SPRR2F

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* keratinization (GO:0031424)9.84886448
2citrulline metabolic process (GO:0000052)9.56189502
3long-chain fatty acid biosynthetic process (GO:0042759)8.95631716
4interferon-gamma secretion (GO:0072643)8.55731904
5negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)8.49663649
6multicellular organismal water homeostasis (GO:0050891)8.03608418
7lipoxygenase pathway (GO:0019372)7.97510385
8peptidyl-arginine modification (GO:0018195)7.75337008
9maintenance of gastrointestinal epithelium (GO:0030277)7.69931655
10hair cycle (GO:0042633)7.62539353
11molting cycle (GO:0042303)7.62539353
12detection of other organism (GO:0098543)7.54737898
13sequestering of metal ion (GO:0051238)7.51876613
14positive regulation of osteoblast proliferation (GO:0033690)7.32785565
15linoleic acid metabolic process (GO:0043651)7.03734767
16lung lobe morphogenesis (GO:0060463)6.91865742
17positive regulation of monocyte chemotaxis (GO:0090026)6.87804353
18keratinocyte proliferation (GO:0043616)6.87556103
19water homeostasis (GO:0030104)6.65671284
20negative regulation of interferon-gamma production (GO:0032689)6.61916703
21complement activation, alternative pathway (GO:0006957)6.55621486
22regulation of natural killer cell differentiation (GO:0032823)6.51500675
23regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)6.44027345
24positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)6.41166096
25regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)6.41166096
26regulation of T cell chemotaxis (GO:0010819)6.35449569
27positive regulation of T cell chemotaxis (GO:0010820)6.35449569
28phosphatidylcholine acyl-chain remodeling (GO:0036151)6.26616601
29epithelial structure maintenance (GO:0010669)6.13833996
30lung vasculature development (GO:0060426)6.13248113
31gap junction assembly (GO:0016264)6.00086248
32hemidesmosome assembly (GO:0031581)5.99347266
33negative regulation of interleukin-17 production (GO:0032700)5.85132556
34regulation of toll-like receptor 4 signaling pathway (GO:0034143)5.76577725
35regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033395.69385423
364-hydroxyproline metabolic process (GO:0019471)5.62093082
37regulation of nephron tubule epithelial cell differentiation (GO:0072182)5.37830894
38* keratinocyte differentiation (GO:0030216)5.34964043
39positive regulation of astrocyte differentiation (GO:0048711)5.32264857
40positive regulation of toll-like receptor signaling pathway (GO:0034123)4.92858682
41regulation of monocyte chemotaxis (GO:0090025)4.91380453
42regulation of epithelial cell differentiation involved in kidney development (GO:2000696)4.89029432
43sulfate transmembrane transport (GO:1902358)4.88389163
44intermediate filament cytoskeleton organization (GO:0045104)4.86386754
45response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.81070959
46response to host immune response (GO:0052572)4.81070959
47intermediate filament organization (GO:0045109)4.75298067
48tyrosine phosphorylation of STAT protein (GO:0007260)4.72313488
49wound healing, spreading of epidermal cells (GO:0035313)4.69850700
50intermediate filament-based process (GO:0045103)4.69368513
51decidualization (GO:0046697)4.60646199
52ectoderm development (GO:0007398)4.58666563
53muscle organ morphogenesis (GO:0048644)4.52163032
54response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.50235075
55response to host (GO:0075136)4.50235075
56response to host defenses (GO:0052200)4.50235075
57detection of external biotic stimulus (GO:0098581)4.44289077
58phosphatidylserine acyl-chain remodeling (GO:0036150)4.42897925
59phospholipid catabolic process (GO:0009395)4.41761337
60* epidermis development (GO:0008544)4.35534183
61positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)4.34007573
62peptidyl-proline hydroxylation (GO:0019511)4.29221498
63phosphatidylglycerol acyl-chain remodeling (GO:0036148)4.27840852
64regulation of complement activation (GO:0030449)4.21249474
65phosphatidylinositol acyl-chain remodeling (GO:0036149)4.05136656
66* epithelium development (GO:0060429)4.04868191
67defense response to fungus (GO:0050832)4.03085149
68positive regulation of granulocyte chemotaxis (GO:0071624)3.90310499
69regulation of protein activation cascade (GO:2000257)3.88341518
70sulfate transport (GO:0008272)3.84596177
71* epidermal cell differentiation (GO:0009913)3.82062303
72regulation of apoptotic cell clearance (GO:2000425)3.79867976
73atrioventricular valve morphogenesis (GO:0003181)3.78673711
74detection of biotic stimulus (GO:0009595)3.76851950
75positive regulation of metanephros development (GO:0072216)3.76802982
76low-density lipoprotein particle clearance (GO:0034383)3.75579483
77establishment of tissue polarity (GO:0007164)3.73489139
78establishment of planar polarity (GO:0001736)3.73489139
79ceramide biosynthetic process (GO:0046513)3.66393390
80O-glycan processing (GO:0016266)3.65465287
81regulation of lymphocyte chemotaxis (GO:1901623)3.64152061
82phosphatidylglycerol metabolic process (GO:0046471)3.61263144
83regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)3.54053029
84* epithelial cell differentiation (GO:0030855)3.53237595
85phosphatidylserine metabolic process (GO:0006658)3.52551663
86branching involved in salivary gland morphogenesis (GO:0060445)3.42753586
87positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.39600930
88regulation of osteoblast proliferation (GO:0033688)3.38068398
89wound healing, spreading of cells (GO:0044319)3.33453969
90regulation of T cell migration (GO:2000404)3.31079842
91eyelid development in camera-type eye (GO:0061029)3.30576470
92cellular response to arsenic-containing substance (GO:0071243)3.28762806
93regulation of cardioblast differentiation (GO:0051890)3.27345212
94planar cell polarity pathway involved in neural tube closure (GO:0090179)3.26867253
95cytoskeletal anchoring at plasma membrane (GO:0007016)3.24650090
96protein hydroxylation (GO:0018126)3.23107724
97regulation of water loss via skin (GO:0033561)3.21425258
98positive regulation of T cell migration (GO:2000406)3.19551380
99skin morphogenesis (GO:0043589)3.18917820
100positive regulation of macrophage differentiation (GO:0045651)3.14846656
101regulation of interleukin-17 production (GO:0032660)3.12346606
102surfactant homeostasis (GO:0043129)3.10670189
103response to phenylpropanoid (GO:0080184)3.09403674
104negative regulation of lymphocyte differentiation (GO:0045620)3.08432988
105negative regulation of cell fate specification (GO:0009996)3.06396558
106regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.05793198
107positive regulation of male gonad development (GO:2000020)3.04569532
108vitamin A metabolic process (GO:0006776)3.01662196
109antimicrobial humoral response (GO:0019730)3.00418941
110phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.98052029
111bundle of His cell to Purkinje myocyte communication (GO:0086069)2.96864739
112cell-substrate junction assembly (GO:0007044)2.95249086
113antibacterial humoral response (GO:0019731)2.95185264
114regulation of neuron projection regeneration (GO:0070570)2.93958559
115regulation of axon regeneration (GO:0048679)2.93958559
116negative regulation of osteoclast differentiation (GO:0045671)2.92859615
117defense response to Gram-negative bacterium (GO:0050829)2.89842745
118innate immune response in mucosa (GO:0002227)2.88344545
119positive regulation of histone acetylation (GO:0035066)2.88159268
120regulation of natural killer cell activation (GO:0032814)2.83858427
121ventricular cardiac muscle cell action potential (GO:0086005)2.82279369
122chaperone mediated protein folding requiring cofactor (GO:0051085)2.82006723
123trophoblast giant cell differentiation (GO:0060707)2.81044823
124positive regulation of epidermis development (GO:0045684)2.79567926
125keratinocyte development (GO:0003334)2.79559952
126negative regulation of keratinocyte proliferation (GO:0010839)2.75264470
127L-serine transport (GO:0015825)2.75095993
128protein maturation by protein folding (GO:0022417)2.72219064
129alditol phosphate metabolic process (GO:0052646)2.71835511
130male genitalia development (GO:0030539)2.70502741
131positive regulation of p38MAPK cascade (GO:1900745)2.69941067
132chemical homeostasis within a tissue (GO:0048875)2.69021762
133cellular modified amino acid biosynthetic process (GO:0042398)2.66605550
134positive regulation of peptidyl-lysine acetylation (GO:2000758)2.66371927
135positive regulation of protein acetylation (GO:1901985)2.66371927
136epithelial cell-cell adhesion (GO:0090136)2.66234360
137hair follicle morphogenesis (GO:0031069)2.66111639
138embryo implantation (GO:0007566)2.64978872
139desmosome organization (GO:0002934)2.64193752
140myotube differentiation (GO:0014902)2.64109164
141regulation of respiratory burst (GO:0060263)2.62533932
142cell adhesion mediated by integrin (GO:0033627)2.61570473
143cell differentiation involved in embryonic placenta development (GO:0060706)2.60020615
144establishment of skin barrier (GO:0061436)2.59762066
145phosphatidylcholine metabolic process (GO:0046470)2.57799485
146response to UV-B (GO:0010224)2.56615499
147regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)2.55992093
148regulation of granulocyte chemotaxis (GO:0071622)2.54340524
149negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.54053434
150regulation of humoral immune response (GO:0002920)2.53724111
151renal system development (GO:0072001)2.53387074
152phosphatidic acid biosynthetic process (GO:0006654)2.53080580
153phosphatidic acid metabolic process (GO:0046473)2.53080580
154hair cell differentiation (GO:0035315)2.50942288
155regulation of triglyceride biosynthetic process (GO:0010866)2.50657691
156positive regulation of lymphocyte migration (GO:2000403)2.50650793
157regulation of gonadotropin secretion (GO:0032276)2.49986414
158negative regulation of interleukin-6 production (GO:0032715)2.49101660
159regulation of male gonad development (GO:2000018)2.48498624
160regulation of RIG-I signaling pathway (GO:0039535)2.47552810
161regulation of metanephros development (GO:0072215)2.47191928
162bone morphogenesis (GO:0060349)2.47190502
163negative regulation of metanephros development (GO:0072217)2.46403889
164apoptotic cell clearance (GO:0043277)2.45929193
165calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.44673474
166serine transport (GO:0032329)2.41962381
167detection of bacterium (GO:0016045)2.41617779
168sex determination (GO:0007530)2.40284505
169regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.36109791
170oocyte development (GO:0048599)2.32884017
171sphingolipid biosynthetic process (GO:0030148)2.31452745
172transepithelial transport (GO:0070633)2.30474732
173regulation of heart rate by cardiac conduction (GO:0086091)2.30263157
174unsaturated fatty acid biosynthetic process (GO:0006636)2.29958139
175polarized epithelial cell differentiation (GO:0030859)2.26895130
176response to fungus (GO:0009620)2.26774534
177cellular response to gonadotropin stimulus (GO:0071371)2.26273344
178citrulline biosynthetic process (GO:0019240)14.5086666
179peptide cross-linking (GO:0018149)12.5040888

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.04074073
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.39780700
3ESR1_15608294_ChIP-ChIP_MCF-7_Human4.67116764
4ESR1_21235772_ChIP-Seq_MCF-7_Human3.40780836
5PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.35528205
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.24151186
7ESR2_21235772_ChIP-Seq_MCF-7_Human3.17491538
8TRIM28_21343339_ChIP-Seq_HEK293_Human3.05845992
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.93648099
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.78918602
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.76375354
12HIF1A_21447827_ChIP-Seq_MCF-7_Human2.60024911
13ZNF263_19887448_ChIP-Seq_K562_Human2.59032172
14IKZF1_21737484_ChIP-ChIP_HCT116_Human2.33168454
15CLOCK_20551151_ChIP-Seq_293T_Human2.26238757
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.22881910
17SOX2_20726797_ChIP-Seq_SW620_Human2.08460097
18KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.06309609
19CDX2_20551321_ChIP-Seq_CACO-2_Human2.06152332
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.02448345
21* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.96632104
22RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.96223703
23CDX2_19796622_ChIP-Seq_MESCs_Mouse1.84288423
24SOX2_27498859_Chip-Seq_STOMACH_Mouse1.83108165
25ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.82610586
26TP63_22573176_ChIP-Seq_HFKS_Human1.77348743
27FOXO3_23340844_ChIP-Seq_DLD1_Human1.76788116
28ZNF217_24962896_ChIP-Seq_MCF-7_Human1.74350324
29ESR1_20079471_ChIP-ChIP_T-47D_Human1.73085282
30SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.72125264
31KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.71634106
32SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.67171381
33SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.67171381
34* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.65705562
35* ERG_20517297_ChIP-Seq_VCAP_Human1.65666254
36ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.62279377
37CTCF_27219007_Chip-Seq_Bcells_Human1.61353777
38SCL_19346495_ChIP-Seq_HPC-7_Human1.61349425
39* GATA6_21074721_ChIP-Seq_CACO-2_Human1.60966097
40TCF4_18268006_ChIP-ChIP_LS174T_Human1.60397601
41TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.59195707
42RACK7_27058665_Chip-Seq_MCF-7_Human1.58407003
43VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.56752039
44TP63_23658742_ChIP-Seq_EP156T_Human1.53353578
45E2F1_20622854_ChIP-Seq_HELA_Human1.52309728
46ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.51460287
47RUNX1_27514584_Chip-Seq_MCF-7_Human1.42346801
48LXR_22292898_ChIP-Seq_THP-1_Human1.40147311
49ATF3_27146783_Chip-Seq_COLON_Human1.39913346
50CTCF_20526341_ChIP-Seq_ESCs_Human1.39590779
51ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.38777338
52TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.38420325
53BCOR_27268052_Chip-Seq_Bcells_Human1.37240198
54AHR_22903824_ChIP-Seq_MCF-7_Human1.35939686
55RXR_22158963_ChIP-Seq_LIVER_Mouse1.34504944
56ZFP281_18757296_ChIP-ChIP_E14_Mouse1.33393799
57ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.32838556
58GATA4_25053715_ChIP-Seq_YYC3_Human1.30863143
59SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.30592649
60ELK3_25401928_ChIP-Seq_HUVEC_Human1.29547619
61SA1_27219007_Chip-Seq_ERYTHROID_Human1.29123056
62KDM2B_26808549_Chip-Seq_K562_Human1.28836007
63TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.28681984
64KLF5_25053715_ChIP-Seq_YYC3_Human1.25739375
65LXR_22158963_ChIP-Seq_LIVER_Mouse1.25624771
66RXR_22108803_ChIP-Seq_LS180_Human1.25451210
67ERG_21242973_ChIP-ChIP_JURKAT_Human1.23649949
68GATA6_25053715_ChIP-Seq_YYC3_Human1.22557829
69KDM2B_26808549_Chip-Seq_SUP-B15_Human1.22149472
70* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.21824020
71PPARA_22158963_ChIP-Seq_LIVER_Mouse1.21716132
72BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.20553323
73FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.20393240
74GATA1_19941826_ChIP-Seq_K562_Human1.19532070
75NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.19027049
76STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.18235942
77FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.17849693
78P63_26484246_Chip-Seq_KERATINOCYTES_Human1.16750748
79EGR1_19032775_ChIP-ChIP_M12_Human1.14955170
80SOX9_24532713_ChIP-Seq_HFSC_Mouse1.14095353
81GATA2_21666600_ChIP-Seq_HMVEC_Human1.13845938
82P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.12925905
83MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.10999603
84P53_21459846_ChIP-Seq_SAOS-2_Human1.08873193
85GATA3_24758297_ChIP-Seq_MCF-7_Human1.07668128
86EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.05929987
87POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.05669447
88NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.05332561
89SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.01502402
90SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.01212000
91P300_27058665_Chip-Seq_ZR-75-30cells_Human1.01052948
92TP53_20018659_ChIP-ChIP_R1E_Mouse1.00273737
93STAT6_21828071_ChIP-Seq_BEAS2B_Human1.00256186
94VDR_22108803_ChIP-Seq_LS180_Human0.99779959
95* BCL6_27268052_Chip-Seq_Bcells_Human0.98603896
96BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.98517846
97* P300_27268052_Chip-Seq_Bcells_Human0.98043057
98NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97954396
99ZFP281_27345836_Chip-Seq_ESCs_Mouse0.97882511
100GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.97863905
101WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97686434
102P68_20966046_ChIP-Seq_HELA_Human0.96887980
103GATA2_19941826_ChIP-Seq_K562_Human0.96466158
104* RBPJ_21746931_ChIP-Seq_IB4_Human0.96432492
105JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95927423
106PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.95720365
107ARNT_22903824_ChIP-Seq_MCF-7_Human0.94428169
108YY1_22570637_ChIP-Seq_MALME-3M_Human0.92679893
109NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.92157345
110UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.90781151
111STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.90595055
112EZH2_18974828_ChIP-Seq_MESCs_Mouse0.90387379
113RNF2_18974828_ChIP-Seq_MESCs_Mouse0.90387379
114SMC4_20622854_ChIP-Seq_HELA_Human0.89760178
115DROSHA_22980978_ChIP-Seq_HELA_Human0.89603258
116SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89515633
117RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.87928491
118CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.87692173
119CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.87691996
120ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.86942340
121UBF1/2_26484160_Chip-Seq_HMECs_Human0.86788470
122FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.86274502
123CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.85873436
124HTT_18923047_ChIP-ChIP_STHdh_Human0.85701175
125TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85672211
126PHF8_20622854_ChIP-Seq_HELA_Human0.85370582
127SUZ12_27294783_Chip-Seq_ESCs_Mouse0.85289914
128CJUN_26792858_Chip-Seq_BT549_Human0.84854323
129JARID2_20075857_ChIP-Seq_MESCs_Mouse0.84821756
130JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84753937
131OCT4_18692474_ChIP-Seq_MEFs_Mouse0.83779385
132NANOG_20526341_ChIP-Seq_ESCs_Human0.83681345
133CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.83241807
134EGR1_19374776_ChIP-ChIP_THP-1_Human0.82607250
135AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.82293771
136PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.79688295
137AR_21909140_ChIP-Seq_LNCAP_Human0.79290292
138CEBPB_22108803_ChIP-Seq_LS180_Human0.79060934
139RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78702000
140CREB1_26743006_Chip-Seq_LNCaP_Human0.77967372
141FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.76920424
142TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.76783269
143TAF2_19829295_ChIP-Seq_ESCs_Human0.75802707
144BP1_19119308_ChIP-ChIP_Hs578T_Human0.75715546
145RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.74886724
146RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.73505116
147FOXH1_21741376_ChIP-Seq_ESCs_Human0.73458023

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle8.31198632
2MP0004885_abnormal_endolymph4.57216916
3MP0002254_reproductive_system_inflammat3.69901426
4MP0002796_impaired_skin_barrier3.69047945
5MP0005083_abnormal_biliary_tract3.22472098
6MP0003878_abnormal_ear_physiology3.19363135
7MP0005377_hearing/vestibular/ear_phenot3.19363135
8MP0010678_abnormal_skin_adnexa3.16177776
9MP0005275_abnormal_skin_tensile2.76144096
10MP0003705_abnormal_hypodermis_morpholog2.61735201
11MP0000537_abnormal_urethra_morphology2.57142493
12MP0004264_abnormal_extraembryonic_tissu2.55280101
13MP0003436_decreased_susceptibility_to2.22840725
14MP0003566_abnormal_cell_adhesion2.22610739
15MP0006054_spinal_hemorrhage2.18649136
16MP0003866_abnormal_defecation2.15712251
17MP0005501_abnormal_skin_physiology2.13446683
18MP0003941_abnormal_skin_development2.12995755
19MP0001849_ear_inflammation2.03454553
20MP0001666_abnormal_nutrient_absorption2.03211599
21MP0001188_hyperpigmentation1.92963818
22MP0008438_abnormal_cutaneous_collagen1.89110859
23MP0004272_abnormal_basement_membrane1.86440880
24MP0002909_abnormal_adrenal_gland1.80350559
25MP0008004_abnormal_stomach_pH1.79033331
26MP0001485_abnormal_pinna_reflex1.78998587
27MP0000383_abnormal_hair_follicle1.76930424
28MP0005409_darkened_coat_color1.73434152
29MP0002060_abnormal_skin_morphology1.71726624
30MP0002098_abnormal_vibrissa_morphology1.67767280
31MP0001216_abnormal_epidermal_layer1.67570844
32MP0004019_abnormal_vitamin_homeostasis1.65961997
33MP0001765_abnormal_ion_homeostasis1.65631716
34MP0004381_abnormal_hair_follicle1.65064334
35MP0003011_delayed_dark_adaptation1.63352013
36MP0003453_abnormal_keratinocyte_physiol1.59472063
37MP0004947_skin_inflammation1.56818055
38MP0003045_fibrosis1.56487524
39MP0005085_abnormal_gallbladder_physiolo1.55024689
40MP0001881_abnormal_mammary_gland1.51661120
41MP0004782_abnormal_surfactant_physiolog1.51612206
42MP0010771_integument_phenotype1.50987457
43MP0003303_peritoneal_inflammation1.48999779
44MP0009785_altered_susceptibility_to1.44016448
45MP0005166_decreased_susceptibility_to1.41943355
46MP0000566_synostosis1.38830097
47MP0004185_abnormal_adipocyte_glucose1.38481193
48MP0003075_altered_response_to1.36983667
49MP0000762_abnormal_tongue_morphology1.36832332
50MP0004742_abnormal_vestibular_system1.33855969
51MP0002138_abnormal_hepatobiliary_system1.32664052
52MP0004043_abnormal_pH_regulation1.32434715
53MP0009053_abnormal_anal_canal1.29821143
54MP0003315_abnormal_perineum_morphology1.26672607
55MP0010368_abnormal_lymphatic_system1.25917491
56MP0001727_abnormal_embryo_implantation1.20181736
57MP0000579_abnormal_nail_morphology1.17564017
58MP0000465_gastrointestinal_hemorrhage1.15977484
59MP0000627_abnormal_mammary_gland1.08683119
60MP0000367_abnormal_coat/_hair1.08402376
61MP0000467_abnormal_esophagus_morphology1.04620680
62MP0005310_abnormal_salivary_gland1.01650469
63MP0001191_abnormal_skin_condition0.98644859
64MP0009643_abnormal_urine_homeostasis0.97539799
65MP0002095_abnormal_skin_pigmentation0.94897473
66MP0001533_abnormal_skeleton_physiology0.94831629
67MP0005167_abnormal_blood-brain_barrier0.94751789
68MP0003329_amyloid_beta_deposits0.94300777
69MP0000377_abnormal_hair_follicle0.90478400
70MP0010352_gastrointestinal_tract_polyps0.88822277
71MP0004858_abnormal_nervous_system0.87554587
72MP0002234_abnormal_pharynx_morphology0.86548216
73MP0001958_emphysema0.86440625
74MP0000604_amyloidosis0.85652997
75MP0008995_early_reproductive_senescence0.85348549
76MP0005636_abnormal_mineral_homeostasis0.85061677
77MP0005666_abnormal_adipose_tissue0.84966476
78MP0002139_abnormal_hepatobiliary_system0.83977666
79MP0001784_abnormal_fluid_regulation0.82713409
80MP0009931_abnormal_skin_appearance0.81358124
81MP0001664_abnormal_digestion0.81039865
82MP0000249_abnormal_blood_vessel0.81021361
83MP0010030_abnormal_orbit_morphology0.79824218
84MP0003448_altered_tumor_morphology0.79280277
85MP0001243_abnormal_dermal_layer0.78147681
86MP0000462_abnormal_digestive_system0.77310278
87MP0005076_abnormal_cell_differentiation0.76763264
88MP0005187_abnormal_penis_morphology0.75463728
89MP0003115_abnormal_respiratory_system0.74566237
90MP0003300_gastrointestinal_ulcer0.73953142
91MP0005503_abnormal_tendon_morphology0.72038455
92MP0000477_abnormal_intestine_morphology0.70716293
93MP0005023_abnormal_wound_healing0.69503871
94MP0003191_abnormal_cellular_cholesterol0.69447987
95MP0002295_abnormal_pulmonary_circulatio0.68731853
96MP0005025_abnormal_response_to0.68467467
97MP0000678_abnormal_parathyroid_gland0.67227961
98MP0005164_abnormal_response_to0.66795419
99MP0001756_abnormal_urination0.66352577
100MP0002971_abnormal_brown_adipose0.64958077
101MP0000343_altered_response_to0.64760610
102MP0000427_abnormal_hair_cycle0.64603559
103MP0002168_other_aberrant_phenotype0.63995795
104MP0003936_abnormal_reproductive_system0.62332666
105MP0000647_abnormal_sebaceous_gland0.62327221
106MP0004883_abnormal_blood_vessel0.61946480
107MP0002998_abnormal_bone_remodeling0.61689989
108MP0006082_CNS_inflammation0.60119973
109MP0002419_abnormal_innate_immunity0.59444995
110MP0004484_altered_response_of0.57679334
111MP0002111_abnormal_tail_morphology0.56301546
112MP0000609_abnormal_liver_physiology0.55434965
113MP0001340_abnormal_eyelid_morphology0.54842332
114MP0003828_pulmonary_edema0.53878516
115MP0001851_eye_inflammation0.53307192
116MP0004808_abnormal_hematopoietic_stem0.52386253
117MP0005390_skeleton_phenotype0.52195566
118MP0002136_abnormal_kidney_physiology0.51344345
119MP0001614_abnormal_blood_vessel0.50689793
120MP0005508_abnormal_skeleton_morphology0.49820459
121MP0009840_abnormal_foam_cell0.49780662
122MP0008872_abnormal_physiological_respon0.48943427
123MP0000685_abnormal_immune_system0.48832123
124MP0003283_abnormal_digestive_organ0.47141649
125MP0009379_abnormal_foot_pigmentation0.46126155
126MP0002177_abnormal_outer_ear0.45171418
127MP0002282_abnormal_trachea_morphology0.44537344
128MP0002249_abnormal_larynx_morphology0.43292345
129MP0000470_abnormal_stomach_morphology0.43070457
130MP0000013_abnormal_adipose_tissue0.41577994
131MP0005375_adipose_tissue_phenotype0.36857813
132MP0008789_abnormal_olfactory_epithelium0.36484931
133MP0009333_abnormal_splenocyte_physiolog0.35016482
134MP0003755_abnormal_palate_morphology0.34453626
135MP0009384_cardiac_valve_regurgitation0.33041826
136MP0005394_taste/olfaction_phenotype0.32412912
137MP0005499_abnormal_olfactory_system0.32412912
138MP0004197_abnormal_fetal_growth/weight/0.30820454
139MP0005388_respiratory_system_phenotype0.30545182
140MP0002133_abnormal_respiratory_system0.30545182
141MP0003638_abnormal_response/metabolism_0.30001932
142MP0000003_abnormal_adipose_tissue0.25891263
143MP0001502_abnormal_circadian_rhythm0.21908258
144MP0002108_abnormal_muscle_morphology0.19518510
145MP0005193_abnormal_anterior_eye0.19315252
146MP0001661_extended_life_span0.19265179
147MP0000049_abnormal_middle_ear0.18333250
148MP0005075_abnormal_melanosome_morpholog0.16707138
149MP0003567_abnormal_fetal_cardiomyocyte0.16017149
150MP0009780_abnormal_chondrocyte_physiolo0.15634900
151MP0008260_abnormal_autophagy0.14654753
152MP0001177_atelectasis0.14373150
153MP0006138_congestive_heart_failure0.12743945
154MP0002233_abnormal_nose_morphology0.12463569
155MP0001542_abnormal_bone_strength0.10687443
156MP0005670_abnormal_white_adipose0.10359669
157MP0001186_pigmentation_phenotype0.10025147

Predicted human phenotypes

RankGene SetZ-score
1Erythroderma (HP:0001019)9.46461683
2Congenital nonbullous ichthyosiform erythroderma (HP:0007479)8.50048050
3Increased IgE level (HP:0003212)8.39896367
4Abnormality of cochlea (HP:0000375)8.19026641
5Onycholysis (HP:0001806)7.59319910
6Congenital sensorineural hearing impairment (HP:0008527)7.51772020
7Parakeratosis (HP:0001036)6.93200669
8Erythema (HP:0010783)6.51209580
9Morphological abnormality of the inner ear (HP:0011390)5.76441379
10Corneal erosion (HP:0200020)5.54436274
11Alopecia of scalp (HP:0002293)5.44679213
12Milia (HP:0001056)5.28902665
13Atrophic scars (HP:0001075)5.22568900
14Pili torti (HP:0003777)5.14538969
15Fragile nails (HP:0001808)4.91133030
16Conjunctival hamartoma (HP:0100780)4.88633550
17Gout (HP:0001997)4.71213376
18Hypotrichosis (HP:0001006)4.64193526
19Gangrene (HP:0100758)4.46309500
20Ectropion (HP:0000656)4.40541583
21Abnormality of secondary sexual hair (HP:0009888)4.39744763
22Abnormality of the axillary hair (HP:0100134)4.39744763
23Hyperparathyroidism (HP:0000843)4.19145965
24Hypohidrosis (HP:0000966)4.15080265
25Palmoplantar keratoderma (HP:0000982)4.05990863
26Plantar hyperkeratosis (HP:0007556)4.01788657
27Right ventricular cardiomyopathy (HP:0011663)3.94149075
28Pustule (HP:0200039)3.72275414
29Tracheal stenosis (HP:0002777)3.58340395
30Absent eyelashes (HP:0000561)3.54059660
31Lip pit (HP:0100267)3.51838041
32Complement deficiency (HP:0004431)3.49011071
33Curly hair (HP:0002212)3.48410054
34Sparse eyelashes (HP:0000653)3.41627565
35Abnormal hair laboratory examination (HP:0003328)3.39737354
36Abnormality of placental membranes (HP:0011409)3.31220260
37Amniotic constriction ring (HP:0009775)3.31220260
38Hamartoma of the eye (HP:0010568)3.30006633
39Absent hair (HP:0002298)3.25648248
40Furrowed tongue (HP:0000221)3.23648907
41Thyroid carcinoma (HP:0002890)3.10619684
42Split foot (HP:0001839)2.98008644
43Glomerulonephritis (HP:0000099)2.93273216
44Goiter (HP:0000853)2.89717311
45Glomerulosclerosis (HP:0000096)2.89257792
46Lack of skin elasticity (HP:0100679)2.83961291
47Nail dystrophy (HP:0008404)2.78978704
48Hemorrhage of the eye (HP:0011885)2.68083926
49Abnormal blistering of the skin (HP:0008066)2.64594056
50Autoamputation (HP:0001218)2.61183242
51Sparse scalp hair (HP:0002209)2.60946126
52Deep venous thrombosis (HP:0002625)2.60824178
53Abnormality of complement system (HP:0005339)2.59572065
54Abnormality of nail color (HP:0100643)2.55598137
55Abnormality of the salivary glands (HP:0010286)2.54378099
56Pruritus (HP:0000989)2.48402083
57Ankle contracture (HP:0006466)2.45911422
58Recurrent corneal erosions (HP:0000495)2.42782759
59Dehydration (HP:0001944)2.40305221
60Follicular hyperkeratosis (HP:0007502)2.39750725
61Brittle hair (HP:0002299)2.39576235
62Hyperuricemia (HP:0002149)2.38237359
63Increased purine levels (HP:0004368)2.38237359
64Laryngomalacia (HP:0001601)2.36848283
65Paralysis (HP:0003470)2.35324491
66Vertigo (HP:0002321)2.35054969
67Radial bowing (HP:0002986)2.29294546
68Hypoplasia of dental enamel (HP:0006297)2.28600998
69Urticaria (HP:0001025)2.27543138
70Bronchomalacia (HP:0002780)2.26656195
71Nephritis (HP:0000123)2.22763208
72Tubulointerstitial fibrosis (HP:0005576)2.21433038
73Bowed forearm bones (HP:0003956)2.20683425
74Bowing of the arm (HP:0006488)2.20683425
75Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.19333792
76Hypergammaglobulinemia (HP:0010702)2.18411676
77Micronodular cirrhosis (HP:0001413)2.16302730
78Focal segmental glomerulosclerosis (HP:0000097)2.16128009
79Cerebral aneurysm (HP:0004944)2.15601030
80Fragile skin (HP:0001030)2.14768656
81Multifactorial inheritance (HP:0001426)2.11122405
82Subacute progressive viral hepatitis (HP:0006572)2.10358622
83Humeroradial synostosis (HP:0003041)2.09787078
84Synostosis involving the elbow (HP:0003938)2.09787078
85Congenital ichthyosiform erythroderma (HP:0007431)2.08939075
86Abnormality of monocarboxylic acid metabolism (HP:0010996)2.05919339
87Premature rupture of membranes (HP:0001788)2.05672647
88Systemic lupus erythematosus (HP:0002725)2.05136334
89Interstitial pulmonary disease (HP:0006530)2.04991877
90Ankyloglossia (HP:0010296)2.03105464
91Palmoplantar hyperkeratosis (HP:0000972)2.01762413
92Ridged nail (HP:0001807)2.00524868
93Arterial tortuosity (HP:0005116)1.97664909
94Hydroureter (HP:0000072)1.96963521
95Vascular calcification (HP:0004934)1.95920974
96Cardiovascular calcification (HP:0011915)1.95473893
97Rectal prolapse (HP:0002035)1.95284596
98Axonal loss (HP:0003447)1.91206871
99Keratoconjunctivitis sicca (HP:0001097)1.89653804
100Shallow orbits (HP:0000586)1.86992092
101Intrahepatic cholestasis (HP:0001406)1.86890744
102Vascular tortuosity (HP:0004948)1.86687350
103Polycythemia (HP:0001901)1.83417157
104Melanocytic nevus (HP:0000995)1.82957467
105Aortic aneurysm (HP:0004942)1.82446767
106Renal salt wasting (HP:0000127)1.81705541
107Cervical subluxation (HP:0003308)1.81268273
108Palmar hyperkeratosis (HP:0010765)1.81241782
109Abnormality of purine metabolism (HP:0004352)1.81028814
110Tubulointerstitial nephritis (HP:0001970)1.79522951
111Woolly hair (HP:0002224)1.79226853
112Hyperhidrosis (HP:0000975)1.77608336
113Aortic dissection (HP:0002647)1.76425130
114Villous atrophy (HP:0011473)1.75225131
115Abnormality of small intestinal villus morphology (HP:0011472)1.75225131
116Advanced eruption of teeth (HP:0006288)1.73704069
117Esophageal varix (HP:0002040)1.72385150
118Blepharitis (HP:0000498)1.72079882
119Ulnar bowing (HP:0003031)1.71371700
120Natal tooth (HP:0000695)1.69549428
121Keratoconjunctivitis (HP:0001096)1.69300951
122Mildly elevated creatine phosphokinase (HP:0008180)1.69288185
123Sepsis (HP:0100806)1.69130635
124Gonadal dysgenesis (HP:0000133)1.68765949
125Corneal dystrophy (HP:0001131)1.68217959
126Thick nail (HP:0001805)1.68049241
127Germ cell neoplasia (HP:0100728)1.67911503
128Type 1 muscle fiber predominance (HP:0003803)1.67349774
129Abnormality of macular pigmentation (HP:0008002)1.67058649
130Increased cerebral lipofuscin (HP:0011813)1.64080619
131Abnormality of oral frenula (HP:0000190)1.63852743
132Cheilitis (HP:0100825)1.62446599
133Tarsal synostosis (HP:0008368)1.61968841
134Verrucae (HP:0200043)1.60840428
135Papilloma (HP:0012740)1.60840428
136Fibular aplasia (HP:0002990)1.58495870
137Skin ulcer (HP:0200042)1.58059059
138Acanthosis nigricans (HP:0000956)1.54845820
139Cerebral inclusion bodies (HP:0100314)1.53751613
140Protrusio acetabuli (HP:0003179)1.53686497
141Hypoplastic toenails (HP:0001800)1.53325500
142Preauricular skin tag (HP:0000384)1.52426878
143Fine hair (HP:0002213)1.52107744
144Abnormality of the nasal mucosa (HP:0000433)1.52016059
145Central scotoma (HP:0000603)1.51326145
146Anonychia (HP:0001798)1.50089699
147Synostosis involving bones of the feet (HP:0009140)1.49301326
148Synostosis involving bones of the lower limbs (HP:0009138)1.49301326
149Elbow flexion contracture (HP:0002987)1.49226774
150Tubular atrophy (HP:0000092)1.49035914
151Xanthomatosis (HP:0000991)1.48493326
152Abnormalities of placenta or umbilical cord (HP:0001194)1.48483566
153Aplasia/hypoplasia of the uterus (HP:0008684)1.47376216
154Oral leukoplakia (HP:0002745)1.46238004
155Carious teeth (HP:0000670)1.46183592
156Hamartoma (HP:0010566)1.44186527
157Skin pits (HP:0100276)1.42732018
158Abnormality of the fingernails (HP:0001231)1.42025005
159Dry skin (HP:0000958)1.40145461
160Recurrent bacterial skin infections (HP:0005406)1.31846125
161Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.27259387
162Slow-growing hair (HP:0002217)1.27225664
163Abnormality of hair growth rate (HP:0011363)1.27225664
164Everted lower lip vermilion (HP:0000232)1.27074794
165Skin tags (HP:0010609)1.25642684
166Ventricular tachycardia (HP:0004756)1.23869176
167Squamous cell carcinoma (HP:0002860)1.16480215
168Xerostomia (HP:0000217)1.11461775
169Hypoplastic labia majora (HP:0000059)1.09247563
170Gonadotropin excess (HP:0000837)1.08387641
171Eczematoid dermatitis (HP:0000976)1.06648725
172Popliteal pterygium (HP:0009756)1.06129959
173Abnormality of the neuromuscular junction (HP:0003398)1.05809001
174Fatigable weakness (HP:0003473)1.05809001
175Acanthocytosis (HP:0001927)1.04325206
176Trismus (HP:0000211)1.00301802

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K65.55474685
2TGFBR14.30697289
3PRPF4B3.36339820
4EPHB23.10350682
5NLK2.68529110
6MST1R2.58579878
7STK242.52316208
8MAP3K92.24119362
9MST42.17738120
10FRK2.16249470
11FER2.09735467
12SGK2232.07704232
13SGK4942.07704232
14EPHB12.00179639
15EPHA211.5860557
16TAOK21.99412781
17LMTK21.98837762
18TRIB31.95382531
19PTK61.82290772
20PKN21.74547073
21PTK21.66436733
22MAPK151.54397800
23RIPK11.54250600
24GRK61.41688766
25PRKD21.41186772
26BMX1.36862849
27TSSK61.36146265
28MAP3K21.35883412
29BMPR1B1.34023445
30PAK41.26520242
31MUSK1.20297797
32TGFBR21.18907229
33SIK11.18869971
34WNK11.16289160
35MYLK1.14294188
36IKBKB1.13726663
37MET1.13539790
38NME11.12193750
39ERN11.08402043
40PRKD31.05087226
41ZAP701.04324564
42DDR21.03461427
43MAPK71.01943663
44TBK11.01637424
45IRAK10.96966948
46KSR20.96449224
47LRRK20.93472807
48MAP2K10.90346590
49PDGFRB0.87455607
50MAP3K10.86975356
51MAP2K20.86415354
52ERBB20.83990781
53MAPKAPK50.81436420
54EPHA30.80195709
55FGFR40.79778339
56TRPM70.79775735
57EIF2AK30.77864111
58RPS6KB20.77711683
59PDK20.77315651
60EEF2K0.75787295
61BLK0.74858849
62TESK10.73453790
63PRKG20.72451713
64STK30.71426678
65CDK190.70417474
66ERBB30.69977440
67BRSK10.69788215
68DYRK20.69135502
69KSR10.67975993
70STK390.67060297
71PAK30.66849445
72RPS6KA50.62600364
73CDK70.62581026
74RPS6KC10.61988130
75RPS6KL10.61988130
76FGFR10.61078843
77TTN0.60370348
78MAP3K50.60205575
79STK100.60149959
80SRC0.60142536
81MAP3K100.59798839
82ACVR1B0.59621297
83MATK0.59585537
84BRD40.59227737
85PDGFRA0.57911303
86ALK0.56788302
87MAP3K30.56178276
88TYK20.56105316
89STK38L0.55043896
90CAMK1G0.53797147
91MAPKAPK20.53506166
92PRKAA20.52180058
93PTK2B0.51568969
94TIE10.51453052
95MARK20.50878102
96SGK10.50034485
97LATS10.49894197
98CAMK1D0.49689923
99MAP3K140.49609219
100MAPKAPK30.49545060
101TYRO30.49138536
102RPS6KA60.49118252
103PAK20.47613447
104JAK30.47092454
105PIM20.46389764
106MAP3K120.46347203
107PAK10.45212215
108FGFR30.45109369
109EGFR0.44231296
110MAP2K60.42964246
111PBK0.42724215
112NTRK10.42556604
113MAP2K40.42423478
114BMPR20.41501783
115ADRBK10.41484212
116IKBKE0.41168628
117CDC42BPA0.40580229
118MAP3K130.40331055
119MAP3K110.38992808
120ERBB40.38385050
121DAPK20.37768389
122CSK0.36798293
123PRKCE0.36466582
124TAOK10.36067040
125ABL20.36021117
126GSK3A0.35874189
127DMPK0.34577129
128BCKDK0.34215052
129PRKCI0.34180192
130RET0.34093364
131SGK20.33385415
132JAK10.33345790
133PRKD10.32812388
134MAP3K80.31552161
135LATS20.29158947
136ROCK20.28870863
137CSNK1A1L0.28859459
138FYN0.28500406
139CDK90.27770554
140ICK0.27422360
141STK380.27152858
142MELK0.26541573
143MTOR0.24446557
144RPS6KA10.23569357
145JAK20.22099951
146CSNK1G30.21063389
147RPS6KA20.20733441
148MAP3K70.20439018
149ABL10.20247151
150IGF1R0.20065597
151FGFR20.20007843
152PDPK10.19973225
153LIMK10.19964265
154FGR0.18563269
155CDK60.18288861

Predicted pathways (KEGG)

RankGene SetZ-score
1Linoleic acid metabolism_Homo sapiens_hsa005913.42899852
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.38784668
3Staphylococcus aureus infection_Homo sapiens_hsa051503.34688289
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.33267975
5Mineral absorption_Homo sapiens_hsa049783.06815757
6Ovarian steroidogenesis_Homo sapiens_hsa049132.94207243
7Fat digestion and absorption_Homo sapiens_hsa049752.88343617
8ECM-receptor interaction_Homo sapiens_hsa045121.99275876
9Complement and coagulation cascades_Homo sapiens_hsa046101.94912229
10Long-term depression_Homo sapiens_hsa047301.90808635
11Thyroid hormone synthesis_Homo sapiens_hsa049181.81163856
12Ether lipid metabolism_Homo sapiens_hsa005651.74415917
13Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.71530081
14Amoebiasis_Homo sapiens_hsa051461.53282480
15Toxoplasmosis_Homo sapiens_hsa051451.50847169
16Salivary secretion_Homo sapiens_hsa049701.50119418
17Tight junction_Homo sapiens_hsa045301.47252475
18Serotonergic synapse_Homo sapiens_hsa047261.46623894
19Arachidonic acid metabolism_Homo sapiens_hsa005901.43797932
20Phototransduction_Homo sapiens_hsa047441.40333345
21Leukocyte transendothelial migration_Homo sapiens_hsa046701.38390829
22Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.36979662
23Sphingolipid metabolism_Homo sapiens_hsa006001.36834198
24Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.33082225
25Pertussis_Homo sapiens_hsa051331.32215084
26Choline metabolism in cancer_Homo sapiens_hsa052311.30238100
27Small cell lung cancer_Homo sapiens_hsa052221.29766773
28Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.26261802
29Leishmaniasis_Homo sapiens_hsa051401.25370245
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.20807542
31Histidine metabolism_Homo sapiens_hsa003401.19435424
32Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.17578488
33Legionellosis_Homo sapiens_hsa051341.16440276
34Proteoglycans in cancer_Homo sapiens_hsa052051.14363929
35Focal adhesion_Homo sapiens_hsa045101.13904025
36Adherens junction_Homo sapiens_hsa045201.13415744
37Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.13132979
38Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.08503398
39Renal cell carcinoma_Homo sapiens_hsa052111.07425058
40HIF-1 signaling pathway_Homo sapiens_hsa040661.07162940
41TNF signaling pathway_Homo sapiens_hsa046681.05928636
42Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.05811320
43Pancreatic secretion_Homo sapiens_hsa049721.05604637
44Nitrogen metabolism_Homo sapiens_hsa009101.02620619
45Salmonella infection_Homo sapiens_hsa051320.99417679
46Fatty acid biosynthesis_Homo sapiens_hsa000610.97771885
47Arginine biosynthesis_Homo sapiens_hsa002200.97583954
48Vibrio cholerae infection_Homo sapiens_hsa051100.97003173
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.96743478
50Circadian rhythm_Homo sapiens_hsa047100.96400271
51Phenylalanine metabolism_Homo sapiens_hsa003600.92666354
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91795493
53Hepatitis C_Homo sapiens_hsa051600.88585326
54Estrogen signaling pathway_Homo sapiens_hsa049150.86270731
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84774090
56Bile secretion_Homo sapiens_hsa049760.84258582
57VEGF signaling pathway_Homo sapiens_hsa043700.82372858
58Bladder cancer_Homo sapiens_hsa052190.81490312
59Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.77251670
60Gastric acid secretion_Homo sapiens_hsa049710.74107181
61TGF-beta signaling pathway_Homo sapiens_hsa043500.74011544
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.72037819
63Shigellosis_Homo sapiens_hsa051310.69973599
64Fatty acid elongation_Homo sapiens_hsa000620.69653699
65PPAR signaling pathway_Homo sapiens_hsa033200.67298768
66Oxytocin signaling pathway_Homo sapiens_hsa049210.66605798
67Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65339094
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64244803
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.64056075
70Malaria_Homo sapiens_hsa051440.63333706
71Antigen processing and presentation_Homo sapiens_hsa046120.62833867
72Central carbon metabolism in cancer_Homo sapiens_hsa052300.62320905
73Insulin resistance_Homo sapiens_hsa049310.62211190
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61746379
75Glutathione metabolism_Homo sapiens_hsa004800.61450708
76GnRH signaling pathway_Homo sapiens_hsa049120.61437226
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61294299
78Glutamatergic synapse_Homo sapiens_hsa047240.60300532
79Influenza A_Homo sapiens_hsa051640.60004745
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59866126
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.59720021
82Osteoclast differentiation_Homo sapiens_hsa043800.59002903
83Hippo signaling pathway_Homo sapiens_hsa043900.58818289
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.58291549
85Pyruvate metabolism_Homo sapiens_hsa006200.57498518
86Dorso-ventral axis formation_Homo sapiens_hsa043200.56357871
87Caffeine metabolism_Homo sapiens_hsa002320.55951970
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.55882296
89Hedgehog signaling pathway_Homo sapiens_hsa043400.55054297
90Pentose phosphate pathway_Homo sapiens_hsa000300.54606760
91Acute myeloid leukemia_Homo sapiens_hsa052210.53884371
92Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53560868
93Fructose and mannose metabolism_Homo sapiens_hsa000510.50414940
94Fatty acid metabolism_Homo sapiens_hsa012120.49768548
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49006422
96Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.47396409
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.47274573
98Thyroid cancer_Homo sapiens_hsa052160.47162050
992-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.46867195
100beta-Alanine metabolism_Homo sapiens_hsa004100.46750715
101Primary bile acid biosynthesis_Homo sapiens_hsa001200.45674746
102Dilated cardiomyopathy_Homo sapiens_hsa054140.45514393
103Hematopoietic cell lineage_Homo sapiens_hsa046400.45237516
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43909209
105Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43727870
106Starch and sucrose metabolism_Homo sapiens_hsa005000.43624864
107Renin secretion_Homo sapiens_hsa049240.43142170
108Melanogenesis_Homo sapiens_hsa049160.42952340
109Platelet activation_Homo sapiens_hsa046110.42840270
110Insulin signaling pathway_Homo sapiens_hsa049100.42490592
111Axon guidance_Homo sapiens_hsa043600.42127652
112Galactose metabolism_Homo sapiens_hsa000520.42055053
113Pathways in cancer_Homo sapiens_hsa052000.41540749
114Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41191019
115Rap1 signaling pathway_Homo sapiens_hsa040150.41140814
116Chemical carcinogenesis_Homo sapiens_hsa052040.40346763
117MAPK signaling pathway_Homo sapiens_hsa040100.39774630
118Arginine and proline metabolism_Homo sapiens_hsa003300.39699785
119Glucagon signaling pathway_Homo sapiens_hsa049220.38150379
120Glycerolipid metabolism_Homo sapiens_hsa005610.37921928
121PI3K-Akt signaling pathway_Homo sapiens_hsa041510.37254362
122Lysosome_Homo sapiens_hsa041420.36267103
123Tuberculosis_Homo sapiens_hsa051520.35809238
124Ras signaling pathway_Homo sapiens_hsa040140.34806733
125Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.34486729
126Prion diseases_Homo sapiens_hsa050200.34417729
127Phagosome_Homo sapiens_hsa041450.34189148
128Tyrosine metabolism_Homo sapiens_hsa003500.33803653
129Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33013504
130Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31669447
131Renin-angiotensin system_Homo sapiens_hsa046140.30332425
132Retinol metabolism_Homo sapiens_hsa008300.29621650
133Aldosterone synthesis and secretion_Homo sapiens_hsa049250.28791041
134Long-term potentiation_Homo sapiens_hsa047200.25708480
135p53 signaling pathway_Homo sapiens_hsa041150.17366376
136Cyanoamino acid metabolism_Homo sapiens_hsa004600.14767543
137Endocytosis_Homo sapiens_hsa041440.13950201
138mTOR signaling pathway_Homo sapiens_hsa041500.12315625
139NOD-like receptor signaling pathway_Homo sapiens_hsa046210.11689454
140Protein digestion and absorption_Homo sapiens_hsa049740.11469332
141Amphetamine addiction_Homo sapiens_hsa050310.10992198
142Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.10865241
143Glioma_Homo sapiens_hsa052140.10164457
144Sulfur metabolism_Homo sapiens_hsa009200.09118935
145Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.06647135
146Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.06616061
147Basal cell carcinoma_Homo sapiens_hsa052170.06158611
148Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.05776878
149Steroid biosynthesis_Homo sapiens_hsa001000.05569363
150Phosphatidylinositol signaling system_Homo sapiens_hsa040700.04825105
151cGMP-PKG signaling pathway_Homo sapiens_hsa040220.04108407
152Pancreatic cancer_Homo sapiens_hsa052120.03551462

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