SPINT4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of chronic inflammatory response (GO:0002676)9.22326802
2single fertilization (GO:0007338)8.79226950
3heterotypic cell-cell adhesion (GO:0034113)8.59985379
4tryptophan catabolic process (GO:0006569)8.59580306
5indole-containing compound catabolic process (GO:0042436)8.59580306
6indolalkylamine catabolic process (GO:0046218)8.59580306
7positive regulation of type 2 immune response (GO:0002830)7.64712851
8negative regulation of interleukin-10 production (GO:0032693)7.46985481
9tryptophan metabolic process (GO:0006568)7.38614866
10aromatic amino acid family catabolic process (GO:0009074)5.87703328
11fertilization (GO:0009566)5.80338220
12amine catabolic process (GO:0009310)5.55549044
13cellular biogenic amine catabolic process (GO:0042402)5.55549044
14indolalkylamine metabolic process (GO:0006586)5.41083731
15negative regulation of interleukin-8 production (GO:0032717)5.35635956
16benzene-containing compound metabolic process (GO:0042537)4.85957552
17digestion (GO:0007586)4.72335462
18epithelial cell morphogenesis (GO:0003382)4.44326831
19negative regulation of T cell apoptotic process (GO:0070233)4.37580812
20positive regulation of cell-cell adhesion (GO:0022409)4.31834976
21aromatic amino acid family metabolic process (GO:0009072)4.29833006
22transepithelial transport (GO:0070633)4.11157008
23regulation of clathrin-mediated endocytosis (GO:2000369)3.98754755
24regulation of type 2 immune response (GO:0002828)3.96063248
25indole-containing compound metabolic process (GO:0042430)3.85999153
26sulfur amino acid catabolic process (GO:0000098)3.79660460
27reverse cholesterol transport (GO:0043691)3.66224310
28defense response to bacterium (GO:0042742)3.62217876
29N-acetylneuraminate metabolic process (GO:0006054)3.56830590
30* negative regulation of endopeptidase activity (GO:0010951)3.56290111
31* negative regulation of peptidase activity (GO:0010466)3.39204149
32negative regulation of protein autophosphorylation (GO:0031953)3.38986811
33phospholipid homeostasis (GO:0055091)3.28309604
34negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.27350515
35response to bacterium (GO:0009617)3.14887771
36fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.11564321
37alpha-linolenic acid metabolic process (GO:0036109)3.08311771
38regulation of lipoprotein metabolic process (GO:0050746)3.04418431
39regulation of macrophage activation (GO:0043030)3.03006520
40seminiferous tubule development (GO:0072520)25.5079370
41glial cell proliferation (GO:0014009)2.81965766
42complement activation, alternative pathway (GO:0006957)2.81604382
43pyrimidine ribonucleoside catabolic process (GO:0046133)2.80298360
44hormone catabolic process (GO:0042447)2.79899040
45regulation of activated T cell proliferation (GO:0046006)2.79163156
46O-glycan processing (GO:0016266)2.76235459
47cysteine metabolic process (GO:0006534)2.74391891
48negative regulation of glycogen biosynthetic process (GO:0045719)2.72662157
49regulation of beta-amyloid formation (GO:1902003)2.72036952
50sialylation (GO:0097503)2.66076439
51negative regulation of lymphocyte apoptotic process (GO:0070229)2.64150250
52columnar/cuboidal epithelial cell development (GO:0002066)2.62671161
53high-density lipoprotein particle remodeling (GO:0034375)2.61789729
54negative regulation of receptor-mediated endocytosis (GO:0048261)2.60649592
55low-density lipoprotein particle clearance (GO:0034383)2.60513748
56positive regulation of interleukin-12 production (GO:0032735)2.58686737
57positive regulation of cellular amide metabolic process (GO:0034250)2.52949026
58L-serine transport (GO:0015825)2.48516706
59regulation of amyloid precursor protein catabolic process (GO:1902991)2.46185577
60negative regulation of glycogen metabolic process (GO:0070874)2.44392349
61lipid catabolic process (GO:0016042)2.37562350
62valine metabolic process (GO:0006573)2.37424817
63response to misfolded protein (GO:0051788)2.33711396
64alpha-amino acid catabolic process (GO:1901606)2.33391668
65triglyceride catabolic process (GO:0019433)2.31516809
66cellular amino acid catabolic process (GO:0009063)2.28382095
67* negative regulation of proteolysis (GO:0045861)2.27301989
68acylglycerol catabolic process (GO:0046464)2.24169864
69neutral lipid catabolic process (GO:0046461)2.24169864
70negative regulation of interleukin-6 production (GO:0032715)2.22039090
71regulation of interleukin-10 production (GO:0032653)2.21009402
72* negative regulation of protein processing (GO:0010955)2.18922530
73* negative regulation of protein maturation (GO:1903318)2.18922530
74regulation of T cell apoptotic process (GO:0070232)2.18062255
75positive regulation of sterol transport (GO:0032373)2.17694584
76positive regulation of cholesterol transport (GO:0032376)2.17694584
77erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.16228261
78L-phenylalanine catabolic process (GO:0006559)2.16228261
79COPI coating of Golgi vesicle (GO:0048205)2.13474664
80Golgi transport vesicle coating (GO:0048200)2.13474664
81serine transport (GO:0032329)2.13081472
82negative regulation of T cell proliferation (GO:0042130)2.11493580
83protein-lipid complex remodeling (GO:0034368)2.11487335
84macromolecular complex remodeling (GO:0034367)2.11487335
85plasma lipoprotein particle remodeling (GO:0034369)2.11487335
86cellular response to epidermal growth factor stimulus (GO:0071364)2.09855263
87myelin maintenance (GO:0043217)2.08965354
88regulation of apoptotic cell clearance (GO:2000425)2.08804772
89glutamate metabolic process (GO:0006536)2.08393480
90regulation of lipoprotein particle clearance (GO:0010984)2.07980206
91regulation of reproductive process (GO:2000241)2.06246690
92* negative regulation of hydrolase activity (GO:0051346)2.04927050
93cellular modified amino acid catabolic process (GO:0042219)2.04721458
94myeloid cell homeostasis (GO:0002262)2.01335682
95regulation of T cell tolerance induction (GO:0002664)14.5525243
96production of molecular mediator involved in inflammatory response (GO:0002532)14.4945492
97positive regulation of tolerance induction (GO:0002645)12.4692919
98sperm capacitation (GO:0048240)11.4900307
99regulation of tolerance induction (GO:0002643)10.8466622
100kynurenine metabolic process (GO:0070189)10.5401762

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human4.81981460
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.49207538
3IKZF1_21737484_ChIP-ChIP_HCT116_Human4.15722268
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.37417598
5AR_21572438_ChIP-Seq_LNCaP_Human3.19520230
6CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.79945655
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.72085749
8ESR1_21235772_ChIP-Seq_MCF-7_Human2.71552085
9ZNF263_19887448_ChIP-Seq_K562_Human2.49887072
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.41844550
11RXR_22158963_ChIP-Seq_LIVER_Mouse2.41515567
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.38128370
13LXR_22158963_ChIP-Seq_LIVER_Mouse2.38124529
14DNAJC2_21179169_ChIP-ChIP_NT2_Human2.26808438
15SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse2.17271833
16ESR2_21235772_ChIP-Seq_MCF-7_Human2.10743453
17TRIM28_21343339_ChIP-Seq_HEK293_Human2.03591773
18CLOCK_20551151_ChIP-Seq_293T_Human2.01927480
19PPARA_22158963_ChIP-Seq_LIVER_Mouse1.97494141
20GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.90422212
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.85459054
22EGR1_23403033_ChIP-Seq_LIVER_Mouse1.83208086
23NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.73218243
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.68079473
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.64770521
26FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.62450467
27STAT1_17558387_ChIP-Seq_HELA_Human1.61043734
28CDX2_19796622_ChIP-Seq_MESCs_Mouse1.60289883
29RAD21_21589869_ChIP-Seq_MESCs_Mouse1.60212455
30SMAD4_21741376_ChIP-Seq_HESCs_Human1.59119278
31SOX2_22085726_ChIP-Seq_NPCs_Mouse1.56338712
32ESRRB_18555785_Chip-Seq_ESCs_Mouse1.51827247
33SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.48763679
34SUZ12_27294783_Chip-Seq_NPCs_Mouse1.48416769
35* GATA3_21867929_ChIP-Seq_TH1_Mouse1.47431128
36EZH2_18974828_ChIP-Seq_MESCs_Mouse1.46924072
37RNF2_18974828_ChIP-Seq_MESCs_Mouse1.46924072
38* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.44754104
39* SMAD1_18555785_Chip-Seq_ESCs_Mouse1.43979618
40TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.43266952
41ELF1_20517297_ChIP-Seq_JURKAT_Human1.42110223
42* TET1_21451524_ChIP-Seq_MESCs_Mouse1.41612196
43SMAD3_21741376_ChIP-Seq_HESCs_Human1.38242675
44SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.37753357
45GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.34230369
46P68_20966046_ChIP-Seq_HELA_Human1.30299849
47CTCF_18555785_Chip-Seq_ESCs_Mouse1.25306308
48* FLI1_21867929_ChIP-Seq_CD8_Mouse1.22305846
49JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.20885190
50PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.20610894
51* REST_19997604_ChIP-ChIP_NEURONS_Mouse1.19973446
52MYC_27129775_Chip-Seq_CORNEA_Mouse1.19829180
53BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human1.19781196
54VDR_24787735_ChIP-Seq_THP-1_Human1.19564242
55NFE2_27457419_Chip-Seq_LIVER_Mouse1.18824307
56RACK7_27058665_Chip-Seq_MCF-7_Human1.17509800
57SALL4_22934838_ChIP-ChIP_CD34+_Human1.16841433
58BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.13619152
59SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.12377944
60SOX9_24532713_ChIP-Seq_HFSC_Mouse1.10747172
61FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10116370
62SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.10108987
63BCL6_27268052_Chip-Seq_Bcells_Human1.06377010
64ELK4_26923725_Chip-Seq_MESODERM_Mouse1.05735057
65NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05342464
66TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04911770
67EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.01185302
68MTF2_20144788_ChIP-Seq_MESCs_Mouse1.00776501
69CBX2_27304074_Chip-Seq_ESCs_Mouse0.99475705
70* CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96305606
71DROSHA_22980978_ChIP-Seq_HELA_Human0.95686156
72REST_18959480_ChIP-ChIP_MESCs_Mouse0.95361517
73SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.95293272
74BCOR_27268052_Chip-Seq_Bcells_Human0.94756239
75KDM2B_26808549_Chip-Seq_REH_Human0.94303077
76LXR_22292898_ChIP-Seq_THP-1_Human0.94080576
77EZH2_27294783_Chip-Seq_NPCs_Mouse0.93666420
78SOX2_18555785_Chip-Seq_ESCs_Mouse0.93611606
79TP53_20018659_ChIP-ChIP_R1E_Mouse0.93554031
80SOX2_20726797_ChIP-Seq_SW620_Human0.93405310
81SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.92902435
82NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.92276663
83SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.92004692
84P300_27268052_Chip-Seq_Bcells_Human0.91357700
85ZNF217_24962896_ChIP-Seq_MCF-7_Human0.91266086
86RUNX1_27457419_Chip-Seq_LIVER_Mouse0.90658951
87BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90583031
88SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.90234076
89RAC3_21632823_ChIP-Seq_H3396_Human0.89621345
90EZH2_27304074_Chip-Seq_ESCs_Mouse0.89442902
91KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.88480857
92CSB_26484114_Chip-Seq_FIBROBLAST_Human0.88335125
93GATA1_19941826_ChIP-Seq_K562_Human0.87753922
94ERG_21242973_ChIP-ChIP_JURKAT_Human0.86985356
95OCT4_20526341_ChIP-Seq_ESCs_Human0.86353636
96* MYC_19915707_ChIP-ChIP_AK7_Human0.85995112
97KDM2B_26808549_Chip-Seq_K562_Human0.85766064
98NANOG_20526341_ChIP-Seq_ESCs_Human0.85266908
99PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.83447021
100TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.83315794

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation5.56489612
2MP0003195_calcinosis5.51664473
3MP0002254_reproductive_system_inflammat5.04981961
4MP0004043_abnormal_pH_regulation4.82298921
5MP0002139_abnormal_hepatobiliary_system4.51209062
6MP0010234_abnormal_vibrissa_follicle4.13456561
7MP0005058_abnormal_lysosome_morphology3.52954305
8MP0005410_abnormal_fertilization3.38298941
9MP0003329_amyloid_beta_deposits3.04781427
10MP0000003_abnormal_adipose_tissue2.30913907
11MP0005360_urolithiasis2.12861456
12MP0010329_abnormal_lipoprotein_level2.08472998
13MP0000604_amyloidosis2.06515540
14MP0003300_gastrointestinal_ulcer2.04489041
15MP0002168_other_aberrant_phenotype2.04056880
16MP0005365_abnormal_bile_salt1.75202004
17MP0001765_abnormal_ion_homeostasis1.72312584
18MP0004885_abnormal_endolymph1.68523773
19MP0003566_abnormal_cell_adhesion1.66384430
20MP0005375_adipose_tissue_phenotype1.62106640
21MP0001501_abnormal_sleep_pattern1.57824625
22MP0004130_abnormal_muscle_cell1.56746470
23MP0005085_abnormal_gallbladder_physiolo1.50249260
24MP0001853_heart_inflammation1.47219061
25MP0009643_abnormal_urine_homeostasis1.45021366
26MP0002837_dystrophic_cardiac_calcinosis1.43994621
27MP0001440_abnormal_grooming_behavior1.41625668
28MP0000534_abnormal_ureter_morphology1.36592876
29MP0001756_abnormal_urination1.34337992
30MP0003690_abnormal_glial_cell1.33656268
31MP0004185_abnormal_adipocyte_glucose1.27880531
32MP0004859_abnormal_synaptic_plasticity1.26812939
33MP0005332_abnormal_amino_acid1.26513829
34MP0003705_abnormal_hypodermis_morpholog1.26426884
35MP0009379_abnormal_foot_pigmentation1.22688775
36MP0002118_abnormal_lipid_homeostasis1.22430605
37MP0000537_abnormal_urethra_morphology1.20564533
38MP0008438_abnormal_cutaneous_collagen1.18270979
39MP0002089_abnormal_postnatal_growth/wei1.16634816
40MP0003879_abnormal_hair_cell1.14975514
41MP0004858_abnormal_nervous_system1.14718910
42MP0005636_abnormal_mineral_homeostasis1.12714488
43MP0005584_abnormal_enzyme/coenzyme_acti1.12405344
44MP0003191_abnormal_cellular_cholesterol1.11628569
45MP0005275_abnormal_skin_tensile1.10533293
46MP0005083_abnormal_biliary_tract1.06170053
47MP0002896_abnormal_bone_mineralization1.04292151
48MP0002796_impaired_skin_barrier1.03711288
49MP0002876_abnormal_thyroid_physiology1.03118738
50MP0009780_abnormal_chondrocyte_physiolo1.02943581
51MP0003806_abnormal_nucleotide_metabolis1.02839426
52MP0005666_abnormal_adipose_tissue0.99725946
53MP0003698_abnormal_male_reproductive0.95233077
54MP0004270_analgesia0.93700403
55MP0002909_abnormal_adrenal_gland0.90640930
56MP0003075_altered_response_to0.90621067
57MP0003252_abnormal_bile_duct0.90521772
58MP0003632_abnormal_nervous_system0.90356820
59MP0002136_abnormal_kidney_physiology0.88656384
60MP0000920_abnormal_myelination0.88594683
61MP0005670_abnormal_white_adipose0.86866857
62MP0008875_abnormal_xenobiotic_pharmacok0.86766372
63MP0000462_abnormal_digestive_system0.82768501
64MP0002933_joint_inflammation0.81001827
65MP0002733_abnormal_thermal_nociception0.79852750
66MP0000538_abnormal_urinary_bladder0.77077504
67MP0000609_abnormal_liver_physiology0.75079401
68MP0005395_other_phenotype0.71780980
69MP0002138_abnormal_hepatobiliary_system0.71720461
70MP0003631_nervous_system_phenotype0.69833118
71MP0005319_abnormal_enzyme/_coenzyme0.68797891
72MP0002653_abnormal_ependyma_morphology0.68655800
73MP0000747_muscle_weakness0.67460932
74MP0005334_abnormal_fat_pad0.67413570
75MP0004036_abnormal_muscle_relaxation0.66645911
76MP0001666_abnormal_nutrient_absorption0.66505915
77MP0003635_abnormal_synaptic_transmissio0.65483201
78MP0002735_abnormal_chemical_nociception0.65143414
79MP0003633_abnormal_nervous_system0.65069983
80MP0005535_abnormal_body_temperature0.64903150
81MP0004145_abnormal_muscle_electrophysio0.62194785
82MP0003634_abnormal_glial_cell0.61875904
83MP0001970_abnormal_pain_threshold0.60328417
84MP0009053_abnormal_anal_canal0.60135193
85MP0002272_abnormal_nervous_system0.60120249
86MP0002971_abnormal_brown_adipose0.59250663
87MP0000013_abnormal_adipose_tissue0.59201875
88MP0000249_abnormal_blood_vessel0.57545261
89MP0003123_paternal_imprinting0.56165586
90MP0002295_abnormal_pulmonary_circulatio0.55612258
91MP0010678_abnormal_skin_adnexa0.55338083
92MP0009384_cardiac_valve_regurgitation0.51665601
93MP0005166_decreased_susceptibility_to0.51430997
94MP0002161_abnormal_fertility/fecundity0.50206589
95MP0002078_abnormal_glucose_homeostasis0.49429211
96MP0003959_abnormal_lean_body0.48622074
97MP0004272_abnormal_basement_membrane0.47476729
98MP0009840_abnormal_foam_cell0.47072380
99MP0001177_atelectasis0.47026228
100MP0005381_digestive/alimentary_phenotyp0.46710684

Predicted human phenotypes

RankGene SetZ-score
1Myocardial infarction (HP:0001658)5.39111417
2Hypophosphatemic rickets (HP:0004912)5.24271133
3Facial shape deformation (HP:0011334)5.02379194
4Potter facies (HP:0002009)5.02379194
5Vascular calcification (HP:0004934)4.76931869
6Complement deficiency (HP:0004431)4.72507801
7Cardiovascular calcification (HP:0011915)4.42451930
8Neurofibrillary tangles (HP:0002185)4.40988146
9Cerebral inclusion bodies (HP:0100314)4.22504840
10Malnutrition (HP:0004395)3.93334924
11Choroideremia (HP:0001139)3.93283231
12Widely patent fontanelles and sutures (HP:0004492)3.62915535
13Neoplasm of the heart (HP:0100544)3.46584439
14Abnormality of complement system (HP:0005339)3.43062137
15Infantile muscular hypotonia (HP:0008947)3.33285229
16Agitation (HP:0000713)3.32870315
17Rickets (HP:0002748)3.32135230
18Recurrent gram-negative bacterial infections (HP:0005420)3.25871738
19Intention tremor (HP:0002080)3.22469910
20Supranuclear gaze palsy (HP:0000605)3.17332733
21Xanthomatosis (HP:0000991)3.12771406
22Abnormality of the fovea (HP:0000493)3.08970989
23Choreoathetosis (HP:0001266)3.06941586
24Gout (HP:0001997)2.91241974
25Deep venous thrombosis (HP:0002625)2.85990201
26Ketoacidosis (HP:0001993)2.76508365
27Abnormal hemoglobin (HP:0011902)2.74769219
28Hemiplegia (HP:0002301)2.71175504
29Vacuolated lymphocytes (HP:0001922)2.66967160
30Abnormal rod and cone electroretinograms (HP:0008323)2.65462796
31Pili torti (HP:0003777)2.58425257
32Testicular atrophy (HP:0000029)2.56748360
33Ketosis (HP:0001946)2.56301358
34Hypopigmentation of the fundus (HP:0007894)2.55669776
35Polar cataract (HP:0010696)2.54018915
36Abnormality of purine metabolism (HP:0004352)2.50441582
37Hyperglycinuria (HP:0003108)2.44897786
38Hemorrhage of the eye (HP:0011885)2.37802797
39Osteomalacia (HP:0002749)2.37683873
40Difficulty running (HP:0009046)2.31962090
41Bony spicule pigmentary retinopathy (HP:0007737)2.29431515
42Hyperparathyroidism (HP:0000843)2.27099865
43Intrahepatic cholestasis (HP:0001406)2.26375474
44Thin bony cortex (HP:0002753)2.25432321
45Right ventricular cardiomyopathy (HP:0011663)2.23162992
46Acanthosis nigricans (HP:0000956)2.21855867
47Abnormality of aromatic amino acid family metabolism (HP:0004338)2.18851152
48Wide cranial sutures (HP:0010537)2.18706744
49Hepatoblastoma (HP:0002884)2.17211499
50Dysostosis multiplex (HP:0000943)2.15956278
51Degeneration of the lateral corticospinal tracts (HP:0002314)2.15609002
52Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.15609002
53Abnormality of glycine metabolism (HP:0010895)2.15261760
54Abnormality of serine family amino acid metabolism (HP:0010894)2.15261760
55Skin nodule (HP:0200036)2.13955870
56Focal segmental glomerulosclerosis (HP:0000097)2.13663620
57Peripheral hypomyelination (HP:0007182)2.10073274
58Hyperphosphatemia (HP:0002905)2.10066199
59Segmental peripheral demyelination/remyelination (HP:0003481)2.09647515
60Epidermoid cyst (HP:0200040)2.05911040
61Myokymia (HP:0002411)2.05481418
62Gait ataxia (HP:0002066)2.03869614
63Hyporeflexia of lower limbs (HP:0002600)2.03552344
64Restlessness (HP:0000711)1.98897380
65Systemic lupus erythematosus (HP:0002725)1.97857683
66Hypophosphatemia (HP:0002148)1.97374611
67Progressive neurologic deterioration (HP:0002344)1.94555940
68Ulnar claw (HP:0001178)1.87092624
69Hypertriglyceridemia (HP:0002155)1.86643193
70Hyperlipoproteinemia (HP:0010980)1.85714416
71Muscle fiber splitting (HP:0003555)1.84132184
72Hyperammonemia (HP:0001987)1.83904470
73Hyperglycinemia (HP:0002154)1.83029508
74Subcapsular cataract (HP:0000523)1.81933344
75Gastrointestinal dysmotility (HP:0002579)1.81599473
76Increased CSF protein (HP:0002922)1.81254257
77Glomerulosclerosis (HP:0000096)1.79537026
78Oligomenorrhea (HP:0000876)1.79417752
79Spastic diplegia (HP:0001264)1.78515269
80Abnormality of transition element cation homeostasis (HP:0011030)1.77228662
81Ectopia lentis (HP:0001083)1.76815763
82Abnormal hair laboratory examination (HP:0003328)1.76676845
83Mucopolysacchariduria (HP:0008155)1.74974318
84Urinary glycosaminoglycan excretion (HP:0003541)1.74974318
85Abnormality of the periventricular white matter (HP:0002518)1.74579420
86Turricephaly (HP:0000262)1.74470438
87Tubulointerstitial fibrosis (HP:0005576)1.73698578
88Prominent nose (HP:0000448)1.73558207
89Abnormality of the corticospinal tract (HP:0002492)1.71653678
90Psychosis (HP:0000709)1.64743748
91Ileus (HP:0002595)1.64680077
92Abnormality of sulfur amino acid metabolism (HP:0004339)1.64551299
93Increased connective tissue (HP:0009025)1.64495789
94Abnormality of monocarboxylic acid metabolism (HP:0010996)1.63932885
95Hypoalphalipoproteinemia (HP:0003233)1.63770181
96Vertebral hypoplasia (HP:0008417)1.63692997
97Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.63692997
98Hypoglycemic coma (HP:0001325)1.61346854
99Abnormal cartilage morphology (HP:0002763)1.60093396
100Back pain (HP:0003418)1.59383992

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK23.75591791
2MST43.66996772
3ERN13.22358530
4EPHB12.79727993
5FGFR42.62845395
6SIK12.50962782
7STK392.44542678
8PKN22.38936018
9LRRK22.38519943
10PRKD32.28101642
11WNK42.25955886
12MAP3K22.18017833
13FER2.10875771
14PDGFRA2.06209743
15TRIB32.05163885
16FGFR22.00742772
17TAOK31.95921271
18EPHA21.61501683
19PAK31.31404473
20TNK21.31157009
21MYLK1.30506935
22PTK61.30266096
23TTN1.28605124
24NTRK31.28543670
25RET1.25358717
26RIPK41.19489512
27PTK2B1.18756419
28PTK21.15166775
29NTRK11.14340991
30BCKDK1.12857382
31CDK191.12455526
32MARK11.12291702
33TYRO31.11575220
34INSR1.09088737
35PRKCH1.00920628
36TESK11.00014318
37LATS10.99084501
38SCYL20.99082242
39STK100.98692806
40PDK30.98267467
41PDK40.98267467
42PAK60.95890616
43FRK0.93510721
44INSRR0.93304470
45MAP2K40.91995838
46STK380.91350388
47FGFR30.88219498
48WNK10.87282439
49EPHB20.87056024
50KSR20.84041482
51PAK20.82984955
52PAK40.82679423
53CAMK1G0.81194922
54CDK50.77422739
55MAP3K120.76059327
56EEF2K0.72237109
57LATS20.71778238
58ICK0.70148798
59DMPK0.69357737
60PRKCG0.68727951
61UHMK10.68354538
62DDR20.67803860
63MAP2K10.65133945
64STK38L0.64396414
65MAP3K70.63938477
66ALK0.63379241
67JAK20.62602270
68GSK3A0.62597867
69EPHA40.62580573
70CAMK1D0.61657707
71ROCK20.60951239
72SIK20.60140009
73MINK10.59999835
74PRKCZ0.59253641
75PRKD10.59209570
76SRC0.58886011
77PHKG10.58683528
78PHKG20.58683528
79AKT30.57770517
80CSNK1E0.56930489
81PRKACG0.55454120
82MAP3K60.55258162
83FYN0.52671798
84NTRK20.51298973
85FLT30.50132337
86MET0.49899297
87ERBB20.49179956
88FGFR10.48408467
89PDGFRB0.47609397
90PDK10.45935432
91PRKCQ0.45264030
92HIPK20.43669802
93PDPK10.41510926
94CDK60.40937628
95DAPK20.40726468
96FES0.39971015
97EGFR0.39478312
98ILK0.36450236
99CSK0.35568471
100JAK10.34416598

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009105.28970665
2Glutathione metabolism_Homo sapiens_hsa004804.39653550
3Arachidonic acid metabolism_Homo sapiens_hsa005903.63245098
4Tryptophan metabolism_Homo sapiens_hsa003803.50944839
5Thyroid hormone synthesis_Homo sapiens_hsa049183.45850265
6African trypanosomiasis_Homo sapiens_hsa051433.39225162
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.04081183
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.68485833
9Sulfur metabolism_Homo sapiens_hsa009202.28131154
10Fatty acid degradation_Homo sapiens_hsa000712.04575860
11Fatty acid metabolism_Homo sapiens_hsa012121.96454440
12Arginine biosynthesis_Homo sapiens_hsa002201.86058615
13PPAR signaling pathway_Homo sapiens_hsa033201.70158182
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.64099393
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.55491901
16Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.44955857
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.43699999
18Glycerolipid metabolism_Homo sapiens_hsa005611.37831514
19Salivary secretion_Homo sapiens_hsa049701.31087667
20Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.23834540
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.13243238
22Propanoate metabolism_Homo sapiens_hsa006401.12381149
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.10336578
24Complement and coagulation cascades_Homo sapiens_hsa046101.07221447
25Butanoate metabolism_Homo sapiens_hsa006501.03613321
26Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.03421947
27Lysosome_Homo sapiens_hsa041421.02881909
28Gastric acid secretion_Homo sapiens_hsa049711.01332238
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.00646515
30Renin secretion_Homo sapiens_hsa049240.99446092
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.98804032
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.98645950
33Bile secretion_Homo sapiens_hsa049760.93172445
34Fat digestion and absorption_Homo sapiens_hsa049750.90827987
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.90603237
36Vibrio cholerae infection_Homo sapiens_hsa051100.90232259
37beta-Alanine metabolism_Homo sapiens_hsa004100.90164592
38Collecting duct acid secretion_Homo sapiens_hsa049660.89812969
39Pyruvate metabolism_Homo sapiens_hsa006200.88727932
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88652742
41Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.88184472
42Phenylalanine metabolism_Homo sapiens_hsa003600.85657328
43GABAergic synapse_Homo sapiens_hsa047270.84021923
44Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.79958830
45Starch and sucrose metabolism_Homo sapiens_hsa005000.78593139
46Long-term potentiation_Homo sapiens_hsa047200.78297094
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74181755
48Estrogen signaling pathway_Homo sapiens_hsa049150.72304667
49Vitamin B6 metabolism_Homo sapiens_hsa007500.70617778
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.69491855
51Arginine and proline metabolism_Homo sapiens_hsa003300.66013612
52Prion diseases_Homo sapiens_hsa050200.65234375
53Circadian entrainment_Homo sapiens_hsa047130.62948256
54Histidine metabolism_Homo sapiens_hsa003400.62041637
55Aldosterone synthesis and secretion_Homo sapiens_hsa049250.61959372
56Fatty acid biosynthesis_Homo sapiens_hsa000610.61715508
57Fatty acid elongation_Homo sapiens_hsa000620.61604538
58Carbon metabolism_Homo sapiens_hsa012000.61512696
59Staphylococcus aureus infection_Homo sapiens_hsa051500.57993516
60Synaptic vesicle cycle_Homo sapiens_hsa047210.56386806
61Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55823794
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53834623
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53268329
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53234778
65Biosynthesis of amino acids_Homo sapiens_hsa012300.50610623
66Cyanoamino acid metabolism_Homo sapiens_hsa004600.49683639
67Amphetamine addiction_Homo sapiens_hsa050310.48260824
68Peroxisome_Homo sapiens_hsa041460.47829071
69Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.47565443
70Insulin secretion_Homo sapiens_hsa049110.45974538
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.43401826
72Leukocyte transendothelial migration_Homo sapiens_hsa046700.43181549
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.42813570
74Folate biosynthesis_Homo sapiens_hsa007900.42737941
75Glutamatergic synapse_Homo sapiens_hsa047240.42278714
76Tyrosine metabolism_Homo sapiens_hsa003500.41659015
77ABC transporters_Homo sapiens_hsa020100.40838293
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38580243
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38228724
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.37216947
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37059888
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36271482
83Chemical carcinogenesis_Homo sapiens_hsa052040.34441685
84Glucagon signaling pathway_Homo sapiens_hsa049220.34114882
85N-Glycan biosynthesis_Homo sapiens_hsa005100.33556240
86GnRH signaling pathway_Homo sapiens_hsa049120.32441655
87Glioma_Homo sapiens_hsa052140.29907010
88Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.29205160
89Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.29176057
90Cholinergic synapse_Homo sapiens_hsa047250.27922447
91Dopaminergic synapse_Homo sapiens_hsa047280.27264773
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.26981750
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.26630626
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.25274402
95Melanogenesis_Homo sapiens_hsa049160.23943108
96Type II diabetes mellitus_Homo sapiens_hsa049300.23130063
97Insulin resistance_Homo sapiens_hsa049310.23118689
98cAMP signaling pathway_Homo sapiens_hsa040240.22342208
99Tight junction_Homo sapiens_hsa045300.21865525
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.21222363

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