)4.67293405
23Abnormality of hair growth rate (HP:0011363)4.59767070
24Slow-growing hair (HP:0002217)4.59767070
25Abnormal blistering of the skin (HP:0008066)4.49676022
26Milia (HP:0001056)4.13598521
27Gangrene (HP:0100758)4.06873179
28Congenital ichthyosiform erythroderma (HP:0007431)4.01409263
29Thick nail (HP:0001805)3.98345744
30Sparse eyelashes (HP:0000653)3.55732123
31Alopecia of scalp (HP:0002293)3.31325751
32Follicular hyperkeratosis (HP:0007502)3.24607543
33Hypergammaglobulinemia (HP:0010702)3.03028350
34Distal lower limb muscle weakness (HP:0009053)2.99294064
35Hyporeflexia of lower limbs (HP:0002600)2.99259635
36Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.91716354
37Palmoplantar keratoderma (HP:0000982)2.90080264
38Natal tooth (HP:0000695)2.89264540
39Corneal erosion (HP:0200020)2.88953913
40Double outlet right ventricle (HP:0001719)2.88765512
41Congenital malformation of the right heart (HP:0011723)2.88765512
42Hamartoma (HP:0010566)2.85793277
43Advanced eruption of teeth (HP:0006288)2.83659354
44Curly hair (HP:0002212)2.71425690
45Abnormality of the pupil (HP:0000615)2.68071615
46Ectropion (HP:0000656)2.61275199
47Ridged nail (HP:0001807)2.49149046
48Hypohidrosis (HP:0000966)2.47045698
49Ventricular tachycardia (HP:0004756)2.44275559
50Pruritus (HP:0000989)2.43099070
51Atrophic scars (HP:0001075)2.40331429
52Fine hair (HP:0002213)2.30537586
53Oral leukoplakia (HP:0002745)2.30533282
54Parakeratosis (HP:0001036)2.27809287
55Aplasia cutis congenita (HP:0001057)2.27685564
56Lip pit (HP:0100267)2.24994854
57Amelogenesis imperfecta (HP:0000705)2.19359719
58Melanocytic nevus (HP:0000995)2.17741360
59Verrucae (HP:0200043)2.14379268
60Papilloma (HP:0012740)2.14379268
61Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.03616120
62Increased IgE level (HP:0003212)10.4813734
63Hypotrichosis (HP:0001006)10.1135534
64Concave nail (HP:0001598)1.99867041
65Congenital, generalized hypertrichosis (HP:0004540)1.96218532
66Coarse hair (HP:0002208)1.94817304
67Abnormality of the salivary glands (HP:0010286)1.89136796
68Skin ulcer (HP:0200042)1.88504165
69Ventricular fibrillation (HP:0001663)1.86129784
70Mixed hearing impairment (HP:0000410)1.85342929
71Blepharitis (HP:0000498)1.79036073
72Hyperhidrosis (HP:0000975)1.78529530
73Abnormality of permanent molar morphology (HP:0011071)1.69009562
74Abnormality of the dental root (HP:0006486)1.69009562
75Taurodontia (HP:0000679)1.69009562
76Xerostomia (HP:0000217)1.66474697
77Achilles tendon contracture (HP:0001771)1.65668588
78Areflexia of lower limbs (HP:0002522)1.64222870
79Urticaria (HP:0001025)1.59391184
80Intention tremor (HP:0002080)1.59310687
81Abnormality of molar (HP:0011077)1.58347152
82Abnormality of molar morphology (HP:0011070)1.58347152
83Abnormality of the Achilles tendon (HP:0005109)1.56264717
84Lack of skin elasticity (HP:0100679)1.53683004
85Abnormality of the fingernails (HP:0001231)1.53400786
86Septate vagina (HP:0001153)1.52037427
87Abnormality of the dental pulp (HP:0006479)1.51699376
88Furrowed tongue (HP:0000221)1.48155645
89Acanthosis nigricans (HP:0000956)1.47001083
90Increased connective tissue (HP:0009025)1.46508143
91Anonychia (HP:0001798)1.45963284
92Abnormality of the neuromuscular junction (HP:0003398)1.44460977
93Fatigable weakness (HP:0003473)1.44460977
94Split foot (HP:0001839)1.43674088
95Dry hair (HP:0011359)1.41352199
96Down-sloping shoulders (HP:0200021)1.40900725
97Nasolacrimal duct obstruction (HP:0000579)1.40728914
98Neck muscle weakness (HP:0000467)1.39233183
99Difficulty walking (HP:0002355)1.38111007
100Sudden death (HP:0001699)1.36868906
101Abnormality of the gastric mucosa (HP:0004295)1.36632779
102Type 1 muscle fiber predominance (HP:0003803)1.36406752
103Truncus arteriosus (HP:0001660)1.35551936
104Conical tooth (HP:0000698)1.35176872
105Carious teeth (HP:0000670)1.34917516
106Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.33769335
107Hypoplastic labia majora (HP:0000059)1.33443721
108Keratoconjunctivitis (HP:0001096)1.31640767
109Abnormality of the frontal sinuses (HP:0002687)1.30786324
110Ulnar claw (HP:0001178)1.29612730
111Abnormality of calcium-phosphate metabolism (HP:0100530)1.29296202
112Asthma (HP:0002099)1.28971170
113Round ear (HP:0100830)1.28899970
114Multifactorial inheritance (HP:0001426)1.26755771
115Sparse scalp hair (HP:0002209)1.24896795
116Selective tooth agenesis (HP:0001592)1.24228243
117Sensory axonal neuropathy (HP:0003390)1.23545827
118Neonatal death (HP:0003811)1.21560991
119Distal lower limb amyotrophy (HP:0008944)1.20577672
120Aplasia involving bones of the extremities (HP:0009825)1.19772109
121Aplasia involving bones of the upper limbs (HP:0009823)1.19772109
122Aplasia of the phalanges of the hand (HP:0009802)1.19772109
123Abnormality of the labia majora (HP:0012881)1.19693787
124Dry skin (HP:0000958)1.17668133
125Depressed nasal tip (HP:0000437)1.12372774
126Laryngomalacia (HP:0001601)1.11158408
127Recurrent corneal erosions (HP:0000495)1.09395836
128Craniofacial hyperostosis (HP:0004493)1.08481251
129Abnormality of the lacrimal duct (HP:0011481)1.06362823
130Oligodontia (HP:0000677)1.06087820
131Dehydration (HP:0001944)1.01017370
132Neonatal short-limb short stature (HP:0008921)1.00679251
133Duplicated collecting system (HP:0000081)1.00551439
134Generalized hyperpigmentation (HP:0007440)0.99331737
135Breast hypoplasia (HP:0003187)0.96061926

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR15.40427531
2MAPKAPK35.00809406
3FER3.82102377
4FGFR13.04126530
5EPHB12.93934955
6RPS6KB22.79786923
7TIE12.74966221
8ERN12.72644591
9CSNK1G22.65240462
10EPHB22.62798854
11PRPF4B2.37318739
12MST1R2.20478360
13TNIK2.09612005
14TAOK11.95252498
15BCR1.93794834
16MAP3K31.82389463
17STK391.82301156
18PRKD11.79930719
19SIK11.78278904
20PTK61.72146052
21MYLK1.70672437
22MAP3K61.70369894
23TTN1.60711686
24MAPK71.58475920
25PBK1.47887971
26MAP3K21.44819416
27DYRK1B1.44198865
28CDK121.44139158
29PRKCI1.42781762
30SIK31.37898589
31MAP2K61.37295947
32PIK3CG1.36325218
33MAPKAPK51.34852621
34LATS11.31539893
35TRIB31.31100792
36EPHA31.28933536
37LMTK21.27340647
38LRRK21.24789343
39MET1.24212230
40SIK21.22578509
41EPHA21.22150623
42MAPKAPK21.21697044
43MAP3K91.21624609
44MAP3K111.16922510
45PIM21.16482566
46STK241.16021015
47LATS21.14209118
48EEF2K1.10706303
49NTRK11.08074779
50NLK1.07487642
51RPS6KB11.02450814
52CAMKK11.01545692
53MAP2K41.01267649
54BLK0.99219152
55MARK30.94431762
56BTK0.86822045
57MAP3K10.86586394
58SGK4940.85538331
59SGK2230.85538331
60STK38L0.85106621
61FGFR40.83631867
62CDK60.80781503
63OXSR10.79225688
64MAP2K10.78634316
65SMG10.78374894
66HCK0.78073154
67FGFR30.76060315
68BRD40.74764722
69TESK10.72841472
70SGK20.72693537
71PRKAA20.71880586
72NTRK20.64259865
73TYK20.64121779
74BMX0.63186277
75PAK60.62703341
76MAP2K20.62130656
77ITK0.62062418
78KSR20.61768833
79DYRK30.60835120
80BCKDK0.60576378
81ERBB30.60562199
82SGK30.60357444
83PINK10.60349097
84NEK60.59266313
85IKBKB0.58692018
86MAP3K120.56989569
87GRK60.56066563
88GSK3A0.55933565
89KIT0.54696812
90STK380.53556539
91PDGFRA0.53282997
92PAK40.51947712
93PAK30.51646762
94PDK20.50813588
95ROCK10.50792916
96MATK0.49782608
97MAP3K70.48485082
98TRPM70.48422243
99PLK40.48133438
100PTK20.47625569
101PKN20.46495040
102STK30.45200395
103EPHA40.44700765
104MAP2K30.43863743
105MAPK120.43731341
106RPS6KA40.42976002
107FGFR20.42857968
108INSRR0.41926940
109MAPK40.40501233
110ABL20.40337040
111CDC42BPA0.36463089
112HIPK20.36376946
113SGK10.36343054
114MARK20.36200412
115RET0.35889815
116STK110.35594681
117ILK0.35477541
118FGR0.35024054
119ERBB20.34842728
120OBSCN0.34480524
121RIPK10.33669539
122MINK10.33397893
123CDK70.32950743
124MTOR0.32642712
125NME10.32350461
126FYN0.31614961
127CSK0.31551941
128PRKACA0.31401911
129IRAK10.31090242
130TYRO30.30850918
131RPS6KA10.30403035
132RPS6KA20.29653895
133DMPK0.29387774
134CDK30.28993117
135MAPK90.27933441
136PRKD20.27178362
137PRKD30.27032292
138DDR20.26618288
139PDPK10.25450743
140SRC0.23537785
141WNK10.23508304
142PAK20.23046180
143LIMK10.22622133
144CSNK1G10.22589718
145ADRBK10.20363487

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin digestion and absorption_Homo sapiens_hsa049773.90706803
2Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.74828424
3Fatty acid biosynthesis_Homo sapiens_hsa000613.41830462
4Autoimmune thyroid disease_Homo sapiens_hsa053203.41466173
5Linoleic acid metabolism_Homo sapiens_hsa005913.18811199
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.10314145
7Fatty acid elongation_Homo sapiens_hsa000622.62686743
8Fatty acid metabolism_Homo sapiens_hsa012122.38692772
9Cyanoamino acid metabolism_Homo sapiens_hsa004601.86038936
10Staphylococcus aureus infection_Homo sapiens_hsa051501.76192074
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.72901215
12VEGF signaling pathway_Homo sapiens_hsa043701.71703856
13Ether lipid metabolism_Homo sapiens_hsa005651.68542163
14Phenylalanine metabolism_Homo sapiens_hsa003601.65032768
15Arachidonic acid metabolism_Homo sapiens_hsa005901.64803614
16Steroid biosynthesis_Homo sapiens_hsa001001.56992302
17Phototransduction_Homo sapiens_hsa047441.55635443
18Dorso-ventral axis formation_Homo sapiens_hsa043201.47884671
19Histidine metabolism_Homo sapiens_hsa003401.47514232
20Glycerolipid metabolism_Homo sapiens_hsa005611.46667442
21Fat digestion and absorption_Homo sapiens_hsa049751.46038923
22Regulation of autophagy_Homo sapiens_hsa041401.44670460
23Axon guidance_Homo sapiens_hsa043601.42151801
24GnRH signaling pathway_Homo sapiens_hsa049121.41792401
25Arginine biosynthesis_Homo sapiens_hsa002201.41540722
26beta-Alanine metabolism_Homo sapiens_hsa004101.39761085
27Tyrosine metabolism_Homo sapiens_hsa003501.38531928
28Sphingolipid metabolism_Homo sapiens_hsa006001.38141483
29Basal cell carcinoma_Homo sapiens_hsa052171.31858382
30Tuberculosis_Homo sapiens_hsa051521.22640287
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.19552670
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.16751746
33Melanogenesis_Homo sapiens_hsa049161.15412863
34Amoebiasis_Homo sapiens_hsa051461.14746994
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.14539651
36Glycerophospholipid metabolism_Homo sapiens_hsa005641.10699617
37Glioma_Homo sapiens_hsa052141.09688233
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.08053336
39Pertussis_Homo sapiens_hsa051331.07412950
40Salivary secretion_Homo sapiens_hsa049701.06860041
41Long-term potentiation_Homo sapiens_hsa047201.05469011
42Tight junction_Homo sapiens_hsa045301.04039737
43Ovarian steroidogenesis_Homo sapiens_hsa049131.03104841
44Chemical carcinogenesis_Homo sapiens_hsa052041.02838292
45Gastric acid secretion_Homo sapiens_hsa049711.02398852
46Vascular smooth muscle contraction_Homo sapiens_hsa042701.01703069
47Adherens junction_Homo sapiens_hsa045201.01244184
48Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.99914624
49RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.99062533
50ECM-receptor interaction_Homo sapiens_hsa045120.98843737
51Renin secretion_Homo sapiens_hsa049240.96657664
52Ras signaling pathway_Homo sapiens_hsa040140.96469542
53Hepatitis C_Homo sapiens_hsa051600.96281701
54Olfactory transduction_Homo sapiens_hsa047400.90846674
55Sphingolipid signaling pathway_Homo sapiens_hsa040710.87652300
56Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86181814
57Hippo signaling pathway_Homo sapiens_hsa043900.84558023
58Proteoglycans in cancer_Homo sapiens_hsa052050.83086601
59Toll-like receptor signaling pathway_Homo sapiens_hsa046200.82813740
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.80763610
61Fatty acid degradation_Homo sapiens_hsa000710.78188244
62Rap1 signaling pathway_Homo sapiens_hsa040150.77932391
63ABC transporters_Homo sapiens_hsa020100.76850721
64Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.75179215
65PPAR signaling pathway_Homo sapiens_hsa033200.74828413
66Long-term depression_Homo sapiens_hsa047300.73902913
67Salmonella infection_Homo sapiens_hsa051320.73630397
682-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.73552050
69Collecting duct acid secretion_Homo sapiens_hsa049660.71952142
70Amphetamine addiction_Homo sapiens_hsa050310.70997788
71Retinol metabolism_Homo sapiens_hsa008300.70314096
72Estrogen signaling pathway_Homo sapiens_hsa049150.67363466
73Bladder cancer_Homo sapiens_hsa052190.66665371
74Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.65082496
75Aldosterone synthesis and secretion_Homo sapiens_hsa049250.64514962
76Hedgehog signaling pathway_Homo sapiens_hsa043400.64118660
77Acute myeloid leukemia_Homo sapiens_hsa052210.63639002
78Oxytocin signaling pathway_Homo sapiens_hsa049210.63084298
79Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.61366110
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.60530427
81Platelet activation_Homo sapiens_hsa046110.60039729
82Protein digestion and absorption_Homo sapiens_hsa049740.58137278
83Pancreatic secretion_Homo sapiens_hsa049720.57306864
84Lysosome_Homo sapiens_hsa041420.57027521
85Peroxisome_Homo sapiens_hsa041460.56674067
86Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.56538372
87Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.55014129
88Circadian entrainment_Homo sapiens_hsa047130.53206438
89Wnt signaling pathway_Homo sapiens_hsa043100.52056258
90Calcium signaling pathway_Homo sapiens_hsa040200.51371745
91Thyroid cancer_Homo sapiens_hsa052160.50372704
92Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50229252
93Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.49514673
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.49068622
95AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47837988
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.47147228
97Melanoma_Homo sapiens_hsa052180.46507420
98Steroid hormone biosynthesis_Homo sapiens_hsa001400.46416752
99Renin-angiotensin system_Homo sapiens_hsa046140.46239750
100Jak-STAT signaling pathway_Homo sapiens_hsa046300.45489044
101Focal adhesion_Homo sapiens_hsa045100.44107713
102Toxoplasmosis_Homo sapiens_hsa051450.44041231
103MicroRNAs in cancer_Homo sapiens_hsa052060.43768794
104Dilated cardiomyopathy_Homo sapiens_hsa054140.43002939
105Asthma_Homo sapiens_hsa053100.42654810
106Serotonergic synapse_Homo sapiens_hsa047260.42630357
107Pyruvate metabolism_Homo sapiens_hsa006200.42529655
108Mineral absorption_Homo sapiens_hsa049780.42509356
109Choline metabolism in cancer_Homo sapiens_hsa052310.42102201
110PI3K-Akt signaling pathway_Homo sapiens_hsa041510.41819378
111ErbB signaling pathway_Homo sapiens_hsa040120.41482312
112Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.40740595
113Primary bile acid biosynthesis_Homo sapiens_hsa001200.40501141
114Circadian rhythm_Homo sapiens_hsa047100.40238997
115Nitrogen metabolism_Homo sapiens_hsa009100.39989661
116Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38267439
117Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38085468
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37627573
119Ribosome_Homo sapiens_hsa030100.37277244
120Glucagon signaling pathway_Homo sapiens_hsa049220.36482166
121Bile secretion_Homo sapiens_hsa049760.35841303
122Gap junction_Homo sapiens_hsa045400.35300088
123Neurotrophin signaling pathway_Homo sapiens_hsa047220.31356310
124Insulin signaling pathway_Homo sapiens_hsa049100.29014181
125Phospholipase D signaling pathway_Homo sapiens_hsa040720.24064197
126Malaria_Homo sapiens_hsa051440.22098498
127Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.21974127
128Notch signaling pathway_Homo sapiens_hsa043300.21738711
129Glutamatergic synapse_Homo sapiens_hsa047240.18029539
130Butanoate metabolism_Homo sapiens_hsa006500.16636718
131Inositol phosphate metabolism_Homo sapiens_hsa005620.15554956
132NOD-like receptor signaling pathway_Homo sapiens_hsa046210.15016643
133Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.14272565
134Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.12754250

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