SPOP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of cilium movement (GO:0003352)4.54477759
2gamma-aminobutyric acid transport (GO:0015812)4.49734858
3protein-cofactor linkage (GO:0018065)4.39506522
4epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.32879637
5adaptation of signaling pathway (GO:0023058)4.30661407
6DNA deamination (GO:0045006)4.13445382
7behavioral response to nicotine (GO:0035095)4.04911777
8water-soluble vitamin biosynthetic process (GO:0042364)3.80607119
9epithelial cilium movement (GO:0003351)3.65638698
10sequestering of actin monomers (GO:0042989)3.64283195
11artery smooth muscle contraction (GO:0014824)3.63595421
12negative regulation of oligodendrocyte differentiation (GO:0048715)3.59237225
13protein complex biogenesis (GO:0070271)3.56526525
14respiratory chain complex IV assembly (GO:0008535)3.49088607
15regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.41869714
16axoneme assembly (GO:0035082)3.37680712
17synaptic vesicle maturation (GO:0016188)3.36588285
18mitochondrial respiratory chain complex assembly (GO:0033108)3.32879696
19mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.31724675
20negative regulation of astrocyte differentiation (GO:0048712)3.30251295
21tonic smooth muscle contraction (GO:0014820)3.28767855
22mitochondrial respiratory chain complex I assembly (GO:0032981)3.25534753
23NADH dehydrogenase complex assembly (GO:0010257)3.25534753
24mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.25534753
25serotonin receptor signaling pathway (GO:0007210)3.24721832
26ATP synthesis coupled proton transport (GO:0015986)3.18776304
27energy coupled proton transport, down electrochemical gradient (GO:0015985)3.18776304
28urinary tract smooth muscle contraction (GO:0014848)3.16905864
29polyketide metabolic process (GO:0030638)3.16196106
30doxorubicin metabolic process (GO:0044598)3.16196106
31daunorubicin metabolic process (GO:0044597)3.16196106
32cytochrome complex assembly (GO:0017004)3.13155372
33cellular ketone body metabolic process (GO:0046950)3.12206483
34regulation of dopamine secretion (GO:0014059)3.10384645
35positive regulation of catecholamine secretion (GO:0033605)3.02440055
36tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.99481552
37RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.99481552
38preassembly of GPI anchor in ER membrane (GO:0016254)2.98357834
39vascular smooth muscle contraction (GO:0014829)2.98302858
40G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.96486892
41cytidine deamination (GO:0009972)2.95789453
42cytidine metabolic process (GO:0046087)2.95789453
43cytidine catabolic process (GO:0006216)2.95789453
44protein polyglutamylation (GO:0018095)2.95679630
45regulation of glucokinase activity (GO:0033131)2.95096015
46regulation of hexokinase activity (GO:1903299)2.95096015
47regulation of microtubule-based movement (GO:0060632)2.94332579
48positive regulation of glycolytic process (GO:0045821)2.93703328
49ketone body metabolic process (GO:1902224)2.93119091
50sleep (GO:0030431)2.92663848
51adenosine metabolic process (GO:0046085)2.92103346
52positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.91825156
53neuronal action potential propagation (GO:0019227)2.91406263
54protein neddylation (GO:0045116)2.91172216
55negative regulation of telomere maintenance (GO:0032205)2.89035532
56synaptic vesicle exocytosis (GO:0016079)2.88514129
57mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.88449273
58axonemal dynein complex assembly (GO:0070286)2.85157286
59negative regulation of mast cell activation (GO:0033004)2.84784986
60regulation of short-term neuronal synaptic plasticity (GO:0048172)2.84315273
61positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.83025595
62L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.82437887
63locomotory exploration behavior (GO:0035641)2.81253668
64regulation of synaptic vesicle exocytosis (GO:2000300)2.78558194
65detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.77047527
66respiratory electron transport chain (GO:0022904)2.74891456
67electron transport chain (GO:0022900)2.74503979
68cerebral cortex neuron differentiation (GO:0021895)2.74170839
69vocalization behavior (GO:0071625)2.72504095
70autophagic vacuole fusion (GO:0000046)2.71239347
71membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.70942536
72negative regulation of neurotransmitter secretion (GO:0046929)2.70157641
73cellular potassium ion homeostasis (GO:0030007)2.69975337
74establishment of protein localization to mitochondrial membrane (GO:0090151)2.69835480
75neural tube formation (GO:0001841)2.68760615
76neuron remodeling (GO:0016322)2.67349831
77protein localization to cilium (GO:0061512)2.65743275
78positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.65657182
79positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.65571359
80peptidyl-tyrosine autophosphorylation (GO:0038083)2.62277649
81regulation of cell communication by electrical coupling (GO:0010649)2.61082295
82glutamate secretion (GO:0014047)2.59078795
83creatine metabolic process (GO:0006600)2.57352174
84positive regulation of amino acid transport (GO:0051957)2.57331948
85amino acid salvage (GO:0043102)2.56073019
86L-methionine salvage (GO:0071267)2.56073019
87L-methionine biosynthetic process (GO:0071265)2.56073019
88kynurenine metabolic process (GO:0070189)2.55281805
89purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.55026215
90cilium movement (GO:0003341)2.54886666
91regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.54629905
92synaptic vesicle docking involved in exocytosis (GO:0016081)2.51468282
93potassium ion import (GO:0010107)2.50618940
94positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.48657929
95indole-containing compound catabolic process (GO:0042436)2.48154193
96indolalkylamine catabolic process (GO:0046218)2.48154193
97tryptophan catabolic process (GO:0006569)2.48154193
98regulation of skeletal muscle contraction (GO:0014819)2.48066480
99chaperone-mediated protein transport (GO:0072321)2.47647587
100regulation of voltage-gated calcium channel activity (GO:1901385)2.46789754
101centriole replication (GO:0007099)2.46739288
102negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.45518262
103neurotransmitter catabolic process (GO:0042135)2.45498533
104platelet dense granule organization (GO:0060155)2.45384740
105protein deneddylation (GO:0000338)2.45164773
106axon ensheathment in central nervous system (GO:0032291)2.43924210
107central nervous system myelination (GO:0022010)2.43924210
108cerebellar granule cell differentiation (GO:0021707)2.43599964
109regulation of synapse structural plasticity (GO:0051823)2.43146444
110cilium morphogenesis (GO:0060271)2.43007185
111GPI anchor metabolic process (GO:0006505)2.42653221
112protein K6-linked ubiquitination (GO:0085020)2.42038404
113regulation of synaptic vesicle transport (GO:1902803)2.41751765
114regulation of memory T cell differentiation (GO:0043380)2.41270480
115neuronal action potential (GO:0019228)2.40398568
116negative regulation of appetite (GO:0032099)2.38147631
117negative regulation of response to food (GO:0032096)2.38147631
118positive regulation of mRNA 3-end processing (GO:0031442)2.37678094
119response to gravity (GO:0009629)2.37587562
120pyrimidine ribonucleoside catabolic process (GO:0046133)2.34194168
121detection of mechanical stimulus involved in sensory perception (GO:0050974)2.34054555
122proton transport (GO:0015992)2.33910795
123fatty acid elongation (GO:0030497)2.33821652
124hydrogen ion transmembrane transport (GO:1902600)2.33047796
125proline transport (GO:0015824)2.32723209
126long term synaptic depression (GO:0060292)2.32561458
127sarcoplasmic reticulum calcium ion transport (GO:0070296)2.32504557
128negative regulation of synaptic transmission, GABAergic (GO:0032229)2.31654066
129cullin deneddylation (GO:0010388)2.30924028
130hydrogen transport (GO:0006818)2.29927805
131mating behavior (GO:0007617)2.29671084
132protein localization to synapse (GO:0035418)2.28524932
133gamma-aminobutyric acid signaling pathway (GO:0007214)2.27944697
134protein targeting to Golgi (GO:0000042)2.27687761
135regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.27505338
136potassium ion homeostasis (GO:0055075)2.26930725
137regulation of glutamate receptor signaling pathway (GO:1900449)2.26284501
138ionotropic glutamate receptor signaling pathway (GO:0035235)2.23138339
139positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.22016440
140protein localization to endosome (GO:0036010)2.20236213
141glycine transport (GO:0015816)2.19921110
142positive regulation of potassium ion transport (GO:0043268)2.16724309
143vesicle transport along microtubule (GO:0047496)2.16568710
144regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.15275007
145regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.15113542
146nerve growth factor signaling pathway (GO:0038180)2.12807248
147positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.10382203
148neuron-neuron synaptic transmission (GO:0007270)2.09370335
149neurotransmitter secretion (GO:0007269)2.09179896
150axon ensheathment (GO:0008366)2.09159096
151ensheathment of neurons (GO:0007272)2.09159096
152regulation of calcium ion transmembrane transport (GO:1903169)2.08429127
153regulation of calcium ion transmembrane transporter activity (GO:1901019)2.08429127
154neurotransmitter-gated ion channel clustering (GO:0072578)2.08076974
155regulation of membrane repolarization (GO:0060306)2.06794414
156negative regulation of potassium ion transmembrane transport (GO:1901380)2.06705552
157glutamate receptor signaling pathway (GO:0007215)2.06688667
158myelination (GO:0042552)2.06022354
159positive regulation of potassium ion transmembrane transport (GO:1901381)2.04644218
160regulation of excitatory postsynaptic membrane potential (GO:0060079)2.03453663
161establishment of protein localization to Golgi (GO:0072600)2.01397725
162activation of protein kinase A activity (GO:0034199)2.01152192
163negative regulation of protein localization to cell surface (GO:2000009)2.00955755
164photoreceptor cell differentiation (GO:0046530)2.00500286
165eye photoreceptor cell differentiation (GO:0001754)2.00500286
166regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.00174770
167regulation of dendritic spine morphogenesis (GO:0061001)2.00105451
168synaptic transmission, glutamatergic (GO:0035249)1.99319803
169retrograde transport, vesicle recycling within Golgi (GO:0000301)1.99296076
170L-amino acid import (GO:0043092)1.98521147
171regulation of neuronal synaptic plasticity (GO:0048168)1.98080556
172detection of calcium ion (GO:0005513)1.97836001
173long-term memory (GO:0007616)1.97782104
174response to pheromone (GO:0019236)1.97058426
175aminoglycoside antibiotic metabolic process (GO:0030647)1.96945121
176layer formation in cerebral cortex (GO:0021819)1.96943719
177plasma membrane repair (GO:0001778)1.96692364
178positive regulation of sodium ion transmembrane transport (GO:1902307)1.96566025
179negative regulation of synaptic transmission, glutamatergic (GO:0051967)1.96023812
180positive regulation of membrane potential (GO:0045838)1.95769445
181regulation of long-term neuronal synaptic plasticity (GO:0048169)1.95212804
182calcium-mediated signaling using intracellular calcium source (GO:0035584)1.95135927
183detection of temperature stimulus (GO:0016048)1.93719766
184membrane depolarization during action potential (GO:0086010)1.93431130
185response to dietary excess (GO:0002021)1.93294719
186transmission of nerve impulse (GO:0019226)1.93267319
187neuron cell-cell adhesion (GO:0007158)1.93074968
188sodium ion export (GO:0071436)1.92796575
189negative regulation of neurotransmitter transport (GO:0051589)1.92776884
190import into cell (GO:0098657)1.92631727
191regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)1.92144547
192regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)1.92046427
193neurotransmitter transport (GO:0006836)1.91850899
194regulation of dendritic spine development (GO:0060998)1.91786001

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human3.35632398
2ZNF274_21170338_ChIP-Seq_K562_Hela3.02338531
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.81769419
4IGF1R_20145208_ChIP-Seq_DFB_Human2.56303760
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.54926078
6EZH2_22144423_ChIP-Seq_EOC_Human2.54067892
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.52175672
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.51414759
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.42975875
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.41035819
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.30164800
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.30164800
13* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.26498788
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.25859287
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.21630983
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.17042740
17FUS_26573619_Chip-Seq_HEK293_Human2.15286772
18* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.14121043
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.13352582
20GBX2_23144817_ChIP-Seq_PC3_Human2.13148122
21MTF2_20144788_ChIP-Seq_MESCs_Mouse2.12239050
22EWS_26573619_Chip-Seq_HEK293_Human2.12005425
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.05782361
24ER_23166858_ChIP-Seq_MCF-7_Human2.04093378
25JARID2_20075857_ChIP-Seq_MESCs_Mouse2.03722947
26SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.02332370
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.99986840
28EST1_17652178_ChIP-ChIP_JURKAT_Human1.95834104
29ELF1_17652178_ChIP-ChIP_JURKAT_Human1.93763151
30BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.90648480
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.87465483
32SUZ12_27294783_Chip-Seq_ESCs_Mouse1.81829550
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.81401174
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.79641243
35DROSHA_22980978_ChIP-Seq_HELA_Human1.78931856
36EZH2_27304074_Chip-Seq_ESCs_Mouse1.78665807
37* VDR_23849224_ChIP-Seq_CD4+_Human1.74252334
38KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.70462142
39FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.69969608
40PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.68526122
41NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.67908720
42* RNF2_27304074_Chip-Seq_ESCs_Mouse1.64065038
43TP53_22573176_ChIP-Seq_HFKS_Human1.58623460
44IKZF1_21737484_ChIP-ChIP_HCT116_Human1.56968457
45AR_21572438_ChIP-Seq_LNCaP_Human1.54186491
46CDX2_19796622_ChIP-Seq_MESCs_Mouse1.50161888
47RARB_27405468_Chip-Seq_BRAIN_Mouse1.48447770
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.48242196
49ELK1_19687146_ChIP-ChIP_HELA_Human1.48212004
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47362428
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.43662284
52ESR1_20079471_ChIP-ChIP_T-47D_Human1.42556476
53* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.39782818
54EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.38727741
55LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.37331559
56REST_21632747_ChIP-Seq_MESCs_Mouse1.34164191
57ZNF217_24962896_ChIP-Seq_MCF-7_Human1.32648263
58PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.29055736
59* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.28075651
60IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.26992666
61TAF15_26573619_Chip-Seq_HEK293_Human1.26961028
62* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24505826
63* CBP_20019798_ChIP-Seq_JUKART_Human1.24389127
64* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24389127
65CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.23588174
66CBX2_27304074_Chip-Seq_ESCs_Mouse1.23584665
67IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.23004834
68WT1_25993318_ChIP-Seq_PODOCYTE_Human1.22318797
69SRF_21415370_ChIP-Seq_HL-1_Mouse1.21802752
70FOXA1_27270436_Chip-Seq_PROSTATE_Human1.21671339
71FOXA1_25329375_ChIP-Seq_VCAP_Human1.21671339
72CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.21264235
73THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20822794
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20770438
75* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19678489
76ESR2_21235772_ChIP-Seq_MCF-7_Human1.19314706
77EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.18984549
78FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17655441
79RXR_22108803_ChIP-Seq_LS180_Human1.17435708
80PIAS1_25552417_ChIP-Seq_VCAP_Human1.17269730
81MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.17141238
82NANOG_19829295_ChIP-Seq_ESCs_Human1.16910766
83SOX2_19829295_ChIP-Seq_ESCs_Human1.16910766
84EP300_21415370_ChIP-Seq_HL-1_Mouse1.16787668
85* GATA3_26560356_Chip-Seq_TH2_Human1.16446004
86VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.16141701
87NOTCH1_21737748_ChIP-Seq_TLL_Human1.15879057
88SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15516360
89REST_18959480_ChIP-ChIP_MESCs_Mouse1.15497359
90ERG_21242973_ChIP-ChIP_JURKAT_Human1.15046589
91GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13566883
92SMAD_19615063_ChIP-ChIP_OVARY_Human1.13015254
93FLI1_21867929_ChIP-Seq_TH2_Mouse1.12892647
94SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12731187
95SMAD4_21799915_ChIP-Seq_A2780_Human1.11656308
96GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.11217950
97TCF4_22108803_ChIP-Seq_LS180_Human1.10877014
98TRIM28_21343339_ChIP-Seq_HEK293_Human1.10717995
99EZH2_27294783_Chip-Seq_NPCs_Mouse1.10361576
100AR_20517297_ChIP-Seq_VCAP_Human1.10072810
101AHR_22903824_ChIP-Seq_MCF-7_Human1.10007936
102PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09994347
103BCAT_22108803_ChIP-Seq_LS180_Human1.09343628
104WT1_19549856_ChIP-ChIP_CCG9911_Human1.09138222
105NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09114769
106WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.08093605
107STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.08093443
108NFE2_27457419_Chip-Seq_LIVER_Mouse1.06884128
109NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06821114
110NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06821114
111PRDM14_20953172_ChIP-Seq_ESCs_Human1.05552863
112P53_22387025_ChIP-Seq_ESCs_Mouse1.05527793
113SMAD3_21741376_ChIP-Seq_HESCs_Human1.05255801
114P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05107728
115MYC_18940864_ChIP-ChIP_HL60_Human1.04826140
116ARNT_22903824_ChIP-Seq_MCF-7_Human1.04226701
117* RNF2_27304074_Chip-Seq_NSC_Mouse1.02981144
118TCF4_23295773_ChIP-Seq_U87_Human1.02004054
119SOX2_21211035_ChIP-Seq_LN229_Gbm1.01285982
120KDM2B_26808549_Chip-Seq_K562_Human1.00803190
121* GATA2_21666600_ChIP-Seq_HMVEC_Human1.00300048
122EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00250470
123CRX_20693478_ChIP-Seq_RETINA_Mouse0.99999997
124BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99540242
125IRF1_19129219_ChIP-ChIP_H3396_Human0.98870058
126TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98721156
127GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98669599
128CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.97882383
129SMAD4_21741376_ChIP-Seq_HESCs_Human0.97798573
130FOXP3_21729870_ChIP-Seq_TREG_Human0.97687630
131* IRF8_21731497_ChIP-ChIP_J774_Mouse0.97667036
132* DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96953218
133SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96853261
134* SALL4_22934838_ChIP-ChIP_CD34+_Human0.96665842
135PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96602898
136NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.96385757
137* RING1B_27294783_Chip-Seq_ESCs_Mouse0.96033822
138PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95665173
139OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95528190
140GATA3_21878914_ChIP-Seq_MCF-7_Human0.94163075
141RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.92993421
142EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92699942
143AR_25329375_ChIP-Seq_VCAP_Human0.92616959
144CTBP1_25329375_ChIP-Seq_LNCAP_Human0.92335446
145RING1B_27294783_Chip-Seq_NPCs_Mouse0.90651872
146SMAD3_21741376_ChIP-Seq_EPCs_Human0.90478858
147P300_19829295_ChIP-Seq_ESCs_Human0.89633829
148ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89581491
149STAT3_23295773_ChIP-Seq_U87_Human0.88986997
150TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.88892656
151TP53_18474530_ChIP-ChIP_U2OS_Human0.87380458
152TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87060845
153ZFP57_27257070_Chip-Seq_ESCs_Mouse0.86163663
154AR_19668381_ChIP-Seq_PC3_Human0.85490596
155SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84794892
156BMI1_23680149_ChIP-Seq_NPCS_Mouse0.84038156
157* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.83503638
158MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.83330182
159NR3C1_21868756_ChIP-Seq_MCF10A_Human0.82423861
160NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.82259293
161KDM2B_26808549_Chip-Seq_SUP-B15_Human0.81808685
162CTBP2_25329375_ChIP-Seq_LNCAP_Human0.81607064
163* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.81179809
164LXR_22158963_ChIP-Seq_LIVER_Mouse0.80411093
165STAT6_21828071_ChIP-Seq_BEAS2B_Human0.80242946
166AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.79369225
167PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.79087339
168FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.78003058
169FOXO3_23340844_ChIP-Seq_DLD1_Human0.77879791
170EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.77598440
171TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76634961
172TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.75719583

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.71907702
2MP0003136_yellow_coat_color3.00492838
3MP0002653_abnormal_ependyma_morphology2.99695200
4MP0004270_analgesia2.87108837
5MP0003880_abnormal_central_pattern2.42149230
6MP0003635_abnormal_synaptic_transmissio2.39386485
7MP0002064_seizures2.22653292
8MP0002837_dystrophic_cardiac_calcinosis2.19572538
9MP0000920_abnormal_myelination2.12179821
10MP0009046_muscle_twitch2.11707680
11MP0008877_abnormal_DNA_methylation2.11401864
12MP0002822_catalepsy2.10369253
13MP0000751_myopathy2.09083476
14MP0001486_abnormal_startle_reflex2.02587202
15MP0005084_abnormal_gallbladder_morpholo2.02274442
16MP0009745_abnormal_behavioral_response2.02150948
17MP0003724_increased_susceptibility_to1.98357968
18MP0003329_amyloid_beta_deposits1.92627749
19MP0002272_abnormal_nervous_system1.92442777
20MP0004145_abnormal_muscle_electrophysio1.90157482
21MP0002734_abnormal_mechanical_nocicepti1.81172209
22MP0002876_abnormal_thyroid_physiology1.78694348
23MP0000749_muscle_degeneration1.77469435
24MP0004858_abnormal_nervous_system1.76545891
25MP0002102_abnormal_ear_morphology1.74392126
26MP0005551_abnormal_eye_electrophysiolog1.71177387
27MP0005645_abnormal_hypothalamus_physiol1.70579345
28MP0004036_abnormal_muscle_relaxation1.69256355
29MP0002063_abnormal_learning/memory/cond1.68463327
30MP0003690_abnormal_glial_cell1.66735655
31MP0001501_abnormal_sleep_pattern1.60336170
32MP0001986_abnormal_taste_sensitivity1.60166232
33MP0002572_abnormal_emotion/affect_behav1.59305188
34MP0008004_abnormal_stomach_pH1.58998172
35MP0005646_abnormal_pituitary_gland1.58033428
36MP0000372_irregular_coat_pigmentation1.56838734
37MP0003195_calcinosis1.56150459
38MP0008872_abnormal_physiological_respon1.54749067
39MP0002090_abnormal_vision1.53778316
40MP0002234_abnormal_pharynx_morphology1.47591042
41MP0001968_abnormal_touch/_nociception1.45463596
42MP0001440_abnormal_grooming_behavior1.45248636
43MP0002638_abnormal_pupillary_reflex1.44247215
44MP0003787_abnormal_imprinting1.44177786
45MP0008569_lethality_at_weaning1.43592947
46MP0008058_abnormal_DNA_repair1.42367205
47MP0002735_abnormal_chemical_nociception1.42365122
48MP0002254_reproductive_system_inflammat1.40511746
49MP0002909_abnormal_adrenal_gland1.40027486
50MP0003950_abnormal_plasma_membrane1.39456842
51MP0005671_abnormal_response_to1.39042519
52MP0003806_abnormal_nucleotide_metabolis1.38530546
53MP0003011_delayed_dark_adaptation1.38258988
54MP0006036_abnormal_mitochondrial_physio1.37492223
55MP0000569_abnormal_digit_pigmentation1.36950889
56MP0004085_abnormal_heartbeat1.36160236
57MP0001970_abnormal_pain_threshold1.36037726
58MP0005620_abnormal_muscle_contractility1.31324716
59MP0004043_abnormal_pH_regulation1.30499742
60MP0003252_abnormal_bile_duct1.29570597
61MP0003075_altered_response_to1.27977585
62MP0004130_abnormal_muscle_cell1.27879321
63MP0000747_muscle_weakness1.27217693
64MP0002928_abnormal_bile_duct1.24939360
65MP0003633_abnormal_nervous_system1.23341326
66MP0002067_abnormal_sensory_capabilities1.21910733
67MP0004215_abnormal_myocardial_fiber1.21415477
68MP0009780_abnormal_chondrocyte_physiolo1.21343703
69MP0002733_abnormal_thermal_nociception1.21198637
70MP0004885_abnormal_endolymph1.21139168
71MP0005423_abnormal_somatic_nervous1.18867901
72MP0002332_abnormal_exercise_endurance1.18291504
73MP0005075_abnormal_melanosome_morpholog1.18148705
74MP0003866_abnormal_defecation1.17870101
75MP0002938_white_spotting1.17797757
76MP0008874_decreased_physiological_sensi1.17541312
77MP0000604_amyloidosis1.17344449
78MP0001835_abnormal_antigen_presentation1.14013650
79MP0001529_abnormal_vocalization1.13832501
80MP0001346_abnormal_lacrimal_gland1.13025612
81MP0004510_myositis1.12823972
82MP0004087_abnormal_muscle_fiber1.12228618
83MP0005253_abnormal_eye_physiology1.11921758
84MP0004185_abnormal_adipocyte_glucose1.10715802
85MP0003045_fibrosis1.10321131
86MP0003634_abnormal_glial_cell1.09574394
87MP0003879_abnormal_hair_cell1.09121734
88MP0005083_abnormal_biliary_tract1.08325100
89MP0000631_abnormal_neuroendocrine_gland1.08146102
90MP0008961_abnormal_basal_metabolism1.08103979
91MP0006072_abnormal_retinal_apoptosis1.07146614
92MP0001485_abnormal_pinna_reflex1.06619133
93MP0000759_abnormal_skeletal_muscle1.06567803
94MP0002229_neurodegeneration1.06524939
95MP0005174_abnormal_tail_pigmentation1.05674138
96MP0003137_abnormal_impulse_conducting1.05611730
97MP0004484_altered_response_of1.05149565
98MP0005330_cardiomyopathy1.04807718
99MP0004084_abnormal_cardiac_muscle1.03459733
100MP0000750_abnormal_muscle_regeneration1.02975446
101MP0002184_abnormal_innervation1.01087721
102MP0002972_abnormal_cardiac_muscle1.00871793
103MP0001664_abnormal_digestion0.99314678
104MP0002736_abnormal_nociception_after0.99291656
105MP0010368_abnormal_lymphatic_system0.96615429
106MP0008875_abnormal_xenobiotic_pharmacok0.96575969
107MP0004742_abnormal_vestibular_system0.96551915
108MP0006292_abnormal_olfactory_placode0.96024335
109MP0002277_abnormal_respiratory_mucosa0.95601591
110MP0010386_abnormal_urinary_bladder0.93703020
111MP0005386_behavior/neurological_phenoty0.93488085
112MP0004924_abnormal_behavior0.93488085
113MP0002066_abnormal_motor_capabilities/c0.93093150
114MP0002106_abnormal_muscle_physiology0.92263791
115MP0003183_abnormal_peptide_metabolism0.92221898
116MP0005623_abnormal_meninges_morphology0.92074860
117MP0001299_abnormal_eye_distance/0.90147837
118MP0005367_renal/urinary_system_phenotyp0.89800861
119MP0000516_abnormal_urinary_system0.89800861
120MP0003646_muscle_fatigue0.89704946
121MP0001851_eye_inflammation0.89310753
122MP0002282_abnormal_trachea_morphology0.89148139
123MP0000230_abnormal_systemic_arterial0.88921619
124MP0001919_abnormal_reproductive_system0.88882855
125MP0004142_abnormal_muscle_tone0.88599957
126MP0002882_abnormal_neuron_morphology0.88460338
127MP0002166_altered_tumor_susceptibility0.87867562
128MP0003631_nervous_system_phenotype0.87430774
129MP0001984_abnormal_olfaction0.86663687
130MP0000955_abnormal_spinal_cord0.85862522
131MP0002095_abnormal_skin_pigmentation0.85202081
132MP0005535_abnormal_body_temperature0.84488376
133MP0005365_abnormal_bile_salt0.83704026
134MP0005167_abnormal_blood-brain_barrier0.83651524
135MP0005369_muscle_phenotype0.83556146
136MP0006276_abnormal_autonomic_nervous0.83357629
137MP0005171_absent_coat_pigmentation0.83290502
138MP0001348_abnormal_lacrimal_gland0.82305580
139MP0005389_reproductive_system_phenotype0.81783822
140MP0005085_abnormal_gallbladder_physiolo0.81431863
141MP0000013_abnormal_adipose_tissue0.80307785
142MP0005332_abnormal_amino_acid0.79049809
143MP0001905_abnormal_dopamine_level0.78272410
144MP0003283_abnormal_digestive_organ0.78215425
145MP0001800_abnormal_humoral_immune0.77880480
146MP0001502_abnormal_circadian_rhythm0.77095164
147MP0008775_abnormal_heart_ventricle0.76488855
148MP0004811_abnormal_neuron_physiology0.75686295
149MP0002557_abnormal_social/conspecific_i0.75517954
150MP0004147_increased_porphyrin_level0.75361719
151MP0005257_abnormal_intraocular_pressure0.75065291
152MP0002148_abnormal_hypersensitivity_rea0.74859007
153MP0001765_abnormal_ion_homeostasis0.74296671
154MP0001963_abnormal_hearing_physiology0.73262361
155MP0000427_abnormal_hair_cycle0.73150212
156MP0006054_spinal_hemorrhage0.72827688
157MP0002160_abnormal_reproductive_system0.71367997
158MP0001756_abnormal_urination0.71089615
159MP0000026_abnormal_inner_ear0.69212980

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.03280011
2Pancreatic cysts (HP:0001737)4.02012223
3Exercise-induced myalgia (HP:0003738)4.00720856
4True hermaphroditism (HP:0010459)3.65132938
5Myokymia (HP:0002411)3.61734118
6Pancreatic fibrosis (HP:0100732)3.50180191
7Neurofibrillary tangles (HP:0002185)3.42938947
8Renal cortical cysts (HP:0000803)3.42459437
9Atonic seizures (HP:0010819)3.30807427
10Muscle hypertrophy of the lower extremities (HP:0008968)3.24034968
11Difficulty running (HP:0009046)3.16956665
12Tubulointerstitial nephritis (HP:0001970)3.15475031
13Mitochondrial inheritance (HP:0001427)3.13571230
14Large for gestational age (HP:0001520)3.12999097
15Abnormality of the renal cortex (HP:0011035)3.12998034
16Absent/shortened dynein arms (HP:0200106)3.12953105
17Dynein arm defect of respiratory motile cilia (HP:0012255)3.12953105
18Hyporeflexia of lower limbs (HP:0002600)3.12009753
19Exercise-induced muscle cramps (HP:0003710)3.11275842
20Neuroendocrine neoplasm (HP:0100634)3.08104909
21Calf muscle hypertrophy (HP:0008981)3.02768877
22Supranuclear gaze palsy (HP:0000605)3.00479784
23Focal seizures (HP:0007359)2.98582418
24Medial flaring of the eyebrow (HP:0010747)2.97691238
25Nephronophthisis (HP:0000090)2.95860758
26Abnormality of midbrain morphology (HP:0002418)2.91514184
27Molar tooth sign on MRI (HP:0002419)2.91514184
28Action tremor (HP:0002345)2.91408856
29Epileptic encephalopathy (HP:0200134)2.87516709
30Febrile seizures (HP:0002373)2.87509338
31EMG: myopathic abnormalities (HP:0003458)2.86174943
32Increased hepatocellular lipid droplets (HP:0006565)2.85819859
33Progressive microcephaly (HP:0000253)2.84849888
34Abnormal respiratory motile cilium morphology (HP:0005938)2.82005332
35Abnormal respiratory epithelium morphology (HP:0012253)2.82005332
36Muscle fiber inclusion bodies (HP:0100299)2.81011612
37Lipid accumulation in hepatocytes (HP:0006561)2.79206316
38Hepatocellular necrosis (HP:0001404)2.77781646
39Hepatic necrosis (HP:0002605)2.76761445
40Muscle fiber splitting (HP:0003555)2.76532336
41Hemiparesis (HP:0001269)2.75120464
42Increased CSF lactate (HP:0002490)2.73627557
43Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.68462406
44Cerebral inclusion bodies (HP:0100314)2.67343733
45Renal Fanconi syndrome (HP:0001994)2.66125549
46Parakeratosis (HP:0001036)2.65005957
47Methylmalonic acidemia (HP:0002912)2.63815193
48Onion bulb formation (HP:0003383)2.63644707
49Nemaline bodies (HP:0003798)2.62948661
50Dialeptic seizures (HP:0011146)2.62579603
51Increased variability in muscle fiber diameter (HP:0003557)2.61795873
52Absence seizures (HP:0002121)2.61571714
53Congenital, generalized hypertrichosis (HP:0004540)2.61366157
54Hyperventilation (HP:0002883)2.60461678
55Generalized tonic-clonic seizures (HP:0002069)2.59874581
56Central scotoma (HP:0000603)2.59042766
57Severe combined immunodeficiency (HP:0004430)2.55932651
58Acute necrotizing encephalopathy (HP:0006965)2.53014258
59Sudden death (HP:0001699)2.51037494
60Thyroiditis (HP:0100646)2.50168011
61Abnormality of the calf musculature (HP:0001430)2.49638603
62Myotonia (HP:0002486)2.49441968
63Visual hallucinations (HP:0002367)2.48613735
64Round ear (HP:0100830)2.42824379
65Abnormality of the renal medulla (HP:0100957)2.42726505
66Progressive macrocephaly (HP:0004481)2.42104864
673-Methylglutaconic aciduria (HP:0003535)2.41654481
68Dysmetria (HP:0001310)2.41353922
69Muscle stiffness (HP:0003552)2.38394351
70Atrial fibrillation (HP:0005110)2.35288759
71Hypothermia (HP:0002045)2.35284158
72Intention tremor (HP:0002080)2.34666661
73Increased connective tissue (HP:0009025)2.33265050
74Congenital stationary night blindness (HP:0007642)2.29045577
75Elevated erythrocyte sedimentation rate (HP:0003565)2.28124446
76Abnormality of skeletal muscle fiber size (HP:0012084)2.27876993
77Abnormal mitochondria in muscle tissue (HP:0008316)2.27694580
78Type 1 muscle fiber predominance (HP:0003803)2.27365096
79Abnormality of the corticospinal tract (HP:0002492)2.26193200
80Hyperkalemia (HP:0002153)2.25842055
81Gait imbalance (HP:0002141)2.24125820
82Primary atrial arrhythmia (HP:0001692)2.24101636
83Cystic liver disease (HP:0006706)2.22310883
84Sclerocornea (HP:0000647)2.19960359
85Ventricular fibrillation (HP:0001663)2.18428268
86Optic disc pallor (HP:0000543)2.17799136
87Sensory axonal neuropathy (HP:0003390)2.17458694
88Dysdiadochokinesis (HP:0002075)2.17066924
89Increased intramyocellular lipid droplets (HP:0012240)2.16928850
90Inability to walk (HP:0002540)2.16623424
91Achilles tendon contracture (HP:0001771)2.16514434
92Rapidly progressive (HP:0003678)2.14180480
93Attenuation of retinal blood vessels (HP:0007843)2.13934295
94Methylmalonic aciduria (HP:0012120)2.13737426
95Progressive cerebellar ataxia (HP:0002073)2.13168813
96Congenital primary aphakia (HP:0007707)2.12197185
97Syncope (HP:0001279)2.11688704
98Acute encephalopathy (HP:0006846)2.11570764
99Exertional dyspnea (HP:0002875)2.11075072
100Increased serum lactate (HP:0002151)2.11023597
101Termporal pattern (HP:0011008)2.10445344
102Insidious onset (HP:0003587)2.10445344
103Abnormality of the Achilles tendon (HP:0005109)2.10345190
104Abnormality of macular pigmentation (HP:0008002)2.09903875
105Scotoma (HP:0000575)2.09688351
106Abnormal number of erythroid precursors (HP:0012131)2.08815705
107Concave nail (HP:0001598)2.07219107
108Cerebral hemorrhage (HP:0001342)2.06683583
109Decreased electroretinogram (ERG) amplitude (HP:0000654)2.06424639
110Broad-based gait (HP:0002136)2.05311955
111Rib fusion (HP:0000902)2.03962388
112Supraventricular tachycardia (HP:0004755)2.02901461
113Lactic acidosis (HP:0003128)2.02350785
114Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.01731532
115Ankle clonus (HP:0011448)2.00771369
116Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.00468339
117Ketoacidosis (HP:0001993)1.99034626
118Congenital hepatic fibrosis (HP:0002612)1.98786232
119Prolonged QT interval (HP:0001657)1.98723630
120Furrowed tongue (HP:0000221)1.98370032
121Supraventricular arrhythmia (HP:0005115)1.97513388
122Bile duct proliferation (HP:0001408)1.97311707
123Abnormal biliary tract physiology (HP:0012439)1.97311707
124Steppage gait (HP:0003376)1.97098108
125Ketosis (HP:0001946)1.96901271
126Pachygyria (HP:0001302)1.96814670
127Postaxial foot polydactyly (HP:0001830)1.96575401
128Stomatitis (HP:0010280)1.95723743
129Absent speech (HP:0001344)1.95663622
130Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.95026396
131Abnormality of alanine metabolism (HP:0010916)1.95026396
132Hyperalaninemia (HP:0003348)1.95026396
133Distal arthrogryposis (HP:0005684)1.92733191
134Constricted visual fields (HP:0001133)1.92295261
135Scapular winging (HP:0003691)1.91126465
136Pheochromocytoma (HP:0002666)1.91113790
137Abnormality of renal resorption (HP:0011038)1.90991021
138Nephrogenic diabetes insipidus (HP:0009806)1.90769982
139Anencephaly (HP:0002323)1.90317583
140Progressive inability to walk (HP:0002505)1.89809561
141Mitral stenosis (HP:0001718)1.89199278
142Myoglobinuria (HP:0002913)1.87759229
143Spastic gait (HP:0002064)1.87510185
144Spastic tetraparesis (HP:0001285)1.86186743
145Increased muscle lipid content (HP:0009058)1.85613101
146Anxiety (HP:0000739)1.85498467
147Ventricular tachycardia (HP:0004756)1.84761221
148Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.84696831
149Clumsiness (HP:0002312)1.84372933
150IgG deficiency (HP:0004315)1.83883067
151Type II lissencephaly (HP:0007260)1.83873380
152Aplasia/Hypoplasia of the tongue (HP:0010295)1.83734261
153Facial diplegia (HP:0001349)1.83484279
154Postural instability (HP:0002172)1.81874061
155CNS demyelination (HP:0007305)1.81391984
156Tinnitus (HP:0000360)1.79422075
157Amblyopia (HP:0000646)1.79365055
158Abnormal ciliary motility (HP:0012262)1.78795108
159Foot dorsiflexor weakness (HP:0009027)1.78659326
160Abnormal respiratory motile cilium physiology (HP:0012261)1.78359936
161Abnormality of the vocal cords (HP:0008777)1.78222972
162Male pseudohermaphroditism (HP:0000037)1.77836372
163Depression (HP:0000716)1.77750464
164Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.77470710
165Degeneration of the lateral corticospinal tracts (HP:0002314)1.77470710
166Amyloidosis (HP:0011034)1.76854890
167Resting tremor (HP:0002322)1.76651267
168Abolished electroretinogram (ERG) (HP:0000550)1.76384500
169Neuronal loss in central nervous system (HP:0002529)1.75871823
170Status epilepticus (HP:0002133)1.73925085
171Gout (HP:0001997)1.73499394
172Generalized myoclonic seizures (HP:0002123)1.72233288
173Scanning speech (HP:0002168)1.70616808
174Deep venous thrombosis (HP:0002625)1.69852506
175Postural tremor (HP:0002174)1.67883675
176Axonal loss (HP:0003447)1.66490908
177Frequent falls (HP:0002359)1.66012921
178Gaze-evoked nystagmus (HP:0000640)1.65478356
179Cholelithiasis (HP:0001081)1.65428446
180Bradycardia (HP:0001662)1.64845101
181Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.64475554
182Ventricular arrhythmia (HP:0004308)1.63816363
183Abnormal gallbladder morphology (HP:0012437)1.63382351
184Bundle branch block (HP:0011710)1.63194449
185Ulnar claw (HP:0001178)1.62931937
186Abnormal EKG (HP:0003115)1.61932681
187Hammertoe (HP:0001765)1.61914761

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.48079733
2BCKDK3.11342480
3BMPR1B3.02169464
4GRK52.59200106
5CCNB12.51069381
6MAP4K22.45605941
7MAPK132.13881383
8EPHA42.12296917
9WNK12.10113033
10VRK22.07083341
11PNCK2.03425462
12TLK12.01984672
13EPHB12.01482082
14MAP2K42.01218232
15STK392.00212138
16VRK11.92422330
17ERN11.90480922
18NTRK31.90068707
19MAPK151.88692949
20SIK21.84009071
21NTRK11.82629790
22PHKG11.79864359
23PHKG21.79864359
24PAK61.78955487
25OXSR11.78649662
26EPHA31.73589515
27GRK71.72009495
28SIK31.71752433
29TXK1.64503442
30KSR21.61248394
31SIK11.57807501
32MAP3K91.52724440
33MAP3K131.49291248
34NUAK11.47813644
35ZAK1.45201164
36TESK21.42436282
37EIF2AK31.39950765
38MARK21.37331057
39CDK81.30699436
40MINK11.28743892
41MAPKAPK31.28299181
42PAK31.28176230
43DMPK1.28103875
44STK161.27364418
45KIT1.27294836
46DAPK21.26304633
47OBSCN1.24026263
48MAP3K71.23008885
49RIPK41.22618262
50CDK191.21600090
51TGFBR21.20530069
52TTN1.20362788
53GRK11.17360867
54MAPK121.16800225
55ERBB31.14988436
56PKN11.13456455
57PRPF4B1.09776379
58MST41.07392953
59WNK31.06756279
60FES1.04290210
61PTK2B1.01557693
62MAP3K41.00736132
63CAMKK10.97454465
64BMPR20.97381321
65RET0.96517989
66MAPK70.95266384
67MAP3K20.95223987
68PRKCG0.95080600
69TEC0.93722252
70CDK50.93436162
71WEE10.93215252
72PDPK10.90996060
73WNK40.90851425
74PRKCH0.90792212
75TYRO30.90270257
76CAMK40.90163436
77PASK0.89805366
78TAOK10.88165348
79TRIB30.87347742
80ADRBK20.86732395
81MAPKAPK50.86482312
82SYK0.86424932
83PIK3CA0.86080701
84PRKD10.85259683
85EIF2AK10.83340708
86INSRR0.83130654
87SGK4940.79811478
88SGK2230.79811478
89CAMK1G0.79551211
90TGFBR10.79374784
91CAMK10.76871148
92MAP3K10.76238725
93CAMK2A0.74965851
94PIK3CG0.74156769
95DYRK20.74083020
96ARAF0.73196395
97RPS6KA50.71796799
98FER0.71595496
99FGR0.71134598
100CAMK2D0.68947545
101PDK10.68817708
102TNIK0.68790707
103CAMK2G0.67532436
104STK380.67059841
105ROCK20.66318620
106GRK60.64346395
107ITK0.63630061
108HIPK20.63232448
109MARK10.62436614
110FYN0.62412668
111MOS0.61981409
112CAMK2B0.61901248
113TNK20.60502935
114ADRBK10.60041563
115CAMKK20.59629505
116MAP3K120.57081855
117PRKCE0.56894953
118PRKCQ0.56775070
119CSF1R0.56248259
120STK110.55319217
121TSSK60.55231291
122LMTK20.55152238
123MAP2K10.54741290
124MAP2K70.54656507
125FGFR20.54249884
126PRKAA20.53417404
127MYLK0.52553470
128UHMK10.51490946
129EIF2AK20.51012315
130BLK0.50888868
131PINK10.50829835
132NTRK20.50017852
133PRKCZ0.49600606
134BRSK20.49473139
135LYN0.49016216
136JAK10.48545902
137IKBKB0.46402105
138LIMK10.46139199
139TAOK30.44832072
140PLK30.44723723
141SGK10.44513212
142BUB10.44052688
143TYK20.43308147
144PLK20.42642015
145AKT30.42288126
146MAP4K10.40870137
147PIM10.40070794
148ACVR1B0.39594386
149CSNK1G20.39490983
150PRKACA0.39097366
151MARK30.38329374
152SGK20.38186168
153CSNK1G30.36681174
154STK100.34893284
155LCK0.33559435
156CASK0.32075547
157PRKCD0.29339822

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.47927690
2Parkinsons disease_Homo sapiens_hsa050122.81444189
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.34244072
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.04027047
5Primary immunodeficiency_Homo sapiens_hsa053401.94788126
6Caffeine metabolism_Homo sapiens_hsa002321.92439891
7Protein export_Homo sapiens_hsa030601.92097655
8Type I diabetes mellitus_Homo sapiens_hsa049401.87558310
9Alzheimers disease_Homo sapiens_hsa050101.86487603
10GABAergic synapse_Homo sapiens_hsa047271.86048430
11Asthma_Homo sapiens_hsa053101.79546670
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.74200065
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.72660300
14Nicotine addiction_Homo sapiens_hsa050331.68383082
15Maturity onset diabetes of the young_Homo sapiens_hsa049501.67985248
16Synaptic vesicle cycle_Homo sapiens_hsa047211.65928796
17Huntingtons disease_Homo sapiens_hsa050161.63554127
18Proteasome_Homo sapiens_hsa030501.62796707
19Graft-versus-host disease_Homo sapiens_hsa053321.61901711
20Linoleic acid metabolism_Homo sapiens_hsa005911.55959625
21Glutamatergic synapse_Homo sapiens_hsa047241.55780417
22SNARE interactions in vesicular transport_Homo sapiens_hsa041301.55763731
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.54863449
24Allograft rejection_Homo sapiens_hsa053301.53272943
25Circadian entrainment_Homo sapiens_hsa047131.52875843
26Morphine addiction_Homo sapiens_hsa050321.52546319
27Autoimmune thyroid disease_Homo sapiens_hsa053201.47089374
28Olfactory transduction_Homo sapiens_hsa047401.43491144
29Antigen processing and presentation_Homo sapiens_hsa046121.41191721
30Renin secretion_Homo sapiens_hsa049241.40340711
31RNA polymerase_Homo sapiens_hsa030201.37651875
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.36076759
33Salivary secretion_Homo sapiens_hsa049701.34480777
34Regulation of autophagy_Homo sapiens_hsa041401.33148921
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.32064736
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.30782973
37Oxytocin signaling pathway_Homo sapiens_hsa049211.27649427
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.27449736
39Gastric acid secretion_Homo sapiens_hsa049711.26126235
40Phototransduction_Homo sapiens_hsa047441.25383437
41Cholinergic synapse_Homo sapiens_hsa047251.24212563
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.23934605
43Dilated cardiomyopathy_Homo sapiens_hsa054141.23576542
44Homologous recombination_Homo sapiens_hsa034401.22101804
45Nitrogen metabolism_Homo sapiens_hsa009101.20503035
46Serotonergic synapse_Homo sapiens_hsa047261.19691669
47Calcium signaling pathway_Homo sapiens_hsa040201.18749737
48Long-term potentiation_Homo sapiens_hsa047201.18534024
49Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.17926956
50Dopaminergic synapse_Homo sapiens_hsa047281.14796576
51Insulin secretion_Homo sapiens_hsa049111.14607216
52Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.14237072
53Fanconi anemia pathway_Homo sapiens_hsa034601.13861039
54Peroxisome_Homo sapiens_hsa041461.12571032
55Aldosterone synthesis and secretion_Homo sapiens_hsa049251.11910112
56Ribosome_Homo sapiens_hsa030101.11041269
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08908008
58Long-term depression_Homo sapiens_hsa047301.07752775
59Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.06906674
60Butanoate metabolism_Homo sapiens_hsa006501.06481274
61Folate biosynthesis_Homo sapiens_hsa007901.06356385
62Taste transduction_Homo sapiens_hsa047421.05748329
63Sulfur relay system_Homo sapiens_hsa041221.04465371
64Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.03479336
65Vascular smooth muscle contraction_Homo sapiens_hsa042701.02786671
66Amphetamine addiction_Homo sapiens_hsa050311.01876921
67Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.01815402
68cAMP signaling pathway_Homo sapiens_hsa040241.01089723
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00680325
70GnRH signaling pathway_Homo sapiens_hsa049120.99538651
71Fatty acid elongation_Homo sapiens_hsa000620.97712657
72Basal transcription factors_Homo sapiens_hsa030220.96804494
73Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.96678435
74Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.95994707
75Cocaine addiction_Homo sapiens_hsa050300.95056285
76Axon guidance_Homo sapiens_hsa043600.94486348
77Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.93630776
78Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.92165775
79cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91386380
80Cardiac muscle contraction_Homo sapiens_hsa042600.89742056
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89546491
82Pancreatic secretion_Homo sapiens_hsa049720.88815250
83Type II diabetes mellitus_Homo sapiens_hsa049300.87948086
84Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.86271473
85Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.84811061
86RNA degradation_Homo sapiens_hsa030180.82832461
87Chemical carcinogenesis_Homo sapiens_hsa052040.81329498
88Arachidonic acid metabolism_Homo sapiens_hsa005900.81125931
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.79962126
90Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.79126199
91Collecting duct acid secretion_Homo sapiens_hsa049660.78176100
92Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.76923300
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.75936882
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75463739
95Renal cell carcinoma_Homo sapiens_hsa052110.75118234
96Dorso-ventral axis formation_Homo sapiens_hsa043200.73556387
97Non-homologous end-joining_Homo sapiens_hsa034500.73240010
98Arginine biosynthesis_Homo sapiens_hsa002200.72677295
99beta-Alanine metabolism_Homo sapiens_hsa004100.71247263
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71189449
101Purine metabolism_Homo sapiens_hsa002300.70557385
102Ovarian steroidogenesis_Homo sapiens_hsa049130.70230247
103Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.69950045
104VEGF signaling pathway_Homo sapiens_hsa043700.68256964
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67533832
106Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67485070
107Bile secretion_Homo sapiens_hsa049760.67200150
108Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67116797
109Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.66317250
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.65856665
111Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.65527401
112ErbB signaling pathway_Homo sapiens_hsa040120.64719283
113Primary bile acid biosynthesis_Homo sapiens_hsa001200.63979174
114Hematopoietic cell lineage_Homo sapiens_hsa046400.63324747
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63239133
116Gap junction_Homo sapiens_hsa045400.62976163
117Ras signaling pathway_Homo sapiens_hsa040140.61653951
118Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61167551
119Ether lipid metabolism_Homo sapiens_hsa005650.58736419
120Selenocompound metabolism_Homo sapiens_hsa004500.58615277
121Nucleotide excision repair_Homo sapiens_hsa034200.57286133
122Fatty acid metabolism_Homo sapiens_hsa012120.57220640
123Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.57037453
124Glioma_Homo sapiens_hsa052140.56625147
125Propanoate metabolism_Homo sapiens_hsa006400.56587345
126Tryptophan metabolism_Homo sapiens_hsa003800.55380036
127MAPK signaling pathway_Homo sapiens_hsa040100.54983847
128Rap1 signaling pathway_Homo sapiens_hsa040150.54462212
129Fatty acid degradation_Homo sapiens_hsa000710.54224716
130Endocytosis_Homo sapiens_hsa041440.54212603
131Steroid hormone biosynthesis_Homo sapiens_hsa001400.53967297
132Estrogen signaling pathway_Homo sapiens_hsa049150.53669098
133Choline metabolism in cancer_Homo sapiens_hsa052310.53227972
134Complement and coagulation cascades_Homo sapiens_hsa046100.51282042
135Lysosome_Homo sapiens_hsa041420.49645109
136Adipocytokine signaling pathway_Homo sapiens_hsa049200.49440126
137Pyrimidine metabolism_Homo sapiens_hsa002400.49382299
138Metabolic pathways_Homo sapiens_hsa011000.48394440
139Rheumatoid arthritis_Homo sapiens_hsa053230.47136221
140Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46643996
141PPAR signaling pathway_Homo sapiens_hsa033200.46634609
142Staphylococcus aureus infection_Homo sapiens_hsa051500.45910459
143Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45767199
144Insulin resistance_Homo sapiens_hsa049310.45354139
145Platelet activation_Homo sapiens_hsa046110.45283058
146Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45256848
147Prion diseases_Homo sapiens_hsa050200.44488975
148Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.43820433
149Chemokine signaling pathway_Homo sapiens_hsa040620.43427740
150African trypanosomiasis_Homo sapiens_hsa051430.41850457
151Histidine metabolism_Homo sapiens_hsa003400.41161053
152Retinol metabolism_Homo sapiens_hsa008300.40144088
153Vibrio cholerae infection_Homo sapiens_hsa051100.39966340
154NOD-like receptor signaling pathway_Homo sapiens_hsa046210.39794381
155Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39178131
156Inositol phosphate metabolism_Homo sapiens_hsa005620.38398896
157Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38196665
158Thyroid hormone synthesis_Homo sapiens_hsa049180.37775392
159Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33922458
160Vitamin digestion and absorption_Homo sapiens_hsa049770.33222412
161Leishmaniasis_Homo sapiens_hsa051400.33148945
162One carbon pool by folate_Homo sapiens_hsa006700.31438389

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