SPNS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a transporter of sphingosine 1-phosphate, a secreted lipid that is important in cardiovascular, immunological, and neural development. Defects in this gene are a cause of early onset progressive hearing loss. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinization (GO:0031424)5.99424013
2definitive hemopoiesis (GO:0060216)5.69602596
3synaptic vesicle docking involved in exocytosis (GO:0016081)5.13326019
4megakaryocyte development (GO:0035855)4.75875687
5negative regulation of erythrocyte differentiation (GO:0045647)4.75429433
6platelet dense granule organization (GO:0060155)4.67938635
7glutamate secretion (GO:0014047)4.66512407
8L-phenylalanine catabolic process (GO:0006559)4.38491964
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.38491964
10synaptic vesicle maturation (GO:0016188)4.32570266
11synaptic vesicle exocytosis (GO:0016079)4.22244532
12L-phenylalanine metabolic process (GO:0006558)4.11656742
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.11656742
14establishment of skin barrier (GO:0061436)4.11387655
15sodium ion export (GO:0071436)3.93575387
16antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.92179545
17antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.92179545
18endothelium development (GO:0003158)3.87084222
19regulation of short-term neuronal synaptic plasticity (GO:0048172)3.87076310
20desmosome organization (GO:0002934)3.86667615
21L-fucose catabolic process (GO:0042355)3.84056391
22fucose catabolic process (GO:0019317)3.84056391
23L-fucose metabolic process (GO:0042354)3.84056391
24cellular potassium ion homeostasis (GO:0030007)3.77539260
25regulation of water loss via skin (GO:0033561)3.71606250
26alpha-linolenic acid metabolic process (GO:0036109)3.68712686
27peptide cross-linking (GO:0018149)3.66771267
28positive regulation of respiratory burst (GO:0060267)3.58323028
29drug transmembrane transport (GO:0006855)3.55320517
30antigen processing and presentation via MHC class Ib (GO:0002475)3.49790909
31regulation of synaptic vesicle exocytosis (GO:2000300)3.49224434
32G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.46944283
33ethanol oxidation (GO:0006069)3.43141583
34positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.39190997
35myelin maintenance (GO:0043217)3.34919266
36positive regulation of synapse maturation (GO:0090129)3.34718722
37regulation of synapse structural plasticity (GO:0051823)3.32548212
38cysteine metabolic process (GO:0006534)3.30275917
39multicellular organismal water homeostasis (GO:0050891)3.29768969
40response to mercury ion (GO:0046689)3.28776247
41angiogenesis involved in wound healing (GO:0060055)3.28558878
42regulation of synapse maturation (GO:0090128)3.26875877
43thrombin receptor signaling pathway (GO:0070493)3.25764006
44neuronal ion channel clustering (GO:0045161)3.23826191
45secretory granule organization (GO:0033363)3.21975516
46fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.21966398
47mature B cell differentiation involved in immune response (GO:0002313)3.20410584
48phospholipid scrambling (GO:0017121)3.18405255
49neurotransmitter secretion (GO:0007269)3.16992554
50positive regulation of Rap GTPase activity (GO:0032854)3.16683704
51ribosomal small subunit assembly (GO:0000028)3.15070877
52sterol catabolic process (GO:0016127)3.15012893
53cholesterol catabolic process (GO:0006707)3.15012893
54L-amino acid import (GO:0043092)3.11382366
55vocalization behavior (GO:0071625)3.11215872
56aromatic amino acid family catabolic process (GO:0009074)3.09129296
57regulation of neuronal synaptic plasticity (GO:0048168)3.07633532
58Peyers patch development (GO:0048541)3.05957188
59mucosal-associated lymphoid tissue development (GO:0048537)3.05957188
60membrane tubulation (GO:0097320)3.04627168
61citrulline biosynthetic process (GO:0019240)3.03854818
62toxin transport (GO:1901998)3.02841001
63valine metabolic process (GO:0006573)3.02040811
64embryonic hemopoiesis (GO:0035162)3.01589160
65dendritic spine morphogenesis (GO:0060997)3.01585279
66bile acid biosynthetic process (GO:0006699)3.00494264
67drug transport (GO:0015893)3.00257336
68positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.97948853
69cell volume homeostasis (GO:0006884)2.96212224
70regulation of long-term neuronal synaptic plasticity (GO:0048169)2.96111059
71keratinocyte differentiation (GO:0030216)2.95948079
72antigen processing and presentation of endogenous antigen (GO:0019883)2.95806632
73blood coagulation, intrinsic pathway (GO:0007597)2.95023193
74cerebellar granule cell differentiation (GO:0021707)2.92761976
75regulation of ARF protein signal transduction (GO:0032012)2.91115969
76cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.90938694
77lysine metabolic process (GO:0006553)2.90738001
78lysine catabolic process (GO:0006554)2.90738001
79dendritic spine organization (GO:0097061)2.89354379
80glutamate metabolic process (GO:0006536)2.87641919
81regulation of synaptic vesicle transport (GO:1902803)2.87532950
82membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.86486709
83very long-chain fatty acid metabolic process (GO:0000038)2.83428647
84heparin metabolic process (GO:0030202)2.82112109
85heparin biosynthetic process (GO:0030210)2.82112109
86glomerular filtration (GO:0003094)2.81696129
87regulation of triglyceride catabolic process (GO:0010896)2.81002381
88mesodermal cell differentiation (GO:0048333)2.80469452
89semaphorin-plexin signaling pathway (GO:0071526)2.80184546
90response to interferon-beta (GO:0035456)2.79607849
91renal filtration (GO:0097205)2.78947162
92cell-cell junction maintenance (GO:0045217)2.78839899
93cell communication involved in cardiac conduction (GO:0086065)2.78399426
94hemidesmosome assembly (GO:0031581)2.77389680
95heme transport (GO:0015886)2.77286408
96regulation of respiratory burst (GO:0060263)2.77084430
97adenosine receptor signaling pathway (GO:0001973)2.77081359
98creatine metabolic process (GO:0006600)2.76454147
99response to interferon-alpha (GO:0035455)2.75942223
100positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.75726750
101opsonization (GO:0008228)2.73842196
102positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.72167840
103glyoxylate metabolic process (GO:0046487)2.71637878
104negative regulation of viral entry into host cell (GO:0046597)2.71580832
105bundle of His cell to Purkinje myocyte communication (GO:0086069)2.71249814
106water homeostasis (GO:0030104)2.70260647
107tricarboxylic acid metabolic process (GO:0072350)2.70110291
108regulation of glutamate receptor signaling pathway (GO:1900449)2.69829959
109regulation of erythrocyte differentiation (GO:0045646)2.68871103
110surfactant homeostasis (GO:0043129)2.68612312
111regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.67447485
112ionotropic glutamate receptor signaling pathway (GO:0035235)2.67061955
113amino acid import (GO:0043090)2.66597591
114dopamine receptor signaling pathway (GO:0007212)2.65931769
115regulation of Rap GTPase activity (GO:0032317)2.65559097
116quaternary ammonium group transport (GO:0015697)2.64691051
117phosphate ion transmembrane transport (GO:0035435)2.63599649
118regulation of neuron projection regeneration (GO:0070570)2.63351971
119regulation of axon regeneration (GO:0048679)2.63351971
120locomotory exploration behavior (GO:0035641)2.62819055
121epidermal cell differentiation (GO:0009913)2.61359626
122metanephric nephron epithelium development (GO:0072243)2.61196198
123layer formation in cerebral cortex (GO:0021819)2.60829201
124renal absorption (GO:0070293)2.58879116
125negative regulation of lipase activity (GO:0060192)2.58617047
126cell migration in hindbrain (GO:0021535)2.58201587
127positive regulation of B cell differentiation (GO:0045579)2.58070227
128potassium ion homeostasis (GO:0055075)2.57906200
129neuromuscular process controlling balance (GO:0050885)2.57813525
130amino-acid betaine metabolic process (GO:0006577)2.56877653
1312-oxoglutarate metabolic process (GO:0006103)2.55891070
132regulation of natural killer cell differentiation (GO:0032823)2.55189357
133growth hormone receptor signaling pathway (GO:0060396)2.53919462
134regulation of synaptic plasticity (GO:0048167)2.53671640
135urate metabolic process (GO:0046415)2.53639094
136positive regulation of triglyceride lipase activity (GO:0061365)2.53111931
137positive regulation of lipoprotein lipase activity (GO:0051006)2.53111931
138regulation of triglyceride metabolic process (GO:0090207)2.53108049
139regulation of clathrin-mediated endocytosis (GO:2000369)2.52396886
140kynurenine metabolic process (GO:0070189)2.52090418
141regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.51862781
142iron coordination entity transport (GO:1901678)2.51527330
143carnitine shuttle (GO:0006853)2.50764511
144activation of protein kinase A activity (GO:0034199)2.50507565
145regulation of ARF GTPase activity (GO:0032312)2.50281399
146branched-chain amino acid metabolic process (GO:0009081)2.49614687
147negative regulation of dendrite morphogenesis (GO:0050774)2.48822231
148triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.48049716
149regulation of cholesterol metabolic process (GO:0090181)2.47872611
150sulfur amino acid catabolic process (GO:0000098)2.47822706
151myeloid cell development (GO:0061515)2.47631427
152phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.45928541
153positive regulation of triglyceride metabolic process (GO:0090208)2.45617127
154neurotransmitter transport (GO:0006836)2.44788812
155peptidyl-tyrosine autophosphorylation (GO:0038083)2.44202050
156negative regulation of fibrinolysis (GO:0051918)2.43420710
157aspartate family amino acid catabolic process (GO:0009068)2.43176177
158cellular response to thyroid hormone stimulus (GO:0097067)2.42902095
159flavonoid metabolic process (GO:0009812)2.42888751
160potassium ion import (GO:0010107)2.42842175
161cellular sodium ion homeostasis (GO:0006883)2.42728133
162mannose metabolic process (GO:0006013)2.42659083
163bile acid metabolic process (GO:0008206)2.41722827
164fatty acid elongation (GO:0030497)2.41603995
165cytoskeletal anchoring at plasma membrane (GO:0007016)2.40935523
166metanephric epithelium development (GO:0072207)2.40514971
167short-chain fatty acid metabolic process (GO:0046459)2.40442695
168fatty acid transmembrane transport (GO:1902001)2.40398224
169positive regulation of Rac GTPase activity (GO:0032855)2.39785056
170central nervous system myelination (GO:0022010)2.39176283
171axon ensheathment in central nervous system (GO:0032291)2.39176283
172negative regulation of bone mineralization (GO:0030502)2.38471529
173granulocyte differentiation (GO:0030851)2.37901362
174arginine metabolic process (GO:0006525)2.37707910
175cell communication by electrical coupling (GO:0010644)2.36718368
176regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.35319539
177regulation of neurotransmitter levels (GO:0001505)2.35205863
178regulation of female receptivity (GO:0045924)2.33001451
179cell junction maintenance (GO:0034331)2.32831205
180long-chain fatty acid biosynthetic process (GO:0042759)2.29903203
181positive regulation of dendritic spine development (GO:0060999)2.28112305
182regulation of p38MAPK cascade (GO:1900744)2.28094262
183cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.27811299
184regulation of vesicle fusion (GO:0031338)2.27554979
185phosphate ion transport (GO:0006817)2.27512290
186cardiac conduction (GO:0061337)2.27416688
187actin filament capping (GO:0051693)2.23152690
188activation of Rac GTPase activity (GO:0032863)2.21791060
189chemical homeostasis within a tissue (GO:0048875)2.20402220
190neuron remodeling (GO:0016322)2.20035085
191endothelial cell chemotaxis (GO:0035767)2.20000297
192positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.19860971
193positive regulation of membrane potential (GO:0045838)2.19340781

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SCL_19346495_ChIP-Seq_HPC-7_Human5.60375440
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.98301675
3GATA1_22025678_ChIP-Seq_K562_Human3.87050379
4RXR_22158963_ChIP-Seq_LIVER_Mouse3.50276571
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.32643818
6PPARA_22158963_ChIP-Seq_LIVER_Mouse3.00379253
7EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.92035476
8RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.80975884
9* GATA2_21666600_ChIP-Seq_HMVEC_Human2.64374835
10ZNF263_19887448_ChIP-Seq_K562_Human2.63917353
11LXR_22158963_ChIP-Seq_LIVER_Mouse2.54839663
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.48581518
13GATA1_19941827_ChIP-Seq_MEL_Mouse2.43655274
14GATA1_19941826_ChIP-Seq_K562_Human2.43017416
15LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.42939615
16ESR2_21235772_ChIP-Seq_MCF-7_Human2.22889292
17* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.17173460
18STAT6_21828071_ChIP-Seq_BEAS2B_Human2.04454791
19TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.03571682
20ERG_21242973_ChIP-ChIP_JURKAT_Human1.98707496
21* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.95270427
22TCF7_22412390_ChIP-Seq_EML_Mouse1.92765706
23FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.92224234
24CTCF_27219007_Chip-Seq_Bcells_Human1.87345169
25RARB_27405468_Chip-Seq_BRAIN_Mouse1.85224964
26MYB_21317192_ChIP-Seq_ERMYB_Mouse1.84001452
27ELK3_25401928_ChIP-Seq_HUVEC_Human1.82291549
28EGR1_23403033_ChIP-Seq_LIVER_Mouse1.81454846
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.79240099
30GATA2_19941826_ChIP-Seq_K562_Human1.78527889
31* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.78275199
32* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.78156581
33* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.75069480
34MTF2_20144788_ChIP-Seq_MESCs_Mouse1.69975803
35LXR_22292898_ChIP-Seq_THP-1_Human1.68055594
36VDR_21846776_ChIP-Seq_THP-1_Human1.66901551
37JARID2_20075857_ChIP-Seq_MESCs_Mouse1.66260655
38* EZH2_27294783_Chip-Seq_ESCs_Mouse1.65589140
39MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.65034627
40* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.64362983
41EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.64275812
42* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.58762326
43SMC4_20622854_ChIP-Seq_HELA_Human1.54737525
44* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.54714195
45BP1_19119308_ChIP-ChIP_Hs578T_Human1.52994032
46MYC_22102868_ChIP-Seq_BL_Human1.52570830
47NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.52016080
48NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.51344826
49DNAJC2_21179169_ChIP-ChIP_NT2_Human1.48920184
50RNF2_27304074_Chip-Seq_ESCs_Mouse1.47990400
51ZFP281_18757296_ChIP-ChIP_E14_Mouse1.47307444
52CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.47128381
53RUNX1_27514584_Chip-Seq_MCF-7_Human1.46474243
54ESR1_21235772_ChIP-Seq_MCF-7_Human1.44835570
55CREB1_26743006_Chip-Seq_LNCaP_Human1.44289497
56RARG_19884340_ChIP-ChIP_MEFs_Mouse1.43393156
57UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.42197043
58SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.41053230
59EZH2_18974828_ChIP-Seq_MESCs_Mouse1.40950519
60RNF2_18974828_ChIP-Seq_MESCs_Mouse1.40950519
61SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.40632269
62CDX2_20551321_ChIP-Seq_CACO-2_Human1.40375631
63VDR_24763502_ChIP-Seq_THP-1_Human1.38572623
64STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.36828457
65STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.34176663
66KDM2B_26808549_Chip-Seq_DND41_Human1.34037840
67E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.33533954
68SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33204948
69TRIM28_21343339_ChIP-Seq_HEK293_Human1.31124629
70JARID2_20064375_ChIP-Seq_MESCs_Mouse1.29997499
71SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.29710148
72KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.29228166
73IRF8_22096565_ChIP-ChIP_GC-B_Human1.27817755
74TET1_21490601_ChIP-Seq_MESCs_Mouse1.27402922
75RACK7_27058665_Chip-Seq_MCF-7_Human1.26585685
76SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.26379972
77TET1_21451524_ChIP-Seq_MESCs_Mouse1.25692226
78RUNX1_22412390_ChIP-Seq_EML_Mouse1.25319691
79DROSHA_22980978_ChIP-Seq_HELA_Human1.24631180
80ZFP281_27345836_Chip-Seq_ESCs_Mouse1.24252420
81* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.24124659
82ESR1_20079471_ChIP-ChIP_T-47D_Human1.23638430
83SPI1_23127762_ChIP-Seq_K562_Human1.22878613
84SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.20862158
85MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.20809900
86TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20502548
87* MAF_26560356_Chip-Seq_TH1_Human1.18351157
88GATA2_22383799_ChIP-Seq_G1ME_Mouse1.17579312
89GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16802143
90RUNX_20019798_ChIP-Seq_JUKART_Human1.16237649
91SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.16007821
92VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.15504469
93NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.15275023
94CTCF_21964334_ChIP-Seq_BJAB-B_Human1.15264927
95REST_21632747_ChIP-Seq_MESCs_Mouse1.15223208
96IKZF1_21737484_ChIP-ChIP_HCT116_Human1.14228239
97GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13624328
98CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.13457103
99KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.13175165
100FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.12621200
101RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.12495213
102SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.12162752
103PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.10947986
104* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.10171824
105CLOCK_20551151_ChIP-Seq_293T_Human1.09553343
106FOXA2_19822575_ChIP-Seq_HepG2_Human1.08882185
107* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.07851819
108KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.06270709
109SRY_22984422_ChIP-ChIP_TESTIS_Rat1.05672490
110* P68_20966046_ChIP-Seq_HELA_Human1.05352345
111* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.05114564
112P63_26484246_Chip-Seq_KERATINOCYTES_Human1.04497355
113* KLF5_25053715_ChIP-Seq_YYC3_Human1.02963031
114EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.02270943
115TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.02176612
116PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02107410
117SA1_27219007_Chip-Seq_Bcells_Human1.01724396
118* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00378027
119JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.00298017
120BCL6_27268052_Chip-Seq_Bcells_Human1.00287631
121NCOR1_26117541_ChIP-Seq_K562_Human0.98971923
122WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.98859037
123* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98392950
124TP63_17297297_ChIP-ChIP_HaCaT_Human0.98116400
125BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.97899991
126SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97815076
127SOX9_24532713_ChIP-Seq_HFSC_Mouse0.97030162
128EZH2_27304074_Chip-Seq_ESCs_Mouse0.96769519
129* OCT4_19829295_ChIP-Seq_ESCs_Human0.96724376
130OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.95391919
131TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.95039893
132* KDM2B_26808549_Chip-Seq_K562_Human0.94982102
133* BCOR_27268052_Chip-Seq_Bcells_Human0.94671213
134SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94628435
135* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.94591076
136REST_18959480_ChIP-ChIP_MESCs_Mouse0.94443986
137* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.94238693
138RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.93816307
139NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.93457961
140KDM2B_26808549_Chip-Seq_JURKAT_Human0.92188177
141FOXO3_23340844_ChIP-Seq_DLD1_Human0.91384839
142GATA4_25053715_ChIP-Seq_YYC3_Human0.90943781
143SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.89775727
144CTCF_27219007_Chip-Seq_ERYTHROID_Human0.88190355
145CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.88024150
146UTX_26944678_Chip-Seq_JUKART_Human0.86877699
147AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.85619313
148SA1_27219007_Chip-Seq_ERYTHROID_Human0.85033142
149SOX2_20726797_ChIP-Seq_SW620_Human0.84033578
150CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.83838960
151IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.83611595
152PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.83188640
153* TP63_22573176_ChIP-Seq_HFKS_Human0.82937891

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.24265497
2MP0010368_abnormal_lymphatic_system3.90908360
3MP0005360_urolithiasis3.54602673
4MP0004147_increased_porphyrin_level3.35506363
5MP0005365_abnormal_bile_salt3.27109484
6MP0005085_abnormal_gallbladder_physiolo3.24954665
7MP0005423_abnormal_somatic_nervous2.97301511
8MP0008875_abnormal_xenobiotic_pharmacok2.75204288
9MP0003191_abnormal_cellular_cholesterol2.71666118
10MP0000465_gastrointestinal_hemorrhage2.63941387
11MP0003252_abnormal_bile_duct2.60741379
12MP0001666_abnormal_nutrient_absorption2.59932171
13MP0005167_abnormal_blood-brain_barrier2.52818703
14MP0005083_abnormal_biliary_tract2.49038725
15MP0004270_analgesia2.39216710
16MP0005464_abnormal_platelet_physiology2.33775397
17MP0010234_abnormal_vibrissa_follicle2.33438674
18MP0001188_hyperpigmentation2.31355523
19MP0003635_abnormal_synaptic_transmissio2.23795252
20MP0002138_abnormal_hepatobiliary_system2.23663551
21MP0001545_abnormal_hematopoietic_system2.21775016
22MP0005397_hematopoietic_system_phenotyp2.21775016
23MP0004782_abnormal_surfactant_physiolog2.13688227
24MP0003880_abnormal_central_pattern2.12896644
25MP0002396_abnormal_hematopoietic_system2.12176568
26MP0003656_abnormal_erythrocyte_physiolo2.08676067
27MP0004043_abnormal_pH_regulation2.03776467
28MP0009840_abnormal_foam_cell1.99011022
29MP0010329_abnormal_lipoprotein_level1.98045162
30MP0003300_gastrointestinal_ulcer1.95697772
31MP0001879_abnormal_lymphatic_vessel1.90451480
32MP0004808_abnormal_hematopoietic_stem1.90130725
33MP0004859_abnormal_synaptic_plasticity1.89616511
34MP0002064_seizures1.87537349
35MP0001502_abnormal_circadian_rhythm1.84753128
36MP0003868_abnormal_feces_composition1.82290526
37MP0003453_abnormal_keratinocyte_physiol1.79202419
38MP0003879_abnormal_hair_cell1.78934490
39MP0005275_abnormal_skin_tensile1.73484245
40MP0002796_impaired_skin_barrier1.71869278
41MP0005670_abnormal_white_adipose1.69672983
42MP0002063_abnormal_learning/memory/cond1.67898902
43MP0001486_abnormal_startle_reflex1.60743104
44MP0006054_spinal_hemorrhage1.60240267
45MP0005409_darkened_coat_color1.57770500
46MP0001501_abnormal_sleep_pattern1.57365052
47MP0005584_abnormal_enzyme/coenzyme_acti1.56029224
48MP0005084_abnormal_gallbladder_morpholo1.55418803
49MP0004130_abnormal_muscle_cell1.54785592
50MP0002118_abnormal_lipid_homeostasis1.54564161
51MP0003806_abnormal_nucleotide_metabolis1.51583059
52MP0009780_abnormal_chondrocyte_physiolo1.50988853
53MP0009278_abnormal_bone_marrow1.49396387
54MP0002272_abnormal_nervous_system1.44285277
55MP0001968_abnormal_touch/_nociception1.43484710
56MP0002098_abnormal_vibrissa_morphology1.43045416
57MP0000579_abnormal_nail_morphology1.41442624
58MP0000566_synostosis1.39128645
59MP0000920_abnormal_myelination1.37228298
60MP0003075_altered_response_to1.35920101
61MP0009745_abnormal_behavioral_response1.34453793
62MP0000013_abnormal_adipose_tissue1.33488851
63MP0003705_abnormal_hypodermis_morpholog1.31036366
64MP0004885_abnormal_endolymph1.30798795
65MP0005375_adipose_tissue_phenotype1.28905121
66MP0001765_abnormal_ion_homeostasis1.26507658
67MP0000747_muscle_weakness1.25862139
68MP0000003_abnormal_adipose_tissue1.25116613
69MP0003183_abnormal_peptide_metabolism1.24422707
70MP0003943_abnormal_hepatobiliary_system1.24411089
71MP0005319_abnormal_enzyme/_coenzyme1.24155324
72MP0001986_abnormal_taste_sensitivity1.23773572
73MP0005501_abnormal_skin_physiology1.23606486
74MP0002572_abnormal_emotion/affect_behav1.23482499
75MP0003690_abnormal_glial_cell1.22316969
76MP0005332_abnormal_amino_acid1.22161469
77MP0002733_abnormal_thermal_nociception1.19645460
78MP0002734_abnormal_mechanical_nocicepti1.19514495
79MP0001970_abnormal_pain_threshold1.19053135
80MP0010678_abnormal_skin_adnexa1.18747548
81MP0001756_abnormal_urination1.15864670
82MP0006036_abnormal_mitochondrial_physio1.15168293
83MP0002822_catalepsy1.15127607
84MP0003638_abnormal_response/metabolism_1.14766867
85MP0000467_abnormal_esophagus_morphology1.12424048
86MP0003303_peritoneal_inflammation1.12397485
87MP0005636_abnormal_mineral_homeostasis1.11611939
88MP0000609_abnormal_liver_physiology1.11345598
89MP0008874_decreased_physiological_sensi1.11234843
90MP0004019_abnormal_vitamin_homeostasis1.11195031
91MP0009643_abnormal_urine_homeostasis1.09012970
92MP0003566_abnormal_cell_adhesion1.08655227
93MP0005535_abnormal_body_temperature1.05271373
94MP0005220_abnormal_exocrine_pancreas1.04141384
95MP0005075_abnormal_melanosome_morpholog1.01161878
96MP0003045_fibrosis1.00998161
97MP0001216_abnormal_epidermal_layer1.00362306
98MP0009379_abnormal_foot_pigmentation0.99738602
99MP0003329_amyloid_beta_deposits0.99571889
100MP0003866_abnormal_defecation0.98037417
101MP0008569_lethality_at_weaning0.97315984
102MP0004036_abnormal_muscle_relaxation0.95218874
103MP0003724_increased_susceptibility_to0.94678635
104MP0003172_abnormal_lysosome_physiology0.94418005
105MP0009046_muscle_twitch0.94043619
106MP0001664_abnormal_digestion0.93205503
107MP0002089_abnormal_postnatal_growth/wei0.91121801
108MP0001177_atelectasis0.90479447
109MP0000598_abnormal_liver_morphology0.89963333
110MP0002735_abnormal_chemical_nociception0.89309539
111MP0010155_abnormal_intestine_physiology0.87552997
112MP0005058_abnormal_lysosome_morphology0.87089976
113MP0005174_abnormal_tail_pigmentation0.86990368
114MP0002928_abnormal_bile_duct0.86632000
115MP0004264_abnormal_extraembryonic_tissu0.85573787
116MP0010386_abnormal_urinary_bladder0.85202576
117MP0001873_stomach_inflammation0.84372703
118MP0000681_abnormal_thyroid_gland0.82953510
119MP0003631_nervous_system_phenotype0.82827070
120MP0005165_increased_susceptibility_to0.81613096
121MP0003634_abnormal_glial_cell0.80962311
122MP0006138_congestive_heart_failure0.78894027
123MP0000383_abnormal_hair_follicle0.76185938
124MP0004381_abnormal_hair_follicle0.76128224
125MP0000678_abnormal_parathyroid_gland0.76081653
126MP0004947_skin_inflammation0.75640180
127MP0008961_abnormal_basal_metabolism0.74818021
128MP0009931_abnormal_skin_appearance0.74639142
129MP0009765_abnormal_xenobiotic_induced0.74582166
130MP0000685_abnormal_immune_system0.73623219
131MP0008469_abnormal_protein_level0.73505091
132MP0001905_abnormal_dopamine_level0.72585276
133MP0010771_integument_phenotype0.72501059
134MP0005166_decreased_susceptibility_to0.71850144
135MP0000749_muscle_degeneration0.71081104
136MP0001881_abnormal_mammary_gland0.69914679
137MP0001440_abnormal_grooming_behavior0.68094884
138MP0000751_myopathy0.68074687
139MP0001849_ear_inflammation0.67933012
140MP0009764_decreased_sensitivity_to0.67699268
141MP0002066_abnormal_motor_capabilities/c0.67636944
142MP0002234_abnormal_pharynx_morphology0.66953156
143MP0003633_abnormal_nervous_system0.66728344
144MP0002128_abnormal_blood_circulation0.66557057
145MP0000462_abnormal_digestive_system0.65845446
146MP0000377_abnormal_hair_follicle0.64789511
147MP0009642_abnormal_blood_homeostasis0.64649872
148MP0004811_abnormal_neuron_physiology0.64398212
149MP0010352_gastrointestinal_tract_polyps0.63427856
150MP0004185_abnormal_adipocyte_glucose0.63132663
151MP0002971_abnormal_brown_adipose0.63108249
152MP0005666_abnormal_adipose_tissue0.62852598
153MP0002133_abnormal_respiratory_system0.62428184
154MP0001851_eye_inflammation0.62235011
155MP0001663_abnormal_digestive_system0.61499431
156MP0005025_abnormal_response_to0.60568472
157MP0008873_increased_physiological_sensi0.60383947
158MP0000249_abnormal_blood_vessel0.58865073
159MP0008872_abnormal_physiological_respon0.58693924
160MP0000343_altered_response_to0.58496064
161MP0009763_increased_sensitivity_to0.58133174

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.48389673
2Prolonged bleeding time (HP:0003010)4.28017240
3Abnormal platelet function (HP:0011869)4.24634775
4Impaired platelet aggregation (HP:0003540)4.24634775
5Obstructive sleep apnea (HP:0002870)4.21608423
6Petechiae (HP:0000967)3.93568167
7Thrombocytosis (HP:0001894)3.86808184
8Abnormality of aromatic amino acid family metabolism (HP:0004338)3.70734199
9Deep venous thrombosis (HP:0002625)3.59522084
10Abnormality of the heme biosynthetic pathway (HP:0010472)3.57155884
11Intrahepatic cholestasis (HP:0001406)3.45710661
12Annular pancreas (HP:0001734)3.34634180
13Epistaxis (HP:0000421)3.33223970
14Supranuclear gaze palsy (HP:0000605)3.27883378
15Abnormality of nail color (HP:0100643)3.26720959
16Hyperactive renin-angiotensin system (HP:0000841)3.25390592
17Menorrhagia (HP:0000132)3.21514203
18Polycythemia (HP:0001901)3.19933960
19Gingival bleeding (HP:0000225)3.13991099
20Chronic otitis media (HP:0000389)3.11366292
21Purpura (HP:0000979)3.06624193
22Neurofibrillary tangles (HP:0002185)3.02269065
23Acanthocytosis (HP:0001927)3.02164258
24Gout (HP:0001997)2.98095723
25Distal lower limb amyotrophy (HP:0008944)2.92107520
26Abnormal platelet volume (HP:0011876)2.89096048
27Increased mean platelet volume (HP:0011877)2.86631129
28Akinesia (HP:0002304)2.84605596
29Action tremor (HP:0002345)2.83478342
30Thin bony cortex (HP:0002753)2.73735053
31Interstitial pulmonary disease (HP:0006530)2.72539988
32Hyperlipoproteinemia (HP:0010980)2.66079278
33Distal upper limb amyotrophy (HP:0007149)2.65036784
34Upper limb amyotrophy (HP:0009129)2.65036784
35Microcytic anemia (HP:0001935)2.64812908
36Lower limb amyotrophy (HP:0007210)2.64253528
37Onycholysis (HP:0001806)2.63986514
38Abnormality of renin-angiotensin system (HP:0000847)2.62290098
39Palmoplantar hyperkeratosis (HP:0000972)2.58525806
40Abnormality of the nasal mucosa (HP:0000433)2.57663293
41Hypobetalipoproteinemia (HP:0003563)2.56730638
42Abnormality of binocular vision (HP:0011514)2.56685204
43Diplopia (HP:0000651)2.56685204
44Congenital ichthyosiform erythroderma (HP:0007431)2.55748012
45Increased circulating renin level (HP:0000848)2.55006852
46Focal motor seizures (HP:0011153)2.50320015
47Spontaneous abortion (HP:0005268)2.49473769
48Xanthomatosis (HP:0000991)2.48640809
49Poikilocytosis (HP:0004447)2.48626529
50Hyperbilirubinemia (HP:0002904)2.46366614
51Acanthosis nigricans (HP:0000956)2.45987183
52Cerebral inclusion bodies (HP:0100314)2.44701025
53Hypotrichosis (HP:0001006)2.44220174
54Axonal loss (HP:0003447)2.42103068
55Distal lower limb muscle weakness (HP:0009053)2.41928740
56Scanning speech (HP:0002168)2.41635290
57Abnormality of monocarboxylic acid metabolism (HP:0010996)2.39426670
58Epileptic encephalopathy (HP:0200134)2.34620876
59Nonprogressive disorder (HP:0003680)2.34062013
60Prolonged partial thromboplastin time (HP:0003645)2.34034010
61Spontaneous hematomas (HP:0007420)2.33501893
62Focal seizures (HP:0007359)2.32387061
63Milia (HP:0001056)2.31741504
64Palmar hyperkeratosis (HP:0010765)2.31271521
65Increased serum ferritin (HP:0003281)2.29452019
66Decreased circulating renin level (HP:0003351)2.28372136
67Metabolic alkalosis (HP:0200114)2.24225308
68Renal salt wasting (HP:0000127)2.23897243
69Pili torti (HP:0003777)2.23518537
70Glomerulosclerosis (HP:0000096)2.23238566
71Abnormality of chloride homeostasis (HP:0011422)2.20995577
72Plantar hyperkeratosis (HP:0007556)2.20945239
73Abnormality of the intrinsic pathway (HP:0010989)2.20679290
74Abnormal number of erythroid precursors (HP:0012131)2.20447982
75Pustule (HP:0200039)2.20214273
76Spastic gait (HP:0002064)2.18129393
77Erythema (HP:0010783)2.17628931
78Hyperaldosteronism (HP:0000859)2.17278615
79Polygenic inheritance (HP:0010982)2.16902507
80Fatigue (HP:0012378)2.16888115
81Ketosis (HP:0001946)2.15504486
82Hemorrhage of the eye (HP:0011885)2.14369712
83Abnormality of cells of the erythroid lineage (HP:0012130)2.14274535
84Cerebral aneurysm (HP:0004944)2.14269081
85Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.13292737
86Abnormal eating behavior (HP:0100738)2.12989861
87Dysmetria (HP:0001310)2.12620479
88Rapidly progressive (HP:0003678)2.10146955
89Muscle fiber splitting (HP:0003555)2.09565873
90Febrile seizures (HP:0002373)2.09545755
91Lip pit (HP:0100267)2.09493362
92Exercise-induced myalgia (HP:0003738)2.09336033
93Delayed CNS myelination (HP:0002188)2.06309926
94Hypokalemic alkalosis (HP:0001949)2.03939861
95Broad face (HP:0000283)2.03468762
96Dehydration (HP:0001944)2.02296584
97Esophageal varix (HP:0002040)2.02056478
98Onion bulb formation (HP:0003383)2.01753054
99Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.01518811
100Increased IgE level (HP:0003212)2.01275656
101Hypercholesterolemia (HP:0003124)1.99376139
102Spinal canal stenosis (HP:0003416)1.99271429
103Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.97833088
104Hyperkalemia (HP:0002153)1.97109642
105Papilledema (HP:0001085)1.96333764
106Foot dorsiflexor weakness (HP:0009027)1.94505886
107Abnormal atrioventricular conduction (HP:0005150)1.94380878
108Focal segmental glomerulosclerosis (HP:0000097)1.93239159
109Villous atrophy (HP:0011473)1.93164526
110Abnormality of small intestinal villus morphology (HP:0011472)1.93164526
111Abnormality of iron homeostasis (HP:0011031)1.92959773
112Sleep apnea (HP:0010535)1.91698996
113Fat malabsorption (HP:0002630)1.91665093
114Hyperammonemia (HP:0001987)1.91427613
115Neuronal loss in central nervous system (HP:0002529)1.90932154
116Postural instability (HP:0002172)1.90866710
117Spastic diplegia (HP:0001264)1.90127161
118Neonatal onset (HP:0003623)1.89275980
119Joint hemorrhage (HP:0005261)1.87382740
120Growth hormone excess (HP:0000845)1.86933035
121Heart block (HP:0012722)1.86641417
122Torticollis (HP:0000473)1.86262642
123Abnormal hair laboratory examination (HP:0003328)1.86093423
124Turricephaly (HP:0000262)1.85863396
125Abnormality of the periventricular white matter (HP:0002518)1.85543984
126Erythroderma (HP:0001019)1.83761811
127Malnutrition (HP:0004395)1.83555363
128Adrenal overactivity (HP:0002717)1.83429223
129Alopecia of scalp (HP:0002293)1.83115772
130Abnormality of purine metabolism (HP:0004352)1.81412604
131Hyperacusis (HP:0010780)1.80498092
132Visual hallucinations (HP:0002367)1.80302164
133Nemaline bodies (HP:0003798)1.79249808
134Loss of speech (HP:0002371)1.78932267
135Difficulty running (HP:0009046)1.78846037
136Woolly hair (HP:0002224)1.78738728
137Lower limb asymmetry (HP:0100559)1.78552283
138Abnormality of the lumbar spine (HP:0100712)1.78468501
139Aplastic anemia (HP:0001915)1.78221513
140Ventricular fibrillation (HP:0001663)1.78164211
141Cholecystitis (HP:0001082)1.77677918
142Abnormal gallbladder physiology (HP:0012438)1.77677918
143Hyporeflexia of lower limbs (HP:0002600)1.77255481
144Abnormality of the common coagulation pathway (HP:0010990)1.76751309
145Parakeratosis (HP:0001036)1.75954856
146Spastic paraparesis (HP:0002313)1.75894280
147Polar cataract (HP:0010696)1.75543380
148Bronchomalacia (HP:0002780)1.74791446
149Nail dystrophy (HP:0008404)1.74464766
150Abnormality of aspartate family amino acid metabolism (HP:0010899)1.73955028
151Intention tremor (HP:0002080)1.73409032
152Acute myeloid leukemia (HP:0004808)1.73399893
153Abnormality of fatty-acid metabolism (HP:0004359)1.73398244
154Cholelithiasis (HP:0001081)1.73116366
155Complement deficiency (HP:0004431)1.73041197
156Muscle fiber inclusion bodies (HP:0100299)1.72885646
157Stridor (HP:0010307)1.72337792
158Abnormality of the salivary glands (HP:0010286)1.72329025
159Abnormality of the foot musculature (HP:0001436)1.71963879
160Limb dystonia (HP:0002451)1.71621596
161Rigidity (HP:0002063)1.70951583
162Lymphangioma (HP:0100764)1.70831672
163Corneal erosion (HP:0200020)1.70688041
164Clonus (HP:0002169)1.70538195
165Cerebral hemorrhage (HP:0001342)1.69780548
166Abnormality of transition element cation homeostasis (HP:0011030)1.69356044
167Right ventricular cardiomyopathy (HP:0011663)1.68568882
168Broad metatarsal (HP:0001783)1.68228651
169Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.68147488
170Steatorrhea (HP:0002570)1.67968975
171Atrioventricular block (HP:0001678)1.67033937
172Abnormality of glutamine family amino acid metabolism (HP:0010902)1.66917282
173Ankle clonus (HP:0011448)1.66840302
174Thoracic kyphosis (HP:0002942)1.65452129
175Stroke (HP:0001297)1.65383631
176Gastrointestinal inflammation (HP:0004386)1.65132879
177Bruising susceptibility (HP:0000978)1.64136593
178Visceral angiomatosis (HP:0100761)1.63828179
179Cardiomegaly (HP:0001640)1.63547863
180IgM deficiency (HP:0002850)1.62833779
181Abnormality of skeletal muscle fiber size (HP:0012084)1.62819064
182Hemangiomatosis (HP:0007461)1.62346125
183Reduced antithrombin III activity (HP:0001976)1.61752136
184Abnormal delayed hypersensitivity skin test (HP:0002963)1.60933384

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE15.66007654
2MST1R3.49307084
3BCKDK3.09295195
4TGFBR22.97830778
5EEF2K2.79615117
6EPHB12.52112153
7PKN22.45611933
8MAPKAPK52.40868105
9LMTK22.27204006
10PRPF4B2.25723499
11CDK192.24796852
12MATK2.21648357
13TNIK2.13914468
14TGFBR12.03227894
15KDR2.01908457
16MAP4K11.97687081
17KIT1.97044075
18ERN11.88788327
19MAP2K31.84539735
20TRIB31.78610846
21PRKD31.73543369
22MAP3K71.69002414
23PAK61.68989416
24FES1.63694223
25NTRK11.59786725
26MAP3K61.58275648
27BTK1.55398182
28MUSK1.45779484
29SIK11.45341944
30MAP3K91.37991142
31MARK11.37234440
32FER1.36211896
33LRRK21.33757286
34MET1.31912657
35OXSR11.31367079
36MAPK151.28600462
37MAPKAPK31.27559299
38PIK3CG1.26981366
39PTK61.26547169
40UHMK11.21920693
41MAP3K111.20085548
42TAOK31.19084646
43SGK2231.17360121
44SGK4941.17360121
45PHKG21.16872661
46PHKG11.16872661
47MINK11.13798184
48RIPK41.12281486
49FGFR41.10003926
50NME21.09115105
51RET1.08553215
52MAP3K11.07009806
53TAOK11.06952424
54RPS6KB21.06900602
55FLT31.06181826
56RIPK11.05377635
57MAP2K61.03326538
58PRKG21.00806412
59IRAK21.00382203
60MAP3K20.99023511
61MAP2K40.98735082
62CAMK10.98678486
63NTRK30.98433881
64ICK0.97351699
65GRK50.95401458
66LATS20.93441714
67MARK20.90252216
68TTN0.87718853
69STK390.85408651
70EPHA40.85283441
71PINK10.84852641
72SGK30.83352649
73CAMKK10.82946046
74CDK50.81004002
75TESK10.80446212
76PDK10.79479366
77JAK30.78860707
78TBK10.77592361
79CSNK1G30.77419260
80WNK40.76375416
81EPHA20.75555861
82PRKD20.74129843
83CSNK1G20.72007020
84JAK20.70954065
85STK380.69211916
86CSF1R0.69032981
87PAK40.69007093
88SGK20.68917984
89PDPK10.67672318
90TYRO30.66507620
91PRKAA20.65999554
92MAP3K120.65934554
93EPHB20.64718245
94TNK20.63080435
95NTRK20.62716194
96HIPK20.61569520
97CSNK1G10.61425224
98PRKCH0.60839094
99TRPM70.60718120
100CDK120.60362956
101TEC0.60190067
102PIK3CA0.59623056
103PTK2B0.59264922
104ZAP700.58885098
105BMX0.58796357
106WNK10.57880246
107IRAK30.57077518
108MAPK40.56518358
109SGK10.55190125
110DAPK10.55099758
111STK110.55057428
112SYK0.54709071
113HCK0.54519319
114CAMK2G0.52625399
115SMG10.51760054
116MAP3K30.51364349
117MTOR0.50993963
118MAPK110.50278745
119PRKD10.49906798
120CSNK1A1L0.49462246
121MAPK70.48665795
122PKN10.48621202
123CAMKK20.48177014
124SIK20.47825484
125CDC42BPA0.46513251
126KSR20.45338970
127DAPK20.45263687
128DAPK30.44358190
129MAPK120.43807169
130NME10.42914543
131CCNB10.42700241
132CLK10.42401107
133PIM20.41982318
134CAMK2D0.41909545
135PAK20.41628716
136STK160.41406951
137MAPK100.40069261
138PTK20.37826992
139ERBB20.34529025
140CAMK2B0.34272672
141ALK0.34193659
142FGFR30.33862570
143RPS6KA20.32778676
144MAP3K130.32132308
145CAMK1G0.31248933
146MAP2K70.31159341
147FGFR20.30684712
148SRC0.30047388
149MAP2K20.29896739

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.27792937
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.21009023
3Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.77979106
4Caffeine metabolism_Homo sapiens_hsa002322.51198128
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.46493780
6Arginine biosynthesis_Homo sapiens_hsa002202.35777196
7Synaptic vesicle cycle_Homo sapiens_hsa047212.24152839
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.13703199
9Long-term potentiation_Homo sapiens_hsa047202.10221803
10Fatty acid degradation_Homo sapiens_hsa000711.93178605
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.91645412
12Propanoate metabolism_Homo sapiens_hsa006401.89364875
13Bile secretion_Homo sapiens_hsa049761.86315154
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.79319001
15Platelet activation_Homo sapiens_hsa046111.74935881
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.72667911
17Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.70024866
18ABC transporters_Homo sapiens_hsa020101.64488602
19Nicotine addiction_Homo sapiens_hsa050331.62077169
20Amphetamine addiction_Homo sapiens_hsa050311.60061725
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.55478633
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.55187410
23Complement and coagulation cascades_Homo sapiens_hsa046101.54043458
24Insulin secretion_Homo sapiens_hsa049111.53927440
25Fatty acid elongation_Homo sapiens_hsa000621.48230112
26Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.47173778
27Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.45777787
28Peroxisome_Homo sapiens_hsa041461.41031845
29Cocaine addiction_Homo sapiens_hsa050301.38051206
30PPAR signaling pathway_Homo sapiens_hsa033201.36982300
31Cyanoamino acid metabolism_Homo sapiens_hsa004601.33955713
32Phosphatidylinositol signaling system_Homo sapiens_hsa040701.33721197
33Folate biosynthesis_Homo sapiens_hsa007901.26628552
34Histidine metabolism_Homo sapiens_hsa003401.25554835
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.23695728
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.22597293
37Dopaminergic synapse_Homo sapiens_hsa047281.21720747
38Fatty acid metabolism_Homo sapiens_hsa012121.21198093
39Tryptophan metabolism_Homo sapiens_hsa003801.21028855
40Sulfur relay system_Homo sapiens_hsa041221.20259625
41Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.20259108
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.16951876
43Cholinergic synapse_Homo sapiens_hsa047251.16409008
44Estrogen signaling pathway_Homo sapiens_hsa049151.14691091
45Dorso-ventral axis formation_Homo sapiens_hsa043201.12478013
46Vitamin digestion and absorption_Homo sapiens_hsa049771.12456344
47Morphine addiction_Homo sapiens_hsa050321.11259225
48Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.09415348
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.07837816
50Inositol phosphate metabolism_Homo sapiens_hsa005621.05594979
51Pyruvate metabolism_Homo sapiens_hsa006201.05523651
52Butanoate metabolism_Homo sapiens_hsa006501.05322782
53beta-Alanine metabolism_Homo sapiens_hsa004101.04624978
54Fat digestion and absorption_Homo sapiens_hsa049751.04105263
55Pentose and glucuronate interconversions_Homo sapiens_hsa000401.02595366
56Vascular smooth muscle contraction_Homo sapiens_hsa042700.99472487
57Adipocytokine signaling pathway_Homo sapiens_hsa049200.98607044
58Chemical carcinogenesis_Homo sapiens_hsa052040.98058627
59Notch signaling pathway_Homo sapiens_hsa043300.97341009
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.95270861
61Collecting duct acid secretion_Homo sapiens_hsa049660.92990937
62Pancreatic secretion_Homo sapiens_hsa049720.91529415
63Glioma_Homo sapiens_hsa052140.90237639
64Choline metabolism in cancer_Homo sapiens_hsa052310.89874545
65Salivary secretion_Homo sapiens_hsa049700.89669452
66cAMP signaling pathway_Homo sapiens_hsa040240.89484883
67Glycerophospholipid metabolism_Homo sapiens_hsa005640.89361624
68Other glycan degradation_Homo sapiens_hsa005110.88331203
69ErbB signaling pathway_Homo sapiens_hsa040120.87382792
70Gastric acid secretion_Homo sapiens_hsa049710.87352826
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.87139575
72Gap junction_Homo sapiens_hsa045400.86133646
73B cell receptor signaling pathway_Homo sapiens_hsa046620.85280531
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.85155526
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82215476
76Glycerolipid metabolism_Homo sapiens_hsa005610.79627178
77ECM-receptor interaction_Homo sapiens_hsa045120.79046185
78Starch and sucrose metabolism_Homo sapiens_hsa005000.78100995
79Fructose and mannose metabolism_Homo sapiens_hsa000510.77641158
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77621895
81Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.77567266
82Glycosaminoglycan degradation_Homo sapiens_hsa005310.76365548
83Melanogenesis_Homo sapiens_hsa049160.76229050
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75683521
85Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.74976190
86Tight junction_Homo sapiens_hsa045300.74910784
87Sphingolipid metabolism_Homo sapiens_hsa006000.74800614
88Serotonergic synapse_Homo sapiens_hsa047260.74432623
89Axon guidance_Homo sapiens_hsa043600.73762806
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73143523
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.72711874
92Ras signaling pathway_Homo sapiens_hsa040140.72611668
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72250335
94Circadian entrainment_Homo sapiens_hsa047130.71899044
95Biosynthesis of amino acids_Homo sapiens_hsa012300.71865886
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.71179347
97Ether lipid metabolism_Homo sapiens_hsa005650.71102853
98Taste transduction_Homo sapiens_hsa047420.70412005
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.68930256
100Insulin resistance_Homo sapiens_hsa049310.67974323
101Aldosterone synthesis and secretion_Homo sapiens_hsa049250.67841694
102Glucagon signaling pathway_Homo sapiens_hsa049220.67663828
103MAPK signaling pathway_Homo sapiens_hsa040100.67499538
104Acute myeloid leukemia_Homo sapiens_hsa052210.67169904
105Ovarian steroidogenesis_Homo sapiens_hsa049130.66954059
106Insulin signaling pathway_Homo sapiens_hsa049100.65730330
107Renal cell carcinoma_Homo sapiens_hsa052110.65413360
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65095363
109Glutamatergic synapse_Homo sapiens_hsa047240.64876882
110Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64395402
111Phenylalanine metabolism_Homo sapiens_hsa003600.63373263
112Circadian rhythm_Homo sapiens_hsa047100.62061199
113Steroid hormone biosynthesis_Homo sapiens_hsa001400.61149853
114Vibrio cholerae infection_Homo sapiens_hsa051100.60297873
115mTOR signaling pathway_Homo sapiens_hsa041500.59927389
116Non-small cell lung cancer_Homo sapiens_hsa052230.59759481
117Arachidonic acid metabolism_Homo sapiens_hsa005900.59687915
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59250733
119Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.58791484
120Mineral absorption_Homo sapiens_hsa049780.55719928
121Leukocyte transendothelial migration_Homo sapiens_hsa046700.55589119
122Carbon metabolism_Homo sapiens_hsa012000.55394076
123AMPK signaling pathway_Homo sapiens_hsa041520.54667384
124Linoleic acid metabolism_Homo sapiens_hsa005910.54521790
125Pentose phosphate pathway_Homo sapiens_hsa000300.53935870
126Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.53154617
127SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52785400
128Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.52661730
129VEGF signaling pathway_Homo sapiens_hsa043700.52220054
130Retinol metabolism_Homo sapiens_hsa008300.52011267
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51059811
132Protein digestion and absorption_Homo sapiens_hsa049740.51006682
133Selenocompound metabolism_Homo sapiens_hsa004500.50606737
134Focal adhesion_Homo sapiens_hsa045100.49534026
135Chronic myeloid leukemia_Homo sapiens_hsa052200.47218202
136GnRH signaling pathway_Homo sapiens_hsa049120.43362503
137Thyroid cancer_Homo sapiens_hsa052160.43283247
138Lysine degradation_Homo sapiens_hsa003100.42550282
139Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41939534
140Long-term depression_Homo sapiens_hsa047300.41831623
141Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41711544
142Amoebiasis_Homo sapiens_hsa051460.41392410
143Phospholipase D signaling pathway_Homo sapiens_hsa040720.41342073
144Oxytocin signaling pathway_Homo sapiens_hsa049210.40859042
145Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.37668919
146Rap1 signaling pathway_Homo sapiens_hsa040150.37433002
147Calcium signaling pathway_Homo sapiens_hsa040200.37392613
148Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37363338
149Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37036188
150AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.35958650
151Arginine and proline metabolism_Homo sapiens_hsa003300.35533595
152Shigellosis_Homo sapiens_hsa051310.35338174
153Renin secretion_Homo sapiens_hsa049240.34608692
154Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34049385
155Staphylococcus aureus infection_Homo sapiens_hsa051500.33580917
156Endocytosis_Homo sapiens_hsa041440.33522409
157Hematopoietic cell lineage_Homo sapiens_hsa046400.32384496
158GABAergic synapse_Homo sapiens_hsa047270.32209965
159Thyroid hormone synthesis_Homo sapiens_hsa049180.30878727

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