SPRED1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)4.62261893
2locomotory exploration behavior (GO:0035641)4.57675376
3chondrocyte proliferation (GO:0035988)4.32950826
4retina vasculature morphogenesis in camera-type eye (GO:0061299)4.06623425
5regulation of short-term neuronal synaptic plasticity (GO:0048172)4.01556495
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.89568994
7L-amino acid import (GO:0043092)3.64014113
8paraxial mesoderm development (GO:0048339)3.62659709
9barbed-end actin filament capping (GO:0051016)3.58118381
10dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.54669521
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.51197742
12vocalization behavior (GO:0071625)3.47411063
13regulation of synapse structural plasticity (GO:0051823)3.45336824
14synaptic vesicle exocytosis (GO:0016079)3.45132985
15regulation of synaptic vesicle exocytosis (GO:2000300)3.39892947
16cell migration involved in sprouting angiogenesis (GO:0002042)3.39269763
17glutamate secretion (GO:0014047)3.38862042
18regulation of long-term neuronal synaptic plasticity (GO:0048169)3.33634287
19cellular potassium ion homeostasis (GO:0030007)3.33116768
20regulation of glutamate receptor signaling pathway (GO:1900449)3.32509833
21axon extension involved in axon guidance (GO:0048846)3.32460411
22neuron projection extension involved in neuron projection guidance (GO:1902284)3.32460411
23layer formation in cerebral cortex (GO:0021819)3.32112299
24exploration behavior (GO:0035640)3.26522725
25apoptotic cell clearance (GO:0043277)3.23950929
26synaptic vesicle docking involved in exocytosis (GO:0016081)3.22608642
27regulation of neuronal synaptic plasticity (GO:0048168)3.22152609
28presynaptic membrane assembly (GO:0097105)3.21573126
29ionotropic glutamate receptor signaling pathway (GO:0035235)3.20466682
30sodium ion export (GO:0071436)3.15497971
31amino acid import (GO:0043090)3.15296603
32endodermal cell differentiation (GO:0035987)3.10487120
33dermatan sulfate biosynthetic process (GO:0030208)3.10366891
34dendritic spine morphogenesis (GO:0060997)3.09289981
35positive regulation of macrophage cytokine production (GO:0060907)3.09017119
36positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.08811842
37negative regulation of chondrocyte differentiation (GO:0032331)3.05475481
38substrate-dependent cell migration (GO:0006929)3.02313509
39regulation of dendritic spine morphogenesis (GO:0061001)3.01174505
40neuromuscular process controlling balance (GO:0050885)3.01137607
41notochord development (GO:0030903)2.93750990
42membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.92215491
43neuronal action potential propagation (GO:0019227)2.89998172
44dendrite morphogenesis (GO:0048813)2.89760167
45planar cell polarity pathway involved in neural tube closure (GO:0090179)2.88976335
46nerve growth factor signaling pathway (GO:0038180)2.85847266
47glutamate receptor signaling pathway (GO:0007215)2.83278231
48establishment of nucleus localization (GO:0040023)2.83273509
49protein localization to endosome (GO:0036010)2.82247046
50endothelial cell chemotaxis (GO:0035767)2.81436463
51regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.80022822
52regulation of axon extension involved in axon guidance (GO:0048841)2.79271171
53regulation of synaptic vesicle transport (GO:1902803)2.78388460
54mesenchymal-epithelial cell signaling (GO:0060638)2.77804222
55membrane assembly (GO:0071709)2.77373933
56G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.77225387
57positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.76448585
58regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.76021146
59neurotransmitter secretion (GO:0007269)2.74763466
60collagen fibril organization (GO:0030199)2.74365862
61gamma-aminobutyric acid transport (GO:0015812)2.73866195
62presynaptic membrane organization (GO:0097090)2.73370047
63axon extension (GO:0048675)2.72313649
64dermatan sulfate metabolic process (GO:0030205)2.71890735
65skin morphogenesis (GO:0043589)2.71856796
66long-term synaptic potentiation (GO:0060291)2.71676755
67collagen metabolic process (GO:0032963)2.71270452
68vesicle transport along microtubule (GO:0047496)2.70941938
69collagen catabolic process (GO:0030574)2.70729575
70craniofacial suture morphogenesis (GO:0097094)2.67193235
71response to auditory stimulus (GO:0010996)2.65850214
72regulation of synaptic plasticity (GO:0048167)2.63687746
73hemidesmosome assembly (GO:0031581)2.63418027
74neuron cell-cell adhesion (GO:0007158)2.63138859
75regulation of clathrin-mediated endocytosis (GO:2000369)2.62091309
76protein localization to synapse (GO:0035418)2.61658390
77regulation of excitatory postsynaptic membrane potential (GO:0060079)2.61325245
78semaphorin-plexin signaling pathway (GO:0071526)2.61134228
79regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.60961688
80positive regulation of axon extension (GO:0045773)2.60571517
81prepulse inhibition (GO:0060134)2.60402903
82glial cell migration (GO:0008347)2.60400863
83activation of protein kinase A activity (GO:0034199)2.60399165
84regulation of dendritic spine development (GO:0060998)2.57554450
85regulation of axon guidance (GO:1902667)2.57282438
86modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.56958477
87modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.56958477
88positive regulation by organism of defense response of other organism involved in symbiotic interact2.56958477
89modulation by symbiont of host immune response (GO:0052553)2.56958477
90positive regulation by symbiont of host defense response (GO:0052509)2.56958477
91modulation by symbiont of host defense response (GO:0052031)2.56958477
92multicellular organismal macromolecule metabolic process (GO:0044259)2.56925735
93hippo signaling (GO:0035329)2.55802697
94cytoskeletal anchoring at plasma membrane (GO:0007016)2.54372400
95wound healing, spreading of epidermal cells (GO:0035313)2.53417884
96myelination in peripheral nervous system (GO:0022011)2.52770672
97peripheral nervous system axon ensheathment (GO:0032292)2.52770672
98clathrin coat assembly (GO:0048268)2.50821222
99negative regulation of axon extension involved in axon guidance (GO:0048843)2.49519666
100multicellular organismal catabolic process (GO:0044243)2.48756780
101artery development (GO:0060840)2.48530031
102substrate adhesion-dependent cell spreading (GO:0034446)2.47847933
103long-term memory (GO:0007616)2.47249613
104regulation of ARF protein signal transduction (GO:0032012)2.46936882
105synaptic transmission, glutamatergic (GO:0035249)2.45998505
106regulation of synaptic transmission, glutamatergic (GO:0051966)2.45799458
107proline transport (GO:0015824)2.45361153
108transmission of nerve impulse (GO:0019226)2.44782398
109negative regulation of amino acid transport (GO:0051956)2.44414572
110regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.44326818
111regulation of voltage-gated calcium channel activity (GO:1901385)2.44094420
112regulation of chemokine-mediated signaling pathway (GO:0070099)2.42225129
113postsynaptic membrane organization (GO:0001941)2.42034745
114neurotransmitter-gated ion channel clustering (GO:0072578)2.41909850
115adhesion of symbiont to host cell (GO:0044650)2.41784545
116virion attachment to host cell (GO:0019062)2.41784545
117lymphangiogenesis (GO:0001946)2.41393916
118neuron-neuron synaptic transmission (GO:0007270)2.40907502
119potassium ion import (GO:0010107)2.40606722
120anterior/posterior axis specification, embryo (GO:0008595)2.40154683
121glomerular visceral epithelial cell development (GO:0072015)2.39931862
122regulation of postsynaptic membrane potential (GO:0060078)2.39827930
123multicellular organismal metabolic process (GO:0044236)2.39586687
124astrocyte development (GO:0014002)2.39556015
125endothelial cell morphogenesis (GO:0001886)2.38843848
126gamma-aminobutyric acid signaling pathway (GO:0007214)2.38353102
127Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.38303900
128positive regulation of SMAD protein import into nucleus (GO:0060391)2.37796875
129cell surface receptor signaling pathway involved in heart development (GO:0061311)2.37713304
130vascular endothelial growth factor signaling pathway (GO:0038084)2.37690913
131neuron projection extension (GO:1990138)2.37670979
132Notch signaling involved in heart development (GO:0061314)2.37092393
133surfactant homeostasis (GO:0043129)2.36901671
134epithelial cell-cell adhesion (GO:0090136)2.35883004
135mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.35212038
136neuronal ion channel clustering (GO:0045161)2.35121659
137mesodermal cell differentiation (GO:0048333)2.34690511
138stress fiber assembly (GO:0043149)2.34205371
139axonal fasciculation (GO:0007413)2.34163692
140positive regulation of fibroblast migration (GO:0010763)2.33240807
141regulation of establishment of planar polarity (GO:0090175)2.32621283
142chemical homeostasis within a tissue (GO:0048875)2.32044063
143dendritic spine organization (GO:0097061)2.31978564
144lateral sprouting from an epithelium (GO:0060601)2.30630266
145convergent extension (GO:0060026)2.30143143
146negative regulation of protein localization to cell surface (GO:2000009)2.29990179
147cell adhesion mediated by integrin (GO:0033627)2.28768587
148G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.28732408
149neuron recognition (GO:0008038)2.27981853
150regulation of macrophage cytokine production (GO:0010935)2.27066868
151regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.26942144
152glycosphingolipid catabolic process (GO:0046479)2.26017988
153extracellular matrix disassembly (GO:0022617)2.25996379
154cerebral cortex cell migration (GO:0021795)2.25778841
155lens morphogenesis in camera-type eye (GO:0002089)2.25561980
156regulation of neurotransmitter secretion (GO:0046928)2.24716726
157auditory behavior (GO:0031223)2.24424765
158cerebellar granule cell differentiation (GO:0021707)2.24264014
159positive regulation of catenin import into nucleus (GO:0035413)2.23833725
160heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.23397634
161chondrocyte development (GO:0002063)2.22873507
162regulation of mononuclear cell migration (GO:0071675)2.22861530
163adenosine receptor signaling pathway (GO:0001973)2.21546364
164camera-type eye morphogenesis (GO:0048593)2.21439503
165neuron remodeling (GO:0016322)2.21058893
166negative regulation of axon guidance (GO:1902668)2.20946443
167ganglion development (GO:0061548)2.20650206
168regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.20580996
169regulation of cell fate specification (GO:0042659)2.20322563
170innervation (GO:0060384)2.20176587
171regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.18895115
172positive regulation of membrane potential (GO:0045838)2.18756022
173negative regulation of synaptic transmission, GABAergic (GO:0032229)2.18666583
174positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.18593893
175morphogenesis of an epithelial sheet (GO:0002011)2.18484606
176blood vessel endothelial cell migration (GO:0043534)2.18049041
177positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.17850484
178mating behavior (GO:0007617)2.17553507
179cellular response to cholesterol (GO:0071397)2.17149324
180negative regulation of neurotransmitter transport (GO:0051589)2.14554061
181neuromuscular process (GO:0050905)2.14520182
182positive regulation of synaptic transmission (GO:0050806)2.14489211
183regulation of neurotransmitter transport (GO:0051588)2.14040521
184cortical actin cytoskeleton organization (GO:0030866)2.13899476
185cerebellar Purkinje cell differentiation (GO:0021702)2.13637781
186regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.10731096
187cerebral cortex radially oriented cell migration (GO:0021799)2.10661759
188negative regulation of neurotransmitter secretion (GO:0046929)2.09898134
189G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.08141010
190neurotransmitter transport (GO:0006836)2.07811543

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.02052320
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.49140874
3GBX2_23144817_ChIP-Seq_PC3_Human2.44740009
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.40618571
5SMAD_19615063_ChIP-ChIP_OVARY_Human2.34203186
6NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.34018506
7AR_21572438_ChIP-Seq_LNCaP_Human2.33761370
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.32061360
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.24224089
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.24224089
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.21704176
12PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.11117088
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.09538595
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.09304569
15RBPJ_22232070_ChIP-Seq_NCS_Mouse2.06207781
16TP63_17297297_ChIP-ChIP_HaCaT_Human2.04884155
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.04793175
18TRIM28_21343339_ChIP-Seq_HEK293_Human2.02896686
19DROSHA_22980978_ChIP-Seq_HELA_Human1.95012524
20RARB_27405468_Chip-Seq_BRAIN_Mouse1.94794842
21GATA1_22025678_ChIP-Seq_K562_Human1.93408212
22JARID2_20075857_ChIP-Seq_MESCs_Mouse1.90995138
23CLOCK_20551151_ChIP-Seq_293T_Human1.88407621
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.85173552
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.84804306
26RNF2_27304074_Chip-Seq_ESCs_Mouse1.84172789
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.83765800
28TP53_16413492_ChIP-PET_HCT116_Human1.82535685
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.81287142
30TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.80752381
31ZNF217_24962896_ChIP-Seq_MCF-7_Human1.75537217
32WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.74628694
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.72256485
34EZH2_27304074_Chip-Seq_ESCs_Mouse1.69282997
35BRD4_25478319_ChIP-Seq_HGPS_Human1.64366037
36SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.63290491
37CDX2_19796622_ChIP-Seq_MESCs_Mouse1.62908196
38* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.62550953
39* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.58668115
40* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.55952965
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.51553192
42SUZ12_27294783_Chip-Seq_ESCs_Mouse1.48718275
43TP53_18474530_ChIP-ChIP_U2OS_Human1.46892446
44* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46347783
45VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.46098470
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44744695
47IKZF1_21737484_ChIP-ChIP_HCT116_Human1.43775823
48EZH2_27294783_Chip-Seq_ESCs_Mouse1.39542708
49SMAD4_21799915_ChIP-Seq_A2780_Human1.38135588
50WT1_25993318_ChIP-Seq_PODOCYTE_Human1.37454220
51* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.36650042
52* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.36650042
53* SMAD3_21741376_ChIP-Seq_EPCs_Human1.36571028
54* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36532178
55OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36325357
56* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35914790
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.35202741
58ISL1_27105846_Chip-Seq_CPCs_Mouse1.34622779
59SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.33490675
60EGR1_19374776_ChIP-ChIP_THP-1_Human1.33265238
61STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.29901548
62* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.28645692
63AHR_22903824_ChIP-Seq_MCF-7_Human1.28405297
64TCF3_18692474_ChIP-Seq_MEFs_Mouse1.27869135
65* RXR_22108803_ChIP-Seq_LS180_Human1.27395940
66WT1_19549856_ChIP-ChIP_CCG9911_Human1.27329389
67ARNT_22903824_ChIP-Seq_MCF-7_Human1.25953639
68TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25878565
69P300_19829295_ChIP-Seq_ESCs_Human1.24424992
70NFIB_24661679_ChIP-Seq_LUNG_Mouse1.24370920
71* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24145653
72MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.23888873
73* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.23446351
74REST_21632747_ChIP-Seq_MESCs_Mouse1.22039243
75PPAR_26484153_Chip-Seq_NCI-H1993_Human1.20970646
76PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.20184799
77CTBP2_25329375_ChIP-Seq_LNCAP_Human1.19764559
78EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19399072
79* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.19364622
80KDM2B_26808549_Chip-Seq_K562_Human1.19154052
81* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.18556742
82* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.17516042
83EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.17078201
84Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.16903370
85* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.16421077
86* SOX2_21211035_ChIP-Seq_LN229_Gbm1.15889934
87BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.13966871
88* RING1B_27294783_Chip-Seq_NPCs_Mouse1.13398700
89EP300_21415370_ChIP-Seq_HL-1_Mouse1.12353716
90AR_21909140_ChIP-Seq_LNCAP_Human1.12282002
91LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11973555
92TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.11875325
93TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.11829311
94AR_25329375_ChIP-Seq_VCAP_Human1.10490926
95RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.10480286
96* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.10277112
97KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10199067
98ZFP281_27345836_Chip-Seq_ESCs_Mouse1.10009817
99* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.09961012
100* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.09747630
101HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.09586597
102GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.09038430
103RING1B_27294783_Chip-Seq_ESCs_Mouse1.08882040
104* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.08635363
105VDR_24787735_ChIP-Seq_THP-1_Human1.08189194
106KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.07496476
107KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.07496476
108KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.07496476
109* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06899818
110TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06449922
111YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05592898
112MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05475637
113* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.05141072
114ESR1_21235772_ChIP-Seq_MCF-7_Human1.05070014
115NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04853932
116SMAD3_21741376_ChIP-Seq_HESCs_Human1.04616693
117* STAT3_23295773_ChIP-Seq_U87_Human1.03939946
118* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.03937942
119* AR_19668381_ChIP-Seq_PC3_Human1.03435405
120ERG_21242973_ChIP-ChIP_JURKAT_Human1.02198340
121* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.02184355
122* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.02096313
123TAF15_26573619_Chip-Seq_HEK293_Human1.01832551
124FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.01468821
125SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01428930
126CTNNB1_20460455_ChIP-Seq_HCT116_Human1.01257688
127ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00564052
128* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.00556004
129* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.00556004
130SALL1_21062744_ChIP-ChIP_HESCs_Human1.00088388
131GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98451298
132P53_22127205_ChIP-Seq_FIBROBLAST_Human0.97139575
133TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96792195
134ESR2_21235772_ChIP-Seq_MCF-7_Human0.96399395
135CJUN_26792858_Chip-Seq_BT549_Human0.96286260
136* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.96164095
137TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95761609
138CTBP1_25329375_ChIP-Seq_LNCAP_Human0.95218825
139SMAD3_21741376_ChIP-Seq_ESCs_Human0.93067264
140PRDM14_20953172_ChIP-Seq_ESCs_Human0.92242150
141SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.90865371
142SMAD4_21741376_ChIP-Seq_HESCs_Human0.90567560

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.63956425
2MP0005257_abnormal_intraocular_pressure3.27358783
3* MP0003635_abnormal_synaptic_transmissio3.15972613
4MP0003880_abnormal_central_pattern3.10065258
5MP0005623_abnormal_meninges_morphology2.69284780
6MP0004270_analgesia2.62255568
7MP0009745_abnormal_behavioral_response2.61527947
8MP0000569_abnormal_digit_pigmentation2.60939840
9MP0009046_muscle_twitch2.60326654
10MP0002064_seizures2.54017174
11* MP0002063_abnormal_learning/memory/cond2.53142798
12MP0004858_abnormal_nervous_system2.52331357
13MP0010368_abnormal_lymphatic_system2.50338868
14MP0010352_gastrointestinal_tract_polyps2.43271694
15MP0003690_abnormal_glial_cell2.32096784
16MP0006054_spinal_hemorrhage2.27168041
17MP0003941_abnormal_skin_development2.20644190
18MP0003279_aneurysm2.14518856
19MP0001486_abnormal_startle_reflex2.10974038
20MP0003303_peritoneal_inflammation1.98918680
21MP0003136_yellow_coat_color1.91263413
22MP0000920_abnormal_myelination1.89733089
23* MP0002572_abnormal_emotion/affect_behav1.88656772
24MP0000537_abnormal_urethra_morphology1.88511221
25MP0003075_altered_response_to1.87052023
26MP0008438_abnormal_cutaneous_collagen1.86656009
27MP0005167_abnormal_blood-brain_barrier1.85093374
28MP0005171_absent_coat_pigmentation1.82930119
29MP0001501_abnormal_sleep_pattern1.82891267
30MP0001849_ear_inflammation1.79665832
31MP0001968_abnormal_touch/_nociception1.76213233
32MP0009780_abnormal_chondrocyte_physiolo1.73806290
33MP0004885_abnormal_endolymph1.70998464
34MP0002272_abnormal_nervous_system1.69058004
35MP0001177_atelectasis1.68449110
36MP0005423_abnormal_somatic_nervous1.66803837
37MP0001958_emphysema1.66041272
38MP0000778_abnormal_nervous_system1.59606629
39MP0002734_abnormal_mechanical_nocicepti1.58790457
40MP0004510_myositis1.54927565
41MP0009053_abnormal_anal_canal1.54921737
42MP0003091_abnormal_cell_migration1.52453435
43MP0003705_abnormal_hypodermis_morpholog1.52324063
44MP0000604_amyloidosis1.50891450
45MP0003634_abnormal_glial_cell1.50297881
46MP0010030_abnormal_orbit_morphology1.49765106
47MP0001879_abnormal_lymphatic_vessel1.49693803
48MP0005595_abnormal_vascular_smooth1.48305397
49MP0001299_abnormal_eye_distance/1.48016229
50MP0005023_abnormal_wound_healing1.47244573
51MP0003329_amyloid_beta_deposits1.46744254
52MP0010234_abnormal_vibrissa_follicle1.44599727
53MP0003633_abnormal_nervous_system1.44262261
54MP0001440_abnormal_grooming_behavior1.43074534
55MP0004272_abnormal_basement_membrane1.42490227
56MP0009384_cardiac_valve_regurgitation1.39309194
57MP0004811_abnormal_neuron_physiology1.37445420
58MP0008569_lethality_at_weaning1.37350281
59MP0005508_abnormal_skeleton_morphology1.36329785
60MP0003890_abnormal_embryonic-extraembry1.35663770
61MP0002822_catalepsy1.30478320
62* MP0000432_abnormal_head_morphology1.27736704
63MP0003937_abnormal_limbs/digits/tail_de1.27226733
64MP0002067_abnormal_sensory_capabilities1.26611697
65MP0003631_nervous_system_phenotype1.25831901
66MP0000767_abnormal_smooth_muscle1.24823082
67MP0003632_abnormal_nervous_system1.19988942
68MP0002697_abnormal_eye_size1.19706253
69MP0000955_abnormal_spinal_cord1.19147816
70MP0005409_darkened_coat_color1.18050595
71MP0001293_anophthalmia1.17517191
72MP0003300_gastrointestinal_ulcer1.16405357
73MP0002736_abnormal_nociception_after1.14815515
74MP0001970_abnormal_pain_threshold1.14032052
75MP0000762_abnormal_tongue_morphology1.13683924
76MP0002090_abnormal_vision1.13642334
77MP0003453_abnormal_keratinocyte_physiol1.12221756
78MP0000343_altered_response_to1.11795297
79MP0002233_abnormal_nose_morphology1.11490227
80MP0002133_abnormal_respiratory_system1.11030652
81MP0005388_respiratory_system_phenotype1.11030652
82MP0003755_abnormal_palate_morphology1.09571134
83MP0003950_abnormal_plasma_membrane1.09482342
84MP0005197_abnormal_uvea_morphology1.09376820
85MP0005076_abnormal_cell_differentiation1.09211672
86MP0002092_abnormal_eye_morphology1.08468142
87MP0001915_intracranial_hemorrhage1.08377441
88MP0003191_abnormal_cellular_cholesterol1.07314981
89MP0005386_behavior/neurological_phenoty1.06828451
90MP0004924_abnormal_behavior1.06828451
91MP0003935_abnormal_craniofacial_develop1.06810684
92MP0002733_abnormal_thermal_nociception1.06353148
93MP0003172_abnormal_lysosome_physiology1.06099205
94MP0002882_abnormal_neuron_morphology1.04211261
95MP0005166_decreased_susceptibility_to1.04172711
96MP0005058_abnormal_lysosome_morphology1.03074100
97MP0002557_abnormal_social/conspecific_i1.01193365
98MP0010678_abnormal_skin_adnexa0.97494141
99MP0000733_abnormal_muscle_development0.97449368
100MP0002184_abnormal_innervation0.97338511
101MP0002909_abnormal_adrenal_gland0.96873667
102* MP0002066_abnormal_motor_capabilities/c0.96671987
103MP0005503_abnormal_tendon_morphology0.94765042
104MP0001542_abnormal_bone_strength0.94525455
105MP0000462_abnormal_digestive_system0.93683178
106MP0003828_pulmonary_edema0.92928355
107MP0009840_abnormal_foam_cell0.92594159
108MP0005165_increased_susceptibility_to0.92010682
109MP0000383_abnormal_hair_follicle0.91666231
110MP0002152_abnormal_brain_morphology0.91250185
111MP0000534_abnormal_ureter_morphology0.90991076
112MP0005275_abnormal_skin_tensile0.89880873
113MP0003045_fibrosis0.88954827
114MP0002060_abnormal_skin_morphology0.88563334
115MP0000049_abnormal_middle_ear0.88167844
116MP0002282_abnormal_trachea_morphology0.86624764
117MP0003385_abnormal_body_wall0.85525503
118MP0000579_abnormal_nail_morphology0.85421123
119MP0002089_abnormal_postnatal_growth/wei0.84382631
120MP0003942_abnormal_urinary_system0.84036926
121MP0005187_abnormal_penis_morphology0.83169545
122MP0002177_abnormal_outer_ear0.82204729
123MP0003283_abnormal_digestive_organ0.82060835
124MP0002116_abnormal_craniofacial_bone0.78942570
125MP0001614_abnormal_blood_vessel0.76991128
126MP0002925_abnormal_cardiovascular_devel0.76128987
127MP0002115_abnormal_skeleton_extremities0.75725914
128MP0005646_abnormal_pituitary_gland0.75532842
129MP0002998_abnormal_bone_remodeling0.74857420
130MP0000647_abnormal_sebaceous_gland0.74409951
131MP0000163_abnormal_cartilage_morphology0.73497178
132* MP0002111_abnormal_tail_morphology0.71641992
133MP0003119_abnormal_digestive_system0.70391163
134MP0004742_abnormal_vestibular_system0.70248985
135MP0010307_abnormal_tumor_latency0.69940999
136MP0003566_abnormal_cell_adhesion0.69485750
137MP0005248_abnormal_Harderian_gland0.69286469
138MP0003115_abnormal_respiratory_system0.68577185
139* MP0001943_abnormal_respiration0.68005780
140MP0005164_abnormal_response_to0.67103031
141MP0008874_decreased_physiological_sensi0.66202158
142MP0003448_altered_tumor_morphology0.65874748
143MP0002295_abnormal_pulmonary_circulatio0.65793799
144MP0004883_abnormal_blood_vessel0.65735719
145MP0004233_abnormal_muscle_weight0.65240635
146MP0002254_reproductive_system_inflammat0.65002987
147MP0009250_abnormal_appendicular_skeleto0.64956268
148MP0002877_abnormal_melanocyte_morpholog0.63845167
149MP0000751_myopathy0.63805780
150MP0001346_abnormal_lacrimal_gland0.63673642
151MP0004484_altered_response_of0.63557032
152MP0004134_abnormal_chest_morphology0.61422881
153MP0003787_abnormal_imprinting0.61228648
154MP0002108_abnormal_muscle_morphology0.60275792
155MP0000428_abnormal_craniofacial_morphol0.59676700
156MP0002896_abnormal_bone_mineralization0.58465091
157MP0002735_abnormal_chemical_nociception0.57311660

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.07413022
2Myokymia (HP:0002411)3.74551203
3Action tremor (HP:0002345)3.43204483
4Focal seizures (HP:0007359)3.38653167
5Neonatal short-limb short stature (HP:0008921)3.18378664
6Aortic dissection (HP:0002647)2.97951010
7Atrophic scars (HP:0001075)2.82482315
8Bladder diverticulum (HP:0000015)2.72657097
9Atonic seizures (HP:0010819)2.72424303
10Shallow orbits (HP:0000586)2.68518052
11Megalencephaly (HP:0001355)2.66072079
12Absent frontal sinuses (HP:0002688)2.65614292
13Supranuclear gaze palsy (HP:0000605)2.65542466
14Aplasia involving bones of the upper limbs (HP:0009823)2.56705143
15Aplasia of the phalanges of the hand (HP:0009802)2.56705143
16Aplasia involving bones of the extremities (HP:0009825)2.56705143
17Osteolytic defects of the phalanges of the hand (HP:0009771)2.54315800
18Osteolytic defects of the hand bones (HP:0009699)2.54315800
19Arterial tortuosity (HP:0005116)2.51265056
20Neurofibrillary tangles (HP:0002185)2.49862089
21Insidious onset (HP:0003587)2.47678538
22Termporal pattern (HP:0011008)2.47678538
23Papilledema (HP:0001085)2.43140177
24Progressive cerebellar ataxia (HP:0002073)2.38027124
25Epileptic encephalopathy (HP:0200134)2.36522829
26Lower limb amyotrophy (HP:0007210)2.36433797
27Cerebral inclusion bodies (HP:0100314)2.34333541
28Increased cerebral lipofuscin (HP:0011813)2.32974786
29Aortic aneurysm (HP:0004942)2.32387933
30Vascular tortuosity (HP:0004948)2.29716232
31Ankle contracture (HP:0006466)2.29234313
32Soft skin (HP:0000977)2.28518212
33Bronchomalacia (HP:0002780)2.22704981
34Genetic anticipation (HP:0003743)2.21714628
35Axonal loss (HP:0003447)2.21428563
36Aqueductal stenosis (HP:0002410)2.17608353
37Abnormality of glycolipid metabolism (HP:0010969)2.16559390
38Abnormality of liposaccharide metabolism (HP:0010968)2.16559390
39Abnormality of glycosphingolipid metabolism (HP:0004343)2.16559390
40Absence seizures (HP:0002121)2.15448515
41Inappropriate behavior (HP:0000719)2.14254123
42Visual hallucinations (HP:0002367)2.12527313
43Vertebral arch anomaly (HP:0008438)2.11522794
44Buphthalmos (HP:0000557)2.10441550
45Dysmetria (HP:0001310)2.07628259
46Broad-based gait (HP:0002136)2.07242971
47Renal duplication (HP:0000075)2.06656601
48Abnormality of dentin (HP:0010299)2.05738310
49Urinary bladder sphincter dysfunction (HP:0002839)2.05648345
50Genu recurvatum (HP:0002816)2.04325733
51Intention tremor (HP:0002080)2.04026199
52Insomnia (HP:0100785)2.02664893
53Ankyloglossia (HP:0010296)2.02656925
54Overgrowth (HP:0001548)2.02616121
55Agnosia (HP:0010524)2.02482176
56Bowel diverticulosis (HP:0005222)2.02357853
57Turricephaly (HP:0000262)2.02220498
58Hematochezia (HP:0002573)2.01796008
59Febrile seizures (HP:0002373)2.00923311
60Mutism (HP:0002300)2.00874737
61Hemiplegia (HP:0002301)1.99890085
62Generalized tonic-clonic seizures (HP:0002069)1.98813108
63Annular pancreas (HP:0001734)1.98442662
64Urethral obstruction (HP:0000796)1.98060994
65Postural instability (HP:0002172)1.97840783
66Dialeptic seizures (HP:0011146)1.96139743
67Dysdiadochokinesis (HP:0002075)1.95372282
68Cortical dysplasia (HP:0002539)1.95346364
69Abnormality of binocular vision (HP:0011514)1.94400577
70Diplopia (HP:0000651)1.94400577
71Coronal craniosynostosis (HP:0004440)1.94145724
72Nuclear cataract (HP:0100018)1.94111821
73Disinhibition (HP:0000734)1.93259330
74Overriding aorta (HP:0002623)1.92426305
75Wormian bones (HP:0002645)1.92361159
76Macroorchidism (HP:0000053)1.91496701
77Impaired vibration sensation in the lower limbs (HP:0002166)1.90547552
78Hyperacusis (HP:0010780)1.89568712
79Upper motor neuron abnormality (HP:0002127)1.89019970
80Spinal rigidity (HP:0003306)1.88951606
81Lower limb asymmetry (HP:0100559)1.87844379
82Camptodactyly of toe (HP:0001836)1.86870073
83Cerebral aneurysm (HP:0004944)1.86628085
84Pointed chin (HP:0000307)1.86464284
85Ankle clonus (HP:0011448)1.86058919
86Renovascular hypertension (HP:0100817)1.85477493
87Spinal cord lesions (HP:0100561)1.85202213
88Syringomyelia (HP:0003396)1.85202213
89Flat cornea (HP:0007720)1.84645529
90Apathy (HP:0000741)1.84066516
91Abnormality of the periventricular white matter (HP:0002518)1.83981565
92Scanning speech (HP:0002168)1.83652772
93Myocardial infarction (HP:0001658)1.83503363
94Subacute progressive viral hepatitis (HP:0006572)1.83077783
95Gaze-evoked nystagmus (HP:0000640)1.82289772
96Urinary urgency (HP:0000012)1.82233964
97Increased neuronal autofluorescent lipopigment (HP:0002074)1.82233378
98Spondylolisthesis (HP:0003302)1.82059069
99Truncal ataxia (HP:0002078)1.81664733
100Stereotypic behavior (HP:0000733)1.81420637
101Poor eye contact (HP:0000817)1.79600360
102Abnormality of the ischium (HP:0003174)1.79495613
103Premature rupture of membranes (HP:0001788)1.79400528
104Abnormality of the diencephalon (HP:0010662)1.79378489
105Excessive salivation (HP:0003781)1.79049230
106Drooling (HP:0002307)1.79049230
107Papillary thyroid carcinoma (HP:0002895)1.78976318
108Depression (HP:0000716)1.77782302
109Short 4th metacarpal (HP:0010044)1.76010030
110Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.76010030
111Hypoplasia of the iris (HP:0007676)1.75863104
112Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.75709675
113Wide anterior fontanel (HP:0000260)1.75082507
114Mitral valve prolapse (HP:0001634)1.75070065
115Preaxial foot polydactyly (HP:0001841)1.75065226
116Distal lower limb amyotrophy (HP:0008944)1.74619954
117Spastic diplegia (HP:0001264)1.74516602
118Abnormality of the frontal sinuses (HP:0002687)1.74300692
119Pulmonic stenosis (HP:0001642)1.73981882
120Ulnar bowing (HP:0003031)1.72111840
121Epiphyseal dysplasia (HP:0002656)1.71887643
122Broad metatarsal (HP:0001783)1.71315301
123Dilatation of the ascending aorta (HP:0005111)1.70842966
124Hammertoe (HP:0001765)1.70477522
125Onion bulb formation (HP:0003383)1.69731800
126Relative macrocephaly (HP:0004482)1.69204525
127Fragile skin (HP:0001030)1.69059233
128Hyperextensible skin (HP:0000974)1.68430876
129Follicular hyperkeratosis (HP:0007502)1.67988999
130Resting tremor (HP:0002322)1.67584379
131Mitral regurgitation (HP:0001653)1.67066270
132Achilles tendon contracture (HP:0001771)1.66451897
133Leiomyosarcoma (HP:0100243)1.65682524
134Uterine leiomyosarcoma (HP:0002891)1.65682524
135Obstructive sleep apnea (HP:0002870)1.65281793
136Natal tooth (HP:0000695)1.64900588
137Clumsiness (HP:0002312)1.64195388
138Abnormality of the nasal septum (HP:0000419)1.63717459
139Abnormal social behavior (HP:0012433)1.63194783
140Impaired social interactions (HP:0000735)1.63194783
141Peripheral hypomyelination (HP:0007182)1.62801258
142Absent speech (HP:0001344)1.62503626
143Diminished motivation (HP:0000745)1.62347089
144Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.61661036
145Tibial bowing (HP:0002982)1.61347732
146Elfin facies (HP:0004428)1.59665490
147Gastrointestinal carcinoma (HP:0002672)1.59634605
148Malignant gastrointestinal tract tumors (HP:0006749)1.59634605
149Abnormality of oral frenula (HP:0000190)1.59332662
150Midface retrusion (HP:0011800)1.58675266
151Arnold-Chiari malformation (HP:0002308)1.58486271
152Limited hip movement (HP:0008800)1.58314763
153Cervical subluxation (HP:0003308)1.58193785
154Large earlobe (HP:0009748)1.57539895
155Narrow palate (HP:0000189)1.57257596
156Hemiparesis (HP:0001269)1.57141306
157Dysmetric saccades (HP:0000641)1.56949807
158Cutaneous syndactyly (HP:0012725)1.56750403
159Transitional cell carcinoma of the bladder (HP:0006740)1.56555778
160Neuronal loss in central nervous system (HP:0002529)1.55570854
161Protrusio acetabuli (HP:0003179)1.54862169
162Cutaneous finger syndactyly (HP:0010554)1.54672472
163Deviation of the hallux (HP:0010051)1.54543508
164Thick nail (HP:0001805)1.54118945
165Blue sclerae (HP:0000592)1.52684607
166Tetraparesis (HP:0002273)1.51722167
167Bladder neoplasm (HP:0009725)1.51651400
168Bladder carcinoma (HP:0002862)1.51651400
169Joint laxity (HP:0001388)1.50952835
170Vertebral clefting (HP:0008428)1.50715418

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.12651688
2MAP3K93.32387038
3NTRK33.01157769
4EPHB22.90909940
5RIPK42.71169546
6TNIK2.33669218
7DAPK22.24739881
8PAK62.12324573
9KSR22.12243095
10CAMKK12.12103635
11NEK92.09937487
12NTRK12.07900714
13PRKD32.07547485
14TGFBR21.99575252
15MAP3K41.96145002
16MKNK21.90483359
17TIE11.79968979
18FGFR21.77753342
19MINK11.77641980
20MAP3K131.76467759
21DDR21.70650847
22PLK21.64967253
23CAMK1G1.61310122
24MST1R1.58949564
25BMX1.57477992
26TSSK61.56179947
27TYRO31.54371963
28PTK21.54355418
29NTRK21.53699303
30CAMKK21.49055875
31SCYL21.47773145
32PAK21.46848722
33MKNK11.45116349
34STK38L1.43772162
35FES1.42660109
36RIPK11.42250153
37CAMK1D1.41060868
38ACVR1B1.39489271
39RET1.39308195
40PAK41.34769310
41MAP3K21.34109216
42CDK51.33560205
43PDGFRA1.31744607
44KSR11.30957612
45LMTK21.24981347
46DMPK1.20995432
47MARK11.19241993
48MAP2K41.18422523
49ALK1.17287667
50WEE11.13043293
51TRIB31.12425438
52LIMK11.11863090
53TGFBR11.10307604
54WNK11.06503331
55FGR1.03358368
56STK31.02004704
57MAP2K71.01852678
58PDGFRB1.01750794
59SGK30.95375826
60MOS0.93794505
61SIK20.92416641
62SGK10.91743720
63PRKCH0.90679267
64BRSK20.90547379
65CDK60.90301444
66PTK2B0.89478967
67BCR0.89056613
68ABL20.86528129
69SGK2230.85948687
70SGK4940.85948687
71CDK190.85094375
72ICK0.84569787
73OXSR10.83041310
74AKT30.82521034
75STK390.82403361
76EPHB10.76962917
77ROCK20.76712606
78CDK140.75809010
79STK110.75652330
80PDPK10.74938876
81SGK20.74035049
82JAK10.73879523
83FER0.72771622
84FGFR10.72636931
85LATS20.72025274
86CASK0.71702474
87DAPK10.71622703
88BMPR20.70923379
89CSNK1G20.70052868
90GRK70.69751019
91EPHA20.68901699
92PDK10.68686090
93FYN0.68243515
94LATS10.65270867
95FGFR30.65250441
96CDK150.65161666
97STK380.65100010
98CSNK1A1L0.64902777
99PRKCE0.64641358
100ARAF0.63923063
101GSK3A0.63509354
102MAPK100.62794128
103CAMK2A0.61883353
104CDK180.61832126
105ERBB30.56718533
106PKN10.56412114
107YES10.56158947
108MET0.55061074
109MAP3K120.54683039
110TAF10.54581868
111STK240.54463183
112CSNK1G10.53718785
113TAOK10.52582751
114MAPKAPK50.52458941
115PRKCG0.52053885
116RPS6KA30.51954124
117ROCK10.51946678
118PTK60.51293602
119IRAK30.50507523
120SRC0.49557696
121TTK0.49438062
122CDK11A0.49424406
123RAF10.49363713
124ERBB40.48790303
125TTN0.48121553
126PAK30.46977733
127EGFR0.46536304
128RPS6KA20.45709080
129PKN20.45673226
130UHMK10.44001893
131CAMK2B0.43239437
132DAPK30.43181114
133NEK60.42835744
134MTOR0.42525207
135PNCK0.42177759
136PBK0.41017413
137CAMK40.40851632
138FRK0.40767265
139INSR0.40732271
140PRPF4B0.39775610
141EEF2K0.33769753
142CDC42BPA0.32716992
143BRD40.31509473
144CSNK1G30.31338382
145PRKG20.31151684
146PLK30.29799390
147MAP3K100.29725425

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.37254258
2Adherens junction_Homo sapiens_hsa045202.34406513
3Hippo signaling pathway_Homo sapiens_hsa043901.95417607
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.93591640
5Nicotine addiction_Homo sapiens_hsa050331.85343763
6Long-term potentiation_Homo sapiens_hsa047201.80427919
7Olfactory transduction_Homo sapiens_hsa047401.79550530
8Circadian entrainment_Homo sapiens_hsa047131.77871828
9Lysosome_Homo sapiens_hsa041421.75188613
10Glutamatergic synapse_Homo sapiens_hsa047241.74005094
11Basal cell carcinoma_Homo sapiens_hsa052171.73818511
12GABAergic synapse_Homo sapiens_hsa047271.71964809
13Synaptic vesicle cycle_Homo sapiens_hsa047211.70595526
14Morphine addiction_Homo sapiens_hsa050321.64135189
15Salivary secretion_Homo sapiens_hsa049701.61743833
16Protein digestion and absorption_Homo sapiens_hsa049741.60435325
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.56205960
18Glioma_Homo sapiens_hsa052141.48334630
19Gastric acid secretion_Homo sapiens_hsa049711.47713393
20Amphetamine addiction_Homo sapiens_hsa050311.44323010
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.44141503
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.43375569
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.42532055
24Cholinergic synapse_Homo sapiens_hsa047251.41576981
25Renin secretion_Homo sapiens_hsa049241.40053979
26Long-term depression_Homo sapiens_hsa047301.39673682
27Dopaminergic synapse_Homo sapiens_hsa047281.36650488
28Tight junction_Homo sapiens_hsa045301.35958509
29Dorso-ventral axis formation_Homo sapiens_hsa043201.34194931
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.33454390
31Oxytocin signaling pathway_Homo sapiens_hsa049211.29989358
32TGF-beta signaling pathway_Homo sapiens_hsa043501.28960055
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.27598125
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.24248622
35Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.22772936
36Wnt signaling pathway_Homo sapiens_hsa043101.22697831
37Hedgehog signaling pathway_Homo sapiens_hsa043401.16793680
38GnRH signaling pathway_Homo sapiens_hsa049121.15348487
39Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.13919356
40Gap junction_Homo sapiens_hsa045401.13433020
41Estrogen signaling pathway_Homo sapiens_hsa049151.13034245
42ErbB signaling pathway_Homo sapiens_hsa040121.12703875
43Cocaine addiction_Homo sapiens_hsa050301.12163904
44Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.11818677
45Axon guidance_Homo sapiens_hsa043601.10015028
46Phospholipase D signaling pathway_Homo sapiens_hsa040721.06154334
47Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.05754374
48Type II diabetes mellitus_Homo sapiens_hsa049301.05688288
49cAMP signaling pathway_Homo sapiens_hsa040241.04982611
50Bladder cancer_Homo sapiens_hsa052191.03721810
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.01257298
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00156793
53Central carbon metabolism in cancer_Homo sapiens_hsa052300.99908092
54Other glycan degradation_Homo sapiens_hsa005110.99313048
55Proteoglycans in cancer_Homo sapiens_hsa052050.99268046
56Renal cell carcinoma_Homo sapiens_hsa052110.98594664
57PI3K-Akt signaling pathway_Homo sapiens_hsa041510.97743820
58Neurotrophin signaling pathway_Homo sapiens_hsa047220.96880614
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96282328
60Pathways in cancer_Homo sapiens_hsa052000.96189222
61Melanogenesis_Homo sapiens_hsa049160.95760275
62Dilated cardiomyopathy_Homo sapiens_hsa054140.95342472
63Small cell lung cancer_Homo sapiens_hsa052220.95292422
64AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.94449676
65Calcium signaling pathway_Homo sapiens_hsa040200.94198069
66Focal adhesion_Homo sapiens_hsa045100.93797099
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91983622
68Steroid biosynthesis_Homo sapiens_hsa001000.91541702
69Serotonergic synapse_Homo sapiens_hsa047260.91531616
70Amoebiasis_Homo sapiens_hsa051460.90729990
71Mineral absorption_Homo sapiens_hsa049780.90277953
72Insulin secretion_Homo sapiens_hsa049110.90079306
73ECM-receptor interaction_Homo sapiens_hsa045120.90016625
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.88396770
75Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.88247073
76Osteoclast differentiation_Homo sapiens_hsa043800.88100505
77Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.87263374
78Toll-like receptor signaling pathway_Homo sapiens_hsa046200.87095703
79Rap1 signaling pathway_Homo sapiens_hsa040150.86861823
80Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.86763150
81MAPK signaling pathway_Homo sapiens_hsa040100.86379774
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86322481
83Chemokine signaling pathway_Homo sapiens_hsa040620.85390950
84African trypanosomiasis_Homo sapiens_hsa051430.85200819
85Sphingolipid metabolism_Homo sapiens_hsa006000.84721933
86Chronic myeloid leukemia_Homo sapiens_hsa052200.83281991
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.82001212
88cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81389954
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81219213
90Thyroid cancer_Homo sapiens_hsa052160.79809799
91Non-small cell lung cancer_Homo sapiens_hsa052230.79463014
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.79402542
93Salmonella infection_Homo sapiens_hsa051320.79160691
94mTOR signaling pathway_Homo sapiens_hsa041500.79094546
95Tuberculosis_Homo sapiens_hsa051520.78620942
96Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77902044
97Platelet activation_Homo sapiens_hsa046110.77772638
98TNF signaling pathway_Homo sapiens_hsa046680.76817072
99VEGF signaling pathway_Homo sapiens_hsa043700.76494262
100Endocytosis_Homo sapiens_hsa041440.75994047
101Endometrial cancer_Homo sapiens_hsa052130.75461719
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75245632
103Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.74663037
104Leishmaniasis_Homo sapiens_hsa051400.74288357
105Vitamin B6 metabolism_Homo sapiens_hsa007500.73392055
106Choline metabolism in cancer_Homo sapiens_hsa052310.72836661
107Ras signaling pathway_Homo sapiens_hsa040140.72153574
108Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71361015
109Malaria_Homo sapiens_hsa051440.71128872
110Pancreatic cancer_Homo sapiens_hsa052120.71068343
111Vibrio cholerae infection_Homo sapiens_hsa051100.70111732
112Leukocyte transendothelial migration_Homo sapiens_hsa046700.69895345
113Pertussis_Homo sapiens_hsa051330.68000858
114Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67655871
115Toxoplasmosis_Homo sapiens_hsa051450.66989009
116Melanoma_Homo sapiens_hsa052180.66883603
117Phagosome_Homo sapiens_hsa041450.66825258
118Type I diabetes mellitus_Homo sapiens_hsa049400.66640468
119Rheumatoid arthritis_Homo sapiens_hsa053230.66599095
120Prostate cancer_Homo sapiens_hsa052150.66264419
121MicroRNAs in cancer_Homo sapiens_hsa052060.66057796
122B cell receptor signaling pathway_Homo sapiens_hsa046620.65739590
123Vascular smooth muscle contraction_Homo sapiens_hsa042700.65669894
124Colorectal cancer_Homo sapiens_hsa052100.65440080
125Taste transduction_Homo sapiens_hsa047420.65009509
126Prion diseases_Homo sapiens_hsa050200.64585914
127Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63116240
128Prolactin signaling pathway_Homo sapiens_hsa049170.59661118
129Renin-angiotensin system_Homo sapiens_hsa046140.59379826
130Notch signaling pathway_Homo sapiens_hsa043300.59052297
131Thyroid hormone synthesis_Homo sapiens_hsa049180.58926734
132Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.52554314
133Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52130156
134PPAR signaling pathway_Homo sapiens_hsa033200.48661830
135HIF-1 signaling pathway_Homo sapiens_hsa040660.48559221

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