SPPL2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX metabolic process (GO:0046501)9.78892742
2protoporphyrinogen IX biosynthetic process (GO:0006782)9.17533950
3heme biosynthetic process (GO:0006783)7.73084758
4porphyrin-containing compound biosynthetic process (GO:0006779)7.58607042
5tetrapyrrole biosynthetic process (GO:0033014)6.71373220
6heme metabolic process (GO:0042168)6.24261351
7porphyrin-containing compound metabolic process (GO:0006778)6.06898126
8response to lead ion (GO:0010288)5.50978745
9response to methylmercury (GO:0051597)5.45652465
10erythrocyte maturation (GO:0043249)5.13858350
11erythrocyte development (GO:0048821)4.56248084
12motile cilium assembly (GO:0044458)4.36828548
13central nervous system myelination (GO:0022010)4.31028805
14axon ensheathment in central nervous system (GO:0032291)4.31028805
15axonemal dynein complex assembly (GO:0070286)4.30786918
16hemoglobin metabolic process (GO:0020027)4.22747447
17cilium or flagellum-dependent cell motility (GO:0001539)4.12209633
18mannose metabolic process (GO:0006013)4.12030867
19myeloid cell development (GO:0061515)3.95253293
20tetrapyrrole metabolic process (GO:0033013)3.88115789
21one-carbon compound transport (GO:0019755)3.87980733
22regulation of response to osmotic stress (GO:0047484)3.82907699
23positive regulation of histone deacetylation (GO:0031065)3.77215691
24regulation of somitogenesis (GO:0014807)3.74351495
25negative regulation of microtubule polymerization (GO:0031115)3.65753814
26negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.62433350
27negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.53507209
28acrosome reaction (GO:0007340)3.53193453
29positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.51980905
30creatine metabolic process (GO:0006600)3.51545105
31semaphorin-plexin signaling pathway (GO:0071526)3.43941641
32cytoskeletal anchoring at plasma membrane (GO:0007016)3.39408150
33erythrocyte differentiation (GO:0030218)3.38229493
34negative regulation of myotube differentiation (GO:0010832)3.38064835
35pigment biosynthetic process (GO:0046148)3.37628779
36activation of JUN kinase activity (GO:0007257)3.35025118
37protein targeting to plasma membrane (GO:0072661)3.33821471
38pentose-phosphate shunt (GO:0006098)3.33472884
39negative regulation of granulocyte differentiation (GO:0030853)3.32376873
40ensheathment of neurons (GO:0007272)3.31265732
41axon ensheathment (GO:0008366)3.31265732
42sperm motility (GO:0030317)3.29551362
43histone H4 deacetylation (GO:0070933)3.27102728
44regulation of ARF GTPase activity (GO:0032312)3.24863841
45negative regulation of inclusion body assembly (GO:0090084)3.23350096
46myelination (GO:0042552)3.19857590
47establishment of mitochondrion localization (GO:0051654)3.17414989
48apoptotic process involved in morphogenesis (GO:0060561)3.16368703
49fusion of sperm to egg plasma membrane (GO:0007342)3.15434602
50response to muramyl dipeptide (GO:0032495)3.13332391
51planar cell polarity pathway involved in neural tube closure (GO:0090179)3.13045238
52actin filament capping (GO:0051693)3.12986534
53NADPH regeneration (GO:0006740)3.12231626
54positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.11579116
55atrioventricular valve morphogenesis (GO:0003181)3.09625436
56microtubule severing (GO:0051013)3.09284634
57negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.08898460
58thymic T cell selection (GO:0045061)3.08413897
59L-serine transport (GO:0015825)3.08326450
60pyrimidine nucleobase catabolic process (GO:0006208)3.08176861
61ventricular system development (GO:0021591)3.05682530
62platelet formation (GO:0030220)3.02981618
63barbed-end actin filament capping (GO:0051016)3.02885695
64peptidyl-tyrosine autophosphorylation (GO:0038083)3.01967812
65cilium movement (GO:0003341)2.96635146
66histone H3 deacetylation (GO:0070932)2.95934301
67mitochondrial fusion (GO:0008053)2.95358399
68beta-amyloid metabolic process (GO:0050435)2.93250098
69cell volume homeostasis (GO:0006884)2.93091677
70DNA deamination (GO:0045006)2.92287485
71sodium ion export (GO:0071436)2.92279074
72response to mercury ion (GO:0046689)2.88573964
73pigment metabolic process (GO:0042440)2.87584748
74endothelial cell chemotaxis (GO:0035767)2.87567346
75cell-cell junction maintenance (GO:0045217)2.86735005
76antigen processing and presentation of endogenous antigen (GO:0019883)2.84683769
77positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.83816819
78protein autoprocessing (GO:0016540)2.83123817
79gas transport (GO:0015669)2.82900780
80activation of Rac GTPase activity (GO:0032863)2.82220170
81neuronal ion channel clustering (GO:0045161)2.82157455
82neuroblast proliferation (GO:0007405)2.81930657
83positive regulation of protein deacetylation (GO:0090312)2.81233524
84layer formation in cerebral cortex (GO:0021819)2.80134442
85negative regulation of erythrocyte differentiation (GO:0045647)2.79768449
86regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.79620017
87regulation of translational fidelity (GO:0006450)2.73856618
88positive regulation of insulin receptor signaling pathway (GO:0046628)2.73277195
89insulin-like growth factor receptor signaling pathway (GO:0048009)2.73165105
90positive thymic T cell selection (GO:0045059)2.73106975
91DNA replication initiation (GO:0006270)2.72070901
92regulation of gamma-delta T cell differentiation (GO:0045586)2.71439011
93regulation of inclusion body assembly (GO:0090083)2.70455090
94regulation of ARF protein signal transduction (GO:0032012)2.69644817
95peptidyl-cysteine modification (GO:0018198)2.69319394
96ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.68832789
97DNA unwinding involved in DNA replication (GO:0006268)2.68370209
98striated muscle atrophy (GO:0014891)2.68302093
99negative regulation of interleukin-8 production (GO:0032717)2.67718481
100negative regulation of actin filament depolymerization (GO:0030835)2.67558559
101mitochondrion transport along microtubule (GO:0047497)2.67254923
102establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.67254923
103embryonic hemopoiesis (GO:0035162)2.67167774
104cerebellar Purkinje cell layer development (GO:0021680)2.66953816
105negative regulation of viral release from host cell (GO:1902187)2.65464561
106DNA strand elongation involved in DNA replication (GO:0006271)2.65115124
107antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.63641209
108regulation of T-helper 2 cell differentiation (GO:0045628)2.63089808
109protein-DNA complex disassembly (GO:0032986)2.62083512
110nucleosome disassembly (GO:0006337)2.62083512
111Peyers patch development (GO:0048541)2.61006913
112mucosal-associated lymphoid tissue development (GO:0048537)2.61006913
113activation of MAPKKK activity (GO:0000185)2.60942907
114intracellular estrogen receptor signaling pathway (GO:0030520)2.60088795
115negative regulation of type 2 immune response (GO:0002829)2.59734816
116maternal placenta development (GO:0001893)2.59276989
117regulation of monocyte differentiation (GO:0045655)2.58944140
118histone H3-K36 demethylation (GO:0070544)2.57709474
119lysine catabolic process (GO:0006554)2.57666247
120lysine metabolic process (GO:0006553)2.57666247
121synaptic vesicle maturation (GO:0016188)2.56623279
122negative regulation of cell size (GO:0045792)2.55026577
123cellular hyperosmotic response (GO:0071474)2.54336336
124histone lysine demethylation (GO:0070076)2.53672550
125aspartate family amino acid catabolic process (GO:0009068)2.53606148
126cellular response to virus (GO:0098586)2.52828565
127progesterone metabolic process (GO:0042448)2.52579189
128negative thymic T cell selection (GO:0045060)2.51980949
129positive regulation of protein kinase C signaling (GO:0090037)2.51957581
130serine transport (GO:0032329)2.51622245
131sperm capacitation (GO:0048240)2.50096802
132regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.49800795
133germinal center formation (GO:0002467)2.49551761
134protein retention in ER lumen (GO:0006621)2.49353659
135antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.49048010
136cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.48550711
137response to insecticide (GO:0017085)2.48463395
138negative regulation of protein polymerization (GO:0032272)2.48224786
139osteoblast development (GO:0002076)2.47565359
140venous blood vessel morphogenesis (GO:0048845)2.47463062
141negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.46871808
142positive regulation of triglyceride biosynthetic process (GO:0010867)2.46391609
143sperm-egg recognition (GO:0035036)2.45884350
144positive regulation of Rap GTPase activity (GO:0032854)2.44479579
1453-UTR-mediated mRNA stabilization (GO:0070935)2.44182238
146regulation of extracellular matrix disassembly (GO:0010715)2.43693868
147regulation of hydrogen peroxide metabolic process (GO:0010310)2.43420808
148T cell selection (GO:0045058)2.42669007
149UTP metabolic process (GO:0046051)2.42335133
150binding of sperm to zona pellucida (GO:0007339)2.42311723
151establishment of nucleus localization (GO:0040023)2.41754680
152astrocyte development (GO:0014002)2.41091423
153protein polyglutamylation (GO:0018095)2.39857025
154neural tube development (GO:0021915)2.39629225
155DNA strand elongation (GO:0022616)2.39400779
156regulation of histone deacetylation (GO:0031063)2.39387019
157positive regulation of cellular response to insulin stimulus (GO:1900078)2.38705213
158regulation of gamma-delta T cell activation (GO:0046643)2.37796022
159lipopolysaccharide biosynthetic process (GO:0009103)2.37255479
160histone demethylation (GO:0016577)2.37152733
161substantia nigra development (GO:0021762)2.36538226
162mitotic G1 DNA damage checkpoint (GO:0031571)2.36324611
163NIK/NF-kappaB signaling (GO:0038061)2.33239915
164retrograde transport, endosome to Golgi (GO:0042147)2.33152518
165histone H3-K9 demethylation (GO:0033169)2.33129232
166poly(A)+ mRNA export from nucleus (GO:0016973)2.32410290
167UV protection (GO:0009650)2.31915628
168regulation of histone H3-K27 methylation (GO:0061085)2.31416881
169skeletal muscle adaptation (GO:0043501)2.31132695
170positive regulation of gamma-delta T cell activation (GO:0046645)2.30171350
171cellular extravasation (GO:0045123)2.29677776
172regulation of glucose import in response to insulin stimulus (GO:2001273)2.28146339
173regulation of cholesterol metabolic process (GO:0090181)2.27916140
174embryonic process involved in female pregnancy (GO:0060136)2.27659489
175regulation of dendritic cell antigen processing and presentation (GO:0002604)2.24857979
176positive regulation of CREB transcription factor activity (GO:0032793)2.22219172
177negative T cell selection (GO:0043383)2.21663514
178adherens junction assembly (GO:0034333)2.21309277
179lung epithelium development (GO:0060428)2.19936859
180positive regulation of Cdc42 GTPase activity (GO:0043089)2.19267889
181positive regulation of synapse maturation (GO:0090129)2.18585949
182apoptotic process involved in development (GO:1902742)2.17559566
183detection of bacterium (GO:0016045)2.16937290
184regulation of fatty acid beta-oxidation (GO:0031998)2.16407869
185G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.14858277
186positive regulation of blood vessel endothelial cell migration (GO:0043536)2.14427854
187cellular response to exogenous dsRNA (GO:0071360)2.13655805
188regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.13110624
189regulation of chemokine biosynthetic process (GO:0045073)2.12921448
190response to laminar fluid shear stress (GO:0034616)2.12540874
191cell junction maintenance (GO:0034331)2.11964168
192regulation of chromatin binding (GO:0035561)2.11583540
193diacylglycerol metabolic process (GO:0046339)2.10402144
194entrainment of circadian clock by photoperiod (GO:0043153)2.09673803

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.24767756
2VDR_21846776_ChIP-Seq_THP-1_Human2.77165803
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.66980660
4LXR_22292898_ChIP-Seq_THP-1_Human2.58321171
5ZNF263_19887448_ChIP-Seq_K562_Human2.49223361
6TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.48426106
7TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.48346191
8SCL_19346495_ChIP-Seq_HPC-7_Human2.48332380
9GATA1_19941827_ChIP-Seq_MEL_Mouse2.44211353
10GATA1_19941826_ChIP-Seq_K562_Human2.42709723
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.33199141
12MYC_22102868_ChIP-Seq_BL_Human2.23084443
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.06726718
14TP63_17297297_ChIP-ChIP_HaCaT_Human2.06670249
15EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.06014108
16GATA1_22383799_ChIP-Seq_G1ME_Mouse2.05240647
17EZH2_22144423_ChIP-Seq_EOC_Human2.04636366
18E2F7_22180533_ChIP-Seq_HELA_Human2.00671504
19SRY_22984422_ChIP-ChIP_TESTIS_Rat1.93692726
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.91616762
21DROSHA_22980978_ChIP-Seq_HELA_Human1.90901064
22ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.88757229
23KDM2B_26808549_Chip-Seq_DND41_Human1.86748838
24KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.86570251
25TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.82565534
26ERG_21242973_ChIP-ChIP_JURKAT_Human1.79315438
27* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.79301607
28ELF1_20517297_ChIP-Seq_JURKAT_Human1.77814854
29YY1_22570637_ChIP-Seq_MALME-3M_Human1.74352136
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.73223579
31ESR2_21235772_ChIP-Seq_MCF-7_Human1.71927608
32THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.67536392
33P68_20966046_ChIP-Seq_HELA_Human1.66306688
34ZFP281_18757296_ChIP-ChIP_E14_Mouse1.65069218
35CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.59770011
36ELK3_25401928_ChIP-Seq_HUVEC_Human1.59275162
37TCF7_22412390_ChIP-Seq_EML_Mouse1.58907074
38PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.55991135
39BCL6_27268052_Chip-Seq_Bcells_Human1.54796641
40* SA1_27219007_Chip-Seq_ERYTHROID_Human1.54599949
41* RUNX1_27514584_Chip-Seq_MCF-7_Human1.51790509
42BCOR_27268052_Chip-Seq_Bcells_Human1.50171463
43DNAJC2_21179169_ChIP-ChIP_NT2_Human1.49531935
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.49020015
45CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.48587216
46UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.47801541
47KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.45691334
48RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.45371752
49KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.45349299
50TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.44973702
51TET1_21451524_ChIP-Seq_MESCs_Mouse1.43522636
52VDR_24763502_ChIP-Seq_THP-1_Human1.43107192
53GATA2_19941826_ChIP-Seq_K562_Human1.39629911
54* FOXP1_21924763_ChIP-Seq_HESCs_Human1.38383177
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.34970909
56ZFP281_27345836_Chip-Seq_ESCs_Mouse1.34346517
57EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.33831390
58* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.33786376
59CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.33747488
60SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.33427896
61THAP11_20581084_ChIP-Seq_MESCs_Mouse1.32117811
62KDM2B_26808549_Chip-Seq_K562_Human1.29585559
63CTCF_20526341_ChIP-Seq_ESCs_Human1.29516470
64SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.29412684
65GATA1_26923725_Chip-Seq_HPCs_Mouse1.28178185
66NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.27654039
67TP63_22573176_ChIP-Seq_HFKS_Human1.26558561
68CTCF_18555785_ChIP-Seq_MESCs_Mouse1.24958726
69MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.24925166
70SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.24211563
71EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.24116993
72TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.23257467
73CTCF_21964334_ChIP-Seq_BJAB-B_Human1.23214753
74CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.22461602
75UTX_26944678_Chip-Seq_JUKART_Human1.22324449
76KDM2B_26808549_Chip-Seq_JURKAT_Human1.22118322
77SMC4_20622854_ChIP-Seq_HELA_Human1.21961167
78NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.21200619
79STAT6_21828071_ChIP-Seq_BEAS2B_Human1.20317561
80ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.20265683
81RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.20201015
82CTCF_27219007_Chip-Seq_ERYTHROID_Human1.19600955
83RARB_27405468_Chip-Seq_BRAIN_Mouse1.18568916
84KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.18473078
85MAF_26560356_Chip-Seq_TH1_Human1.18212185
86PHF8_20622854_ChIP-Seq_HELA_Human1.18126851
87CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.17331682
88DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16450393
89ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.15143057
90CTCF_21964334_Chip-Seq_Bcells_Human1.14635133
91CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.14290609
92MAF_26560356_Chip-Seq_TH2_Human1.14251497
93SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14228261
94E2F1_20622854_ChIP-Seq_HELA_Human1.13459678
95MYC_18358816_ChIP-ChIP_MESCs_Mouse1.12836226
96WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.12333883
97TP53_22127205_ChIP-Seq_IMR90_Human1.11602771
98RUNX1_22412390_ChIP-Seq_EML_Mouse1.10856455
99RARB_24833708_ChIP-Seq_LIVER_Mouse1.10627487
100* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10551193
101KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10544478
102CTCF_27219007_Chip-Seq_Bcells_Human1.10393928
103* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.10135068
104RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09774288
105CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.09477211
106RACK7_27058665_Chip-Seq_MCF-7_Human1.09208218
107KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09152981
108TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08498861
109SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07978756
110DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.07612270
111IKZF1_21737484_ChIP-ChIP_HCT116_Human1.07086856
112MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.06690659
113GATA1_22025678_ChIP-Seq_K562_Human1.06519778
114BRD4_27068464_Chip-Seq_AML-cells_Mouse1.06312360
115SA1_27219007_Chip-Seq_Bcells_Human1.06141942
116SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05734649
117TET1_21490601_ChIP-Seq_MESCs_Mouse1.05727103
118PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05497271
119SPI1_20517297_ChIP-Seq_HL60_Human1.04468098
120OCT4_19829295_ChIP-Seq_ESCs_Human1.03782916
121IRF8_22096565_ChIP-ChIP_GC-B_Human1.03290637
122SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.02650262
123P300_27058665_Chip-Seq_ZR-75-30cells_Human1.02408503
124XRN2_22483619_ChIP-Seq_HELA_Human1.02152047
125CTCF_26484167_Chip-Seq_Bcells_Mouse1.01653502
126HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.01609697
127SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.99391744
128NCOR1_26117541_ChIP-Seq_K562_Human0.99160998
129NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.98345190
130SPI1_23127762_ChIP-Seq_K562_Human0.98309069
131PPARA_22158963_ChIP-Seq_LIVER_Mouse0.97753671
132MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.97622520
133CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96554406
134NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96117627
135PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.95618826
136ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.95163134
137CREB1_26743006_Chip-Seq_LNCaP_Human0.94525583

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003656_abnormal_erythrocyte_physiolo7.89754754
2MP0004147_increased_porphyrin_level6.87348121
3MP0005410_abnormal_fertilization4.05231697
4MP0006054_spinal_hemorrhage3.55047434
5MP0003329_amyloid_beta_deposits3.44292333
6MP0005409_darkened_coat_color3.14722649
7MP0005076_abnormal_cell_differentiation3.11723474
8MP0000678_abnormal_parathyroid_gland3.02012802
9MP0002249_abnormal_larynx_morphology2.92036714
10MP0000920_abnormal_myelination2.73381679
11MP0003436_decreased_susceptibility_to2.71365121
12MP0004859_abnormal_synaptic_plasticity2.54929743
13MP0003705_abnormal_hypodermis_morpholog2.39514155
14MP0005058_abnormal_lysosome_morphology2.32324867
15MP0002822_catalepsy2.29846027
16MP0008260_abnormal_autophagy2.24594254
17MP0005397_hematopoietic_system_phenotyp2.14685278
18MP0001545_abnormal_hematopoietic_system2.14685278
19MP0000604_amyloidosis2.09135050
20MP0005083_abnormal_biliary_tract2.08555572
21MP0000747_muscle_weakness1.98051455
22MP0009384_cardiac_valve_regurgitation1.94847581
23MP0003279_aneurysm1.91659244
24MP0002653_abnormal_ependyma_morphology1.89343811
25MP0003183_abnormal_peptide_metabolism1.82154733
26MP0004885_abnormal_endolymph1.76913371
27MP0001348_abnormal_lacrimal_gland1.74462516
28MP0009840_abnormal_foam_cell1.74026603
29MP0009379_abnormal_foot_pigmentation1.73423426
30MP0005360_urolithiasis1.72080031
31MP0002396_abnormal_hematopoietic_system1.68641668
32MP0005670_abnormal_white_adipose1.67627477
33MP0005666_abnormal_adipose_tissue1.62973284
34MP0003634_abnormal_glial_cell1.56420039
35MP0003698_abnormal_male_reproductive1.55336838
36MP0000566_synostosis1.52649587
37MP0002933_joint_inflammation1.47824159
38MP0000681_abnormal_thyroid_gland1.46834199
39MP0010155_abnormal_intestine_physiology1.40534182
40MP0004811_abnormal_neuron_physiology1.39046039
41MP0005375_adipose_tissue_phenotype1.38489725
42MP0002089_abnormal_postnatal_growth/wei1.37348374
43MP0003763_abnormal_thymus_physiology1.34620655
44MP0000751_myopathy1.33763640
45MP0000749_muscle_degeneration1.32934793
46MP0003635_abnormal_synaptic_transmissio1.30298056
47MP0008569_lethality_at_weaning1.30062623
48MP0005503_abnormal_tendon_morphology1.28909686
49MP0003191_abnormal_cellular_cholesterol1.26924298
50MP0000733_abnormal_muscle_development1.26906854
51MP0004270_analgesia1.26235840
52MP0005451_abnormal_body_composition1.25634206
53MP0004858_abnormal_nervous_system1.24168939
54MP0006138_congestive_heart_failure1.23963852
55MP0004381_abnormal_hair_follicle1.23903669
56MP0002229_neurodegeneration1.23218097
57MP0001929_abnormal_gametogenesis1.22181842
58MP0005647_abnormal_sex_gland1.18889931
59MP0005025_abnormal_response_to1.18681239
60MP0004947_skin_inflammation1.16732693
61MP0000955_abnormal_spinal_cord1.14917422
62MP0002272_abnormal_nervous_system1.14184651
63MP0004264_abnormal_extraembryonic_tissu1.13821311
64MP0003866_abnormal_defecation1.13640554
65MP0005636_abnormal_mineral_homeostasis1.13603992
66MP0000465_gastrointestinal_hemorrhage1.13428212
67MP0005623_abnormal_meninges_morphology1.13137971
68MP0004185_abnormal_adipocyte_glucose1.11869646
69MP0001533_abnormal_skeleton_physiology1.08622275
70MP0002932_abnormal_joint_morphology1.07910358
71MP0008770_decreased_survivor_rate1.06291047
72MP0000358_abnormal_cell_content/1.05772729
73MP0003453_abnormal_keratinocyte_physiol1.04296961
74MP0002269_muscular_atrophy1.03267109
75MP0006036_abnormal_mitochondrial_physio1.01435931
76MP0008775_abnormal_heart_ventricle1.00435811
77MP0003111_abnormal_nucleus_morphology1.00177641
78MP0002998_abnormal_bone_remodeling0.99577602
79MP0004043_abnormal_pH_regulation0.98957319
80MP0002064_seizures0.98602288
81MP0003950_abnormal_plasma_membrane0.98569566
82MP0003632_abnormal_nervous_system0.98560627
83MP0004142_abnormal_muscle_tone0.96808772
84MP0005390_skeleton_phenotype0.96712428
85MP0003690_abnormal_glial_cell0.96534172
86MP0002138_abnormal_hepatobiliary_system0.95931569
87MP0003091_abnormal_cell_migration0.95551097
88MP0002161_abnormal_fertility/fecundity0.94219139
89MP0002882_abnormal_neuron_morphology0.93487678
90MP0000467_abnormal_esophagus_morphology0.92971284
91MP0003806_abnormal_nucleotide_metabolis0.92571884
92MP0001800_abnormal_humoral_immune0.92451387
93MP0005387_immune_system_phenotype0.92077808
94MP0001790_abnormal_immune_system0.92077808
95MP0003045_fibrosis0.90297556
96MP0004510_myositis0.90244904
97MP0004808_abnormal_hematopoietic_stem0.89789265
98MP0005330_cardiomyopathy0.89597514
99MP0001664_abnormal_digestion0.87494798
100MP0004215_abnormal_myocardial_fiber0.87317114
101MP0005377_hearing/vestibular/ear_phenot0.86608543
102MP0003878_abnormal_ear_physiology0.86608543
103MP0009278_abnormal_bone_marrow0.86501736
104MP0004130_abnormal_muscle_cell0.85646654
105MP0001485_abnormal_pinna_reflex0.85048238
106MP0001502_abnormal_circadian_rhythm0.84690322
107MP0000013_abnormal_adipose_tissue0.84186464
108MP0002152_abnormal_brain_morphology0.84153427
109MP0002419_abnormal_innate_immunity0.82845334
110MP0003075_altered_response_to0.82024394
111MP0002796_impaired_skin_barrier0.81912199
112MP0001873_stomach_inflammation0.81636968
113MP0004134_abnormal_chest_morphology0.81360066
114MP0003631_nervous_system_phenotype0.81077228
115MP0002066_abnormal_motor_capabilities/c0.80837937
116MP0000477_abnormal_intestine_morphology0.80425076
117MP0001730_embryonic_growth_arrest0.80296218
118MP0005000_abnormal_immune_tolerance0.80150809
119MP0000778_abnormal_nervous_system0.79845922
120MP0003172_abnormal_lysosome_physiology0.79689025
121MP0002971_abnormal_brown_adipose0.79311232
122MP0001765_abnormal_ion_homeostasis0.78774648
123MP0000685_abnormal_immune_system0.78342278
124MP0000003_abnormal_adipose_tissue0.77569127
125MP0002116_abnormal_craniofacial_bone0.77025661
126MP0002063_abnormal_learning/memory/cond0.76783179
127MP0009745_abnormal_behavioral_response0.76679988
128MP0002420_abnormal_adaptive_immunity0.75773711
129MP0001819_abnormal_immune_cell0.75361322
130MP0001486_abnormal_startle_reflex0.75255332
131MP0002405_respiratory_system_inflammati0.75241462
132MP0004782_abnormal_surfactant_physiolog0.74747413
133MP0005584_abnormal_enzyme/coenzyme_acti0.74270288
134MP0005508_abnormal_skeleton_morphology0.74121861
135MP0001440_abnormal_grooming_behavior0.74034628
136MP0002132_abnormal_respiratory_system0.73305883
137MP0004233_abnormal_muscle_weight0.73157365
138MP0002160_abnormal_reproductive_system0.73076378
139MP0009333_abnormal_splenocyte_physiolog0.72553345
140MP0003633_abnormal_nervous_system0.72465920
141MP0009115_abnormal_fat_cell0.72403698
142MP0000767_abnormal_smooth_muscle0.71990992
143MP0002970_abnormal_white_adipose0.71774288
144MP0000249_abnormal_blood_vessel0.71309043
145MP0003948_abnormal_gas_homeostasis0.71176516
146MP0005381_digestive/alimentary_phenotyp0.70401349
147MP0000759_abnormal_skeletal_muscle0.70288805
148MP0001835_abnormal_antigen_presentation0.70189494
149MP0001663_abnormal_digestive_system0.69049380
150MP0002398_abnormal_bone_marrow0.68362749
151MP0005551_abnormal_eye_electrophysiolog0.67795664
152MP0004742_abnormal_vestibular_system0.67653377
153MP0005464_abnormal_platelet_physiology0.66624643
154MP0003861_abnormal_nervous_system0.65897606
155MP0001851_eye_inflammation0.64774159
156MP0003300_gastrointestinal_ulcer0.64041443
157MP0001849_ear_inflammation0.63957412
158MP0003879_abnormal_hair_cell0.63645308
159MP0005423_abnormal_somatic_nervous0.63568569
160MP0003303_peritoneal_inflammation0.63389611
161MP0002734_abnormal_mechanical_nocicepti0.62991839
162MP0004145_abnormal_muscle_electrophysio0.62983392
163MP0001958_emphysema0.62636649
164MP0001529_abnormal_vocalization0.61317238
165MP0000462_abnormal_digestive_system0.61313448
166MP0002080_prenatal_lethality0.61091316
167MP0010030_abnormal_orbit_morphology0.58894566
168MP0002722_abnormal_immune_system0.57877092
169MP0009931_abnormal_skin_appearance0.57655879
170MP0001145_abnormal_male_reproductive0.57099357
171MP0000689_abnormal_spleen_morphology0.57032366
172MP0004087_abnormal_muscle_fiber0.56644982

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the heme biosynthetic pathway (HP:0010472)8.70039327
2Poikilocytosis (HP:0004447)6.12746062
3Reticulocytosis (HP:0001923)5.38173853
4Insomnia (HP:0100785)4.80542914
5Obstructive sleep apnea (HP:0002870)4.58329518
6Acanthocytosis (HP:0001927)4.58120707
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.08223444
8Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.05417443
9Degeneration of the lateral corticospinal tracts (HP:0002314)4.05417443
10Abnormal number of erythroid precursors (HP:0012131)3.97250867
11Abnormal gallbladder physiology (HP:0012438)3.73105449
12Cholecystitis (HP:0001082)3.73105449
13Nasal polyposis (HP:0100582)3.63927501
14Abnormality of cells of the erythroid lineage (HP:0012130)3.61390091
15J-shaped sella turcica (HP:0002680)3.60924394
16Abnormal respiratory motile cilium physiology (HP:0012261)3.57406822
17Hyperbilirubinemia (HP:0002904)3.55346002
18Cholelithiasis (HP:0001081)3.52777519
19Diaphragmatic weakness (HP:0009113)3.52031998
20Abnormality of the corticospinal tract (HP:0002492)3.43496855
21Broad face (HP:0000283)3.42914666
22Stridor (HP:0010307)3.35105884
23Back pain (HP:0003418)3.34470952
24Abnormality of reticulocytes (HP:0004312)3.31441980
25Neurofibrillary tangles (HP:0002185)3.29687012
26Cerebral aneurysm (HP:0004944)3.25014243
27Absent/shortened dynein arms (HP:0200106)3.23132903
28Dynein arm defect of respiratory motile cilia (HP:0012255)3.23132903
29Abnormality of the nasal mucosa (HP:0000433)3.20199798
30Cerebral inclusion bodies (HP:0100314)3.19189251
31Rhinitis (HP:0012384)3.18435062
32Abnormal gallbladder morphology (HP:0012437)3.13967295
33Insidious onset (HP:0003587)3.12713253
34Termporal pattern (HP:0011008)3.12713253
35Thoracic kyphosis (HP:0002942)3.09741579
36Supranuclear gaze palsy (HP:0000605)3.07615602
37Abnormal respiratory epithelium morphology (HP:0012253)3.04460974
38Abnormal respiratory motile cilium morphology (HP:0005938)3.04460974
39Lymphangioma (HP:0100764)3.00926657
40Abnormality of the fingertips (HP:0001211)2.95800949
41Abnormality of the thoracic spine (HP:0100711)2.93172808
42Spastic gait (HP:0002064)2.88976681
43Cerebral hypomyelination (HP:0006808)2.88121001
44Atelectasis (HP:0100750)2.82969455
45Abnormality of the lower motor neuron (HP:0002366)2.82763043
46Thin bony cortex (HP:0002753)2.81563335
47Cervical subluxation (HP:0003308)2.80782294
48Male infertility (HP:0003251)2.75346557
49Petechiae (HP:0000967)2.75312727
50Hemorrhage of the eye (HP:0011885)2.74909534
51Abnormal ciliary motility (HP:0012262)2.74468172
52Amyotrophic lateral sclerosis (HP:0007354)2.72688836
53Peripheral hypomyelination (HP:0007182)2.72487913
54Ankle clonus (HP:0011448)2.63437966
55Oral leukoplakia (HP:0002745)2.62581840
56Flat acetabular roof (HP:0003180)2.62249157
57Myokymia (HP:0002411)2.55787970
58Chronic bronchitis (HP:0004469)2.54454378
59Ileus (HP:0002595)2.52884488
60Polycythemia (HP:0001901)2.49432939
61Aortic regurgitation (HP:0001659)2.48551981
62Increased IgE level (HP:0003212)2.41924030
63Broad distal phalanx of finger (HP:0009836)2.40231632
64Urinary urgency (HP:0000012)2.32876157
65Colitis (HP:0002583)2.31803048
66Shallow orbits (HP:0000586)2.31270394
67Increased serum ferritin (HP:0003281)2.31244318
68Dysostosis multiplex (HP:0000943)2.30296936
69Cellulitis (HP:0100658)2.28361924
70Paralysis (HP:0003470)2.26230053
71Hyperacusis (HP:0010780)2.24942603
72Mucopolysacchariduria (HP:0008155)2.24653320
73Urinary glycosaminoglycan excretion (HP:0003541)2.24653320
74Joint stiffness (HP:0001387)2.21906304
75Myopathic facies (HP:0002058)2.19998548
76Depression (HP:0000716)2.19270447
77Bronchomalacia (HP:0002780)2.18463361
78Rectal prolapse (HP:0002035)2.15374318
79Malnutrition (HP:0004395)2.15107573
80Broad metatarsal (HP:0001783)2.14965017
81Abnormality of the gallbladder (HP:0005264)2.14672441
82Difficulty running (HP:0009046)2.12124598
83Annular pancreas (HP:0001734)2.11681915
84Protrusio acetabuli (HP:0003179)2.11225882
85Anomalous pulmonary venous return (HP:0010772)2.10569217
86Spastic tetraparesis (HP:0001285)2.08676600
87Overriding aorta (HP:0002623)2.07773373
88Metaphyseal cupping (HP:0003021)2.07359441
89Gastrointestinal inflammation (HP:0004386)2.06932043
90Achilles tendon contracture (HP:0001771)2.06696063
91Abnormality of mucopolysaccharide metabolism (HP:0011020)2.05568205
92Abnormality of polysaccharide metabolism (HP:0011012)2.05568205
93Abnormality of glycosaminoglycan metabolism (HP:0004371)2.05568205
94Asplenia (HP:0001746)2.04560377
95Delusions (HP:0000746)2.04125952
96Eczematoid dermatitis (HP:0000976)2.03550993
97Abnormality of the aortic arch (HP:0012303)2.02648312
98Easy fatigability (HP:0003388)2.01953769
99Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.01699756
100Absent epiphyses (HP:0010577)2.01699756
101Emphysema (HP:0002097)2.01682839
102Spastic paraparesis (HP:0002313)2.00932141
103Mitral regurgitation (HP:0001653)2.00882414
104Megalencephaly (HP:0001355)1.99839830
105Increased connective tissue (HP:0009025)1.99478940
106Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.98978615
107Hand muscle atrophy (HP:0009130)1.98867265
108Ulnar bowing (HP:0003031)1.98002630
109Hypoplasia of the brainstem (HP:0002365)1.95287487
110Aplasia/Hypoplasia of the brainstem (HP:0007362)1.95287487
111Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.95207795
112Infertility (HP:0000789)1.95085435
113Aneurysm (HP:0002617)1.92511437
114Polygenic inheritance (HP:0010982)1.90947350
115Distal lower limb amyotrophy (HP:0008944)1.90152054
116Abnormality of the Achilles tendon (HP:0005109)1.89558627
117Difficulty climbing stairs (HP:0003551)1.88793924
118Intention tremor (HP:0002080)1.88248905
119Hypoplasia of the capital femoral epiphysis (HP:0003090)1.86941872
120Abnormality of the odontoid process (HP:0003310)1.86834141
121Hypercortisolism (HP:0001578)1.85532739
122Vertebral arch anomaly (HP:0008438)1.85220065
123Type II lissencephaly (HP:0007260)1.84534676
124Increased variability in muscle fiber diameter (HP:0003557)1.83038992
125Spinal canal stenosis (HP:0003416)1.81472828
126Genetic anticipation (HP:0003743)1.80970500
127Centrally nucleated skeletal muscle fibers (HP:0003687)1.80509675
128Abnormality of the pulmonary veins (HP:0011718)1.80348362
129Exercise-induced myalgia (HP:0003738)1.79627833
130Aplasia/Hypoplasia of the spleen (HP:0010451)1.79587119
131Bell-shaped thorax (HP:0001591)1.79368934
132Spinal cord lesions (HP:0100561)1.79050397
133Syringomyelia (HP:0003396)1.79050397
134Disproportionate tall stature (HP:0001519)1.76843504
135Neoplasm of the heart (HP:0100544)1.75560564
136Abnormality of iron homeostasis (HP:0011031)1.74852484
137Akinesia (HP:0002304)1.73982991
138Mildly elevated creatine phosphokinase (HP:0008180)1.73101515
139Lissencephaly (HP:0001339)1.72844576
140Cerebellar dysplasia (HP:0007033)1.72450824
141Slow saccadic eye movements (HP:0000514)1.72376011
142Abnormality of the columella (HP:0009929)1.71403406
143Onion bulb formation (HP:0003383)1.71013530
144Global brain atrophy (HP:0002283)1.70457049
145Gingivitis (HP:0000230)1.70050925
146Progressive microcephaly (HP:0000253)1.70041485
147Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.69810854
148Abnormality of the intervertebral disk (HP:0005108)1.69758253
149Irregular epiphyses (HP:0010582)1.68986729
150Hypertriglyceridemia (HP:0002155)1.68856847
151Long palpebral fissure (HP:0000637)1.68002537
152Asymmetric septal hypertrophy (HP:0001670)1.67783917
153Apathy (HP:0000741)1.67193385
154Severe muscular hypotonia (HP:0006829)1.67099140
155Turricephaly (HP:0000262)1.67022375
156Cerebellar hypoplasia (HP:0001321)1.66752590
157Inflammation of the large intestine (HP:0002037)1.66672192
158Urethral obstruction (HP:0000796)1.66663898
159Agammaglobulinemia (HP:0004432)1.66605600
160Increased neuronal autofluorescent lipopigment (HP:0002074)1.66584205
161Seborrheic dermatitis (HP:0001051)1.66448334
162Visual hallucinations (HP:0002367)1.65464760
163Abnormal vertebral ossification (HP:0100569)1.64621334
164Impaired vibration sensation in the lower limbs (HP:0002166)1.64303883
165Nonimmune hydrops fetalis (HP:0001790)1.63947176
166Pointed chin (HP:0000307)1.63653222
167Thrombocytosis (HP:0001894)1.63548650
168Self-mutilation (HP:0000742)1.62928495
169Increased cerebral lipofuscin (HP:0011813)1.62301413
170Absent rod-and cone-mediated responses on ERG (HP:0007688)1.61315126
171Postural instability (HP:0002172)1.60759036
172Growth hormone excess (HP:0000845)1.60354774
173Lower limb muscle weakness (HP:0007340)1.58712315
174Abnormality of the distal phalanx of the thumb (HP:0009617)1.58580147
175Diminished motivation (HP:0000745)1.58533752
176Abnormal auditory evoked potentials (HP:0006958)1.58186059
177Impaired smooth pursuit (HP:0007772)1.57832406
178Deformed sella turcica (HP:0002681)1.57453708
179Long eyelashes (HP:0000527)1.56826276
180Flattened epiphyses (HP:0003071)1.56449520
181Visceral angiomatosis (HP:0100761)1.55942951
182Polymicrogyria (HP:0002126)1.55564133
183Distal upper limb amyotrophy (HP:0007149)1.54169413
184Upper limb amyotrophy (HP:0009129)1.54169413
185Cutaneous photosensitivity (HP:0000992)1.53801772
186CNS hypomyelination (HP:0003429)1.53343067
187Atrophy/Degeneration involving motor neurons (HP:0007373)1.53251200
188Megalocornea (HP:0000485)1.52373104

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK3.96850943
2EEF2K3.85504946
3TRIB32.84484583
4PRPF4B2.71334674
5RIPK12.49002711
6BLK2.43783115
7CDK192.25831276
8TESK12.25486960
9TESK22.20179358
10SMG12.09411532
11STK391.98230069
12EPHB11.95472207
13SCYL21.94960764
14ERN11.93355084
15MAP3K101.90708782
16TNK21.81945406
17PRKD31.78185402
18CDK121.74828119
19MAP2K31.74403011
20EPHA21.68743650
21MAP3K71.63931147
22PKN21.61103323
23MARK11.61046180
24MAP3K61.60314619
25EIF2AK11.60120830
26MAP4K11.59528278
27MST1R1.55295381
28FGFR41.54409593
29UHMK11.53667411
30DYRK31.51656199
31MAPKAPK51.49141608
32CDC42BPA1.46783889
33TNIK1.45334481
34KDR1.36981708
35DYRK1B1.36244374
36PAK61.35965589
37PRKD21.35024141
38PTK2B1.31494254
39TAOK11.31367289
40WNK41.29982891
41MAP3K111.28283975
42RPS6KC11.24724721
43RPS6KL11.24724721
44CDC71.23145239
45SIK21.23122129
46CDK151.17038507
47CLK11.15692341
48ZAP701.14056625
49CDK11A1.13693194
50MAP3K131.12784969
51DAPK21.11622640
52CDK181.09748246
53CDK141.09523732
54NTRK11.05906850
55RPS6KA61.05812150
56NEK21.03139702
57MAP3K31.02549462
58LRRK20.99125768
59SIK10.98340181
60RIPK40.98149574
61MAP2K60.97382964
62TYK20.94220609
63BMX0.94181546
64MINK10.93421167
65BRSK10.93255436
66PDK40.91714180
67PDK30.91714180
68MAPK70.91512365
69NME20.88846305
70PAK20.85606687
71CDK50.84811025
72MAPKAPK30.84527495
73IRAK30.83657963
74PIM20.82151733
75BTK0.82081503
76GRK60.81837838
77OXSR10.81633158
78MAP3K10.81419648
79NTRK20.81374167
80TTN0.81144404
81CAMKK10.80477188
82MAP2K20.80206985
83PDGFRA0.79438755
84LMTK20.78560879
85MAPK120.74938713
86DYRK20.74765058
87PHKG20.74511072
88PHKG10.74511072
89ROCK20.72007617
90MET0.71982094
91CSNK1G30.71946138
92IRAK40.71436759
93PAK10.70897770
94MARK20.70381831
95MAPK110.69030839
96MAPK150.68972229
97STK100.68054845
98MAP3K80.67703986
99TBK10.67413437
100JAK30.67168353
101LIMK10.67056937
102TLK10.63228779
103TYRO30.63071009
104PAK40.62503444
105CSNK1A1L0.61823647
106AURKA0.61689663
107PKN10.61093788
108MAPK40.59780237
109RPS6KA20.59482768
110CDK40.58723474
111DDR20.57875293
112KSR20.56432415
113HCK0.55725212
114CDK60.55709156
115MAPK130.54537729
116STK380.53104213
117FYN0.52269466
118IKBKE0.51861881
119CSF1R0.51592833
120CAMK40.51179311
121ERBB20.50798417
122CDK90.49966214
123PTK20.49715686
124RET0.49504142
125ITK0.49158274
126PRKCH0.49073162
127FES0.48867997
128CSK0.48787027
129PNCK0.48705152
130SYK0.48445705
131KIT0.48033910
132CHUK0.47313928
133NEK10.47018987
134PRKG20.46386462
135MAPK80.46370793
136PDPK10.46258668
137PDK10.46185591
138HIPK20.45837017
139STK40.45821301
140STK160.45373549
141RPS6KA10.45358937
142JAK20.44880410
143PRKAA10.44763059
144FLT30.43690896
145MAPK30.43676593
146MTOR0.43260376
147RPS6KB20.42181104
148PTK60.41697290
149BCKDK0.41225210
150CSNK1G20.40812465
151MATK0.40723559
152PRKCG0.40575835
153PAK30.39657665
154IRAK20.39623339
155PRKD10.38791545
156PRKAA20.38191057
157MAPK10.37278540
158MAP3K140.36611255

Predicted pathways (KEGG)

RankGene SetZ-score
1Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008605.08913658
2DNA replication_Homo sapiens_hsa030303.42514004
3Other glycan degradation_Homo sapiens_hsa005113.17275862
4Sulfur relay system_Homo sapiens_hsa041222.42926058
5Systemic lupus erythematosus_Homo sapiens_hsa053222.26980009
6Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.92955880
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.91976311
8Alcoholism_Homo sapiens_hsa050341.90793701
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.77270626
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.74144500
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.71798273
12Vitamin B6 metabolism_Homo sapiens_hsa007501.71044322
13Glycosaminoglycan degradation_Homo sapiens_hsa005311.67723338
14Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.62823968
15Base excision repair_Homo sapiens_hsa034101.60324350
16Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.53499604
17Pyruvate metabolism_Homo sapiens_hsa006201.53177809
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.50425572
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.48963473
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.43914786
21Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.41179913
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.36337253
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.36133798
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.34824056
25Choline metabolism in cancer_Homo sapiens_hsa052311.31919620
26VEGF signaling pathway_Homo sapiens_hsa043701.31046575
27Chronic myeloid leukemia_Homo sapiens_hsa052201.25688507
28GnRH signaling pathway_Homo sapiens_hsa049121.24440162
29Phosphatidylinositol signaling system_Homo sapiens_hsa040701.23592013
30Axon guidance_Homo sapiens_hsa043601.22911415
31Biosynthesis of amino acids_Homo sapiens_hsa012301.20597996
32Glycerophospholipid metabolism_Homo sapiens_hsa005641.19490269
33mTOR signaling pathway_Homo sapiens_hsa041501.19308771
34Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.15146967
35Osteoclast differentiation_Homo sapiens_hsa043801.14813905
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.14304959
37Pentose phosphate pathway_Homo sapiens_hsa000301.13607182
38Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.10689649
39Carbon metabolism_Homo sapiens_hsa012001.10012358
40Leishmaniasis_Homo sapiens_hsa051401.09935861
41Mismatch repair_Homo sapiens_hsa034301.08233169
42Spliceosome_Homo sapiens_hsa030401.08217204
43Fatty acid biosynthesis_Homo sapiens_hsa000611.07398981
44Endocytosis_Homo sapiens_hsa041441.06558134
45Fructose and mannose metabolism_Homo sapiens_hsa000511.06150957
46N-Glycan biosynthesis_Homo sapiens_hsa005101.03389589
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.03088333
48Thyroid hormone signaling pathway_Homo sapiens_hsa049191.02870993
49Carbohydrate digestion and absorption_Homo sapiens_hsa049731.02520858
50Central carbon metabolism in cancer_Homo sapiens_hsa052301.02304868
51Cardiac muscle contraction_Homo sapiens_hsa042601.02046499
52Hepatitis C_Homo sapiens_hsa051601.01955632
53Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.00853586
54Longevity regulating pathway - mammal_Homo sapiens_hsa042110.99827530
55Bladder cancer_Homo sapiens_hsa052190.98979970
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.98612470
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.98609371
58B cell receptor signaling pathway_Homo sapiens_hsa046620.97736253
59ErbB signaling pathway_Homo sapiens_hsa040120.97216576
60Olfactory transduction_Homo sapiens_hsa047400.95159256
61Insulin resistance_Homo sapiens_hsa049310.94620195
62Prolactin signaling pathway_Homo sapiens_hsa049170.94198933
63Inositol phosphate metabolism_Homo sapiens_hsa005620.94080896
64Nucleotide excision repair_Homo sapiens_hsa034200.92802889
65Non-small cell lung cancer_Homo sapiens_hsa052230.92129560
66Glioma_Homo sapiens_hsa052140.91234099
67Insulin signaling pathway_Homo sapiens_hsa049100.91222175
68Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.91097465
69Endometrial cancer_Homo sapiens_hsa052130.90881261
70Lysine degradation_Homo sapiens_hsa003100.90484558
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.90433950
72Selenocompound metabolism_Homo sapiens_hsa004500.90231958
73Parkinsons disease_Homo sapiens_hsa050120.89727454
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89725946
75Oocyte meiosis_Homo sapiens_hsa041140.89712958
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.89020347
77TNF signaling pathway_Homo sapiens_hsa046680.87883714
78RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.87337492
79Viral carcinogenesis_Homo sapiens_hsa052030.86953199
80Influenza A_Homo sapiens_hsa051640.86292960
81Pyrimidine metabolism_Homo sapiens_hsa002400.86280613
82Dorso-ventral axis formation_Homo sapiens_hsa043200.85027423
83Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.84312729
84Toxoplasmosis_Homo sapiens_hsa051450.82988417
85Bile secretion_Homo sapiens_hsa049760.82687758
86T cell receptor signaling pathway_Homo sapiens_hsa046600.81051270
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.79559589
88Pancreatic cancer_Homo sapiens_hsa052120.79328789
89Intestinal immune network for IgA production_Homo sapiens_hsa046720.78578929
90Synaptic vesicle cycle_Homo sapiens_hsa047210.77662880
91Gap junction_Homo sapiens_hsa045400.77119546
92Notch signaling pathway_Homo sapiens_hsa043300.76995677
93Amoebiasis_Homo sapiens_hsa051460.75840882
94Renal cell carcinoma_Homo sapiens_hsa052110.75805888
95Gastric acid secretion_Homo sapiens_hsa049710.74520193
96Huntingtons disease_Homo sapiens_hsa050160.74061071
97Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73335377
98Toll-like receptor signaling pathway_Homo sapiens_hsa046200.72432580
99Staphylococcus aureus infection_Homo sapiens_hsa051500.71743566
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.71347214
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.69095543
102Arginine and proline metabolism_Homo sapiens_hsa003300.68371202
103Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.67780742
104Focal adhesion_Homo sapiens_hsa045100.67761398
105Melanogenesis_Homo sapiens_hsa049160.67089453
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.67065800
107Circadian entrainment_Homo sapiens_hsa047130.66615876
108Estrogen signaling pathway_Homo sapiens_hsa049150.66440454
109NF-kappa B signaling pathway_Homo sapiens_hsa040640.66328599
110Salivary secretion_Homo sapiens_hsa049700.65956690
111MAPK signaling pathway_Homo sapiens_hsa040100.65800284
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.65244210
113Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.65000724
114Dopaminergic synapse_Homo sapiens_hsa047280.64926829
115Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64758772
116Vitamin digestion and absorption_Homo sapiens_hsa049770.63419277
117Nitrogen metabolism_Homo sapiens_hsa009100.63106380
118Fatty acid metabolism_Homo sapiens_hsa012120.62926423
119Long-term potentiation_Homo sapiens_hsa047200.62364491
120Alzheimers disease_Homo sapiens_hsa050100.62276324
121Shigellosis_Homo sapiens_hsa051310.62223511
122Glutamatergic synapse_Homo sapiens_hsa047240.60885645
123HTLV-I infection_Homo sapiens_hsa051660.59036048
124Rap1 signaling pathway_Homo sapiens_hsa040150.59008209
125Glutathione metabolism_Homo sapiens_hsa004800.58831675
126Hepatitis B_Homo sapiens_hsa051610.58022952
127Glycerolipid metabolism_Homo sapiens_hsa005610.56971855
128Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55272999
129Chemokine signaling pathway_Homo sapiens_hsa040620.54899928
130Galactose metabolism_Homo sapiens_hsa000520.54845393
131ECM-receptor interaction_Homo sapiens_hsa045120.54811866
132Tuberculosis_Homo sapiens_hsa051520.54155441
133Acute myeloid leukemia_Homo sapiens_hsa052210.54139916
134Jak-STAT signaling pathway_Homo sapiens_hsa046300.53813064
135Fatty acid degradation_Homo sapiens_hsa000710.52950957
136Type II diabetes mellitus_Homo sapiens_hsa049300.51720705
137Arginine biosynthesis_Homo sapiens_hsa002200.51231249
138Protein digestion and absorption_Homo sapiens_hsa049740.50588508
139Fat digestion and absorption_Homo sapiens_hsa049750.50557501
140Herpes simplex infection_Homo sapiens_hsa051680.50381768
141Cholinergic synapse_Homo sapiens_hsa047250.49832098
142Apoptosis_Homo sapiens_hsa042100.49674119
143Vascular smooth muscle contraction_Homo sapiens_hsa042700.49608927
144AMPK signaling pathway_Homo sapiens_hsa041520.49337260
145Neurotrophin signaling pathway_Homo sapiens_hsa047220.49062253
146Steroid biosynthesis_Homo sapiens_hsa001000.48614728
147Propanoate metabolism_Homo sapiens_hsa006400.48469176
148ABC transporters_Homo sapiens_hsa020100.47369832
149Renin-angiotensin system_Homo sapiens_hsa046140.46977637
150Fatty acid elongation_Homo sapiens_hsa000620.46911318
151Aldosterone synthesis and secretion_Homo sapiens_hsa049250.46729509
152Primary immunodeficiency_Homo sapiens_hsa053400.46597283
153Colorectal cancer_Homo sapiens_hsa052100.46387679
154Platelet activation_Homo sapiens_hsa046110.45409511
155Allograft rejection_Homo sapiens_hsa053300.45047101
156GABAergic synapse_Homo sapiens_hsa047270.42761089
157Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.40831508
158Cyanoamino acid metabolism_Homo sapiens_hsa004600.40095730
159Cell cycle_Homo sapiens_hsa041100.40007319
160Sulfur metabolism_Homo sapiens_hsa009200.39393521
161Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39205022
162Purine metabolism_Homo sapiens_hsa002300.37455067
163PPAR signaling pathway_Homo sapiens_hsa033200.35506308

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