SPNS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1purine nucleobase biosynthetic process (GO:0009113)6.76604931
2nucleobase biosynthetic process (GO:0046112)6.25260620
3folic acid metabolic process (GO:0046655)5.84248687
4ribosome assembly (GO:0042255)5.60824346
5ribosome biogenesis (GO:0042254)5.04634761
6folic acid transport (GO:0015884)5.04142754
7mitotic metaphase plate congression (GO:0007080)4.77156807
8vitamin transmembrane transport (GO:0035461)4.76982913
9formation of translation preinitiation complex (GO:0001731)4.60459137
10mannose metabolic process (GO:0006013)4.40264337
11DNA replication checkpoint (GO:0000076)4.37178512
12regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.29318470
13lung-associated mesenchyme development (GO:0060484)4.24125399
14rRNA modification (GO:0000154)4.20406554
15regulation of spindle organization (GO:0090224)4.18999165
16proteasome assembly (GO:0043248)4.15911279
17regulation of translation in response to stress (GO:0043555)3.97783910
18termination of RNA polymerase III transcription (GO:0006386)3.89072660
19transcription elongation from RNA polymerase III promoter (GO:0006385)3.89072660
20ribonucleoprotein complex biogenesis (GO:0022613)3.86430299
21anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.80034899
22regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.78921451
23negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.78808294
24spliceosomal snRNP assembly (GO:0000387)3.75300874
25maturation of SSU-rRNA (GO:0030490)3.74603157
26positive regulation of chromosome segregation (GO:0051984)3.71422609
27regulation of translational termination (GO:0006449)3.71398804
28NIK/NF-kappaB signaling (GO:0038061)3.68727747
29negative regulation of erythrocyte differentiation (GO:0045647)3.66980480
30positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.66775020
31regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.65114805
32glycine metabolic process (GO:0006544)3.64825263
33amino sugar catabolic process (GO:0046348)3.63590134
34blastocyst development (GO:0001824)3.61560985
35modified amino acid transport (GO:0072337)3.61276093
36negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.61059277
37amino acid salvage (GO:0043102)3.56934281
38L-methionine salvage (GO:0071267)3.56934281
39L-methionine biosynthetic process (GO:0071265)3.56934281
407-methylguanosine mRNA capping (GO:0006370)3.54936383
41rRNA processing (GO:0006364)3.53821701
42DNA replication initiation (GO:0006270)3.53637294
43DNA deamination (GO:0045006)3.52341110
44pantothenate metabolic process (GO:0015939)3.51074569
45transcription from RNA polymerase I promoter (GO:0006360)3.49902614
46pseudouridine synthesis (GO:0001522)3.48871052
47regulation of mitotic spindle organization (GO:0060236)3.47373998
48metaphase plate congression (GO:0051310)3.46562336
49response to peptidoglycan (GO:0032494)3.46146465
50rRNA metabolic process (GO:0016072)3.43304436
51transcription elongation from RNA polymerase I promoter (GO:0006362)3.43296095
527-methylguanosine RNA capping (GO:0009452)3.41417833
53RNA capping (GO:0036260)3.41417833
54L-serine metabolic process (GO:0006563)3.41017110
55protein localization to kinetochore (GO:0034501)3.40621312
56positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.39237750
57termination of RNA polymerase I transcription (GO:0006363)3.38077535
58negative regulation of interleukin-12 production (GO:0032695)3.35471876
59regulation of gene silencing by RNA (GO:0060966)3.32494862
60regulation of posttranscriptional gene silencing (GO:0060147)3.32494862
61regulation of gene silencing by miRNA (GO:0060964)3.32494862
62GMP metabolic process (GO:0046037)3.32225679
63histone arginine methylation (GO:0034969)3.31175867
64negative regulation of ligase activity (GO:0051352)3.30636912
65negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.30636912
66lysosome organization (GO:0007040)3.28886920
67lytic vacuole organization (GO:0080171)3.28886920
68methionine biosynthetic process (GO:0009086)3.28844173
69mitotic nuclear envelope disassembly (GO:0007077)3.28047038
70intestinal epithelial cell development (GO:0060576)3.27519147
71amyloid precursor protein catabolic process (GO:0042987)3.25613325
72cellular response to thyroid hormone stimulus (GO:0097067)3.23603523
73mitotic sister chromatid segregation (GO:0000070)3.23521574
74aspartate family amino acid biosynthetic process (GO:0009067)3.19981796
75autophagic vacuole assembly (GO:0000045)3.19508058
76CDP-diacylglycerol metabolic process (GO:0046341)3.18224822
77negative regulation of chromosome segregation (GO:0051985)3.17797826
78ribosomal large subunit biogenesis (GO:0042273)3.17740969
79mitotic G1 DNA damage checkpoint (GO:0031571)3.17067392
80glycosphingolipid catabolic process (GO:0046479)3.16865109
81positive regulation of ligase activity (GO:0051351)3.14861964
82establishment of protein localization to mitochondrial membrane (GO:0090151)3.12525563
83barbed-end actin filament capping (GO:0051016)3.12424269
84regulation of G0 to G1 transition (GO:0070316)3.12357658
85transcription initiation from RNA polymerase I promoter (GO:0006361)3.10371482
86rRNA methylation (GO:0031167)3.10032043
87regulation of chromosome segregation (GO:0051983)3.08056780
88hyaluronan catabolic process (GO:0030214)3.07985569
89negative regulation of translational initiation (GO:0045947)3.07853827
90transcription from mitochondrial promoter (GO:0006390)3.07848706
91mitotic spindle checkpoint (GO:0071174)3.07553215
92maturation of 5.8S rRNA (GO:0000460)3.05711395
93regulation of ubiquitin-protein transferase activity (GO:0051438)3.05536506
94regulation of nuclear cell cycle DNA replication (GO:0033262)3.05096458
95IMP biosynthetic process (GO:0006188)3.04713257
96UV protection (GO:0009650)3.04236147
97nuclear envelope disassembly (GO:0051081)3.03722087
98membrane disassembly (GO:0030397)3.03722087
99mitotic spindle assembly checkpoint (GO:0007094)3.03478616
100spindle checkpoint (GO:0031577)3.03437203
101L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.03269350
102negative regulation of mitotic sister chromatid separation (GO:2000816)3.03144456
103negative regulation of mitotic sister chromatid segregation (GO:0033048)3.03144456
104negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.03144456
105negative regulation of sister chromatid segregation (GO:0033046)3.03144456
106methionine metabolic process (GO:0006555)3.01752478
107DNA strand elongation involved in DNA replication (GO:0006271)3.01636534
108positive regulation of viral transcription (GO:0050434)3.01232741
109negative regulation of macroautophagy (GO:0016242)2.98146486
110N-acetylneuraminate metabolic process (GO:0006054)2.97963953
111mitotic G1/S transition checkpoint (GO:0044819)2.96361717
112negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.91816768
113spindle assembly checkpoint (GO:0071173)2.91329740
114regulation of mast cell degranulation (GO:0043304)2.91282478
115cullin deneddylation (GO:0010388)2.91271334
116peptidyl-arginine omega-N-methylation (GO:0035247)2.89705106
117cellular component biogenesis (GO:0044085)2.89282974
118DNA replication-dependent nucleosome assembly (GO:0006335)2.88765242
119neutrophil activation involved in immune response (GO:0002283)2.88055764
120adhesion of symbiont to host (GO:0044406)2.86958652
121lipopolysaccharide-mediated signaling pathway (GO:0031663)2.86830621
122negative regulation of tumor necrosis factor production (GO:0032720)2.85097800
123cellular response to arsenic-containing substance (GO:0071243)2.83464011
124low-density lipoprotein particle clearance (GO:0034383)2.82800240
125adhesion of symbiont to host cell (GO:0044650)2.82065813
126virion attachment to host cell (GO:0019062)2.82065813
127glycolipid catabolic process (GO:0019377)2.81359820
128response to thyroid hormone (GO:0097066)2.78082132
129regulation of cholesterol storage (GO:0010885)2.77448343
130negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.75920545
131regulation of leukocyte degranulation (GO:0043300)2.73378643
132negative regulation of granulocyte differentiation (GO:0030853)2.72971681
133tooth mineralization (GO:0034505)2.69738917
134positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.67397506
135negative regulation of nitric oxide biosynthetic process (GO:0045019)2.63437432
136regulation of monocyte differentiation (GO:0045655)2.62192118
137regulation of myeloid leukocyte mediated immunity (GO:0002886)2.57852301
138regulation of mast cell activation involved in immune response (GO:0033006)2.57384440
139ceramide catabolic process (GO:0046514)2.56572100
140oligosaccharide catabolic process (GO:0009313)2.55522771
141modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.55279867
142positive regulation by organism of defense response of other organism involved in symbiotic interact2.55279867
143modulation by symbiont of host immune response (GO:0052553)2.55279867
144positive regulation by symbiont of host defense response (GO:0052509)2.55279867
145modulation by symbiont of host defense response (GO:0052031)2.55279867
146modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.55279867
147sphingolipid catabolic process (GO:0030149)2.55135705
148positive regulation of gamma-delta T cell activation (GO:0046645)2.54877399
149pinocytosis (GO:0006907)2.54768595
150pentose metabolic process (GO:0019321)2.53656366
151negative regulation of myeloid cell apoptotic process (GO:0033033)2.53564529
152negative regulation of cytokine production involved in immune response (GO:0002719)2.52566980
153membrane lipid catabolic process (GO:0046466)2.51172768
154pentose-phosphate shunt (GO:0006098)2.49412620
155regulation of mononuclear cell migration (GO:0071675)2.47929904
156negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.43370711
157positive regulation of lymphocyte apoptotic process (GO:0070230)2.42076536
158regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)2.41571050
159response to muramyl dipeptide (GO:0032495)2.40317028
160regulation of apoptotic process involved in morphogenesis (GO:1902337)2.39225129
161regulation of tumor necrosis factor production (GO:0032680)2.38043431
162positive regulation of histone deacetylation (GO:0031065)2.35805362
163autophagic vacuole fusion (GO:0000046)2.33951550
164regulation of mast cell activation (GO:0033003)2.32161202
165phagosome maturation (GO:0090382)2.31228353
166regulation of membrane protein ectodomain proteolysis (GO:0051043)2.30937560
167granulocyte activation (GO:0036230)2.30882495
168negative regulation of cell killing (GO:0031342)2.30668257
169negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.30668257
170positive regulation of mast cell activation (GO:0033005)2.30534704
171positive regulation of hair cycle (GO:0042635)2.29763555
172positive regulation of hair follicle development (GO:0051798)2.29763555
173proline biosynthetic process (GO:0006561)2.29701880
174plasma lipoprotein particle clearance (GO:0034381)2.29003416
175endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.28891571
176regulation of gamma-delta T cell activation (GO:0046643)2.28289077
177decidualization (GO:0046697)2.26919626
178glucose catabolic process (GO:0006007)2.22958305
179positive regulation of cholesterol efflux (GO:0010875)2.22126630
180regulation of autophagic vacuole assembly (GO:2000785)2.21326817
181L-alpha-amino acid transmembrane transport (GO:1902475)2.20603927
182glial cell migration (GO:0008347)2.20586915
183endothelium development (GO:0003158)2.20185538
184positive regulation of chemokine biosynthetic process (GO:0045080)2.19783657
185positive regulation of T cell mediated cytotoxicity (GO:0001916)2.19468482
186negative regulation of cell size (GO:0045792)2.19317092
187virion assembly (GO:0019068)2.18692247
188fat-soluble vitamin biosynthetic process (GO:0042362)2.17972664
189negative regulation of innate immune response (GO:0045824)2.17242037
190regulation of T cell mediated cytotoxicity (GO:0001914)2.16680352
191negative regulation of interleukin-6 production (GO:0032715)2.16296784
192myeloid dendritic cell differentiation (GO:0043011)2.16198725
193regulation of natural killer cell mediated immunity (GO:0002715)2.15577408
194regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.15577408
195tolerance induction (GO:0002507)2.14512124
196immunoglobulin mediated immune response (GO:0016064)2.14422325
1973-UTR-mediated mRNA stabilization (GO:0070935)2.14256737
198keratan sulfate catabolic process (GO:0042340)2.13803928
199negative regulation of interleukin-2 production (GO:0032703)2.13549858
200vacuole organization (GO:0007033)2.13084316

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.71769132
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.84134820
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.45090787
4* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.33801945
5* ETS1_20019798_ChIP-Seq_JURKAT_Human3.25992023
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.18200128
7MYC_19079543_ChIP-ChIP_MESCs_Mouse3.09097456
8CREB1_15753290_ChIP-ChIP_HEK293T_Human2.99506323
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.99372921
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.94850782
11VDR_21846776_ChIP-Seq_THP-1_Human2.91223629
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.90081229
13LXR_22292898_ChIP-Seq_THP-1_Human2.79145424
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.78184084
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.71287458
16NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.67536823
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.65011081
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.59659287
19NANOG_18555785_ChIP-Seq_MESCs_Mouse2.55525002
20ELK3_25401928_ChIP-Seq_HUVEC_Human2.53312585
21POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.39950016
22* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.25012028
23YY1_21170310_ChIP-Seq_MESCs_Mouse2.23757809
24PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.21044653
25BP1_19119308_ChIP-ChIP_Hs578T_Human2.20085941
26NELFA_20434984_ChIP-Seq_ESCs_Mouse2.18154408
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.16448349
28RARG_19884340_ChIP-ChIP_MEFs_Mouse2.15334219
29IRF8_22096565_ChIP-ChIP_GC-B_Human2.12169157
30TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.11796087
31THAP11_20581084_ChIP-Seq_MESCs_Mouse2.11629797
32XRN2_22483619_ChIP-Seq_HELA_Human2.09748133
33E2F4_17652178_ChIP-ChIP_JURKAT_Human2.09350491
34HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.07007354
35KDM2B_26808549_Chip-Seq_SUP-B15_Human2.06003982
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.03856818
37E2F1_18555785_ChIP-Seq_MESCs_Mouse2.02607610
38SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.02167930
39MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.01289230
40P68_20966046_ChIP-Seq_HELA_Human1.98924596
41NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.98301036
42FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.97880608
43CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.97785212
44VDR_23849224_ChIP-Seq_CD4+_Human1.94232346
45ELF1_20517297_ChIP-Seq_JURKAT_Human1.93816284
46KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.93666930
47GABP_19822575_ChIP-Seq_HepG2_Human1.92060341
48CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.84817369
49KDM2B_26808549_Chip-Seq_DND41_Human1.82211420
50MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78256557
51* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.77811283
52AR_21909140_ChIP-Seq_LNCAP_Human1.77503652
53BCOR_27268052_Chip-Seq_Bcells_Human1.77250828
54NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.76696179
55RACK7_27058665_Chip-Seq_MCF-7_Human1.75730834
56BCL6_27268052_Chip-Seq_Bcells_Human1.75404341
57E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.74817100
58IRF8_21731497_ChIP-ChIP_J774_Mouse1.74034414
59* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.70468644
60ZNF263_19887448_ChIP-Seq_K562_Human1.70112646
61KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.67654660
62VDR_24763502_ChIP-Seq_THP-1_Human1.66127978
63FOXP3_21729870_ChIP-Seq_TREG_Human1.64576070
64STAT3_1855785_ChIP-Seq_MESCs_Mouse1.64471783
65DCP1A_22483619_ChIP-Seq_HELA_Human1.63934322
66NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.63750681
67* TET1_21451524_ChIP-Seq_MESCs_Mouse1.63201693
68MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.60491700
69MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.60392415
70KDM5A_27292631_Chip-Seq_BREAST_Human1.59607183
71KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.59169741
72KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.59169741
73KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.59169741
74SA1_27219007_Chip-Seq_ERYTHROID_Human1.53729259
75KLF4_18555785_ChIP-Seq_MESCs_Mouse1.53224902
76UTX_26944678_Chip-Seq_JUKART_Human1.53117392
77RUNX1_22412390_ChIP-Seq_EML_Mouse1.52189109
78TCF3_18692474_ChIP-Seq_MEFs_Mouse1.52039399
79TTF2_22483619_ChIP-Seq_HELA_Human1.51800299
80ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.50489530
81TP63_17297297_ChIP-ChIP_HaCaT_Human1.49782218
82POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.49633308
83MAF_26560356_Chip-Seq_TH1_Human1.49475604
84CTCF_27219007_Chip-Seq_ERYTHROID_Human1.48298084
85RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.48148896
86TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.47536235
87* MAF_26560356_Chip-Seq_TH2_Human1.46562983
88CIITA_25753668_ChIP-Seq_RAJI_Human1.45151484
89SMC4_20622854_ChIP-Seq_HELA_Human1.44147983
90* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.43357870
91TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.43141705
92SCL_19346495_ChIP-Seq_HPC-7_Human1.42559259
93* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42149235
94TCF7_22412390_ChIP-Seq_EML_Mouse1.42042738
95LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.42000452
96PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.40830665
97SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.40022473
98STAT4_19710469_ChIP-ChIP_TH1__Mouse1.39656409
99* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.39260921
100NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.39209069
101E2F1_20622854_ChIP-Seq_HELA_Human1.38219117
102CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.34112389
103* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.33981038
104PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.32592158
105OCT4_18692474_ChIP-Seq_MEFs_Mouse1.31937416
106ZFX_18555785_ChIP-Seq_MESCs_Mouse1.30838142
107DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.30609754
108BRD4_27068464_Chip-Seq_AML-cells_Mouse1.30379886
109* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.30035711
110NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.29707069
111SOX2_18692474_ChIP-Seq_MEFs_Mouse1.29351577
112CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29260147
113GATA1_19941827_ChIP-Seq_MEL_Mouse1.29245023
114GATA1_22383799_ChIP-Seq_G1ME_Mouse1.28902319
115KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.28750129
116PPARA_22158963_ChIP-Seq_LIVER_Mouse1.28561173
117* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.27880501
118SPI1_23127762_ChIP-Seq_K562_Human1.27665381
119GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.27640919
120ESR2_21235772_ChIP-Seq_MCF-7_Human1.26384271
121* CTCF_26484167_Chip-Seq_Bcells_Mouse1.25782133
122SRF_21415370_ChIP-Seq_HL-1_Mouse1.25606500
123CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24496920
124SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.24084048
125ERG_21242973_ChIP-ChIP_JURKAT_Human1.24046432
126NCOR1_26117541_ChIP-Seq_K562_Human1.22678276
127IRF8_27001747_Chip-Seq_BMDM_Mouse1.22412686
128KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.22228151
129SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.21834484
130SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.21147310
131NANOG_21062744_ChIP-ChIP_HESCs_Human1.20903578
132SPI1_23547873_ChIP-Seq_NB4_Human1.19486343
133CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19274913
134TCF3_18692474_ChIP-Seq_MESCs_Mouse1.18784685
135ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.17969987
136TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.17719291
137TP53_22127205_ChIP-Seq_IMR90_Human1.17662218
138PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17579397
139POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.17524072
140SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17376909
141SOX2_18555785_ChIP-Seq_MESCs_Mouse1.16997195
142UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.16882018
143CTCF_18555785_ChIP-Seq_MESCs_Mouse1.16841992
144EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.16815039
145PU.1_20513432_ChIP-Seq_Bcells_Mouse1.16574298
146* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.16350780
147RXR_22158963_ChIP-Seq_LIVER_Mouse1.15894962
148PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15597692
149RARB_24833708_ChIP-Seq_LIVER_Mouse1.15158687
150DNAJC2_21179169_ChIP-ChIP_NT2_Human1.13658592
151* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.13139035
152SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12722254
153* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.12561990
154KDM2B_26808549_Chip-Seq_K562_Human1.11570633
155CTCF_20526341_ChIP-Seq_ESCs_Human1.11548792
156SA1_27219007_Chip-Seq_Bcells_Human1.11389052
157SOX2_18692474_ChIP-Seq_MESCs_Mouse1.11279239
158* CTCF_21964334_Chip-Seq_Bcells_Human1.10842858
159MYC_22102868_ChIP-Seq_BL_Human1.10764256
160SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10177516
161GATA1_19941826_ChIP-Seq_K562_Human1.10177509
162NANOG_18692474_ChIP-Seq_MEFs_Mouse1.09971873
163* TFEB_21752829_ChIP-Seq_HELA_Human1.09628621
164BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09278626
165GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07016082
166CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.06801399
167CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06536280
168E2F1_21310950_ChIP-Seq_MCF-7_Human1.05388686
169KAP1_27257070_Chip-Seq_ESCs_Mouse1.02636134
170TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02387141
171CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.01576180
172FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.00797611
173YY1_22570637_ChIP-Seq_MALME-3M_Human1.00137801
174FOXP1_21924763_ChIP-Seq_HESCs_Human0.97046502
175EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.96469893
176TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.95889841
177ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94883592
178PHF8_20622854_ChIP-Seq_HELA_Human0.94838918
179NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.94612185
180ELF1_17652178_ChIP-ChIP_JURKAT_Human0.94415717
181SALL1_21062744_ChIP-ChIP_HESCs_Human0.93899438
182SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.93413901
183CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.93202731
184SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.92995230
185SRY_22984422_ChIP-ChIP_TESTIS_Rat0.92627079
186ELK1_22589737_ChIP-Seq_MCF10A_Human0.91442385

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.92780471
2MP0003111_abnormal_nucleus_morphology4.98287431
3MP0009840_abnormal_foam_cell4.34032403
4MP0004957_abnormal_blastocyst_morpholog4.32617356
5MP0003718_maternal_effect3.74044363
6MP0008260_abnormal_autophagy3.66534792
7MP0003077_abnormal_cell_cycle3.47952734
8MP0010094_abnormal_chromosome_stability3.21968573
9MP0003436_decreased_susceptibility_to3.03233773
10MP0003303_peritoneal_inflammation2.90262756
11MP0001730_embryonic_growth_arrest2.75399771
12MP0008932_abnormal_embryonic_tissue2.59215965
13MP0002653_abnormal_ependyma_morphology2.51444612
14MP0002254_reproductive_system_inflammat2.37815706
15MP0008058_abnormal_DNA_repair2.36950708
16MP0002148_abnormal_hypersensitivity_rea2.35278508
17MP0003123_paternal_imprinting2.33346814
18MP0003786_premature_aging2.30075977
19MP0006082_CNS_inflammation2.26838873
20MP0008057_abnormal_DNA_replication2.22076373
21MP0001672_abnormal_embryogenesis/_devel2.10903522
22MP0005380_embryogenesis_phenotype2.10903522
23MP0002419_abnormal_innate_immunity2.08468714
24MP0000350_abnormal_cell_proliferation2.07297092
25MP0005464_abnormal_platelet_physiology2.06662037
26MP0005377_hearing/vestibular/ear_phenot2.03776418
27MP0003878_abnormal_ear_physiology2.03776418
28MP0005167_abnormal_blood-brain_barrier1.97796200
29MP0003724_increased_susceptibility_to1.93081779
30MP0000343_altered_response_to1.91499093
31MP0005058_abnormal_lysosome_morphology1.89699574
32MP0003806_abnormal_nucleotide_metabolis1.89322100
33MP0008007_abnormal_cellular_replicative1.88458051
34MP0005025_abnormal_response_to1.84631315
35MP0001697_abnormal_embryo_size1.80369209
36MP0002080_prenatal_lethality1.79546507
37MP0003984_embryonic_growth_retardation1.78270788
38MP0004510_myositis1.76441944
39MP0005000_abnormal_immune_tolerance1.74603822
40MP0002139_abnormal_hepatobiliary_system1.74054050
41MP0001533_abnormal_skeleton_physiology1.73088751
42MP0003075_altered_response_to1.72789783
43MP0002088_abnormal_embryonic_growth/wei1.72615566
44MP0009785_altered_susceptibility_to1.71755414
45MP0001661_extended_life_span1.69608617
46MP0004858_abnormal_nervous_system1.69393076
47MP0003119_abnormal_digestive_system1.69097832
48MP0002085_abnormal_embryonic_tissue1.67894350
49MP0009764_decreased_sensitivity_to1.66365875
50MP0000685_abnormal_immune_system1.61245951
51MP0001835_abnormal_antigen_presentation1.60292559
52MP0002084_abnormal_developmental_patter1.56040851
53MP0005671_abnormal_response_to1.54689816
54MP0004947_skin_inflammation1.51536944
55MP0005387_immune_system_phenotype1.50156486
56MP0001790_abnormal_immune_system1.50156486
57MP0003329_amyloid_beta_deposits1.49522196
58MP0001542_abnormal_bone_strength1.48278729
59MP0002723_abnormal_immune_serum1.48037732
60MP0010030_abnormal_orbit_morphology1.47800865
61MP0008004_abnormal_stomach_pH1.47387969
62MP0002998_abnormal_bone_remodeling1.46739903
63MP0002452_abnormal_antigen_presenting1.46577558
64MP0002086_abnormal_extraembryonic_tissu1.44533846
65MP0000858_altered_metastatic_potential1.43112742
66MP0004133_heterotaxia1.42155357
67MP0006035_abnormal_mitochondrial_morpho1.41593025
68MP0003300_gastrointestinal_ulcer1.36117821
69MP0003221_abnormal_cardiomyocyte_apopto1.35742740
70MP0001819_abnormal_immune_cell1.34698451
71MP0002420_abnormal_adaptive_immunity1.34510696
72MP0000358_abnormal_cell_content/1.33221459
73MP0010307_abnormal_tumor_latency1.33203345
74MP0005451_abnormal_body_composition1.31823495
75MP0003315_abnormal_perineum_morphology1.30319014
76MP0000747_muscle_weakness1.30204108
77MP0004885_abnormal_endolymph1.27051880
78MP0003938_abnormal_ear_development1.25148531
79MP0001873_stomach_inflammation1.23476724
80MP0001845_abnormal_inflammatory_respons1.23357269
81MP0008469_abnormal_protein_level1.22544184
82MP0005360_urolithiasis1.22000971
83MP0001800_abnormal_humoral_immune1.21310501
84MP0002405_respiratory_system_inflammati1.20088577
85MP0005390_skeleton_phenotype1.14401252
86MP0000313_abnormal_cell_death1.14252849
87MP0010155_abnormal_intestine_physiology1.13944069
88MP0004381_abnormal_hair_follicle1.13792375
89MP0002132_abnormal_respiratory_system1.13650102
90MP0005395_other_phenotype1.12629915
91MP0005332_abnormal_amino_acid1.12446792
92MP0004019_abnormal_vitamin_homeostasis1.11667368
93MP0009333_abnormal_splenocyte_physiolog1.11625267
94MP0003567_abnormal_fetal_cardiomyocyte1.11540278
95MP0003453_abnormal_keratinocyte_physiol1.08997274
96MP0003763_abnormal_thymus_physiology1.08246737
97MP0001853_heart_inflammation1.07551752
98MP0003279_aneurysm1.06784428
99MP0002269_muscular_atrophy1.06115622
100MP0006054_spinal_hemorrhage1.04844684
101MP0005384_cellular_phenotype1.01651197
102MP0009672_abnormal_birth_weight1.00848739
103MP0000716_abnormal_immune_system1.00171190
104MP0004197_abnormal_fetal_growth/weight/0.99571181
105MP0000465_gastrointestinal_hemorrhage0.98605272
106MP0002877_abnormal_melanocyte_morpholog0.98566145
107MP0005365_abnormal_bile_salt0.98252640
108MP0000428_abnormal_craniofacial_morphol0.98052799
109MP0005621_abnormal_cell_physiology0.97693940
110MP0002111_abnormal_tail_morphology0.95495374
111MP0000750_abnormal_muscle_regeneration0.95352958
112MP0001145_abnormal_male_reproductive0.94687994
113MP0000681_abnormal_thyroid_gland0.94434916
114MP0003890_abnormal_embryonic-extraembry0.93263747
115MP0008438_abnormal_cutaneous_collagen0.89904781
116MP0008877_abnormal_DNA_methylation0.89686227
117MP0002429_abnormal_blood_cell0.89493670
118MP0001756_abnormal_urination0.88738126
119MP0002210_abnormal_sex_determination0.86121176
120MP0003795_abnormal_bone_structure0.83847732
121MP0002160_abnormal_reproductive_system0.83346257
122MP0003191_abnormal_cellular_cholesterol0.82932813
123MP0002398_abnormal_bone_marrow0.82159256
124MP0000537_abnormal_urethra_morphology0.81601159
125MP0001849_ear_inflammation0.81393809
126MP0003879_abnormal_hair_cell0.79636774
127MP0003172_abnormal_lysosome_physiology0.79597662
128MP0002722_abnormal_immune_system0.79159288
129MP0001764_abnormal_homeostasis0.78749784
130MP0005076_abnormal_cell_differentiation0.78746406
131MP0001293_anophthalmia0.78738037
132MP0000689_abnormal_spleen_morphology0.78382612
133MP0005166_decreased_susceptibility_to0.77932621
134MP0001663_abnormal_digestive_system0.76977921
135MP0005595_abnormal_vascular_smooth0.76849598
136MP0002933_joint_inflammation0.76601648
137MP0002127_abnormal_cardiovascular_syste0.75579534
138MP0005410_abnormal_fertilization0.75413141
139MP0005310_abnormal_salivary_gland0.74809644
140MP0003828_pulmonary_edema0.74757439
141MP0005319_abnormal_enzyme/_coenzyme0.74654184
142MP0003705_abnormal_hypodermis_morpholog0.74032559
143MP0003186_abnormal_redox_activity0.74004929
144MP0009703_decreased_birth_body0.73487988
145MP0000015_abnormal_ear_pigmentation0.73451699
146MP0009278_abnormal_bone_marrow0.73357867
147MP0000490_abnormal_crypts_of0.73056484
148MP0003448_altered_tumor_morphology0.72946649
149MP0005647_abnormal_sex_gland0.72899601
150MP0004233_abnormal_muscle_weight0.72606162
151MP0004264_abnormal_extraembryonic_tissu0.71139010
152MP0005165_increased_susceptibility_to0.69967872
153MP0003941_abnormal_skin_development0.69528969
154MP0003183_abnormal_peptide_metabolism0.68346576
155MP0003646_muscle_fatigue0.68103738
156MP0003632_abnormal_nervous_system0.67880453
157MP0000653_abnormal_sex_gland0.67795351
158MP0002138_abnormal_hepatobiliary_system0.67655069
159MP0003937_abnormal_limbs/digits/tail_de0.67421712
160MP0000609_abnormal_liver_physiology0.67366212
161MP0003936_abnormal_reproductive_system0.66823898
162MP0005397_hematopoietic_system_phenotyp0.66792615
163MP0001545_abnormal_hematopoietic_system0.66792615
164MP0001929_abnormal_gametogenesis0.66165754
165MP0002019_abnormal_tumor_incidence0.66132154
166MP0010368_abnormal_lymphatic_system0.65827447
167MP0002092_abnormal_eye_morphology0.60634265
168MP0004084_abnormal_cardiac_muscle0.60135026
169MP0003861_abnormal_nervous_system0.59352093
170MP0006036_abnormal_mitochondrial_physio0.59061263
171MP0003136_yellow_coat_color0.58723849
172MP0003699_abnormal_female_reproductive0.58051906
173MP0005075_abnormal_melanosome_morpholog0.57510370
174MP0003283_abnormal_digestive_organ0.56282848
175MP0002161_abnormal_fertility/fecundity0.54299720
176MP0000604_amyloidosis0.53163532
177MP0002796_impaired_skin_barrier0.52034773
178MP0003656_abnormal_erythrocyte_physiolo0.51693559
179MP0003634_abnormal_glial_cell0.51483339
180MP0000627_abnormal_mammary_gland0.51245808

Predicted human phenotypes

RankGene SetZ-score
1Increased cerebral lipofuscin (HP:0011813)6.12960972
2Increased neuronal autofluorescent lipopigment (HP:0002074)5.72759160
3Breast hypoplasia (HP:0003187)5.49568118
4Cerebral hypomyelination (HP:0006808)5.19800669
5Dysostosis multiplex (HP:0000943)5.10305717
6Vacuolated lymphocytes (HP:0001922)4.98792782
7Birth length less than 3rd percentile (HP:0003561)4.89263073
8Carpal bone hypoplasia (HP:0001498)4.47394045
9Abnormality of mucopolysaccharide metabolism (HP:0011020)4.33839814
10Abnormality of polysaccharide metabolism (HP:0011012)4.33839814
11Abnormality of glycosaminoglycan metabolism (HP:0004371)4.33839814
12Rough bone trabeculation (HP:0100670)4.22515157
13Hyperglycinemia (HP:0002154)4.19266017
14Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)4.03261012
15Loss of speech (HP:0002371)3.87117299
16Mucopolysacchariduria (HP:0008155)3.86961961
17Urinary glycosaminoglycan excretion (HP:0003541)3.86961961
18Abnormality of the umbilical cord (HP:0010881)3.67963870
19Abnormality of the distal phalanges of the toes (HP:0010182)3.65538004
20Increased serum ferritin (HP:0003281)3.64009049
21Absent radius (HP:0003974)3.52432862
22Hyperglycinuria (HP:0003108)3.50702975
23Ureteral duplication (HP:0000073)3.50199821
24Patellar aplasia (HP:0006443)3.49497370
25Impulsivity (HP:0100710)3.49392319
26Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.44405442
27Aplasia/Hypoplasia of the patella (HP:0006498)3.43829710
28J-shaped sella turcica (HP:0002680)3.40354354
29Abnormality of macrophages (HP:0004311)3.38645878
30Aplasia involving forearm bones (HP:0009822)3.33639031
31Absent forearm bone (HP:0003953)3.33639031
32Gout (HP:0001997)3.29132575
33Petechiae (HP:0000967)3.27144082
34Systemic lupus erythematosus (HP:0002725)3.17078207
35Abnormality of the labia minora (HP:0012880)3.14770192
36Premature ovarian failure (HP:0008209)3.07802818
37Abnormality of iron homeostasis (HP:0011031)3.07686335
38Thoracic kyphosis (HP:0002942)3.07083470
39Abnormality of glycine metabolism (HP:0010895)3.05517946
40Abnormality of serine family amino acid metabolism (HP:0010894)3.05517946
41Abnormal trabecular bone morphology (HP:0100671)3.05149800
42Progressive muscle weakness (HP:0003323)3.03299147
43Megaloblastic anemia (HP:0001889)3.03083019
44Degeneration of anterior horn cells (HP:0002398)2.96094000
45Abnormality of the anterior horn cell (HP:0006802)2.96094000
46CNS hypomyelination (HP:0003429)2.89703047
47Abnormality of transition element cation homeostasis (HP:0011030)2.89628812
48Purpura (HP:0000979)2.86652694
49Premature rupture of membranes (HP:0001788)2.81520641
50Multiple enchondromatosis (HP:0005701)2.79567236
51Stomatitis (HP:0010280)2.78406634
52Atrophy/Degeneration involving motor neurons (HP:0007373)2.76200374
53Personality changes (HP:0000751)2.68845468
54Vertebral compression fractures (HP:0002953)2.68401894
55Delusions (HP:0000746)2.64736571
56Aplasia/Hypoplasia involving the musculature (HP:0001460)2.64421006
57Death in infancy (HP:0001522)2.61938489
58Abnormality of the thoracic spine (HP:0100711)2.61178440
59Eczematoid dermatitis (HP:0000976)2.57133912
60Axonal loss (HP:0003447)2.57126579
61Aplasia/hypoplasia of the humerus (HP:0006507)2.56193747
62Nuclear cataract (HP:0100018)2.54234728
63Secondary amenorrhea (HP:0000869)2.53820912
64Spinal muscular atrophy (HP:0007269)2.52342587
65Trismus (HP:0000211)2.50452531
66Ependymoma (HP:0002888)2.49911351
67Split foot (HP:0001839)2.44945803
68Autoimmune thrombocytopenia (HP:0001973)2.44034104
69Microretrognathia (HP:0000308)2.43603876
70Hepatosplenomegaly (HP:0001433)2.43323444
71Breast aplasia (HP:0100783)2.42173184
72Ankle contracture (HP:0006466)2.42053866
73Tetraplegia (HP:0002445)2.37990268
74Hypoplasia of the capital femoral epiphysis (HP:0003090)2.37611826
75Dysautonomia (HP:0002459)2.36384286
76Prolonged neonatal jaundice (HP:0006579)2.35453711
77Absent thumb (HP:0009777)2.30889487
78Postnatal microcephaly (HP:0005484)2.29664175
79Joint stiffness (HP:0001387)2.29643691
80Oral leukoplakia (HP:0002745)2.28756310
81Progressive neurologic deterioration (HP:0002344)2.28713719
82Sparse eyelashes (HP:0000653)2.28183460
83Entropion (HP:0000621)2.27370556
84Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.25373795
85Cervical subluxation (HP:0003308)2.25092111
86CNS demyelination (HP:0007305)2.24978657
87Abnormality of liposaccharide metabolism (HP:0010968)2.24129760
88Abnormality of glycosphingolipid metabolism (HP:0004343)2.24129760
89Abnormality of glycolipid metabolism (HP:0010969)2.24129760
90Abnormal neuron morphology (HP:0012757)2.24049518
91Abnormality of the motor neurons (HP:0002450)2.24049518
92Aplasia/Hypoplasia of the breasts (HP:0010311)2.22620244
93Prolonged bleeding time (HP:0003010)2.22564799
94Recurrent abscess formation (HP:0002722)2.21861616
95Myositis (HP:0100614)2.20327771
96Abnormal umbilical cord blood vessels (HP:0011403)2.19346081
97Single umbilical artery (HP:0001195)2.19346081
98Abnormality of the fetal cardiovascular system (HP:0010948)2.19346081
99Retinal atrophy (HP:0001105)2.19077429
100Sparse lateral eyebrow (HP:0005338)2.18942872
101Elevated erythrocyte sedimentation rate (HP:0003565)2.17953495
102Patent foramen ovale (HP:0001655)2.17499659
103Global brain atrophy (HP:0002283)2.17022458
104Recurrent bacterial skin infections (HP:0005406)2.16492504
105Short clavicles (HP:0000894)2.15853284
106Abnormality of serum amino acid levels (HP:0003112)2.14000358
107Amyotrophic lateral sclerosis (HP:0007354)2.13625684
108Absent hand (HP:0004050)2.12237731
109Horseshoe kidney (HP:0000085)2.11935955
110Xanthomatosis (HP:0000991)2.11916824
111Mesangial abnormality (HP:0001966)2.11736311
112Selective tooth agenesis (HP:0001592)2.10936304
113Reticulocytosis (HP:0001923)2.10887238
114Mutism (HP:0002300)2.08108440
115Stridor (HP:0010307)2.07758792
116Diminished motivation (HP:0000745)2.07451960
117Oligodactyly (HP:0012165)2.07131425
118Abnormalities of placenta or umbilical cord (HP:0001194)2.06804124
119Mediastinal lymphadenopathy (HP:0100721)2.05127368
120Obstructive lung disease (HP:0006536)2.04406913
121Chronic obstructive pulmonary disease (HP:0006510)2.04406913
122Bone marrow hypocellularity (HP:0005528)2.04385835
123Short humerus (HP:0005792)2.01868220
124Restlessness (HP:0000711)2.00828717
125Cardiomegaly (HP:0001640)2.00808398
126Achilles tendon contracture (HP:0001771)1.99865252
127Abnormality of lateral ventricle (HP:0030047)1.98524186
128Neurofibrillary tangles (HP:0002185)1.98353905
129Meckel diverticulum (HP:0002245)1.98313115
130Pustule (HP:0200039)1.97636753
131Clumsiness (HP:0002312)1.96082261
132Myocardial infarction (HP:0001658)1.95567034
133Abnormality of the ileum (HP:0001549)1.93039251
134Glossoptosis (HP:0000162)1.92566424
135Hemorrhage of the eye (HP:0011885)1.91595324
136Distal upper limb amyotrophy (HP:0007149)1.91410930
137Upper limb amyotrophy (HP:0009129)1.91410930
138Irregular epiphyses (HP:0010582)1.91032194
139Anal stenosis (HP:0002025)1.88023037
140Orchitis (HP:0100796)1.87792555
141Neuronal loss in central nervous system (HP:0002529)1.87719601
142Diaphragmatic weakness (HP:0009113)1.87364651
143Abnormality of the Achilles tendon (HP:0005109)1.87138056
144Neoplasm of the pancreas (HP:0002894)1.86967028
145Aplasia/Hypoplasia of the sacrum (HP:0008517)1.86750179
146Nonimmune hydrops fetalis (HP:0001790)1.86166350
147Apathy (HP:0000741)1.85342088
148Emotional lability (HP:0000712)1.85276443
149Aplasia/Hypoplasia of the clavicles (HP:0006710)1.85266008
150Shawl scrotum (HP:0000049)1.84047648
151Adactyly (HP:0009776)1.83873562
152Hyperacusis (HP:0010780)1.83614843
153Amyloidosis (HP:0011034)1.82975251
154Atrioventricular block (HP:0001678)1.82840688
155Oligodactyly (hands) (HP:0001180)1.82034244
156Spastic paraparesis (HP:0002313)1.81224085
157Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.79647943
158Absent epiphyses (HP:0010577)1.79647943
159Stillbirth (HP:0003826)1.79219411
160Hematochezia (HP:0002573)1.78196314
161Epistaxis (HP:0000421)1.78148635
162Testicular atrophy (HP:0000029)1.77882733
163Premature graying of hair (HP:0002216)1.75767902
164Dementia (HP:0000726)1.75488731
165Macrocytic anemia (HP:0001972)1.75430705
166Bulbar palsy (HP:0001283)1.75008361
167Disinhibition (HP:0000734)1.74558249
168Shoulder girdle muscle weakness (HP:0003547)1.74422154
169Aplasia/Hypoplasia of the uvula (HP:0010293)1.73996951
170Asymmetric septal hypertrophy (HP:0001670)1.73866863
171Cerebral aneurysm (HP:0004944)1.70321520
172Recurrent fungal infections (HP:0002841)1.66316668
173Upper motor neuron abnormality (HP:0002127)1.65969077
174Deformed sella turcica (HP:0002681)1.65861134
175Hypertriglyceridemia (HP:0002155)1.64643190
176Easy fatigability (HP:0003388)1.62034007
177Thin bony cortex (HP:0002753)1.60992559
178Polycythemia (HP:0001901)1.60023186
179Increased IgM level (HP:0003496)1.59814518
180Ragged-red muscle fibers (HP:0003200)1.58886381
181Glomerulonephritis (HP:0000099)1.57844384
182Impaired platelet aggregation (HP:0003540)1.54644297
183Abnormal platelet function (HP:0011869)1.54644297
184Abnormality of the vasculature of the conjunctiva (HP:0008054)1.53193136
185Spinal rigidity (HP:0003306)1.53173470
186Elevated alkaline phosphatase (HP:0003155)1.52630869
187Opisthotonus (HP:0002179)1.52185362
188Premature skin wrinkling (HP:0100678)1.51545722
189Paraparesis (HP:0002385)1.51373562
190Abnormal enzyme/coenzyme activity (HP:0012379)1.51156235
191Long toe (HP:0010511)1.51057667
192Flat capital femoral epiphysis (HP:0003370)1.50916017
193Hypertensive crisis (HP:0100735)1.50844189

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB17.07571623
2WEE14.02088384
3AKT33.83617017
4EPHA23.58469873
5TSSK63.45084469
6ERN13.38886595
7NEK22.88594873
8TRIB32.72731673
9SIK12.53535900
10ARAF2.46088795
11NEK12.45568861
12PLK42.32033341
13STK162.20017730
14TTK2.19519804
15EIF2AK12.19168082
16SMG12.01328449
17MAP4K11.92989042
18BRAF1.91665551
19TESK11.87983280
20TIE11.83208098
21LATS21.82766046
22PLK11.81994627
23RIPK41.81736453
24PNCK1.79327210
25MAP2K31.78692858
26MARK31.74825423
27TBK11.74608950
28ICK1.69915030
29TESK21.67113660
30SRPK11.65605325
31DYRK31.59639130
32PLK31.56722799
33NME21.50165224
34PIM21.49968343
35MATK1.46864141
36MAPKAPK31.42363550
37STK38L1.39645184
38ZAP701.39275589
39SIK31.33642542
40CDC42BPA1.31474169
41CHEK21.29297002
42IRAK41.27894186
43IKBKB1.22106219
44EPHB11.21948998
45PAK41.21430220
46EEF2K1.20935816
47MAP3K11.20616387
48KDR1.18941309
49SIK21.18845078
50AURKA1.17824802
51TGFBR21.15833102
52CDK71.14870346
53BRSK11.13726123
54BRSK21.12597251
55PRKCI1.11895026
56CDC71.11430885
57ZAK1.10597388
58TAOK11.08026349
59EIF2AK31.02580708
60MAP3K81.01298689
61MAP3K91.00931753
62PINK10.99235933
63GRK70.99106509
64ALK0.98826016
65MAP3K110.98737317
66ADRBK20.98037951
67BLK0.97422645
68AURKB0.97357805
69JAK30.95686046
70CCNB10.95460726
71BTK0.93363070
72TLK10.92152968
73BCKDK0.90278798
74ACVR1B0.90240708
75TNK20.89975721
76PAK10.89847731
77PDK20.89362033
78PRKD20.88065330
79CHEK10.85262486
80RPS6KA20.84549003
81PDK40.84103447
82PDK30.84103447
83TYK20.84002460
84BMX0.80144913
85CDK40.79786242
86RPS6KL10.79711921
87RPS6KC10.79711921
88VRK20.79238662
89CDK120.76571334
90MAP3K140.76057328
91RPS6KA60.75440103
92LIMK10.75105741
93PDPK10.75000689
94IRAK20.74963090
95PKN20.74629664
96CSK0.74374807
97HIPK20.73894946
98TTN0.73350498
99CSNK1G30.73237696
100FES0.71716950
101CDK20.69484959
102IKBKE0.69475841
103IRAK30.69091844
104TXK0.68932277
105RIPK10.67150066
106DYRK20.65874200
107NME10.65695714
108RPS6KA40.65196574
109ATR0.63903163
110TAOK20.63578791
111MOS0.63508901
112MARK20.62947661
113PRKG20.62131155
114CSNK1E0.61020599
115STK380.60351160
116MAP2K20.59422725
117MTOR0.59001212
118KIT0.58934372
119CHUK0.58642596
120HCK0.58506116
121AKT20.58186567
122PRPF4B0.57975098
123RPS6KB20.57943423
124STK30.56131998
125VRK10.56076712
126FGR0.54883271
127MAP3K130.51470892
128SYK0.51076624
129RAF10.51002623
130IRAK10.49855786
131CSNK2A20.49819456
132MAP2K60.49618105
133FGFR40.46217772
134MKNK10.46047392
135PIM10.45732159
136CDK10.45456146
137MAP3K70.45433169
138GRK60.45370103
139CSF1R0.45311210
140TAOK30.44525187
141STK100.43832797
142PAK60.43594561
143MAP3K30.42372734
144LYN0.41545249
145MKNK20.41301079
146MAPKAPK20.41004647
147CSNK2A10.40706658
148MARK10.40635960
149CSNK1A1L0.40273250
150MAP3K50.39966235
151DYRK1B0.39304422
152LCK0.38934684
153CSNK1G10.38152872
154CSNK1G20.37530585
155DDR20.35544052
156RPS6KA50.33188475
157ABL20.32429785
158PRKCG0.30022669
159PRKAA10.29243063
160DAPK30.28628193
161TYRO30.26945948
162ATM0.26750694
163CSNK1A10.22981242
164MAPK110.22666841
165CDK11A0.22495418
166MAPK100.21325247
167DAPK10.21214141
168CDK140.21063078
169CDK150.20212896
170STK40.19552759

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.41060288
2Glycosaminoglycan degradation_Homo sapiens_hsa005314.51983849
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.34399638
4RNA polymerase_Homo sapiens_hsa030204.20467391
5Proteasome_Homo sapiens_hsa030503.76611516
6RNA transport_Homo sapiens_hsa030133.15508307
7Folate biosynthesis_Homo sapiens_hsa007903.02488920
8DNA replication_Homo sapiens_hsa030302.80648546
9Spliceosome_Homo sapiens_hsa030402.64443677
10Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.52085033
11Mismatch repair_Homo sapiens_hsa034302.31767230
12Pyrimidine metabolism_Homo sapiens_hsa002402.31323563
13Regulation of autophagy_Homo sapiens_hsa041402.26659162
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.23578093
15Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.22158332
16Base excision repair_Homo sapiens_hsa034102.19656892
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.10024749
18Cell cycle_Homo sapiens_hsa041102.04075338
19Osteoclast differentiation_Homo sapiens_hsa043801.90522480
20Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.87790223
21Ribosome_Homo sapiens_hsa030101.85903927
22Rheumatoid arthritis_Homo sapiens_hsa053231.84092438
23Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.83889990
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.83118114
25Nucleotide excision repair_Homo sapiens_hsa034201.79679568
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.79120637
27Pentose phosphate pathway_Homo sapiens_hsa000301.76848455
28Biosynthesis of amino acids_Homo sapiens_hsa012301.75097447
29Homologous recombination_Homo sapiens_hsa034401.72025005
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.67171390
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.67130070
32Staphylococcus aureus infection_Homo sapiens_hsa051501.64677517
33NF-kappa B signaling pathway_Homo sapiens_hsa040641.64531697
34Glycerophospholipid metabolism_Homo sapiens_hsa005641.64004881
35Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.55822656
36One carbon pool by folate_Homo sapiens_hsa006701.54654944
37Malaria_Homo sapiens_hsa051441.54554445
38Tuberculosis_Homo sapiens_hsa051521.52725561
39TNF signaling pathway_Homo sapiens_hsa046681.50569898
40Leishmaniasis_Homo sapiens_hsa051401.49267175
41Acute myeloid leukemia_Homo sapiens_hsa052211.48156850
42Fructose and mannose metabolism_Homo sapiens_hsa000511.48137567
43Basal transcription factors_Homo sapiens_hsa030221.47752727
44Pertussis_Homo sapiens_hsa051331.47595503
45Phagosome_Homo sapiens_hsa041451.46965740
46Purine metabolism_Homo sapiens_hsa002301.44091513
47p53 signaling pathway_Homo sapiens_hsa041151.43732138
48Vitamin digestion and absorption_Homo sapiens_hsa049771.42514758
49Sulfur relay system_Homo sapiens_hsa041221.33230231
50Cyanoamino acid metabolism_Homo sapiens_hsa004601.32337963
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.31056149
52Fanconi anemia pathway_Homo sapiens_hsa034601.30599676
53RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.28167343
54Allograft rejection_Homo sapiens_hsa053301.27894020
55Drug metabolism - other enzymes_Homo sapiens_hsa009831.19931667
56Oocyte meiosis_Homo sapiens_hsa041141.19684342
57Legionellosis_Homo sapiens_hsa051341.13261847
58mRNA surveillance pathway_Homo sapiens_hsa030151.11981378
59Salmonella infection_Homo sapiens_hsa051321.09309031
60Epstein-Barr virus infection_Homo sapiens_hsa051691.06618238
61Intestinal immune network for IgA production_Homo sapiens_hsa046721.06163280
62Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.05802004
63Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.05116142
64Carbon metabolism_Homo sapiens_hsa012001.01745865
65Primary immunodeficiency_Homo sapiens_hsa053401.00867650
66Toxoplasmosis_Homo sapiens_hsa051451.00812768
67Graft-versus-host disease_Homo sapiens_hsa053321.00772255
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.98885386
69Hematopoietic cell lineage_Homo sapiens_hsa046400.96753478
70NOD-like receptor signaling pathway_Homo sapiens_hsa046210.96712045
71Lysosome_Homo sapiens_hsa041420.96326041
72Asthma_Homo sapiens_hsa053100.94462326
73B cell receptor signaling pathway_Homo sapiens_hsa046620.93117393
74Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.91792594
75VEGF signaling pathway_Homo sapiens_hsa043700.90937280
76N-Glycan biosynthesis_Homo sapiens_hsa005100.86418048
77Autoimmune thyroid disease_Homo sapiens_hsa053200.85638917
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.84804876
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.84033673
80RNA degradation_Homo sapiens_hsa030180.83500420
81Sulfur metabolism_Homo sapiens_hsa009200.82392852
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.82385257
83Herpes simplex infection_Homo sapiens_hsa051680.82000606
84Shigellosis_Homo sapiens_hsa051310.81942261
85Influenza A_Homo sapiens_hsa051640.79345605
86Hepatitis C_Homo sapiens_hsa051600.79104134
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.76799874
88Hepatitis B_Homo sapiens_hsa051610.74828727
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.74819902
90Arginine and proline metabolism_Homo sapiens_hsa003300.74630962
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74105779
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72403767
93mTOR signaling pathway_Homo sapiens_hsa041500.72389492
94Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.71665824
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70519984
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.69602222
97Glutathione metabolism_Homo sapiens_hsa004800.67993905
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.66393991
99African trypanosomiasis_Homo sapiens_hsa051430.65126348
100Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.62683349
101T cell receptor signaling pathway_Homo sapiens_hsa046600.62365682
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60524820
103Selenocompound metabolism_Homo sapiens_hsa004500.58940477
104Collecting duct acid secretion_Homo sapiens_hsa049660.57793368
105Complement and coagulation cascades_Homo sapiens_hsa046100.56550591
106Metabolic pathways_Homo sapiens_hsa011000.55968375
107Hippo signaling pathway_Homo sapiens_hsa043900.54969642
108Chemokine signaling pathway_Homo sapiens_hsa040620.54298097
109Amoebiasis_Homo sapiens_hsa051460.53351295
110Viral myocarditis_Homo sapiens_hsa054160.53240317
111Platelet activation_Homo sapiens_hsa046110.50891256
112Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49657442
113Hedgehog signaling pathway_Homo sapiens_hsa043400.48893809
114PPAR signaling pathway_Homo sapiens_hsa033200.47978221
115Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47825190
116Other glycan degradation_Homo sapiens_hsa005110.47633738
117Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.46547289
118Jak-STAT signaling pathway_Homo sapiens_hsa046300.46336061
119Type I diabetes mellitus_Homo sapiens_hsa049400.46169550
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.46062718
121Insulin resistance_Homo sapiens_hsa049310.44968348
122Measles_Homo sapiens_hsa051620.44221178
123Neurotrophin signaling pathway_Homo sapiens_hsa047220.41758247
124Steroid biosynthesis_Homo sapiens_hsa001000.39330547
125Sphingolipid metabolism_Homo sapiens_hsa006000.39194146
126Chronic myeloid leukemia_Homo sapiens_hsa052200.38269182
127Galactose metabolism_Homo sapiens_hsa000520.37261196
128ABC transporters_Homo sapiens_hsa020100.35552509
129Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35088496
130Circadian rhythm_Homo sapiens_hsa047100.34950787
131Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33611229
132Glycerolipid metabolism_Homo sapiens_hsa005610.33175474
133Butanoate metabolism_Homo sapiens_hsa006500.32451824
134Non-small cell lung cancer_Homo sapiens_hsa052230.31024160
135Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29363759
136Viral carcinogenesis_Homo sapiens_hsa052030.27936655
137Notch signaling pathway_Homo sapiens_hsa043300.27740465
138Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.27157982
139Renin-angiotensin system_Homo sapiens_hsa046140.25443520
140Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.22114794
141Mineral absorption_Homo sapiens_hsa049780.20300837
142Prion diseases_Homo sapiens_hsa050200.19470131
143Tight junction_Homo sapiens_hsa045300.19172859
144Basal cell carcinoma_Homo sapiens_hsa052170.18239384
145Inositol phosphate metabolism_Homo sapiens_hsa005620.16886953
146Arachidonic acid metabolism_Homo sapiens_hsa005900.16216782
147Huntingtons disease_Homo sapiens_hsa050160.15808908
148Antigen processing and presentation_Homo sapiens_hsa046120.15754659
149Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.15650879
150HIF-1 signaling pathway_Homo sapiens_hsa040660.13665509
151Linoleic acid metabolism_Homo sapiens_hsa005910.12808950
152HTLV-I infection_Homo sapiens_hsa051660.11614083
153Synaptic vesicle cycle_Homo sapiens_hsa047210.11210904
154Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.11086648
155Non-homologous end-joining_Homo sapiens_hsa034500.10548058
156Bladder cancer_Homo sapiens_hsa052190.10435089
157Thyroid cancer_Homo sapiens_hsa052160.10399908
158Fatty acid elongation_Homo sapiens_hsa000620.10371085
159Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.10117810
160Renal cell carcinoma_Homo sapiens_hsa052110.09279035
161AMPK signaling pathway_Homo sapiens_hsa041520.07779489
162Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.05772580
163Endocytosis_Homo sapiens_hsa041440.05633434
164Apoptosis_Homo sapiens_hsa042100.05415934
165alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.04042838
166Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.03652410
167Ether lipid metabolism_Homo sapiens_hsa005650.02700326
168MicroRNAs in cancer_Homo sapiens_hsa052060.01557005
169Vibrio cholerae infection_Homo sapiens_hsa051100.01395758

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