SPOCK3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a novel family of calcium-binding proteoglycan proteins that contain thyroglobulin type-1 and Kazal-like domains. The encoded protein and may play a role in adult T-cell leukemia by inhibiting the activity of membrane-type matrix metalloproteinases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)5.70568087
2central nervous system myelination (GO:0022010)5.70568087
3cellular potassium ion homeostasis (GO:0030007)5.60739997
4synaptic vesicle docking involved in exocytosis (GO:0016081)5.37210369
5sodium ion export (GO:0071436)5.05040704
6vocalization behavior (GO:0071625)4.73457975
7neuron cell-cell adhesion (GO:0007158)4.71452001
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.68231241
9regulation of short-term neuronal synaptic plasticity (GO:0048172)4.62927355
10synaptic vesicle exocytosis (GO:0016079)4.50302989
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.43251893
12synaptic vesicle maturation (GO:0016188)4.41912146
13neuronal action potential propagation (GO:0019227)4.40815669
14potassium ion homeostasis (GO:0055075)4.19319118
15ionotropic glutamate receptor signaling pathway (GO:0035235)4.14683164
16protein localization to synapse (GO:0035418)4.13743865
17cerebellar granule cell differentiation (GO:0021707)4.12316171
18cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.09494356
19positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.05581713
20regulation of glutamate receptor signaling pathway (GO:1900449)4.03659627
21regulation of synapse structural plasticity (GO:0051823)4.00321267
22regulation of synaptic vesicle exocytosis (GO:2000300)3.96001163
23presynaptic membrane organization (GO:0097090)3.94144586
24presynaptic membrane assembly (GO:0097105)3.88445391
25neuron-neuron synaptic transmission (GO:0007270)3.86522149
26negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.83925536
27long-chain fatty acid biosynthetic process (GO:0042759)3.75900434
28glutamate receptor signaling pathway (GO:0007215)3.75404255
29neurotransmitter-gated ion channel clustering (GO:0072578)3.75380277
30transmission of nerve impulse (GO:0019226)3.74799216
31potassium ion import (GO:0010107)3.73476459
32neuron recognition (GO:0008038)3.70952406
33detection of calcium ion (GO:0005513)3.70312357
34regulation of neuronal synaptic plasticity (GO:0048168)3.69426923
35cellular sodium ion homeostasis (GO:0006883)3.68718914
36dendritic spine morphogenesis (GO:0060997)3.68294487
37gamma-aminobutyric acid transport (GO:0015812)3.68147335
38cerebellar Purkinje cell layer development (GO:0021680)3.65626084
39glutamate secretion (GO:0014047)3.65135310
40neurotransmitter secretion (GO:0007269)3.63684099
41regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.63545653
42regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.61709717
43regulation of long-term neuronal synaptic plasticity (GO:0048169)3.61653592
44locomotory exploration behavior (GO:0035641)3.60305312
45negative regulation of synaptic transmission, GABAergic (GO:0032229)3.58363925
46negative regulation of neurotransmitter transport (GO:0051589)3.58352880
47membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.58322616
48synaptic transmission, glutamatergic (GO:0035249)3.57576198
49synaptic transmission, dopaminergic (GO:0001963)3.55331548
50cell communication by electrical coupling (GO:0010644)3.51594010
51mechanosensory behavior (GO:0007638)3.50632145
52regulation of excitatory postsynaptic membrane potential (GO:0060079)3.48759024
53gamma-aminobutyric acid signaling pathway (GO:0007214)3.48702868
54prepulse inhibition (GO:0060134)3.45769662
55regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.45598578
56auditory behavior (GO:0031223)3.43343928
57behavioral response to cocaine (GO:0048148)3.41864201
58regulation of glutamate secretion (GO:0014048)3.38313561
59regulation of synaptic transmission, glutamatergic (GO:0051966)3.36677341
60regulation of synaptic vesicle transport (GO:1902803)3.35786006
61myelin maintenance (GO:0043217)3.35029502
62cerebellar Purkinje cell differentiation (GO:0021702)3.34163546
63proline transport (GO:0015824)3.32563258
64adult walking behavior (GO:0007628)3.31545728
65positive regulation of synapse maturation (GO:0090129)3.30621923
66membrane hyperpolarization (GO:0060081)3.27830795
67neurotransmitter transport (GO:0006836)3.27214438
68regulation of postsynaptic membrane potential (GO:0060078)3.25766384
69amino acid import (GO:0043090)3.25563448
70regulation of vesicle fusion (GO:0031338)3.25472341
71positive regulation of synaptic transmission, GABAergic (GO:0032230)3.25383750
72fatty acid elongation (GO:0030497)3.25274864
73mating behavior (GO:0007617)3.24471431
74positive regulation of membrane potential (GO:0045838)3.22883056
75layer formation in cerebral cortex (GO:0021819)3.22232614
76response to histamine (GO:0034776)3.21618571
77membrane depolarization during action potential (GO:0086010)3.21489750
78positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.21309154
79establishment of mitochondrion localization (GO:0051654)3.20866796
80glycine transport (GO:0015816)3.20079813
81long-term memory (GO:0007616)3.19721836
82positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.17560287
83neuronal ion channel clustering (GO:0045161)3.17175630
84startle response (GO:0001964)3.17112965
85axonal fasciculation (GO:0007413)3.16820290
86exploration behavior (GO:0035640)3.13637349
87response to auditory stimulus (GO:0010996)3.09709016
88long-term synaptic potentiation (GO:0060291)3.09160868
89regulation of neurotransmitter uptake (GO:0051580)3.08910751
90regulation of ARF protein signal transduction (GO:0032012)3.08585225
91neurofilament cytoskeleton organization (GO:0060052)3.07147449
92regulation of dendritic spine morphogenesis (GO:0061001)3.05323939
93striatum development (GO:0021756)3.05231606
94acidic amino acid transport (GO:0015800)3.04614174
95positive regulation of dendritic spine development (GO:0060999)3.04570411
96neuromuscular process controlling posture (GO:0050884)3.03573651
97chemosensory behavior (GO:0007635)3.03479205
98neurotransmitter uptake (GO:0001504)3.03162673
99regulation of neurotransmitter levels (GO:0001505)3.02694180
100synapse assembly (GO:0007416)3.01906710
101postsynaptic membrane organization (GO:0001941)3.01528883
102L-amino acid import (GO:0043092)3.01055380
103synaptic transmission (GO:0007268)2.99234609
104positive regulation of potassium ion transmembrane transport (GO:1901381)2.95690952
105regulation of synaptic plasticity (GO:0048167)2.94572963
106regulation of dopamine metabolic process (GO:0042053)2.94281887
107regulation of catecholamine metabolic process (GO:0042069)2.94281887
108cell communication involved in cardiac conduction (GO:0086065)2.94210353
109regulation of voltage-gated calcium channel activity (GO:1901385)2.93931983
110C4-dicarboxylate transport (GO:0015740)2.93676490
111positive regulation of synapse assembly (GO:0051965)2.92851886
112membrane depolarization (GO:0051899)2.92630387
113regulation of synaptic transmission, GABAergic (GO:0032228)2.88863131
114learning (GO:0007612)2.88642348
115G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.88441167
116regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.87814308
117regulation of neurotransmitter transport (GO:0051588)2.86657268
118synaptic vesicle endocytosis (GO:0048488)2.85338494
119positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.85324837
120cell differentiation in hindbrain (GO:0021533)2.84750388
121substantia nigra development (GO:0021762)2.84362302
122regulation of neurotransmitter secretion (GO:0046928)2.84358621
123regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.84088114
124regulation of protein kinase A signaling (GO:0010738)2.83353903
125glycosphingolipid biosynthetic process (GO:0006688)2.82815795
126negative regulation of amino acid transport (GO:0051956)2.80186436
127regulation of dendritic spine development (GO:0060998)2.79063476
128response to methylmercury (GO:0051597)2.79056108
129neuromuscular process controlling balance (GO:0050885)2.77887185
130myelination (GO:0042552)2.77866394
131adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.77539720
132negative regulation of neurotransmitter secretion (GO:0046929)2.77324194
133response to amphetamine (GO:0001975)2.76337778

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.50394538
2GBX2_23144817_ChIP-Seq_PC3_Human3.85818717
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.08465351
4* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.98660929
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.94207338
6TAF15_26573619_Chip-Seq_HEK293_Human2.62236730
7* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.53875198
8* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.51666299
9* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.51666299
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.51412047
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.48786067
12* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.47129389
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.40064569
14* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.38684276
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.36154971
16REST_21632747_ChIP-Seq_MESCs_Mouse2.29816870
17AR_21572438_ChIP-Seq_LNCaP_Human2.22490169
18* EED_16625203_ChIP-ChIP_MESCs_Mouse2.22016608
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.18513018
20RARB_27405468_Chip-Seq_BRAIN_Mouse2.14562658
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.10539702
22CTBP2_25329375_ChIP-Seq_LNCAP_Human2.08580339
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.02359664
24* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.02031305
25DROSHA_22980978_ChIP-Seq_HELA_Human1.97091521
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.95796563
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90296456
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.90001594
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.83956286
30* REST_18959480_ChIP-ChIP_MESCs_Mouse1.83713278
31SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.79760029
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76245916
33P300_19829295_ChIP-Seq_ESCs_Human1.66991332
34* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.66627379
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.66550438
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60210791
37SMAD4_21799915_ChIP-Seq_A2780_Human1.59590620
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58817558
39MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.57081216
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52848351
41* CBX2_27304074_Chip-Seq_ESCs_Mouse1.52068220
42CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.51170010
43IKZF1_21737484_ChIP-ChIP_HCT116_Human1.50296439
44* SMAD3_21741376_ChIP-Seq_EPCs_Human1.49614233
45RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.47389580
46PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.46672093
47* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.46436066
48* PIAS1_25552417_ChIP-Seq_VCAP_Human1.40385229
49* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38053133
50FUS_26573619_Chip-Seq_HEK293_Human1.37322401
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35177952
52RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34181284
53ER_23166858_ChIP-Seq_MCF-7_Human1.33014632
54VDR_22108803_ChIP-Seq_LS180_Human1.32869525
55CDX2_19796622_ChIP-Seq_MESCs_Mouse1.32529863
56RNF2_27304074_Chip-Seq_NSC_Mouse1.30411935
57* STAT3_23295773_ChIP-Seq_U87_Human1.28581186
58IGF1R_20145208_ChIP-Seq_DFB_Human1.27435757
59SOX2_21211035_ChIP-Seq_LN229_Gbm1.26137518
60UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24361932
61ERG_21242973_ChIP-ChIP_JURKAT_Human1.23351989
62* AR_25329375_ChIP-Seq_VCAP_Human1.22332314
63VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.21895885
64NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20204901
65HTT_18923047_ChIP-ChIP_STHdh_Human1.19005654
66TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18360245
67AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17394149
68FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.16283336
69P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14677286
70RING1B_27294783_Chip-Seq_ESCs_Mouse1.13031362
71TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12192333
72TCF4_23295773_ChIP-Seq_U87_Human1.11801415
73SMAD_19615063_ChIP-ChIP_OVARY_Human1.11774842
74TAL1_26923725_Chip-Seq_HPCs_Mouse1.10930712
75PRDM14_20953172_ChIP-Seq_ESCs_Human1.10400725
76ARNT_22903824_ChIP-Seq_MCF-7_Human1.09879454
77* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08469420
78RUNX2_22187159_ChIP-Seq_PCA_Human1.08308466
79CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.07706249
80ZNF274_21170338_ChIP-Seq_K562_Hela1.05231684
81AHR_22903824_ChIP-Seq_MCF-7_Human1.04062617
82NANOG_18555785_Chip-Seq_ESCs_Mouse1.03855727
83TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03145501
84NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02312414
85P53_22387025_ChIP-Seq_ESCs_Mouse1.00955297
86* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00291457
87RING1B_27294783_Chip-Seq_NPCs_Mouse1.00067342
88ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99744166
89FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99054728
90PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98536759
91* JUN_21703547_ChIP-Seq_K562_Human0.97902415
92WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96808781
93* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96771989
94AR_19668381_ChIP-Seq_PC3_Human0.96225248
95FLI1_27457419_Chip-Seq_LIVER_Mouse0.94506895
96TP53_18474530_ChIP-ChIP_U2OS_Human0.93048593
97YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92614203
98CMYC_18555785_Chip-Seq_ESCs_Mouse0.92086212
99KDM2B_26808549_Chip-Seq_REH_Human0.92016275
100* SMAD4_21741376_ChIP-Seq_HESCs_Human0.91432672
101STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.91242104
102DNAJC2_21179169_ChIP-ChIP_NT2_Human0.91099142
103SOX9_26525672_Chip-Seq_HEART_Mouse0.90218411
104CTNNB1_20460455_ChIP-Seq_HCT116_Human0.89779405
105PCGF2_27294783_Chip-Seq_ESCs_Mouse0.89323370
106CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88510202
107FLI1_21867929_ChIP-Seq_TH2_Mouse0.88146961
108RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.87876329
109EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.87650029
110EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.87515328
111E2F1_18555785_Chip-Seq_ESCs_Mouse0.85846869
112SMAD4_21741376_ChIP-Seq_EPCs_Human0.85459190
113MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.85293264
114TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84692443

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.93868209
2MP0004859_abnormal_synaptic_plasticity4.55116422
3MP0002822_catalepsy3.93809182
4MP0003635_abnormal_synaptic_transmissio3.67759884
5MP0004270_analgesia3.45077826
6MP0009745_abnormal_behavioral_response3.39450529
7MP0002064_seizures3.18452441
8MP0009046_muscle_twitch3.13539678
9MP0002063_abnormal_learning/memory/cond2.99900321
10MP0001529_abnormal_vocalization2.95288793
11MP0002272_abnormal_nervous_system2.95043921
12MP0005423_abnormal_somatic_nervous2.89321393
13MP0001968_abnormal_touch/_nociception2.79357276
14MP0001486_abnormal_startle_reflex2.76684738
15MP0002572_abnormal_emotion/affect_behav2.74653961
16MP0002734_abnormal_mechanical_nocicepti2.53726646
17MP0003329_amyloid_beta_deposits2.18659590
18MP0001501_abnormal_sleep_pattern2.14791158
19MP0000920_abnormal_myelination2.13682134
20MP0002735_abnormal_chemical_nociception2.12925026
21MP0002736_abnormal_nociception_after2.12572262
22MP0001970_abnormal_pain_threshold2.10999450
23MP0002733_abnormal_thermal_nociception2.05894087
24MP0001440_abnormal_grooming_behavior2.04520671
25MP0006276_abnormal_autonomic_nervous2.02927382
26MP0002067_abnormal_sensory_capabilities1.99066997
27MP0001905_abnormal_dopamine_level1.98537838
28MP0005386_behavior/neurological_phenoty1.92343138
29MP0004924_abnormal_behavior1.92343138
30MP0000778_abnormal_nervous_system1.88702762
31MP0004142_abnormal_muscle_tone1.87887017
32MP0008569_lethality_at_weaning1.80139230
33MP0002184_abnormal_innervation1.66839270
34MP0002557_abnormal_social/conspecific_i1.62762496
35MP0005645_abnormal_hypothalamus_physiol1.60514635
36MP0005646_abnormal_pituitary_gland1.56446281
37MP0004742_abnormal_vestibular_system1.55051844
38MP0004885_abnormal_endolymph1.54290088
39MP0002066_abnormal_motor_capabilities/c1.48090752
40MP0000955_abnormal_spinal_cord1.45236488
41MP0003690_abnormal_glial_cell1.45015131
42MP0003633_abnormal_nervous_system1.43860101
43MP0002882_abnormal_neuron_morphology1.42575666
44MP0001984_abnormal_olfaction1.41432180
45MP0004811_abnormal_neuron_physiology1.36079843
46MP0005409_darkened_coat_color1.35434511
47MP0003631_nervous_system_phenotype1.31635530
48MP0002229_neurodegeneration1.30736024
49MP0001188_hyperpigmentation1.29131222
50MP0003634_abnormal_glial_cell1.26214182
51MP0008877_abnormal_DNA_methylation1.22522580
52MP0003122_maternal_imprinting1.21639112
53MP0002909_abnormal_adrenal_gland1.19780181
54MP0003879_abnormal_hair_cell1.19522184
55MP0005551_abnormal_eye_electrophysiolog1.18781551
56MP0005171_absent_coat_pigmentation1.17431653
57MP0004858_abnormal_nervous_system1.11865044
58MP0001502_abnormal_circadian_rhythm1.11788294
59MP0000678_abnormal_parathyroid_gland1.11647523
60MP0004147_increased_porphyrin_level1.11584847
61MP0003632_abnormal_nervous_system1.06996661
62MP0000604_amyloidosis1.06157352
63MP0004043_abnormal_pH_regulation1.05770674
64MP0000569_abnormal_digit_pigmentation1.04235036
65MP0001177_atelectasis1.02548697
66MP0001485_abnormal_pinna_reflex1.01786426
67MP0003787_abnormal_imprinting1.01330542
68MP0002152_abnormal_brain_morphology1.00802103
69MP0009780_abnormal_chondrocyte_physiolo0.98458394
70MP0001963_abnormal_hearing_physiology0.97556279
71MP0008872_abnormal_physiological_respon0.96935186
72MP0005167_abnormal_blood-brain_barrier0.95729508
73MP0002752_abnormal_somatic_nervous0.92042741
74MP0008874_decreased_physiological_sensi0.89608778
75MP0004215_abnormal_myocardial_fiber0.88174728
76MP0002069_abnormal_eating/drinking_beha0.86701103
77MP0000751_myopathy0.85788825
78MP0002876_abnormal_thyroid_physiology0.85282986
79MP0005410_abnormal_fertilization0.84201744
80MP0000013_abnormal_adipose_tissue0.81070953
81MP0004085_abnormal_heartbeat0.80441181
82MP0005253_abnormal_eye_physiology0.77977926
83MP0003195_calcinosis0.77845715
84MP0002090_abnormal_vision0.76496659
85MP0010386_abnormal_urinary_bladder0.74353248
86MP0000631_abnormal_neuroendocrine_gland0.73802441
87MP0005535_abnormal_body_temperature0.73281634
88MP0002837_dystrophic_cardiac_calcinosis0.68547860
89MP0003121_genomic_imprinting0.67957039
90MP0003950_abnormal_plasma_membrane0.66532644
91MP0004145_abnormal_muscle_electrophysio0.65804308
92MP0001664_abnormal_digestion0.65145037
93MP0001765_abnormal_ion_homeostasis0.64389941
94MP0003137_abnormal_impulse_conducting0.63895928
95MP0000566_synostosis0.62684661
96MP0001943_abnormal_respiration0.61988262
97MP0000026_abnormal_inner_ear0.61967566
98MP0002638_abnormal_pupillary_reflex0.60758963
99MP0000639_abnormal_adrenal_gland0.60324509
100MP0005499_abnormal_olfactory_system0.59962516
101MP0005394_taste/olfaction_phenotype0.59962516
102MP0003075_altered_response_to0.59649324
103MP0001348_abnormal_lacrimal_gland0.59264402
104MP0001986_abnormal_taste_sensitivity0.59047815
105MP0003136_yellow_coat_color0.58615341
106MP0008260_abnormal_autophagy0.56575712
107MP0001299_abnormal_eye_distance/0.56468873
108MP0005623_abnormal_meninges_morphology0.54095451
109MP0000747_muscle_weakness0.53485371
110MP0004484_altered_response_of0.50186979
111MP0002082_postnatal_lethality0.49647192
112MP0010770_preweaning_lethality0.49647192
113MP0006072_abnormal_retinal_apoptosis0.49150837
114MP0005187_abnormal_penis_morphology0.48772671
115MP0010769_abnormal_survival0.48702422
116MP0003123_paternal_imprinting0.48625864
117MP0005195_abnormal_posterior_eye0.47933913

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.96788965
2Myokymia (HP:0002411)6.18004359
3Focal seizures (HP:0007359)4.90621794
4Neurofibrillary tangles (HP:0002185)4.38853139
5Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.23011586
6Degeneration of the lateral corticospinal tracts (HP:0002314)4.23011586
7Atonic seizures (HP:0010819)4.09717345
8Epileptic encephalopathy (HP:0200134)4.06962466
9Abnormality of the corticospinal tract (HP:0002492)3.81356046
10Ankle clonus (HP:0011448)3.75657290
11Supranuclear gaze palsy (HP:0000605)3.68031738
12Termporal pattern (HP:0011008)3.65306348
13Insidious onset (HP:0003587)3.65306348
14Febrile seizures (HP:0002373)3.62936053
15Cerebral inclusion bodies (HP:0100314)3.57515565
16Visual hallucinations (HP:0002367)3.46848740
17Absence seizures (HP:0002121)3.45755050
18Dialeptic seizures (HP:0011146)3.44451136
19Progressive cerebellar ataxia (HP:0002073)3.43977012
20Broad-based gait (HP:0002136)3.42037980
21Action tremor (HP:0002345)3.39258069
22Generalized tonic-clonic seizures (HP:0002069)3.26351119
23Limb dystonia (HP:0002451)3.21823660
24Spastic gait (HP:0002064)3.20044936
25Dysmetria (HP:0001310)3.17877307
26Hyperventilation (HP:0002883)3.15350350
27Hyperphosphatemia (HP:0002905)3.06213498
28Scanning speech (HP:0002168)2.99761993
29Dysdiadochokinesis (HP:0002075)2.88700893
30Pheochromocytoma (HP:0002666)2.83451722
31Poor eye contact (HP:0000817)2.82349584
32Tetany (HP:0001281)2.82247541
33Urinary urgency (HP:0000012)2.79097272
34Truncal ataxia (HP:0002078)2.79078914
35Peripheral hypomyelination (HP:0007182)2.77935117
36Anxiety (HP:0000739)2.77356286
37Increased circulating renin level (HP:0000848)2.75537054
38Onion bulb formation (HP:0003383)2.72906963
39Progressive inability to walk (HP:0002505)2.67513121
40Abnormal eating behavior (HP:0100738)2.65623730
41Impaired vibration sensation in the lower limbs (HP:0002166)2.64468808
42Morphological abnormality of the pyramidal tract (HP:0002062)2.63706962
43Urinary bladder sphincter dysfunction (HP:0002839)2.61732279
44Impaired social interactions (HP:0000735)2.60615762
45Abnormal social behavior (HP:0012433)2.60615762
46Torticollis (HP:0000473)2.58464083
47Gaze-evoked nystagmus (HP:0000640)2.56446703
48Neuroendocrine neoplasm (HP:0100634)2.51748055
49Status epilepticus (HP:0002133)2.51613456
50Intention tremor (HP:0002080)2.49694520
51Depression (HP:0000716)2.48573968
52Retinal dysplasia (HP:0007973)2.47419876
53Alacrima (HP:0000522)2.45411695
54Mutism (HP:0002300)2.44838465
55Sleep apnea (HP:0010535)2.43775765
56Lower limb muscle weakness (HP:0007340)2.40212294
57Impaired vibratory sensation (HP:0002495)2.38657566
58Dysmetric saccades (HP:0000641)2.37953518
59Split foot (HP:0001839)2.36979211
60Drooling (HP:0002307)2.36428573
61Excessive salivation (HP:0003781)2.36428573
62Focal dystonia (HP:0004373)2.32681498
63Polyphagia (HP:0002591)2.32616532
64Neuronal loss in central nervous system (HP:0002529)2.32301043
65Sensory axonal neuropathy (HP:0003390)2.27977573
66Impaired smooth pursuit (HP:0007772)2.26810448
67Hemiparesis (HP:0001269)2.26103466
68Craniofacial dystonia (HP:0012179)2.24731980
69Choreoathetosis (HP:0001266)2.24581066
70Diplopia (HP:0000651)2.24441828
71Abnormality of binocular vision (HP:0011514)2.24441828
72Hemiplegia (HP:0002301)2.22087619
73Leukodystrophy (HP:0002415)2.20761424
74Blue irides (HP:0000635)2.19589907
75Paraplegia (HP:0010550)2.17162120
76Gait imbalance (HP:0002141)2.15837624
77Decreased lacrimation (HP:0000633)2.14445474
78Clumsiness (HP:0002312)2.13782810
79Acute necrotizing encephalopathy (HP:0006965)2.11414634
80Generalized myoclonic seizures (HP:0002123)2.10966691
81Abnormality of ocular smooth pursuit (HP:0000617)2.10726859
82Postural instability (HP:0002172)2.08615805
83Spastic tetraparesis (HP:0001285)2.07923986
84Epileptiform EEG discharges (HP:0011182)2.07884379
85Clonus (HP:0002169)2.07832571
86Akinesia (HP:0002304)2.06102328
87Rigidity (HP:0002063)2.04520169
88Megalencephaly (HP:0001355)2.02886442
89EEG with generalized epileptiform discharges (HP:0011198)2.02249665
90Stridor (HP:0010307)2.01491863
91Absent speech (HP:0001344)2.00011571
92Progressive macrocephaly (HP:0004481)1.97746714
93Abnormality of calcium-phosphate metabolism (HP:0100530)1.97571038
94Specific learning disability (HP:0001328)1.96205163
95Resting tremor (HP:0002322)1.95476884
96Hypsarrhythmia (HP:0002521)1.95148582
97Aplasia involving bones of the extremities (HP:0009825)1.95123667
98Aplasia involving bones of the upper limbs (HP:0009823)1.95123667
99Aplasia of the phalanges of the hand (HP:0009802)1.95123667
100Amblyopia (HP:0000646)1.94831494
101Abnormal hair whorl (HP:0010721)1.94329980
102Papilledema (HP:0001085)1.94277831
103Psychosis (HP:0000709)1.92711664
104Postural tremor (HP:0002174)1.92052877
105Vaginal atresia (HP:0000148)1.91982274
106Abnormality of saccadic eye movements (HP:0000570)1.91679138
107Parakeratosis (HP:0001036)1.90860403
108Thickened helices (HP:0000391)1.89433622
109Genital tract atresia (HP:0001827)1.89371020
110Abnormal auditory evoked potentials (HP:0006958)1.89016991
111Spastic tetraplegia (HP:0002510)1.88984906
112Inability to walk (HP:0002540)1.88893550
113Syncope (HP:0001279)1.87760820
114Slow saccadic eye movements (HP:0000514)1.87092576
115Stereotypic behavior (HP:0000733)1.86572454
116Abnormal mitochondria in muscle tissue (HP:0008316)1.85428558
117Esotropia (HP:0000565)1.85287133
118Cerebral hypomyelination (HP:0006808)1.83908333
119Cerebral hemorrhage (HP:0001342)1.82692859
120Delusions (HP:0000746)1.82496218
121Fetal akinesia sequence (HP:0001989)1.82452501
122Bradykinesia (HP:0002067)1.82030692
123Gait ataxia (HP:0002066)1.81844453
124Bundle branch block (HP:0011710)1.80974546
125Autoamputation (HP:0001218)1.80865917
126Apathy (HP:0000741)1.80734058
127Rapidly progressive (HP:0003678)1.78646821
128Tetraplegia (HP:0002445)1.78051920
129Amyotrophic lateral sclerosis (HP:0007354)1.74945101
130Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.74541778
131Congenital primary aphakia (HP:0007707)1.74331283
132Congenital malformation of the right heart (HP:0011723)1.74003901
133Double outlet right ventricle (HP:0001719)1.74003901

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA43.57467409
2NTRK33.38212922
3CASK3.27880871
4MARK12.93072928
5MAP3K92.64238158
6MAP3K42.54287746
7STK392.52456921
8MAP2K72.31207333
9OXSR12.30888350
10NTRK12.16579696
11PNCK2.09228653
12NTRK22.07070569
13MINK11.92898234
14DAPK21.85806523
15MAPKAPK51.80964659
16TNIK1.71779664
17CDK191.69355694
18UHMK11.68946657
19CAMKK21.61631471
20PAK61.59534570
21KSR21.55132560
22MAPK131.54379578
23CDK51.46378852
24MAP4K21.41218432
25SGK4941.40603299
26SGK2231.40603299
27ARAF1.40315538
28MAP2K41.40153953
29PKN11.40002209
30MAP3K121.37164008
31CAMK2B1.34056305
32BCR1.33062411
33RIPK41.29411774
34GRK51.26643318
35MUSK1.23887342
36CAMK2A1.18274605
37FGFR21.17226473
38CAMKK11.14598328
39PLK21.13229905
40FES1.12284971
41WNK41.10527278
42KSR11.06152894
43WNK11.05840012
44CSNK1G21.03898503
45GRK71.02785461
46PRPF4B1.00549536
47PHKG20.99687132
48PHKG10.99687132
49FRK0.98037460
50SIK20.97422908
51PRKD30.97389852
52CAMK2D0.93137440
53CDK140.91968677
54EPHB10.90561795
55CDK180.89223582
56PRKCE0.89219377
57PRKCG0.89186268
58MAP3K20.87818982
59CDK150.87347849
60ERBB30.85375934
61CSNK1G30.84935363
62NEK60.83032896
63ROCK20.81122095
64MARK20.80690739
65BMPR20.80170917
66CAMK2G0.78875478
67FGR0.76864783
68TYRO30.76670766
69LIMK10.75246512
70CDK11A0.74746905
71TESK10.74556039
72PAK30.73013328
73MAP3K130.72886862
74CAMK1G0.71315516
75ADRBK20.69579067
76DYRK20.67400325
77STK110.67084210
78CAMK10.64892620
79CSNK1A1L0.64566069
80DAPK10.63814710
81DYRK1A0.63636886
82STK380.63178058
83SGK10.62384335
84MAPK100.61262391
85PINK10.57464403
86PDK20.55193106
87AKT30.54661572
88CSNK1D0.54431551
89NME10.54036625
90PRKCH0.53799608
91LATS20.53503239
92FYN0.51357923
93PDPK10.50777855
94CSNK1G10.49648523
95PTK2B0.49611566
96EPHA30.48427239
97ALK0.48102069
98PRKCA0.47780326
99ADRBK10.47049038
100SGK20.46356452
101TNK20.45886446
102CSNK1A10.45267993
103CAMK40.44984535
104WNK30.44771308
105DAPK30.44724110
106PRKACA0.44491154
107CSNK1E0.44489291
108RET0.44340445
109PRKG10.42297163
110PRKCZ0.42119817
111RAF10.41271912
112SGK30.41003030
113PRKD10.40560762
114MAP3K60.40461991
115PDK10.39350703
116MAPK120.39045745
117RPS6KA30.39045177
118FER0.38685420
119ERBB40.38353596
120PRKCB0.34693490

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.53819058
2Synaptic vesicle cycle_Homo sapiens_hsa047212.98806494
3GABAergic synapse_Homo sapiens_hsa047272.91618389
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.71149343
5Morphine addiction_Homo sapiens_hsa050322.63271781
6Glutamatergic synapse_Homo sapiens_hsa047242.50408451
7Olfactory transduction_Homo sapiens_hsa047402.47942871
8Circadian entrainment_Homo sapiens_hsa047132.35891710
9Amphetamine addiction_Homo sapiens_hsa050312.16259368
10Long-term potentiation_Homo sapiens_hsa047202.10027924
11Dopaminergic synapse_Homo sapiens_hsa047282.08791370
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.04702624
13Serotonergic synapse_Homo sapiens_hsa047262.03603829
14Cocaine addiction_Homo sapiens_hsa050302.00397192
15Collecting duct acid secretion_Homo sapiens_hsa049661.99364370
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.97550040
17Taste transduction_Homo sapiens_hsa047421.85811248
18Salivary secretion_Homo sapiens_hsa049701.81226308
19Cholinergic synapse_Homo sapiens_hsa047251.80975361
20Long-term depression_Homo sapiens_hsa047301.73381952
21Oxidative phosphorylation_Homo sapiens_hsa001901.69049619
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.65601394
23Gastric acid secretion_Homo sapiens_hsa049711.61164680
24Renin secretion_Homo sapiens_hsa049241.60467408
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.55142209
26Insulin secretion_Homo sapiens_hsa049111.49797936
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.40840167
28Parkinsons disease_Homo sapiens_hsa050121.40723933
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.39700796
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.36289966
31Calcium signaling pathway_Homo sapiens_hsa040201.35925533
32Alzheimers disease_Homo sapiens_hsa050101.30242254
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.30235840
34Oxytocin signaling pathway_Homo sapiens_hsa049211.30212147
35Vibrio cholerae infection_Homo sapiens_hsa051101.29017668
36Fatty acid elongation_Homo sapiens_hsa000621.28809783
37Axon guidance_Homo sapiens_hsa043601.27761998
38Cardiac muscle contraction_Homo sapiens_hsa042601.26759136
39Gap junction_Homo sapiens_hsa045401.24474746
40Phototransduction_Homo sapiens_hsa047441.17817963
41Ether lipid metabolism_Homo sapiens_hsa005651.16058595
42Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.13939801
43GnRH signaling pathway_Homo sapiens_hsa049121.06173584
44Butanoate metabolism_Homo sapiens_hsa006501.03132079
45Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.00407311
46Steroid biosynthesis_Homo sapiens_hsa001001.00195826
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.00016988
48cAMP signaling pathway_Homo sapiens_hsa040240.99848609
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.93507437
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91984763
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.89523129
52Circadian rhythm_Homo sapiens_hsa047100.89508973
53beta-Alanine metabolism_Homo sapiens_hsa004100.87639229
54Bile secretion_Homo sapiens_hsa049760.86247706
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84551725
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.83154693
57Nitrogen metabolism_Homo sapiens_hsa009100.82931518
58Arginine and proline metabolism_Homo sapiens_hsa003300.82651592
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.82421910
60Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81794367
61ErbB signaling pathway_Homo sapiens_hsa040120.81653540
62Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.79208186
63Estrogen signaling pathway_Homo sapiens_hsa049150.77278792
64Melanogenesis_Homo sapiens_hsa049160.77195423
65Dorso-ventral axis formation_Homo sapiens_hsa043200.76676805
66Mineral absorption_Homo sapiens_hsa049780.73338085
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73149667
68Arginine biosynthesis_Homo sapiens_hsa002200.72830563
69cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71912213
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.71085773
71Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.70944769
72Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70853094
73Huntingtons disease_Homo sapiens_hsa050160.69998195
74Pancreatic secretion_Homo sapiens_hsa049720.68133825
75Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.63795242
76Ras signaling pathway_Homo sapiens_hsa040140.63516377
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62839590
78Alcoholism_Homo sapiens_hsa050340.61534904
79Type II diabetes mellitus_Homo sapiens_hsa049300.61295967
80Type I diabetes mellitus_Homo sapiens_hsa049400.61157849
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.60905184
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60423238
83Regulation of autophagy_Homo sapiens_hsa041400.59838047
84Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.59483020
85Folate biosynthesis_Homo sapiens_hsa007900.58865986
86MAPK signaling pathway_Homo sapiens_hsa040100.57073720
87Rheumatoid arthritis_Homo sapiens_hsa053230.56654006
88Glioma_Homo sapiens_hsa052140.55564077
89Dilated cardiomyopathy_Homo sapiens_hsa054140.55238232
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53923454
91Renal cell carcinoma_Homo sapiens_hsa052110.51950937
92Glucagon signaling pathway_Homo sapiens_hsa049220.51882714
93Thyroid hormone synthesis_Homo sapiens_hsa049180.49159278
94Fatty acid biosynthesis_Homo sapiens_hsa000610.48507459
95Ovarian steroidogenesis_Homo sapiens_hsa049130.47687800
96Choline metabolism in cancer_Homo sapiens_hsa052310.46421891
97Sulfur metabolism_Homo sapiens_hsa009200.46249109
98Prion diseases_Homo sapiens_hsa050200.43604476
99Oocyte meiosis_Homo sapiens_hsa041140.42963012
100Rap1 signaling pathway_Homo sapiens_hsa040150.42895787
101African trypanosomiasis_Homo sapiens_hsa051430.42036626
102Sphingolipid metabolism_Homo sapiens_hsa006000.41864112
103Phagosome_Homo sapiens_hsa041450.40991007
104Tight junction_Homo sapiens_hsa045300.40686723
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39688628
106Vitamin B6 metabolism_Homo sapiens_hsa007500.39090724
107Endocytosis_Homo sapiens_hsa041440.38882236
108ABC transporters_Homo sapiens_hsa020100.37786873
109Inositol phosphate metabolism_Homo sapiens_hsa005620.37689245
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.37530141
111Histidine metabolism_Homo sapiens_hsa003400.36628947
112Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35711437
113Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35672346
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34612802
115Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32742943
116Chemokine signaling pathway_Homo sapiens_hsa040620.30216397
117Maturity onset diabetes of the young_Homo sapiens_hsa049500.23362455
118Primary bile acid biosynthesis_Homo sapiens_hsa001200.22493947

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